-- dump date 20140618_232816 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1217737000001 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1217737000002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1217737000003 nucleotide binding site [chemical binding]; other site 1217737000004 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1217737000005 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1217737000006 putative metal binding site [ion binding]; other site 1217737000007 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1217737000008 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1217737000009 putative metal binding site [ion binding]; other site 1217737000010 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1217737000011 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1217737000012 putative metal binding site [ion binding]; other site 1217737000013 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1217737000014 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1217737000015 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1217737000016 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1217737000017 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1217737000018 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737000019 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1217737000020 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1217737000021 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1217737000022 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1217737000023 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1217737000024 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1217737000025 active site 1217737000026 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 1217737000027 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1217737000028 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1217737000029 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737000030 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1217737000031 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737000032 EamA-like transporter family; Region: EamA; pfam00892 1217737000033 EamA-like transporter family; Region: EamA; pfam00892 1217737000034 YhhN-like protein; Region: YhhN; pfam07947 1217737000035 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1217737000036 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737000037 Catalytic site [active] 1217737000038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737000039 binding surface 1217737000040 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1217737000041 TPR motif; other site 1217737000042 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737000043 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737000044 Predicted membrane protein [Function unknown]; Region: COG2510 1217737000045 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1217737000046 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1217737000047 calcium/proton exchanger (cax); Region: cax; TIGR00378 1217737000048 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1217737000049 YfkD-like protein; Region: YfkD; pfam14167 1217737000050 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1217737000051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737000052 FeS/SAM binding site; other site 1217737000053 YfkB-like domain; Region: YfkB; pfam08756 1217737000054 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1217737000055 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1217737000056 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1217737000057 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1217737000058 NodB motif; other site 1217737000059 active site 1217737000060 catalytic site [active] 1217737000061 Cd binding site [ion binding]; other site 1217737000062 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1217737000063 endonuclease III; Region: ENDO3c; smart00478 1217737000064 minor groove reading motif; other site 1217737000065 helix-hairpin-helix signature motif; other site 1217737000066 substrate binding pocket [chemical binding]; other site 1217737000067 active site 1217737000068 TRAM domain; Region: TRAM; pfam01938 1217737000069 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1217737000070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737000071 S-adenosylmethionine binding site [chemical binding]; other site 1217737000072 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 1217737000073 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1217737000074 dimerization interface 3.5A [polypeptide binding]; other site 1217737000075 active site 1217737000076 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1217737000077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737000078 Walker A motif; other site 1217737000079 ATP binding site [chemical binding]; other site 1217737000080 Walker B motif; other site 1217737000081 arginine finger; other site 1217737000082 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1217737000083 hypothetical protein; Validated; Region: PRK06748 1217737000084 S-methylmethionine transporter; Provisional; Region: PRK11387 1217737000085 acetylornithine deacetylase; Validated; Region: PRK08596 1217737000086 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1217737000087 metal binding site [ion binding]; metal-binding site 1217737000088 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737000089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737000090 non-specific DNA binding site [nucleotide binding]; other site 1217737000091 salt bridge; other site 1217737000092 sequence-specific DNA binding site [nucleotide binding]; other site 1217737000093 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1217737000094 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1217737000095 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1217737000096 glutaminase A; Region: Gln_ase; TIGR03814 1217737000097 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1217737000098 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1217737000099 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1217737000100 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1217737000101 active site turn [active] 1217737000102 phosphorylation site [posttranslational modification] 1217737000103 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737000104 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737000105 Sm and related proteins; Region: Sm_like; cl00259 1217737000106 heptamer interface [polypeptide binding]; other site 1217737000107 Sm1 motif; other site 1217737000108 hexamer interface [polypeptide binding]; other site 1217737000109 RNA binding site [nucleotide binding]; other site 1217737000110 Sm2 motif; other site 1217737000111 Sm and related proteins; Region: Sm_like; cl00259 1217737000112 Sm1 motif; other site 1217737000113 RNA binding site [nucleotide binding]; other site 1217737000114 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1217737000115 active site 1217737000116 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737000117 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1217737000118 active site 1217737000119 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1217737000120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737000121 NAD(P) binding site [chemical binding]; other site 1217737000122 active site 1217737000123 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1217737000124 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1217737000125 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737000126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737000127 NAD(P) binding site [chemical binding]; other site 1217737000128 active site 1217737000129 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737000130 active site 1217737000131 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737000132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737000133 active site 1217737000134 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1217737000135 Pyruvate formate lyase 1; Region: PFL1; cd01678 1217737000136 coenzyme A binding site [chemical binding]; other site 1217737000137 active site 1217737000138 catalytic residues [active] 1217737000139 glycine loop; other site 1217737000140 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1217737000141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737000142 FeS/SAM binding site; other site 1217737000143 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1217737000144 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1217737000145 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1217737000146 YfhE-like protein; Region: YfhE; pfam14152 1217737000147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737000148 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1217737000149 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1217737000150 active site 1217737000151 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1217737000152 TIGR01777 family protein; Region: yfcH 1217737000153 putative NAD(P) binding site [chemical binding]; other site 1217737000154 putative active site [active] 1217737000155 recombination regulator RecX; Provisional; Region: recX; PRK14135 1217737000156 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1217737000157 YpzG-like protein; Region: YpzG; pfam14139 1217737000158 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1217737000159 WVELL protein; Region: WVELL; pfam14043 1217737000160 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1217737000161 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1217737000162 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1217737000163 minor groove reading motif; other site 1217737000164 helix-hairpin-helix signature motif; other site 1217737000165 substrate binding pocket [chemical binding]; other site 1217737000166 active site 1217737000167 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1217737000168 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1217737000169 DNA binding and oxoG recognition site [nucleotide binding] 1217737000170 YgaB-like protein; Region: YgaB; pfam14182 1217737000171 hypothetical protein; Provisional; Region: PRK13662 1217737000172 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737000173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737000174 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1217737000175 Walker A/P-loop; other site 1217737000176 ATP binding site [chemical binding]; other site 1217737000177 Q-loop/lid; other site 1217737000178 ABC transporter signature motif; other site 1217737000179 Walker B; other site 1217737000180 D-loop; other site 1217737000181 H-loop/switch region; other site 1217737000182 Predicted membrane protein [Function unknown]; Region: COG4129 1217737000183 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1217737000184 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1217737000185 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1217737000186 active site 1217737000187 dimer interface [polypeptide binding]; other site 1217737000188 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1217737000189 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1217737000190 active site 1217737000191 FMN binding site [chemical binding]; other site 1217737000192 substrate binding site [chemical binding]; other site 1217737000193 3Fe-4S cluster binding site [ion binding]; other site 1217737000194 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1217737000195 domain_subunit interface; other site 1217737000196 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1217737000197 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737000198 inhibitor-cofactor binding pocket; inhibition site 1217737000199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737000200 catalytic residue [active] 1217737000201 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1217737000202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737000203 Walker A/P-loop; other site 1217737000204 ATP binding site [chemical binding]; other site 1217737000205 Q-loop/lid; other site 1217737000206 ABC transporter signature motif; other site 1217737000207 Walker B; other site 1217737000208 D-loop; other site 1217737000209 H-loop/switch region; other site 1217737000210 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1217737000211 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1217737000212 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1217737000213 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1217737000214 Ion channel; Region: Ion_trans_2; pfam07885 1217737000215 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1217737000216 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1217737000217 catalytic triad [active] 1217737000218 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1217737000219 metal binding site 2 [ion binding]; metal-binding site 1217737000220 putative DNA binding helix; other site 1217737000221 metal binding site 1 [ion binding]; metal-binding site 1217737000222 dimer interface [polypeptide binding]; other site 1217737000223 structural Zn2+ binding site [ion binding]; other site 1217737000224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737000225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737000226 Coenzyme A binding pocket [chemical binding]; other site 1217737000227 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1217737000228 potential protein location (hypothetical protein BTF1_00410 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-H) 1217737000229 potential protein location (hypothetical protein BTF1_00410 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-T) 1217737000230 potential protein location (hypothetical protein BTF1_00410 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-W) 1217737000231 potential protein location (hypothetical protein BTF1_00410 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-Y) 1217737000232 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1217737000233 hypothetical protein; Provisional; Region: PRK12378 1217737000234 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1217737000235 nudix motif; other site 1217737000236 Transglycosylase; Region: Transgly; pfam00912 1217737000237 Thioredoxin; Region: Thioredoxin_4; pfam13462 1217737000238 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1217737000239 epoxyqueuosine reductase; Region: TIGR00276 1217737000240 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1217737000241 4Fe-4S binding domain; Region: Fer4; cl02805 1217737000242 Putative amidase domain; Region: Amidase_6; pfam12671 1217737000243 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1217737000244 PAS fold; Region: PAS_4; pfam08448 1217737000245 PAS domain; Region: PAS_9; pfam13426 1217737000246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737000247 putative active site [active] 1217737000248 heme pocket [chemical binding]; other site 1217737000249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737000250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737000251 metal binding site [ion binding]; metal-binding site 1217737000252 active site 1217737000253 I-site; other site 1217737000254 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737000255 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1217737000256 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1217737000257 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1217737000258 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737000259 heme-binding site [chemical binding]; other site 1217737000260 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000261 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1217737000262 Leucine-rich repeats; other site 1217737000263 Substrate binding site [chemical binding]; other site 1217737000264 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000265 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000266 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000267 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000268 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000269 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737000270 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1217737000271 BCCT family transporter; Region: BCCT; pfam02028 1217737000272 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1217737000273 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1217737000274 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1217737000275 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1217737000276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1217737000277 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1217737000278 Tar ligand binding domain homologue; Region: TarH; pfam02203 1217737000279 Cache domain; Region: Cache_1; pfam02743 1217737000280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737000281 dimerization interface [polypeptide binding]; other site 1217737000282 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737000283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737000284 dimer interface [polypeptide binding]; other site 1217737000285 putative CheW interface [polypeptide binding]; other site 1217737000286 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1217737000287 PAS domain; Region: PAS; smart00091 1217737000288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737000289 ATP binding site [chemical binding]; other site 1217737000290 Mg2+ binding site [ion binding]; other site 1217737000291 G-X-G motif; other site 1217737000292 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1217737000293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737000294 active site 1217737000295 phosphorylation site [posttranslational modification] 1217737000296 intermolecular recognition site; other site 1217737000297 dimerization interface [polypeptide binding]; other site 1217737000298 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1217737000299 Citrate transporter; Region: CitMHS; pfam03600 1217737000300 hypothetical protein; Provisional; Region: PRK12784 1217737000301 NosL; Region: NosL; cl01769 1217737000302 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1217737000303 Ankyrin repeat; Region: Ank; pfam00023 1217737000304 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1217737000305 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1217737000306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737000307 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1217737000308 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1217737000309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737000310 Walker A/P-loop; other site 1217737000311 ATP binding site [chemical binding]; other site 1217737000312 Q-loop/lid; other site 1217737000313 ABC transporter signature motif; other site 1217737000314 Walker B; other site 1217737000315 D-loop; other site 1217737000316 H-loop/switch region; other site 1217737000317 TOBE domain; Region: TOBE_2; pfam08402 1217737000318 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1217737000319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000320 dimer interface [polypeptide binding]; other site 1217737000321 conserved gate region; other site 1217737000322 putative PBP binding loops; other site 1217737000323 ABC-ATPase subunit interface; other site 1217737000324 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1217737000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1217737000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000327 dimer interface [polypeptide binding]; other site 1217737000328 conserved gate region; other site 1217737000329 putative PBP binding loops; other site 1217737000330 ABC-ATPase subunit interface; other site 1217737000331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1217737000332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1217737000333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737000334 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1217737000335 active site 1217737000336 metal binding site [ion binding]; metal-binding site 1217737000337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737000338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737000339 active site 1217737000340 phosphorylation site [posttranslational modification] 1217737000341 intermolecular recognition site; other site 1217737000342 dimerization interface [polypeptide binding]; other site 1217737000343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737000344 DNA binding site [nucleotide binding] 1217737000345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737000346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737000347 dimer interface [polypeptide binding]; other site 1217737000348 phosphorylation site [posttranslational modification] 1217737000349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737000350 ATP binding site [chemical binding]; other site 1217737000351 Mg2+ binding site [ion binding]; other site 1217737000352 G-X-G motif; other site 1217737000353 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1217737000354 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1217737000355 putative active site [active] 1217737000356 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1217737000357 Cache domain; Region: Cache_1; pfam02743 1217737000358 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1217737000359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737000360 dimerization interface [polypeptide binding]; other site 1217737000361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737000362 dimer interface [polypeptide binding]; other site 1217737000363 putative CheW interface [polypeptide binding]; other site 1217737000364 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1217737000365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737000366 ATP binding site [chemical binding]; other site 1217737000367 Mg2+ binding site [ion binding]; other site 1217737000368 G-X-G motif; other site 1217737000369 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1217737000370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737000371 active site 1217737000372 phosphorylation site [posttranslational modification] 1217737000373 intermolecular recognition site; other site 1217737000374 dimerization interface [polypeptide binding]; other site 1217737000375 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1217737000376 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1217737000377 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1217737000378 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1217737000379 putative NAD(P) binding site [chemical binding]; other site 1217737000380 EamA-like transporter family; Region: EamA; pfam00892 1217737000381 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737000382 EamA-like transporter family; Region: EamA; pfam00892 1217737000383 potential frameshift: common BLAST hit: gi|218895637|ref|YP_002444048.1| GntR family transcriptional regulator 1217737000384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1217737000385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737000386 Coenzyme A binding pocket [chemical binding]; other site 1217737000387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737000388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737000389 dimerization interface [polypeptide binding]; other site 1217737000390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737000391 dimer interface [polypeptide binding]; other site 1217737000392 phosphorylation site [posttranslational modification] 1217737000393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737000394 ATP binding site [chemical binding]; other site 1217737000395 Mg2+ binding site [ion binding]; other site 1217737000396 G-X-G motif; other site 1217737000397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737000398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737000399 active site 1217737000400 phosphorylation site [posttranslational modification] 1217737000401 intermolecular recognition site; other site 1217737000402 dimerization interface [polypeptide binding]; other site 1217737000403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737000404 DNA binding site [nucleotide binding] 1217737000405 Probable transposase; Region: OrfB_IS605; pfam01385 1217737000406 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1217737000407 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1217737000408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1217737000409 Arrestin_N terminal like; Region: LDB19; pfam13002 1217737000410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737000411 Coenzyme A binding pocket [chemical binding]; other site 1217737000412 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1217737000413 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1217737000414 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1217737000415 catalytic loop [active] 1217737000416 iron binding site [ion binding]; other site 1217737000417 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1217737000418 4Fe-4S binding domain; Region: Fer4; pfam00037 1217737000419 4Fe-4S binding domain; Region: Fer4; pfam00037 1217737000420 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1217737000421 [4Fe-4S] binding site [ion binding]; other site 1217737000422 molybdopterin cofactor binding site; other site 1217737000423 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1217737000424 molybdopterin cofactor binding site; other site 1217737000425 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1217737000426 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1217737000427 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1217737000428 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1217737000429 putative active site [active] 1217737000430 catalytic site [active] 1217737000431 putative metal binding site [ion binding]; other site 1217737000432 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1217737000433 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1217737000434 hexamer interface [polypeptide binding]; other site 1217737000435 ligand binding site [chemical binding]; other site 1217737000436 putative active site [active] 1217737000437 NAD(P) binding site [chemical binding]; other site 1217737000438 amino acid transporter; Region: 2A0306; TIGR00909 1217737000439 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1217737000440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737000441 dimerization interface [polypeptide binding]; other site 1217737000442 putative DNA binding site [nucleotide binding]; other site 1217737000443 putative Zn2+ binding site [ion binding]; other site 1217737000444 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1217737000445 metal-binding site [ion binding] 1217737000446 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1217737000447 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1217737000448 metal-binding site [ion binding] 1217737000449 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737000450 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1217737000451 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1217737000452 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1217737000453 active site 1217737000454 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737000455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737000456 non-specific DNA binding site [nucleotide binding]; other site 1217737000457 salt bridge; other site 1217737000458 sequence-specific DNA binding site [nucleotide binding]; other site 1217737000459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737000460 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1217737000461 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1217737000462 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1217737000463 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1217737000464 active site 1217737000465 Zn binding site [ion binding]; other site 1217737000466 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1217737000467 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737000468 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1217737000469 VanW like protein; Region: VanW; pfam04294 1217737000470 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1217737000471 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737000472 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737000473 Nucleoside recognition; Region: Gate; pfam07670 1217737000474 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737000475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737000476 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1217737000477 putative metal binding site [ion binding]; other site 1217737000478 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1217737000479 Domain of unknown function DUF21; Region: DUF21; pfam01595 1217737000480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1217737000481 Transporter associated domain; Region: CorC_HlyC; smart01091 1217737000482 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1217737000483 Aspartase; Region: Aspartase; cd01357 1217737000484 active sites [active] 1217737000485 tetramer interface [polypeptide binding]; other site 1217737000486 L-lactate permease; Region: Lactate_perm; cl00701 1217737000487 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1217737000488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737000489 dimerization interface [polypeptide binding]; other site 1217737000490 putative Zn2+ binding site [ion binding]; other site 1217737000491 putative DNA binding site [nucleotide binding]; other site 1217737000492 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 1217737000493 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1217737000494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000495 putative substrate translocation pore; other site 1217737000496 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1217737000497 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1217737000498 siderophore binding site; other site 1217737000499 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1217737000500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737000501 ABC-ATPase subunit interface; other site 1217737000502 dimer interface [polypeptide binding]; other site 1217737000503 putative PBP binding regions; other site 1217737000504 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1217737000505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737000506 ABC-ATPase subunit interface; other site 1217737000507 dimer interface [polypeptide binding]; other site 1217737000508 putative PBP binding regions; other site 1217737000509 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1217737000510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1217737000511 Walker A/P-loop; other site 1217737000512 ATP binding site [chemical binding]; other site 1217737000513 Q-loop/lid; other site 1217737000514 ABC transporter signature motif; other site 1217737000515 Walker B; other site 1217737000516 D-loop; other site 1217737000517 H-loop/switch region; other site 1217737000518 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737000519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737000520 S-adenosylmethionine binding site [chemical binding]; other site 1217737000521 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1217737000522 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1217737000523 substrate-cofactor binding pocket; other site 1217737000524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737000525 catalytic residue [active] 1217737000526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737000527 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 1217737000528 NAD binding site [chemical binding]; other site 1217737000529 homodimer interface [polypeptide binding]; other site 1217737000530 active site 1217737000531 putative substrate binding site [chemical binding]; other site 1217737000532 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1217737000533 nudix motif; other site 1217737000534 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1217737000535 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1217737000536 metal ion-dependent adhesion site (MIDAS); other site 1217737000537 MoxR-like ATPases [General function prediction only]; Region: COG0714 1217737000538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737000539 Walker A motif; other site 1217737000540 ATP binding site [chemical binding]; other site 1217737000541 Walker B motif; other site 1217737000542 arginine finger; other site 1217737000543 cardiolipin synthetase; Reviewed; Region: PRK12452 1217737000544 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1217737000545 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1217737000546 putative active site [active] 1217737000547 catalytic site [active] 1217737000548 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1217737000549 putative active site [active] 1217737000550 catalytic site [active] 1217737000551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737000552 PAS domain; Region: PAS_9; pfam13426 1217737000553 putative active site [active] 1217737000554 heme pocket [chemical binding]; other site 1217737000555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737000556 metal binding site [ion binding]; metal-binding site 1217737000557 active site 1217737000558 I-site; other site 1217737000559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737000560 Amino acid permease; Region: AA_permease_2; pfam13520 1217737000561 Spore germination protein; Region: Spore_permease; cl17796 1217737000562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737000563 DNA-binding site [nucleotide binding]; DNA binding site 1217737000564 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1217737000565 UTRA domain; Region: UTRA; pfam07702 1217737000566 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1217737000567 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1217737000568 active site turn [active] 1217737000569 phosphorylation site [posttranslational modification] 1217737000570 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1217737000571 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1217737000572 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1217737000573 Ca binding site [ion binding]; other site 1217737000574 active site 1217737000575 catalytic site [active] 1217737000576 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737000577 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737000578 Spore germination protein; Region: Spore_permease; cl17796 1217737000579 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737000580 potential frameshift: common BLAST hit: gi|222094391|ref|YP_002528450.1| protein kinase 1217737000581 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737000582 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1217737000583 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1217737000584 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1217737000585 Walker A/P-loop; other site 1217737000586 ATP binding site [chemical binding]; other site 1217737000587 Q-loop/lid; other site 1217737000588 ABC transporter signature motif; other site 1217737000589 Walker B; other site 1217737000590 D-loop; other site 1217737000591 H-loop/switch region; other site 1217737000592 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1217737000593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737000594 substrate binding pocket [chemical binding]; other site 1217737000595 membrane-bound complex binding site; other site 1217737000596 hinge residues; other site 1217737000597 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1217737000598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000599 dimer interface [polypeptide binding]; other site 1217737000600 conserved gate region; other site 1217737000601 putative PBP binding loops; other site 1217737000602 ABC-ATPase subunit interface; other site 1217737000603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000604 dimer interface [polypeptide binding]; other site 1217737000605 conserved gate region; other site 1217737000606 putative PBP binding loops; other site 1217737000607 ABC-ATPase subunit interface; other site 1217737000608 S-methylmethionine transporter; Provisional; Region: PRK11387 1217737000609 OsmC-like protein; Region: OsmC; pfam02566 1217737000610 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1217737000611 nucleotide binding site/active site [active] 1217737000612 HIT family signature motif; other site 1217737000613 catalytic residue [active] 1217737000614 RNA polymerase sigma factor; Provisional; Region: PRK12542 1217737000615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737000616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737000617 DNA binding residues [nucleotide binding] 1217737000618 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1217737000619 Predicted transcriptional regulator [Transcription]; Region: COG2378 1217737000620 HTH domain; Region: HTH_11; pfam08279 1217737000621 WYL domain; Region: WYL; pfam13280 1217737000622 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1217737000623 RibD C-terminal domain; Region: RibD_C; cl17279 1217737000624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737000625 dimerization interface [polypeptide binding]; other site 1217737000626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737000627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737000628 dimer interface [polypeptide binding]; other site 1217737000629 phosphorylation site [posttranslational modification] 1217737000630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737000631 ATP binding site [chemical binding]; other site 1217737000632 Mg2+ binding site [ion binding]; other site 1217737000633 G-X-G motif; other site 1217737000634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737000635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737000636 active site 1217737000637 phosphorylation site [posttranslational modification] 1217737000638 intermolecular recognition site; other site 1217737000639 dimerization interface [polypeptide binding]; other site 1217737000640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737000641 DNA binding site [nucleotide binding] 1217737000642 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1217737000643 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1217737000644 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1217737000645 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1217737000646 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1217737000647 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1217737000648 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1217737000649 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1217737000650 Ligand Binding Site [chemical binding]; other site 1217737000651 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 1217737000652 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1217737000653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000654 putative substrate translocation pore; other site 1217737000655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737000656 MarR family; Region: MarR; pfam01047 1217737000657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1217737000658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000659 putative substrate translocation pore; other site 1217737000660 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737000661 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737000662 DNA binding site [nucleotide binding] 1217737000663 domain linker motif; other site 1217737000664 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1217737000665 dimerization interface [polypeptide binding]; other site 1217737000666 ligand binding site [chemical binding]; other site 1217737000667 sodium binding site [ion binding]; other site 1217737000668 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1217737000669 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1217737000670 substrate binding site [chemical binding]; other site 1217737000671 dimer interface [polypeptide binding]; other site 1217737000672 ATP binding site [chemical binding]; other site 1217737000673 D-ribose pyranase; Provisional; Region: PRK11797 1217737000674 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1217737000675 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1217737000676 Walker A/P-loop; other site 1217737000677 ATP binding site [chemical binding]; other site 1217737000678 Q-loop/lid; other site 1217737000679 ABC transporter signature motif; other site 1217737000680 Walker B; other site 1217737000681 D-loop; other site 1217737000682 H-loop/switch region; other site 1217737000683 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1217737000684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1217737000685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1217737000686 TM-ABC transporter signature motif; other site 1217737000687 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1217737000688 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1217737000689 ligand binding site [chemical binding]; other site 1217737000690 dimerization interface [polypeptide binding]; other site 1217737000691 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1217737000692 active site 1217737000693 intersubunit interactions; other site 1217737000694 catalytic residue [active] 1217737000695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1217737000696 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1217737000697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000698 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737000699 putative substrate translocation pore; other site 1217737000700 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1217737000701 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1217737000702 putative NAD(P) binding site [chemical binding]; other site 1217737000703 catalytic Zn binding site [ion binding]; other site 1217737000704 Ion channel; Region: Ion_trans_2; pfam07885 1217737000705 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1217737000706 Zn binding site [ion binding]; other site 1217737000707 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1217737000708 putative catalytic site [active] 1217737000709 metal binding site A [ion binding]; metal-binding site 1217737000710 phosphate binding site [ion binding]; other site 1217737000711 metal binding site C [ion binding]; metal-binding site 1217737000712 metal binding site B [ion binding]; metal-binding site 1217737000713 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1217737000714 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1217737000715 dimer interface [polypeptide binding]; other site 1217737000716 active site 1217737000717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1217737000718 substrate binding site [chemical binding]; other site 1217737000719 catalytic residue [active] 1217737000720 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1217737000721 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737000722 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1217737000723 VanZ like family; Region: VanZ; pfam04892 1217737000724 RDD family; Region: RDD; pfam06271 1217737000725 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1217737000726 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 1217737000727 homodimer interface [polypeptide binding]; other site 1217737000728 putative GKAP docking site [polypeptide binding]; other site 1217737000729 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737000730 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737000731 dimer interface [polypeptide binding]; other site 1217737000732 putative CheW interface [polypeptide binding]; other site 1217737000733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1217737000734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1217737000735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737000736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737000737 non-specific DNA binding site [nucleotide binding]; other site 1217737000738 salt bridge; other site 1217737000739 sequence-specific DNA binding site [nucleotide binding]; other site 1217737000740 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1217737000741 active site 1217737000742 catalytic site [active] 1217737000743 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1217737000744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000745 putative substrate translocation pore; other site 1217737000746 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1217737000747 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1217737000748 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1217737000749 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1217737000750 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1217737000751 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1217737000752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737000753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737000754 non-specific DNA binding site [nucleotide binding]; other site 1217737000755 salt bridge; other site 1217737000756 sequence-specific DNA binding site [nucleotide binding]; other site 1217737000757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737000758 Coenzyme A binding pocket [chemical binding]; other site 1217737000759 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 1217737000760 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1217737000761 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1217737000762 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1217737000763 TrkA-N domain; Region: TrkA_N; pfam02254 1217737000764 TrkA-C domain; Region: TrkA_C; pfam02080 1217737000765 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1217737000766 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1217737000767 Subunit I/III interface [polypeptide binding]; other site 1217737000768 Subunit III/IV interface [polypeptide binding]; other site 1217737000769 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1217737000770 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1217737000771 D-pathway; other site 1217737000772 Putative ubiquinol binding site [chemical binding]; other site 1217737000773 Low-spin heme (heme b) binding site [chemical binding]; other site 1217737000774 Putative water exit pathway; other site 1217737000775 Binuclear center (heme o3/CuB) [ion binding]; other site 1217737000776 K-pathway; other site 1217737000777 Putative proton exit pathway; other site 1217737000778 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1217737000779 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1217737000780 S-methylmethionine transporter; Provisional; Region: PRK11387 1217737000781 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1217737000782 putative active site [active] 1217737000783 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1217737000784 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1217737000785 metal binding site [ion binding]; metal-binding site 1217737000786 dimer interface [polypeptide binding]; other site 1217737000787 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1217737000788 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1217737000789 Na binding site [ion binding]; other site 1217737000790 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737000791 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1217737000792 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737000793 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737000794 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1217737000795 Nucleoside recognition; Region: Gate; pfam07670 1217737000796 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1217737000797 Nucleoside recognition; Region: Gate; pfam07670 1217737000798 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1217737000799 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1217737000800 G1 box; other site 1217737000801 GTP/Mg2+ binding site [chemical binding]; other site 1217737000802 Switch I region; other site 1217737000803 G2 box; other site 1217737000804 G3 box; other site 1217737000805 Switch II region; other site 1217737000806 G4 box; other site 1217737000807 G5 box; other site 1217737000808 FeoA domain; Region: FeoA; pfam04023 1217737000809 PBP superfamily domain; Region: PBP_like_2; cl17296 1217737000810 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1217737000811 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1217737000812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000813 dimer interface [polypeptide binding]; other site 1217737000814 conserved gate region; other site 1217737000815 putative PBP binding loops; other site 1217737000816 ABC-ATPase subunit interface; other site 1217737000817 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1217737000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000819 dimer interface [polypeptide binding]; other site 1217737000820 conserved gate region; other site 1217737000821 putative PBP binding loops; other site 1217737000822 ABC-ATPase subunit interface; other site 1217737000823 AAA domain; Region: AAA_33; pfam13671 1217737000824 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1217737000825 active site 1217737000826 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1217737000827 Protein export membrane protein; Region: SecD_SecF; cl14618 1217737000828 FOG: CBS domain [General function prediction only]; Region: COG0517 1217737000829 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1217737000830 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 1217737000831 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 1217737000832 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737000833 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737000834 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737000835 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737000836 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737000837 Putative transcription activator [Transcription]; Region: TenA; COG0819 1217737000838 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1217737000839 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1217737000840 Walker A/P-loop; other site 1217737000841 ATP binding site [chemical binding]; other site 1217737000842 Q-loop/lid; other site 1217737000843 ABC transporter signature motif; other site 1217737000844 Walker B; other site 1217737000845 D-loop; other site 1217737000846 H-loop/switch region; other site 1217737000847 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1217737000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737000849 dimer interface [polypeptide binding]; other site 1217737000850 conserved gate region; other site 1217737000851 putative PBP binding loops; other site 1217737000852 ABC-ATPase subunit interface; other site 1217737000853 NMT1/THI5 like; Region: NMT1; pfam09084 1217737000854 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1217737000855 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1217737000856 thiamine phosphate binding site [chemical binding]; other site 1217737000857 active site 1217737000858 pyrophosphate binding site [ion binding]; other site 1217737000859 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1217737000860 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1217737000861 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1217737000862 thiS-thiF/thiG interaction site; other site 1217737000863 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1217737000864 ThiS interaction site; other site 1217737000865 putative active site [active] 1217737000866 tetramer interface [polypeptide binding]; other site 1217737000867 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1217737000868 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1217737000869 ATP binding site [chemical binding]; other site 1217737000870 substrate interface [chemical binding]; other site 1217737000871 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1217737000872 dimer interface [polypeptide binding]; other site 1217737000873 substrate binding site [chemical binding]; other site 1217737000874 ATP binding site [chemical binding]; other site 1217737000875 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1217737000876 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1217737000877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737000878 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1217737000879 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 1217737000880 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1217737000881 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1217737000882 Ligand Binding Site [chemical binding]; other site 1217737000883 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1217737000884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000885 putative substrate translocation pore; other site 1217737000886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737000887 MarR family; Region: MarR; pfam01047 1217737000888 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1217737000889 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1217737000890 active site 1217737000891 nucleophile elbow; other site 1217737000892 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1217737000893 short chain dehydrogenase; Provisional; Region: PRK06701 1217737000894 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1217737000895 NAD binding site [chemical binding]; other site 1217737000896 metal binding site [ion binding]; metal-binding site 1217737000897 active site 1217737000898 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1217737000899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1217737000900 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737000901 catalytic residues [active] 1217737000902 putative disulfide oxidoreductase; Provisional; Region: PRK03113 1217737000903 YhdB-like protein; Region: YhdB; pfam14148 1217737000904 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 1217737000905 Spore germination protein; Region: Spore_permease; cl17796 1217737000906 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737000907 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737000908 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737000909 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1217737000910 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1217737000911 putative FMN binding site [chemical binding]; other site 1217737000912 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1217737000913 SpoVR like protein; Region: SpoVR; pfam04293 1217737000914 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1217737000915 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1217737000916 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1217737000917 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1217737000918 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1217737000919 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1217737000920 putative homodimer interface [polypeptide binding]; other site 1217737000921 putative homotetramer interface [polypeptide binding]; other site 1217737000922 putative metal binding site [ion binding]; other site 1217737000923 putative homodimer-homodimer interface [polypeptide binding]; other site 1217737000924 putative allosteric switch controlling residues; other site 1217737000925 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1217737000926 CPxP motif; other site 1217737000927 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737000928 active site residue [active] 1217737000929 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 1217737000930 active site residue [active] 1217737000931 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1217737000932 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1217737000933 CPxP motif; other site 1217737000934 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737000935 active site residue [active] 1217737000936 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737000937 active site residue [active] 1217737000938 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1217737000939 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737000940 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1217737000941 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1217737000942 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1217737000943 NADP binding site [chemical binding]; other site 1217737000944 dimer interface [polypeptide binding]; other site 1217737000945 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1217737000946 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1217737000947 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1217737000948 PhoU domain; Region: PhoU; pfam01895 1217737000949 PhoU domain; Region: PhoU; pfam01895 1217737000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737000951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737000952 putative substrate translocation pore; other site 1217737000953 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1217737000954 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1217737000955 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1217737000956 HTH domain; Region: HTH_11; pfam08279 1217737000957 Mga helix-turn-helix domain; Region: Mga; pfam05043 1217737000958 PRD domain; Region: PRD; pfam00874 1217737000959 PRD domain; Region: PRD; pfam00874 1217737000960 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1217737000961 active site 1217737000962 P-loop; other site 1217737000963 phosphorylation site [posttranslational modification] 1217737000964 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1217737000965 active site 1217737000966 phosphorylation site [posttranslational modification] 1217737000967 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1217737000968 active site 1217737000969 methionine cluster; other site 1217737000970 phosphorylation site [posttranslational modification] 1217737000971 metal binding site [ion binding]; metal-binding site 1217737000972 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1217737000973 active site 1217737000974 P-loop; other site 1217737000975 phosphorylation site [posttranslational modification] 1217737000976 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1217737000977 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1217737000978 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1217737000979 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1217737000980 HEAT repeats; Region: HEAT_2; pfam13646 1217737000981 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737000982 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737000983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1217737000984 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1217737000985 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737000986 FtsX-like permease family; Region: FtsX; pfam02687 1217737000987 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737000988 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737000989 Walker A/P-loop; other site 1217737000990 ATP binding site [chemical binding]; other site 1217737000991 Q-loop/lid; other site 1217737000992 ABC transporter signature motif; other site 1217737000993 Walker B; other site 1217737000994 D-loop; other site 1217737000995 H-loop/switch region; other site 1217737000996 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1217737000997 HlyD family secretion protein; Region: HlyD_3; pfam13437 1217737000998 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 1217737000999 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1217737001000 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1217737001001 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1217737001002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737001003 dimer interface [polypeptide binding]; other site 1217737001004 conserved gate region; other site 1217737001005 ABC-ATPase subunit interface; other site 1217737001006 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1217737001007 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1217737001008 dimanganese center [ion binding]; other site 1217737001009 CotJB protein; Region: CotJB; pfam12652 1217737001010 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1217737001011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737001012 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1217737001013 active site 1217737001014 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1217737001015 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1217737001016 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1217737001017 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1217737001018 putative DNA binding site [nucleotide binding]; other site 1217737001019 putative homodimer interface [polypeptide binding]; other site 1217737001020 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1217737001021 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737001022 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737001023 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1217737001024 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1217737001025 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1217737001026 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737001027 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1217737001028 active site 1217737001029 metal binding site [ion binding]; metal-binding site 1217737001030 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1217737001031 Interdomain contacts; other site 1217737001032 Cytokine receptor motif; other site 1217737001033 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1217737001034 amino acid transporter; Region: 2A0306; TIGR00909 1217737001035 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1217737001036 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1217737001037 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1217737001038 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1217737001039 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1217737001040 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1217737001041 putative active site [active] 1217737001042 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1217737001043 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1217737001044 putative active site [active] 1217737001045 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1217737001046 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1217737001047 active site turn [active] 1217737001048 phosphorylation site [posttranslational modification] 1217737001049 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1217737001050 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1217737001051 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1217737001052 DoxX; Region: DoxX; pfam07681 1217737001053 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1217737001054 hypothetical protein; Provisional; Region: PRK06770 1217737001055 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737001056 EamA-like transporter family; Region: EamA; pfam00892 1217737001057 EamA-like transporter family; Region: EamA; pfam00892 1217737001058 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1217737001059 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1217737001060 AsnC family; Region: AsnC_trans_reg; pfam01037 1217737001061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737001062 Coenzyme A binding pocket [chemical binding]; other site 1217737001063 short chain dehydrogenase; Provisional; Region: PRK06138 1217737001064 classical (c) SDRs; Region: SDR_c; cd05233 1217737001065 NAD(P) binding site [chemical binding]; other site 1217737001066 active site 1217737001067 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1217737001068 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1217737001069 DNA binding residues [nucleotide binding] 1217737001070 putative dimer interface [polypeptide binding]; other site 1217737001071 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737001072 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737001073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737001074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737001076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001078 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737001079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737001080 dimerization interface [polypeptide binding]; other site 1217737001081 putative DNA binding site [nucleotide binding]; other site 1217737001082 putative Zn2+ binding site [ion binding]; other site 1217737001083 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1217737001084 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1217737001085 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1217737001086 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1217737001087 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1217737001088 proposed catalytic triad [active] 1217737001089 conserved cys residue [active] 1217737001090 hydroperoxidase II; Provisional; Region: katE; PRK11249 1217737001091 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1217737001092 tetramer interface [polypeptide binding]; other site 1217737001093 heme binding pocket [chemical binding]; other site 1217737001094 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1217737001095 domain interactions; other site 1217737001096 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1217737001097 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1217737001098 Spore germination protein; Region: Spore_permease; cl17796 1217737001099 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1217737001100 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1217737001101 tetrameric interface [polypeptide binding]; other site 1217737001102 activator binding site; other site 1217737001103 NADP binding site [chemical binding]; other site 1217737001104 substrate binding site [chemical binding]; other site 1217737001105 catalytic residues [active] 1217737001106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737001107 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1217737001108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737001109 Walker A/P-loop; other site 1217737001110 ATP binding site [chemical binding]; other site 1217737001111 Q-loop/lid; other site 1217737001112 ABC transporter signature motif; other site 1217737001113 Walker B; other site 1217737001114 D-loop; other site 1217737001115 H-loop/switch region; other site 1217737001116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737001117 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1217737001118 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1217737001119 Walker A/P-loop; other site 1217737001120 ATP binding site [chemical binding]; other site 1217737001121 Q-loop/lid; other site 1217737001122 ABC transporter signature motif; other site 1217737001123 Walker B; other site 1217737001124 D-loop; other site 1217737001125 H-loop/switch region; other site 1217737001126 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1217737001127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737001128 substrate binding pocket [chemical binding]; other site 1217737001129 membrane-bound complex binding site; other site 1217737001130 hinge residues; other site 1217737001131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737001132 dimer interface [polypeptide binding]; other site 1217737001133 conserved gate region; other site 1217737001134 putative PBP binding loops; other site 1217737001135 ABC-ATPase subunit interface; other site 1217737001136 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1217737001137 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1217737001138 Walker A/P-loop; other site 1217737001139 ATP binding site [chemical binding]; other site 1217737001140 Q-loop/lid; other site 1217737001141 ABC transporter signature motif; other site 1217737001142 Walker B; other site 1217737001143 D-loop; other site 1217737001144 H-loop/switch region; other site 1217737001145 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737001146 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1217737001147 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1217737001148 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1217737001149 hypothetical protein; Provisional; Region: PRK13676 1217737001150 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1217737001151 acetolactate synthase; Reviewed; Region: PRK08617 1217737001152 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1217737001153 PYR/PP interface [polypeptide binding]; other site 1217737001154 dimer interface [polypeptide binding]; other site 1217737001155 TPP binding site [chemical binding]; other site 1217737001156 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1217737001157 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1217737001158 TPP-binding site [chemical binding]; other site 1217737001159 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1217737001160 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1217737001161 active site 1217737001162 DNA binding site [nucleotide binding] 1217737001163 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1217737001164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1217737001165 active site 1217737001166 motif I; other site 1217737001167 motif II; other site 1217737001168 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1217737001169 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1217737001170 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1217737001171 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001172 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001173 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001174 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001175 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001176 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001177 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001178 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737001179 amidase catalytic site [active] 1217737001180 Zn binding residues [ion binding]; other site 1217737001181 substrate binding site [chemical binding]; other site 1217737001182 S-layer homology domain; Region: SLH; pfam00395 1217737001183 S-layer homology domain; Region: SLH; pfam00395 1217737001184 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1217737001185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737001186 FeS/SAM binding site; other site 1217737001187 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1217737001188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1217737001189 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1217737001190 acyl-activating enzyme (AAE) consensus motif; other site 1217737001191 acyl-activating enzyme (AAE) consensus motif; other site 1217737001192 putative AMP binding site [chemical binding]; other site 1217737001193 putative active site [active] 1217737001194 putative CoA binding site [chemical binding]; other site 1217737001195 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1217737001196 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1217737001197 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1217737001198 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1217737001199 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1217737001200 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1217737001201 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1217737001202 S-layer homology domain; Region: SLH; pfam00395 1217737001203 S-layer homology domain; Region: SLH; pfam00395 1217737001204 S-layer homology domain; Region: SLH; pfam00395 1217737001205 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1217737001206 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1217737001207 enoyl-CoA hydratase; Provisional; Region: PRK07659 1217737001208 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1217737001209 substrate binding site [chemical binding]; other site 1217737001210 oxyanion hole (OAH) forming residues; other site 1217737001211 trimer interface [polypeptide binding]; other site 1217737001212 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 1217737001213 metal binding site [ion binding]; metal-binding site 1217737001214 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1217737001215 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1217737001216 putative oligomer interface [polypeptide binding]; other site 1217737001217 putative active site [active] 1217737001218 metal binding site [ion binding]; metal-binding site 1217737001219 S-layer homology domain; Region: SLH; pfam00395 1217737001220 S-layer homology domain; Region: SLH; pfam00395 1217737001221 S-layer homology domain; Region: SLH; pfam00395 1217737001222 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737001223 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737001224 active site 1217737001225 metal binding site [ion binding]; metal-binding site 1217737001226 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 1217737001227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737001228 S-adenosylmethionine binding site [chemical binding]; other site 1217737001229 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1217737001230 proline racemase; Provisional; Region: PRK13969 1217737001231 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1217737001232 ornithine cyclodeaminase; Validated; Region: PRK08618 1217737001233 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1217737001234 NAD(P) binding site [chemical binding]; other site 1217737001235 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1217737001236 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1217737001237 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1217737001238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737001239 dimer interface [polypeptide binding]; other site 1217737001240 conserved gate region; other site 1217737001241 putative PBP binding loops; other site 1217737001242 ABC-ATPase subunit interface; other site 1217737001243 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1217737001244 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1217737001245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737001246 dimer interface [polypeptide binding]; other site 1217737001247 conserved gate region; other site 1217737001248 putative PBP binding loops; other site 1217737001249 ABC-ATPase subunit interface; other site 1217737001250 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1217737001251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737001252 Walker A/P-loop; other site 1217737001253 ATP binding site [chemical binding]; other site 1217737001254 Q-loop/lid; other site 1217737001255 ABC transporter signature motif; other site 1217737001256 Walker B; other site 1217737001257 D-loop; other site 1217737001258 H-loop/switch region; other site 1217737001259 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1217737001260 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1217737001261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737001262 Walker A/P-loop; other site 1217737001263 ATP binding site [chemical binding]; other site 1217737001264 Q-loop/lid; other site 1217737001265 ABC transporter signature motif; other site 1217737001266 Walker B; other site 1217737001267 D-loop; other site 1217737001268 H-loop/switch region; other site 1217737001269 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1217737001270 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1217737001271 catalytic residues [active] 1217737001272 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1217737001273 SnoaL-like domain; Region: SnoaL_2; pfam12680 1217737001274 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1217737001275 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737001276 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1217737001277 acyl-activating enzyme (AAE) consensus motif; other site 1217737001278 AMP binding site [chemical binding]; other site 1217737001279 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737001280 Condensation domain; Region: Condensation; pfam00668 1217737001281 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737001282 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737001283 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737001284 acyl-activating enzyme (AAE) consensus motif; other site 1217737001285 AMP binding site [chemical binding]; other site 1217737001286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737001287 thioester reductase domain; Region: Thioester-redct; TIGR01746 1217737001288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737001289 NAD(P) binding site [chemical binding]; other site 1217737001290 active site 1217737001291 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1217737001292 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1217737001293 tetramer interface [polypeptide binding]; other site 1217737001294 active site 1217737001295 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1217737001296 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1217737001297 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1217737001298 tetramer interface [polypeptide binding]; other site 1217737001299 active site 1217737001300 Mg2+/Mn2+ binding site [ion binding]; other site 1217737001301 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1217737001302 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1217737001303 ATP binding site [chemical binding]; other site 1217737001304 substrate interface [chemical binding]; other site 1217737001305 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737001306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001307 putative substrate translocation pore; other site 1217737001308 DinB family; Region: DinB; cl17821 1217737001309 DinB superfamily; Region: DinB_2; pfam12867 1217737001310 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1217737001311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1217737001312 Helix-turn-helix domain; Region: HTH_28; pfam13518 1217737001313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1217737001314 Helix-turn-helix domain; Region: HTH_28; pfam13518 1217737001315 potential frameshift: common BLAST hit: gi|218234478|ref|YP_002369074.1| integrase core domain-containing protein 1217737001316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1217737001317 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1217737001318 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 1217737001319 LXG domain of WXG superfamily; Region: LXG; pfam04740 1217737001320 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 1217737001321 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1217737001322 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737001323 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1217737001324 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1217737001325 active site 1217737001326 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737001327 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737001328 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1217737001329 Yip1 domain; Region: Yip1; pfam04893 1217737001330 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1217737001331 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737001332 DNA binding site [nucleotide binding] 1217737001333 active site 1217737001334 Int/Topo IB signature motif; other site 1217737001335 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1217737001336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001337 putative substrate translocation pore; other site 1217737001338 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1217737001339 PAS domain; Region: PAS; smart00091 1217737001340 putative active site [active] 1217737001341 heme pocket [chemical binding]; other site 1217737001342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737001343 ATP binding site [chemical binding]; other site 1217737001344 Mg2+ binding site [ion binding]; other site 1217737001345 G-X-G motif; other site 1217737001346 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1217737001347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737001348 active site 1217737001349 phosphorylation site [posttranslational modification] 1217737001350 intermolecular recognition site; other site 1217737001351 dimerization interface [polypeptide binding]; other site 1217737001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1217737001353 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1217737001354 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1217737001355 HNH endonuclease; Region: HNH; pfam01844 1217737001356 P63C domain; Region: P63C; pfam10546 1217737001357 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1217737001358 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1217737001359 cofactor binding site; other site 1217737001360 DNA binding site [nucleotide binding] 1217737001361 substrate interaction site [chemical binding]; other site 1217737001362 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 1217737001363 HNH endonuclease; Region: HNH; pfam01844 1217737001364 AAA domain; Region: AAA_21; pfam13304 1217737001365 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1217737001366 putative active site [active] 1217737001367 putative metal-binding site [ion binding]; other site 1217737001368 Part of AAA domain; Region: AAA_19; pfam13245 1217737001369 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1217737001370 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 1217737001371 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1217737001372 replicative DNA helicase; Provisional; Region: PRK06749 1217737001373 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1217737001374 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1217737001375 Walker A motif; other site 1217737001376 ATP binding site [chemical binding]; other site 1217737001377 Walker B motif; other site 1217737001378 DNA binding loops [nucleotide binding] 1217737001379 NAD synthetase; Provisional; Region: PRK13980 1217737001380 Predicted transcriptional regulators [Transcription]; Region: COG1378 1217737001381 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1217737001382 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1217737001383 C-terminal domain interface [polypeptide binding]; other site 1217737001384 sugar binding site [chemical binding]; other site 1217737001385 hypothetical protein; Provisional; Region: PRK10621 1217737001386 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737001387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737001388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001390 putative substrate translocation pore; other site 1217737001391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001392 hypothetical protein; Provisional; Region: PRK06770 1217737001393 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1217737001394 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1217737001395 active site 1217737001396 catalytic site [active] 1217737001397 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737001398 putative DNA binding site [nucleotide binding]; other site 1217737001399 dimerization interface [polypeptide binding]; other site 1217737001400 putative Zn2+ binding site [ion binding]; other site 1217737001401 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1217737001402 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1217737001403 nucleophilic elbow; other site 1217737001404 catalytic triad; other site 1217737001405 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1217737001406 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1217737001407 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1217737001408 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1217737001409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737001410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737001411 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1217737001412 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1217737001413 putative pectinesterase; Region: PLN02432; cl01911 1217737001414 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1217737001415 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1217737001416 CGNR zinc finger; Region: zf-CGNR; pfam11706 1217737001417 HPP family; Region: HPP; pfam04982 1217737001418 YmzC-like protein; Region: YmzC; pfam14157 1217737001419 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1217737001420 nudix motif; other site 1217737001421 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1217737001422 MarR family; Region: MarR_2; pfam12802 1217737001423 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1217737001424 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1217737001425 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1217737001426 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1217737001427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737001428 putative substrate translocation pore; other site 1217737001429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737001430 putative DNA binding site [nucleotide binding]; other site 1217737001431 dimerization interface [polypeptide binding]; other site 1217737001432 putative Zn2+ binding site [ion binding]; other site 1217737001433 VanZ like family; Region: VanZ; pfam04892 1217737001434 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 1217737001435 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1217737001436 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1217737001437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001438 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1217737001439 dihydroxyacetone kinase; Provisional; Region: PRK14479 1217737001440 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1217737001441 DAK2 domain; Region: Dak2; pfam02734 1217737001442 VanZ like family; Region: VanZ; pfam04892 1217737001443 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737001444 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737001445 Walker A/P-loop; other site 1217737001446 ATP binding site [chemical binding]; other site 1217737001447 Q-loop/lid; other site 1217737001448 ABC transporter signature motif; other site 1217737001449 Walker B; other site 1217737001450 D-loop; other site 1217737001451 H-loop/switch region; other site 1217737001452 Src Homology 3 domain superfamily; Region: SH3; cl17036 1217737001453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737001454 non-specific DNA binding site [nucleotide binding]; other site 1217737001455 salt bridge; other site 1217737001456 sequence-specific DNA binding site [nucleotide binding]; other site 1217737001457 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737001458 S-layer homology domain; Region: SLH; pfam00395 1217737001459 S-layer homology domain; Region: SLH; pfam00395 1217737001460 S-layer homology domain; Region: SLH; pfam00395 1217737001461 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1217737001462 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737001463 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737001464 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1217737001465 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1217737001466 Heat induced stress protein YflT; Region: YflT; pfam11181 1217737001467 Predicted membrane protein [Function unknown]; Region: COG2261 1217737001468 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1217737001469 anti sigma factor interaction site; other site 1217737001470 regulatory phosphorylation site [posttranslational modification]; other site 1217737001471 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1217737001472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737001473 ATP binding site [chemical binding]; other site 1217737001474 Mg2+ binding site [ion binding]; other site 1217737001475 G-X-G motif; other site 1217737001476 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 1217737001477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737001478 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1217737001479 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737001480 DNA binding residues [nucleotide binding] 1217737001481 Ferritin-like domain; Region: Ferritin; pfam00210 1217737001482 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1217737001483 dinuclear metal binding motif [ion binding]; other site 1217737001484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1217737001485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737001486 active site 1217737001487 phosphorylation site [posttranslational modification] 1217737001488 intermolecular recognition site; other site 1217737001489 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1217737001490 dimerization interface [polypeptide binding]; other site 1217737001491 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1217737001492 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1217737001493 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1217737001494 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1217737001495 CHASE3 domain; Region: CHASE3; pfam05227 1217737001496 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1217737001497 GAF domain; Region: GAF; pfam01590 1217737001498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737001499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737001500 dimer interface [polypeptide binding]; other site 1217737001501 phosphorylation site [posttranslational modification] 1217737001502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737001503 ATP binding site [chemical binding]; other site 1217737001504 Mg2+ binding site [ion binding]; other site 1217737001505 G-X-G motif; other site 1217737001506 Response regulator receiver domain; Region: Response_reg; pfam00072 1217737001507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737001508 active site 1217737001509 phosphorylation site [posttranslational modification] 1217737001510 intermolecular recognition site; other site 1217737001511 dimerization interface [polypeptide binding]; other site 1217737001512 regulatory protein interface [polypeptide binding]; other site 1217737001513 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1217737001514 regulatory phosphorylation site [posttranslational modification]; other site 1217737001515 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 1217737001516 hypothetical protein; Provisional; Region: PRK12856 1217737001517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1217737001518 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1217737001519 Probable transposase; Region: OrfB_IS605; pfam01385 1217737001520 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1217737001521 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1217737001522 NADP binding site [chemical binding]; other site 1217737001523 dimer interface [polypeptide binding]; other site 1217737001524 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1217737001525 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1217737001526 active site 1217737001527 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1217737001528 YhzD-like protein; Region: YhzD; pfam14120 1217737001529 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1217737001530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737001531 active site 1217737001532 metal binding site [ion binding]; metal-binding site 1217737001533 DNA binding site [nucleotide binding] 1217737001534 AAA domain; Region: AAA_27; pfam13514 1217737001535 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1217737001536 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1217737001537 generic binding surface II; other site 1217737001538 generic binding surface I; other site 1217737001539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737001540 Zn2+ binding site [ion binding]; other site 1217737001541 Mg2+ binding site [ion binding]; other site 1217737001542 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 1217737001543 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1217737001544 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1217737001545 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737001546 Zn binding site [ion binding]; other site 1217737001547 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1217737001548 Zn binding site [ion binding]; other site 1217737001549 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1217737001550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737001551 Zn binding site [ion binding]; other site 1217737001552 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1217737001553 Zn binding site [ion binding]; other site 1217737001554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737001555 TPR motif; other site 1217737001556 binding surface 1217737001557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737001558 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1217737001559 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1217737001560 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1217737001561 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1217737001562 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1217737001563 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1217737001564 Cupin; Region: Cupin_1; smart00835 1217737001565 Cupin; Region: Cupin_1; smart00835 1217737001566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737001567 non-specific DNA binding site [nucleotide binding]; other site 1217737001568 salt bridge; other site 1217737001569 sequence-specific DNA binding site [nucleotide binding]; other site 1217737001570 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1217737001571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1217737001572 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1217737001573 Probable transposase; Region: OrfB_IS605; pfam01385 1217737001574 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1217737001575 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1217737001576 amphipathic channel; other site 1217737001577 Asn-Pro-Ala signature motifs; other site 1217737001578 glycerol kinase; Provisional; Region: glpK; PRK00047 1217737001579 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1217737001580 N- and C-terminal domain interface [polypeptide binding]; other site 1217737001581 active site 1217737001582 MgATP binding site [chemical binding]; other site 1217737001583 catalytic site [active] 1217737001584 metal binding site [ion binding]; metal-binding site 1217737001585 glycerol binding site [chemical binding]; other site 1217737001586 homotetramer interface [polypeptide binding]; other site 1217737001587 homodimer interface [polypeptide binding]; other site 1217737001588 FBP binding site [chemical binding]; other site 1217737001589 protein IIAGlc interface [polypeptide binding]; other site 1217737001590 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1217737001591 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737001592 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1217737001593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737001594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737001595 DNA binding residues [nucleotide binding] 1217737001596 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 1217737001597 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737001598 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1217737001599 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1217737001600 Part of AAA domain; Region: AAA_19; pfam13245 1217737001601 Family description; Region: UvrD_C_2; pfam13538 1217737001602 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1217737001603 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1217737001604 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1217737001605 transcriptional regulator Hpr; Provisional; Region: PRK13777 1217737001606 MarR family; Region: MarR; pfam01047 1217737001607 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1217737001608 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1217737001609 HIT family signature motif; other site 1217737001610 catalytic residue [active] 1217737001611 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737001612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737001613 Walker A/P-loop; other site 1217737001614 ATP binding site [chemical binding]; other site 1217737001615 Q-loop/lid; other site 1217737001616 ABC transporter signature motif; other site 1217737001617 Walker B; other site 1217737001618 D-loop; other site 1217737001619 H-loop/switch region; other site 1217737001620 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1217737001621 EcsC protein family; Region: EcsC; pfam12787 1217737001622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737001623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001624 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1217737001625 Predicted membrane protein [Function unknown]; Region: COG3428 1217737001626 Bacterial PH domain; Region: DUF304; pfam03703 1217737001627 Bacterial PH domain; Region: DUF304; cl01348 1217737001628 Bacterial PH domain; Region: DUF304; pfam03703 1217737001629 Protein of unknown function (DUF975); Region: DUF975; cl10504 1217737001630 Protein of unknown function (DUF975); Region: DUF975; cl10504 1217737001631 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1217737001632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001633 Collagen binding domain; Region: Collagen_bind; pfam05737 1217737001634 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737001635 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001636 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001637 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001638 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001639 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001640 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001641 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001642 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001643 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001644 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001645 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001646 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001647 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737001648 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1217737001649 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1217737001650 classical (c) SDRs; Region: SDR_c; cd05233 1217737001651 NAD(P) binding site [chemical binding]; other site 1217737001652 active site 1217737001653 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737001654 EamA-like transporter family; Region: EamA; pfam00892 1217737001655 EamA-like transporter family; Region: EamA; cl17759 1217737001656 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1217737001657 Predicted membrane protein [Function unknown]; Region: COG3428 1217737001658 Bacterial PH domain; Region: DUF304; pfam03703 1217737001659 Bacterial PH domain; Region: DUF304; pfam03703 1217737001660 Bacterial PH domain; Region: DUF304; pfam03703 1217737001661 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1217737001662 Transglycosylase; Region: Transgly; pfam00912 1217737001663 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1217737001664 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737001665 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1217737001666 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1217737001667 substrate binding site [chemical binding]; other site 1217737001668 active site 1217737001669 ferrochelatase; Provisional; Region: PRK12435 1217737001670 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1217737001671 C-terminal domain interface [polypeptide binding]; other site 1217737001672 active site 1217737001673 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1217737001674 active site 1217737001675 N-terminal domain interface [polypeptide binding]; other site 1217737001676 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1217737001677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737001678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737001679 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 1217737001680 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1217737001681 Fn3 associated; Region: Fn3_assoc; pfam13287 1217737001682 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1217737001683 generic binding surface II; other site 1217737001684 generic binding surface I; other site 1217737001685 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1217737001686 putative active site [active] 1217737001687 putative catalytic site [active] 1217737001688 putative Mg binding site IVb [ion binding]; other site 1217737001689 putative phosphate binding site [ion binding]; other site 1217737001690 putative DNA binding site [nucleotide binding]; other site 1217737001691 putative Mg binding site IVa [ion binding]; other site 1217737001692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737001693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001694 Predicted membrane protein [Function unknown]; Region: COG1511 1217737001695 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1217737001696 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1217737001697 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1217737001698 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1217737001699 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1217737001700 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1217737001701 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 1217737001702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737001703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737001704 Coenzyme A binding pocket [chemical binding]; other site 1217737001705 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737001706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737001707 DNA binding site [nucleotide binding] 1217737001708 domain linker motif; other site 1217737001709 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1217737001710 putative dimerization interface [polypeptide binding]; other site 1217737001711 putative ligand binding site [chemical binding]; other site 1217737001712 YhfH-like protein; Region: YhfH; pfam14149 1217737001713 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1217737001714 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1217737001715 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1217737001716 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1217737001717 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1217737001718 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1217737001719 acyl-activating enzyme (AAE) consensus motif; other site 1217737001720 putative AMP binding site [chemical binding]; other site 1217737001721 putative active site [active] 1217737001722 putative CoA binding site [chemical binding]; other site 1217737001723 RHS Repeat; Region: RHS_repeat; cl11982 1217737001724 RHS protein; Region: RHS; pfam03527 1217737001725 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1217737001726 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1217737001727 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1217737001728 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1217737001729 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1217737001730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737001731 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737001732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737001733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737001734 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1217737001735 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737001736 putative active site [active] 1217737001737 putative metal binding site [ion binding]; other site 1217737001738 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1217737001739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737001740 Zn2+ binding site [ion binding]; other site 1217737001741 Mg2+ binding site [ion binding]; other site 1217737001742 Putative zinc-finger; Region: zf-HC2; pfam13490 1217737001743 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1217737001744 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1217737001745 RNA polymerase sigma factor; Provisional; Region: PRK12541 1217737001746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737001747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737001748 DNA binding residues [nucleotide binding] 1217737001749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1217737001750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737001751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1217737001752 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1217737001753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737001754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737001755 dimer interface [polypeptide binding]; other site 1217737001756 phosphorylation site [posttranslational modification] 1217737001757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737001758 ATP binding site [chemical binding]; other site 1217737001759 Mg2+ binding site [ion binding]; other site 1217737001760 G-X-G motif; other site 1217737001761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737001762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737001763 active site 1217737001764 phosphorylation site [posttranslational modification] 1217737001765 intermolecular recognition site; other site 1217737001766 dimerization interface [polypeptide binding]; other site 1217737001767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737001768 DNA binding site [nucleotide binding] 1217737001769 CAAX protease self-immunity; Region: Abi; pfam02517 1217737001770 Peptidase family M48; Region: Peptidase_M48; pfam01435 1217737001771 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1217737001772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737001773 dimerization interface [polypeptide binding]; other site 1217737001774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737001775 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737001776 dimer interface [polypeptide binding]; other site 1217737001777 putative CheW interface [polypeptide binding]; other site 1217737001778 S-layer homology domain; Region: SLH; pfam00395 1217737001779 S-layer homology domain; Region: SLH; pfam00395 1217737001780 S-layer homology domain; Region: SLH; pfam00395 1217737001781 S-layer homology domain; Region: SLH; pfam00395 1217737001782 S-layer homology domain; Region: SLH; pfam00395 1217737001783 S-layer homology domain; Region: SLH; pfam00395 1217737001784 malate synthase A; Region: malate_syn_A; TIGR01344 1217737001785 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1217737001786 active site 1217737001787 isocitrate lyase; Provisional; Region: PRK15063 1217737001788 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1217737001789 tetramer interface [polypeptide binding]; other site 1217737001790 active site 1217737001791 Mg2+/Mn2+ binding site [ion binding]; other site 1217737001792 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737001793 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1217737001794 substrate binding site [chemical binding]; other site 1217737001795 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737001796 DNA-binding site [nucleotide binding]; DNA binding site 1217737001797 RNA-binding motif; other site 1217737001798 ComK protein; Region: ComK; pfam06338 1217737001799 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1217737001800 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737001801 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1217737001802 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737001803 Catalytic site [active] 1217737001804 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737001805 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1217737001806 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1217737001807 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1217737001808 Part of AAA domain; Region: AAA_19; pfam13245 1217737001809 Family description; Region: UvrD_C_2; pfam13538 1217737001810 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1217737001811 hypothetical protein; Provisional; Region: PRK07758 1217737001812 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1217737001813 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1217737001814 Spore germination protein GerPC; Region: GerPC; pfam10737 1217737001815 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1217737001816 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1217737001817 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1217737001818 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1217737001819 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1217737001820 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1217737001821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737001822 inhibitor-cofactor binding pocket; inhibition site 1217737001823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737001824 catalytic residue [active] 1217737001825 hypothetical protein; Provisional; Region: PRK13673 1217737001826 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1217737001827 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1217737001828 active site 1217737001829 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1217737001830 dimer interface [polypeptide binding]; other site 1217737001831 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1217737001832 Ligand Binding Site [chemical binding]; other site 1217737001833 Molecular Tunnel; other site 1217737001834 ferrochelatase; Provisional; Region: PRK12435 1217737001835 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1217737001836 C-terminal domain interface [polypeptide binding]; other site 1217737001837 active site 1217737001838 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1217737001839 active site 1217737001840 N-terminal domain interface [polypeptide binding]; other site 1217737001841 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1217737001842 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1217737001843 tetramer interface [polypeptide binding]; other site 1217737001844 heme binding pocket [chemical binding]; other site 1217737001845 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1217737001846 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1217737001847 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1217737001848 active site 1217737001849 catalytic site [active] 1217737001850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737001851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737001852 non-specific DNA binding site [nucleotide binding]; other site 1217737001853 salt bridge; other site 1217737001854 sequence-specific DNA binding site [nucleotide binding]; other site 1217737001855 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737001856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1217737001857 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1217737001858 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1217737001859 S1 domain; Region: S1_2; pfam13509 1217737001860 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1217737001861 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1217737001862 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1217737001863 RHS Repeat; Region: RHS_repeat; pfam05593 1217737001864 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1217737001865 RHS protein; Region: RHS; pfam03527 1217737001866 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1217737001867 RHS protein; Region: RHS; pfam03527 1217737001868 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1217737001869 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1217737001870 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1217737001871 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1217737001872 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737001873 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737001874 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737001875 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1217737001876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737001877 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737001878 active site 1217737001879 motif I; other site 1217737001880 motif II; other site 1217737001881 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1217737001882 YjzC-like protein; Region: YjzC; pfam14168 1217737001883 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1217737001884 Clp amino terminal domain; Region: Clp_N; pfam02861 1217737001885 Clp amino terminal domain; Region: Clp_N; pfam02861 1217737001886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737001887 Walker A motif; other site 1217737001888 ATP binding site [chemical binding]; other site 1217737001889 Walker B motif; other site 1217737001890 arginine finger; other site 1217737001891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737001892 Walker A motif; other site 1217737001893 ATP binding site [chemical binding]; other site 1217737001894 Walker B motif; other site 1217737001895 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1217737001896 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1217737001897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737001898 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737001899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737001900 ComZ; Region: ComZ; pfam10815 1217737001901 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1217737001902 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1217737001903 dimer interface [polypeptide binding]; other site 1217737001904 active site 1217737001905 CoA binding pocket [chemical binding]; other site 1217737001906 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1217737001907 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1217737001908 dimer interface [polypeptide binding]; other site 1217737001909 active site 1217737001910 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1217737001911 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1217737001912 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1217737001913 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1217737001914 active site 1217737001915 HIGH motif; other site 1217737001916 dimer interface [polypeptide binding]; other site 1217737001917 KMSKS motif; other site 1217737001918 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1217737001919 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737001920 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737001921 peptide binding site [polypeptide binding]; other site 1217737001922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1217737001923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737001924 dimer interface [polypeptide binding]; other site 1217737001925 conserved gate region; other site 1217737001926 putative PBP binding loops; other site 1217737001927 ABC-ATPase subunit interface; other site 1217737001928 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1217737001929 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1217737001930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737001931 dimer interface [polypeptide binding]; other site 1217737001932 conserved gate region; other site 1217737001933 putative PBP binding loops; other site 1217737001934 ABC-ATPase subunit interface; other site 1217737001935 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1217737001936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737001937 Walker A/P-loop; other site 1217737001938 ATP binding site [chemical binding]; other site 1217737001939 Q-loop/lid; other site 1217737001940 ABC transporter signature motif; other site 1217737001941 Walker B; other site 1217737001942 D-loop; other site 1217737001943 H-loop/switch region; other site 1217737001944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1217737001945 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1217737001946 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737001947 Walker A/P-loop; other site 1217737001948 ATP binding site [chemical binding]; other site 1217737001949 Q-loop/lid; other site 1217737001950 ABC transporter signature motif; other site 1217737001951 Walker B; other site 1217737001952 D-loop; other site 1217737001953 H-loop/switch region; other site 1217737001954 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1217737001955 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1217737001956 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1217737001957 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737001958 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737001959 peptide binding site [polypeptide binding]; other site 1217737001960 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1217737001961 ArsC family; Region: ArsC; pfam03960 1217737001962 putative catalytic residues [active] 1217737001963 thiol/disulfide switch; other site 1217737001964 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1217737001965 adaptor protein; Provisional; Region: PRK02315 1217737001966 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1217737001967 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1217737001968 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1217737001969 putative active site [active] 1217737001970 catalytic site [active] 1217737001971 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1217737001972 putative active site [active] 1217737001973 catalytic site [active] 1217737001974 Competence protein CoiA-like family; Region: CoiA; cl11541 1217737001975 oligoendopeptidase F; Region: pepF; TIGR00181 1217737001976 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1217737001977 active site 1217737001978 Zn binding site [ion binding]; other site 1217737001979 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1217737001980 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1217737001981 catalytic residues [active] 1217737001982 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1217737001983 apolar tunnel; other site 1217737001984 heme binding site [chemical binding]; other site 1217737001985 dimerization interface [polypeptide binding]; other site 1217737001986 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1217737001987 putative active site [active] 1217737001988 putative metal binding residues [ion binding]; other site 1217737001989 signature motif; other site 1217737001990 putative triphosphate binding site [ion binding]; other site 1217737001991 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1217737001992 synthetase active site [active] 1217737001993 NTP binding site [chemical binding]; other site 1217737001994 metal binding site [ion binding]; metal-binding site 1217737001995 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1217737001996 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1217737001997 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1217737001998 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1217737001999 active site 1217737002000 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1217737002001 trimer interface [polypeptide binding]; other site 1217737002002 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1217737002003 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1217737002004 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1217737002005 active site 1217737002006 metal binding site [ion binding]; metal-binding site 1217737002007 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1217737002008 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1217737002009 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1217737002010 active site 1217737002011 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737002012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737002013 S-adenosylmethionine binding site [chemical binding]; other site 1217737002014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1217737002015 potential frameshift: common BLAST hit: gi|218896247|ref|YP_002444658.1| glycosyl transferase family protein 1217737002016 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737002017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737002018 S-adenosylmethionine binding site [chemical binding]; other site 1217737002019 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1217737002020 catalytic residues [active] 1217737002021 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1217737002022 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1217737002023 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1217737002024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737002025 active site 1217737002026 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1217737002027 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1217737002028 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1217737002029 NAD binding site [chemical binding]; other site 1217737002030 substrate binding site [chemical binding]; other site 1217737002031 homodimer interface [polypeptide binding]; other site 1217737002032 active site 1217737002033 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1217737002034 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1217737002035 NADP binding site [chemical binding]; other site 1217737002036 active site 1217737002037 putative substrate binding site [chemical binding]; other site 1217737002038 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1217737002039 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1217737002040 NAD binding site [chemical binding]; other site 1217737002041 homotetramer interface [polypeptide binding]; other site 1217737002042 homodimer interface [polypeptide binding]; other site 1217737002043 substrate binding site [chemical binding]; other site 1217737002044 active site 1217737002045 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1217737002046 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1217737002047 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1217737002048 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1217737002049 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1217737002050 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1217737002051 Part of AAA domain; Region: AAA_19; pfam13245 1217737002052 Family description; Region: UvrD_C_2; pfam13538 1217737002053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737002054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737002055 Coenzyme A binding pocket [chemical binding]; other site 1217737002056 hypothetical protein; Provisional; Region: PRK13679 1217737002057 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1217737002058 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1217737002059 Putative esterase; Region: Esterase; pfam00756 1217737002060 EamA-like transporter family; Region: EamA; pfam00892 1217737002061 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737002062 EamA-like transporter family; Region: EamA; pfam00892 1217737002063 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1217737002064 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1217737002065 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1217737002066 Na binding site [ion binding]; other site 1217737002067 anthranilate synthase component I; Provisional; Region: PRK13570 1217737002068 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1217737002069 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1217737002070 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1217737002071 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1217737002072 glutamine binding [chemical binding]; other site 1217737002073 catalytic triad [active] 1217737002074 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1217737002075 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1217737002076 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1217737002077 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1217737002078 active site 1217737002079 ribulose/triose binding site [chemical binding]; other site 1217737002080 phosphate binding site [ion binding]; other site 1217737002081 substrate (anthranilate) binding pocket [chemical binding]; other site 1217737002082 product (indole) binding pocket [chemical binding]; other site 1217737002083 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1217737002084 active site 1217737002085 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1217737002086 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1217737002087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737002088 catalytic residue [active] 1217737002089 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1217737002090 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1217737002091 substrate binding site [chemical binding]; other site 1217737002092 active site 1217737002093 catalytic residues [active] 1217737002094 heterodimer interface [polypeptide binding]; other site 1217737002095 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 1217737002096 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1217737002097 L-lactate permease; Region: Lactate_perm; cl00701 1217737002098 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1217737002099 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1217737002100 Double zinc ribbon; Region: DZR; pfam12773 1217737002101 Predicted membrane protein [Function unknown]; Region: COG4640 1217737002102 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1217737002103 YARHG domain; Region: YARHG; pfam13308 1217737002104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737002105 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1217737002106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737002107 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1217737002108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737002109 Coenzyme A binding pocket [chemical binding]; other site 1217737002110 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 1217737002111 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1217737002112 NADPH bind site [chemical binding]; other site 1217737002113 putative FMN binding site [chemical binding]; other site 1217737002114 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1217737002115 putative FMN binding site [chemical binding]; other site 1217737002116 NADPH bind site [chemical binding]; other site 1217737002117 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1217737002118 YcaO-like family; Region: YcaO; pfam02624 1217737002119 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1217737002120 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1217737002121 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1217737002122 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1217737002123 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1217737002124 E3 interaction surface; other site 1217737002125 lipoyl attachment site [posttranslational modification]; other site 1217737002126 e3 binding domain; Region: E3_binding; pfam02817 1217737002127 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1217737002128 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1217737002129 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1217737002130 TPP-binding site [chemical binding]; other site 1217737002131 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1217737002132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737002133 salt bridge; other site 1217737002134 non-specific DNA binding site [nucleotide binding]; other site 1217737002135 sequence-specific DNA binding site [nucleotide binding]; other site 1217737002136 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 1217737002137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737002138 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1217737002139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737002140 Walker A/P-loop; other site 1217737002141 ATP binding site [chemical binding]; other site 1217737002142 Q-loop/lid; other site 1217737002143 ABC transporter signature motif; other site 1217737002144 Walker B; other site 1217737002145 D-loop; other site 1217737002146 H-loop/switch region; other site 1217737002147 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1217737002148 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1217737002149 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1217737002150 Homeodomain-like domain; Region: HTH_23; cl17451 1217737002151 putative transposase OrfB; Reviewed; Region: PHA02517 1217737002152 HTH-like domain; Region: HTH_21; pfam13276 1217737002153 Integrase core domain; Region: rve; pfam00665 1217737002154 Integrase core domain; Region: rve_2; pfam13333 1217737002155 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1217737002156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737002157 S-adenosylmethionine binding site [chemical binding]; other site 1217737002158 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737002159 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1217737002160 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1217737002161 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1217737002162 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737002163 Catalytic site [active] 1217737002164 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1217737002165 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 1217737002166 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 1217737002167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737002168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737002169 non-specific DNA binding site [nucleotide binding]; other site 1217737002170 salt bridge; other site 1217737002171 sequence-specific DNA binding site [nucleotide binding]; other site 1217737002172 Anti-repressor SinI; Region: SinI; pfam08671 1217737002173 Anti-repressor SinI; Region: SinI; pfam08671 1217737002174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1217737002175 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1217737002176 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1217737002177 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1217737002178 NAD(P) binding site [chemical binding]; other site 1217737002179 catalytic residues [active] 1217737002180 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1217737002181 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1217737002182 Walker A/P-loop; other site 1217737002183 ATP binding site [chemical binding]; other site 1217737002184 Q-loop/lid; other site 1217737002185 ABC transporter signature motif; other site 1217737002186 Walker B; other site 1217737002187 D-loop; other site 1217737002188 H-loop/switch region; other site 1217737002189 TOBE domain; Region: TOBE_2; pfam08402 1217737002190 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1217737002191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737002192 dimer interface [polypeptide binding]; other site 1217737002193 conserved gate region; other site 1217737002194 putative PBP binding loops; other site 1217737002195 ABC-ATPase subunit interface; other site 1217737002196 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1217737002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737002198 dimer interface [polypeptide binding]; other site 1217737002199 conserved gate region; other site 1217737002200 putative PBP binding loops; other site 1217737002201 ABC-ATPase subunit interface; other site 1217737002202 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1217737002203 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1217737002204 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1217737002205 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1217737002206 active site 1217737002207 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1217737002208 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1217737002209 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1217737002210 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1217737002211 active site 1217737002212 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1217737002213 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1217737002214 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1217737002215 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1217737002216 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1217737002217 Cysteine-rich domain; Region: CCG; pfam02754 1217737002218 Cysteine-rich domain; Region: CCG; pfam02754 1217737002219 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737002220 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1217737002221 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1217737002222 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1217737002223 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1217737002224 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1217737002225 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1217737002226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737002227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737002228 active site 1217737002229 phosphorylation site [posttranslational modification] 1217737002230 intermolecular recognition site; other site 1217737002231 dimerization interface [polypeptide binding]; other site 1217737002232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737002233 DNA binding site [nucleotide binding] 1217737002234 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1217737002235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737002236 dimerization interface [polypeptide binding]; other site 1217737002237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737002238 dimer interface [polypeptide binding]; other site 1217737002239 phosphorylation site [posttranslational modification] 1217737002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002241 ATP binding site [chemical binding]; other site 1217737002242 Mg2+ binding site [ion binding]; other site 1217737002243 G-X-G motif; other site 1217737002244 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1217737002245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737002246 DNA-binding site [nucleotide binding]; DNA binding site 1217737002247 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1217737002248 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1217737002249 Cysteine-rich domain; Region: CCG; pfam02754 1217737002250 Cysteine-rich domain; Region: CCG; pfam02754 1217737002251 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1217737002252 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1217737002253 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1217737002254 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1217737002255 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1217737002256 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1217737002257 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1217737002258 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1217737002259 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1217737002260 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1217737002261 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1217737002262 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737002263 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1217737002264 dimer interaction site [polypeptide binding]; other site 1217737002265 substrate-binding tunnel; other site 1217737002266 active site 1217737002267 catalytic site [active] 1217737002268 substrate binding site [chemical binding]; other site 1217737002269 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 1217737002270 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 1217737002271 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737002272 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 1217737002273 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 1217737002274 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1217737002275 NAD(P) binding site [chemical binding]; other site 1217737002276 homotetramer interface [polypeptide binding]; other site 1217737002277 homodimer interface [polypeptide binding]; other site 1217737002278 active site 1217737002279 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1217737002280 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1217737002281 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1217737002282 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1217737002283 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1217737002284 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1217737002285 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1217737002286 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 1217737002287 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1217737002288 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1217737002289 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1217737002290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737002291 Walker A/P-loop; other site 1217737002292 ATP binding site [chemical binding]; other site 1217737002293 Q-loop/lid; other site 1217737002294 ABC transporter signature motif; other site 1217737002295 Walker B; other site 1217737002296 D-loop; other site 1217737002297 H-loop/switch region; other site 1217737002298 TOBE domain; Region: TOBE_2; pfam08402 1217737002299 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1217737002300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737002301 dimer interface [polypeptide binding]; other site 1217737002302 conserved gate region; other site 1217737002303 putative PBP binding loops; other site 1217737002304 ABC-ATPase subunit interface; other site 1217737002305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737002306 dimer interface [polypeptide binding]; other site 1217737002307 conserved gate region; other site 1217737002308 putative PBP binding loops; other site 1217737002309 ABC-ATPase subunit interface; other site 1217737002310 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1217737002311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737002312 motif II; other site 1217737002313 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1217737002314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737002315 catalytic residue [active] 1217737002316 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1217737002317 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1217737002318 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1217737002319 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1217737002320 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737002321 heme-binding site [chemical binding]; other site 1217737002322 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1217737002323 Leucine rich repeat; Region: LRR_8; pfam13855 1217737002324 Substrate binding site [chemical binding]; other site 1217737002325 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1217737002326 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002327 Leucine-rich repeats; other site 1217737002328 Substrate binding site [chemical binding]; other site 1217737002329 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002331 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002332 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002333 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002334 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1217737002335 LRR adjacent; Region: LRR_adjacent; pfam08191 1217737002336 S-layer homology domain; Region: SLH; pfam00395 1217737002337 S-layer homology domain; Region: SLH; pfam00395 1217737002338 S-layer homology domain; Region: SLH; pfam00395 1217737002339 hypothetical protein; Validated; Region: PRK06755 1217737002340 intersubunit interface [polypeptide binding]; other site 1217737002341 active site 1217737002342 Zn2+ binding site [ion binding]; other site 1217737002343 FOG: CBS domain [General function prediction only]; Region: COG0517 1217737002344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1217737002345 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1217737002346 NodB motif; other site 1217737002347 putative active site [active] 1217737002348 putative catalytic site [active] 1217737002349 Zn binding site [ion binding]; other site 1217737002350 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1217737002351 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 1217737002352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737002353 dimer interface [polypeptide binding]; other site 1217737002354 phosphorylation site [posttranslational modification] 1217737002355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002356 ATP binding site [chemical binding]; other site 1217737002357 Mg2+ binding site [ion binding]; other site 1217737002358 G-X-G motif; other site 1217737002359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737002360 MarR family; Region: MarR; pfam01047 1217737002361 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1217737002362 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1217737002363 active site 1217737002364 Zn binding site [ion binding]; other site 1217737002365 DinB superfamily; Region: DinB_2; pfam12867 1217737002366 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1217737002367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737002368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737002369 dimer interface [polypeptide binding]; other site 1217737002370 phosphorylation site [posttranslational modification] 1217737002371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002372 ATP binding site [chemical binding]; other site 1217737002373 Mg2+ binding site [ion binding]; other site 1217737002374 G-X-G motif; other site 1217737002375 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1217737002376 Ligand Binding Site [chemical binding]; other site 1217737002377 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1217737002378 active site 1217737002379 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1217737002380 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1217737002381 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1217737002382 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 1217737002383 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1217737002384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737002385 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737002386 Coenzyme A binding pocket [chemical binding]; other site 1217737002387 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1217737002388 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1217737002389 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1217737002390 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1217737002391 active site 1217737002392 dimer interface [polypeptide binding]; other site 1217737002393 catalytic residues [active] 1217737002394 effector binding site; other site 1217737002395 R2 peptide binding site; other site 1217737002396 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1217737002397 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1217737002398 dimer interface [polypeptide binding]; other site 1217737002399 putative radical transfer pathway; other site 1217737002400 diiron center [ion binding]; other site 1217737002401 tyrosyl radical; other site 1217737002402 Predicted transcriptional regulators [Transcription]; Region: COG1725 1217737002403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737002404 DNA-binding site [nucleotide binding]; DNA binding site 1217737002405 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1217737002406 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737002407 Walker A/P-loop; other site 1217737002408 ATP binding site [chemical binding]; other site 1217737002409 Q-loop/lid; other site 1217737002410 ABC transporter signature motif; other site 1217737002411 Walker B; other site 1217737002412 D-loop; other site 1217737002413 H-loop/switch region; other site 1217737002414 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737002415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737002416 Walker A/P-loop; other site 1217737002417 ATP binding site [chemical binding]; other site 1217737002418 Q-loop/lid; other site 1217737002419 ABC transporter signature motif; other site 1217737002420 Walker B; other site 1217737002421 D-loop; other site 1217737002422 H-loop/switch region; other site 1217737002423 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1217737002424 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1217737002425 CAAX protease self-immunity; Region: Abi; pfam02517 1217737002426 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1217737002427 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 1217737002428 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1217737002429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737002430 putative DNA binding site [nucleotide binding]; other site 1217737002431 putative Zn2+ binding site [ion binding]; other site 1217737002432 AsnC family; Region: AsnC_trans_reg; pfam01037 1217737002433 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1217737002434 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737002435 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1217737002436 catalytic triad [active] 1217737002437 conserved cis-peptide bond; other site 1217737002438 SseB protein; Region: SseB; cl06279 1217737002439 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1217737002440 dimer interface [polypeptide binding]; other site 1217737002441 catalytic triad [active] 1217737002442 Nitronate monooxygenase; Region: NMO; pfam03060 1217737002443 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1217737002444 FMN binding site [chemical binding]; other site 1217737002445 substrate binding site [chemical binding]; other site 1217737002446 putative catalytic residue [active] 1217737002447 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1217737002448 DltD N-terminal region; Region: DltD_N; pfam04915 1217737002449 DltD central region; Region: DltD_M; pfam04918 1217737002450 DltD C-terminal region; Region: DltD_C; pfam04914 1217737002451 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1217737002452 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1217737002453 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1217737002454 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1217737002455 acyl-activating enzyme (AAE) consensus motif; other site 1217737002456 AMP binding site [chemical binding]; other site 1217737002457 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1217737002458 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1217737002459 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1217737002460 metal binding site [ion binding]; metal-binding site 1217737002461 dimer interface [polypeptide binding]; other site 1217737002462 flavodoxin; Provisional; Region: PRK06756 1217737002463 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1217737002464 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737002465 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737002466 active site 1217737002467 substrate binding site [chemical binding]; other site 1217737002468 ATP binding site [chemical binding]; other site 1217737002469 multidrug efflux protein; Reviewed; Region: PRK01766 1217737002470 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1217737002471 cation binding site [ion binding]; other site 1217737002472 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1217737002473 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737002474 catalytic residues [active] 1217737002475 Regulatory protein YrvL; Region: YrvL; pfam14184 1217737002476 Regulatory protein YrvL; Region: YrvL; pfam14184 1217737002477 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737002478 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1217737002479 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1217737002480 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1217737002481 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1217737002482 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1217737002483 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1217737002484 hypothetical protein; Provisional; Region: PRK03094 1217737002485 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 1217737002486 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1217737002487 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1217737002488 homodimer interface [polypeptide binding]; other site 1217737002489 substrate-cofactor binding pocket; other site 1217737002490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737002491 catalytic residue [active] 1217737002492 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1217737002493 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1217737002494 PYR/PP interface [polypeptide binding]; other site 1217737002495 dimer interface [polypeptide binding]; other site 1217737002496 TPP binding site [chemical binding]; other site 1217737002497 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1217737002498 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1217737002499 TPP-binding site [chemical binding]; other site 1217737002500 dimer interface [polypeptide binding]; other site 1217737002501 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1217737002502 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1217737002503 putative valine binding site [chemical binding]; other site 1217737002504 dimer interface [polypeptide binding]; other site 1217737002505 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1217737002506 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1217737002507 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1217737002508 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1217737002509 2-isopropylmalate synthase; Validated; Region: PRK00915 1217737002510 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1217737002511 active site 1217737002512 catalytic residues [active] 1217737002513 metal binding site [ion binding]; metal-binding site 1217737002514 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1217737002515 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1217737002516 tartrate dehydrogenase; Region: TTC; TIGR02089 1217737002517 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1217737002518 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1217737002519 substrate binding site [chemical binding]; other site 1217737002520 ligand binding site [chemical binding]; other site 1217737002521 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1217737002522 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1217737002523 substrate binding site [chemical binding]; other site 1217737002524 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1217737002525 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1217737002526 dimer interface [polypeptide binding]; other site 1217737002527 motif 1; other site 1217737002528 active site 1217737002529 motif 2; other site 1217737002530 motif 3; other site 1217737002531 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1217737002532 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1217737002533 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1217737002534 histidinol dehydrogenase; Region: hisD; TIGR00069 1217737002535 NAD binding site [chemical binding]; other site 1217737002536 dimerization interface [polypeptide binding]; other site 1217737002537 product binding site; other site 1217737002538 substrate binding site [chemical binding]; other site 1217737002539 zinc binding site [ion binding]; other site 1217737002540 catalytic residues [active] 1217737002541 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1217737002542 putative active site pocket [active] 1217737002543 4-fold oligomerization interface [polypeptide binding]; other site 1217737002544 metal binding residues [ion binding]; metal-binding site 1217737002545 3-fold/trimer interface [polypeptide binding]; other site 1217737002546 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1217737002547 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1217737002548 putative active site [active] 1217737002549 oxyanion strand; other site 1217737002550 catalytic triad [active] 1217737002551 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1217737002552 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1217737002553 catalytic residues [active] 1217737002554 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1217737002555 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1217737002556 substrate binding site [chemical binding]; other site 1217737002557 glutamase interaction surface [polypeptide binding]; other site 1217737002558 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1217737002559 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1217737002560 metal binding site [ion binding]; metal-binding site 1217737002561 histidinol-phosphatase; Validated; Region: PRK06740 1217737002562 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1217737002563 dimer interface [polypeptide binding]; other site 1217737002564 active site 1217737002565 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1217737002566 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1217737002567 putative ligand binding site [chemical binding]; other site 1217737002568 putative NAD binding site [chemical binding]; other site 1217737002569 catalytic site [active] 1217737002570 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1217737002571 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1217737002572 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1217737002573 Sulfatase; Region: Sulfatase; pfam00884 1217737002574 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1217737002575 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1217737002576 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1217737002577 active site 1217737002578 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1217737002579 substrate binding site [chemical binding]; other site 1217737002580 catalytic residues [active] 1217737002581 dimer interface [polypeptide binding]; other site 1217737002582 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 1217737002583 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1217737002584 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1217737002585 Active Sites [active] 1217737002586 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1217737002587 ATP-sulfurylase; Region: ATPS; cd00517 1217737002588 active site 1217737002589 HXXH motif; other site 1217737002590 flexible loop; other site 1217737002591 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1217737002592 ligand-binding site [chemical binding]; other site 1217737002593 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1217737002594 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1217737002595 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1217737002596 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 1217737002597 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1217737002598 diphthine synthase; Region: dph5; TIGR00522 1217737002599 active site 1217737002600 SAM binding site [chemical binding]; other site 1217737002601 homodimer interface [polypeptide binding]; other site 1217737002602 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1217737002603 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1217737002604 putative active site [active] 1217737002605 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1217737002606 putative active site [active] 1217737002607 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1217737002608 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1217737002609 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1217737002610 Na2 binding site [ion binding]; other site 1217737002611 putative substrate binding site 1 [chemical binding]; other site 1217737002612 Na binding site 1 [ion binding]; other site 1217737002613 putative substrate binding site 2 [chemical binding]; other site 1217737002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1217737002615 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737002616 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737002617 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1217737002618 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1217737002619 Protein of unknown function (DUF402); Region: DUF402; cl00979 1217737002620 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1217737002621 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1217737002622 Vpu protein; Region: Vpu; pfam00558 1217737002623 PspA/IM30 family; Region: PspA_IM30; pfam04012 1217737002624 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1217737002625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1217737002626 Histidine kinase; Region: HisKA_3; pfam07730 1217737002627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002628 ATP binding site [chemical binding]; other site 1217737002629 Mg2+ binding site [ion binding]; other site 1217737002630 G-X-G motif; other site 1217737002631 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737002632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737002633 active site 1217737002634 phosphorylation site [posttranslational modification] 1217737002635 intermolecular recognition site; other site 1217737002636 dimerization interface [polypeptide binding]; other site 1217737002637 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737002638 DNA binding residues [nucleotide binding] 1217737002639 dimerization interface [polypeptide binding]; other site 1217737002640 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1217737002641 E3 interaction surface; other site 1217737002642 lipoyl attachment site [posttranslational modification]; other site 1217737002643 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1217737002644 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737002645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737002646 S-adenosylmethionine binding site [chemical binding]; other site 1217737002647 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1217737002648 Peptidase family M50; Region: Peptidase_M50; pfam02163 1217737002649 active site 1217737002650 putative substrate binding region [chemical binding]; other site 1217737002651 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1217737002652 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1217737002653 heme-binding site [chemical binding]; other site 1217737002654 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1217737002655 FAD binding pocket [chemical binding]; other site 1217737002656 FAD binding motif [chemical binding]; other site 1217737002657 phosphate binding motif [ion binding]; other site 1217737002658 beta-alpha-beta structure motif; other site 1217737002659 NAD binding pocket [chemical binding]; other site 1217737002660 Heme binding pocket [chemical binding]; other site 1217737002661 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1217737002662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1217737002663 ligand binding site [chemical binding]; other site 1217737002664 flexible hinge region; other site 1217737002665 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1217737002666 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737002667 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1217737002668 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1217737002669 Transglycosylase; Region: Transgly; pfam00912 1217737002670 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1217737002671 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737002672 Protein of unknown function (DUF3982); Region: DUF3982; pfam13138 1217737002673 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1217737002674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1217737002675 putative active site [active] 1217737002676 heme pocket [chemical binding]; other site 1217737002677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737002678 dimer interface [polypeptide binding]; other site 1217737002679 phosphorylation site [posttranslational modification] 1217737002680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002681 ATP binding site [chemical binding]; other site 1217737002682 Mg2+ binding site [ion binding]; other site 1217737002683 G-X-G motif; other site 1217737002684 Protein of unknown function DUF72; Region: DUF72; pfam01904 1217737002685 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 1217737002686 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737002687 active site 1217737002688 DNA binding site [nucleotide binding] 1217737002689 Int/Topo IB signature motif; other site 1217737002690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737002691 dimerization interface [polypeptide binding]; other site 1217737002692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737002693 dimer interface [polypeptide binding]; other site 1217737002694 phosphorylation site [posttranslational modification] 1217737002695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002696 ATP binding site [chemical binding]; other site 1217737002697 Mg2+ binding site [ion binding]; other site 1217737002698 G-X-G motif; other site 1217737002699 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1217737002700 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1217737002701 Predicted integral membrane protein [Function unknown]; Region: COG0392 1217737002702 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1217737002703 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1217737002704 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1217737002705 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1217737002706 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1217737002707 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1217737002708 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1217737002709 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737002710 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1217737002711 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1217737002712 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1217737002713 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1217737002714 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737002715 RNA binding surface [nucleotide binding]; other site 1217737002716 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1217737002717 active site 1217737002718 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1217737002719 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1217737002720 catalytic residues [active] 1217737002721 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1217737002722 ResB-like family; Region: ResB; pfam05140 1217737002723 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1217737002724 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1217737002725 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737002726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737002727 active site 1217737002728 phosphorylation site [posttranslational modification] 1217737002729 intermolecular recognition site; other site 1217737002730 dimerization interface [polypeptide binding]; other site 1217737002731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737002732 DNA binding site [nucleotide binding] 1217737002733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1217737002734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737002735 dimerization interface [polypeptide binding]; other site 1217737002736 PAS domain; Region: PAS; smart00091 1217737002737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737002738 dimer interface [polypeptide binding]; other site 1217737002739 phosphorylation site [posttranslational modification] 1217737002740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737002741 ATP binding site [chemical binding]; other site 1217737002742 Mg2+ binding site [ion binding]; other site 1217737002743 G-X-G motif; other site 1217737002744 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1217737002745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737002746 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737002747 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1217737002748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737002749 Predicted membrane protein [Function unknown]; Region: COG3601 1217737002750 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1217737002751 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1217737002752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1217737002753 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1217737002754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737002755 ATP binding site [chemical binding]; other site 1217737002756 putative Mg++ binding site [ion binding]; other site 1217737002757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737002758 nucleotide binding region [chemical binding]; other site 1217737002759 ATP-binding site [chemical binding]; other site 1217737002760 CAAX protease self-immunity; Region: Abi; pfam02517 1217737002761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737002762 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1217737002763 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737002764 putative active site [active] 1217737002765 putative metal binding site [ion binding]; other site 1217737002766 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737002767 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1217737002768 DNA binding residues [nucleotide binding] 1217737002769 B12 binding domain; Region: B12-binding_2; pfam02607 1217737002770 adaptor protein; Provisional; Region: PRK02899 1217737002771 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1217737002772 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1217737002773 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1217737002774 NAD(P) binding site [chemical binding]; other site 1217737002775 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 1217737002776 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737002777 amidase catalytic site [active] 1217737002778 Zn binding residues [ion binding]; other site 1217737002779 substrate binding site [chemical binding]; other site 1217737002780 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1217737002781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1217737002782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737002783 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1217737002784 active site 1217737002785 homotetramer interface [polypeptide binding]; other site 1217737002786 homodimer interface [polypeptide binding]; other site 1217737002787 cytidylate kinase; Provisional; Region: cmk; PRK00023 1217737002788 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1217737002789 CMP-binding site; other site 1217737002790 The sites determining sugar specificity; other site 1217737002791 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1217737002792 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1217737002793 RNA binding site [nucleotide binding]; other site 1217737002794 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1217737002795 RNA binding site [nucleotide binding]; other site 1217737002796 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1217737002797 RNA binding site [nucleotide binding]; other site 1217737002798 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1217737002799 RNA binding site [nucleotide binding]; other site 1217737002800 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1217737002801 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1217737002802 homotetramer interface [polypeptide binding]; other site 1217737002803 FMN binding site [chemical binding]; other site 1217737002804 homodimer contacts [polypeptide binding]; other site 1217737002805 putative active site [active] 1217737002806 putative substrate binding site [chemical binding]; other site 1217737002807 YpzI-like protein; Region: YpzI; pfam14140 1217737002808 YIEGIA protein; Region: YIEGIA; pfam14045 1217737002809 GTP-binding protein Der; Reviewed; Region: PRK00093 1217737002810 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1217737002811 G1 box; other site 1217737002812 GTP/Mg2+ binding site [chemical binding]; other site 1217737002813 Switch I region; other site 1217737002814 G2 box; other site 1217737002815 Switch II region; other site 1217737002816 G3 box; other site 1217737002817 G4 box; other site 1217737002818 G5 box; other site 1217737002819 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1217737002820 G1 box; other site 1217737002821 GTP/Mg2+ binding site [chemical binding]; other site 1217737002822 Switch I region; other site 1217737002823 G2 box; other site 1217737002824 G3 box; other site 1217737002825 Switch II region; other site 1217737002826 G4 box; other site 1217737002827 G5 box; other site 1217737002828 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1217737002829 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1217737002830 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1217737002831 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1217737002832 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1217737002833 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1217737002834 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1217737002835 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1217737002836 IHF dimer interface [polypeptide binding]; other site 1217737002837 IHF - DNA interface [nucleotide binding]; other site 1217737002838 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1217737002839 homodecamer interface [polypeptide binding]; other site 1217737002840 GTP cyclohydrolase I; Provisional; Region: PLN03044 1217737002841 active site 1217737002842 putative catalytic site residues [active] 1217737002843 zinc binding site [ion binding]; other site 1217737002844 GTP-CH-I/GFRP interaction surface; other site 1217737002845 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1217737002846 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1217737002847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737002848 S-adenosylmethionine binding site [chemical binding]; other site 1217737002849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1217737002850 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1217737002851 substrate binding pocket [chemical binding]; other site 1217737002852 chain length determination region; other site 1217737002853 substrate-Mg2+ binding site; other site 1217737002854 catalytic residues [active] 1217737002855 aspartate-rich region 1; other site 1217737002856 active site lid residues [active] 1217737002857 aspartate-rich region 2; other site 1217737002858 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1217737002859 active site 1217737002860 multimer interface [polypeptide binding]; other site 1217737002861 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1217737002862 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1217737002863 Tetramer interface [polypeptide binding]; other site 1217737002864 active site 1217737002865 FMN-binding site [chemical binding]; other site 1217737002866 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1217737002867 active site 1217737002868 dimer interface [polypeptide binding]; other site 1217737002869 metal binding site [ion binding]; metal-binding site 1217737002870 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1217737002871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737002872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737002873 homodimer interface [polypeptide binding]; other site 1217737002874 catalytic residue [active] 1217737002875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737002876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737002877 binding surface 1217737002878 TPR motif; other site 1217737002879 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1217737002880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737002881 binding surface 1217737002882 TPR motif; other site 1217737002883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737002884 binding surface 1217737002885 TPR motif; other site 1217737002886 hypothetical protein; Provisional; Region: PRK03636 1217737002887 UPF0302 domain; Region: UPF0302; pfam08864 1217737002888 IDEAL domain; Region: IDEAL; pfam08858 1217737002889 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1217737002890 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1217737002891 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1217737002892 iron-sulfur cluster [ion binding]; other site 1217737002893 [2Fe-2S] cluster binding site [ion binding]; other site 1217737002894 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1217737002895 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1217737002896 interchain domain interface [polypeptide binding]; other site 1217737002897 intrachain domain interface; other site 1217737002898 heme bH binding site [chemical binding]; other site 1217737002899 Qi binding site; other site 1217737002900 heme bL binding site [chemical binding]; other site 1217737002901 Qo binding site; other site 1217737002902 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1217737002903 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1217737002904 interchain domain interface [polypeptide binding]; other site 1217737002905 intrachain domain interface; other site 1217737002906 Qi binding site; other site 1217737002907 Qo binding site; other site 1217737002908 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1217737002909 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1217737002910 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 1217737002911 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1217737002912 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1217737002913 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1217737002914 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1217737002915 active site 1217737002916 Fe-S cluster binding site [ion binding]; other site 1217737002917 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737002918 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737002919 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737002920 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737002921 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1217737002922 homodimer interface [polypeptide binding]; other site 1217737002923 metal binding site [ion binding]; metal-binding site 1217737002924 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1217737002925 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1217737002926 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1217737002927 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1217737002928 active site 1217737002929 dimer interfaces [polypeptide binding]; other site 1217737002930 catalytic residues [active] 1217737002931 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1217737002932 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1217737002933 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1217737002934 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1217737002935 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1217737002936 active site 1217737002937 NTP binding site [chemical binding]; other site 1217737002938 metal binding triad [ion binding]; metal-binding site 1217737002939 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1217737002940 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1217737002941 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1217737002942 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1217737002943 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1217737002944 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1217737002945 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1217737002946 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1217737002947 oligomerization interface [polypeptide binding]; other site 1217737002948 active site 1217737002949 metal binding site [ion binding]; metal-binding site 1217737002950 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1217737002951 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1217737002952 active site 1217737002953 ATP-binding site [chemical binding]; other site 1217737002954 pantoate-binding site; other site 1217737002955 HXXH motif; other site 1217737002956 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1217737002957 tetramerization interface [polypeptide binding]; other site 1217737002958 active site 1217737002959 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1217737002960 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1217737002961 active site 1217737002962 catalytic site [active] 1217737002963 substrate binding site [chemical binding]; other site 1217737002964 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1217737002965 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1217737002966 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1217737002967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1217737002968 aspartate aminotransferase; Provisional; Region: PRK05764 1217737002969 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737002970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737002971 homodimer interface [polypeptide binding]; other site 1217737002972 catalytic residue [active] 1217737002973 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1217737002974 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1217737002975 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1217737002976 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1217737002977 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1217737002978 minor groove reading motif; other site 1217737002979 helix-hairpin-helix signature motif; other site 1217737002980 substrate binding pocket [chemical binding]; other site 1217737002981 active site 1217737002982 Transglycosylase; Region: Transgly; pfam00912 1217737002983 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1217737002984 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737002985 Fibronectin type III domain; Region: fn3; pfam00041 1217737002986 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1217737002987 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1217737002988 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1217737002989 YppF-like protein; Region: YppF; pfam14178 1217737002990 YppG-like protein; Region: YppG; pfam14179 1217737002991 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1217737002992 hypothetical protein; Provisional; Region: PRK13660 1217737002993 cell division protein GpsB; Provisional; Region: PRK14127 1217737002994 DivIVA domain; Region: DivI1A_domain; TIGR03544 1217737002995 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1217737002996 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1217737002997 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1217737002998 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 1217737002999 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1217737003000 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1217737003001 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1217737003002 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1217737003003 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1217737003004 active site 1217737003005 Zn binding site [ion binding]; other site 1217737003006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737003007 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737003008 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1217737003009 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737003010 putative active site [active] 1217737003011 putative substrate binding site [chemical binding]; other site 1217737003012 ATP binding site [chemical binding]; other site 1217737003013 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1217737003014 active site 1217737003015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737003016 active site 1217737003017 xanthine permease; Region: pbuX; TIGR03173 1217737003018 Predicted membrane protein [Function unknown]; Region: COG2311 1217737003019 Protein of unknown function (DUF418); Region: DUF418; cl12135 1217737003020 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1217737003021 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1217737003022 Dynamin family; Region: Dynamin_N; pfam00350 1217737003023 G1 box; other site 1217737003024 GTP/Mg2+ binding site [chemical binding]; other site 1217737003025 G2 box; other site 1217737003026 Switch I region; other site 1217737003027 G3 box; other site 1217737003028 Switch II region; other site 1217737003029 G4 box; other site 1217737003030 G5 box; other site 1217737003031 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1217737003032 Dynamin family; Region: Dynamin_N; pfam00350 1217737003033 G1 box; other site 1217737003034 GTP/Mg2+ binding site [chemical binding]; other site 1217737003035 G2 box; other site 1217737003036 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1217737003037 G3 box; other site 1217737003038 Switch II region; other site 1217737003039 GTP/Mg2+ binding site [chemical binding]; other site 1217737003040 G4 box; other site 1217737003041 G5 box; other site 1217737003042 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 1217737003043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003044 Coenzyme A binding pocket [chemical binding]; other site 1217737003045 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1217737003046 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1217737003047 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1217737003048 active site residue [active] 1217737003049 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1217737003050 active site residue [active] 1217737003051 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1217737003052 Predicted membrane protein [Function unknown]; Region: COG3766 1217737003053 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1217737003054 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1217737003055 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1217737003056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737003057 5'-3' exonuclease; Region: 53EXOc; smart00475 1217737003058 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1217737003059 active site 1217737003060 metal binding site 1 [ion binding]; metal-binding site 1217737003061 putative 5' ssDNA interaction site; other site 1217737003062 metal binding site 3; metal-binding site 1217737003063 metal binding site 2 [ion binding]; metal-binding site 1217737003064 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1217737003065 putative DNA binding site [nucleotide binding]; other site 1217737003066 putative metal binding site [ion binding]; other site 1217737003067 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1217737003068 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1217737003069 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1217737003070 Chain length determinant protein; Region: Wzz; cl15801 1217737003071 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1217737003072 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1217737003073 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1217737003074 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1217737003075 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1217737003076 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1217737003077 O-Antigen ligase; Region: Wzy_C; pfam04932 1217737003078 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1217737003079 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1217737003080 active site 1217737003081 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1217737003082 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1217737003083 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1217737003084 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003085 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003086 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003087 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003088 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003089 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003090 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003091 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003092 Domain of unknown function DUF11; Region: DUF11; cl17728 1217737003093 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003094 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003095 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003096 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003097 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003098 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003099 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003100 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003101 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003102 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003103 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003104 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003105 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003106 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003107 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003108 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003109 Domain of unknown function DUF11; Region: DUF11; cl17728 1217737003110 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003111 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003112 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737003113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003114 Coenzyme A binding pocket [chemical binding]; other site 1217737003115 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1217737003116 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737003117 catalytic triad [active] 1217737003118 conserved cis-peptide bond; other site 1217737003119 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737003120 EamA-like transporter family; Region: EamA; pfam00892 1217737003121 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1217737003122 RNA/DNA hybrid binding site [nucleotide binding]; other site 1217737003123 active site 1217737003124 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1217737003125 active site 1217737003126 catalytic residues [active] 1217737003127 QueT transporter; Region: QueT; pfam06177 1217737003128 hypothetical protein; Validated; Region: PRK07708 1217737003129 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1217737003130 RNA/DNA hybrid binding site [nucleotide binding]; other site 1217737003131 active site 1217737003132 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1217737003133 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1217737003134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737003135 DNA-binding site [nucleotide binding]; DNA binding site 1217737003136 RNA-binding motif; other site 1217737003137 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1217737003138 LysE type translocator; Region: LysE; pfam01810 1217737003139 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1217737003140 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1217737003141 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1217737003142 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1217737003143 Na binding site [ion binding]; other site 1217737003144 aminotransferase; Validated; Region: PRK07678 1217737003145 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737003146 inhibitor-cofactor binding pocket; inhibition site 1217737003147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003148 catalytic residue [active] 1217737003149 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1217737003150 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1217737003151 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1217737003152 potential frameshift: common BLAST hit: gi|218896644|ref|YP_002445055.1| RNA-metabolising metallo-beta-lactamase 1217737003153 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1217737003154 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1217737003155 DNA binding residues [nucleotide binding] 1217737003156 drug binding residues [chemical binding]; other site 1217737003157 dimer interface [polypeptide binding]; other site 1217737003158 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1217737003159 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1217737003160 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1217737003161 Predicted membrane protein [Function unknown]; Region: COG2323 1217737003162 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1217737003163 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1217737003164 putative active site [active] 1217737003165 Tic20-like protein; Region: Tic20; pfam09685 1217737003166 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1217737003167 dimer interface [polypeptide binding]; other site 1217737003168 FMN binding site [chemical binding]; other site 1217737003169 NADPH bind site [chemical binding]; other site 1217737003170 RNA polymerase factor sigma-70; Validated; Region: PRK06811 1217737003171 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737003172 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1217737003173 bacterial Hfq-like; Region: Hfq; cd01716 1217737003174 hexamer interface [polypeptide binding]; other site 1217737003175 Sm1 motif; other site 1217737003176 RNA binding site [nucleotide binding]; other site 1217737003177 Sm2 motif; other site 1217737003178 HD domain; Region: HD_3; pfam13023 1217737003179 flagellar motor protein MotP; Reviewed; Region: PRK06743 1217737003180 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1217737003181 flagellar motor protein MotS; Reviewed; Region: PRK06742 1217737003182 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1217737003183 ligand binding site [chemical binding]; other site 1217737003184 Response regulator receiver domain; Region: Response_reg; pfam00072 1217737003185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737003186 active site 1217737003187 phosphorylation site [posttranslational modification] 1217737003188 intermolecular recognition site; other site 1217737003189 dimerization interface [polypeptide binding]; other site 1217737003190 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1217737003191 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1217737003192 putative binding surface; other site 1217737003193 active site 1217737003194 P2 response regulator binding domain; Region: P2; pfam07194 1217737003195 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1217737003196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737003197 ATP binding site [chemical binding]; other site 1217737003198 Mg2+ binding site [ion binding]; other site 1217737003199 G-X-G motif; other site 1217737003200 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1217737003201 flagellar motor switch protein; Reviewed; Region: PRK06782 1217737003202 CheC-like family; Region: CheC; pfam04509 1217737003203 CheC-like family; Region: CheC; pfam04509 1217737003204 CheC-like family; Region: CheC; pfam04509 1217737003205 CheC-like family; Region: CheC; pfam04509 1217737003206 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1217737003207 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1217737003208 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1217737003209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737003210 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1217737003211 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 1217737003212 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 1217737003213 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1217737003214 flagellar capping protein; Validated; Region: fliD; PRK06798 1217737003215 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1217737003216 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1217737003217 Flagellar protein FliS; Region: FliS; cl00654 1217737003218 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 1217737003219 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1217737003220 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1217737003221 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1217737003222 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 1217737003223 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1217737003224 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1217737003225 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1217737003226 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1217737003227 FliG C-terminal domain; Region: FliG_C; pfam01706 1217737003228 flagellar assembly protein H; Validated; Region: fliH; PRK06800 1217737003229 Flagellar assembly protein FliH; Region: FliH; pfam02108 1217737003230 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 1217737003231 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1217737003232 Walker A motif; other site 1217737003233 ATP binding site [chemical binding]; other site 1217737003234 Walker B motif; other site 1217737003235 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1217737003236 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 1217737003237 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1217737003238 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1217737003239 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1217737003240 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1217737003241 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1217737003242 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 1217737003243 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1217737003244 Response regulator receiver domain; Region: Response_reg; pfam00072 1217737003245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737003246 active site 1217737003247 phosphorylation site [posttranslational modification] 1217737003248 intermolecular recognition site; other site 1217737003249 dimerization interface [polypeptide binding]; other site 1217737003250 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 1217737003251 potential frameshift: common BLAST hit: gi|218896692|ref|YP_002445103.1| transposase 1217737003252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1217737003253 Helix-turn-helix domain; Region: HTH_28; pfam13518 1217737003254 Helix-turn-helix domain; Region: HTH_28; pfam13518 1217737003255 flagellin; Provisional; Region: PRK12807 1217737003256 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1217737003257 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1217737003258 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1217737003259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1217737003260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1217737003261 catalytic residue [active] 1217737003262 flagellar motor switch protein; Validated; Region: PRK06789 1217737003263 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1217737003264 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1217737003265 flagellar motor switch protein; Validated; Region: PRK06788 1217737003266 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1217737003267 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1217737003268 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1217737003269 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1217737003270 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1217737003271 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1217737003272 FHIPEP family; Region: FHIPEP; pfam00771 1217737003273 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 1217737003274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1217737003275 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 1217737003276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1217737003277 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1217737003278 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1217737003279 active site 1217737003280 non-prolyl cis peptide bond; other site 1217737003281 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1217737003282 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1217737003283 Predicted transcriptional regulators [Transcription]; Region: COG1378 1217737003284 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1217737003285 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1217737003286 C-terminal domain interface [polypeptide binding]; other site 1217737003287 sugar binding site [chemical binding]; other site 1217737003288 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1217737003289 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1217737003290 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 1217737003291 Dienelactone hydrolase family; Region: DLH; pfam01738 1217737003292 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1217737003293 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1217737003294 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1217737003295 DXD motif; other site 1217737003296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737003297 PilZ domain; Region: PilZ; pfam07238 1217737003298 PilZ domain; Region: PilZ; pfam07238 1217737003299 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 1217737003300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737003301 non-specific DNA binding site [nucleotide binding]; other site 1217737003302 salt bridge; other site 1217737003303 sequence-specific DNA binding site [nucleotide binding]; other site 1217737003304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003305 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737003306 putative substrate translocation pore; other site 1217737003307 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1217737003308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737003309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737003310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737003311 dimerization interface [polypeptide binding]; other site 1217737003312 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1217737003313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737003314 Walker A/P-loop; other site 1217737003315 ATP binding site [chemical binding]; other site 1217737003316 Q-loop/lid; other site 1217737003317 ABC transporter signature motif; other site 1217737003318 Walker B; other site 1217737003319 D-loop; other site 1217737003320 H-loop/switch region; other site 1217737003321 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1217737003322 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1217737003323 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1217737003324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737003325 dimer interface [polypeptide binding]; other site 1217737003326 conserved gate region; other site 1217737003327 putative PBP binding loops; other site 1217737003328 ABC-ATPase subunit interface; other site 1217737003329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737003330 dimer interface [polypeptide binding]; other site 1217737003331 conserved gate region; other site 1217737003332 putative PBP binding loops; other site 1217737003333 ABC-ATPase subunit interface; other site 1217737003334 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1217737003335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1217737003336 Beta-Casp domain; Region: Beta-Casp; smart01027 1217737003337 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1217737003338 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1217737003339 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1217737003340 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1217737003341 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737003342 catalytic core [active] 1217737003343 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737003344 hypothetical protein; Provisional; Region: PRK09272 1217737003345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737003346 MarR family; Region: MarR_2; pfam12802 1217737003347 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1217737003348 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1217737003349 active site 1217737003350 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1217737003351 dimer interface [polypeptide binding]; other site 1217737003352 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1217737003353 Ligand Binding Site [chemical binding]; other site 1217737003354 Molecular Tunnel; other site 1217737003355 RNA polymerase factor sigma-70; Validated; Region: PRK06811 1217737003356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737003357 DNA binding residues [nucleotide binding] 1217737003358 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1217737003359 VPS10 domain; Region: VPS10; smart00602 1217737003360 VPS10 domain; Region: VPS10; smart00602 1217737003361 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1217737003362 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1217737003363 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1217737003364 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1217737003365 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1217737003366 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1217737003367 Predicted permeases [General function prediction only]; Region: COG0701 1217737003368 TIGR03943 family protein; Region: TIGR03943 1217737003369 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1217737003370 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1217737003371 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1217737003372 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1217737003373 DNA binding residues [nucleotide binding] 1217737003374 putative dimer interface [polypeptide binding]; other site 1217737003375 short chain dehydrogenase; Provisional; Region: PRK06123 1217737003376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737003377 NAD(P) binding site [chemical binding]; other site 1217737003378 active site 1217737003379 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1217737003380 Class II fumarases; Region: Fumarase_classII; cd01362 1217737003381 active site 1217737003382 tetramer interface [polypeptide binding]; other site 1217737003383 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1217737003384 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1217737003385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1217737003386 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1217737003387 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1217737003388 active site pocket [active] 1217737003389 oxyanion hole [active] 1217737003390 catalytic triad [active] 1217737003391 active site nucleophile [active] 1217737003392 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 1217737003393 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1217737003394 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1217737003395 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1217737003396 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1217737003397 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1217737003398 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1217737003399 catalytic residues [active] 1217737003400 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1217737003401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737003402 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1217737003403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737003404 non-specific DNA binding site [nucleotide binding]; other site 1217737003405 salt bridge; other site 1217737003406 sequence-specific DNA binding site [nucleotide binding]; other site 1217737003407 Cupin domain; Region: Cupin_2; pfam07883 1217737003408 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1217737003409 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1217737003410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737003411 catalytic residue [active] 1217737003412 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1217737003413 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 1217737003414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737003415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737003416 DNA binding residues [nucleotide binding] 1217737003417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737003418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737003419 active site 1217737003420 phosphorylation site [posttranslational modification] 1217737003421 intermolecular recognition site; other site 1217737003422 dimerization interface [polypeptide binding]; other site 1217737003423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737003424 DNA binding residues [nucleotide binding] 1217737003425 dimerization interface [polypeptide binding]; other site 1217737003426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1217737003427 Histidine kinase; Region: HisKA_3; pfam07730 1217737003428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737003429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737003430 Walker A/P-loop; other site 1217737003431 ATP binding site [chemical binding]; other site 1217737003432 Q-loop/lid; other site 1217737003433 ABC transporter signature motif; other site 1217737003434 Walker B; other site 1217737003435 D-loop; other site 1217737003436 H-loop/switch region; other site 1217737003437 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1217737003438 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1217737003439 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1217737003440 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1217737003441 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1217737003442 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1217737003443 PLD-like domain; Region: PLDc_2; pfam13091 1217737003444 putative active site [active] 1217737003445 catalytic site [active] 1217737003446 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1217737003447 PLD-like domain; Region: PLDc_2; pfam13091 1217737003448 putative active site [active] 1217737003449 catalytic site [active] 1217737003450 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1217737003451 putative nucleotide binding site [chemical binding]; other site 1217737003452 uridine monophosphate binding site [chemical binding]; other site 1217737003453 homohexameric interface [polypeptide binding]; other site 1217737003454 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1217737003455 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1217737003456 aspartate ammonia-lyase; Provisional; Region: PRK14515 1217737003457 Aspartase; Region: Aspartase; cd01357 1217737003458 active sites [active] 1217737003459 tetramer interface [polypeptide binding]; other site 1217737003460 malate dehydrogenase; Provisional; Region: PRK13529 1217737003461 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1217737003462 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1217737003463 NAD(P) binding site [chemical binding]; other site 1217737003464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737003465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737003466 ATP binding site [chemical binding]; other site 1217737003467 Mg2+ binding site [ion binding]; other site 1217737003468 G-X-G motif; other site 1217737003469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737003470 Response regulator receiver domain; Region: Response_reg; pfam00072 1217737003471 active site 1217737003472 phosphorylation site [posttranslational modification] 1217737003473 intermolecular recognition site; other site 1217737003474 dimerization interface [polypeptide binding]; other site 1217737003475 YcbB domain; Region: YcbB; pfam08664 1217737003476 SWIM zinc finger; Region: SWIM; pfam04434 1217737003477 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1217737003478 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1217737003479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737003480 ATP binding site [chemical binding]; other site 1217737003481 putative Mg++ binding site [ion binding]; other site 1217737003482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737003483 nucleotide binding region [chemical binding]; other site 1217737003484 ATP-binding site [chemical binding]; other site 1217737003485 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1217737003486 dimer interface [polypeptide binding]; other site 1217737003487 active site 1217737003488 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1217737003489 putative dimer interface [polypeptide binding]; other site 1217737003490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737003491 aspartate kinase; Reviewed; Region: PRK06635 1217737003492 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1217737003493 putative nucleotide binding site [chemical binding]; other site 1217737003494 putative catalytic residues [active] 1217737003495 putative Mg ion binding site [ion binding]; other site 1217737003496 putative aspartate binding site [chemical binding]; other site 1217737003497 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1217737003498 putative allosteric regulatory site; other site 1217737003499 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1217737003500 putative allosteric regulatory residue; other site 1217737003501 DoxX-like family; Region: DoxX_3; pfam13781 1217737003502 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1217737003503 YndJ-like protein; Region: YndJ; pfam14158 1217737003504 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1217737003505 putative active site [active] 1217737003506 nucleotide binding site [chemical binding]; other site 1217737003507 nudix motif; other site 1217737003508 putative metal binding site [ion binding]; other site 1217737003509 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737003510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003511 putative substrate translocation pore; other site 1217737003512 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1217737003513 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737003514 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737003515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737003517 putative substrate translocation pore; other site 1217737003518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003519 putative substrate translocation pore; other site 1217737003520 CDK-activating kinase assembly factor MAT1; Region: MAT1; pfam06391 1217737003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737003523 putative substrate translocation pore; other site 1217737003524 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1217737003525 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1217737003526 dimer interface [polypeptide binding]; other site 1217737003527 active site 1217737003528 CoA binding pocket [chemical binding]; other site 1217737003529 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1217737003530 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1217737003531 HflX GTPase family; Region: HflX; cd01878 1217737003532 G1 box; other site 1217737003533 GTP/Mg2+ binding site [chemical binding]; other site 1217737003534 Switch I region; other site 1217737003535 G2 box; other site 1217737003536 G3 box; other site 1217737003537 Switch II region; other site 1217737003538 G4 box; other site 1217737003539 G5 box; other site 1217737003540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737003542 putative substrate translocation pore; other site 1217737003543 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1217737003544 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1217737003545 dimer interface [polypeptide binding]; other site 1217737003546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003547 catalytic residue [active] 1217737003548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737003549 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1217737003550 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1217737003551 Na2 binding site [ion binding]; other site 1217737003552 putative substrate binding site 1 [chemical binding]; other site 1217737003553 Na binding site 1 [ion binding]; other site 1217737003554 putative substrate binding site 2 [chemical binding]; other site 1217737003555 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737003556 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 1217737003557 NodB motif; other site 1217737003558 putative active site [active] 1217737003559 putative catalytic site [active] 1217737003560 putative Zn binding site [ion binding]; other site 1217737003561 Mor transcription activator family; Region: Mor; cl02360 1217737003562 Predicted membrane protein [Function unknown]; Region: COG2323 1217737003563 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1217737003564 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1217737003565 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1217737003566 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1217737003567 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1217737003568 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1217737003569 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1217737003570 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1217737003571 short chain dehydrogenase; Provisional; Region: PRK12747 1217737003572 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1217737003573 NADP binding site [chemical binding]; other site 1217737003574 homodimer interface [polypeptide binding]; other site 1217737003575 active site 1217737003576 substrate binding site [chemical binding]; other site 1217737003577 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1217737003578 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1217737003579 homodimer interface [polypeptide binding]; other site 1217737003580 substrate-cofactor binding pocket; other site 1217737003581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003582 catalytic residue [active] 1217737003583 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 1217737003584 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1217737003585 PYR/PP interface [polypeptide binding]; other site 1217737003586 dimer interface [polypeptide binding]; other site 1217737003587 TPP binding site [chemical binding]; other site 1217737003588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1217737003589 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1217737003590 TPP-binding site [chemical binding]; other site 1217737003591 dimer interface [polypeptide binding]; other site 1217737003592 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1217737003593 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1217737003594 putative valine binding site [chemical binding]; other site 1217737003595 dimer interface [polypeptide binding]; other site 1217737003596 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1217737003597 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1217737003598 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1217737003599 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1217737003600 threonine dehydratase; Validated; Region: PRK08639 1217737003601 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1217737003602 tetramer interface [polypeptide binding]; other site 1217737003603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003604 catalytic residue [active] 1217737003605 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1217737003606 putative Ile/Val binding site [chemical binding]; other site 1217737003607 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1217737003608 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1217737003609 putative active site [active] 1217737003610 putative metal binding site [ion binding]; other site 1217737003611 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1217737003612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003613 Coenzyme A binding pocket [chemical binding]; other site 1217737003614 drug efflux system protein MdtG; Provisional; Region: PRK09874 1217737003615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003616 putative substrate translocation pore; other site 1217737003617 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1217737003618 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1217737003619 putative active site [active] 1217737003620 metal binding site [ion binding]; metal-binding site 1217737003621 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1217737003622 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737003623 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1217737003624 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1217737003625 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1217737003626 LytTr DNA-binding domain; Region: LytTR; pfam04397 1217737003627 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1217737003628 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1217737003629 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1217737003630 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1217737003631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003632 Coenzyme A binding pocket [chemical binding]; other site 1217737003633 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 1217737003634 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1217737003635 active site 1217737003636 putative substrate binding pocket [chemical binding]; other site 1217737003637 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737003638 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737003639 peptide binding site [polypeptide binding]; other site 1217737003640 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737003641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003642 Coenzyme A binding pocket [chemical binding]; other site 1217737003643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737003644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737003645 active site 1217737003646 phosphorylation site [posttranslational modification] 1217737003647 intermolecular recognition site; other site 1217737003648 dimerization interface [polypeptide binding]; other site 1217737003649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737003650 DNA binding site [nucleotide binding] 1217737003651 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1217737003652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737003653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737003654 dimerization interface [polypeptide binding]; other site 1217737003655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737003656 dimer interface [polypeptide binding]; other site 1217737003657 phosphorylation site [posttranslational modification] 1217737003658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737003659 ATP binding site [chemical binding]; other site 1217737003660 Mg2+ binding site [ion binding]; other site 1217737003661 G-X-G motif; other site 1217737003662 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737003663 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737003664 manganese transport protein MntH; Reviewed; Region: PRK00701 1217737003665 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1217737003666 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1217737003667 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1217737003668 active site residue [active] 1217737003669 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1217737003670 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1217737003671 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1217737003672 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1217737003673 Amino acid permease; Region: AA_permease_2; pfam13520 1217737003674 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737003675 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737003676 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737003677 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1217737003678 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1217737003679 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1217737003680 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737003681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737003682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737003683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003684 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737003685 Coenzyme A binding pocket [chemical binding]; other site 1217737003686 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1217737003687 CAAX protease self-immunity; Region: Abi; pfam02517 1217737003688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737003689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737003690 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1217737003691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737003692 DNA binding residues [nucleotide binding] 1217737003693 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1217737003694 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1217737003695 intersubunit interface [polypeptide binding]; other site 1217737003696 active site 1217737003697 catalytic residue [active] 1217737003698 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737003699 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737003700 Nucleoside recognition; Region: Gate; pfam07670 1217737003701 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737003702 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1217737003703 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1217737003704 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1217737003705 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1217737003706 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1217737003707 active site 1217737003708 catalytic motif [active] 1217737003709 Zn binding site [ion binding]; other site 1217737003710 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1217737003711 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 1217737003712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1217737003713 Helix-turn-helix domain; Region: HTH_28; pfam13518 1217737003714 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1217737003715 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1217737003716 hypothetical protein; Provisional; Region: PRK01631 1217737003717 proline aminopeptidase P II; Provisional; Region: PRK10879 1217737003718 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1217737003719 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1217737003720 active site 1217737003721 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1217737003722 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1217737003723 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1217737003724 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1217737003725 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1217737003726 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1217737003727 DNA topoisomerase III; Provisional; Region: PRK07726 1217737003728 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1217737003729 active site 1217737003730 putative interdomain interaction site [polypeptide binding]; other site 1217737003731 putative metal-binding site [ion binding]; other site 1217737003732 putative nucleotide binding site [chemical binding]; other site 1217737003733 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1217737003734 domain I; other site 1217737003735 DNA binding groove [nucleotide binding] 1217737003736 phosphate binding site [ion binding]; other site 1217737003737 domain II; other site 1217737003738 domain III; other site 1217737003739 nucleotide binding site [chemical binding]; other site 1217737003740 catalytic site [active] 1217737003741 domain IV; other site 1217737003742 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1217737003743 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1217737003744 Sodium Bile acid symporter family; Region: SBF; cl17470 1217737003745 azoreductase; Provisional; Region: PRK13555 1217737003746 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1217737003747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737003748 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1217737003749 dimer interface [polypeptide binding]; other site 1217737003750 substrate binding site [chemical binding]; other site 1217737003751 metal binding site [ion binding]; metal-binding site 1217737003752 CopC domain; Region: CopC; pfam04234 1217737003753 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1217737003754 YtkA-like; Region: YtkA; pfam13115 1217737003755 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1217737003756 EamA-like transporter family; Region: EamA; pfam00892 1217737003757 EamA-like transporter family; Region: EamA; pfam00892 1217737003758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737003759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737003760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737003761 dimerization interface [polypeptide binding]; other site 1217737003762 Predicted transcriptional regulator [Transcription]; Region: COG1959 1217737003763 Transcriptional regulator; Region: Rrf2; pfam02082 1217737003764 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1217737003765 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1217737003766 catalytic residues [active] 1217737003767 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1217737003768 dimer interface [polypeptide binding]; other site 1217737003769 FMN binding site [chemical binding]; other site 1217737003770 amidase; Provisional; Region: PRK06707 1217737003771 Amidase; Region: Amidase; cl11426 1217737003772 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1217737003773 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1217737003774 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1217737003775 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737003776 NAD binding site [chemical binding]; other site 1217737003777 dimer interface [polypeptide binding]; other site 1217737003778 substrate binding site [chemical binding]; other site 1217737003779 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1217737003780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737003781 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1217737003782 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1217737003783 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1217737003784 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1217737003785 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 1217737003786 putative ligand binding site [chemical binding]; other site 1217737003787 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1217737003788 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1217737003789 Walker A/P-loop; other site 1217737003790 ATP binding site [chemical binding]; other site 1217737003791 Q-loop/lid; other site 1217737003792 ABC transporter signature motif; other site 1217737003793 Walker B; other site 1217737003794 D-loop; other site 1217737003795 H-loop/switch region; other site 1217737003796 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1217737003797 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1217737003798 Walker A/P-loop; other site 1217737003799 ATP binding site [chemical binding]; other site 1217737003800 Q-loop/lid; other site 1217737003801 ABC transporter signature motif; other site 1217737003802 Walker B; other site 1217737003803 D-loop; other site 1217737003804 H-loop/switch region; other site 1217737003805 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1217737003806 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1217737003807 TM-ABC transporter signature motif; other site 1217737003808 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1217737003809 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1217737003810 TM-ABC transporter signature motif; other site 1217737003811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737003812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737003813 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1217737003814 dimerization interface [polypeptide binding]; other site 1217737003815 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1217737003816 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737003817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737003818 putative Zn2+ binding site [ion binding]; other site 1217737003819 putative DNA binding site [nucleotide binding]; other site 1217737003820 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1217737003821 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1217737003822 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1217737003823 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 1217737003824 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1217737003825 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1217737003826 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1217737003827 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1217737003828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737003829 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1217737003830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737003831 Walker A/P-loop; other site 1217737003832 ATP binding site [chemical binding]; other site 1217737003833 Q-loop/lid; other site 1217737003834 ABC transporter signature motif; other site 1217737003835 Walker B; other site 1217737003836 D-loop; other site 1217737003837 H-loop/switch region; other site 1217737003838 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1217737003839 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737003840 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1217737003841 Walker A/P-loop; other site 1217737003842 ATP binding site [chemical binding]; other site 1217737003843 Q-loop/lid; other site 1217737003844 ABC transporter signature motif; other site 1217737003845 Walker B; other site 1217737003846 D-loop; other site 1217737003847 H-loop/switch region; other site 1217737003848 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1217737003849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1217737003850 active site 1217737003851 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737003852 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737003853 active site 1217737003854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737003855 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737003856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1217737003857 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1217737003858 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1217737003859 inhibitor-cofactor binding pocket; inhibition site 1217737003860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003861 catalytic residue [active] 1217737003862 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1217737003863 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1217737003864 trimer interface [polypeptide binding]; other site 1217737003865 active site 1217737003866 substrate binding site [chemical binding]; other site 1217737003867 CoA binding site [chemical binding]; other site 1217737003868 EamA-like transporter family; Region: EamA; pfam00892 1217737003869 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1217737003870 putative dimer interface [polypeptide binding]; other site 1217737003871 catalytic triad [active] 1217737003872 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737003873 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1217737003874 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1217737003875 dimer interface [polypeptide binding]; other site 1217737003876 FMN binding site [chemical binding]; other site 1217737003877 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737003878 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737003879 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737003880 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1217737003881 NlpC/P60 family; Region: NLPC_P60; pfam00877 1217737003882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737003883 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737003884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737003885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737003886 Walker A/P-loop; other site 1217737003887 ATP binding site [chemical binding]; other site 1217737003888 Q-loop/lid; other site 1217737003889 ABC transporter signature motif; other site 1217737003890 Walker B; other site 1217737003891 D-loop; other site 1217737003892 H-loop/switch region; other site 1217737003893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737003894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737003895 active site 1217737003896 phosphorylation site [posttranslational modification] 1217737003897 intermolecular recognition site; other site 1217737003898 dimerization interface [polypeptide binding]; other site 1217737003899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737003900 DNA binding site [nucleotide binding] 1217737003901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737003902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737003903 dimerization interface [polypeptide binding]; other site 1217737003904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737003905 dimer interface [polypeptide binding]; other site 1217737003906 phosphorylation site [posttranslational modification] 1217737003907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737003908 ATP binding site [chemical binding]; other site 1217737003909 Mg2+ binding site [ion binding]; other site 1217737003910 G-X-G motif; other site 1217737003911 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1217737003912 classical (c) SDRs; Region: SDR_c; cd05233 1217737003913 NAD(P) binding site [chemical binding]; other site 1217737003914 active site 1217737003915 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1217737003916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737003917 S-adenosylmethionine binding site [chemical binding]; other site 1217737003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1217737003919 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1217737003920 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737003921 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1217737003922 NodB motif; other site 1217737003923 active site 1217737003924 catalytic site [active] 1217737003925 metal binding site [ion binding]; metal-binding site 1217737003926 SdpI/YhfL protein family; Region: SdpI; pfam13630 1217737003927 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1217737003928 nudix motif; other site 1217737003929 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1217737003930 homoserine dehydrogenase; Provisional; Region: PRK06349 1217737003931 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1217737003932 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1217737003933 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1217737003934 threonine synthase; Reviewed; Region: PRK06721 1217737003935 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1217737003936 homodimer interface [polypeptide binding]; other site 1217737003937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003938 catalytic residue [active] 1217737003939 homoserine kinase; Provisional; Region: PRK01212 1217737003940 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1217737003941 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1217737003942 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1217737003943 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1217737003944 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737003945 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1217737003946 NodB motif; other site 1217737003947 active site 1217737003948 catalytic site [active] 1217737003949 Zn binding site [ion binding]; other site 1217737003950 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1217737003951 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1217737003952 MgtC family; Region: MgtC; pfam02308 1217737003953 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1217737003954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737003955 Coenzyme A binding pocket [chemical binding]; other site 1217737003956 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1217737003957 IucA / IucC family; Region: IucA_IucC; pfam04183 1217737003958 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1217737003959 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1217737003960 IucA / IucC family; Region: IucA_IucC; pfam04183 1217737003961 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1217737003962 acyl-CoA synthetase; Validated; Region: PRK08308 1217737003963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1217737003964 acyl-activating enzyme (AAE) consensus motif; other site 1217737003965 AMP binding site [chemical binding]; other site 1217737003966 active site 1217737003967 CoA binding site [chemical binding]; other site 1217737003968 acyl carrier protein; Provisional; Region: PRK07639 1217737003969 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1217737003970 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1217737003971 Metal-binding active site; metal-binding site 1217737003972 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737003973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737003974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737003975 putative substrate translocation pore; other site 1217737003976 Lysine efflux permease [General function prediction only]; Region: COG1279 1217737003977 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737003978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737003979 DNA-binding site [nucleotide binding]; DNA binding site 1217737003980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737003981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737003982 homodimer interface [polypeptide binding]; other site 1217737003983 catalytic residue [active] 1217737003984 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 1217737003985 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1217737003986 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1217737003987 active site 1217737003988 nucleophile elbow; other site 1217737003989 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1217737003990 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1217737003991 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 1217737003992 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1217737003993 nudix motif; other site 1217737003994 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1217737003995 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1217737003996 homodimer interface [polypeptide binding]; other site 1217737003997 NAD binding pocket [chemical binding]; other site 1217737003998 ATP binding pocket [chemical binding]; other site 1217737003999 Mg binding site [ion binding]; other site 1217737004000 active-site loop [active] 1217737004001 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1217737004002 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1217737004003 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1217737004004 active site 1217737004005 catalytic residues [active] 1217737004006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737004007 dimerization interface [polypeptide binding]; other site 1217737004008 putative DNA binding site [nucleotide binding]; other site 1217737004009 putative Zn2+ binding site [ion binding]; other site 1217737004010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737004011 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737004012 active site 1217737004013 catalytic tetrad [active] 1217737004014 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1217737004015 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1217737004016 DinB superfamily; Region: DinB_2; pfam12867 1217737004017 GTPase RsgA; Reviewed; Region: PRK01889 1217737004018 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1217737004019 RNA binding site [nucleotide binding]; other site 1217737004020 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1217737004021 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1217737004022 GTP/Mg2+ binding site [chemical binding]; other site 1217737004023 G4 box; other site 1217737004024 G5 box; other site 1217737004025 G1 box; other site 1217737004026 Switch I region; other site 1217737004027 G2 box; other site 1217737004028 G3 box; other site 1217737004029 Switch II region; other site 1217737004030 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1217737004031 Cache domain; Region: Cache_1; pfam02743 1217737004032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737004033 dimerization interface [polypeptide binding]; other site 1217737004034 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737004035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737004036 dimer interface [polypeptide binding]; other site 1217737004037 putative CheW interface [polypeptide binding]; other site 1217737004038 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 1217737004039 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1217737004040 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1217737004041 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1217737004042 dimerization interface [polypeptide binding]; other site 1217737004043 DPS ferroxidase diiron center [ion binding]; other site 1217737004044 ion pore; other site 1217737004045 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 1217737004046 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1217737004047 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1217737004048 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1217737004049 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 1217737004050 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1217737004051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737004052 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737004053 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737004054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737004055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737004056 active site 1217737004057 catalytic tetrad [active] 1217737004058 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1217737004059 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1217737004060 P-loop, Walker A motif; other site 1217737004061 Base recognition motif; other site 1217737004062 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1217737004063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737004064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004065 Coenzyme A binding pocket [chemical binding]; other site 1217737004066 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1217737004067 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1217737004068 metal binding site [ion binding]; metal-binding site 1217737004069 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1217737004070 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1217737004071 NAD binding site [chemical binding]; other site 1217737004072 active site 1217737004073 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1217737004074 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1217737004075 active site 1217737004076 FMN binding site [chemical binding]; other site 1217737004077 substrate binding site [chemical binding]; other site 1217737004078 homotetramer interface [polypeptide binding]; other site 1217737004079 catalytic residue [active] 1217737004080 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1217737004081 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1217737004082 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1217737004083 DNA binding site [nucleotide binding] 1217737004084 active site 1217737004085 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1217737004086 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737004087 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737004088 peptide binding site [polypeptide binding]; other site 1217737004089 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1217737004090 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1217737004091 active site 1217737004092 metal binding site [ion binding]; metal-binding site 1217737004093 short chain dehydrogenase; Provisional; Region: PRK08309 1217737004094 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737004095 catalytic core [active] 1217737004096 CotH protein; Region: CotH; pfam08757 1217737004097 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1217737004098 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1217737004099 nudix motif; other site 1217737004100 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737004101 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737004102 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1217737004103 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1217737004104 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1217737004105 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1217737004106 Cl binding site [ion binding]; other site 1217737004107 oligomer interface [polypeptide binding]; other site 1217737004108 Predicted permeases [General function prediction only]; Region: COG0701 1217737004109 Predicted membrane protein [Function unknown]; Region: COG3689 1217737004110 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1217737004111 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1217737004112 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1217737004113 putative active site [active] 1217737004114 catalytic site [active] 1217737004115 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1217737004116 putative active site [active] 1217737004117 catalytic site [active] 1217737004118 Coat F domain; Region: Coat_F; pfam07875 1217737004119 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1217737004120 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1217737004121 NAD binding site [chemical binding]; other site 1217737004122 substrate binding site [chemical binding]; other site 1217737004123 putative active site [active] 1217737004124 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1217737004125 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1217737004126 Domain of unknown function DUF21; Region: DUF21; pfam01595 1217737004127 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1217737004128 Transporter associated domain; Region: CorC_HlyC; smart01091 1217737004129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737004130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737004131 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1217737004132 FOG: CBS domain [General function prediction only]; Region: COG0517 1217737004133 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1217737004134 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1217737004135 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1217737004136 dimer interface [polypeptide binding]; other site 1217737004137 putative tRNA-binding site [nucleotide binding]; other site 1217737004138 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1217737004139 DinB superfamily; Region: DinB_2; pfam12867 1217737004140 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1217737004141 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1217737004142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737004143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004144 Coenzyme A binding pocket [chemical binding]; other site 1217737004145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737004146 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1217737004147 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1217737004148 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1217737004149 nudix motif; other site 1217737004150 amidase; Provisional; Region: PRK06828 1217737004151 Amidase; Region: Amidase; pfam01425 1217737004152 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737004153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004154 putative substrate translocation pore; other site 1217737004155 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1217737004156 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1217737004157 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1217737004158 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1217737004159 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1217737004160 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737004161 catalytic core [active] 1217737004162 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737004163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737004164 active site 1217737004165 motif I; other site 1217737004166 motif II; other site 1217737004167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737004168 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737004169 MarR family; Region: MarR; pfam01047 1217737004170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004171 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1217737004172 putative substrate translocation pore; other site 1217737004173 DinB superfamily; Region: DinB_2; pfam12867 1217737004174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1217737004175 alanine racemase; Reviewed; Region: alr; PRK00053 1217737004176 active site 1217737004177 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1217737004178 dimer interface [polypeptide binding]; other site 1217737004179 substrate binding site [chemical binding]; other site 1217737004180 catalytic residues [active] 1217737004181 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737004182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737004183 S-adenosylmethionine binding site [chemical binding]; other site 1217737004184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004185 Coenzyme A binding pocket [chemical binding]; other site 1217737004186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004187 Coenzyme A binding pocket [chemical binding]; other site 1217737004188 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737004189 active site 1217737004190 ATP binding site [chemical binding]; other site 1217737004191 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737004192 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1217737004193 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1217737004194 active site 1217737004195 TDP-binding site; other site 1217737004196 acceptor substrate-binding pocket; other site 1217737004197 homodimer interface [polypeptide binding]; other site 1217737004198 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737004199 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737004200 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737004201 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737004202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737004203 DNA-binding site [nucleotide binding]; DNA binding site 1217737004204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737004205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737004206 homodimer interface [polypeptide binding]; other site 1217737004207 catalytic residue [active] 1217737004208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004209 Coenzyme A binding pocket [chemical binding]; other site 1217737004210 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737004211 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1217737004212 active site 1217737004213 metal binding site [ion binding]; metal-binding site 1217737004214 Src Homology 3 domain superfamily; Region: SH3; cl17036 1217737004215 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1217737004216 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737004217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004218 Coenzyme A binding pocket [chemical binding]; other site 1217737004219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737004220 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1217737004221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737004222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004223 Coenzyme A binding pocket [chemical binding]; other site 1217737004224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004225 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737004226 Coenzyme A binding pocket [chemical binding]; other site 1217737004227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1217737004228 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1217737004229 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1217737004230 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; pfam10661 1217737004231 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1217737004232 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1217737004233 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1217737004234 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1217737004235 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1217737004236 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737004237 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737004238 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1217737004239 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1217737004240 nucleophilic elbow; other site 1217737004241 catalytic triad; other site 1217737004242 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1217737004243 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1217737004244 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1217737004245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737004246 Coenzyme A binding pocket [chemical binding]; other site 1217737004247 Helix-turn-helix domain; Region: HTH_36; pfam13730 1217737004248 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1217737004249 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737004250 active site 1217737004251 DNA binding site [nucleotide binding] 1217737004252 Int/Topo IB signature motif; other site 1217737004253 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1217737004254 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1217737004255 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737004256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737004257 S-adenosylmethionine binding site [chemical binding]; other site 1217737004258 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1217737004259 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1217737004260 Potassium binding sites [ion binding]; other site 1217737004261 Cesium cation binding sites [ion binding]; other site 1217737004262 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1217737004263 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1217737004264 ATP binding site [chemical binding]; other site 1217737004265 putative Mg++ binding site [ion binding]; other site 1217737004266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737004267 nucleotide binding region [chemical binding]; other site 1217737004268 ATP-binding site [chemical binding]; other site 1217737004269 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1217737004270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737004271 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1217737004272 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1217737004273 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1217737004274 NADP binding site [chemical binding]; other site 1217737004275 dimer interface [polypeptide binding]; other site 1217737004276 RNA polymerase sigma factor; Provisional; Region: PRK12543 1217737004277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737004278 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737004279 DNA binding residues [nucleotide binding] 1217737004280 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 1217737004281 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1217737004282 ABC1 family; Region: ABC1; cl17513 1217737004283 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 1217737004284 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1217737004285 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737004286 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 1217737004287 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1217737004288 catalytic residues [active] 1217737004289 dimer interface [polypeptide binding]; other site 1217737004290 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1217737004291 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1217737004292 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1217737004293 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1217737004294 Protein of unknown function DUF58; Region: DUF58; pfam01882 1217737004295 MoxR-like ATPases [General function prediction only]; Region: COG0714 1217737004296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737004297 Walker A motif; other site 1217737004298 ATP binding site [chemical binding]; other site 1217737004299 Walker B motif; other site 1217737004300 arginine finger; other site 1217737004301 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1217737004302 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1217737004303 [4Fe-4S] binding site [ion binding]; other site 1217737004304 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1217737004305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1217737004306 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1217737004307 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1217737004308 molybdopterin cofactor binding site; other site 1217737004309 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1217737004310 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1217737004311 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1217737004312 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1217737004313 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1217737004314 ligand binding site [chemical binding]; other site 1217737004315 flexible hinge region; other site 1217737004316 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1217737004317 putative switch regulator; other site 1217737004318 non-specific DNA interactions [nucleotide binding]; other site 1217737004319 DNA binding site [nucleotide binding] 1217737004320 sequence specific DNA binding site [nucleotide binding]; other site 1217737004321 putative cAMP binding site [chemical binding]; other site 1217737004322 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1217737004323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737004324 FeS/SAM binding site; other site 1217737004325 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1217737004326 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1217737004327 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1217737004328 ATP binding site [chemical binding]; other site 1217737004329 substrate interface [chemical binding]; other site 1217737004330 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1217737004331 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1217737004332 dimer interface [polypeptide binding]; other site 1217737004333 putative functional site; other site 1217737004334 putative MPT binding site; other site 1217737004335 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1217737004336 MoaE homodimer interface [polypeptide binding]; other site 1217737004337 MoaD interaction [polypeptide binding]; other site 1217737004338 active site residues [active] 1217737004339 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1217737004340 MoaE interaction surface [polypeptide binding]; other site 1217737004341 MoeB interaction surface [polypeptide binding]; other site 1217737004342 thiocarboxylated glycine; other site 1217737004343 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1217737004344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004345 putative substrate translocation pore; other site 1217737004346 Predicted permeases [General function prediction only]; Region: COG0679 1217737004347 precorrin-2 dehydrogenase; Validated; Region: PRK06719 1217737004348 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1217737004349 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1217737004350 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1217737004351 putative active site [active] 1217737004352 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1217737004353 putative active site [active] 1217737004354 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1217737004355 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1217737004356 active site 1217737004357 SAM binding site [chemical binding]; other site 1217737004358 homodimer interface [polypeptide binding]; other site 1217737004359 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1217737004360 [2Fe-2S] cluster binding site [ion binding]; other site 1217737004361 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1217737004362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737004363 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1217737004364 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1217737004365 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1217737004366 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1217737004367 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1217737004368 Hemerythrin-like domain; Region: Hr-like; cd12108 1217737004369 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1217737004370 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1217737004371 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1217737004372 PGAP1-like protein; Region: PGAP1; pfam07819 1217737004373 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1217737004374 YolD-like protein; Region: YolD; pfam08863 1217737004375 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737004376 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1217737004377 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737004378 Zn2+ binding site [ion binding]; other site 1217737004379 Mg2+ binding site [ion binding]; other site 1217737004380 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737004381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737004382 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737004383 ABC transporter; Region: ABC_tran_2; pfam12848 1217737004384 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737004385 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1217737004386 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 1217737004387 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1217737004388 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1217737004389 dimer interface [polypeptide binding]; other site 1217737004390 ssDNA binding site [nucleotide binding]; other site 1217737004391 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737004392 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1217737004393 Virulence factor; Region: Virulence_fact; pfam13769 1217737004394 HEAT repeats; Region: HEAT_2; pfam13646 1217737004395 HEAT repeats; Region: HEAT_2; pfam13646 1217737004396 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1217737004397 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1217737004398 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1217737004399 Brix domain; Region: Brix; cl00935 1217737004400 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1217737004401 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1217737004402 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1217737004403 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1217737004404 active site 1217737004405 HIGH motif; other site 1217737004406 KMSK motif region; other site 1217737004407 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1217737004408 tRNA binding surface [nucleotide binding]; other site 1217737004409 anticodon binding site; other site 1217737004410 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 1217737004411 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1217737004412 putative metal binding site [ion binding]; other site 1217737004413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737004414 binding surface 1217737004415 TPR motif; other site 1217737004416 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1217737004417 putative active site [active] 1217737004418 TPR repeat; Region: TPR_11; pfam13414 1217737004419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737004420 TPR motif; other site 1217737004421 binding surface 1217737004422 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1217737004423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737004424 binding surface 1217737004425 TPR motif; other site 1217737004426 TPR repeat; Region: TPR_11; pfam13414 1217737004427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737004428 binding surface 1217737004429 TPR motif; other site 1217737004430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737004431 binding surface 1217737004432 TPR motif; other site 1217737004433 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1217737004434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737004435 binding surface 1217737004436 TPR motif; other site 1217737004437 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1217737004438 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1217737004439 HIGH motif; other site 1217737004440 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1217737004441 active site 1217737004442 KMSKS motif; other site 1217737004443 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1217737004444 tRNA binding surface [nucleotide binding]; other site 1217737004445 anticodon binding site; other site 1217737004446 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1217737004447 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1217737004448 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1217737004449 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1217737004450 Zn binding site [ion binding]; other site 1217737004451 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1217737004452 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1217737004453 Dimer interface [polypeptide binding]; other site 1217737004454 anticodon binding site; other site 1217737004455 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1217737004456 homodimer interface [polypeptide binding]; other site 1217737004457 motif 1; other site 1217737004458 motif 2; other site 1217737004459 active site 1217737004460 motif 3; other site 1217737004461 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1217737004462 Na2 binding site [ion binding]; other site 1217737004463 putative substrate binding site 1 [chemical binding]; other site 1217737004464 Na binding site 1 [ion binding]; other site 1217737004465 putative substrate binding site 2 [chemical binding]; other site 1217737004466 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1217737004467 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737004468 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1217737004469 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1217737004470 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1217737004471 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1217737004472 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1217737004473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737004474 motif II; other site 1217737004475 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1217737004476 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1217737004477 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1217737004478 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1217737004479 putative active site [active] 1217737004480 metal binding site [ion binding]; metal-binding site 1217737004481 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1217737004482 aspartate racemase; Region: asp_race; TIGR00035 1217737004483 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1217737004484 homodimer interaction site [polypeptide binding]; other site 1217737004485 cofactor binding site; other site 1217737004486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737004487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004488 Coenzyme A binding pocket [chemical binding]; other site 1217737004489 Predicted transcriptional regulator [Transcription]; Region: COG3655 1217737004490 salt bridge; other site 1217737004491 non-specific DNA binding site [nucleotide binding]; other site 1217737004492 sequence-specific DNA binding site [nucleotide binding]; other site 1217737004493 hypothetical protein; Validated; Region: PRK06769 1217737004494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737004495 active site 1217737004496 motif I; other site 1217737004497 motif II; other site 1217737004498 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737004499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004500 Coenzyme A binding pocket [chemical binding]; other site 1217737004501 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737004502 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737004503 Walker A/P-loop; other site 1217737004504 ATP binding site [chemical binding]; other site 1217737004505 Q-loop/lid; other site 1217737004506 ABC transporter signature motif; other site 1217737004507 Walker B; other site 1217737004508 D-loop; other site 1217737004509 H-loop/switch region; other site 1217737004510 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1217737004511 YpjP-like protein; Region: YpjP; pfam14005 1217737004512 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1217737004513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737004514 motif II; other site 1217737004515 hypothetical protein; Provisional; Region: PRK06724 1217737004516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737004517 active site 1217737004518 metal binding site [ion binding]; metal-binding site 1217737004519 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1217737004520 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737004521 active site 1217737004522 substrate binding site [chemical binding]; other site 1217737004523 ATP binding site [chemical binding]; other site 1217737004524 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737004525 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737004526 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1217737004527 thymidylate synthase; Region: thym_sym; TIGR03284 1217737004528 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1217737004529 dimerization interface [polypeptide binding]; other site 1217737004530 active site 1217737004531 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1217737004532 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1217737004533 folate binding site [chemical binding]; other site 1217737004534 NADP+ binding site [chemical binding]; other site 1217737004535 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1217737004536 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737004537 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1217737004538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737004539 azoreductase; Reviewed; Region: PRK00170 1217737004540 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1217737004541 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1217737004542 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1217737004543 putative acyl-acceptor binding pocket; other site 1217737004544 Haemolysin-III related; Region: HlyIII; cl03831 1217737004545 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1217737004546 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1217737004547 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1217737004548 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1217737004549 EDD domain protein, DegV family; Region: DegV; TIGR00762 1217737004550 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1217737004551 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1217737004552 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1217737004553 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1217737004554 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1217737004555 Cu(I) binding site [ion binding]; other site 1217737004556 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1217737004557 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1217737004558 putative dimer interface [polypeptide binding]; other site 1217737004559 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1217737004560 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1217737004561 active site 1217737004562 dimer interface [polypeptide binding]; other site 1217737004563 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1217737004564 Ligand Binding Site [chemical binding]; other site 1217737004565 Molecular Tunnel; other site 1217737004566 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737004567 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737004568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737004569 active site 1217737004570 metal binding site [ion binding]; metal-binding site 1217737004571 Bacterial SH3 domain; Region: SH3_3; cl17532 1217737004572 Bacterial SH3 domain; Region: SH3_3; cl17532 1217737004573 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1217737004574 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1217737004575 siderophore binding site; other site 1217737004576 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1217737004577 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1217737004578 homodimer interface [polypeptide binding]; other site 1217737004579 substrate-cofactor binding pocket; other site 1217737004580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737004581 catalytic residue [active] 1217737004582 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1217737004583 FMN binding site [chemical binding]; other site 1217737004584 dimer interface [polypeptide binding]; other site 1217737004585 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737004586 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1217737004587 catalytic triad [active] 1217737004588 conserved cis-peptide bond; other site 1217737004589 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1217737004590 nudix motif; other site 1217737004591 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1217737004592 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1217737004593 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1217737004594 GAF domain; Region: GAF; pfam01590 1217737004595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1217737004596 Histidine kinase; Region: HisKA_3; pfam07730 1217737004597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737004598 ATP binding site [chemical binding]; other site 1217737004599 Mg2+ binding site [ion binding]; other site 1217737004600 G-X-G motif; other site 1217737004601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737004602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737004603 active site 1217737004604 phosphorylation site [posttranslational modification] 1217737004605 intermolecular recognition site; other site 1217737004606 dimerization interface [polypeptide binding]; other site 1217737004607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737004608 DNA binding residues [nucleotide binding] 1217737004609 dimerization interface [polypeptide binding]; other site 1217737004610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1217737004611 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1217737004612 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1217737004613 putative active site [active] 1217737004614 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1217737004615 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1217737004616 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1217737004617 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1217737004618 NAD binding site [chemical binding]; other site 1217737004619 substrate binding site [chemical binding]; other site 1217737004620 catalytic Zn binding site [ion binding]; other site 1217737004621 tetramer interface [polypeptide binding]; other site 1217737004622 structural Zn binding site [ion binding]; other site 1217737004623 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1217737004624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737004625 dimer interface [polypeptide binding]; other site 1217737004626 conserved gate region; other site 1217737004627 ABC-ATPase subunit interface; other site 1217737004628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1217737004629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1217737004630 dimer interface [polypeptide binding]; other site 1217737004631 conserved gate region; other site 1217737004632 putative PBP binding loops; other site 1217737004633 ABC-ATPase subunit interface; other site 1217737004634 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1217737004635 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1217737004636 N- and C-terminal domain interface [polypeptide binding]; other site 1217737004637 active site 1217737004638 catalytic site [active] 1217737004639 metal binding site [ion binding]; metal-binding site 1217737004640 carbohydrate binding site [chemical binding]; other site 1217737004641 ATP binding site [chemical binding]; other site 1217737004642 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1217737004643 GntP family permease; Region: GntP_permease; pfam02447 1217737004644 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1217737004645 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1217737004646 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1217737004647 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737004648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737004649 active site 1217737004650 Predicted flavoprotein [General function prediction only]; Region: COG0431 1217737004651 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1217737004652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004653 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737004654 putative substrate translocation pore; other site 1217737004655 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1217737004656 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1217737004657 putative active site [active] 1217737004658 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1217737004659 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1217737004660 Walker A/P-loop; other site 1217737004661 ATP binding site [chemical binding]; other site 1217737004662 Q-loop/lid; other site 1217737004663 ABC transporter signature motif; other site 1217737004664 Walker B; other site 1217737004665 D-loop; other site 1217737004666 H-loop/switch region; other site 1217737004667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737004668 dimer interface [polypeptide binding]; other site 1217737004669 conserved gate region; other site 1217737004670 ABC-ATPase subunit interface; other site 1217737004671 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1217737004672 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1217737004673 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1217737004674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1217737004675 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1217737004676 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1217737004677 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1217737004678 DNA binding residues [nucleotide binding] 1217737004679 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1217737004680 Domain of unknown function DUF21; Region: DUF21; pfam01595 1217737004681 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1217737004682 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1217737004683 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1217737004684 NAD(P) binding site [chemical binding]; other site 1217737004685 catalytic residues [active] 1217737004686 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1217737004687 Histidine kinase N terminal; Region: HisK_N; pfam09385 1217737004688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737004689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737004690 dimer interface [polypeptide binding]; other site 1217737004691 phosphorylation site [posttranslational modification] 1217737004692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737004693 ATP binding site [chemical binding]; other site 1217737004694 Mg2+ binding site [ion binding]; other site 1217737004695 G-X-G motif; other site 1217737004696 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1217737004697 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1217737004698 hypothetical protein; Provisional; Region: PRK06917 1217737004699 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737004700 inhibitor-cofactor binding pocket; inhibition site 1217737004701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737004702 catalytic residue [active] 1217737004703 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1217737004704 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1217737004705 acetylornithine deacetylase; Validated; Region: PRK06915 1217737004706 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1217737004707 metal binding site [ion binding]; metal-binding site 1217737004708 dimer interface [polypeptide binding]; other site 1217737004709 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1217737004710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737004711 PAS domain; Region: PAS; smart00091 1217737004712 PAS fold; Region: PAS_4; pfam08448 1217737004713 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1217737004714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737004715 Walker A motif; other site 1217737004716 ATP binding site [chemical binding]; other site 1217737004717 Walker B motif; other site 1217737004718 arginine finger; other site 1217737004719 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1217737004720 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1217737004721 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737004722 FeS/SAM binding site; other site 1217737004723 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1217737004724 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1217737004725 toxin interface [polypeptide binding]; other site 1217737004726 Zn binding site [ion binding]; other site 1217737004727 hypothetical protein; Provisional; Region: PRK13672 1217737004728 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 1217737004729 YozD-like protein; Region: YozD; pfam14162 1217737004730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1217737004731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1217737004732 active site 1217737004733 ATP binding site [chemical binding]; other site 1217737004734 substrate binding site [chemical binding]; other site 1217737004735 activation loop (A-loop); other site 1217737004736 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1217737004737 SpoOM protein; Region: Spo0M; pfam07070 1217737004738 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1217737004739 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1217737004740 active site 1217737004741 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1217737004742 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1217737004743 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737004744 catalytic residues [active] 1217737004745 C1q domain; Region: C1q; cl17543 1217737004746 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1217737004747 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1217737004748 active site 1217737004749 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1217737004750 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1217737004751 YolD-like protein; Region: YolD; pfam08863 1217737004752 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1217737004753 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1217737004754 classical (c) SDRs; Region: SDR_c; cd05233 1217737004755 NAD(P) binding site [chemical binding]; other site 1217737004756 active site 1217737004757 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1217737004758 KTSC domain; Region: KTSC; pfam13619 1217737004759 Transglycosylase; Region: Transgly; pfam00912 1217737004760 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1217737004761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737004762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737004764 putative substrate translocation pore; other site 1217737004765 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1217737004766 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1217737004767 dimer interface [polypeptide binding]; other site 1217737004768 Citrate synthase; Region: Citrate_synt; pfam00285 1217737004769 active site 1217737004770 coenzyme A binding site [chemical binding]; other site 1217737004771 citrylCoA binding site [chemical binding]; other site 1217737004772 oxalacetate/citrate binding site [chemical binding]; other site 1217737004773 catalytic triad [active] 1217737004774 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1217737004775 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1217737004776 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1217737004777 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1217737004778 tetramer interface [polypeptide binding]; other site 1217737004779 active site 1217737004780 Mg2+/Mn2+ binding site [ion binding]; other site 1217737004781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1217737004782 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1217737004783 active site 1217737004784 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1217737004785 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1217737004786 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1217737004787 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1217737004788 tetrameric interface [polypeptide binding]; other site 1217737004789 NAD binding site [chemical binding]; other site 1217737004790 catalytic residues [active] 1217737004791 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1217737004792 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1217737004793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1217737004794 substrate binding site [chemical binding]; other site 1217737004795 oxyanion hole (OAH) forming residues; other site 1217737004796 trimer interface [polypeptide binding]; other site 1217737004797 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1217737004798 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1217737004799 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1217737004800 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1217737004801 active site 1217737004802 metal binding site [ion binding]; metal-binding site 1217737004803 DNA binding site [nucleotide binding] 1217737004804 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1217737004805 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1217737004806 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1217737004807 Walker A/P-loop; other site 1217737004808 ATP binding site [chemical binding]; other site 1217737004809 Q-loop/lid; other site 1217737004810 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1217737004811 ABC transporter signature motif; other site 1217737004812 Walker B; other site 1217737004813 D-loop; other site 1217737004814 H-loop/switch region; other site 1217737004815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737004816 dimerization interface [polypeptide binding]; other site 1217737004817 putative DNA binding site [nucleotide binding]; other site 1217737004818 putative Zn2+ binding site [ion binding]; other site 1217737004819 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1217737004820 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1217737004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004822 putative substrate translocation pore; other site 1217737004823 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1217737004824 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1217737004825 putative NAD(P) binding site [chemical binding]; other site 1217737004826 active site 1217737004827 isochorismate synthase DhbC; Validated; Region: PRK06923 1217737004828 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1217737004829 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1217737004830 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1217737004831 acyl-activating enzyme (AAE) consensus motif; other site 1217737004832 active site 1217737004833 AMP binding site [chemical binding]; other site 1217737004834 substrate binding site [chemical binding]; other site 1217737004835 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1217737004836 hydrophobic substrate binding pocket; other site 1217737004837 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737004838 active site 1217737004839 conserved cis-peptide bond; other site 1217737004840 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1217737004841 Condensation domain; Region: Condensation; pfam00668 1217737004842 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1217737004843 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1217737004844 acyl-activating enzyme (AAE) consensus motif; other site 1217737004845 AMP binding site [chemical binding]; other site 1217737004846 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737004847 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1217737004848 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737004849 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737004850 acyl-activating enzyme (AAE) consensus motif; other site 1217737004851 AMP binding site [chemical binding]; other site 1217737004852 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737004853 MbtH-like protein; Region: MbtH; pfam03621 1217737004854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737004855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737004856 putative substrate translocation pore; other site 1217737004857 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1217737004858 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1217737004859 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1217737004860 IHF dimer interface [polypeptide binding]; other site 1217737004861 IHF - DNA interface [nucleotide binding]; other site 1217737004862 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1217737004863 DinB family; Region: DinB; cl17821 1217737004864 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1217737004865 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1217737004866 active site 1217737004867 catalytic triad [active] 1217737004868 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737004869 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1217737004870 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1217737004871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737004872 RNA binding surface [nucleotide binding]; other site 1217737004873 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1217737004874 probable active site [active] 1217737004875 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1217737004876 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1217737004877 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1217737004878 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1217737004879 active site 1217737004880 dimer interface [polypeptide binding]; other site 1217737004881 motif 1; other site 1217737004882 motif 2; other site 1217737004883 motif 3; other site 1217737004884 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1217737004885 anticodon binding site; other site 1217737004886 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737004887 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737004888 Walker A/P-loop; other site 1217737004889 ATP binding site [chemical binding]; other site 1217737004890 Q-loop/lid; other site 1217737004891 ABC transporter signature motif; other site 1217737004892 Walker B; other site 1217737004893 D-loop; other site 1217737004894 H-loop/switch region; other site 1217737004895 FtsX-like permease family; Region: FtsX; pfam02687 1217737004896 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1217737004897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737004898 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1217737004899 active site 1217737004900 dimerization interface [polypeptide binding]; other site 1217737004901 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 1217737004902 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1217737004903 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1217737004904 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1217737004905 ligand binding site [chemical binding]; other site 1217737004906 flexible hinge region; other site 1217737004907 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1217737004908 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1217737004909 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1217737004910 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1217737004911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737004912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737004913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737004914 MMPL family; Region: MMPL; pfam03176 1217737004915 MMPL family; Region: MMPL; pfam03176 1217737004916 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 1217737004917 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 1217737004918 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1217737004919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004920 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737004921 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737004922 Coenzyme A binding pocket [chemical binding]; other site 1217737004923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737004924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004925 Coenzyme A binding pocket [chemical binding]; other site 1217737004926 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1217737004927 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1217737004928 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1217737004929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004930 Coenzyme A binding pocket [chemical binding]; other site 1217737004931 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737004932 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1217737004933 EamA-like transporter family; Region: EamA; pfam00892 1217737004934 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1217737004935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737004936 non-specific DNA binding site [nucleotide binding]; other site 1217737004937 salt bridge; other site 1217737004938 sequence-specific DNA binding site [nucleotide binding]; other site 1217737004939 Cupin domain; Region: Cupin_2; pfam07883 1217737004940 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1217737004941 protoporphyrinogen oxidase; Provisional; Region: PRK12416 1217737004942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737004943 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737004944 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737004945 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1217737004946 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737004947 DNA-binding site [nucleotide binding]; DNA binding site 1217737004948 RNA-binding motif; other site 1217737004949 CAAX protease self-immunity; Region: Abi; pfam02517 1217737004950 AAA domain; Region: AAA_17; pfam13207 1217737004951 AAA domain; Region: AAA_18; pfam13238 1217737004952 hypothetical protein; Provisional; Region: PRK06770 1217737004953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737004954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737004955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737004956 dimerization interface [polypeptide binding]; other site 1217737004957 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 1217737004958 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1217737004959 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1217737004960 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1217737004961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737004962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737004963 dimerization interface [polypeptide binding]; other site 1217737004964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1217737004965 MOSC domain; Region: MOSC; pfam03473 1217737004966 3-alpha domain; Region: 3-alpha; pfam03475 1217737004967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737004968 Coenzyme A binding pocket [chemical binding]; other site 1217737004969 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1217737004970 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737004971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737004972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737004973 Walker A/P-loop; other site 1217737004974 ATP binding site [chemical binding]; other site 1217737004975 Q-loop/lid; other site 1217737004976 ABC transporter signature motif; other site 1217737004977 Walker B; other site 1217737004978 D-loop; other site 1217737004979 H-loop/switch region; other site 1217737004980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737004981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737004982 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1217737004983 Walker A/P-loop; other site 1217737004984 ATP binding site [chemical binding]; other site 1217737004985 Q-loop/lid; other site 1217737004986 ABC transporter signature motif; other site 1217737004987 Walker B; other site 1217737004988 D-loop; other site 1217737004989 H-loop/switch region; other site 1217737004990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737004991 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1217737004992 LysE type translocator; Region: LysE; cl00565 1217737004993 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1217737004994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737004995 non-specific DNA binding site [nucleotide binding]; other site 1217737004996 salt bridge; other site 1217737004997 sequence-specific DNA binding site [nucleotide binding]; other site 1217737004998 Cupin domain; Region: Cupin_2; pfam07883 1217737004999 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1217737005000 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1217737005001 Cupin; Region: Cupin_1; smart00835 1217737005002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737005003 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1217737005004 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1217737005005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737005006 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1217737005007 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1217737005008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005009 S-adenosylmethionine binding site [chemical binding]; other site 1217737005010 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1217737005011 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 1217737005012 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1217737005013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1217737005014 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1217737005015 active site 1217737005016 P-loop; other site 1217737005017 phosphorylation site [posttranslational modification] 1217737005018 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1217737005019 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1217737005020 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1217737005021 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1217737005022 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1217737005023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1217737005024 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1217737005025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737005026 catalytic residue [active] 1217737005027 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1217737005028 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1217737005029 tetramer interface [polypeptide binding]; other site 1217737005030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005031 catalytic residue [active] 1217737005032 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737005033 MarR family; Region: MarR; pfam01047 1217737005034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737005036 putative substrate translocation pore; other site 1217737005037 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1217737005038 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737005039 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1217737005040 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1217737005041 ATP binding site [chemical binding]; other site 1217737005042 Mg++ binding site [ion binding]; other site 1217737005043 motif III; other site 1217737005044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737005045 nucleotide binding region [chemical binding]; other site 1217737005046 ATP-binding site [chemical binding]; other site 1217737005047 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737005048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005049 S-adenosylmethionine binding site [chemical binding]; other site 1217737005050 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1217737005051 dimer interface [polypeptide binding]; other site 1217737005052 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737005053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005054 S-adenosylmethionine binding site [chemical binding]; other site 1217737005055 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1217737005056 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1217737005057 TPP-binding site [chemical binding]; other site 1217737005058 dimer interface [polypeptide binding]; other site 1217737005059 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1217737005060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737005061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737005062 putative DNA binding site [nucleotide binding]; other site 1217737005063 putative Zn2+ binding site [ion binding]; other site 1217737005064 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737005065 catalytic core [active] 1217737005066 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737005067 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1217737005068 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737005069 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1217737005070 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1217737005071 metal binding site [ion binding]; metal-binding site 1217737005072 dimer interface [polypeptide binding]; other site 1217737005073 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1217737005074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737005075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737005076 DNA binding residues [nucleotide binding] 1217737005077 dimerization interface [polypeptide binding]; other site 1217737005078 potential frameshift: common BLAST hit: gi|384186480|ref|YP_005572376.1| XRE family transcriptional regulator 1217737005079 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1217737005080 hypothetical protein; Provisional; Region: PRK10621 1217737005081 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737005082 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1217737005083 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1217737005084 trimer interface [polypeptide binding]; other site 1217737005085 active site 1217737005086 substrate binding site [chemical binding]; other site 1217737005087 CoA binding site [chemical binding]; other site 1217737005088 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1217737005089 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737005090 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1217737005091 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1217737005092 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1217737005093 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1217737005094 active site 1217737005095 catalytic triad [active] 1217737005096 oxyanion hole [active] 1217737005097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005098 putative substrate translocation pore; other site 1217737005099 Condensation domain; Region: Condensation; pfam00668 1217737005100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005101 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737005102 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005103 acyl-activating enzyme (AAE) consensus motif; other site 1217737005104 AMP binding site [chemical binding]; other site 1217737005105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005106 Condensation domain; Region: Condensation; pfam00668 1217737005107 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005108 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1217737005109 Condensation domain; Region: Condensation; pfam00668 1217737005110 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005111 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005112 acyl-activating enzyme (AAE) consensus motif; other site 1217737005113 AMP binding site [chemical binding]; other site 1217737005114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005115 Condensation domain; Region: Condensation; pfam00668 1217737005116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737005118 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1217737005119 acyl-activating enzyme (AAE) consensus motif; other site 1217737005120 AMP binding site [chemical binding]; other site 1217737005121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005122 Condensation domain; Region: Condensation; pfam00668 1217737005123 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005124 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737005125 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005126 acyl-activating enzyme (AAE) consensus motif; other site 1217737005127 AMP binding site [chemical binding]; other site 1217737005128 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005129 peptide synthase; Provisional; Region: PRK12467 1217737005130 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737005131 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005132 acyl-activating enzyme (AAE) consensus motif; other site 1217737005133 AMP binding site [chemical binding]; other site 1217737005134 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1217737005136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005137 acyl-activating enzyme (AAE) consensus motif; other site 1217737005138 AMP binding site [chemical binding]; other site 1217737005139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005140 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1217737005141 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005142 acyl-activating enzyme (AAE) consensus motif; other site 1217737005143 AMP binding site [chemical binding]; other site 1217737005144 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005145 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1217737005146 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1217737005147 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1217737005148 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1217737005149 short chain dehydrogenase; Provisional; Region: PRK12747 1217737005150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737005151 NAD(P) binding site [chemical binding]; other site 1217737005152 active site 1217737005153 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 1217737005154 potential frameshift: common BLAST hit: gi|169830095|ref|YP_001700253.1| kinase-like protein 1217737005155 RNA ligase; Region: RNA_ligase; pfam09414 1217737005156 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1217737005157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1217737005158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1217737005159 catalytic residue [active] 1217737005160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737005161 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737005162 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1217737005163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005164 Coenzyme A binding pocket [chemical binding]; other site 1217737005165 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1217737005166 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1217737005167 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1217737005168 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1217737005169 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1217737005170 inhibitor-cofactor binding pocket; inhibition site 1217737005171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005172 catalytic residue [active] 1217737005173 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737005174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737005175 NAD(P) binding site [chemical binding]; other site 1217737005176 active site 1217737005177 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1217737005178 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1217737005179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737005180 catalytic residue [active] 1217737005181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1217737005182 WbqC-like protein family; Region: WbqC; pfam08889 1217737005183 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1217737005184 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1217737005185 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1217737005186 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1217737005187 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1217737005188 PA/protease or protease-like domain interface [polypeptide binding]; other site 1217737005189 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1217737005190 Peptidase family M28; Region: Peptidase_M28; pfam04389 1217737005191 metal binding site [ion binding]; metal-binding site 1217737005192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737005194 putative substrate translocation pore; other site 1217737005195 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1217737005196 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1217737005197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737005198 dimerization interface [polypeptide binding]; other site 1217737005199 putative DNA binding site [nucleotide binding]; other site 1217737005200 putative Zn2+ binding site [ion binding]; other site 1217737005201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1217737005202 TPR motif; other site 1217737005203 binding surface 1217737005204 S-layer homology domain; Region: SLH; pfam00395 1217737005205 S-layer homology domain; Region: SLH; pfam00395 1217737005206 S-layer homology domain; Region: SLH; pfam00395 1217737005207 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1217737005208 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1217737005209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737005210 non-specific DNA binding site [nucleotide binding]; other site 1217737005211 salt bridge; other site 1217737005212 sequence-specific DNA binding site [nucleotide binding]; other site 1217737005213 Cupin domain; Region: Cupin_2; pfam07883 1217737005214 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1217737005215 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1217737005216 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737005217 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1217737005218 NodB motif; other site 1217737005219 active site 1217737005220 catalytic site [active] 1217737005221 Zn binding site [ion binding]; other site 1217737005222 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1217737005223 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1217737005224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005225 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1217737005226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737005227 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1217737005228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737005229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737005230 DNA binding residues [nucleotide binding] 1217737005231 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1217737005232 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005233 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737005234 Homeodomain-like domain; Region: HTH_23; cl17451 1217737005235 putative transposase OrfB; Reviewed; Region: PHA02517 1217737005236 HTH-like domain; Region: HTH_21; pfam13276 1217737005237 Integrase core domain; Region: rve; pfam00665 1217737005238 Integrase core domain; Region: rve_2; pfam13333 1217737005239 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737005240 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005241 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737005243 beta-lactamase TEM; Provisional; Region: PRK15442 1217737005244 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1217737005245 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1217737005246 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737005247 putative active site [active] 1217737005248 putative metal binding site [ion binding]; other site 1217737005249 potential frameshift: common BLAST hit: gi|218897492|ref|YP_002445903.1| ABC transporter ATP-binding protein 1217737005250 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1217737005251 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1217737005252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737005253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737005254 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1217737005255 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1217737005256 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1217737005257 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1217737005258 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1217737005259 FAD binding site [chemical binding]; other site 1217737005260 homotetramer interface [polypeptide binding]; other site 1217737005261 substrate binding pocket [chemical binding]; other site 1217737005262 catalytic base [active] 1217737005263 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1217737005264 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1217737005265 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1217737005266 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1217737005267 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1217737005268 carboxyltransferase (CT) interaction site; other site 1217737005269 biotinylation site [posttranslational modification]; other site 1217737005270 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1217737005271 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1217737005272 active site 1217737005273 catalytic residues [active] 1217737005274 metal binding site [ion binding]; metal-binding site 1217737005275 enoyl-CoA hydratase; Provisional; Region: PRK07657 1217737005276 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1217737005277 substrate binding site [chemical binding]; other site 1217737005278 oxyanion hole (OAH) forming residues; other site 1217737005279 trimer interface [polypeptide binding]; other site 1217737005280 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1217737005281 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1217737005282 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1217737005283 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1217737005284 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 1217737005285 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 1217737005286 acyl-activating enzyme (AAE) consensus motif; other site 1217737005287 putative AMP binding site [chemical binding]; other site 1217737005288 putative active site [active] 1217737005289 putative CoA binding site [chemical binding]; other site 1217737005290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737005291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005292 Coenzyme A binding pocket [chemical binding]; other site 1217737005293 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 1217737005294 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1217737005295 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737005296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737005297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737005298 dimer interface [polypeptide binding]; other site 1217737005299 phosphorylation site [posttranslational modification] 1217737005300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737005301 ATP binding site [chemical binding]; other site 1217737005302 Mg2+ binding site [ion binding]; other site 1217737005303 G-X-G motif; other site 1217737005304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737005305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737005306 active site 1217737005307 phosphorylation site [posttranslational modification] 1217737005308 intermolecular recognition site; other site 1217737005309 dimerization interface [polypeptide binding]; other site 1217737005310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737005311 DNA binding site [nucleotide binding] 1217737005312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737005313 Zn2+ binding site [ion binding]; other site 1217737005314 Mg2+ binding site [ion binding]; other site 1217737005315 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1217737005316 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 1217737005317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005318 Coenzyme A binding pocket [chemical binding]; other site 1217737005319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1217737005320 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1217737005321 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1217737005322 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1217737005323 active site 1217737005324 Zn binding site [ion binding]; other site 1217737005325 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1217737005326 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1217737005327 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1217737005328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1217737005329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737005330 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737005331 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737005332 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737005333 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1217737005334 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1217737005335 active site 1217737005336 catalytic site [active] 1217737005337 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1217737005338 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737005339 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737005340 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737005341 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737005342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1217737005343 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1217737005344 putative hydrophobic ligand binding site [chemical binding]; other site 1217737005345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737005346 AAA domain; Region: AAA_21; pfam13304 1217737005347 Walker A/P-loop; other site 1217737005348 ATP binding site [chemical binding]; other site 1217737005349 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 1217737005350 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 1217737005351 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1217737005352 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1217737005353 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1217737005354 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737005355 DNA binding residues [nucleotide binding] 1217737005356 drug binding residues [chemical binding]; other site 1217737005357 dimer interface [polypeptide binding]; other site 1217737005358 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1217737005359 short chain dehydrogenase; Provisional; Region: PRK07041 1217737005360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737005361 NAD(P) binding site [chemical binding]; other site 1217737005362 active site 1217737005363 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737005364 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1217737005365 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737005366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005367 S-adenosylmethionine binding site [chemical binding]; other site 1217737005368 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1217737005369 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1217737005370 active site 1217737005371 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737005372 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1217737005373 active site 1217737005374 substrate binding site [chemical binding]; other site 1217737005375 ATP binding site [chemical binding]; other site 1217737005376 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737005377 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737005378 active site 1217737005379 ATP binding site [chemical binding]; other site 1217737005380 substrate binding site [chemical binding]; other site 1217737005381 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1217737005382 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1217737005383 active site 1217737005384 Zn binding site [ion binding]; other site 1217737005385 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 1217737005386 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737005388 DNA-binding site [nucleotide binding]; DNA binding site 1217737005389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737005390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005391 homodimer interface [polypeptide binding]; other site 1217737005392 catalytic residue [active] 1217737005393 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1217737005394 potential frameshift: common BLAST hit: gi|30020657|ref|NP_832288.1| Zn-dependent alcohol dehydrogenase and related dehydrogenase 1217737005395 Predicted membrane protein [Function unknown]; Region: COG2323 1217737005396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005397 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1217737005398 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1217737005399 conserved cys residue [active] 1217737005400 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737005401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005402 S-adenosylmethionine binding site [chemical binding]; other site 1217737005403 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1217737005404 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1217737005405 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 1217737005406 active site 1217737005407 HIGH motif; other site 1217737005408 KMSKS motif; other site 1217737005409 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1217737005410 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1217737005411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737005412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737005413 active site 1217737005414 phosphorylation site [posttranslational modification] 1217737005415 intermolecular recognition site; other site 1217737005416 dimerization interface [polypeptide binding]; other site 1217737005417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737005418 DNA binding site [nucleotide binding] 1217737005419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737005420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1217737005421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737005422 ATP binding site [chemical binding]; other site 1217737005423 Mg2+ binding site [ion binding]; other site 1217737005424 G-X-G motif; other site 1217737005425 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1217737005426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737005427 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1217737005428 dimerization interface [polypeptide binding]; other site 1217737005429 substrate binding pocket [chemical binding]; other site 1217737005430 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737005431 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737005432 active site 1217737005433 catalytic tetrad [active] 1217737005434 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737005435 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737005436 ABC transporter; Region: ABC_tran_2; pfam12848 1217737005437 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737005438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737005439 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737005440 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737005441 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737005442 Walker A/P-loop; other site 1217737005443 ATP binding site [chemical binding]; other site 1217737005444 Q-loop/lid; other site 1217737005445 ABC transporter signature motif; other site 1217737005446 Walker B; other site 1217737005447 D-loop; other site 1217737005448 H-loop/switch region; other site 1217737005449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737005450 FtsX-like permease family; Region: FtsX; pfam02687 1217737005451 hypothetical protein; Provisional; Region: PRK06760 1217737005452 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 1217737005453 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1217737005454 homoserine dehydrogenase; Validated; Region: PRK06813 1217737005455 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1217737005456 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737005457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737005458 DNA-binding site [nucleotide binding]; DNA binding site 1217737005459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005461 homodimer interface [polypeptide binding]; other site 1217737005462 catalytic residue [active] 1217737005463 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1217737005464 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1217737005465 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1217737005466 Putative transcription activator [Transcription]; Region: TenA; COG0819 1217737005467 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 1217737005468 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 1217737005469 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 1217737005470 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 1217737005471 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 1217737005472 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1217737005473 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1217737005474 Protein of unknown function; Region: DUF3658; pfam12395 1217737005475 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1217737005476 Cytochrome P450; Region: p450; cl12078 1217737005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005478 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737005479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005480 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1217737005481 trimer interface [polypeptide binding]; other site 1217737005482 active site 1217737005483 substrate binding site [chemical binding]; other site 1217737005484 CoA binding site [chemical binding]; other site 1217737005485 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1217737005486 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737005487 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737005488 Cytochrome P450; Region: p450; cl12078 1217737005489 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1217737005490 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1217737005491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737005492 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737005493 active site 1217737005494 motif I; other site 1217737005495 motif II; other site 1217737005496 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1217737005497 PAS domain S-box; Region: sensory_box; TIGR00229 1217737005498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737005499 putative active site [active] 1217737005500 heme pocket [chemical binding]; other site 1217737005501 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1217737005502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737005503 dimer interface [polypeptide binding]; other site 1217737005504 phosphorylation site [posttranslational modification] 1217737005505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737005506 ATP binding site [chemical binding]; other site 1217737005507 Mg2+ binding site [ion binding]; other site 1217737005508 G-X-G motif; other site 1217737005509 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737005510 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005511 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005512 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737005513 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1217737005514 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737005515 Catalytic site [active] 1217737005516 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1217737005517 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1217737005518 active site 1217737005519 TDP-binding site; other site 1217737005520 acceptor substrate-binding pocket; other site 1217737005521 homodimer interface [polypeptide binding]; other site 1217737005522 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1217737005523 aspartate racemase; Region: asp_race; TIGR00035 1217737005524 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1217737005525 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1217737005526 active site 1217737005527 catalytic residues [active] 1217737005528 DNA binding site [nucleotide binding] 1217737005529 Int/Topo IB signature motif; other site 1217737005530 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1217737005531 active site 1217737005532 catalytic residues [active] 1217737005533 DNA binding site [nucleotide binding] 1217737005534 Int/Topo IB signature motif; other site 1217737005535 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 1217737005536 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1217737005537 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1217737005538 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 1217737005539 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1217737005540 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1217737005541 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1217737005542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737005543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737005544 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1217737005545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737005546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737005547 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1217737005548 Cupin domain; Region: Cupin_2; cl17218 1217737005549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737005550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737005551 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1217737005552 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737005553 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1217737005554 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1217737005555 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1217737005556 substrate binding site [chemical binding]; other site 1217737005557 catalytic Zn binding site [ion binding]; other site 1217737005558 NAD binding site [chemical binding]; other site 1217737005559 structural Zn binding site [ion binding]; other site 1217737005560 dimer interface [polypeptide binding]; other site 1217737005561 S-formylglutathione hydrolase; Region: PLN02442 1217737005562 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1217737005563 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1217737005564 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1217737005565 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1217737005566 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1217737005567 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1217737005568 Guanylyl transferase CofC like; Region: CofC; cl17472 1217737005569 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737005570 dimerization interface [polypeptide binding]; other site 1217737005571 putative DNA binding site [nucleotide binding]; other site 1217737005572 putative Zn2+ binding site [ion binding]; other site 1217737005573 Carbonic anhydrase; Region: Pro_CA; pfam00484 1217737005574 zinc binding site [ion binding]; other site 1217737005575 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1217737005576 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1217737005577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005578 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1217737005579 putative substrate translocation pore; other site 1217737005580 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737005581 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1217737005582 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1217737005583 DNA photolyase; Region: DNA_photolyase; pfam00875 1217737005584 TspO/MBR family; Region: TspO_MBR; pfam03073 1217737005585 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1217737005586 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1217737005587 Homeodomain-like domain; Region: HTH_23; cl17451 1217737005588 putative transposase OrfB; Reviewed; Region: PHA02517 1217737005589 HTH-like domain; Region: HTH_21; pfam13276 1217737005590 Integrase core domain; Region: rve; pfam00665 1217737005591 Integrase core domain; Region: rve_2; pfam13333 1217737005592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737005593 dimerization interface [polypeptide binding]; other site 1217737005594 putative DNA binding site [nucleotide binding]; other site 1217737005595 putative Zn2+ binding site [ion binding]; other site 1217737005596 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1217737005597 TIGR01777 family protein; Region: yfcH 1217737005598 putative NAD(P) binding site [chemical binding]; other site 1217737005599 putative active site [active] 1217737005600 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1217737005601 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1217737005602 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1217737005603 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1217737005604 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1217737005605 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1217737005606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737005607 FeS/SAM binding site; other site 1217737005608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737005609 non-specific DNA binding site [nucleotide binding]; other site 1217737005610 salt bridge; other site 1217737005611 sequence-specific DNA binding site [nucleotide binding]; other site 1217737005612 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1217737005613 active site 1217737005614 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1217737005615 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1217737005616 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1217737005617 Walker A/P-loop; other site 1217737005618 ATP binding site [chemical binding]; other site 1217737005619 Q-loop/lid; other site 1217737005620 ABC transporter signature motif; other site 1217737005621 Walker B; other site 1217737005622 D-loop; other site 1217737005623 H-loop/switch region; other site 1217737005624 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1217737005625 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1217737005626 Walker A/P-loop; other site 1217737005627 ATP binding site [chemical binding]; other site 1217737005628 Q-loop/lid; other site 1217737005629 ABC transporter signature motif; other site 1217737005630 Walker B; other site 1217737005631 D-loop; other site 1217737005632 H-loop/switch region; other site 1217737005633 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1217737005634 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1217737005635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737005636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737005637 dimer interface [polypeptide binding]; other site 1217737005638 phosphorylation site [posttranslational modification] 1217737005639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737005640 ATP binding site [chemical binding]; other site 1217737005641 Mg2+ binding site [ion binding]; other site 1217737005642 G-X-G motif; other site 1217737005643 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 1217737005644 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1217737005645 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1217737005646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737005647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737005648 putative transporter; Provisional; Region: PRK11021 1217737005649 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1217737005650 nudix motif; other site 1217737005651 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1217737005652 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1217737005653 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1217737005654 active site 1217737005655 ATP binding site [chemical binding]; other site 1217737005656 substrate binding site [chemical binding]; other site 1217737005657 activation loop (A-loop); other site 1217737005658 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1217737005659 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1217737005660 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1217737005661 NAD(P) binding site [chemical binding]; other site 1217737005662 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1217737005663 active site 1217737005664 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1217737005665 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737005666 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737005667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737005668 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1217737005669 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1217737005670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005671 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737005672 putative substrate translocation pore; other site 1217737005673 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737005674 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737005675 VanZ like family; Region: VanZ; pfam04892 1217737005676 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 1217737005677 EDD domain protein, DegV family; Region: DegV; TIGR00762 1217737005678 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1217737005679 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1217737005680 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737005681 DNA binding residues [nucleotide binding] 1217737005682 Trm112p-like protein; Region: Trm112p; pfam03966 1217737005683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005684 S-adenosylmethionine binding site [chemical binding]; other site 1217737005685 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737005686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005687 potential frameshift: common BLAST hit: gi|218897683|ref|YP_002446094.1| GNAT family acetyltransferase 1217737005688 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1217737005689 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1217737005690 active site 1217737005691 catalytic site [active] 1217737005692 metal binding site [ion binding]; metal-binding site 1217737005693 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1217737005694 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737005695 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737005696 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 1217737005697 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737005698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737005699 DNA-binding site [nucleotide binding]; DNA binding site 1217737005700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737005701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005702 homodimer interface [polypeptide binding]; other site 1217737005703 catalytic residue [active] 1217737005704 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737005705 EamA-like transporter family; Region: EamA; pfam00892 1217737005706 EamA-like transporter family; Region: EamA; pfam00892 1217737005707 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1217737005708 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1217737005709 active site 1217737005710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1217737005711 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 1217737005712 nudix motif; other site 1217737005713 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 1217737005714 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737005715 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737005716 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1217737005717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737005718 putative substrate translocation pore; other site 1217737005719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737005720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005721 Coenzyme A binding pocket [chemical binding]; other site 1217737005722 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1217737005723 nudix motif; other site 1217737005724 DNA polymerase III subunit beta; Validated; Region: PRK06673 1217737005725 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1217737005726 putative DNA binding surface [nucleotide binding]; other site 1217737005727 dimer interface [polypeptide binding]; other site 1217737005728 beta-clamp/clamp loader binding surface; other site 1217737005729 beta-clamp/translesion DNA polymerase binding surface; other site 1217737005730 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1217737005731 putative active site [active] 1217737005732 nucleotide binding site [chemical binding]; other site 1217737005733 nudix motif; other site 1217737005734 putative metal binding site [ion binding]; other site 1217737005735 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1217737005736 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1217737005737 translation initiation factor IF-2; Provisional; Region: PRK14845 1217737005738 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1217737005739 homotrimer interaction site [polypeptide binding]; other site 1217737005740 putative active site [active] 1217737005741 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1217737005742 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1217737005743 YxiJ-like protein; Region: YxiJ; pfam14176 1217737005744 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1217737005745 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1217737005746 active site 1217737005747 nucleophile elbow; other site 1217737005748 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1217737005749 pentamer interface [polypeptide binding]; other site 1217737005750 dodecaamer interface [polypeptide binding]; other site 1217737005751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005752 Coenzyme A binding pocket [chemical binding]; other site 1217737005753 metal-dependent hydrolase; Provisional; Region: PRK13291 1217737005754 DinB superfamily; Region: DinB_2; pfam12867 1217737005755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737005756 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737005757 potential frameshift: common BLAST hit: gi|30020832|ref|NP_832463.1| NADPH-dependent glutamate synthase beta chain and related 1217737005758 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1217737005759 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1217737005760 GIY-YIG motif/motif A; other site 1217737005761 active site 1217737005762 catalytic site [active] 1217737005763 putative DNA binding site [nucleotide binding]; other site 1217737005764 metal binding site [ion binding]; metal-binding site 1217737005765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737005766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005767 Coenzyme A binding pocket [chemical binding]; other site 1217737005768 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1217737005769 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737005770 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737005771 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1217737005772 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1217737005773 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1217737005774 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1217737005775 active site 1217737005776 ATP binding site [chemical binding]; other site 1217737005777 substrate binding site [chemical binding]; other site 1217737005778 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1217737005779 nudix motif; other site 1217737005780 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1217737005781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737005782 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1217737005783 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1217737005784 MepB protein; Region: MepB; pfam08877 1217737005785 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1217737005786 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1217737005787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737005788 motif II; other site 1217737005789 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1217737005790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737005791 active site 1217737005792 phosphorylation site [posttranslational modification] 1217737005793 intermolecular recognition site; other site 1217737005794 dimerization interface [polypeptide binding]; other site 1217737005795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737005796 DNA binding site [nucleotide binding] 1217737005797 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1217737005798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737005799 dimerization interface [polypeptide binding]; other site 1217737005800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737005801 dimer interface [polypeptide binding]; other site 1217737005802 phosphorylation site [posttranslational modification] 1217737005803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737005804 ATP binding site [chemical binding]; other site 1217737005805 Mg2+ binding site [ion binding]; other site 1217737005806 G-X-G motif; other site 1217737005807 DinB superfamily; Region: DinB_2; pfam12867 1217737005808 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1217737005809 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737005810 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737005811 Walker A/P-loop; other site 1217737005812 ATP binding site [chemical binding]; other site 1217737005813 Q-loop/lid; other site 1217737005814 ABC transporter signature motif; other site 1217737005815 Walker B; other site 1217737005816 D-loop; other site 1217737005817 H-loop/switch region; other site 1217737005818 FtsX-like permease family; Region: FtsX; pfam02687 1217737005819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737005820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1217737005821 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1217737005822 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737005823 tyrosine decarboxylase; Region: PLN02880 1217737005824 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1217737005825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005826 catalytic residue [active] 1217737005827 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737005828 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1217737005829 acyl-activating enzyme (AAE) consensus motif; other site 1217737005830 AMP binding site [chemical binding]; other site 1217737005831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005832 Condensation domain; Region: Condensation; pfam00668 1217737005833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005834 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1217737005835 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1217737005836 acyl-activating enzyme (AAE) consensus motif; other site 1217737005837 AMP binding site [chemical binding]; other site 1217737005838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737005839 Condensation domain; Region: Condensation; pfam00668 1217737005840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1217737005841 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1217737005842 putative FMN binding site [chemical binding]; other site 1217737005843 NADPH bind site [chemical binding]; other site 1217737005844 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1217737005845 carbohydrate binding site [chemical binding]; other site 1217737005846 pullulanase, type I; Region: pulA_typeI; TIGR02104 1217737005847 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1217737005848 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1217737005849 Ca binding site [ion binding]; other site 1217737005850 active site 1217737005851 catalytic site [active] 1217737005852 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1217737005853 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1217737005854 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1217737005855 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1217737005856 active site 1217737005857 Zn binding site [ion binding]; other site 1217737005858 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1217737005859 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1217737005860 active site 1217737005861 metal binding site [ion binding]; metal-binding site 1217737005862 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1217737005863 DinB superfamily; Region: DinB_2; pfam12867 1217737005864 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1217737005865 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 1217737005866 putative metal binding site [ion binding]; other site 1217737005867 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737005868 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 1217737005869 SecY translocase; Region: SecY; pfam00344 1217737005870 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1217737005871 EamA-like transporter family; Region: EamA; pfam00892 1217737005872 EamA-like transporter family; Region: EamA; pfam00892 1217737005873 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737005874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737005875 DNA-binding site [nucleotide binding]; DNA binding site 1217737005876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737005877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737005878 homodimer interface [polypeptide binding]; other site 1217737005879 catalytic residue [active] 1217737005880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1217737005881 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737005882 TAP-like protein; Region: Abhydrolase_4; pfam08386 1217737005883 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1217737005884 Mg binding site [ion binding]; other site 1217737005885 nucleotide binding site [chemical binding]; other site 1217737005886 putative protofilament interface [polypeptide binding]; other site 1217737005887 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1217737005888 Predicted membrane protein [Function unknown]; Region: COG4129 1217737005889 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1217737005890 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737005891 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1217737005892 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1217737005893 germination protein YpeB; Region: spore_YpeB; TIGR02889 1217737005894 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1217737005895 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1217737005896 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1217737005897 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1217737005898 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737005899 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737005900 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1217737005901 arylformamidase; Region: trp_arylform; TIGR03035 1217737005902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1217737005903 kynureninase; Region: kynureninase; TIGR01814 1217737005904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737005905 catalytic residue [active] 1217737005906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737005907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737005908 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1217737005909 nudix motif; other site 1217737005910 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 1217737005911 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1217737005912 GAF domain; Region: GAF; pfam01590 1217737005913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737005914 Walker A motif; other site 1217737005915 ATP binding site [chemical binding]; other site 1217737005916 Walker B motif; other site 1217737005917 arginine finger; other site 1217737005918 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1217737005919 NIPSNAP; Region: NIPSNAP; pfam07978 1217737005920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1217737005921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737005922 Coenzyme A binding pocket [chemical binding]; other site 1217737005923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1217737005924 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1217737005925 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1217737005926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737005927 S-adenosylmethionine binding site [chemical binding]; other site 1217737005928 Rrf2 family protein; Region: rrf2_super; TIGR00738 1217737005929 Transcriptional regulator; Region: Rrf2; pfam02082 1217737005930 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 1217737005931 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1217737005932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737005933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737005934 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1217737005935 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1217737005936 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1217737005937 E3 interaction surface; other site 1217737005938 lipoyl attachment site [posttranslational modification]; other site 1217737005939 e3 binding domain; Region: E3_binding; pfam02817 1217737005940 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1217737005941 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1217737005942 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1217737005943 alpha subunit interface [polypeptide binding]; other site 1217737005944 TPP binding site [chemical binding]; other site 1217737005945 heterodimer interface [polypeptide binding]; other site 1217737005946 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1217737005947 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1217737005948 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1217737005949 tetramer interface [polypeptide binding]; other site 1217737005950 TPP-binding site [chemical binding]; other site 1217737005951 heterodimer interface [polypeptide binding]; other site 1217737005952 phosphorylation loop region [posttranslational modification] 1217737005953 DinB superfamily; Region: DinB_2; pfam12867 1217737005954 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1217737005955 short chain dehydrogenase; Provisional; Region: PRK06914 1217737005956 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1217737005957 NADP binding site [chemical binding]; other site 1217737005958 active site 1217737005959 steroid binding site; other site 1217737005960 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1217737005961 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1217737005962 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1217737005963 nudix motif; other site 1217737005964 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1217737005965 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1217737005966 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1217737005967 nucleotide binding site/active site [active] 1217737005968 HIT family signature motif; other site 1217737005969 catalytic residue [active] 1217737005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737005971 dimer interface [polypeptide binding]; other site 1217737005972 conserved gate region; other site 1217737005973 putative PBP binding loops; other site 1217737005974 ABC-ATPase subunit interface; other site 1217737005975 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1217737005976 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1217737005977 Walker A/P-loop; other site 1217737005978 ATP binding site [chemical binding]; other site 1217737005979 Q-loop/lid; other site 1217737005980 ABC transporter signature motif; other site 1217737005981 Walker B; other site 1217737005982 D-loop; other site 1217737005983 H-loop/switch region; other site 1217737005984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1217737005985 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1217737005986 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1217737005987 Clp protease; Region: CLP_protease; pfam00574 1217737005988 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1217737005989 oligomer interface [polypeptide binding]; other site 1217737005990 active site residues [active] 1217737005991 RNA polymerase factor sigma-70; Validated; Region: PRK06704 1217737005992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737005993 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1217737005994 DNA binding residues [nucleotide binding] 1217737005995 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1217737005996 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1217737005997 catalytic loop [active] 1217737005998 iron binding site [ion binding]; other site 1217737005999 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1217737006000 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737006001 active site 1217737006002 dimer interface [polypeptide binding]; other site 1217737006003 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1217737006004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006005 Coenzyme A binding pocket [chemical binding]; other site 1217737006006 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1217737006007 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1217737006008 Interdomain contacts; other site 1217737006009 Cytokine receptor motif; other site 1217737006010 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1217737006011 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1217737006012 Interdomain contacts; other site 1217737006013 Cytokine receptor motif; other site 1217737006014 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1217737006015 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1217737006016 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1217737006017 active site 1217737006018 TDP-binding site; other site 1217737006019 acceptor substrate-binding pocket; other site 1217737006020 homodimer interface [polypeptide binding]; other site 1217737006021 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1217737006022 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1217737006023 topology modulation protein; Reviewed; Region: PRK08118 1217737006024 AAA domain; Region: AAA_17; pfam13207 1217737006025 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737006026 active site 1217737006027 ATP binding site [chemical binding]; other site 1217737006028 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1217737006029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737006030 S-adenosylmethionine binding site [chemical binding]; other site 1217737006031 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1217737006032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006033 Coenzyme A binding pocket [chemical binding]; other site 1217737006034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006035 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737006036 Coenzyme A binding pocket [chemical binding]; other site 1217737006037 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1217737006038 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1217737006039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006040 Coenzyme A binding pocket [chemical binding]; other site 1217737006041 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737006042 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737006043 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1217737006044 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1217737006045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006046 Coenzyme A binding pocket [chemical binding]; other site 1217737006047 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1217737006048 Part of AAA domain; Region: AAA_19; pfam13245 1217737006049 Family description; Region: UvrD_C_2; pfam13538 1217737006050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737006051 S-adenosylmethionine binding site [chemical binding]; other site 1217737006052 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1217737006053 putative active site pocket [active] 1217737006054 dimerization interface [polypeptide binding]; other site 1217737006055 putative catalytic residue [active] 1217737006056 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1217737006057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737006058 ATP binding site [chemical binding]; other site 1217737006059 putative Mg++ binding site [ion binding]; other site 1217737006060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737006061 nucleotide binding region [chemical binding]; other site 1217737006062 ATP-binding site [chemical binding]; other site 1217737006063 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1217737006064 HRDC domain; Region: HRDC; pfam00570 1217737006065 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1217737006066 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1217737006067 active site 1217737006068 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1217737006069 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737006070 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737006071 active site 1217737006072 metal binding site [ion binding]; metal-binding site 1217737006073 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1217737006074 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1217737006075 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1217737006076 Zn binding site [ion binding]; other site 1217737006077 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1217737006078 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1217737006079 DHHA2 domain; Region: DHHA2; pfam02833 1217737006080 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1217737006081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737006082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006083 Coenzyme A binding pocket [chemical binding]; other site 1217737006084 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737006085 Zn2+ binding site [ion binding]; other site 1217737006086 Mg2+ binding site [ion binding]; other site 1217737006087 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1217737006088 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737006089 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1217737006090 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1217737006091 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1217737006092 NAD(P) binding site [chemical binding]; other site 1217737006093 catalytic residues [active] 1217737006094 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1217737006095 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1217737006096 inhibitor site; inhibition site 1217737006097 active site 1217737006098 dimer interface [polypeptide binding]; other site 1217737006099 catalytic residue [active] 1217737006100 Proline racemase; Region: Pro_racemase; pfam05544 1217737006101 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1217737006102 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1217737006103 Proline racemase; Region: Pro_racemase; pfam05544 1217737006104 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1217737006105 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1217737006106 PAS domain; Region: PAS_10; pfam13596 1217737006107 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1217737006108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737006109 Walker A motif; other site 1217737006110 ATP binding site [chemical binding]; other site 1217737006111 Walker B motif; other site 1217737006112 arginine finger; other site 1217737006113 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1217737006114 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1217737006115 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1217737006116 catalytic loop [active] 1217737006117 iron binding site [ion binding]; other site 1217737006118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1217737006119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737006120 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 1217737006121 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1217737006122 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1217737006123 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737006124 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737006125 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1217737006126 DltD N-terminal region; Region: DltD_N; pfam04915 1217737006127 DltD central region; Region: DltD_M; pfam04918 1217737006128 DltD C-terminal region; Region: DltD_C; pfam04914 1217737006129 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737006130 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737006131 peptide binding site [polypeptide binding]; other site 1217737006132 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1217737006133 NlpC/P60 family; Region: NLPC_P60; pfam00877 1217737006134 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1217737006135 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1217737006136 active site 1217737006137 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 1217737006138 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1217737006139 Septum formation initiator; Region: DivIC; pfam04977 1217737006140 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737006141 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737006142 active site 1217737006143 catalytic tetrad [active] 1217737006144 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1217737006145 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1217737006146 conserved cys residue [active] 1217737006147 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1217737006148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1217737006149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1217737006150 AAA domain; Region: AAA_17; pfam13207 1217737006151 AAA domain; Region: AAA_18; pfam13238 1217737006152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737006153 S-adenosylmethionine binding site [chemical binding]; other site 1217737006154 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1217737006155 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1217737006156 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1217737006157 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1217737006158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737006159 dimerization interface [polypeptide binding]; other site 1217737006160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737006161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737006162 dimer interface [polypeptide binding]; other site 1217737006163 phosphorylation site [posttranslational modification] 1217737006164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737006165 ATP binding site [chemical binding]; other site 1217737006166 Mg2+ binding site [ion binding]; other site 1217737006167 G-X-G motif; other site 1217737006168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737006169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737006170 active site 1217737006171 phosphorylation site [posttranslational modification] 1217737006172 intermolecular recognition site; other site 1217737006173 dimerization interface [polypeptide binding]; other site 1217737006174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737006175 DNA binding site [nucleotide binding] 1217737006176 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 1217737006177 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 1217737006178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737006179 motif II; other site 1217737006180 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1217737006181 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1217737006182 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1217737006183 Zn binding site [ion binding]; other site 1217737006184 EDD domain protein, DegV family; Region: DegV; TIGR00762 1217737006185 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1217737006186 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1217737006187 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1217737006188 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1217737006189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1217737006190 Coenzyme A binding pocket [chemical binding]; other site 1217737006191 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1217737006192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737006194 putative substrate translocation pore; other site 1217737006195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006196 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1217737006197 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1217737006198 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1217737006199 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1217737006200 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1217737006201 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1217737006202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737006204 putative substrate translocation pore; other site 1217737006205 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1217737006206 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1217737006207 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1217737006208 active site 1217737006209 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1217737006210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737006211 S-adenosylmethionine binding site [chemical binding]; other site 1217737006212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006213 putative substrate translocation pore; other site 1217737006214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737006215 aspartate aminotransferase; Provisional; Region: PRK07681 1217737006216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737006217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737006218 homodimer interface [polypeptide binding]; other site 1217737006219 catalytic residue [active] 1217737006220 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1217737006221 pantothenate kinase; Provisional; Region: PRK13317 1217737006222 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1217737006223 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1217737006224 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1217737006225 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1217737006226 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1217737006227 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 1217737006228 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1217737006229 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1217737006230 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1217737006231 HNH endonuclease; Region: HNH_5; pfam14279 1217737006232 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1217737006233 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1217737006234 active site 1217737006235 dimer interface [polypeptide binding]; other site 1217737006236 non-prolyl cis peptide bond; other site 1217737006237 insertion regions; other site 1217737006238 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1217737006239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1217737006240 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1217737006241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737006242 substrate binding pocket [chemical binding]; other site 1217737006243 membrane-bound complex binding site; other site 1217737006244 hinge residues; other site 1217737006245 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1217737006246 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1217737006247 Walker A/P-loop; other site 1217737006248 ATP binding site [chemical binding]; other site 1217737006249 Q-loop/lid; other site 1217737006250 ABC transporter signature motif; other site 1217737006251 Walker B; other site 1217737006252 D-loop; other site 1217737006253 H-loop/switch region; other site 1217737006254 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1217737006255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1217737006256 binding surface 1217737006257 TPR motif; other site 1217737006258 hypothetical protein; Provisional; Region: PRK09620 1217737006259 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1217737006260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1217737006261 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737006262 Coenzyme A binding pocket [chemical binding]; other site 1217737006263 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1217737006264 DinB superfamily; Region: DinB_2; pfam12867 1217737006265 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1217737006266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1217737006267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006268 Coenzyme A binding pocket [chemical binding]; other site 1217737006269 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737006270 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737006271 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1217737006272 active site 1217737006273 NTP binding site [chemical binding]; other site 1217737006274 metal binding triad [ion binding]; metal-binding site 1217737006275 antibiotic binding site [chemical binding]; other site 1217737006276 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1217737006277 active site 1217737006278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1217737006279 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1217737006280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737006281 catalytic residue [active] 1217737006282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737006283 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737006284 active site 1217737006285 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737006286 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737006287 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1217737006288 NodB motif; other site 1217737006289 active site 1217737006290 catalytic site [active] 1217737006291 Zn binding site [ion binding]; other site 1217737006292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737006293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737006294 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1217737006295 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1217737006296 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1217737006297 Sulfatase; Region: Sulfatase; pfam00884 1217737006298 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1217737006299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737006300 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737006301 ABC transporter; Region: ABC_tran_2; pfam12848 1217737006302 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737006303 MMPL family; Region: MMPL; pfam03176 1217737006304 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1217737006305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737006306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737006307 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1217737006308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006309 Coenzyme A binding pocket [chemical binding]; other site 1217737006310 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1217737006311 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1217737006312 hinge; other site 1217737006313 active site 1217737006314 prephenate dehydrogenase; Validated; Region: PRK06545 1217737006315 prephenate dehydrogenase; Validated; Region: PRK08507 1217737006316 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1217737006317 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1217737006318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737006319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737006320 homodimer interface [polypeptide binding]; other site 1217737006321 catalytic residue [active] 1217737006322 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1217737006323 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1217737006324 Tetramer interface [polypeptide binding]; other site 1217737006325 active site 1217737006326 FMN-binding site [chemical binding]; other site 1217737006327 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1217737006328 Chorismate mutase type II; Region: CM_2; cl00693 1217737006329 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1217737006330 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 1217737006331 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 1217737006332 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1217737006333 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1217737006334 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737006335 catalytic triad [active] 1217737006336 conserved cis-peptide bond; other site 1217737006337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737006338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006339 Coenzyme A binding pocket [chemical binding]; other site 1217737006340 YfzA-like protein; Region: YfzA; pfam14118 1217737006341 hypothetical protein; Provisional; Region: PRK06762 1217737006342 AAA domain; Region: AAA_33; pfam13671 1217737006343 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737006344 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737006345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1217737006346 malate:quinone oxidoreductase; Validated; Region: PRK05257 1217737006347 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1217737006348 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1217737006349 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1217737006350 ligand binding site [chemical binding]; other site 1217737006351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1217737006352 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1217737006353 TM-ABC transporter signature motif; other site 1217737006354 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1217737006355 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1217737006356 TM-ABC transporter signature motif; other site 1217737006357 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1217737006358 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1217737006359 Walker A/P-loop; other site 1217737006360 ATP binding site [chemical binding]; other site 1217737006361 Q-loop/lid; other site 1217737006362 ABC transporter signature motif; other site 1217737006363 Walker B; other site 1217737006364 D-loop; other site 1217737006365 H-loop/switch region; other site 1217737006366 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1217737006367 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1217737006368 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1217737006369 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1217737006370 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1217737006371 putative N- and C-terminal domain interface [polypeptide binding]; other site 1217737006372 putative active site [active] 1217737006373 putative MgATP binding site [chemical binding]; other site 1217737006374 catalytic site [active] 1217737006375 metal binding site [ion binding]; metal-binding site 1217737006376 putative carbohydrate binding site [chemical binding]; other site 1217737006377 Cupin domain; Region: Cupin_2; pfam07883 1217737006378 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1217737006379 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1217737006380 putative active site; other site 1217737006381 catalytic residue [active] 1217737006382 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737006383 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737006384 active site 1217737006385 metal binding site [ion binding]; metal-binding site 1217737006386 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1217737006387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006388 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737006389 putative substrate translocation pore; other site 1217737006390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737006391 putative DNA binding site [nucleotide binding]; other site 1217737006392 putative Zn2+ binding site [ion binding]; other site 1217737006393 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737006394 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737006395 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737006396 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1217737006397 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1217737006398 putative catalytic cysteine [active] 1217737006399 gamma-glutamyl kinase; Provisional; Region: PRK05429 1217737006400 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1217737006401 nucleotide binding site [chemical binding]; other site 1217737006402 homotetrameric interface [polypeptide binding]; other site 1217737006403 putative phosphate binding site [ion binding]; other site 1217737006404 putative allosteric binding site; other site 1217737006405 PUA domain; Region: PUA; pfam01472 1217737006406 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 1217737006407 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1217737006408 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1217737006409 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1217737006410 putative metal binding site [ion binding]; other site 1217737006411 putative dimer interface [polypeptide binding]; other site 1217737006412 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1217737006413 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1217737006414 Bacterial transcriptional regulator; Region: IclR; pfam01614 1217737006415 S-methylmethionine transporter; Provisional; Region: PRK11387 1217737006416 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737006417 active site 1217737006418 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1217737006419 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1217737006420 putative di-iron ligands [ion binding]; other site 1217737006421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1217737006422 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1217737006423 VanW like protein; Region: VanW; pfam04294 1217737006424 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1217737006425 dimer interface [polypeptide binding]; other site 1217737006426 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1217737006427 active site 1217737006428 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1217737006429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737006430 salt bridge; other site 1217737006431 non-specific DNA binding site [nucleotide binding]; other site 1217737006432 sequence-specific DNA binding site [nucleotide binding]; other site 1217737006433 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1217737006434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737006435 motif II; other site 1217737006436 uridine kinase; Provisional; Region: PRK07667 1217737006437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737006438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737006440 Coenzyme A binding pocket [chemical binding]; other site 1217737006441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737006442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737006443 active site 1217737006444 metal binding site [ion binding]; metal-binding site 1217737006445 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1217737006446 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737006447 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1217737006448 MoxR-like ATPases [General function prediction only]; Region: COG0714 1217737006449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737006450 Walker A motif; other site 1217737006451 ATP binding site [chemical binding]; other site 1217737006452 Walker B motif; other site 1217737006453 arginine finger; other site 1217737006454 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1217737006455 Protein of unknown function DUF58; Region: DUF58; pfam01882 1217737006456 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 1217737006457 hypothetical protein; Provisional; Region: PRK06761 1217737006458 proline/glycine betaine transporter; Provisional; Region: PRK10642 1217737006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006460 putative substrate translocation pore; other site 1217737006461 acetylornithine aminotransferase; Provisional; Region: PRK02627 1217737006462 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737006463 inhibitor-cofactor binding pocket; inhibition site 1217737006464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737006465 catalytic residue [active] 1217737006466 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1217737006467 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1217737006468 tetramer interface [polypeptide binding]; other site 1217737006469 heme binding pocket [chemical binding]; other site 1217737006470 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1217737006471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1217737006472 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1217737006473 active site 1217737006474 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1217737006475 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737006476 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737006477 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1217737006478 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1217737006479 LXG domain of WXG superfamily; Region: LXG; pfam04740 1217737006480 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 1217737006481 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1217737006482 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1217737006483 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1217737006484 dimer interface [polypeptide binding]; other site 1217737006485 FMN binding site [chemical binding]; other site 1217737006486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737006487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737006488 putative DNA binding site [nucleotide binding]; other site 1217737006489 putative Zn2+ binding site [ion binding]; other site 1217737006490 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1217737006491 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1217737006492 G1 box; other site 1217737006493 putative GEF interaction site [polypeptide binding]; other site 1217737006494 GTP/Mg2+ binding site [chemical binding]; other site 1217737006495 Switch I region; other site 1217737006496 G2 box; other site 1217737006497 G3 box; other site 1217737006498 Switch II region; other site 1217737006499 G4 box; other site 1217737006500 G5 box; other site 1217737006501 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1217737006502 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1217737006503 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1217737006504 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1217737006505 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1217737006506 nudix motif; other site 1217737006507 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1217737006508 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1217737006509 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1217737006510 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1217737006511 putative NAD(P) binding site [chemical binding]; other site 1217737006512 active site 1217737006513 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737006514 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737006515 Walker A/P-loop; other site 1217737006516 ATP binding site [chemical binding]; other site 1217737006517 Q-loop/lid; other site 1217737006518 ABC transporter signature motif; other site 1217737006519 Walker B; other site 1217737006520 D-loop; other site 1217737006521 H-loop/switch region; other site 1217737006522 potential frameshift: common BLAST hit: gi|218898108|ref|YP_002446519.1| ABC transporter permease 1217737006523 FtsX-like permease family; Region: FtsX; pfam02687 1217737006524 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737006525 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737006526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1217737006527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737006528 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1217737006529 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1217737006530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006531 Coenzyme A binding pocket [chemical binding]; other site 1217737006532 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 1217737006533 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1217737006534 nudix motif; other site 1217737006535 EamA-like transporter family; Region: EamA; pfam00892 1217737006536 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737006537 EamA-like transporter family; Region: EamA; pfam00892 1217737006538 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737006539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737006540 DNA-binding site [nucleotide binding]; DNA binding site 1217737006541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737006542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737006543 homodimer interface [polypeptide binding]; other site 1217737006544 catalytic residue [active] 1217737006545 hypothetical protein; Validated; Region: PRK00124 1217737006546 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1217737006547 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1217737006548 uridine kinase; Validated; Region: PRK06696 1217737006549 AAA domain; Region: AAA_18; pfam13238 1217737006550 active site 1217737006551 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1217737006552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737006553 active site 1217737006554 metal binding site [ion binding]; metal-binding site 1217737006555 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737006556 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737006557 active site 1217737006558 substrate binding site [chemical binding]; other site 1217737006559 ATP binding site [chemical binding]; other site 1217737006560 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1217737006561 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1217737006562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737006563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737006564 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737006565 lysine transporter; Provisional; Region: PRK10836 1217737006566 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1217737006567 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1217737006568 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1217737006569 Cytochrome P450; Region: p450; cl12078 1217737006570 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1217737006571 active site 1217737006572 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1217737006573 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1217737006574 Transcription factor Tfb2; Region: Tfb2; cl04289 1217737006575 potential frameshift: common BLAST hit: gi|218898143|ref|YP_002446554.1| acyl-ACP desaturase 1217737006576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1217737006577 ATP binding site [chemical binding]; other site 1217737006578 G-X-G motif; other site 1217737006579 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1217737006580 S-adenosylmethionine binding site [chemical binding]; other site 1217737006581 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1217737006582 putative active site [active] 1217737006583 nucleotide binding site [chemical binding]; other site 1217737006584 nudix motif; other site 1217737006585 putative metal binding site [ion binding]; other site 1217737006586 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1217737006587 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1217737006588 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737006589 Catalytic site [active] 1217737006590 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737006591 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737006592 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737006593 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737006594 NAD-dependent deacetylase; Provisional; Region: PRK00481 1217737006595 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 1217737006596 NAD+ binding site [chemical binding]; other site 1217737006597 substrate binding site [chemical binding]; other site 1217737006598 Zn binding site [ion binding]; other site 1217737006599 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1217737006600 putative substrate binding pocket [chemical binding]; other site 1217737006601 AC domain interface; other site 1217737006602 catalytic triad [active] 1217737006603 AB domain interface; other site 1217737006604 interchain disulfide; other site 1217737006605 Predicted membrane protein [Function unknown]; Region: COG3817 1217737006606 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1217737006607 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1217737006608 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1217737006609 putative active site [active] 1217737006610 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1217737006611 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1217737006612 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1217737006613 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1217737006614 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1217737006615 Bacterial transcriptional regulator; Region: IclR; pfam01614 1217737006616 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1217737006617 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737006618 Catalytic site [active] 1217737006619 CutC family; Region: CutC; cl01218 1217737006620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737006621 dimerization interface [polypeptide binding]; other site 1217737006622 putative DNA binding site [nucleotide binding]; other site 1217737006623 putative Zn2+ binding site [ion binding]; other site 1217737006624 DinB superfamily; Region: DinB_2; pfam12867 1217737006625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1217737006626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1217737006627 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1217737006628 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1217737006629 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1217737006630 putative active site [active] 1217737006631 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737006632 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737006633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1217737006634 Nucleoside recognition; Region: Gate; pfam07670 1217737006635 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1217737006636 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737006637 putative active site [active] 1217737006638 putative substrate binding site [chemical binding]; other site 1217737006639 ATP binding site [chemical binding]; other site 1217737006640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006641 Coenzyme A binding pocket [chemical binding]; other site 1217737006642 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1217737006643 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1217737006644 dinuclear metal binding motif [ion binding]; other site 1217737006645 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 1217737006646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737006647 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737006648 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1217737006649 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1217737006650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737006651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737006652 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1217737006653 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1217737006654 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1217737006655 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1217737006656 YolD-like protein; Region: YolD; pfam08863 1217737006657 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737006658 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1217737006659 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1217737006660 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737006661 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1217737006662 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1217737006663 NAD binding site [chemical binding]; other site 1217737006664 catalytic Zn binding site [ion binding]; other site 1217737006665 structural Zn binding site [ion binding]; other site 1217737006666 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1217737006667 dimanganese center [ion binding]; other site 1217737006668 aspartate ammonia-lyase; Provisional; Region: PRK14515 1217737006669 Aspartase; Region: Aspartase; cd01357 1217737006670 active sites [active] 1217737006671 tetramer interface [polypeptide binding]; other site 1217737006672 potential frameshift: common BLAST hit: gi|218898184|ref|YP_002446595.1| L-asparaginase 1217737006673 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737006674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737006675 non-specific DNA binding site [nucleotide binding]; other site 1217737006676 salt bridge; other site 1217737006677 sequence-specific DNA binding site [nucleotide binding]; other site 1217737006678 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1217737006679 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737006680 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737006681 Spore germination protein; Region: Spore_permease; pfam03845 1217737006682 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737006683 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1217737006684 PAS fold; Region: PAS_4; pfam08448 1217737006685 PAS domain S-box; Region: sensory_box; TIGR00229 1217737006686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737006687 putative active site [active] 1217737006688 heme pocket [chemical binding]; other site 1217737006689 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1217737006690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737006691 putative active site [active] 1217737006692 heme pocket [chemical binding]; other site 1217737006693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737006694 dimer interface [polypeptide binding]; other site 1217737006695 phosphorylation site [posttranslational modification] 1217737006696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737006697 ATP binding site [chemical binding]; other site 1217737006698 Mg2+ binding site [ion binding]; other site 1217737006699 G-X-G motif; other site 1217737006700 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737006701 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737006702 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737006703 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1217737006704 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 1217737006705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737006706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737006707 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737006708 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1217737006709 GIY-YIG motif/motif A; other site 1217737006710 active site 1217737006711 catalytic site [active] 1217737006712 putative DNA binding site [nucleotide binding]; other site 1217737006713 metal binding site [ion binding]; metal-binding site 1217737006714 amino acid transporter; Region: 2A0306; TIGR00909 1217737006715 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1217737006716 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 1217737006717 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1217737006718 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737006719 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737006720 Spore germination protein; Region: Spore_permease; pfam03845 1217737006721 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737006722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737006723 Response regulator receiver domain; Region: Response_reg; pfam00072 1217737006724 active site 1217737006725 phosphorylation site [posttranslational modification] 1217737006726 intermolecular recognition site; other site 1217737006727 dimerization interface [polypeptide binding]; other site 1217737006728 YcbB domain; Region: YcbB; pfam08664 1217737006729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737006730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737006731 ATP binding site [chemical binding]; other site 1217737006732 Mg2+ binding site [ion binding]; other site 1217737006733 G-X-G motif; other site 1217737006734 glutaminase; Reviewed; Region: PRK12357 1217737006735 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1217737006736 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737006737 amino acid carrier protein; Region: agcS; TIGR00835 1217737006738 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1217737006739 transmembrane helices; other site 1217737006740 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1217737006741 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737006742 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737006743 Erythromycin esterase; Region: Erythro_esteras; cl17110 1217737006744 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1217737006745 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1217737006746 putative active site [active] 1217737006747 putative metal binding site [ion binding]; other site 1217737006748 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1217737006749 potential frameshift: common BLAST hit: gi|218898215|ref|YP_002446626.1| bromoperoxidase 1217737006750 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737006751 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1217737006752 catalytic triad [active] 1217737006753 dimer interface [polypeptide binding]; other site 1217737006754 conserved cis-peptide bond; other site 1217737006755 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737006756 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1217737006757 catalytic triad [active] 1217737006758 dimer interface [polypeptide binding]; other site 1217737006759 conserved cis-peptide bond; other site 1217737006760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1217737006761 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1217737006762 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1217737006763 active site 1217737006764 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1217737006765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737006766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737006767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737006768 dimerization interface [polypeptide binding]; other site 1217737006769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737006770 MarR family; Region: MarR; pfam01047 1217737006771 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1217737006772 Cl binding site [ion binding]; other site 1217737006773 oligomer interface [polypeptide binding]; other site 1217737006774 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1217737006775 plasmid segregation protein ParM; Provisional; Region: PRK13917 1217737006776 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1217737006777 Mg binding site [ion binding]; other site 1217737006778 nucleotide binding site [chemical binding]; other site 1217737006779 putative protofilament interface [polypeptide binding]; other site 1217737006780 Heat induced stress protein YflT; Region: YflT; pfam11181 1217737006781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737006782 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737006783 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737006784 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1217737006785 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1217737006786 TspO/MBR family; Region: TspO_MBR; pfam03073 1217737006787 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1217737006788 DNA photolyase; Region: DNA_photolyase; pfam00875 1217737006789 Carbonic anhydrase; Region: Pro_CA; pfam00484 1217737006790 zinc binding site [ion binding]; other site 1217737006791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1217737006792 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1217737006793 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1217737006794 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1217737006795 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1217737006796 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737006797 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1217737006798 NodB motif; other site 1217737006799 active site 1217737006800 catalytic site [active] 1217737006801 Zn binding site [ion binding]; other site 1217737006802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737006803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737006804 Coenzyme A binding pocket [chemical binding]; other site 1217737006805 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1217737006806 UbiA prenyltransferase family; Region: UbiA; pfam01040 1217737006807 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1217737006808 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1217737006809 metal binding site [ion binding]; metal-binding site 1217737006810 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1217737006811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737006812 ABC-ATPase subunit interface; other site 1217737006813 dimer interface [polypeptide binding]; other site 1217737006814 putative PBP binding regions; other site 1217737006815 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1217737006816 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1217737006817 DJ-1 family protein; Region: not_thiJ; TIGR01383 1217737006818 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1217737006819 conserved cys residue [active] 1217737006820 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1217737006821 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1217737006822 active site 1217737006823 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1217737006824 arsenical-resistance protein; Region: acr3; TIGR00832 1217737006825 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737006826 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1217737006827 putative metal binding site [ion binding]; other site 1217737006828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737006829 dimerization interface [polypeptide binding]; other site 1217737006830 putative DNA binding site [nucleotide binding]; other site 1217737006831 putative Zn2+ binding site [ion binding]; other site 1217737006832 Putative amidotransferase; Region: DUF4066; pfam13278 1217737006833 conserved cys residue [active] 1217737006834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737006835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737006836 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1217737006837 putative dimerization interface [polypeptide binding]; other site 1217737006838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006839 putative substrate translocation pore; other site 1217737006840 D-galactonate transporter; Region: 2A0114; TIGR00893 1217737006841 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737006842 EamA-like transporter family; Region: EamA; pfam00892 1217737006843 EamA-like transporter family; Region: EamA; pfam00892 1217737006844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737006845 active site 1217737006846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737006847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737006848 DinB superfamily; Region: DinB_2; pfam12867 1217737006849 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1217737006850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737006851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737006852 non-specific DNA binding site [nucleotide binding]; other site 1217737006853 salt bridge; other site 1217737006854 sequence-specific DNA binding site [nucleotide binding]; other site 1217737006855 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737006856 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1217737006857 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1217737006858 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737006859 MarR family; Region: MarR_2; pfam12802 1217737006860 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1217737006861 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1217737006862 putative NAD(P) binding site [chemical binding]; other site 1217737006863 active site 1217737006864 putative substrate binding site [chemical binding]; other site 1217737006865 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737006866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737006867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737006868 short chain dehydrogenase; Provisional; Region: PRK12746 1217737006869 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1217737006870 NADP binding site [chemical binding]; other site 1217737006871 homodimer interface [polypeptide binding]; other site 1217737006872 active site 1217737006873 substrate binding site [chemical binding]; other site 1217737006874 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1217737006875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737006876 putative DNA binding site [nucleotide binding]; other site 1217737006877 putative Zn2+ binding site [ion binding]; other site 1217737006878 AsnC family; Region: AsnC_trans_reg; pfam01037 1217737006879 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1217737006880 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1217737006881 metal binding site [ion binding]; metal-binding site 1217737006882 AAA domain; Region: AAA_11; pfam13086 1217737006883 Part of AAA domain; Region: AAA_19; pfam13245 1217737006884 Erp protein C-terminus; Region: Erp_C; pfam06780 1217737006885 AAA domain; Region: AAA_30; pfam13604 1217737006886 AAA domain; Region: AAA_12; pfam13087 1217737006887 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1217737006888 putative active site [active] 1217737006889 catalytic site [active] 1217737006890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737006891 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737006892 active site 1217737006893 metal binding site [ion binding]; metal-binding site 1217737006894 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737006895 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737006896 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1217737006897 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1217737006898 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 1217737006899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737006900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737006901 active site 1217737006902 phosphorylation site [posttranslational modification] 1217737006903 intermolecular recognition site; other site 1217737006904 dimerization interface [polypeptide binding]; other site 1217737006905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737006906 DNA binding site [nucleotide binding] 1217737006907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737006908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737006909 dimerization interface [polypeptide binding]; other site 1217737006910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737006911 dimer interface [polypeptide binding]; other site 1217737006912 phosphorylation site [posttranslational modification] 1217737006913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737006914 ATP binding site [chemical binding]; other site 1217737006915 G-X-G motif; other site 1217737006916 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1217737006917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1217737006918 CAAX protease self-immunity; Region: Abi; pfam02517 1217737006919 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1217737006920 Putative sensor; Region: Sensor; pfam13796 1217737006921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1217737006922 Histidine kinase; Region: HisKA_3; pfam07730 1217737006923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737006924 ATP binding site [chemical binding]; other site 1217737006925 Mg2+ binding site [ion binding]; other site 1217737006926 G-X-G motif; other site 1217737006927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737006928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737006929 active site 1217737006930 phosphorylation site [posttranslational modification] 1217737006931 intermolecular recognition site; other site 1217737006932 dimerization interface [polypeptide binding]; other site 1217737006933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737006934 DNA binding residues [nucleotide binding] 1217737006935 dimerization interface [polypeptide binding]; other site 1217737006936 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1217737006937 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737006938 Berberine and berberine like; Region: BBE; pfam08031 1217737006939 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737006940 FtsX-like permease family; Region: FtsX; pfam02687 1217737006941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737006942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737006943 Walker A/P-loop; other site 1217737006944 ATP binding site [chemical binding]; other site 1217737006945 Q-loop/lid; other site 1217737006946 ABC transporter signature motif; other site 1217737006947 Walker B; other site 1217737006948 D-loop; other site 1217737006949 H-loop/switch region; other site 1217737006950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737006951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737006952 dimer interface [polypeptide binding]; other site 1217737006953 phosphorylation site [posttranslational modification] 1217737006954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737006955 ATP binding site [chemical binding]; other site 1217737006956 Mg2+ binding site [ion binding]; other site 1217737006957 G-X-G motif; other site 1217737006958 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737006959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737006960 active site 1217737006961 phosphorylation site [posttranslational modification] 1217737006962 intermolecular recognition site; other site 1217737006963 dimerization interface [polypeptide binding]; other site 1217737006964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737006965 DNA binding site [nucleotide binding] 1217737006966 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1217737006967 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1217737006968 putative metal binding site [ion binding]; other site 1217737006969 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1217737006970 Cytochrome P450; Region: p450; pfam00067 1217737006971 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1217737006972 Flavodoxin; Region: Flavodoxin_1; pfam00258 1217737006973 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1217737006974 FAD binding pocket [chemical binding]; other site 1217737006975 FAD binding motif [chemical binding]; other site 1217737006976 catalytic residues [active] 1217737006977 NAD binding pocket [chemical binding]; other site 1217737006978 phosphate binding motif [ion binding]; other site 1217737006979 beta-alpha-beta structure motif; other site 1217737006980 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1217737006981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006982 putative substrate translocation pore; other site 1217737006983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737006984 D-cysteine desulfhydrase; Validated; Region: PRK03910 1217737006985 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1217737006986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737006987 catalytic residue [active] 1217737006988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737006989 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1217737006990 active site 1217737006991 metal binding site [ion binding]; metal-binding site 1217737006992 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1217737006993 Protein of unknown function (DUF975); Region: DUF975; cl10504 1217737006994 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1217737006995 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1217737006996 AAA domain; Region: AAA_33; pfam13671 1217737006997 AAA domain; Region: AAA_17; pfam13207 1217737006998 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 1217737006999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737007000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737007001 Walker A/P-loop; other site 1217737007002 ATP binding site [chemical binding]; other site 1217737007003 Q-loop/lid; other site 1217737007004 ABC transporter signature motif; other site 1217737007005 Walker B; other site 1217737007006 D-loop; other site 1217737007007 H-loop/switch region; other site 1217737007008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1217737007009 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737007010 FtsX-like permease family; Region: FtsX; pfam02687 1217737007011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737007012 dimerization interface [polypeptide binding]; other site 1217737007013 putative DNA binding site [nucleotide binding]; other site 1217737007014 Predicted transcriptional regulator [Transcription]; Region: COG2345 1217737007015 putative Zn2+ binding site [ion binding]; other site 1217737007016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007017 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737007018 putative substrate translocation pore; other site 1217737007019 DinB superfamily; Region: DinB_2; pfam12867 1217737007020 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1217737007021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737007022 dimerization interface [polypeptide binding]; other site 1217737007023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737007024 dimer interface [polypeptide binding]; other site 1217737007025 phosphorylation site [posttranslational modification] 1217737007026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737007027 ATP binding site [chemical binding]; other site 1217737007028 Mg2+ binding site [ion binding]; other site 1217737007029 G-X-G motif; other site 1217737007030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737007031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737007032 active site 1217737007033 phosphorylation site [posttranslational modification] 1217737007034 intermolecular recognition site; other site 1217737007035 dimerization interface [polypeptide binding]; other site 1217737007036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737007037 DNA binding site [nucleotide binding] 1217737007038 Predicted membrane protein [Function unknown]; Region: COG2364 1217737007039 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1217737007040 MarR family; Region: MarR; pfam01047 1217737007041 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1217737007042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737007043 Coenzyme A binding pocket [chemical binding]; other site 1217737007044 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1217737007045 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737007046 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737007047 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737007048 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 1217737007049 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1217737007050 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1217737007051 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1217737007052 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1217737007053 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1217737007054 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1217737007055 putative ligand binding site [chemical binding]; other site 1217737007056 putative NAD binding site [chemical binding]; other site 1217737007057 putative catalytic site [active] 1217737007058 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1217737007059 L-serine binding site [chemical binding]; other site 1217737007060 ACT domain interface; other site 1217737007061 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1217737007062 homodimer interface [polypeptide binding]; other site 1217737007063 substrate-cofactor binding pocket; other site 1217737007064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737007065 catalytic residue [active] 1217737007066 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1217737007067 Cupin domain; Region: Cupin_2; cl17218 1217737007068 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1217737007069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737007070 Penicillin amidase; Region: Penicil_amidase; pfam01804 1217737007071 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1217737007072 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1217737007073 active site 1217737007074 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1217737007075 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737007076 substrate binding site [chemical binding]; other site 1217737007077 amidase catalytic site [active] 1217737007078 Zn binding residues [ion binding]; other site 1217737007079 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737007080 S-layer homology domain; Region: SLH; pfam00395 1217737007081 S-layer homology domain; Region: SLH; pfam00395 1217737007082 S-layer homology domain; Region: SLH; pfam00395 1217737007083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737007084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737007085 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1217737007086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007087 putative substrate translocation pore; other site 1217737007088 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1217737007089 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1217737007090 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1217737007091 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1217737007092 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1217737007093 active site 1217737007094 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1217737007095 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 1217737007096 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1217737007097 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737007098 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737007099 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1217737007100 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1217737007101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1217737007102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1217737007103 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737007104 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1217737007105 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1217737007106 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1217737007107 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1217737007108 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1217737007109 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1217737007110 putative active site [active] 1217737007111 putative metal binding site [ion binding]; other site 1217737007112 NETI protein; Region: NETI; pfam14044 1217737007113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737007115 putative substrate translocation pore; other site 1217737007116 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737007117 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737007118 TAP-like protein; Region: Abhydrolase_4; pfam08386 1217737007119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737007120 MarR family; Region: MarR_2; pfam12802 1217737007121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737007122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007123 putative substrate translocation pore; other site 1217737007124 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737007125 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737007126 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1217737007127 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1217737007128 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1217737007129 SWIM zinc finger; Region: SWIM; pfam04434 1217737007130 YwiC-like protein; Region: YwiC; pfam14256 1217737007131 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1217737007132 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737007133 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1217737007134 Walker A/P-loop; other site 1217737007135 ATP binding site [chemical binding]; other site 1217737007136 Q-loop/lid; other site 1217737007137 ABC transporter signature motif; other site 1217737007138 Walker B; other site 1217737007139 D-loop; other site 1217737007140 H-loop/switch region; other site 1217737007141 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737007142 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 1217737007143 Walker A/P-loop; other site 1217737007144 ATP binding site [chemical binding]; other site 1217737007145 Q-loop/lid; other site 1217737007146 ABC transporter signature motif; other site 1217737007147 Walker B; other site 1217737007148 D-loop; other site 1217737007149 H-loop/switch region; other site 1217737007150 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1217737007151 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1217737007152 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1217737007153 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1217737007154 Predicted membrane protein [Function unknown]; Region: COG1288 1217737007155 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1217737007156 Endonuclease I; Region: Endonuclease_1; pfam04231 1217737007157 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1217737007158 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1217737007159 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1217737007160 putative deacylase active site [active] 1217737007161 histidyl-tRNA synthetase; Provisional; Region: PRK12420 1217737007162 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1217737007163 dimer interface [polypeptide binding]; other site 1217737007164 motif 1; other site 1217737007165 active site 1217737007166 motif 2; other site 1217737007167 motif 3; other site 1217737007168 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1217737007169 anticodon binding site; other site 1217737007170 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737007171 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1217737007172 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1217737007173 dimer interface [polypeptide binding]; other site 1217737007174 FMN binding site [chemical binding]; other site 1217737007175 pyruvate kinase; Validated; Region: PRK06739 1217737007176 active site 1217737007177 domain interfaces; other site 1217737007178 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1217737007179 classical (c) SDRs; Region: SDR_c; cd05233 1217737007180 NAD(P) binding site [chemical binding]; other site 1217737007181 active site 1217737007182 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1217737007183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737007184 Walker A/P-loop; other site 1217737007185 ATP binding site [chemical binding]; other site 1217737007186 Q-loop/lid; other site 1217737007187 ABC transporter signature motif; other site 1217737007188 Walker B; other site 1217737007189 D-loop; other site 1217737007190 H-loop/switch region; other site 1217737007191 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 1217737007192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007193 non-specific DNA binding site [nucleotide binding]; other site 1217737007194 salt bridge; other site 1217737007195 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007196 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1217737007197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737007198 motif II; other site 1217737007199 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1217737007200 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1217737007201 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1217737007202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737007203 Coenzyme A binding pocket [chemical binding]; other site 1217737007204 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1217737007205 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1217737007206 nudix motif; other site 1217737007207 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1217737007208 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1217737007209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737007210 putative metal binding site [ion binding]; other site 1217737007211 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1217737007212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1217737007213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737007215 putative substrate translocation pore; other site 1217737007216 maltose O-acetyltransferase; Provisional; Region: PRK10092 1217737007217 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1217737007218 active site 1217737007219 substrate binding site [chemical binding]; other site 1217737007220 trimer interface [polypeptide binding]; other site 1217737007221 CoA binding site [chemical binding]; other site 1217737007222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1217737007223 FtsX-like permease family; Region: FtsX; pfam02687 1217737007224 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1217737007225 FtsX-like permease family; Region: FtsX; pfam02687 1217737007226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737007227 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737007228 Walker A/P-loop; other site 1217737007229 ATP binding site [chemical binding]; other site 1217737007230 Q-loop/lid; other site 1217737007231 ABC transporter signature motif; other site 1217737007232 Walker B; other site 1217737007233 D-loop; other site 1217737007234 H-loop/switch region; other site 1217737007235 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1217737007236 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1217737007237 active site 1217737007238 HIGH motif; other site 1217737007239 dimer interface [polypeptide binding]; other site 1217737007240 KMSKS motif; other site 1217737007241 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 1217737007242 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1217737007243 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1217737007244 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1217737007245 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1217737007246 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1217737007247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737007248 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737007249 Coenzyme A binding pocket [chemical binding]; other site 1217737007250 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1217737007251 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1217737007252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1217737007253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737007254 S-adenosylmethionine binding site [chemical binding]; other site 1217737007255 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1217737007256 CGNR zinc finger; Region: zf-CGNR; pfam11706 1217737007257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737007259 putative substrate translocation pore; other site 1217737007260 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1217737007261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737007262 TPR motif; other site 1217737007263 binding surface 1217737007264 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1217737007265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737007266 binding surface 1217737007267 TPR motif; other site 1217737007268 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 1217737007269 hypothetical protein; Provisional; Region: PRK04164 1217737007270 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737007271 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1217737007272 Domain of unknown function DUF21; Region: DUF21; pfam01595 1217737007273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1217737007274 Transporter associated domain; Region: CorC_HlyC; smart01091 1217737007275 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1217737007276 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737007277 DNA binding residues [nucleotide binding] 1217737007278 putative dimer interface [polypeptide binding]; other site 1217737007279 EamA-like transporter family; Region: EamA; pfam00892 1217737007280 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737007281 EamA-like transporter family; Region: EamA; pfam00892 1217737007282 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1217737007283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1217737007284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1217737007285 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1217737007286 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1217737007287 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1217737007288 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1217737007289 N- and C-terminal domain interface [polypeptide binding]; other site 1217737007290 active site 1217737007291 catalytic site [active] 1217737007292 metal binding site [ion binding]; metal-binding site 1217737007293 carbohydrate binding site [chemical binding]; other site 1217737007294 ATP binding site [chemical binding]; other site 1217737007295 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1217737007296 active site 1217737007297 intersubunit interactions; other site 1217737007298 catalytic residue [active] 1217737007299 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1217737007300 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1217737007301 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1217737007302 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1217737007303 TPP-binding site [chemical binding]; other site 1217737007304 dimer interface [polypeptide binding]; other site 1217737007305 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1217737007306 PYR/PP interface [polypeptide binding]; other site 1217737007307 dimer interface [polypeptide binding]; other site 1217737007308 TPP binding site [chemical binding]; other site 1217737007309 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1217737007310 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1217737007311 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1217737007312 hypothetical protein; Provisional; Region: PRK02487 1217737007313 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1217737007314 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1217737007315 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1217737007316 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1217737007317 A short protein domain of unknown function; Region: IDEAL; smart00914 1217737007318 Transcriptional regulator; Region: Rrf2; pfam02082 1217737007319 Rrf2 family protein; Region: rrf2_super; TIGR00738 1217737007320 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1217737007321 ArsC family; Region: ArsC; pfam03960 1217737007322 putative catalytic residues [active] 1217737007323 thiol/disulfide switch; other site 1217737007324 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737007325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737007326 dimerization interface [polypeptide binding]; other site 1217737007327 putative DNA binding site [nucleotide binding]; other site 1217737007328 putative Zn2+ binding site [ion binding]; other site 1217737007329 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1217737007330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737007331 DNA-binding site [nucleotide binding]; DNA binding site 1217737007332 UTRA domain; Region: UTRA; pfam07702 1217737007333 putative oxidoreductase; Provisional; Region: PRK10206 1217737007334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1217737007335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1217737007336 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1217737007337 putative hydrophobic ligand binding site [chemical binding]; other site 1217737007338 protein interface [polypeptide binding]; other site 1217737007339 gate; other site 1217737007340 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1217737007341 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1217737007342 putative active site [active] 1217737007343 putative catalytic triad [active] 1217737007344 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1217737007345 catalytic triad [active] 1217737007346 oxyanion hole [active] 1217737007347 active site 1217737007348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737007349 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737007350 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737007351 active site 1217737007352 substrate binding site [chemical binding]; other site 1217737007353 ATP binding site [chemical binding]; other site 1217737007354 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1217737007355 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1217737007356 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1217737007357 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1217737007358 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737007359 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737007360 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1217737007361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1217737007362 acyl-activating enzyme (AAE) consensus motif; other site 1217737007363 AMP binding site [chemical binding]; other site 1217737007364 active site 1217737007365 CoA binding site [chemical binding]; other site 1217737007366 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1217737007367 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737007368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737007369 dimerization interface [polypeptide binding]; other site 1217737007370 putative DNA binding site [nucleotide binding]; other site 1217737007371 putative Zn2+ binding site [ion binding]; other site 1217737007372 hypothetical protein; Provisional; Region: PRK08244 1217737007373 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1217737007374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737007375 dimerization interface [polypeptide binding]; other site 1217737007376 putative DNA binding site [nucleotide binding]; other site 1217737007377 putative Zn2+ binding site [ion binding]; other site 1217737007378 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1217737007379 active site 1217737007380 Glyco_18 domain; Region: Glyco_18; smart00636 1217737007381 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1217737007382 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 1217737007383 NodB motif; other site 1217737007384 putative active site [active] 1217737007385 putative catalytic site [active] 1217737007386 putative Zn binding site [ion binding]; other site 1217737007387 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1217737007388 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1217737007389 DXD motif; other site 1217737007390 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1217737007391 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1217737007392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737007393 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 1217737007394 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1217737007395 HTH domain; Region: HTH_11; pfam08279 1217737007396 WYL domain; Region: WYL; pfam13280 1217737007397 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1217737007398 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1217737007399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737007400 Walker A/P-loop; other site 1217737007401 ATP binding site [chemical binding]; other site 1217737007402 Q-loop/lid; other site 1217737007403 ABC transporter signature motif; other site 1217737007404 Walker B; other site 1217737007405 D-loop; other site 1217737007406 H-loop/switch region; other site 1217737007407 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1217737007408 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737007409 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737007410 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1217737007411 hydroxylamine reductase; Provisional; Region: PRK12310 1217737007412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1217737007413 ACS interaction site; other site 1217737007414 CODH interaction site; other site 1217737007415 metal cluster binding site [ion binding]; other site 1217737007416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737007417 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 1217737007418 hypothetical protein; Provisional; Region: PRK06771 1217737007419 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737007420 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737007421 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1217737007422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1217737007423 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1217737007424 dimer interface [polypeptide binding]; other site 1217737007425 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737007426 ligand binding site [chemical binding]; other site 1217737007427 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1217737007428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1217737007429 ligand binding site [chemical binding]; other site 1217737007430 flexible hinge region; other site 1217737007431 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1217737007432 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1217737007433 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1217737007434 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737007435 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1217737007436 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1217737007437 putative NAD(P) binding site [chemical binding]; other site 1217737007438 dimer interface [polypeptide binding]; other site 1217737007439 putative transport protein YifK; Provisional; Region: PRK10746 1217737007440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737007441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737007442 putative substrate translocation pore; other site 1217737007443 Haemolysin XhlA; Region: XhlA; pfam10779 1217737007444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1217737007445 classical (c) SDRs; Region: SDR_c; cd05233 1217737007446 NAD(P) binding site [chemical binding]; other site 1217737007447 active site 1217737007448 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1217737007449 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1217737007450 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1217737007451 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1217737007452 transmembrane helices; other site 1217737007453 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737007454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737007455 Coenzyme A binding pocket [chemical binding]; other site 1217737007456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737007457 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1217737007458 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1217737007459 DinB superfamily; Region: DinB_2; pfam12867 1217737007460 DinB family; Region: DinB; cl17821 1217737007461 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1217737007462 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1217737007463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737007464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737007465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737007466 dimerization interface [polypeptide binding]; other site 1217737007467 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1217737007468 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1217737007469 NADP binding site [chemical binding]; other site 1217737007470 dimer interface [polypeptide binding]; other site 1217737007471 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737007472 catalytic core [active] 1217737007473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737007474 Coenzyme A binding pocket [chemical binding]; other site 1217737007475 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 1217737007476 MutS domain III; Region: MutS_III; pfam05192 1217737007477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737007478 Walker A/P-loop; other site 1217737007479 ATP binding site [chemical binding]; other site 1217737007480 Q-loop/lid; other site 1217737007481 ABC transporter signature motif; other site 1217737007482 Walker B; other site 1217737007483 D-loop; other site 1217737007484 H-loop/switch region; other site 1217737007485 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1217737007486 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1217737007487 active site 1217737007488 Na/Ca binding site [ion binding]; other site 1217737007489 catalytic site [active] 1217737007490 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1217737007491 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1217737007492 oligoendopeptidase F; Region: pepF; TIGR00181 1217737007493 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1217737007494 active site 1217737007495 Zn binding site [ion binding]; other site 1217737007496 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1217737007497 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1217737007498 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1217737007499 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737007500 DNA binding residues [nucleotide binding] 1217737007501 drug binding residues [chemical binding]; other site 1217737007502 dimer interface [polypeptide binding]; other site 1217737007503 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1217737007504 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1217737007505 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1217737007506 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1217737007507 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1217737007508 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737007509 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737007510 potential frameshift: common BLAST hit: gi|218898552|ref|YP_002446963.1| major facilitator family transporter 1217737007511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737007512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737007513 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1217737007514 putative dimerization interface [polypeptide binding]; other site 1217737007515 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 1217737007516 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1217737007517 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1217737007518 active site 1217737007519 catalytic site [active] 1217737007520 metal binding site [ion binding]; metal-binding site 1217737007521 FAD binding domain; Region: FAD_binding_3; pfam01494 1217737007522 hypothetical protein; Provisional; Region: PRK07236 1217737007523 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1217737007524 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737007525 dimerization interface [polypeptide binding]; other site 1217737007526 putative DNA binding site [nucleotide binding]; other site 1217737007527 putative Zn2+ binding site [ion binding]; other site 1217737007528 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1217737007529 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1217737007530 putative NAD(P) binding site [chemical binding]; other site 1217737007531 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1217737007532 hypothetical protein; Validated; Region: PRK00029 1217737007533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737007534 TPR motif; other site 1217737007535 binding surface 1217737007536 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1217737007537 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1217737007538 Sodium Bile acid symporter family; Region: SBF; cl17470 1217737007539 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1217737007540 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737007541 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1217737007542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737007543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737007544 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1217737007545 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737007546 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737007547 active site residue [active] 1217737007548 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1217737007549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737007550 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1217737007551 phosphate binding motif [ion binding]; other site 1217737007552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1217737007553 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1217737007554 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1217737007555 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1217737007556 potential frameshift: common BLAST hit: gi|375286165|ref|YP_005106604.1| cell division protein, FtsW/RodA/SpoVE family 1217737007557 pseudaminic acid synthase; Region: PseI; TIGR03586 1217737007558 NeuB family; Region: NeuB; pfam03102 1217737007559 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1217737007560 NeuB binding interface [polypeptide binding]; other site 1217737007561 putative substrate binding site [chemical binding]; other site 1217737007562 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1217737007563 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737007564 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1217737007565 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1217737007566 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1217737007567 ligand binding site; other site 1217737007568 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1217737007569 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1217737007570 inhibitor-cofactor binding pocket; inhibition site 1217737007571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737007572 catalytic residue [active] 1217737007573 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737007574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737007575 NAD(P) binding site [chemical binding]; other site 1217737007576 active site 1217737007577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737007578 NAD(P) binding site [chemical binding]; other site 1217737007579 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1217737007580 active site 1217737007581 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1217737007582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737007583 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1217737007584 active site 1217737007585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1217737007586 active site 1217737007587 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1217737007588 active site 1217737007589 catalytic site [active] 1217737007590 putative metal binding site [ion binding]; other site 1217737007591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1217737007592 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1217737007593 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1217737007594 Interdomain contacts; other site 1217737007595 Cytokine receptor motif; other site 1217737007596 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1217737007597 Interdomain contacts; other site 1217737007598 Cytokine receptor motif; other site 1217737007599 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1217737007600 Fic/DOC family; Region: Fic; pfam02661 1217737007601 Fic family protein [Function unknown]; Region: COG3177 1217737007602 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737007603 Spore germination protein; Region: Spore_permease; cl17796 1217737007604 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737007605 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737007606 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1217737007607 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1217737007608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1217737007609 active site 1217737007610 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737007611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737007612 NAD(P) binding site [chemical binding]; other site 1217737007613 active site 1217737007614 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1217737007615 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1217737007616 NAD binding site [chemical binding]; other site 1217737007617 homotetramer interface [polypeptide binding]; other site 1217737007618 homodimer interface [polypeptide binding]; other site 1217737007619 substrate binding site [chemical binding]; other site 1217737007620 active site 1217737007621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737007622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737007623 TPR motif; other site 1217737007624 binding surface 1217737007625 Tar ligand binding domain homologue; Region: TarH; pfam02203 1217737007626 Cache domain; Region: Cache_1; pfam02743 1217737007627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737007628 dimerization interface [polypeptide binding]; other site 1217737007629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737007630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737007631 dimer interface [polypeptide binding]; other site 1217737007632 putative CheW interface [polypeptide binding]; other site 1217737007633 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 1217737007634 PKC phosphorylation site [posttranslational modification]; other site 1217737007635 Peptidase M60-like family; Region: M60-like; pfam13402 1217737007636 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1217737007637 PAS domain S-box; Region: sensory_box; TIGR00229 1217737007638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737007639 putative active site [active] 1217737007640 heme pocket [chemical binding]; other site 1217737007641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737007642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737007643 metal binding site [ion binding]; metal-binding site 1217737007644 active site 1217737007645 I-site; other site 1217737007646 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737007647 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737007648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737007649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737007650 Walker A/P-loop; other site 1217737007651 ATP binding site [chemical binding]; other site 1217737007652 Q-loop/lid; other site 1217737007653 ABC transporter signature motif; other site 1217737007654 D-loop; other site 1217737007655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737007656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737007657 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1217737007658 Replication-relaxation; Region: Replic_Relax; pfam13814 1217737007659 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737007660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007661 non-specific DNA binding site [nucleotide binding]; other site 1217737007662 salt bridge; other site 1217737007663 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007664 hypothetical protein; Region: PHA02436 1217737007665 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737007666 amidase catalytic site [active] 1217737007667 Zn binding residues [ion binding]; other site 1217737007668 substrate binding site [chemical binding]; other site 1217737007669 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737007670 Holin family; Region: Phage_holin_4; pfam05105 1217737007671 Haemolysin XhlA; Region: XhlA; pfam10779 1217737007672 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1217737007673 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1217737007674 Phage tail protein; Region: Sipho_tail; pfam05709 1217737007675 Phage tail protein; Region: Sipho_tail; cl17486 1217737007676 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1217737007677 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1217737007678 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1217737007679 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1217737007680 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1217737007681 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1217737007682 oligomerization interface [polypeptide binding]; other site 1217737007683 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1217737007684 Phage capsid family; Region: Phage_capsid; pfam05065 1217737007685 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1217737007686 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1217737007687 oligomer interface [polypeptide binding]; other site 1217737007688 active site residues [active] 1217737007689 Phage portal protein; Region: Phage_portal; pfam04860 1217737007690 Phage-related protein [Function unknown]; Region: COG4695 1217737007691 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1217737007692 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1217737007693 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1217737007694 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1217737007695 active site 1217737007696 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1217737007697 Int/Topo IB signature motif; other site 1217737007698 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1217737007699 YopX protein; Region: YopX; pfam09643 1217737007700 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1217737007701 YjcQ protein; Region: YjcQ; pfam09639 1217737007702 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737007703 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1217737007704 hypothetical protein; Provisional; Region: PRK06921 1217737007705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1217737007706 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1217737007707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737007708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737007709 DNA binding residues [nucleotide binding] 1217737007710 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1217737007711 ORF6C domain; Region: ORF6C; pfam10552 1217737007712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007713 salt bridge; other site 1217737007714 non-specific DNA binding site [nucleotide binding]; other site 1217737007715 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007717 non-specific DNA binding site [nucleotide binding]; other site 1217737007718 salt bridge; other site 1217737007719 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1217737007721 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1217737007722 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1217737007723 Int/Topo IB signature motif; other site 1217737007724 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1217737007725 S-layer homology domain; Region: SLH; pfam00395 1217737007726 S-layer homology domain; Region: SLH; pfam00395 1217737007727 S-layer homology domain; Region: SLH; pfam00395 1217737007728 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737007729 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737007730 active site 1217737007731 metal binding site [ion binding]; metal-binding site 1217737007732 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1217737007733 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1217737007734 TQXA domain; Region: TQXA_dom; TIGR03934 1217737007735 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737007736 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737007737 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737007738 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737007739 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1217737007740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737007741 dimer interface [polypeptide binding]; other site 1217737007742 phosphorylation site [posttranslational modification] 1217737007743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737007744 ATP binding site [chemical binding]; other site 1217737007745 Mg2+ binding site [ion binding]; other site 1217737007746 G-X-G motif; other site 1217737007747 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1217737007748 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1217737007749 FOG: PKD repeat [General function prediction only]; Region: COG3291 1217737007750 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1217737007751 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1217737007752 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1217737007753 MgtC family; Region: MgtC; pfam02308 1217737007754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737007755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737007756 Coenzyme A binding pocket [chemical binding]; other site 1217737007757 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1217737007758 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1217737007759 putative metal binding site [ion binding]; other site 1217737007760 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1217737007761 active site 1217737007762 VanW like protein; Region: VanW; pfam04294 1217737007763 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1217737007764 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1217737007765 exonuclease; Provisional; Region: PRK06722 1217737007766 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1217737007767 active site 1217737007768 catalytic site [active] 1217737007769 substrate binding site [chemical binding]; other site 1217737007770 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737007771 DNA-binding site [nucleotide binding]; DNA binding site 1217737007772 RNA-binding motif; other site 1217737007773 flavodoxin; Provisional; Region: PRK06703 1217737007774 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1217737007775 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1217737007776 nudix motif; other site 1217737007777 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 1217737007778 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1217737007779 trimer interface [polypeptide binding]; other site 1217737007780 active site 1217737007781 substrate binding site [chemical binding]; other site 1217737007782 CoA binding site [chemical binding]; other site 1217737007783 Domain of unknown function DUF11; Region: DUF11; cl17728 1217737007784 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007785 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007786 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007787 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007788 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007789 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007790 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007791 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007792 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007793 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007794 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007795 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1217737007796 short chain dehydrogenase; Provisional; Region: PRK06924 1217737007797 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1217737007798 NADP binding site [chemical binding]; other site 1217737007799 homodimer interface [polypeptide binding]; other site 1217737007800 active site 1217737007801 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1217737007802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737007803 argininosuccinate lyase; Provisional; Region: PRK06705 1217737007804 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1217737007805 active sites [active] 1217737007806 tetramer interface [polypeptide binding]; other site 1217737007807 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737007808 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737007809 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1217737007810 active site 1217737007811 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1217737007812 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1217737007813 Na binding site [ion binding]; other site 1217737007814 Protein of unknown function (DUF997); Region: DUF997; pfam06196 1217737007815 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1217737007816 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1217737007817 NAD(P) binding site [chemical binding]; other site 1217737007818 catalytic residues [active] 1217737007819 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1217737007820 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1217737007821 NAD(P) binding site [chemical binding]; other site 1217737007822 homotetramer interface [polypeptide binding]; other site 1217737007823 homodimer interface [polypeptide binding]; other site 1217737007824 active site 1217737007825 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1217737007826 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1217737007827 Divergent PAP2 family; Region: DUF212; pfam02681 1217737007828 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1217737007829 EamA-like transporter family; Region: EamA; pfam00892 1217737007830 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1217737007831 Domain of unknown function DUF59; Region: DUF59; pfam01883 1217737007832 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1217737007833 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1217737007834 Walker A motif; other site 1217737007835 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1217737007836 MoaE interaction surface [polypeptide binding]; other site 1217737007837 MoeB interaction surface [polypeptide binding]; other site 1217737007838 thiocarboxylated glycine; other site 1217737007839 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1217737007840 MoaE homodimer interface [polypeptide binding]; other site 1217737007841 MoaD interaction [polypeptide binding]; other site 1217737007842 active site residues [active] 1217737007843 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1217737007844 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1217737007845 dimer interface [polypeptide binding]; other site 1217737007846 putative functional site; other site 1217737007847 putative MPT binding site; other site 1217737007848 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1217737007849 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1217737007850 ATP binding site [chemical binding]; other site 1217737007851 substrate interface [chemical binding]; other site 1217737007852 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1217737007853 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1217737007854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737007855 FeS/SAM binding site; other site 1217737007856 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1217737007857 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1217737007858 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1217737007859 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1217737007860 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1217737007861 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1217737007862 [4Fe-4S] binding site [ion binding]; other site 1217737007863 molybdopterin cofactor binding site; other site 1217737007864 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1217737007865 molybdopterin cofactor binding site; other site 1217737007866 Helix-turn-helix domain; Region: HTH_36; pfam13730 1217737007867 Replication-relaxation; Region: Replic_Relax; pfam13814 1217737007868 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737007869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007870 non-specific DNA binding site [nucleotide binding]; other site 1217737007871 salt bridge; other site 1217737007872 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007873 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737007874 amidase catalytic site [active] 1217737007875 Zn binding residues [ion binding]; other site 1217737007876 substrate binding site [chemical binding]; other site 1217737007877 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737007878 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1217737007879 Haemolysin XhlA; Region: XhlA; pfam10779 1217737007880 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1217737007881 H-type lectin domain; Region: H_lectin; pfam09458 1217737007882 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 1217737007883 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737007884 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737007885 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737007886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1217737007887 Terminase-like family; Region: Terminase_6; pfam03237 1217737007888 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1217737007889 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737007890 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737007891 catalytic residues [active] 1217737007892 catalytic nucleophile [active] 1217737007893 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737007894 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737007895 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737007896 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737007897 DNA binding site [nucleotide binding] 1217737007898 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1217737007899 DNA-binding interface [nucleotide binding]; DNA binding site 1217737007900 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1217737007901 Prophage antirepressor [Transcription]; Region: COG3617 1217737007902 BRO family, N-terminal domain; Region: Bro-N; smart01040 1217737007903 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1217737007904 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1217737007905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737007906 Homeodomain-like domain; Region: HTH_23; cl17451 1217737007907 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1217737007908 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1217737007909 hypothetical protein; Provisional; Region: PRK03636 1217737007910 UPF0302 domain; Region: UPF0302; pfam08864 1217737007911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1217737007912 ATP binding site [chemical binding]; other site 1217737007913 Walker A motif; other site 1217737007914 Walker B motif; other site 1217737007915 potential frameshift: common BLAST hit: gi|376267432|ref|YP_005120144.1| prophage DNA replication protein 1217737007916 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 1217737007917 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1217737007918 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1217737007919 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737007920 DNA binding residues [nucleotide binding] 1217737007921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007922 non-specific DNA binding site [nucleotide binding]; other site 1217737007923 salt bridge; other site 1217737007924 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007926 non-specific DNA binding site [nucleotide binding]; other site 1217737007927 salt bridge; other site 1217737007928 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007929 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737007930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737007931 non-specific DNA binding site [nucleotide binding]; other site 1217737007932 salt bridge; other site 1217737007933 sequence-specific DNA binding site [nucleotide binding]; other site 1217737007934 integrase; Provisional; Region: int; PHA02601 1217737007935 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1217737007936 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1217737007937 Int/Topo IB signature motif; other site 1217737007938 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1217737007939 catalytic loop [active] 1217737007940 iron binding site [ion binding]; other site 1217737007941 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1217737007942 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1217737007943 potential frameshift: common BLAST hit: gi|218898666|ref|YP_002447077.1| spore germination protein 1217737007944 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1217737007945 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737007946 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737007947 Tubulin like; Region: Tubulin_2; pfam13809 1217737007948 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1217737007949 metal ion-dependent adhesion site (MIDAS); other site 1217737007950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737007951 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737007952 active site 1217737007953 metal binding site [ion binding]; metal-binding site 1217737007954 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1217737007955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737007956 S-adenosylmethionine binding site [chemical binding]; other site 1217737007957 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737007958 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737007959 peptide binding site [polypeptide binding]; other site 1217737007960 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737007961 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737007962 peptide binding site [polypeptide binding]; other site 1217737007963 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737007964 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737007965 peptide binding site [polypeptide binding]; other site 1217737007966 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1217737007967 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1217737007968 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1217737007969 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1217737007970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737007971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737007972 DNA binding residues [nucleotide binding] 1217737007973 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1217737007974 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737007975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737007976 Walker A/P-loop; other site 1217737007977 ATP binding site [chemical binding]; other site 1217737007978 Q-loop/lid; other site 1217737007979 ABC transporter signature motif; other site 1217737007980 Walker B; other site 1217737007981 D-loop; other site 1217737007982 H-loop/switch region; other site 1217737007983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737007984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737007985 Predicted transcriptional regulator [Transcription]; Region: COG2378 1217737007986 HTH domain; Region: HTH_11; pfam08279 1217737007987 WYL domain; Region: WYL; pfam13280 1217737007988 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1217737007989 dimer interface [polypeptide binding]; other site 1217737007990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737007991 putative oxidoreductase; Provisional; Region: PRK11579 1217737007992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1217737007993 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1217737007994 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1217737007995 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1217737007996 CAP-like domain; other site 1217737007997 active site 1217737007998 primary dimer interface [polypeptide binding]; other site 1217737007999 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737008000 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737008001 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737008002 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737008003 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1217737008004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737008005 ATP binding site [chemical binding]; other site 1217737008006 Mg2+ binding site [ion binding]; other site 1217737008007 G-X-G motif; other site 1217737008008 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1217737008009 anchoring element; other site 1217737008010 dimer interface [polypeptide binding]; other site 1217737008011 ATP binding site [chemical binding]; other site 1217737008012 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1217737008013 active site 1217737008014 putative metal-binding site [ion binding]; other site 1217737008015 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1217737008016 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1217737008017 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1217737008018 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1217737008019 protein binding site [polypeptide binding]; other site 1217737008020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737008021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737008022 active site 1217737008023 phosphorylation site [posttranslational modification] 1217737008024 intermolecular recognition site; other site 1217737008025 dimerization interface [polypeptide binding]; other site 1217737008026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737008027 DNA binding site [nucleotide binding] 1217737008028 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1217737008029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737008030 FeS/SAM binding site; other site 1217737008031 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 1217737008032 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1217737008033 effector binding site; other site 1217737008034 active site 1217737008035 Zn binding site [ion binding]; other site 1217737008036 glycine loop; other site 1217737008037 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1217737008038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1217737008039 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1217737008040 active site 1217737008041 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1217737008042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737008043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737008044 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1217737008045 active site 1217737008046 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1217737008047 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1217737008048 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 1217737008049 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1217737008050 active site 1217737008051 catalytic site [active] 1217737008052 substrate binding site [chemical binding]; other site 1217737008053 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1217737008054 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1217737008055 catalytic residues [active] 1217737008056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737008057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737008058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737008059 Walker A/P-loop; other site 1217737008060 ATP binding site [chemical binding]; other site 1217737008061 Q-loop/lid; other site 1217737008062 ABC transporter signature motif; other site 1217737008063 Walker B; other site 1217737008064 D-loop; other site 1217737008065 H-loop/switch region; other site 1217737008066 aconitate hydratase; Validated; Region: PRK09277 1217737008067 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1217737008068 substrate binding site [chemical binding]; other site 1217737008069 ligand binding site [chemical binding]; other site 1217737008070 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1217737008071 substrate binding site [chemical binding]; other site 1217737008072 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1217737008073 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737008074 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1217737008075 NodB motif; other site 1217737008076 active site 1217737008077 catalytic site [active] 1217737008078 metal binding site [ion binding]; metal-binding site 1217737008079 Ras GTPase Activating Domain; Region: RasGAP; cl02569 1217737008080 Small acid-soluble spore protein P family; Region: SspP; cl12105 1217737008081 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1217737008082 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1217737008083 putative dimer interface [polypeptide binding]; other site 1217737008084 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1217737008085 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1217737008086 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1217737008087 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1217737008088 nudix motif; other site 1217737008089 SAP domain; Region: SAP; cl02640 1217737008090 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1217737008091 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1217737008092 dimer interface [polypeptide binding]; other site 1217737008093 active site 1217737008094 acyl-CoA synthetase; Validated; Region: PRK07638 1217737008095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1217737008096 acyl-activating enzyme (AAE) consensus motif; other site 1217737008097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1217737008098 acyl-activating enzyme (AAE) consensus motif; other site 1217737008099 AMP binding site [chemical binding]; other site 1217737008100 active site 1217737008101 CoA binding site [chemical binding]; other site 1217737008102 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1217737008103 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1217737008104 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1217737008105 dimer interface [polypeptide binding]; other site 1217737008106 acyl-activating enzyme (AAE) consensus motif; other site 1217737008107 putative active site [active] 1217737008108 AMP binding site [chemical binding]; other site 1217737008109 putative CoA binding site [chemical binding]; other site 1217737008110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737008111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737008112 non-specific DNA binding site [nucleotide binding]; other site 1217737008113 salt bridge; other site 1217737008114 sequence-specific DNA binding site [nucleotide binding]; other site 1217737008115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737008116 Coenzyme A binding pocket [chemical binding]; other site 1217737008117 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1217737008118 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737008119 amidase catalytic site [active] 1217737008120 Zn binding residues [ion binding]; other site 1217737008121 substrate binding site [chemical binding]; other site 1217737008122 active site 1217737008123 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1217737008124 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737008125 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737008126 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737008127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737008128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1217737008129 dimer interface [polypeptide binding]; other site 1217737008130 putative metal binding site [ion binding]; other site 1217737008131 PAS domain S-box; Region: sensory_box; TIGR00229 1217737008132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737008133 putative active site [active] 1217737008134 heme pocket [chemical binding]; other site 1217737008135 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1217737008136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737008137 putative active site [active] 1217737008138 heme pocket [chemical binding]; other site 1217737008139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737008140 dimer interface [polypeptide binding]; other site 1217737008141 phosphorylation site [posttranslational modification] 1217737008142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737008143 ATP binding site [chemical binding]; other site 1217737008144 Mg2+ binding site [ion binding]; other site 1217737008145 G-X-G motif; other site 1217737008146 Predicted esterase [General function prediction only]; Region: COG0400 1217737008147 putative hydrolase; Provisional; Region: PRK11460 1217737008148 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1217737008149 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737008150 Zn binding site [ion binding]; other site 1217737008151 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1217737008152 Zn binding site [ion binding]; other site 1217737008153 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1217737008154 Na binding site [ion binding]; other site 1217737008155 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1217737008156 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1217737008157 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1217737008158 active site 1217737008159 FMN binding site [chemical binding]; other site 1217737008160 substrate binding site [chemical binding]; other site 1217737008161 3Fe-4S cluster binding site [ion binding]; other site 1217737008162 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1217737008163 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1217737008164 FMN binding site [chemical binding]; other site 1217737008165 active site 1217737008166 substrate binding site [chemical binding]; other site 1217737008167 catalytic residue [active] 1217737008168 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1217737008169 agmatinase; Region: agmatinase; TIGR01230 1217737008170 Agmatinase-like family; Region: Agmatinase-like; cd09990 1217737008171 active site 1217737008172 oligomer interface [polypeptide binding]; other site 1217737008173 Mn binding site [ion binding]; other site 1217737008174 imidazolonepropionase; Validated; Region: PRK09356 1217737008175 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1217737008176 active site 1217737008177 urocanate hydratase; Provisional; Region: PRK05414 1217737008178 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1217737008179 active sites [active] 1217737008180 tetramer interface [polypeptide binding]; other site 1217737008181 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1217737008182 hexamer interface [polypeptide binding]; other site 1217737008183 RNA binding site [nucleotide binding]; other site 1217737008184 Histidine-zinc binding site [chemical binding]; other site 1217737008185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737008186 S-adenosylmethionine binding site [chemical binding]; other site 1217737008187 DJ-1 family protein; Region: not_thiJ; TIGR01383 1217737008188 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1217737008189 conserved cys residue [active] 1217737008190 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1217737008191 AAA domain; Region: AAA_28; pfam13521 1217737008192 active site 1217737008193 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1217737008194 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1217737008195 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1217737008196 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1217737008197 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737008198 EamA-like transporter family; Region: EamA; pfam00892 1217737008199 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1217737008200 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1217737008201 metal binding site [ion binding]; metal-binding site 1217737008202 dimer interface [polypeptide binding]; other site 1217737008203 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1217737008204 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1217737008205 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737008206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737008207 Walker A/P-loop; other site 1217737008208 ATP binding site [chemical binding]; other site 1217737008209 Q-loop/lid; other site 1217737008210 ABC transporter signature motif; other site 1217737008211 Walker B; other site 1217737008212 D-loop; other site 1217737008213 H-loop/switch region; other site 1217737008214 Probable transposase; Region: OrfB_IS605; pfam01385 1217737008215 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1217737008216 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1217737008217 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1217737008218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737008219 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1217737008220 putative dimerization interface [polypeptide binding]; other site 1217737008221 putative substrate binding pocket [chemical binding]; other site 1217737008222 holin-like protein; Validated; Region: PRK01658 1217737008223 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1217737008224 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1217737008225 nudix motif; other site 1217737008226 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 1217737008227 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737008228 Nuclease-related domain; Region: NERD; pfam08378 1217737008229 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1217737008230 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1217737008231 active site 1217737008232 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737008233 Bacterial SH3 domain; Region: SH3_3; cl17532 1217737008234 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737008235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737008236 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1217737008237 Walker A/P-loop; other site 1217737008238 ATP binding site [chemical binding]; other site 1217737008239 Q-loop/lid; other site 1217737008240 ABC transporter signature motif; other site 1217737008241 Walker B; other site 1217737008242 D-loop; other site 1217737008243 H-loop/switch region; other site 1217737008244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737008245 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1217737008246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737008247 Walker A/P-loop; other site 1217737008248 ATP binding site [chemical binding]; other site 1217737008249 Q-loop/lid; other site 1217737008250 ABC transporter signature motif; other site 1217737008251 Walker B; other site 1217737008252 D-loop; other site 1217737008253 H-loop/switch region; other site 1217737008254 hypothetical protein; Provisional; Region: PRK01844 1217737008255 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1217737008256 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1217737008257 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1217737008258 TPP-binding site [chemical binding]; other site 1217737008259 dimer interface [polypeptide binding]; other site 1217737008260 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1217737008261 PYR/PP interface [polypeptide binding]; other site 1217737008262 dimer interface [polypeptide binding]; other site 1217737008263 TPP binding site [chemical binding]; other site 1217737008264 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1217737008265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737008266 dimer interface [polypeptide binding]; other site 1217737008267 conserved gate region; other site 1217737008268 ABC-ATPase subunit interface; other site 1217737008269 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1217737008270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737008271 dimer interface [polypeptide binding]; other site 1217737008272 conserved gate region; other site 1217737008273 ABC-ATPase subunit interface; other site 1217737008274 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1217737008275 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1217737008276 Walker A/P-loop; other site 1217737008277 ATP binding site [chemical binding]; other site 1217737008278 Q-loop/lid; other site 1217737008279 ABC transporter signature motif; other site 1217737008280 Walker B; other site 1217737008281 D-loop; other site 1217737008282 H-loop/switch region; other site 1217737008283 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1217737008284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737008285 membrane-bound complex binding site; other site 1217737008286 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1217737008287 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1217737008288 active site 1217737008289 metal binding site [ion binding]; metal-binding site 1217737008290 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1217737008291 hypothetical protein; Provisional; Region: PRK01546 1217737008292 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737008293 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1217737008294 catalytic residues [active] 1217737008295 catalytic nucleophile [active] 1217737008296 LexA repressor; Validated; Region: PRK00215 1217737008297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737008298 putative DNA binding site [nucleotide binding]; other site 1217737008299 putative Zn2+ binding site [ion binding]; other site 1217737008300 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1217737008301 Catalytic site [active] 1217737008302 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1217737008303 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1217737008304 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1217737008305 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1217737008306 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737008307 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737008308 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1217737008309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1217737008310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1217737008311 catalytic residue [active] 1217737008312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1217737008313 DNA binding residues [nucleotide binding] 1217737008314 Helix-turn-helix domain; Region: HTH_36; pfam13730 1217737008315 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1217737008316 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1217737008317 ORF6C domain; Region: ORF6C; pfam10552 1217737008318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737008319 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1217737008320 non-specific DNA binding site [nucleotide binding]; other site 1217737008321 salt bridge; other site 1217737008322 sequence-specific DNA binding site [nucleotide binding]; other site 1217737008323 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1217737008324 Catalytic site [active] 1217737008325 glutamine synthetase, type I; Region: GlnA; TIGR00653 1217737008326 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1217737008327 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1217737008328 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1217737008329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737008330 DNA binding residues [nucleotide binding] 1217737008331 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1217737008332 Aluminium resistance protein; Region: Alum_res; pfam06838 1217737008333 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1217737008334 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1217737008335 HflX GTPase family; Region: HflX; cd01878 1217737008336 G1 box; other site 1217737008337 GTP/Mg2+ binding site [chemical binding]; other site 1217737008338 Switch I region; other site 1217737008339 G2 box; other site 1217737008340 G3 box; other site 1217737008341 Switch II region; other site 1217737008342 G4 box; other site 1217737008343 G5 box; other site 1217737008344 Predicted membrane protein [Function unknown]; Region: COG2860 1217737008345 UPF0126 domain; Region: UPF0126; pfam03458 1217737008346 UPF0126 domain; Region: UPF0126; pfam03458 1217737008347 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1217737008348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737008349 Walker A motif; other site 1217737008350 ATP binding site [chemical binding]; other site 1217737008351 Walker B motif; other site 1217737008352 arginine finger; other site 1217737008353 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1217737008354 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1217737008355 active site 1217737008356 catalytic residues [active] 1217737008357 DNA binding site [nucleotide binding] 1217737008358 Int/Topo IB signature motif; other site 1217737008359 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1217737008360 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1217737008361 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1217737008362 bacterial Hfq-like; Region: Hfq; cd01716 1217737008363 hexamer interface [polypeptide binding]; other site 1217737008364 Sm1 motif; other site 1217737008365 RNA binding site [nucleotide binding]; other site 1217737008366 Sm2 motif; other site 1217737008367 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1217737008368 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1217737008369 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737008370 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737008371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1217737008372 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1217737008373 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1217737008374 active site 1217737008375 phosphorylation site [posttranslational modification] 1217737008376 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1217737008377 active site 1217737008378 P-loop; other site 1217737008379 phosphorylation site [posttranslational modification] 1217737008380 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1217737008381 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1217737008382 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1217737008383 putative substrate binding site [chemical binding]; other site 1217737008384 putative ATP binding site [chemical binding]; other site 1217737008385 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1217737008386 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1217737008387 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1217737008388 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1217737008389 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1217737008390 dimer interface [polypeptide binding]; other site 1217737008391 active site 1217737008392 metal binding site [ion binding]; metal-binding site 1217737008393 Predicted membrane protein [Function unknown]; Region: COG2322 1217737008394 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1217737008395 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1217737008396 Glyco_18 domain; Region: Glyco_18; smart00636 1217737008397 putative active site [active] 1217737008398 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1217737008399 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1217737008400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737008401 putative active site [active] 1217737008402 putative metal binding site [ion binding]; other site 1217737008403 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1217737008404 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1217737008405 IHF dimer interface [polypeptide binding]; other site 1217737008406 IHF - DNA interface [nucleotide binding]; other site 1217737008407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737008408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737008409 Coenzyme A binding pocket [chemical binding]; other site 1217737008410 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1217737008411 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1217737008412 metal-binding site [ion binding] 1217737008413 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1217737008414 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1217737008415 metal-binding site [ion binding] 1217737008416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737008417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737008418 motif II; other site 1217737008419 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1217737008420 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1217737008421 metal-binding site [ion binding] 1217737008422 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1217737008423 putative homodimer interface [polypeptide binding]; other site 1217737008424 putative homotetramer interface [polypeptide binding]; other site 1217737008425 allosteric switch controlling residues; other site 1217737008426 putative metal binding site [ion binding]; other site 1217737008427 putative homodimer-homodimer interface [polypeptide binding]; other site 1217737008428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737008429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737008430 DNA binding residues [nucleotide binding] 1217737008431 dimerization interface [polypeptide binding]; other site 1217737008432 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737008433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737008434 S-adenosylmethionine binding site [chemical binding]; other site 1217737008435 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1217737008436 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1217737008437 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1217737008438 Walker A/P-loop; other site 1217737008439 ATP binding site [chemical binding]; other site 1217737008440 Q-loop/lid; other site 1217737008441 ABC transporter signature motif; other site 1217737008442 Walker B; other site 1217737008443 D-loop; other site 1217737008444 H-loop/switch region; other site 1217737008445 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1217737008446 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737008447 ABC-ATPase subunit interface; other site 1217737008448 dimer interface [polypeptide binding]; other site 1217737008449 putative PBP binding regions; other site 1217737008450 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1217737008451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737008452 ABC-ATPase subunit interface; other site 1217737008453 dimer interface [polypeptide binding]; other site 1217737008454 putative PBP binding regions; other site 1217737008455 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1217737008456 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1217737008457 putative ligand binding residues [chemical binding]; other site 1217737008458 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1217737008459 active site 1217737008460 putative catalytic site [active] 1217737008461 DNA binding site [nucleotide binding] 1217737008462 putative phosphate binding site [ion binding]; other site 1217737008463 metal binding site A [ion binding]; metal-binding site 1217737008464 AP binding site [nucleotide binding]; other site 1217737008465 metal binding site B [ion binding]; metal-binding site 1217737008466 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1217737008467 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1217737008468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737008469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737008470 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1217737008471 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1217737008472 DNA binding site [nucleotide binding] 1217737008473 active site 1217737008474 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1217737008475 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1217737008476 endonuclease III; Region: ENDO3c; smart00478 1217737008477 minor groove reading motif; other site 1217737008478 helix-hairpin-helix signature motif; other site 1217737008479 substrate binding pocket [chemical binding]; other site 1217737008480 active site 1217737008481 peptidase T; Region: peptidase-T; TIGR01882 1217737008482 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1217737008483 metal binding site [ion binding]; metal-binding site 1217737008484 dimer interface [polypeptide binding]; other site 1217737008485 Predicted membrane protein [Function unknown]; Region: COG2364 1217737008486 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737008487 hypothetical protein; Provisional; Region: PRK06764 1217737008488 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737008489 catalytic core [active] 1217737008490 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737008491 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1217737008492 PAS domain S-box; Region: sensory_box; TIGR00229 1217737008493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737008494 putative active site [active] 1217737008495 heme pocket [chemical binding]; other site 1217737008496 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737008497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737008498 metal binding site [ion binding]; metal-binding site 1217737008499 active site 1217737008500 I-site; other site 1217737008501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737008502 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1217737008503 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1217737008504 active site 1217737008505 homodimer interface [polypeptide binding]; other site 1217737008506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737008507 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1217737008508 NAD(P) binding site [chemical binding]; other site 1217737008509 active site 1217737008510 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1217737008511 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1217737008512 NAD(P) binding site [chemical binding]; other site 1217737008513 homodimer interface [polypeptide binding]; other site 1217737008514 substrate binding site [chemical binding]; other site 1217737008515 active site 1217737008516 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1217737008517 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1217737008518 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1217737008519 holin-like protein; Validated; Region: PRK01658 1217737008520 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737008521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737008522 DNA-binding site [nucleotide binding]; DNA binding site 1217737008523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737008524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737008525 homodimer interface [polypeptide binding]; other site 1217737008526 catalytic residue [active] 1217737008527 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1217737008528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737008529 dimerization interface [polypeptide binding]; other site 1217737008530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737008531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737008532 dimer interface [polypeptide binding]; other site 1217737008533 putative CheW interface [polypeptide binding]; other site 1217737008534 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 1217737008535 active site 1217737008536 catalytic site [active] 1217737008537 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1217737008538 putative active site [active] 1217737008539 putative catalytic triad [active] 1217737008540 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1217737008541 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737008542 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1217737008543 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737008544 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1217737008545 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1217737008546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1217737008547 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1217737008548 Sulfatase; Region: Sulfatase; pfam00884 1217737008549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737008550 binding surface 1217737008551 TPR motif; other site 1217737008552 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1217737008553 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1217737008554 G1 box; other site 1217737008555 GTP/Mg2+ binding site [chemical binding]; other site 1217737008556 Switch I region; other site 1217737008557 G3 box; other site 1217737008558 Switch II region; other site 1217737008559 G4 box; other site 1217737008560 G5 box; other site 1217737008561 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1217737008562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737008563 ATP binding site [chemical binding]; other site 1217737008564 Mg2+ binding site [ion binding]; other site 1217737008565 G-X-G motif; other site 1217737008566 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1217737008567 ATP binding site [chemical binding]; other site 1217737008568 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1217737008569 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1217737008570 MutS domain I; Region: MutS_I; pfam01624 1217737008571 MutS domain II; Region: MutS_II; pfam05188 1217737008572 MutS domain III; Region: MutS_III; pfam05192 1217737008573 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1217737008574 Walker A/P-loop; other site 1217737008575 ATP binding site [chemical binding]; other site 1217737008576 Q-loop/lid; other site 1217737008577 ABC transporter signature motif; other site 1217737008578 Walker B; other site 1217737008579 D-loop; other site 1217737008580 H-loop/switch region; other site 1217737008581 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1217737008582 Predicted membrane protein [Function unknown]; Region: COG4550 1217737008583 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1217737008584 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1217737008585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737008586 FeS/SAM binding site; other site 1217737008587 TRAM domain; Region: TRAM; pfam01938 1217737008588 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1217737008589 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1217737008590 TPP-binding site [chemical binding]; other site 1217737008591 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1217737008592 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1217737008593 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1217737008594 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1217737008595 dimer interface [polypeptide binding]; other site 1217737008596 PYR/PP interface [polypeptide binding]; other site 1217737008597 TPP binding site [chemical binding]; other site 1217737008598 substrate binding site [chemical binding]; other site 1217737008599 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1217737008600 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1217737008601 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1217737008602 active site 1217737008603 dimer interface [polypeptide binding]; other site 1217737008604 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1217737008605 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1217737008606 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737008607 putative active site [active] 1217737008608 metal binding site [ion binding]; metal-binding site 1217737008609 homodimer binding site [polypeptide binding]; other site 1217737008610 phosphodiesterase; Provisional; Region: PRK12704 1217737008611 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1217737008612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737008613 Zn2+ binding site [ion binding]; other site 1217737008614 Mg2+ binding site [ion binding]; other site 1217737008615 recombinase A; Provisional; Region: recA; PRK09354 1217737008616 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1217737008617 hexamer interface [polypeptide binding]; other site 1217737008618 Walker A motif; other site 1217737008619 ATP binding site [chemical binding]; other site 1217737008620 Walker B motif; other site 1217737008621 competence damage-inducible protein A; Provisional; Region: PRK00549 1217737008622 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1217737008623 putative MPT binding site; other site 1217737008624 Competence-damaged protein; Region: CinA; pfam02464 1217737008625 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1217737008626 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1217737008627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737008628 non-specific DNA binding site [nucleotide binding]; other site 1217737008629 salt bridge; other site 1217737008630 sequence-specific DNA binding site [nucleotide binding]; other site 1217737008631 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1217737008632 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1217737008633 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1217737008634 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1217737008635 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1217737008636 classical (c) SDRs; Region: SDR_c; cd05233 1217737008637 NAD(P) binding site [chemical binding]; other site 1217737008638 active site 1217737008639 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1217737008640 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1217737008641 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1217737008642 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1217737008643 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1217737008644 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1217737008645 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1217737008646 TM-ABC transporter signature motif; other site 1217737008647 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1217737008648 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1217737008649 TM-ABC transporter signature motif; other site 1217737008650 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1217737008651 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1217737008652 Walker A/P-loop; other site 1217737008653 ATP binding site [chemical binding]; other site 1217737008654 Q-loop/lid; other site 1217737008655 ABC transporter signature motif; other site 1217737008656 Walker B; other site 1217737008657 D-loop; other site 1217737008658 H-loop/switch region; other site 1217737008659 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1217737008660 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1217737008661 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1217737008662 ligand binding site [chemical binding]; other site 1217737008663 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1217737008664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737008665 DNA-binding site [nucleotide binding]; DNA binding site 1217737008666 UTRA domain; Region: UTRA; pfam07702 1217737008667 Tetraspanin family; Region: Tetraspannin; pfam00335 1217737008668 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1217737008669 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737008670 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1217737008671 YlzJ-like protein; Region: YlzJ; pfam14035 1217737008672 Clp protease; Region: CLP_protease; pfam00574 1217737008673 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1217737008674 active site 1217737008675 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1217737008676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737008677 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1217737008678 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1217737008679 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1217737008680 dimer interface [polypeptide binding]; other site 1217737008681 active site 1217737008682 catalytic residue [active] 1217737008683 aspartate kinase I; Reviewed; Region: PRK08210 1217737008684 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1217737008685 nucleotide binding site [chemical binding]; other site 1217737008686 substrate binding site [chemical binding]; other site 1217737008687 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1217737008688 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1217737008689 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1217737008690 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1217737008691 Flavoprotein; Region: Flavoprotein; cl08021 1217737008692 LXG domain of WXG superfamily; Region: LXG; pfam04740 1217737008693 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1217737008694 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1217737008695 active site 1217737008696 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1217737008697 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1217737008698 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1217737008699 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 1217737008700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737008701 Phage tail protein; Region: Sipho_tail; pfam05709 1217737008702 Phage tail protein; Region: Sipho_tail; cl17486 1217737008703 potential frameshift: common BLAST hit: gi|218898910|ref|YP_002447321.1| phage protein 1217737008704 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1217737008705 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1217737008706 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1217737008707 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1217737008708 oligomer interface [polypeptide binding]; other site 1217737008709 active site residues [active] 1217737008710 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1217737008711 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1217737008712 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1217737008713 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1217737008714 HNH endonuclease; Region: HNH; pfam01844 1217737008715 active site 1217737008716 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1217737008717 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1217737008718 dinuclear metal binding motif [ion binding]; other site 1217737008719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737008720 DNA-binding site [nucleotide binding]; DNA binding site 1217737008721 RNA-binding motif; other site 1217737008722 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1217737008723 Int/Topo IB signature motif; other site 1217737008724 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1217737008725 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1217737008726 replicative DNA helicase; Provisional; Region: PRK06749 1217737008727 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1217737008728 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1217737008729 Walker A motif; other site 1217737008730 ATP binding site [chemical binding]; other site 1217737008731 Walker B motif; other site 1217737008732 DNA binding loops [nucleotide binding] 1217737008733 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1217737008734 YjcQ protein; Region: YjcQ; pfam09639 1217737008735 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737008736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737008737 non-specific DNA binding site [nucleotide binding]; other site 1217737008738 salt bridge; other site 1217737008739 sequence-specific DNA binding site [nucleotide binding]; other site 1217737008740 transcriptional repressor DicA; Reviewed; Region: PRK09706 1217737008741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737008742 non-specific DNA binding site [nucleotide binding]; other site 1217737008743 salt bridge; other site 1217737008744 sequence-specific DNA binding site [nucleotide binding]; other site 1217737008745 Domain of unknown function (DUF955); Region: DUF955; cl01076 1217737008746 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 1217737008747 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737008748 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1217737008749 catalytic residues [active] 1217737008750 catalytic nucleophile [active] 1217737008751 Recombinase; Region: Recombinase; pfam07508 1217737008752 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1217737008753 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1217737008754 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1217737008755 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1217737008756 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1217737008757 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1217737008758 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1217737008759 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1217737008760 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1217737008761 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1217737008762 NodB motif; other site 1217737008763 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1217737008764 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1217737008765 RNase E interface [polypeptide binding]; other site 1217737008766 trimer interface [polypeptide binding]; other site 1217737008767 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1217737008768 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1217737008769 RNase E interface [polypeptide binding]; other site 1217737008770 trimer interface [polypeptide binding]; other site 1217737008771 active site 1217737008772 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1217737008773 putative nucleic acid binding region [nucleotide binding]; other site 1217737008774 G-X-X-G motif; other site 1217737008775 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1217737008776 RNA binding site [nucleotide binding]; other site 1217737008777 domain interface; other site 1217737008778 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1217737008779 16S/18S rRNA binding site [nucleotide binding]; other site 1217737008780 S13e-L30e interaction site [polypeptide binding]; other site 1217737008781 25S rRNA binding site [nucleotide binding]; other site 1217737008782 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1217737008783 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1217737008784 active site 1217737008785 Riboflavin kinase; Region: Flavokinase; pfam01687 1217737008786 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1217737008787 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1217737008788 RNA binding site [nucleotide binding]; other site 1217737008789 active site 1217737008790 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1217737008791 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1217737008792 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1217737008793 translation initiation factor IF-2; Region: IF-2; TIGR00487 1217737008794 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1217737008795 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1217737008796 G1 box; other site 1217737008797 putative GEF interaction site [polypeptide binding]; other site 1217737008798 GTP/Mg2+ binding site [chemical binding]; other site 1217737008799 Switch I region; other site 1217737008800 G2 box; other site 1217737008801 G3 box; other site 1217737008802 Switch II region; other site 1217737008803 G4 box; other site 1217737008804 G5 box; other site 1217737008805 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1217737008806 Translation-initiation factor 2; Region: IF-2; pfam11987 1217737008807 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1217737008808 hypothetical protein; Provisional; Region: PRK07714 1217737008809 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1217737008810 putative RNA binding cleft [nucleotide binding]; other site 1217737008811 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1217737008812 NusA N-terminal domain; Region: NusA_N; pfam08529 1217737008813 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1217737008814 RNA binding site [nucleotide binding]; other site 1217737008815 homodimer interface [polypeptide binding]; other site 1217737008816 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1217737008817 G-X-X-G motif; other site 1217737008818 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1217737008819 G-X-X-G motif; other site 1217737008820 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1217737008821 Sm and related proteins; Region: Sm_like; cl00259 1217737008822 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1217737008823 putative oligomer interface [polypeptide binding]; other site 1217737008824 putative RNA binding site [nucleotide binding]; other site 1217737008825 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1217737008826 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1217737008827 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1217737008828 generic binding surface II; other site 1217737008829 generic binding surface I; other site 1217737008830 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1217737008831 active site 1217737008832 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1217737008833 active site 1217737008834 catalytic site [active] 1217737008835 substrate binding site [chemical binding]; other site 1217737008836 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1217737008837 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1217737008838 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1217737008839 dimer interface [polypeptide binding]; other site 1217737008840 motif 1; other site 1217737008841 active site 1217737008842 motif 2; other site 1217737008843 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1217737008844 putative deacylase active site [active] 1217737008845 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1217737008846 active site 1217737008847 motif 3; other site 1217737008848 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1217737008849 anticodon binding site; other site 1217737008850 RIP metalloprotease RseP; Region: TIGR00054 1217737008851 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1217737008852 active site 1217737008853 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1217737008854 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1217737008855 protein binding site [polypeptide binding]; other site 1217737008856 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1217737008857 putative substrate binding region [chemical binding]; other site 1217737008858 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1217737008859 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1217737008860 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1217737008861 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1217737008862 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1217737008863 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1217737008864 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1217737008865 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1217737008866 catalytic residue [active] 1217737008867 putative FPP diphosphate binding site; other site 1217737008868 putative FPP binding hydrophobic cleft; other site 1217737008869 dimer interface [polypeptide binding]; other site 1217737008870 putative IPP diphosphate binding site; other site 1217737008871 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1217737008872 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1217737008873 hinge region; other site 1217737008874 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1217737008875 putative nucleotide binding site [chemical binding]; other site 1217737008876 uridine monophosphate binding site [chemical binding]; other site 1217737008877 homohexameric interface [polypeptide binding]; other site 1217737008878 elongation factor Ts; Provisional; Region: tsf; PRK09377 1217737008879 UBA/TS-N domain; Region: UBA; pfam00627 1217737008880 Elongation factor TS; Region: EF_TS; pfam00889 1217737008881 Elongation factor TS; Region: EF_TS; pfam00889 1217737008882 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1217737008883 rRNA interaction site [nucleotide binding]; other site 1217737008884 S8 interaction site; other site 1217737008885 putative laminin-1 binding site; other site 1217737008886 transcriptional repressor CodY; Validated; Region: PRK04158 1217737008887 CodY GAF-like domain; Region: CodY; pfam06018 1217737008888 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1217737008889 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1217737008890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737008891 Walker A motif; other site 1217737008892 ATP binding site [chemical binding]; other site 1217737008893 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1217737008894 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1217737008895 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1217737008896 active site 1217737008897 HslU subunit interaction site [polypeptide binding]; other site 1217737008898 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1217737008899 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1217737008900 active site 1217737008901 Int/Topo IB signature motif; other site 1217737008902 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1217737008903 Glucose inhibited division protein A; Region: GIDA; pfam01134 1217737008904 DNA topoisomerase I; Validated; Region: PRK05582 1217737008905 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1217737008906 active site 1217737008907 interdomain interaction site; other site 1217737008908 putative metal-binding site [ion binding]; other site 1217737008909 nucleotide binding site [chemical binding]; other site 1217737008910 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1217737008911 domain I; other site 1217737008912 DNA binding groove [nucleotide binding] 1217737008913 phosphate binding site [ion binding]; other site 1217737008914 domain II; other site 1217737008915 domain III; other site 1217737008916 nucleotide binding site [chemical binding]; other site 1217737008917 catalytic site [active] 1217737008918 domain IV; other site 1217737008919 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1217737008920 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1217737008921 DNA protecting protein DprA; Region: dprA; TIGR00732 1217737008922 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1217737008923 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1217737008924 CoA binding domain; Region: CoA_binding; smart00881 1217737008925 CoA-ligase; Region: Ligase_CoA; pfam00549 1217737008926 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1217737008927 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1217737008928 CoA-ligase; Region: Ligase_CoA; pfam00549 1217737008929 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1217737008930 RNA/DNA hybrid binding site [nucleotide binding]; other site 1217737008931 active site 1217737008932 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1217737008933 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1217737008934 GTP/Mg2+ binding site [chemical binding]; other site 1217737008935 G4 box; other site 1217737008936 G5 box; other site 1217737008937 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1217737008938 G1 box; other site 1217737008939 G1 box; other site 1217737008940 GTP/Mg2+ binding site [chemical binding]; other site 1217737008941 Switch I region; other site 1217737008942 G2 box; other site 1217737008943 G2 box; other site 1217737008944 G3 box; other site 1217737008945 G3 box; other site 1217737008946 Switch II region; other site 1217737008947 Switch II region; other site 1217737008948 G4 box; other site 1217737008949 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1217737008950 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1217737008951 Catalytic site [active] 1217737008952 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1217737008953 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1217737008954 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1217737008955 RimM N-terminal domain; Region: RimM; pfam01782 1217737008956 PRC-barrel domain; Region: PRC; pfam05239 1217737008957 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1217737008958 KH domain; Region: KH_4; pfam13083 1217737008959 G-X-X-G motif; other site 1217737008960 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1217737008961 signal recognition particle protein; Provisional; Region: PRK10867 1217737008962 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1217737008963 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1217737008964 P loop; other site 1217737008965 GTP binding site [chemical binding]; other site 1217737008966 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1217737008967 putative DNA-binding protein; Validated; Region: PRK00118 1217737008968 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1217737008969 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1217737008970 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1217737008971 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1217737008972 P loop; other site 1217737008973 GTP binding site [chemical binding]; other site 1217737008974 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1217737008975 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1217737008976 Walker A/P-loop; other site 1217737008977 ATP binding site [chemical binding]; other site 1217737008978 Q-loop/lid; other site 1217737008979 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1217737008980 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1217737008981 ABC transporter signature motif; other site 1217737008982 Walker B; other site 1217737008983 D-loop; other site 1217737008984 H-loop/switch region; other site 1217737008985 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1217737008986 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1217737008987 dimerization interface [polypeptide binding]; other site 1217737008988 active site 1217737008989 metal binding site [ion binding]; metal-binding site 1217737008990 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1217737008991 dsRNA binding site [nucleotide binding]; other site 1217737008992 acyl carrier protein; Provisional; Region: acpP; PRK00982 1217737008993 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1217737008994 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1217737008995 NAD(P) binding site [chemical binding]; other site 1217737008996 homotetramer interface [polypeptide binding]; other site 1217737008997 homodimer interface [polypeptide binding]; other site 1217737008998 active site 1217737008999 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1217737009000 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1217737009001 putative phosphate acyltransferase; Provisional; Region: PRK05331 1217737009002 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1217737009003 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1217737009004 active site 2 [active] 1217737009005 active site 1 [active] 1217737009006 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1217737009007 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1217737009008 generic binding surface II; other site 1217737009009 ssDNA binding site; other site 1217737009010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737009011 ATP binding site [chemical binding]; other site 1217737009012 putative Mg++ binding site [ion binding]; other site 1217737009013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737009014 nucleotide binding region [chemical binding]; other site 1217737009015 ATP-binding site [chemical binding]; other site 1217737009016 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1217737009017 DAK2 domain; Region: Dak2; pfam02734 1217737009018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1217737009019 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1217737009020 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1217737009021 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1217737009022 Thiamine pyrophosphokinase; Region: TPK; cd07995 1217737009023 active site 1217737009024 dimerization interface [polypeptide binding]; other site 1217737009025 thiamine binding site [chemical binding]; other site 1217737009026 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1217737009027 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1217737009028 substrate binding site [chemical binding]; other site 1217737009029 hexamer interface [polypeptide binding]; other site 1217737009030 metal binding site [ion binding]; metal-binding site 1217737009031 GTPase RsgA; Reviewed; Region: PRK00098 1217737009032 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1217737009033 RNA binding site [nucleotide binding]; other site 1217737009034 homodimer interface [polypeptide binding]; other site 1217737009035 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1217737009036 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1217737009037 GTP/Mg2+ binding site [chemical binding]; other site 1217737009038 G4 box; other site 1217737009039 G5 box; other site 1217737009040 G1 box; other site 1217737009041 Switch I region; other site 1217737009042 G2 box; other site 1217737009043 G3 box; other site 1217737009044 Switch II region; other site 1217737009045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1217737009046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1217737009047 active site 1217737009048 ATP binding site [chemical binding]; other site 1217737009049 substrate binding site [chemical binding]; other site 1217737009050 activation loop (A-loop); other site 1217737009051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1217737009052 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1217737009053 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1217737009054 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1217737009055 Protein phosphatase 2C; Region: PP2C; pfam00481 1217737009056 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1217737009057 active site 1217737009058 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1217737009059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737009060 FeS/SAM binding site; other site 1217737009061 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1217737009062 NusB family; Region: NusB; pfam01029 1217737009063 putative RNA binding site [nucleotide binding]; other site 1217737009064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737009065 S-adenosylmethionine binding site [chemical binding]; other site 1217737009066 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1217737009067 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1217737009068 putative active site [active] 1217737009069 substrate binding site [chemical binding]; other site 1217737009070 putative cosubstrate binding site; other site 1217737009071 catalytic site [active] 1217737009072 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1217737009073 substrate binding site [chemical binding]; other site 1217737009074 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1217737009075 active site 1217737009076 catalytic residues [active] 1217737009077 metal binding site [ion binding]; metal-binding site 1217737009078 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1217737009079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737009080 ATP binding site [chemical binding]; other site 1217737009081 putative Mg++ binding site [ion binding]; other site 1217737009082 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1217737009083 nucleotide binding region [chemical binding]; other site 1217737009084 ATP-binding site [chemical binding]; other site 1217737009085 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1217737009086 Flavoprotein; Region: Flavoprotein; pfam02441 1217737009087 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1217737009088 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1217737009089 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1217737009090 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1217737009091 catalytic site [active] 1217737009092 G-X2-G-X-G-K; other site 1217737009093 hypothetical protein; Provisional; Region: PRK04323 1217737009094 hypothetical protein; Provisional; Region: PRK11820 1217737009095 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1217737009096 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1217737009097 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1217737009098 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1217737009099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737009100 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1217737009101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737009102 motif II; other site 1217737009103 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1217737009104 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1217737009105 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1217737009106 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1217737009107 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1217737009108 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1217737009109 active site 1217737009110 DinB superfamily; Region: DinB_2; pfam12867 1217737009111 YoqO-like protein; Region: YoqO; pfam14037 1217737009112 YoqO-like protein; Region: YoqO; pfam14037 1217737009113 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1217737009114 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1217737009115 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737009116 active site 1217737009117 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1217737009118 active site 1217737009119 dimer interface [polypeptide binding]; other site 1217737009120 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1217737009121 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1217737009122 heterodimer interface [polypeptide binding]; other site 1217737009123 active site 1217737009124 FMN binding site [chemical binding]; other site 1217737009125 homodimer interface [polypeptide binding]; other site 1217737009126 substrate binding site [chemical binding]; other site 1217737009127 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1217737009128 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1217737009129 FAD binding pocket [chemical binding]; other site 1217737009130 FAD binding motif [chemical binding]; other site 1217737009131 phosphate binding motif [ion binding]; other site 1217737009132 beta-alpha-beta structure motif; other site 1217737009133 NAD binding pocket [chemical binding]; other site 1217737009134 Iron coordination center [ion binding]; other site 1217737009135 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1217737009136 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1217737009137 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1217737009138 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1217737009139 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1217737009140 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1217737009141 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1217737009142 IMP binding site; other site 1217737009143 dimer interface [polypeptide binding]; other site 1217737009144 interdomain contacts; other site 1217737009145 partial ornithine binding site; other site 1217737009146 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1217737009147 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1217737009148 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1217737009149 catalytic site [active] 1217737009150 subunit interface [polypeptide binding]; other site 1217737009151 dihydroorotase; Validated; Region: pyrC; PRK09357 1217737009152 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1217737009153 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1217737009154 active site 1217737009155 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1217737009156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1217737009157 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1217737009158 uracil transporter; Provisional; Region: PRK10720 1217737009159 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1217737009160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737009161 active site 1217737009162 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1217737009163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737009164 RNA binding surface [nucleotide binding]; other site 1217737009165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1217737009166 active site 1217737009167 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1217737009168 lipoprotein signal peptidase; Provisional; Region: PRK14787 1217737009169 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1217737009170 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1217737009171 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1217737009172 active site 1217737009173 HIGH motif; other site 1217737009174 nucleotide binding site [chemical binding]; other site 1217737009175 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1217737009176 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1217737009177 active site 1217737009178 KMSKS motif; other site 1217737009179 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1217737009180 tRNA binding surface [nucleotide binding]; other site 1217737009181 anticodon binding site; other site 1217737009182 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1217737009183 DivIVA protein; Region: DivIVA; pfam05103 1217737009184 DivIVA domain; Region: DivI1A_domain; TIGR03544 1217737009185 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1217737009186 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1217737009187 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737009188 RNA binding surface [nucleotide binding]; other site 1217737009189 YGGT family; Region: YGGT; pfam02325 1217737009190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1217737009191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1217737009192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1217737009193 catalytic residue [active] 1217737009194 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1217737009195 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1217737009196 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1217737009197 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1217737009198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737009199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737009200 DNA binding residues [nucleotide binding] 1217737009201 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1217737009202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737009203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737009204 DNA binding residues [nucleotide binding] 1217737009205 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1217737009206 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1217737009207 cell division protein FtsZ; Validated; Region: PRK09330 1217737009208 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1217737009209 nucleotide binding site [chemical binding]; other site 1217737009210 SulA interaction site; other site 1217737009211 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1217737009212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1217737009213 nucleotide binding site [chemical binding]; other site 1217737009214 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1217737009215 Cell division protein FtsA; Region: FtsA; pfam14450 1217737009216 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1217737009217 Cell division protein FtsQ; Region: FtsQ; pfam03799 1217737009218 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1217737009219 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737009220 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1217737009221 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1217737009222 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1217737009223 active site 1217737009224 homodimer interface [polypeptide binding]; other site 1217737009225 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1217737009226 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1217737009227 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1217737009228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1217737009229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1217737009230 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1217737009231 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1217737009232 Mg++ binding site [ion binding]; other site 1217737009233 putative catalytic motif [active] 1217737009234 putative substrate binding site [chemical binding]; other site 1217737009235 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1217737009236 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1217737009237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1217737009238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1217737009239 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1217737009240 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737009241 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737009242 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1217737009243 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737009244 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737009245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737009246 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1217737009247 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1217737009248 Cell division protein FtsL; Region: FtsL; cl11433 1217737009249 MraW methylase family; Region: Methyltransf_5; pfam01795 1217737009250 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1217737009251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1217737009252 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1217737009253 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1217737009254 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1217737009255 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1217737009256 hypothetical protein; Provisional; Region: PRK13688 1217737009257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737009258 Coenzyme A binding pocket [chemical binding]; other site 1217737009259 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1217737009260 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1217737009261 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1217737009262 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1217737009263 hypothetical protein; Provisional; Region: PRK13670 1217737009264 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1217737009265 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1217737009266 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1217737009267 protein binding site [polypeptide binding]; other site 1217737009268 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1217737009269 hypothetical protein; Provisional; Region: PRK10279 1217737009270 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1217737009271 active site 1217737009272 nucleophile elbow; other site 1217737009273 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1217737009274 Nucleoside recognition; Region: Gate; pfam07670 1217737009275 Nucleoside recognition; Region: Gate; pfam07670 1217737009276 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1217737009277 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1217737009278 active site 1217737009279 (T/H)XGH motif; other site 1217737009280 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1217737009281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737009282 S-adenosylmethionine binding site [chemical binding]; other site 1217737009283 hypothetical protein; Provisional; Region: PRK02886 1217737009284 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1217737009285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737009286 catalytic core [active] 1217737009287 YlbE-like protein; Region: YlbE; pfam14003 1217737009288 Putative coat protein; Region: YlbD_coat; pfam14071 1217737009289 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1217737009290 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1217737009291 YugN-like family; Region: YugN; pfam08868 1217737009292 formamidase; Provisional; Region: amiF; PRK13287 1217737009293 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1217737009294 multimer interface [polypeptide binding]; other site 1217737009295 active site 1217737009296 catalytic triad [active] 1217737009297 dimer interface [polypeptide binding]; other site 1217737009298 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1217737009299 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1217737009300 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1217737009301 Subunit I/III interface [polypeptide binding]; other site 1217737009302 Subunit III/IV interface [polypeptide binding]; other site 1217737009303 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1217737009304 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1217737009305 D-pathway; other site 1217737009306 Putative ubiquinol binding site [chemical binding]; other site 1217737009307 Low-spin heme (heme b) binding site [chemical binding]; other site 1217737009308 Putative water exit pathway; other site 1217737009309 Binuclear center (heme o3/CuB) [ion binding]; other site 1217737009310 K-pathway; other site 1217737009311 Putative proton exit pathway; other site 1217737009312 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1217737009313 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1217737009314 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1217737009315 Cytochrome c; Region: Cytochrom_C; pfam00034 1217737009316 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1217737009317 UbiA prenyltransferase family; Region: UbiA; pfam01040 1217737009318 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1217737009319 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1217737009320 pyruvate carboxylase; Reviewed; Region: PRK12999 1217737009321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1217737009322 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1217737009323 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1217737009324 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1217737009325 active site 1217737009326 catalytic residues [active] 1217737009327 metal binding site [ion binding]; metal-binding site 1217737009328 homodimer binding site [polypeptide binding]; other site 1217737009329 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1217737009330 carboxyltransferase (CT) interaction site; other site 1217737009331 biotinylation site [posttranslational modification]; other site 1217737009332 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1217737009333 hypothetical protein; Provisional; Region: PRK13666 1217737009334 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1217737009335 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1217737009336 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1217737009337 putative active site [active] 1217737009338 PhoH-like protein; Region: PhoH; pfam02562 1217737009339 hypothetical protein; Provisional; Region: PRK06733 1217737009340 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1217737009341 YlaH-like protein; Region: YlaH; pfam14036 1217737009342 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1217737009343 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1217737009344 G1 box; other site 1217737009345 putative GEF interaction site [polypeptide binding]; other site 1217737009346 GTP/Mg2+ binding site [chemical binding]; other site 1217737009347 Switch I region; other site 1217737009348 G2 box; other site 1217737009349 G3 box; other site 1217737009350 Switch II region; other site 1217737009351 G4 box; other site 1217737009352 G5 box; other site 1217737009353 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1217737009354 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1217737009355 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1217737009356 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1217737009357 active site 1217737009358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1217737009359 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1217737009360 hypothetical protein; Provisional; Region: PRK04387 1217737009361 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1217737009362 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1217737009363 homodimer interface [polypeptide binding]; other site 1217737009364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737009365 catalytic residue [active] 1217737009366 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1217737009367 transglutaminase; Provisional; Region: tgl; PRK03187 1217737009368 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1217737009369 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1217737009370 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1217737009371 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1217737009372 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 1217737009373 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1217737009374 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737009375 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1217737009376 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1217737009377 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1217737009378 E3 interaction surface; other site 1217737009379 lipoyl attachment site [posttranslational modification]; other site 1217737009380 e3 binding domain; Region: E3_binding; pfam02817 1217737009381 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1217737009382 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1217737009383 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1217737009384 alpha subunit interface [polypeptide binding]; other site 1217737009385 TPP binding site [chemical binding]; other site 1217737009386 heterodimer interface [polypeptide binding]; other site 1217737009387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1217737009388 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1217737009389 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1217737009390 TPP-binding site [chemical binding]; other site 1217737009391 heterodimer interface [polypeptide binding]; other site 1217737009392 tetramer interface [polypeptide binding]; other site 1217737009393 phosphorylation loop region [posttranslational modification] 1217737009394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1217737009395 active site 1217737009396 catalytic residues [active] 1217737009397 metal binding site [ion binding]; metal-binding site 1217737009398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737009399 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737009400 active site 1217737009401 motif I; other site 1217737009402 motif II; other site 1217737009403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737009404 hypothetical protein; Provisional; Region: PRK13667 1217737009405 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1217737009406 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737009407 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1217737009408 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1217737009409 TrkA-N domain; Region: TrkA_N; pfam02254 1217737009410 TrkA-C domain; Region: TrkA_C; pfam02080 1217737009411 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1217737009412 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1217737009413 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1217737009414 metal binding site [ion binding]; metal-binding site 1217737009415 putative dimer interface [polypeptide binding]; other site 1217737009416 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1217737009417 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1217737009418 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1217737009419 trimer interface [polypeptide binding]; other site 1217737009420 active site 1217737009421 substrate binding site [chemical binding]; other site 1217737009422 CoA binding site [chemical binding]; other site 1217737009423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737009424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737009425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737009426 dimerization interface [polypeptide binding]; other site 1217737009427 FOG: CBS domain [General function prediction only]; Region: COG0517 1217737009428 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1217737009429 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1217737009430 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1217737009431 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1217737009432 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1217737009433 catalytic residues [active] 1217737009434 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 1217737009435 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737009436 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1217737009437 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1217737009438 short chain dehydrogenase; Provisional; Region: PRK07677 1217737009439 NAD(P) binding site [chemical binding]; other site 1217737009440 substrate binding site [chemical binding]; other site 1217737009441 homotetramer interface [polypeptide binding]; other site 1217737009442 active site 1217737009443 homodimer interface [polypeptide binding]; other site 1217737009444 phosphodiesterase YaeI; Provisional; Region: PRK11340 1217737009445 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1217737009446 putative active site [active] 1217737009447 putative metal binding site [ion binding]; other site 1217737009448 polyphosphate kinase; Provisional; Region: PRK05443 1217737009449 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1217737009450 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1217737009451 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1217737009452 putative domain interface [polypeptide binding]; other site 1217737009453 putative active site [active] 1217737009454 catalytic site [active] 1217737009455 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1217737009456 putative domain interface [polypeptide binding]; other site 1217737009457 putative active site [active] 1217737009458 catalytic site [active] 1217737009459 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1217737009460 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1217737009461 nucleotide binding site [chemical binding]; other site 1217737009462 YkyB-like protein; Region: YkyB; pfam14177 1217737009463 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1217737009464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737009465 I-site; other site 1217737009466 active site 1217737009467 metal binding site [ion binding]; metal-binding site 1217737009468 Phage lysis protein, holin; Region: Phage_holin; cl04675 1217737009469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737009470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737009471 putative substrate translocation pore; other site 1217737009472 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737009473 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1217737009474 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1217737009475 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1217737009476 THF binding site; other site 1217737009477 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1217737009478 substrate binding site [chemical binding]; other site 1217737009479 THF binding site; other site 1217737009480 zinc-binding site [ion binding]; other site 1217737009481 Competence protein J (ComJ); Region: ComJ; pfam11033 1217737009482 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1217737009483 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 1217737009484 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1217737009485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737009486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737009487 dimer interface [polypeptide binding]; other site 1217737009488 phosphorylation site [posttranslational modification] 1217737009489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737009490 ATP binding site [chemical binding]; other site 1217737009491 Mg2+ binding site [ion binding]; other site 1217737009492 G-X-G motif; other site 1217737009493 aminotransferase A; Validated; Region: PRK07683 1217737009494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737009495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737009496 homodimer interface [polypeptide binding]; other site 1217737009497 catalytic residue [active] 1217737009498 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737009499 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737009500 DNA binding site [nucleotide binding] 1217737009501 domain linker motif; other site 1217737009502 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1217737009503 putative dimerization interface [polypeptide binding]; other site 1217737009504 putative ligand binding site [chemical binding]; other site 1217737009505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1217737009506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737009507 dimer interface [polypeptide binding]; other site 1217737009508 conserved gate region; other site 1217737009509 putative PBP binding loops; other site 1217737009510 ABC-ATPase subunit interface; other site 1217737009511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737009512 dimer interface [polypeptide binding]; other site 1217737009513 conserved gate region; other site 1217737009514 putative PBP binding loops; other site 1217737009515 ABC-ATPase subunit interface; other site 1217737009516 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1217737009517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1217737009518 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1217737009519 homodimer interface [polypeptide binding]; other site 1217737009520 maltodextrin glucosidase; Provisional; Region: PRK10785 1217737009521 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1217737009522 active site 1217737009523 homodimer interface [polypeptide binding]; other site 1217737009524 catalytic site [active] 1217737009525 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1217737009526 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1217737009527 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1217737009528 Ca binding site [ion binding]; other site 1217737009529 active site 1217737009530 catalytic site [active] 1217737009531 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1217737009532 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1217737009533 Walker A/P-loop; other site 1217737009534 ATP binding site [chemical binding]; other site 1217737009535 Q-loop/lid; other site 1217737009536 ABC transporter signature motif; other site 1217737009537 Walker B; other site 1217737009538 D-loop; other site 1217737009539 H-loop/switch region; other site 1217737009540 TOBE domain; Region: TOBE_2; pfam08402 1217737009541 hypothetical protein; Provisional; Region: PRK06720 1217737009542 NAD(P) binding site [chemical binding]; other site 1217737009543 RDD family; Region: RDD; pfam06271 1217737009544 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 1217737009545 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1217737009546 Predicted ATPase [General function prediction only]; Region: COG3910 1217737009547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737009548 Walker A/P-loop; other site 1217737009549 ATP binding site [chemical binding]; other site 1217737009550 Q-loop/lid; other site 1217737009551 ABC transporter signature motif; other site 1217737009552 Walker B; other site 1217737009553 D-loop; other site 1217737009554 H-loop/switch region; other site 1217737009555 putative acyltransferase; Provisional; Region: PRK05790 1217737009556 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1217737009557 dimer interface [polypeptide binding]; other site 1217737009558 active site 1217737009559 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1217737009560 nudix motif; other site 1217737009561 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 1217737009562 hypothetical protein; Validated; Region: PRK07668 1217737009563 hypothetical protein; Validated; Region: PRK07668 1217737009564 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737009565 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737009566 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1217737009567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737009568 NAD(P) binding site [chemical binding]; other site 1217737009569 active site 1217737009570 YvrJ protein family; Region: YvrJ; pfam12841 1217737009571 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1217737009572 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1217737009573 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1217737009574 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737009575 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1217737009576 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1217737009577 putative active site [active] 1217737009578 catalytic triad [active] 1217737009579 putative dimer interface [polypeptide binding]; other site 1217737009580 transaminase; Reviewed; Region: PRK08068 1217737009581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737009582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737009583 homodimer interface [polypeptide binding]; other site 1217737009584 catalytic residue [active] 1217737009585 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1217737009586 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1217737009587 dimer interface [polypeptide binding]; other site 1217737009588 active site 1217737009589 catalytic residue [active] 1217737009590 metal binding site [ion binding]; metal-binding site 1217737009591 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 1217737009592 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1217737009593 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1217737009594 intersubunit interface [polypeptide binding]; other site 1217737009595 active site 1217737009596 Zn2+ binding site [ion binding]; other site 1217737009597 ARD/ARD' family; Region: ARD; pfam03079 1217737009598 Cupin domain; Region: Cupin_2; pfam07883 1217737009599 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 1217737009600 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1217737009601 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1217737009602 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1217737009603 Beta-lactamase; Region: Beta-lactamase; pfam00144 1217737009604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737009605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737009606 metal binding site [ion binding]; metal-binding site 1217737009607 active site 1217737009608 I-site; other site 1217737009609 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1217737009610 dimer interface [polypeptide binding]; other site 1217737009611 FMN binding site [chemical binding]; other site 1217737009612 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 1217737009613 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1217737009614 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1217737009615 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1217737009616 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1217737009617 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1217737009618 dimerization domain swap beta strand [polypeptide binding]; other site 1217737009619 regulatory protein interface [polypeptide binding]; other site 1217737009620 active site 1217737009621 regulatory phosphorylation site [posttranslational modification]; other site 1217737009622 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1217737009623 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1217737009624 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1217737009625 active site turn [active] 1217737009626 phosphorylation site [posttranslational modification] 1217737009627 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1217737009628 HPr interaction site; other site 1217737009629 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1217737009630 active site 1217737009631 phosphorylation site [posttranslational modification] 1217737009632 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1217737009633 CAT RNA binding domain; Region: CAT_RBD; smart01061 1217737009634 PRD domain; Region: PRD; pfam00874 1217737009635 PRD domain; Region: PRD; pfam00874 1217737009636 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737009637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737009638 active site 1217737009639 motif I; other site 1217737009640 motif II; other site 1217737009641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737009642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1217737009643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737009644 DNA-binding site [nucleotide binding]; DNA binding site 1217737009645 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1217737009646 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1217737009647 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1217737009648 active site 1217737009649 trimer interface [polypeptide binding]; other site 1217737009650 allosteric site; other site 1217737009651 active site lid [active] 1217737009652 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1217737009653 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1217737009654 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1217737009655 active site 1217737009656 dimer interface [polypeptide binding]; other site 1217737009657 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1217737009658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737009659 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1217737009660 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1217737009661 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1217737009662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737009663 Coenzyme A binding pocket [chemical binding]; other site 1217737009664 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1217737009665 active site 1217737009666 Predicted secreted protein [Function unknown]; Region: COG4086 1217737009667 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1217737009668 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737009669 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1217737009670 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1217737009671 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737009672 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1217737009673 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1217737009674 stage V sporulation protein AD; Validated; Region: PRK08304 1217737009675 stage V sporulation protein AD; Provisional; Region: PRK12404 1217737009676 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1217737009677 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1217737009678 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1217737009679 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1217737009680 Na2 binding site [ion binding]; other site 1217737009681 putative substrate binding site 1 [chemical binding]; other site 1217737009682 Na binding site 1 [ion binding]; other site 1217737009683 putative substrate binding site 2 [chemical binding]; other site 1217737009684 sporulation sigma factor SigF; Validated; Region: PRK05572 1217737009685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737009686 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1217737009687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737009688 DNA binding residues [nucleotide binding] 1217737009689 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1217737009690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737009691 ATP binding site [chemical binding]; other site 1217737009692 Mg2+ binding site [ion binding]; other site 1217737009693 G-X-G motif; other site 1217737009694 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1217737009695 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1217737009696 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737009697 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1217737009698 Predicted transcriptional regulators [Transcription]; Region: COG1725 1217737009699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737009700 DNA-binding site [nucleotide binding]; DNA binding site 1217737009701 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737009702 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737009703 Walker A/P-loop; other site 1217737009704 ATP binding site [chemical binding]; other site 1217737009705 Q-loop/lid; other site 1217737009706 ABC transporter signature motif; other site 1217737009707 Walker B; other site 1217737009708 D-loop; other site 1217737009709 H-loop/switch region; other site 1217737009710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737009711 MarR family; Region: MarR; pfam01047 1217737009712 MarR family; Region: MarR_2; cl17246 1217737009713 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1217737009714 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1217737009715 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1217737009716 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1217737009717 oligomer interface [polypeptide binding]; other site 1217737009718 metal binding site [ion binding]; metal-binding site 1217737009719 metal binding site [ion binding]; metal-binding site 1217737009720 putative Cl binding site [ion binding]; other site 1217737009721 aspartate ring; other site 1217737009722 basic sphincter; other site 1217737009723 hydrophobic gate; other site 1217737009724 periplasmic entrance; other site 1217737009725 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1217737009726 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1217737009727 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1217737009728 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1217737009729 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1217737009730 phosphopentomutase; Provisional; Region: PRK05362 1217737009731 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1217737009732 YtkA-like; Region: YtkA; pfam13115 1217737009733 YtkA-like; Region: YtkA; pfam13115 1217737009734 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1217737009735 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1217737009736 active site 1217737009737 Int/Topo IB signature motif; other site 1217737009738 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1217737009739 ferric uptake regulator; Provisional; Region: fur; PRK09462 1217737009740 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1217737009741 metal binding site 2 [ion binding]; metal-binding site 1217737009742 putative DNA binding helix; other site 1217737009743 metal binding site 1 [ion binding]; metal-binding site 1217737009744 dimer interface [polypeptide binding]; other site 1217737009745 structural Zn2+ binding site [ion binding]; other site 1217737009746 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1217737009747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737009748 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737009749 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1217737009750 dimer interface [polypeptide binding]; other site 1217737009751 ADP-ribose binding site [chemical binding]; other site 1217737009752 active site 1217737009753 nudix motif; other site 1217737009754 metal binding site [ion binding]; metal-binding site 1217737009755 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1217737009756 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737009757 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737009758 active site 1217737009759 catalytic tetrad [active] 1217737009760 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737009761 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737009762 active site 1217737009763 catalytic tetrad [active] 1217737009764 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1217737009765 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 1217737009766 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1217737009767 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1217737009768 putative active site [active] 1217737009769 putative metal binding site [ion binding]; other site 1217737009770 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1217737009771 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1217737009772 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737009773 Predicted permease [General function prediction only]; Region: COG2056 1217737009774 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1217737009775 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1217737009776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737009777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737009778 DNA binding site [nucleotide binding] 1217737009779 domain linker motif; other site 1217737009780 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1217737009781 dimerization interface [polypeptide binding]; other site 1217737009782 ligand binding site [chemical binding]; other site 1217737009783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737009784 Coenzyme A binding pocket [chemical binding]; other site 1217737009785 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1217737009786 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1217737009787 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1217737009788 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1217737009789 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1217737009790 catalytic motif [active] 1217737009791 Zn binding site [ion binding]; other site 1217737009792 RibD C-terminal domain; Region: RibD_C; cl17279 1217737009793 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1217737009794 Lumazine binding domain; Region: Lum_binding; pfam00677 1217737009795 Lumazine binding domain; Region: Lum_binding; pfam00677 1217737009796 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1217737009797 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1217737009798 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1217737009799 dimerization interface [polypeptide binding]; other site 1217737009800 active site 1217737009801 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1217737009802 homopentamer interface [polypeptide binding]; other site 1217737009803 active site 1217737009804 biotin synthase; Validated; Region: PRK06256 1217737009805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737009806 FeS/SAM binding site; other site 1217737009807 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1217737009808 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1217737009809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737009810 S-adenosylmethionine binding site [chemical binding]; other site 1217737009811 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1217737009812 Protein of unknown function (DUF452); Region: DUF452; cl01062 1217737009813 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1217737009814 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1217737009815 substrate-cofactor binding pocket; other site 1217737009816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737009817 catalytic residue [active] 1217737009818 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1217737009819 AAA domain; Region: AAA_26; pfam13500 1217737009820 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1217737009821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737009822 inhibitor-cofactor binding pocket; inhibition site 1217737009823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737009824 catalytic residue [active] 1217737009825 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1217737009826 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1217737009827 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 1217737009828 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1217737009829 active site 1217737009830 metal binding site [ion binding]; metal-binding site 1217737009831 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1217737009832 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1217737009833 active site 1217737009834 catalytic triad [active] 1217737009835 oxyanion hole [active] 1217737009836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737009837 dimerization interface [polypeptide binding]; other site 1217737009838 putative DNA binding site [nucleotide binding]; other site 1217737009839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737009840 putative Zn2+ binding site [ion binding]; other site 1217737009841 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1217737009842 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1217737009843 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1217737009844 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1217737009845 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1217737009846 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737009847 inhibitor-cofactor binding pocket; inhibition site 1217737009848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737009849 catalytic residue [active] 1217737009850 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1217737009851 nucleotide binding site [chemical binding]; other site 1217737009852 N-acetyl-L-glutamate binding site [chemical binding]; other site 1217737009853 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1217737009854 heterotetramer interface [polypeptide binding]; other site 1217737009855 active site pocket [active] 1217737009856 cleavage site 1217737009857 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1217737009858 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1217737009859 YqzH-like protein; Region: YqzH; pfam14164 1217737009860 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1217737009861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737009862 NAD(P) binding site [chemical binding]; other site 1217737009863 active site 1217737009864 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737009865 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 1217737009866 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1217737009867 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1217737009868 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1217737009869 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1217737009870 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1217737009871 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1217737009872 putative L-serine binding site [chemical binding]; other site 1217737009873 ribonuclease Z; Region: RNase_Z; TIGR02651 1217737009874 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 1217737009875 magnesium-transporting ATPase; Provisional; Region: PRK15122 1217737009876 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1217737009877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1217737009878 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1217737009879 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1217737009880 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1217737009881 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1217737009882 MgtC family; Region: MgtC; pfam02308 1217737009883 DNA polymerase IV; Validated; Region: PRK01810 1217737009884 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1217737009885 active site 1217737009886 DNA binding site [nucleotide binding] 1217737009887 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1217737009888 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1217737009889 peptidase T-like protein; Region: PepT-like; TIGR01883 1217737009890 metal binding site [ion binding]; metal-binding site 1217737009891 putative dimer interface [polypeptide binding]; other site 1217737009892 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737009893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737009894 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 1217737009895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1217737009896 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1217737009897 Predicted membrane protein [Function unknown]; Region: COG4129 1217737009898 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1217737009899 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1217737009900 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1217737009901 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1217737009902 Walker A/P-loop; other site 1217737009903 ATP binding site [chemical binding]; other site 1217737009904 Q-loop/lid; other site 1217737009905 ABC transporter signature motif; other site 1217737009906 Walker B; other site 1217737009907 D-loop; other site 1217737009908 H-loop/switch region; other site 1217737009909 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1217737009910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737009911 dimer interface [polypeptide binding]; other site 1217737009912 conserved gate region; other site 1217737009913 putative PBP binding loops; other site 1217737009914 ABC-ATPase subunit interface; other site 1217737009915 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1217737009916 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737009917 substrate binding pocket [chemical binding]; other site 1217737009918 membrane-bound complex binding site; other site 1217737009919 hinge residues; other site 1217737009920 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1217737009921 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1217737009922 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1217737009923 nudix motif; other site 1217737009924 Predicted membrane protein [Function unknown]; Region: COG2323 1217737009925 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1217737009926 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1217737009927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1217737009928 E3 interaction surface; other site 1217737009929 lipoyl attachment site [posttranslational modification]; other site 1217737009930 e3 binding domain; Region: E3_binding; pfam02817 1217737009931 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1217737009932 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1217737009933 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1217737009934 alpha subunit interface [polypeptide binding]; other site 1217737009935 TPP binding site [chemical binding]; other site 1217737009936 heterodimer interface [polypeptide binding]; other site 1217737009937 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1217737009938 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1217737009939 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1217737009940 tetramer interface [polypeptide binding]; other site 1217737009941 TPP-binding site [chemical binding]; other site 1217737009942 heterodimer interface [polypeptide binding]; other site 1217737009943 phosphorylation loop region [posttranslational modification] 1217737009944 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1217737009945 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1217737009946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737009947 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1217737009948 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1217737009949 nucleotide binding site [chemical binding]; other site 1217737009950 Acetokinase family; Region: Acetate_kinase; cl17229 1217737009951 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1217737009952 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1217737009953 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1217737009954 NAD binding site [chemical binding]; other site 1217737009955 Phe binding site; other site 1217737009956 phosphate butyryltransferase; Validated; Region: PRK07742 1217737009957 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1217737009958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737009959 putative active site [active] 1217737009960 heme pocket [chemical binding]; other site 1217737009961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737009962 putative active site [active] 1217737009963 heme pocket [chemical binding]; other site 1217737009964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737009965 Walker A motif; other site 1217737009966 ATP binding site [chemical binding]; other site 1217737009967 Walker B motif; other site 1217737009968 arginine finger; other site 1217737009969 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1217737009970 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1217737009971 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1217737009972 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1217737009973 active site 1217737009974 catalytic site [active] 1217737009975 metal binding site [ion binding]; metal-binding site 1217737009976 dimer interface [polypeptide binding]; other site 1217737009977 YycC-like protein; Region: YycC; pfam14174 1217737009978 hypothetical protein; Provisional; Region: PRK06770 1217737009979 Divergent AAA domain; Region: AAA_4; pfam04326 1217737009980 putative transposase OrfB; Reviewed; Region: PHA02517 1217737009981 HTH-like domain; Region: HTH_21; pfam13276 1217737009982 Integrase core domain; Region: rve; pfam00665 1217737009983 Integrase core domain; Region: rve_2; pfam13333 1217737009984 Homeodomain-like domain; Region: HTH_23; cl17451 1217737009985 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737009986 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737009987 catalytic residues [active] 1217737009988 catalytic nucleophile [active] 1217737009989 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737009990 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737009991 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737009992 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737009993 DNA binding site [nucleotide binding] 1217737009994 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1217737009995 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 1217737009996 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1217737009997 DNA-binding interface [nucleotide binding]; DNA binding site 1217737009998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737009999 non-specific DNA binding site [nucleotide binding]; other site 1217737010000 salt bridge; other site 1217737010001 sequence-specific DNA binding site [nucleotide binding]; other site 1217737010002 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1217737010003 DNA binding residues [nucleotide binding] 1217737010004 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1217737010005 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737010006 active site 1217737010007 Int/Topo IB signature motif; other site 1217737010008 DNA binding site [nucleotide binding] 1217737010009 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1217737010010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737010011 active site 1217737010012 phosphorylation site [posttranslational modification] 1217737010013 intermolecular recognition site; other site 1217737010014 dimerization interface [polypeptide binding]; other site 1217737010015 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1217737010016 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1217737010017 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1217737010018 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1217737010019 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1217737010020 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1217737010021 Walker A/P-loop; other site 1217737010022 ATP binding site [chemical binding]; other site 1217737010023 Q-loop/lid; other site 1217737010024 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1217737010025 ABC transporter signature motif; other site 1217737010026 Walker B; other site 1217737010027 D-loop; other site 1217737010028 H-loop/switch region; other site 1217737010029 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1217737010030 arginine repressor; Provisional; Region: PRK04280 1217737010031 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1217737010032 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1217737010033 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737010034 RNA binding surface [nucleotide binding]; other site 1217737010035 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1217737010036 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1217737010037 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1217737010038 TPP-binding site; other site 1217737010039 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1217737010040 PYR/PP interface [polypeptide binding]; other site 1217737010041 dimer interface [polypeptide binding]; other site 1217737010042 TPP binding site [chemical binding]; other site 1217737010043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1217737010044 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1217737010045 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1217737010046 substrate binding pocket [chemical binding]; other site 1217737010047 chain length determination region; other site 1217737010048 substrate-Mg2+ binding site; other site 1217737010049 catalytic residues [active] 1217737010050 aspartate-rich region 1; other site 1217737010051 active site lid residues [active] 1217737010052 aspartate-rich region 2; other site 1217737010053 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1217737010054 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1217737010055 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1217737010056 generic binding surface II; other site 1217737010057 generic binding surface I; other site 1217737010058 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1217737010059 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1217737010060 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1217737010061 homodimer interface [polypeptide binding]; other site 1217737010062 NADP binding site [chemical binding]; other site 1217737010063 substrate binding site [chemical binding]; other site 1217737010064 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1217737010065 putative RNA binding site [nucleotide binding]; other site 1217737010066 Asp23 family; Region: Asp23; pfam03780 1217737010067 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1217737010068 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1217737010069 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1217737010070 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1217737010071 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1217737010072 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1217737010073 carboxyltransferase (CT) interaction site; other site 1217737010074 biotinylation site [posttranslational modification]; other site 1217737010075 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1217737010076 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1217737010077 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1217737010078 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1217737010079 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1217737010080 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1217737010081 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1217737010082 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1217737010083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737010084 Walker A motif; other site 1217737010085 ATP binding site [chemical binding]; other site 1217737010086 Walker B motif; other site 1217737010087 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1217737010088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737010089 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737010090 elongation factor P; Validated; Region: PRK00529 1217737010091 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1217737010092 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1217737010093 RNA binding site [nucleotide binding]; other site 1217737010094 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1217737010095 RNA binding site [nucleotide binding]; other site 1217737010096 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1217737010097 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1217737010098 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1217737010099 active site 1217737010100 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1217737010101 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1217737010102 trimer interface [polypeptide binding]; other site 1217737010103 active site 1217737010104 dimer interface [polypeptide binding]; other site 1217737010105 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1217737010106 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1217737010107 Carbon starvation protein CstA; Region: CstA; pfam02554 1217737010108 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1217737010109 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1217737010110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737010111 motif II; other site 1217737010112 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1217737010113 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1217737010114 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1217737010115 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1217737010116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737010117 FeS/SAM binding site; other site 1217737010118 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737010119 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737010120 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1217737010121 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737010122 active site residue [active] 1217737010123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737010124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737010125 DNA binding site [nucleotide binding] 1217737010126 domain linker motif; other site 1217737010127 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1217737010128 putative dimerization interface [polypeptide binding]; other site 1217737010129 putative ligand binding site [chemical binding]; other site 1217737010130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737010131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737010132 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737010133 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737010134 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 1217737010135 Domain of unknown function (DUF202); Region: DUF202; cl09954 1217737010136 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 1217737010137 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1217737010138 tetramer interface [polypeptide binding]; other site 1217737010139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010140 catalytic residue [active] 1217737010141 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1217737010142 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1217737010143 tetramer interface [polypeptide binding]; other site 1217737010144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010145 catalytic residue [active] 1217737010146 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1217737010147 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1217737010148 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1217737010149 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1217737010150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737010151 ATP binding site [chemical binding]; other site 1217737010152 putative Mg++ binding site [ion binding]; other site 1217737010153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737010154 nucleotide binding region [chemical binding]; other site 1217737010155 ATP-binding site [chemical binding]; other site 1217737010156 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1217737010157 YqzE-like protein; Region: YqzE; pfam14038 1217737010158 shikimate kinase; Reviewed; Region: aroK; PRK00131 1217737010159 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1217737010160 ADP binding site [chemical binding]; other site 1217737010161 magnesium binding site [ion binding]; other site 1217737010162 putative shikimate binding site; other site 1217737010163 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1217737010164 ComG operon protein 7; Region: ComGG; pfam14173 1217737010165 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1217737010166 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1217737010167 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1217737010168 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1217737010169 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1217737010170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1217737010171 Type II/IV secretion system protein; Region: T2SE; pfam00437 1217737010172 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1217737010173 Walker A motif; other site 1217737010174 ATP binding site [chemical binding]; other site 1217737010175 Walker B motif; other site 1217737010176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737010177 putative DNA binding site [nucleotide binding]; other site 1217737010178 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1217737010179 putative Zn2+ binding site [ion binding]; other site 1217737010180 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1217737010181 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1217737010182 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1217737010183 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 1217737010184 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1217737010185 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1217737010186 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 1217737010187 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1217737010188 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1217737010189 active site 1217737010190 homodimer interface [polypeptide binding]; other site 1217737010191 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1217737010192 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1217737010193 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1217737010194 substrate binding pocket [chemical binding]; other site 1217737010195 dimer interface [polypeptide binding]; other site 1217737010196 inhibitor binding site; inhibition site 1217737010197 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1217737010198 B12 binding site [chemical binding]; other site 1217737010199 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1217737010200 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1217737010201 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1217737010202 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1217737010203 FAD binding site [chemical binding]; other site 1217737010204 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1217737010205 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1217737010206 homodimer interface [polypeptide binding]; other site 1217737010207 substrate-cofactor binding pocket; other site 1217737010208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010209 catalytic residue [active] 1217737010210 cystathionine beta-lyase; Provisional; Region: PRK08064 1217737010211 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1217737010212 homodimer interface [polypeptide binding]; other site 1217737010213 substrate-cofactor binding pocket; other site 1217737010214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010215 catalytic residue [active] 1217737010216 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737010217 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1217737010218 catalytic triad [active] 1217737010219 conserved cis-peptide bond; other site 1217737010220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737010221 dimerization interface [polypeptide binding]; other site 1217737010222 putative DNA binding site [nucleotide binding]; other site 1217737010223 putative Zn2+ binding site [ion binding]; other site 1217737010224 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1217737010225 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1217737010226 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1217737010227 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1217737010228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1217737010229 nucleotide binding site [chemical binding]; other site 1217737010230 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1217737010231 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1217737010232 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1217737010233 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1217737010234 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1217737010235 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1217737010236 active site 1217737010237 Substrate binding site; other site 1217737010238 Mg++ binding site; other site 1217737010239 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1217737010240 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1217737010241 active site 1217737010242 metal binding site [ion binding]; metal-binding site 1217737010243 substrate binding site [chemical binding]; other site 1217737010244 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1217737010245 PhoU domain; Region: PhoU; pfam01895 1217737010246 PhoU domain; Region: PhoU; pfam01895 1217737010247 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1217737010248 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1217737010249 Walker A/P-loop; other site 1217737010250 ATP binding site [chemical binding]; other site 1217737010251 Q-loop/lid; other site 1217737010252 ABC transporter signature motif; other site 1217737010253 Walker B; other site 1217737010254 D-loop; other site 1217737010255 H-loop/switch region; other site 1217737010256 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1217737010257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737010258 dimer interface [polypeptide binding]; other site 1217737010259 conserved gate region; other site 1217737010260 putative PBP binding loops; other site 1217737010261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1217737010262 ABC-ATPase subunit interface; other site 1217737010263 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1217737010264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737010265 dimer interface [polypeptide binding]; other site 1217737010266 conserved gate region; other site 1217737010267 putative PBP binding loops; other site 1217737010268 ABC-ATPase subunit interface; other site 1217737010269 PBP superfamily domain; Region: PBP_like_2; cl17296 1217737010270 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737010271 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737010272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737010273 Helix-turn-helix domain; Region: HTH_36; pfam13730 1217737010274 Replication-relaxation; Region: Replic_Relax; pfam13814 1217737010275 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737010276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737010277 non-specific DNA binding site [nucleotide binding]; other site 1217737010278 sequence-specific DNA binding site [nucleotide binding]; other site 1217737010279 salt bridge; other site 1217737010280 Restriction endonuclease; Region: Mrr_cat; pfam04471 1217737010281 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1217737010282 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737010283 amidase catalytic site [active] 1217737010284 Zn binding residues [ion binding]; other site 1217737010285 substrate binding site [chemical binding]; other site 1217737010286 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737010287 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1217737010288 Haemolysin XhlA; Region: XhlA; pfam10779 1217737010289 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1217737010290 H-type lectin domain; Region: H_lectin; pfam09458 1217737010291 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737010292 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737010293 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737010294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1217737010295 Terminase-like family; Region: Terminase_6; pfam03237 1217737010296 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1217737010297 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737010298 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737010299 catalytic residues [active] 1217737010300 catalytic nucleophile [active] 1217737010301 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737010302 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737010303 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737010304 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737010305 DNA binding site [nucleotide binding] 1217737010306 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1217737010307 DNA-binding interface [nucleotide binding]; DNA binding site 1217737010308 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1217737010309 D5 N terminal like; Region: D5_N; smart00885 1217737010310 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1217737010311 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1217737010312 active site 1217737010313 substrate binding site [chemical binding]; other site 1217737010314 catalytic site [active] 1217737010315 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 1217737010316 active site 1217737010317 metal-binding site 1217737010318 Protein of unknown function (DUF669); Region: DUF669; pfam05037 1217737010319 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1217737010320 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 1217737010321 AAA domain; Region: AAA_24; pfam13479 1217737010322 VRR-NUC domain; Region: VRR_NUC; pfam08774 1217737010323 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1217737010324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737010325 nucleotide binding region [chemical binding]; other site 1217737010326 ATP-binding site [chemical binding]; other site 1217737010327 RNA polymerase factor sigma-70; Validated; Region: PRK06759 1217737010328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737010329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737010330 DNA binding residues [nucleotide binding] 1217737010331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737010332 non-specific DNA binding site [nucleotide binding]; other site 1217737010333 salt bridge; other site 1217737010334 sequence-specific DNA binding site [nucleotide binding]; other site 1217737010335 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737010336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737010337 non-specific DNA binding site [nucleotide binding]; other site 1217737010338 salt bridge; other site 1217737010339 sequence-specific DNA binding site [nucleotide binding]; other site 1217737010340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737010341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737010342 non-specific DNA binding site [nucleotide binding]; other site 1217737010343 salt bridge; other site 1217737010344 sequence-specific DNA binding site [nucleotide binding]; other site 1217737010345 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1217737010346 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1217737010347 Int/Topo IB signature motif; other site 1217737010348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737010349 putative substrate translocation pore; other site 1217737010350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737010351 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1217737010352 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1217737010353 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1217737010354 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1217737010355 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1217737010356 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1217737010357 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1217737010358 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1217737010359 metal binding site 2 [ion binding]; metal-binding site 1217737010360 putative DNA binding helix; other site 1217737010361 metal binding site 1 [ion binding]; metal-binding site 1217737010362 dimer interface [polypeptide binding]; other site 1217737010363 structural Zn2+ binding site [ion binding]; other site 1217737010364 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1217737010365 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737010366 ABC-ATPase subunit interface; other site 1217737010367 dimer interface [polypeptide binding]; other site 1217737010368 putative PBP binding regions; other site 1217737010369 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1217737010370 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1217737010371 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737010372 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737010373 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737010374 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1217737010375 endonuclease IV; Provisional; Region: PRK01060 1217737010376 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1217737010377 AP (apurinic/apyrimidinic) site pocket; other site 1217737010378 DNA interaction; other site 1217737010379 Metal-binding active site; metal-binding site 1217737010380 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1217737010381 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1217737010382 ATP binding site [chemical binding]; other site 1217737010383 Mg++ binding site [ion binding]; other site 1217737010384 motif III; other site 1217737010385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737010386 nucleotide binding region [chemical binding]; other site 1217737010387 ATP-binding site [chemical binding]; other site 1217737010388 YqfQ-like protein; Region: YqfQ; pfam14181 1217737010389 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1217737010390 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1217737010391 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1217737010392 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1217737010393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1217737010394 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1217737010395 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1217737010396 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1217737010397 Family of unknown function (DUF633); Region: DUF633; pfam04816 1217737010398 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1217737010399 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1217737010400 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1217737010401 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1217737010402 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1217737010403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737010404 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1217737010405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737010406 DNA binding residues [nucleotide binding] 1217737010407 DNA primase; Validated; Region: dnaG; PRK05667 1217737010408 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1217737010409 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1217737010410 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1217737010411 active site 1217737010412 metal binding site [ion binding]; metal-binding site 1217737010413 interdomain interaction site; other site 1217737010414 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1217737010415 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1217737010416 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1217737010417 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1217737010418 HTH domain; Region: HTH_11; pfam08279 1217737010419 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1217737010420 FOG: CBS domain [General function prediction only]; Region: COG0517 1217737010421 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1217737010422 Recombination protein O N terminal; Region: RecO_N; pfam11967 1217737010423 Recombination protein O C terminal; Region: RecO_C; pfam02565 1217737010424 YqzL-like protein; Region: YqzL; pfam14006 1217737010425 GTPase Era; Reviewed; Region: era; PRK00089 1217737010426 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1217737010427 G1 box; other site 1217737010428 GTP/Mg2+ binding site [chemical binding]; other site 1217737010429 Switch I region; other site 1217737010430 G2 box; other site 1217737010431 Switch II region; other site 1217737010432 G3 box; other site 1217737010433 G4 box; other site 1217737010434 G5 box; other site 1217737010435 KH domain; Region: KH_2; pfam07650 1217737010436 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1217737010437 active site 1217737010438 catalytic motif [active] 1217737010439 Zn binding site [ion binding]; other site 1217737010440 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1217737010441 metal-binding heat shock protein; Provisional; Region: PRK00016 1217737010442 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1217737010443 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1217737010444 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737010445 Zn2+ binding site [ion binding]; other site 1217737010446 Mg2+ binding site [ion binding]; other site 1217737010447 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1217737010448 PhoH-like protein; Region: PhoH; pfam02562 1217737010449 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1217737010450 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1217737010451 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1217737010452 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1217737010453 Yqey-like protein; Region: YqeY; pfam09424 1217737010454 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1217737010455 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1217737010456 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1217737010457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737010458 FeS/SAM binding site; other site 1217737010459 TRAM domain; Region: TRAM; cl01282 1217737010460 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1217737010461 RNA methyltransferase, RsmE family; Region: TIGR00046 1217737010462 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1217737010463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737010464 S-adenosylmethionine binding site [chemical binding]; other site 1217737010465 chaperone protein DnaJ; Provisional; Region: PRK14280 1217737010466 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1217737010467 HSP70 interaction site [polypeptide binding]; other site 1217737010468 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1217737010469 substrate binding site [polypeptide binding]; other site 1217737010470 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1217737010471 Zn binding sites [ion binding]; other site 1217737010472 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1217737010473 dimer interface [polypeptide binding]; other site 1217737010474 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1217737010475 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1217737010476 nucleotide binding site [chemical binding]; other site 1217737010477 NEF interaction site [polypeptide binding]; other site 1217737010478 SBD interface [polypeptide binding]; other site 1217737010479 GrpE; Region: GrpE; pfam01025 1217737010480 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1217737010481 dimer interface [polypeptide binding]; other site 1217737010482 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1217737010483 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1217737010484 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1217737010485 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1217737010486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737010487 FeS/SAM binding site; other site 1217737010488 HemN C-terminal domain; Region: HemN_C; pfam06969 1217737010489 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737010490 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1217737010491 GTP-binding protein LepA; Provisional; Region: PRK05433 1217737010492 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1217737010493 G1 box; other site 1217737010494 putative GEF interaction site [polypeptide binding]; other site 1217737010495 GTP/Mg2+ binding site [chemical binding]; other site 1217737010496 Switch I region; other site 1217737010497 G2 box; other site 1217737010498 G3 box; other site 1217737010499 Switch II region; other site 1217737010500 G4 box; other site 1217737010501 G5 box; other site 1217737010502 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1217737010503 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1217737010504 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1217737010505 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1217737010506 germination protease; Provisional; Region: PRK02858 1217737010507 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1217737010508 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1217737010509 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1217737010510 YqzM-like protein; Region: YqzM; pfam14141 1217737010511 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1217737010512 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1217737010513 Competence protein; Region: Competence; pfam03772 1217737010514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737010515 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1217737010516 catalytic motif [active] 1217737010517 Zn binding site [ion binding]; other site 1217737010518 SLBB domain; Region: SLBB; pfam10531 1217737010519 comEA protein; Region: comE; TIGR01259 1217737010520 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1217737010521 late competence protein ComER; Validated; Region: PRK07680 1217737010522 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1217737010523 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1217737010524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737010525 S-adenosylmethionine binding site [chemical binding]; other site 1217737010526 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 1217737010527 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1217737010528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737010529 Zn2+ binding site [ion binding]; other site 1217737010530 Mg2+ binding site [ion binding]; other site 1217737010531 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1217737010532 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1217737010533 active site 1217737010534 (T/H)XGH motif; other site 1217737010535 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1217737010536 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1217737010537 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1217737010538 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1217737010539 shikimate binding site; other site 1217737010540 NAD(P) binding site [chemical binding]; other site 1217737010541 GTPase YqeH; Provisional; Region: PRK13796 1217737010542 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1217737010543 GTP/Mg2+ binding site [chemical binding]; other site 1217737010544 G4 box; other site 1217737010545 G5 box; other site 1217737010546 G1 box; other site 1217737010547 Switch I region; other site 1217737010548 G2 box; other site 1217737010549 G3 box; other site 1217737010550 Switch II region; other site 1217737010551 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1217737010552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737010553 active site 1217737010554 motif I; other site 1217737010555 motif II; other site 1217737010556 Sporulation inhibitor A; Region: Sda; pfam08970 1217737010557 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1217737010558 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1217737010559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737010560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737010561 DNA binding residues [nucleotide binding] 1217737010562 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1217737010563 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1217737010564 dimer interface [polypeptide binding]; other site 1217737010565 FMN binding site [chemical binding]; other site 1217737010566 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1217737010567 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1217737010568 synthetase active site [active] 1217737010569 NTP binding site [chemical binding]; other site 1217737010570 metal binding site [ion binding]; metal-binding site 1217737010571 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1217737010572 dimer interface [polypeptide binding]; other site 1217737010573 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1217737010574 active site 1217737010575 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1217737010576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737010577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737010578 Coenzyme A binding pocket [chemical binding]; other site 1217737010579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737010580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737010581 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1217737010582 catalytic site [active] 1217737010583 DoxX; Region: DoxX; cl17842 1217737010584 CHAT domain; Region: CHAT; cl17868 1217737010585 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1217737010586 catalytic core [active] 1217737010587 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1217737010588 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1217737010589 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1217737010590 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1217737010591 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1217737010592 putative active site [active] 1217737010593 catalytic triad [active] 1217737010594 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1217737010595 putative integrin binding motif; other site 1217737010596 PA/protease domain interface [polypeptide binding]; other site 1217737010597 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1217737010598 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1217737010599 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1217737010600 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1217737010601 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1217737010602 cofactor binding site; other site 1217737010603 metal binding site [ion binding]; metal-binding site 1217737010604 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1217737010605 aromatic arch; other site 1217737010606 DCoH dimer interaction site [polypeptide binding]; other site 1217737010607 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1217737010608 DCoH tetramer interaction site [polypeptide binding]; other site 1217737010609 substrate binding site [chemical binding]; other site 1217737010610 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1217737010611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1217737010612 putative metal binding site [ion binding]; other site 1217737010613 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1217737010614 active site 1217737010615 metal binding site [ion binding]; metal-binding site 1217737010616 Predicted membrane protein [Function unknown]; Region: COG2259 1217737010617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737010618 non-specific DNA binding site [nucleotide binding]; other site 1217737010619 salt bridge; other site 1217737010620 sequence-specific DNA binding site [nucleotide binding]; other site 1217737010621 Cupin domain; Region: Cupin_2; pfam07883 1217737010622 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1217737010623 active site 2 [active] 1217737010624 active site 1 [active] 1217737010625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737010626 Coenzyme A binding pocket [chemical binding]; other site 1217737010627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737010628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1217737010629 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1217737010630 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1217737010631 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1217737010632 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1217737010633 Walker A/P-loop; other site 1217737010634 ATP binding site [chemical binding]; other site 1217737010635 Q-loop/lid; other site 1217737010636 ABC transporter signature motif; other site 1217737010637 Walker B; other site 1217737010638 D-loop; other site 1217737010639 H-loop/switch region; other site 1217737010640 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1217737010641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737010642 ABC-ATPase subunit interface; other site 1217737010643 dimer interface [polypeptide binding]; other site 1217737010644 putative PBP binding regions; other site 1217737010645 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1217737010646 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1217737010647 intersubunit interface [polypeptide binding]; other site 1217737010648 YrhC-like protein; Region: YrhC; pfam14143 1217737010649 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1217737010650 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1217737010651 putative catalytic cysteine [active] 1217737010652 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1217737010653 putative active site [active] 1217737010654 metal binding site [ion binding]; metal-binding site 1217737010655 cystathionine beta-lyase; Provisional; Region: PRK07671 1217737010656 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1217737010657 homodimer interface [polypeptide binding]; other site 1217737010658 substrate-cofactor binding pocket; other site 1217737010659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010660 catalytic residue [active] 1217737010661 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1217737010662 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1217737010663 dimer interface [polypeptide binding]; other site 1217737010664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010665 catalytic residue [active] 1217737010666 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1217737010667 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1217737010668 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1217737010669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737010670 S-adenosylmethionine binding site [chemical binding]; other site 1217737010671 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1217737010672 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1217737010673 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1217737010674 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1217737010675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737010676 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 1217737010677 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1217737010678 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1217737010679 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1217737010680 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1217737010681 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1217737010682 ATP-binding site [chemical binding]; other site 1217737010683 Sugar specificity; other site 1217737010684 Pyrimidine base specificity; other site 1217737010685 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1217737010686 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1217737010687 Peptidase family U32; Region: Peptidase_U32; pfam01136 1217737010688 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1217737010689 Protein of unknown function (DUF556); Region: DUF556; cl00822 1217737010690 Peptidase family U32; Region: Peptidase_U32; pfam01136 1217737010691 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1217737010692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737010693 S-adenosylmethionine binding site [chemical binding]; other site 1217737010694 YceG-like family; Region: YceG; pfam02618 1217737010695 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1217737010696 dimerization interface [polypeptide binding]; other site 1217737010697 hypothetical protein; Provisional; Region: PRK13678 1217737010698 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1217737010699 hypothetical protein; Provisional; Region: PRK05473 1217737010700 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1217737010701 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1217737010702 motif 1; other site 1217737010703 active site 1217737010704 motif 2; other site 1217737010705 motif 3; other site 1217737010706 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1217737010707 DHHA1 domain; Region: DHHA1; pfam02272 1217737010708 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1217737010709 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1217737010710 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1217737010711 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1217737010712 AAA domain; Region: AAA_30; pfam13604 1217737010713 Family description; Region: UvrD_C_2; pfam13538 1217737010714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737010715 TPR motif; other site 1217737010716 TPR repeat; Region: TPR_11; pfam13414 1217737010717 binding surface 1217737010718 TPR repeat; Region: TPR_11; pfam13414 1217737010719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737010720 binding surface 1217737010721 TPR motif; other site 1217737010722 TPR repeat; Region: TPR_11; pfam13414 1217737010723 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1217737010724 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1217737010725 Ligand Binding Site [chemical binding]; other site 1217737010726 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1217737010727 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1217737010728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737010729 catalytic residue [active] 1217737010730 Predicted transcriptional regulator [Transcription]; Region: COG1959 1217737010731 Transcriptional regulator; Region: Rrf2; pfam02082 1217737010732 recombination factor protein RarA; Reviewed; Region: PRK13342 1217737010733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737010734 Walker A motif; other site 1217737010735 ATP binding site [chemical binding]; other site 1217737010736 Walker B motif; other site 1217737010737 arginine finger; other site 1217737010738 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1217737010739 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1217737010740 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1217737010741 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1217737010742 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1217737010743 putative ATP binding site [chemical binding]; other site 1217737010744 putative substrate interface [chemical binding]; other site 1217737010745 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1217737010746 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1217737010747 dimer interface [polypeptide binding]; other site 1217737010748 anticodon binding site; other site 1217737010749 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1217737010750 homodimer interface [polypeptide binding]; other site 1217737010751 motif 1; other site 1217737010752 active site 1217737010753 motif 2; other site 1217737010754 GAD domain; Region: GAD; pfam02938 1217737010755 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1217737010756 motif 3; other site 1217737010757 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1217737010758 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1217737010759 dimer interface [polypeptide binding]; other site 1217737010760 motif 1; other site 1217737010761 active site 1217737010762 motif 2; other site 1217737010763 motif 3; other site 1217737010764 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1217737010765 anticodon binding site; other site 1217737010766 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1217737010767 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1217737010768 putative active site [active] 1217737010769 dimerization interface [polypeptide binding]; other site 1217737010770 putative tRNAtyr binding site [nucleotide binding]; other site 1217737010771 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1217737010772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737010773 Zn2+ binding site [ion binding]; other site 1217737010774 Mg2+ binding site [ion binding]; other site 1217737010775 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1217737010776 synthetase active site [active] 1217737010777 NTP binding site [chemical binding]; other site 1217737010778 metal binding site [ion binding]; metal-binding site 1217737010779 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1217737010780 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1217737010781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737010782 active site 1217737010783 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1217737010784 DHH family; Region: DHH; pfam01368 1217737010785 DHHA1 domain; Region: DHHA1; pfam02272 1217737010786 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1217737010787 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1217737010788 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1217737010789 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1217737010790 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1217737010791 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1217737010792 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1217737010793 Protein export membrane protein; Region: SecD_SecF; pfam02355 1217737010794 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1217737010795 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1217737010796 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1217737010797 Predicted membrane protein [Function unknown]; Region: COG2323 1217737010798 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1217737010799 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1217737010800 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1217737010801 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1217737010802 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1217737010803 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1217737010804 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1217737010805 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1217737010806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737010807 Walker A motif; other site 1217737010808 ATP binding site [chemical binding]; other site 1217737010809 Walker B motif; other site 1217737010810 arginine finger; other site 1217737010811 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1217737010812 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1217737010813 RuvA N terminal domain; Region: RuvA_N; pfam01330 1217737010814 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1217737010815 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1217737010816 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1217737010817 putative ligand binding residues [chemical binding]; other site 1217737010818 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1217737010819 BofC C-terminal domain; Region: BofC_C; pfam08955 1217737010820 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1217737010821 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737010822 quinolinate synthetase; Provisional; Region: PRK09375 1217737010823 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1217737010824 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1217737010825 dimerization interface [polypeptide binding]; other site 1217737010826 active site 1217737010827 L-aspartate oxidase; Provisional; Region: PRK08071 1217737010828 L-aspartate oxidase; Provisional; Region: PRK06175 1217737010829 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1217737010830 cysteine desulfurase; Provisional; Region: PRK02948 1217737010831 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1217737010832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737010833 catalytic residue [active] 1217737010834 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1217737010835 HTH domain; Region: HTH_11; pfam08279 1217737010836 3H domain; Region: 3H; pfam02829 1217737010837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1217737010838 MOSC domain; Region: MOSC; pfam03473 1217737010839 3-alpha domain; Region: 3-alpha; pfam03475 1217737010840 prephenate dehydratase; Provisional; Region: PRK11898 1217737010841 Prephenate dehydratase; Region: PDT; pfam00800 1217737010842 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1217737010843 putative L-Phe binding site [chemical binding]; other site 1217737010844 FtsX-like permease family; Region: FtsX; pfam02687 1217737010845 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737010846 FtsX-like permease family; Region: FtsX; pfam02687 1217737010847 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737010848 FtsX-like permease family; Region: FtsX; pfam02687 1217737010849 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737010850 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737010851 Walker A/P-loop; other site 1217737010852 ATP binding site [chemical binding]; other site 1217737010853 Q-loop/lid; other site 1217737010854 ABC transporter signature motif; other site 1217737010855 Walker B; other site 1217737010856 D-loop; other site 1217737010857 H-loop/switch region; other site 1217737010858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737010859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1217737010860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737010861 ATP binding site [chemical binding]; other site 1217737010862 Mg2+ binding site [ion binding]; other site 1217737010863 G-X-G motif; other site 1217737010864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737010865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737010866 active site 1217737010867 phosphorylation site [posttranslational modification] 1217737010868 intermolecular recognition site; other site 1217737010869 dimerization interface [polypeptide binding]; other site 1217737010870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737010871 DNA binding site [nucleotide binding] 1217737010872 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1217737010873 GTP1/OBG; Region: GTP1_OBG; pfam01018 1217737010874 Obg GTPase; Region: Obg; cd01898 1217737010875 G1 box; other site 1217737010876 GTP/Mg2+ binding site [chemical binding]; other site 1217737010877 Switch I region; other site 1217737010878 G2 box; other site 1217737010879 G3 box; other site 1217737010880 Switch II region; other site 1217737010881 G4 box; other site 1217737010882 G5 box; other site 1217737010883 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1217737010884 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1217737010885 hypothetical protein; Provisional; Region: PRK14553 1217737010886 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1217737010887 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1217737010888 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1217737010889 homodimer interface [polypeptide binding]; other site 1217737010890 oligonucleotide binding site [chemical binding]; other site 1217737010891 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1217737010892 Peptidase family M50; Region: Peptidase_M50; pfam02163 1217737010893 active site 1217737010894 putative substrate binding region [chemical binding]; other site 1217737010895 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737010896 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737010897 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1217737010898 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1217737010899 Switch I; other site 1217737010900 Switch II; other site 1217737010901 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1217737010902 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1217737010903 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1217737010904 rod shape-determining protein MreC; Provisional; Region: PRK13922 1217737010905 rod shape-determining protein MreC; Region: MreC; pfam04085 1217737010906 rod shape-determining protein MreB; Provisional; Region: PRK13927 1217737010907 MreB and similar proteins; Region: MreB_like; cd10225 1217737010908 nucleotide binding site [chemical binding]; other site 1217737010909 Mg binding site [ion binding]; other site 1217737010910 putative protofilament interaction site [polypeptide binding]; other site 1217737010911 RodZ interaction site [polypeptide binding]; other site 1217737010912 hypothetical protein; Reviewed; Region: PRK00024 1217737010913 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1217737010914 MPN+ (JAMM) motif; other site 1217737010915 Zinc-binding site [ion binding]; other site 1217737010916 Maf-like protein; Region: Maf; pfam02545 1217737010917 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1217737010918 active site 1217737010919 dimer interface [polypeptide binding]; other site 1217737010920 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1217737010921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1217737010922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1217737010923 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1217737010924 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1217737010925 active site 1217737010926 HIGH motif; other site 1217737010927 nucleotide binding site [chemical binding]; other site 1217737010928 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1217737010929 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1217737010930 active site 1217737010931 KMSKS motif; other site 1217737010932 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1217737010933 tRNA binding surface [nucleotide binding]; other site 1217737010934 anticodon binding site; other site 1217737010935 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1217737010936 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1217737010937 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1217737010938 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1217737010939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737010940 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1217737010941 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737010942 inhibitor-cofactor binding pocket; inhibition site 1217737010943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737010944 catalytic residue [active] 1217737010945 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1217737010946 dimer interface [polypeptide binding]; other site 1217737010947 active site 1217737010948 Schiff base residues; other site 1217737010949 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1217737010950 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1217737010951 active site 1217737010952 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1217737010953 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1217737010954 domain interfaces; other site 1217737010955 active site 1217737010956 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1217737010957 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1217737010958 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1217737010959 tRNA; other site 1217737010960 putative tRNA binding site [nucleotide binding]; other site 1217737010961 putative NADP binding site [chemical binding]; other site 1217737010962 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1217737010963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1217737010964 MarR family; Region: MarR; pfam01047 1217737010965 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1217737010966 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1217737010967 G1 box; other site 1217737010968 GTP/Mg2+ binding site [chemical binding]; other site 1217737010969 Switch I region; other site 1217737010970 G2 box; other site 1217737010971 G3 box; other site 1217737010972 Switch II region; other site 1217737010973 G4 box; other site 1217737010974 G5 box; other site 1217737010975 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1217737010976 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1217737010977 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1217737010978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737010979 Walker A motif; other site 1217737010980 ATP binding site [chemical binding]; other site 1217737010981 Walker B motif; other site 1217737010982 arginine finger; other site 1217737010983 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1217737010984 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1217737010985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737010986 Walker A motif; other site 1217737010987 ATP binding site [chemical binding]; other site 1217737010988 Walker B motif; other site 1217737010989 arginine finger; other site 1217737010990 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1217737010991 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1217737010992 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1217737010993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737010994 Walker A motif; other site 1217737010995 ATP binding site [chemical binding]; other site 1217737010996 Walker B motif; other site 1217737010997 arginine finger; other site 1217737010998 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1217737010999 trigger factor; Provisional; Region: tig; PRK01490 1217737011000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1217737011001 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1217737011002 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1217737011003 pentamer interface [polypeptide binding]; other site 1217737011004 dodecaamer interface [polypeptide binding]; other site 1217737011005 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1217737011006 Homeodomain-like domain; Region: HTH_23; cl17451 1217737011007 putative transposase OrfB; Reviewed; Region: PHA02517 1217737011008 HTH-like domain; Region: HTH_21; pfam13276 1217737011009 Integrase core domain; Region: rve; pfam00665 1217737011010 Integrase core domain; Region: rve_2; pfam13333 1217737011011 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1217737011012 active site 1217737011013 metal binding site [ion binding]; metal-binding site 1217737011014 homotetramer interface [polypeptide binding]; other site 1217737011015 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1217737011016 active site 1217737011017 dimerization interface [polypeptide binding]; other site 1217737011018 ribonuclease PH; Reviewed; Region: rph; PRK00173 1217737011019 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1217737011020 hexamer interface [polypeptide binding]; other site 1217737011021 active site 1217737011022 Sporulation and spore germination; Region: Germane; pfam10646 1217737011023 Spore germination protein [General function prediction only]; Region: COG5401 1217737011024 Sporulation and spore germination; Region: Germane; pfam10646 1217737011025 glutamate racemase; Provisional; Region: PRK00865 1217737011026 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737011027 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1217737011028 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1217737011029 potential catalytic triad [active] 1217737011030 conserved cys residue [active] 1217737011031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737011032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737011033 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1217737011034 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1217737011035 potential catalytic triad [active] 1217737011036 conserved cys residue [active] 1217737011037 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737011038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737011039 DNA binding residues [nucleotide binding] 1217737011040 dimerization interface [polypeptide binding]; other site 1217737011041 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1217737011042 putative deaminase; Validated; Region: PRK06846 1217737011043 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1217737011044 active site 1217737011045 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1217737011046 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737011047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737011048 non-specific DNA binding site [nucleotide binding]; other site 1217737011049 salt bridge; other site 1217737011050 sequence-specific DNA binding site [nucleotide binding]; other site 1217737011051 Cupin domain; Region: Cupin_2; pfam07883 1217737011052 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1217737011053 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1217737011054 amphipathic channel; other site 1217737011055 Asn-Pro-Ala signature motifs; other site 1217737011056 Predicted transcriptional regulator [Transcription]; Region: COG1959 1217737011057 Transcriptional regulator; Region: Rrf2; pfam02082 1217737011058 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1217737011059 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1217737011060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737011061 Walker A/P-loop; other site 1217737011062 ATP binding site [chemical binding]; other site 1217737011063 Q-loop/lid; other site 1217737011064 ABC transporter signature motif; other site 1217737011065 Walker B; other site 1217737011066 D-loop; other site 1217737011067 H-loop/switch region; other site 1217737011068 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1217737011069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737011070 active site 1217737011071 motif I; other site 1217737011072 motif II; other site 1217737011073 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1217737011074 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1217737011075 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1217737011076 ligand binding site [chemical binding]; other site 1217737011077 flagellar motor protein MotA; Validated; Region: PRK08124 1217737011078 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1217737011079 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1217737011080 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1217737011081 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1217737011082 active site 1217737011083 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1217737011084 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1217737011085 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1217737011086 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1217737011087 L-aspartate oxidase; Provisional; Region: PRK06175 1217737011088 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1217737011089 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1217737011090 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1217737011091 putative Iron-sulfur protein interface [polypeptide binding]; other site 1217737011092 proximal heme binding site [chemical binding]; other site 1217737011093 distal heme binding site [chemical binding]; other site 1217737011094 putative dimer interface [polypeptide binding]; other site 1217737011095 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1217737011096 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1217737011097 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1217737011098 GIY-YIG motif/motif A; other site 1217737011099 active site 1217737011100 catalytic site [active] 1217737011101 putative DNA binding site [nucleotide binding]; other site 1217737011102 metal binding site [ion binding]; metal-binding site 1217737011103 UvrB/uvrC motif; Region: UVR; pfam02151 1217737011104 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1217737011105 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737011106 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1217737011107 catalytic residues [active] 1217737011108 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1217737011109 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1217737011110 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1217737011111 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1217737011112 Ligand binding site [chemical binding]; other site 1217737011113 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1217737011114 enoyl-CoA hydratase; Provisional; Region: PRK07658 1217737011115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1217737011116 substrate binding site [chemical binding]; other site 1217737011117 oxyanion hole (OAH) forming residues; other site 1217737011118 trimer interface [polypeptide binding]; other site 1217737011119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1217737011120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737011121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737011122 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1217737011123 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1217737011124 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1217737011125 acyl-activating enzyme (AAE) consensus motif; other site 1217737011126 putative AMP binding site [chemical binding]; other site 1217737011127 putative active site [active] 1217737011128 putative CoA binding site [chemical binding]; other site 1217737011129 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1217737011130 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1217737011131 siderophore binding site; other site 1217737011132 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1217737011133 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737011134 ABC-ATPase subunit interface; other site 1217737011135 dimer interface [polypeptide binding]; other site 1217737011136 putative PBP binding regions; other site 1217737011137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737011138 ABC-ATPase subunit interface; other site 1217737011139 dimer interface [polypeptide binding]; other site 1217737011140 putative PBP binding regions; other site 1217737011141 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1217737011142 DinB family; Region: DinB; pfam05163 1217737011143 DinB superfamily; Region: DinB_2; pfam12867 1217737011144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1217737011145 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1217737011146 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737011147 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1217737011148 Walker A/P-loop; other site 1217737011149 ATP binding site [chemical binding]; other site 1217737011150 Q-loop/lid; other site 1217737011151 ABC transporter signature motif; other site 1217737011152 Walker B; other site 1217737011153 D-loop; other site 1217737011154 H-loop/switch region; other site 1217737011155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737011156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737011157 dimer interface [polypeptide binding]; other site 1217737011158 phosphorylation site [posttranslational modification] 1217737011159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011160 ATP binding site [chemical binding]; other site 1217737011161 Mg2+ binding site [ion binding]; other site 1217737011162 G-X-G motif; other site 1217737011163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737011164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737011165 active site 1217737011166 phosphorylation site [posttranslational modification] 1217737011167 intermolecular recognition site; other site 1217737011168 dimerization interface [polypeptide binding]; other site 1217737011169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737011170 DNA binding site [nucleotide binding] 1217737011171 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1217737011172 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1217737011173 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1217737011174 putative RNA binding site [nucleotide binding]; other site 1217737011175 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 1217737011176 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1217737011177 active site 1217737011178 catalytic site [active] 1217737011179 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1217737011180 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1217737011181 Walker A/P-loop; other site 1217737011182 ATP binding site [chemical binding]; other site 1217737011183 Q-loop/lid; other site 1217737011184 ABC transporter signature motif; other site 1217737011185 Walker B; other site 1217737011186 D-loop; other site 1217737011187 H-loop/switch region; other site 1217737011188 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1217737011189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737011190 ABC-ATPase subunit interface; other site 1217737011191 dimer interface [polypeptide binding]; other site 1217737011192 putative PBP binding regions; other site 1217737011193 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1217737011194 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1217737011195 intersubunit interface [polypeptide binding]; other site 1217737011196 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011197 heme-binding site [chemical binding]; other site 1217737011198 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011199 heme-binding site [chemical binding]; other site 1217737011200 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011201 heme-binding site [chemical binding]; other site 1217737011202 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011203 heme-binding site [chemical binding]; other site 1217737011204 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011205 heme-binding site [chemical binding]; other site 1217737011206 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011207 heme-binding site [chemical binding]; other site 1217737011208 heme uptake protein IsdC; Region: IsdC; TIGR03656 1217737011209 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1217737011210 heme-binding site [chemical binding]; other site 1217737011211 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1217737011212 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1217737011213 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1217737011214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737011215 RNA binding surface [nucleotide binding]; other site 1217737011216 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1217737011217 probable active site [active] 1217737011218 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1217737011219 MutS domain III; Region: MutS_III; pfam05192 1217737011220 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1217737011221 Walker A/P-loop; other site 1217737011222 ATP binding site [chemical binding]; other site 1217737011223 Q-loop/lid; other site 1217737011224 ABC transporter signature motif; other site 1217737011225 Walker B; other site 1217737011226 D-loop; other site 1217737011227 H-loop/switch region; other site 1217737011228 Smr domain; Region: Smr; pfam01713 1217737011229 hypothetical protein; Provisional; Region: PRK08609 1217737011230 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1217737011231 active site 1217737011232 primer binding site [nucleotide binding]; other site 1217737011233 NTP binding site [chemical binding]; other site 1217737011234 metal binding triad [ion binding]; metal-binding site 1217737011235 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1217737011236 active site 1217737011237 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1217737011238 Colicin V production protein; Region: Colicin_V; pfam02674 1217737011239 cell division protein ZapA; Provisional; Region: PRK14126 1217737011240 ribonuclease HIII; Provisional; Region: PRK00996 1217737011241 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1217737011242 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1217737011243 RNA/DNA hybrid binding site [nucleotide binding]; other site 1217737011244 active site 1217737011245 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1217737011246 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1217737011247 putative dimer interface [polypeptide binding]; other site 1217737011248 putative anticodon binding site; other site 1217737011249 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1217737011250 homodimer interface [polypeptide binding]; other site 1217737011251 motif 1; other site 1217737011252 motif 2; other site 1217737011253 active site 1217737011254 motif 3; other site 1217737011255 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1217737011256 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1217737011257 putative tRNA-binding site [nucleotide binding]; other site 1217737011258 B3/4 domain; Region: B3_4; pfam03483 1217737011259 tRNA synthetase B5 domain; Region: B5; smart00874 1217737011260 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1217737011261 dimer interface [polypeptide binding]; other site 1217737011262 motif 1; other site 1217737011263 motif 3; other site 1217737011264 motif 2; other site 1217737011265 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1217737011266 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1217737011267 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1217737011268 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1217737011269 dimer interface [polypeptide binding]; other site 1217737011270 motif 1; other site 1217737011271 active site 1217737011272 motif 2; other site 1217737011273 motif 3; other site 1217737011274 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1217737011275 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1217737011276 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1217737011277 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1217737011278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737011279 Zn2+ binding site [ion binding]; other site 1217737011280 Mg2+ binding site [ion binding]; other site 1217737011281 CAAX protease self-immunity; Region: Abi; pfam02517 1217737011282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737011283 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1217737011284 putative substrate translocation pore; other site 1217737011285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737011286 HlyD family secretion protein; Region: HlyD_3; pfam13437 1217737011287 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1217737011288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737011289 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1217737011290 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1217737011291 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1217737011292 oligomer interface [polypeptide binding]; other site 1217737011293 active site 1217737011294 metal binding site [ion binding]; metal-binding site 1217737011295 dUTPase; Region: dUTPase_2; pfam08761 1217737011296 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1217737011297 active site 1217737011298 homodimer interface [polypeptide binding]; other site 1217737011299 metal binding site [ion binding]; metal-binding site 1217737011300 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1217737011301 23S rRNA binding site [nucleotide binding]; other site 1217737011302 L21 binding site [polypeptide binding]; other site 1217737011303 L13 binding site [polypeptide binding]; other site 1217737011304 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1217737011305 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1217737011306 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1217737011307 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1217737011308 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1217737011309 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1217737011310 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1217737011311 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1217737011312 active site 1217737011313 dimer interface [polypeptide binding]; other site 1217737011314 motif 1; other site 1217737011315 motif 2; other site 1217737011316 motif 3; other site 1217737011317 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1217737011318 anticodon binding site; other site 1217737011319 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1217737011320 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1217737011321 primosomal protein DnaI; Reviewed; Region: PRK08939 1217737011322 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1217737011323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737011324 Walker A motif; other site 1217737011325 ATP binding site [chemical binding]; other site 1217737011326 Walker B motif; other site 1217737011327 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1217737011328 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1217737011329 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1217737011330 ATP cone domain; Region: ATP-cone; pfam03477 1217737011331 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1217737011332 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1217737011333 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1217737011334 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1217737011335 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1217737011336 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1217737011337 CoA-binding site [chemical binding]; other site 1217737011338 ATP-binding [chemical binding]; other site 1217737011339 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1217737011340 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1217737011341 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1217737011342 DNA binding site [nucleotide binding] 1217737011343 catalytic residue [active] 1217737011344 H2TH interface [polypeptide binding]; other site 1217737011345 putative catalytic residues [active] 1217737011346 turnover-facilitating residue; other site 1217737011347 intercalation triad [nucleotide binding]; other site 1217737011348 8OG recognition residue [nucleotide binding]; other site 1217737011349 putative reading head residues; other site 1217737011350 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1217737011351 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1217737011352 DNA polymerase I; Provisional; Region: PRK05755 1217737011353 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1217737011354 active site 1217737011355 metal binding site 1 [ion binding]; metal-binding site 1217737011356 putative 5' ssDNA interaction site; other site 1217737011357 metal binding site 3; metal-binding site 1217737011358 metal binding site 2 [ion binding]; metal-binding site 1217737011359 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1217737011360 putative DNA binding site [nucleotide binding]; other site 1217737011361 putative metal binding site [ion binding]; other site 1217737011362 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1217737011363 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1217737011364 active site 1217737011365 DNA binding site [nucleotide binding] 1217737011366 catalytic site [active] 1217737011367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737011368 dimerization interface [polypeptide binding]; other site 1217737011369 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1217737011370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737011371 putative active site [active] 1217737011372 heme pocket [chemical binding]; other site 1217737011373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737011374 dimer interface [polypeptide binding]; other site 1217737011375 phosphorylation site [posttranslational modification] 1217737011376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011377 ATP binding site [chemical binding]; other site 1217737011378 Mg2+ binding site [ion binding]; other site 1217737011379 G-X-G motif; other site 1217737011380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737011381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737011382 active site 1217737011383 phosphorylation site [posttranslational modification] 1217737011384 intermolecular recognition site; other site 1217737011385 dimerization interface [polypeptide binding]; other site 1217737011386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737011387 DNA binding site [nucleotide binding] 1217737011388 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1217737011389 active site 2 [active] 1217737011390 active site 1 [active] 1217737011391 malate dehydrogenase; Reviewed; Region: PRK06223 1217737011392 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1217737011393 NAD(P) binding site [chemical binding]; other site 1217737011394 dimer interface [polypeptide binding]; other site 1217737011395 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737011396 substrate binding site [chemical binding]; other site 1217737011397 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1217737011398 isocitrate dehydrogenase; Validated; Region: PRK07362 1217737011399 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1217737011400 dimer interface [polypeptide binding]; other site 1217737011401 Citrate synthase; Region: Citrate_synt; pfam00285 1217737011402 active site 1217737011403 citrylCoA binding site [chemical binding]; other site 1217737011404 oxalacetate/citrate binding site [chemical binding]; other site 1217737011405 coenzyme A binding site [chemical binding]; other site 1217737011406 catalytic triad [active] 1217737011407 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1217737011408 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1217737011409 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1217737011410 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1217737011411 pyruvate kinase; Provisional; Region: PRK06354 1217737011412 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1217737011413 domain interfaces; other site 1217737011414 active site 1217737011415 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1217737011416 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1217737011417 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1217737011418 active site 1217737011419 ADP/pyrophosphate binding site [chemical binding]; other site 1217737011420 dimerization interface [polypeptide binding]; other site 1217737011421 allosteric effector site; other site 1217737011422 fructose-1,6-bisphosphate binding site; other site 1217737011423 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1217737011424 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1217737011425 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1217737011426 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1217737011427 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1217737011428 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1217737011429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737011430 DNA-binding site [nucleotide binding]; DNA binding site 1217737011431 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1217737011432 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1217737011433 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1217737011434 putative NAD(P) binding site [chemical binding]; other site 1217737011435 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1217737011436 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1217737011437 active site 1217737011438 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1217737011439 generic binding surface II; other site 1217737011440 generic binding surface I; other site 1217737011441 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1217737011442 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1217737011443 DHH family; Region: DHH; pfam01368 1217737011444 DHHA1 domain; Region: DHHA1; pfam02272 1217737011445 YtpI-like protein; Region: YtpI; pfam14007 1217737011446 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 1217737011447 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1217737011448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737011449 DNA-binding site [nucleotide binding]; DNA binding site 1217737011450 DRTGG domain; Region: DRTGG; pfam07085 1217737011451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1217737011452 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1217737011453 active site 2 [active] 1217737011454 active site 1 [active] 1217737011455 metal-dependent hydrolase; Provisional; Region: PRK00685 1217737011456 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1217737011457 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1217737011458 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1217737011459 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1217737011460 active site 1217737011461 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1217737011462 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1217737011463 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1217737011464 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1217737011465 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1217737011466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737011467 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1217737011468 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1217737011469 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1217737011470 hexamer interface [polypeptide binding]; other site 1217737011471 ligand binding site [chemical binding]; other site 1217737011472 putative active site [active] 1217737011473 NAD(P) binding site [chemical binding]; other site 1217737011474 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1217737011475 classical (c) SDRs; Region: SDR_c; cd05233 1217737011476 NAD(P) binding site [chemical binding]; other site 1217737011477 active site 1217737011478 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1217737011479 Ligand Binding Site [chemical binding]; other site 1217737011480 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1217737011481 argininosuccinate lyase; Provisional; Region: PRK00855 1217737011482 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1217737011483 active sites [active] 1217737011484 tetramer interface [polypeptide binding]; other site 1217737011485 argininosuccinate synthase; Provisional; Region: PRK13820 1217737011486 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1217737011487 ANP binding site [chemical binding]; other site 1217737011488 Substrate Binding Site II [chemical binding]; other site 1217737011489 Substrate Binding Site I [chemical binding]; other site 1217737011490 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737011491 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737011492 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737011493 EcsC protein family; Region: EcsC; pfam12787 1217737011494 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1217737011495 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1217737011496 nudix motif; other site 1217737011497 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1217737011498 propionate/acetate kinase; Provisional; Region: PRK12379 1217737011499 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1217737011500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737011501 S-adenosylmethionine binding site [chemical binding]; other site 1217737011502 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1217737011503 dimer interface [polypeptide binding]; other site 1217737011504 catalytic triad [active] 1217737011505 peroxidatic and resolving cysteines [active] 1217737011506 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1217737011507 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1217737011508 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1217737011509 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1217737011510 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1217737011511 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1217737011512 active site 1217737011513 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737011514 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1217737011515 dimer interface [polypeptide binding]; other site 1217737011516 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1217737011517 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1217737011518 active site 1217737011519 acyl-activating enzyme (AAE) consensus motif; other site 1217737011520 putative CoA binding site [chemical binding]; other site 1217737011521 AMP binding site [chemical binding]; other site 1217737011522 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737011523 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1217737011524 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1217737011525 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1217737011526 Ligand Binding Site [chemical binding]; other site 1217737011527 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1217737011528 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1217737011529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737011530 catalytic residue [active] 1217737011531 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1217737011532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737011533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737011534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1217737011535 dimerization interface [polypeptide binding]; other site 1217737011536 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737011537 EamA-like transporter family; Region: EamA; pfam00892 1217737011538 EamA-like transporter family; Region: EamA; pfam00892 1217737011539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737011540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737011541 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1217737011542 GAF domain; Region: GAF_2; pfam13185 1217737011543 methionine gamma-lyase; Provisional; Region: PRK06767 1217737011544 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1217737011545 homodimer interface [polypeptide binding]; other site 1217737011546 substrate-cofactor binding pocket; other site 1217737011547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737011548 catalytic residue [active] 1217737011549 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1217737011550 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1217737011551 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737011552 RNA binding surface [nucleotide binding]; other site 1217737011553 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1217737011554 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1217737011555 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1217737011556 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1217737011557 active site 1217737011558 HIGH motif; other site 1217737011559 dimer interface [polypeptide binding]; other site 1217737011560 KMSKS motif; other site 1217737011561 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737011562 RNA binding surface [nucleotide binding]; other site 1217737011563 maltose O-acetyltransferase; Provisional; Region: PRK10092 1217737011564 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1217737011565 active site 1217737011566 substrate binding site [chemical binding]; other site 1217737011567 trimer interface [polypeptide binding]; other site 1217737011568 CoA binding site [chemical binding]; other site 1217737011569 acetyl-CoA synthetase; Provisional; Region: PRK04319 1217737011570 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1217737011571 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1217737011572 active site 1217737011573 acyl-activating enzyme (AAE) consensus motif; other site 1217737011574 putative CoA binding site [chemical binding]; other site 1217737011575 AMP binding site [chemical binding]; other site 1217737011576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737011577 Coenzyme A binding pocket [chemical binding]; other site 1217737011578 FOG: CBS domain [General function prediction only]; Region: COG0517 1217737011579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1217737011580 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1217737011581 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1217737011582 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1217737011583 active site 1217737011584 Zn binding site [ion binding]; other site 1217737011585 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1217737011586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737011587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737011588 active site 1217737011589 phosphorylation site [posttranslational modification] 1217737011590 intermolecular recognition site; other site 1217737011591 dimerization interface [polypeptide binding]; other site 1217737011592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737011593 DNA binding site [nucleotide binding] 1217737011594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737011595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737011596 dimerization interface [polypeptide binding]; other site 1217737011597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737011598 dimer interface [polypeptide binding]; other site 1217737011599 phosphorylation site [posttranslational modification] 1217737011600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011601 ATP binding site [chemical binding]; other site 1217737011602 Mg2+ binding site [ion binding]; other site 1217737011603 G-X-G motif; other site 1217737011604 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1217737011605 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1217737011606 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1217737011607 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1217737011608 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1217737011609 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1217737011610 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1217737011611 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1217737011612 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1217737011613 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 1217737011614 potential frameshift: common BLAST hit: gi|225866658|ref|YP_002752036.1| minD family ATPase domain protein 1217737011615 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 1217737011616 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 1217737011617 catabolite control protein A; Region: ccpA; TIGR01481 1217737011618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737011619 DNA binding site [nucleotide binding] 1217737011620 domain linker motif; other site 1217737011621 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1217737011622 dimerization interface [polypeptide binding]; other site 1217737011623 effector binding site; other site 1217737011624 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1217737011625 Chorismate mutase type II; Region: CM_2; cl00693 1217737011626 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1217737011627 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1217737011628 putative dimer interface [polypeptide binding]; other site 1217737011629 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1217737011630 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1217737011631 putative dimer interface [polypeptide binding]; other site 1217737011632 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1217737011633 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1217737011634 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1217737011635 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1217737011636 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1217737011637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1217737011638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737011639 Coenzyme A binding pocket [chemical binding]; other site 1217737011640 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737011641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737011642 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737011643 EamA-like transporter family; Region: EamA; pfam00892 1217737011644 EamA-like transporter family; Region: EamA; pfam00892 1217737011645 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1217737011646 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737011647 DNA binding residues [nucleotide binding] 1217737011648 putative dimer interface [polypeptide binding]; other site 1217737011649 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1217737011650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1217737011651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1217737011652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1217737011653 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 1217737011654 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 1217737011655 active site 1217737011656 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1217737011657 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737011658 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1217737011659 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737011660 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737011661 active site 1217737011662 metal binding site [ion binding]; metal-binding site 1217737011663 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1217737011664 putative tRNA-binding site [nucleotide binding]; other site 1217737011665 hypothetical protein; Provisional; Region: PRK13668 1217737011666 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737011667 catalytic residues [active] 1217737011668 NTPase; Reviewed; Region: PRK03114 1217737011669 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1217737011670 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1217737011671 oligomer interface [polypeptide binding]; other site 1217737011672 active site 1217737011673 metal binding site [ion binding]; metal-binding site 1217737011674 Predicted small secreted protein [Function unknown]; Region: COG5584 1217737011675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737011676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737011677 S-adenosylmethionine binding site [chemical binding]; other site 1217737011678 YtzH-like protein; Region: YtzH; pfam14165 1217737011679 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737011680 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1217737011681 active site 1217737011682 substrate binding site [chemical binding]; other site 1217737011683 ATP binding site [chemical binding]; other site 1217737011684 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1217737011685 pullulanase, type I; Region: pulA_typeI; TIGR02104 1217737011686 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1217737011687 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1217737011688 Ca binding site [ion binding]; other site 1217737011689 active site 1217737011690 catalytic site [active] 1217737011691 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1217737011692 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1217737011693 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1217737011694 dipeptidase PepV; Reviewed; Region: PRK07318 1217737011695 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1217737011696 active site 1217737011697 metal binding site [ion binding]; metal-binding site 1217737011698 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1217737011699 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1217737011700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737011701 RNA binding surface [nucleotide binding]; other site 1217737011702 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1217737011703 active site 1217737011704 uracil binding [chemical binding]; other site 1217737011705 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1217737011706 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1217737011707 HI0933-like protein; Region: HI0933_like; pfam03486 1217737011708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737011709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737011710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737011711 putative substrate translocation pore; other site 1217737011712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737011713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737011714 dimerization interface [polypeptide binding]; other site 1217737011715 putative DNA binding site [nucleotide binding]; other site 1217737011716 putative Zn2+ binding site [ion binding]; other site 1217737011717 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1217737011718 putative hydrophobic ligand binding site [chemical binding]; other site 1217737011719 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 1217737011720 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1217737011721 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1217737011722 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1217737011723 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1217737011724 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1217737011725 NAD binding site [chemical binding]; other site 1217737011726 homodimer interface [polypeptide binding]; other site 1217737011727 active site 1217737011728 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1217737011729 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1217737011730 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1217737011731 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1217737011732 MoaE interaction surface [polypeptide binding]; other site 1217737011733 MoeB interaction surface [polypeptide binding]; other site 1217737011734 thiocarboxylated glycine; other site 1217737011735 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1217737011736 MoaE homodimer interface [polypeptide binding]; other site 1217737011737 MoaD interaction [polypeptide binding]; other site 1217737011738 active site residues [active] 1217737011739 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1217737011740 Walker A motif; other site 1217737011741 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1217737011742 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1217737011743 dimer interface [polypeptide binding]; other site 1217737011744 putative functional site; other site 1217737011745 putative MPT binding site; other site 1217737011746 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1217737011747 trimer interface [polypeptide binding]; other site 1217737011748 dimer interface [polypeptide binding]; other site 1217737011749 putative active site [active] 1217737011750 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1217737011751 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1217737011752 ATP binding site [chemical binding]; other site 1217737011753 substrate interface [chemical binding]; other site 1217737011754 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1217737011755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737011756 FeS/SAM binding site; other site 1217737011757 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1217737011758 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1217737011759 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1217737011760 active site residue [active] 1217737011761 homoserine O-acetyltransferase; Provisional; Region: PRK06765 1217737011762 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1217737011763 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737011764 Spore germination protein; Region: Spore_permease; pfam03845 1217737011765 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737011766 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737011767 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1217737011768 putative nucleotide binding site [chemical binding]; other site 1217737011769 putative metal binding site [ion binding]; other site 1217737011770 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1217737011771 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1217737011772 HIGH motif; other site 1217737011773 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1217737011774 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1217737011775 active site 1217737011776 KMSKS motif; other site 1217737011777 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1217737011778 tRNA binding surface [nucleotide binding]; other site 1217737011779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737011780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737011781 putative substrate translocation pore; other site 1217737011782 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1217737011783 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1217737011784 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1217737011785 TrkA-C domain; Region: TrkA_C; pfam02080 1217737011786 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1217737011787 Int/Topo IB signature motif; other site 1217737011788 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737011789 FtsX-like permease family; Region: FtsX; pfam02687 1217737011790 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737011791 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737011792 Walker A/P-loop; other site 1217737011793 ATP binding site [chemical binding]; other site 1217737011794 Q-loop/lid; other site 1217737011795 ABC transporter signature motif; other site 1217737011796 Walker B; other site 1217737011797 D-loop; other site 1217737011798 H-loop/switch region; other site 1217737011799 Protein of unknown function (DUF418); Region: DUF418; cl12135 1217737011800 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1217737011801 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1217737011802 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1217737011803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737011804 FeS/SAM binding site; other site 1217737011805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737011806 S-adenosylmethionine binding site [chemical binding]; other site 1217737011807 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1217737011808 aspartate racemase; Region: asp_race; TIGR00035 1217737011809 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1217737011810 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1217737011811 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1217737011812 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1217737011813 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737011814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737011815 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1217737011816 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1217737011817 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1217737011818 trimer interface [polypeptide binding]; other site 1217737011819 putative metal binding site [ion binding]; other site 1217737011820 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1217737011821 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1217737011822 active site 1217737011823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1217737011824 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1217737011825 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1217737011826 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1217737011827 GTP binding site; other site 1217737011828 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1217737011829 MPT binding site; other site 1217737011830 trimer interface [polypeptide binding]; other site 1217737011831 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1217737011832 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1217737011833 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1217737011834 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1217737011835 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1217737011836 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1217737011837 active site 1217737011838 substrate-binding site [chemical binding]; other site 1217737011839 metal-binding site [ion binding] 1217737011840 ATP binding site [chemical binding]; other site 1217737011841 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1217737011842 EamA-like transporter family; Region: EamA; pfam00892 1217737011843 EamA-like transporter family; Region: EamA; pfam00892 1217737011844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1217737011845 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1217737011846 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1217737011847 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1217737011848 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1217737011849 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1217737011850 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1217737011851 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1217737011852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737011853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011854 ATP binding site [chemical binding]; other site 1217737011855 Mg2+ binding site [ion binding]; other site 1217737011856 G-X-G motif; other site 1217737011857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737011858 dimer interface [polypeptide binding]; other site 1217737011859 phosphorylation site [posttranslational modification] 1217737011860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011861 ATP binding site [chemical binding]; other site 1217737011862 Mg2+ binding site [ion binding]; other site 1217737011863 G-X-G motif; other site 1217737011864 hydroperoxidase II; Provisional; Region: katE; PRK11249 1217737011865 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1217737011866 heme binding pocket [chemical binding]; other site 1217737011867 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1217737011868 domain interactions; other site 1217737011869 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1217737011870 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737011871 Sulfatase; Region: Sulfatase; pfam00884 1217737011872 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1217737011873 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1217737011874 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1217737011875 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1217737011876 NMT1-like family; Region: NMT1_2; pfam13379 1217737011877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1217737011878 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1217737011879 Walker A/P-loop; other site 1217737011880 ATP binding site [chemical binding]; other site 1217737011881 Q-loop/lid; other site 1217737011882 ABC transporter signature motif; other site 1217737011883 Walker B; other site 1217737011884 D-loop; other site 1217737011885 H-loop/switch region; other site 1217737011886 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1217737011887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737011888 dimer interface [polypeptide binding]; other site 1217737011889 conserved gate region; other site 1217737011890 putative PBP binding loops; other site 1217737011891 ABC-ATPase subunit interface; other site 1217737011892 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1217737011893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737011894 motif II; other site 1217737011895 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1217737011896 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1217737011897 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1217737011898 nudix motif; other site 1217737011899 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 1217737011900 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1217737011901 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737011902 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737011903 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1217737011904 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737011905 DNA binding residues [nucleotide binding] 1217737011906 dimer interface [polypeptide binding]; other site 1217737011907 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1217737011908 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1217737011909 Haemolytic domain; Region: Haemolytic; pfam01809 1217737011910 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1217737011911 active site clefts [active] 1217737011912 zinc binding site [ion binding]; other site 1217737011913 dimer interface [polypeptide binding]; other site 1217737011914 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1217737011915 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1217737011916 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1217737011917 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1217737011918 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1217737011919 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1217737011920 putative active site [active] 1217737011921 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1217737011922 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737011923 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737011924 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737011925 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737011926 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1217737011927 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1217737011928 Predicted membrane protein [Function unknown]; Region: COG3766 1217737011929 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1217737011930 hypothetical protein; Provisional; Region: PRK12473 1217737011931 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1217737011932 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1217737011933 G1 box; other site 1217737011934 GTP/Mg2+ binding site [chemical binding]; other site 1217737011935 Switch I region; other site 1217737011936 G2 box; other site 1217737011937 G3 box; other site 1217737011938 Switch II region; other site 1217737011939 G4 box; other site 1217737011940 G5 box; other site 1217737011941 Nucleoside recognition; Region: Gate; pfam07670 1217737011942 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1217737011943 Nucleoside recognition; Region: Gate; pfam07670 1217737011944 FeoA domain; Region: FeoA; pfam04023 1217737011945 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1217737011946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737011947 dimerization interface [polypeptide binding]; other site 1217737011948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737011949 dimer interface [polypeptide binding]; other site 1217737011950 phosphorylation site [posttranslational modification] 1217737011951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011952 ATP binding site [chemical binding]; other site 1217737011953 Mg2+ binding site [ion binding]; other site 1217737011954 G-X-G motif; other site 1217737011955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737011956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737011957 active site 1217737011958 phosphorylation site [posttranslational modification] 1217737011959 intermolecular recognition site; other site 1217737011960 dimerization interface [polypeptide binding]; other site 1217737011961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737011962 DNA binding site [nucleotide binding] 1217737011963 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1217737011964 active site 1217737011965 catalytic site [active] 1217737011966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737011967 active site 1217737011968 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1217737011969 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1217737011970 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1217737011971 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1217737011972 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1217737011973 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1217737011974 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737011975 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1217737011976 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737011977 FtsX-like permease family; Region: FtsX; pfam02687 1217737011978 rod shape-determining protein MreC; Provisional; Region: PRK13922 1217737011979 rod shape-determining protein MreC; Region: MreC; pfam04085 1217737011980 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737011981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737011982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737011983 dimerization interface [polypeptide binding]; other site 1217737011984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737011985 dimer interface [polypeptide binding]; other site 1217737011986 phosphorylation site [posttranslational modification] 1217737011987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737011988 ATP binding site [chemical binding]; other site 1217737011989 Mg2+ binding site [ion binding]; other site 1217737011990 G-X-G motif; other site 1217737011991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737011992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737011993 active site 1217737011994 phosphorylation site [posttranslational modification] 1217737011995 intermolecular recognition site; other site 1217737011996 dimerization interface [polypeptide binding]; other site 1217737011997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737011998 DNA binding site [nucleotide binding] 1217737011999 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737012000 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737012001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737012002 S-adenosylmethionine binding site [chemical binding]; other site 1217737012003 FtsX-like permease family; Region: FtsX; pfam02687 1217737012004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737012005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737012006 Walker A/P-loop; other site 1217737012007 ATP binding site [chemical binding]; other site 1217737012008 Q-loop/lid; other site 1217737012009 ABC transporter signature motif; other site 1217737012010 Walker B; other site 1217737012011 D-loop; other site 1217737012012 H-loop/switch region; other site 1217737012013 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1217737012014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1217737012015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1217737012016 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1217737012017 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737012018 Walker A/P-loop; other site 1217737012019 ATP binding site [chemical binding]; other site 1217737012020 Q-loop/lid; other site 1217737012021 ABC transporter signature motif; other site 1217737012022 Walker B; other site 1217737012023 D-loop; other site 1217737012024 H-loop/switch region; other site 1217737012025 Predicted integral membrane protein [Function unknown]; Region: COG5658 1217737012026 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1217737012027 SdpI/YhfL protein family; Region: SdpI; pfam13630 1217737012028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737012029 dimerization interface [polypeptide binding]; other site 1217737012030 putative DNA binding site [nucleotide binding]; other site 1217737012031 putative Zn2+ binding site [ion binding]; other site 1217737012032 RNA polymerase sigma factor; Provisional; Region: PRK12543 1217737012033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737012034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737012035 active site 1217737012036 phosphorylation site [posttranslational modification] 1217737012037 intermolecular recognition site; other site 1217737012038 dimerization interface [polypeptide binding]; other site 1217737012039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737012040 DNA binding site [nucleotide binding] 1217737012041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737012042 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1217737012043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737012044 ATP binding site [chemical binding]; other site 1217737012045 Mg2+ binding site [ion binding]; other site 1217737012046 G-X-G motif; other site 1217737012047 FtsX-like permease family; Region: FtsX; pfam02687 1217737012048 FtsX-like permease family; Region: FtsX; pfam02687 1217737012049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737012050 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737012051 Walker A/P-loop; other site 1217737012052 ATP binding site [chemical binding]; other site 1217737012053 Q-loop/lid; other site 1217737012054 ABC transporter signature motif; other site 1217737012055 Walker B; other site 1217737012056 D-loop; other site 1217737012057 H-loop/switch region; other site 1217737012058 GntP family permease; Region: GntP_permease; pfam02447 1217737012059 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1217737012060 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1217737012061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737012062 DNA-binding site [nucleotide binding]; DNA binding site 1217737012063 UTRA domain; Region: UTRA; pfam07702 1217737012064 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1217737012065 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1217737012066 substrate binding site [chemical binding]; other site 1217737012067 ATP binding site [chemical binding]; other site 1217737012068 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1217737012069 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1217737012070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737012071 catalytic residue [active] 1217737012072 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1217737012073 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1217737012074 active site 1217737012075 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1217737012076 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1217737012077 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1217737012078 dimerization interface [polypeptide binding]; other site 1217737012079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737012080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737012081 dimer interface [polypeptide binding]; other site 1217737012082 phosphorylation site [posttranslational modification] 1217737012083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737012084 ATP binding site [chemical binding]; other site 1217737012085 Mg2+ binding site [ion binding]; other site 1217737012086 G-X-G motif; other site 1217737012087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737012088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737012089 active site 1217737012090 phosphorylation site [posttranslational modification] 1217737012091 intermolecular recognition site; other site 1217737012092 dimerization interface [polypeptide binding]; other site 1217737012093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737012094 DNA binding site [nucleotide binding] 1217737012095 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1217737012096 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1217737012097 active site 1217737012098 octamer interface [polypeptide binding]; other site 1217737012099 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1217737012100 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1217737012101 acyl-activating enzyme (AAE) consensus motif; other site 1217737012102 putative AMP binding site [chemical binding]; other site 1217737012103 putative active site [active] 1217737012104 putative CoA binding site [chemical binding]; other site 1217737012105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1217737012106 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1217737012107 substrate binding site [chemical binding]; other site 1217737012108 oxyanion hole (OAH) forming residues; other site 1217737012109 trimer interface [polypeptide binding]; other site 1217737012110 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1217737012111 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1217737012112 nucleophilic elbow; other site 1217737012113 catalytic triad; other site 1217737012114 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1217737012115 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1217737012116 dimer interface [polypeptide binding]; other site 1217737012117 tetramer interface [polypeptide binding]; other site 1217737012118 PYR/PP interface [polypeptide binding]; other site 1217737012119 TPP binding site [chemical binding]; other site 1217737012120 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1217737012121 TPP-binding site; other site 1217737012122 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1217737012123 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1217737012124 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1217737012125 UbiA prenyltransferase family; Region: UbiA; pfam01040 1217737012126 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1217737012127 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737012128 DNA-binding site [nucleotide binding]; DNA binding site 1217737012129 RNA-binding motif; other site 1217737012130 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1217737012131 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1217737012132 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737012133 DNA binding residues [nucleotide binding] 1217737012134 dimer interface [polypeptide binding]; other site 1217737012135 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1217737012136 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1217737012137 active site flap/lid [active] 1217737012138 nucleophilic elbow; other site 1217737012139 catalytic triad [active] 1217737012140 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1217737012141 homodimer interface [polypeptide binding]; other site 1217737012142 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1217737012143 active site pocket [active] 1217737012144 glycogen synthase; Provisional; Region: glgA; PRK00654 1217737012145 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1217737012146 ADP-binding pocket [chemical binding]; other site 1217737012147 homodimer interface [polypeptide binding]; other site 1217737012148 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1217737012149 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1217737012150 ligand binding site; other site 1217737012151 oligomer interface; other site 1217737012152 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1217737012153 dimer interface [polypeptide binding]; other site 1217737012154 N-terminal domain interface [polypeptide binding]; other site 1217737012155 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1217737012156 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1217737012157 ligand binding site; other site 1217737012158 oligomer interface; other site 1217737012159 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1217737012160 dimer interface [polypeptide binding]; other site 1217737012161 N-terminal domain interface [polypeptide binding]; other site 1217737012162 sulfate 1 binding site; other site 1217737012163 glycogen branching enzyme; Provisional; Region: PRK12313 1217737012164 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1217737012165 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1217737012166 active site 1217737012167 catalytic site [active] 1217737012168 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1217737012169 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1217737012170 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1217737012171 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1217737012172 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737012173 NAD binding site [chemical binding]; other site 1217737012174 dimer interface [polypeptide binding]; other site 1217737012175 substrate binding site [chemical binding]; other site 1217737012176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737012177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737012178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737012179 putative substrate translocation pore; other site 1217737012180 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737012181 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1217737012182 MgtC family; Region: MgtC; pfam02308 1217737012183 Ion channel; Region: Ion_trans_2; pfam07885 1217737012184 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1217737012185 TrkA-N domain; Region: TrkA_N; pfam02254 1217737012186 YugN-like family; Region: YugN; pfam08868 1217737012187 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1217737012188 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1217737012189 active site 1217737012190 dimer interface [polypeptide binding]; other site 1217737012191 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1217737012192 dimer interface [polypeptide binding]; other site 1217737012193 active site 1217737012194 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1217737012195 general stress protein 13; Validated; Region: PRK08059 1217737012196 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1217737012197 RNA binding site [nucleotide binding]; other site 1217737012198 hypothetical protein; Validated; Region: PRK07682 1217737012199 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737012200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737012201 homodimer interface [polypeptide binding]; other site 1217737012202 catalytic residue [active] 1217737012203 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1217737012204 AsnC family; Region: AsnC_trans_reg; pfam01037 1217737012205 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1217737012206 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1217737012207 dimerization interface [polypeptide binding]; other site 1217737012208 ligand binding site [chemical binding]; other site 1217737012209 NADP binding site [chemical binding]; other site 1217737012210 catalytic site [active] 1217737012211 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1217737012212 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737012213 nucleophilic elbow; other site 1217737012214 catalytic triad; other site 1217737012215 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1217737012216 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1217737012217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737012218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737012219 homodimer interface [polypeptide binding]; other site 1217737012220 catalytic residue [active] 1217737012221 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1217737012222 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1217737012223 E-class dimer interface [polypeptide binding]; other site 1217737012224 P-class dimer interface [polypeptide binding]; other site 1217737012225 active site 1217737012226 Cu2+ binding site [ion binding]; other site 1217737012227 Zn2+ binding site [ion binding]; other site 1217737012228 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1217737012229 Kinase associated protein B; Region: KapB; pfam08810 1217737012230 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1217737012231 active site 1217737012232 catalytic site [active] 1217737012233 substrate binding site [chemical binding]; other site 1217737012234 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1217737012235 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1217737012236 transmembrane helices; other site 1217737012237 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1217737012238 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1217737012239 active site 1217737012240 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1217737012241 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1217737012242 motif 1; other site 1217737012243 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1217737012244 active site 1217737012245 motif 2; other site 1217737012246 motif 3; other site 1217737012247 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1217737012248 anticodon binding site; other site 1217737012249 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1217737012250 CoenzymeA binding site [chemical binding]; other site 1217737012251 subunit interaction site [polypeptide binding]; other site 1217737012252 PHB binding site; other site 1217737012253 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1217737012254 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1217737012255 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1217737012256 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1217737012257 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1217737012258 active site 1217737012259 tetramer interface; other site 1217737012260 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1217737012261 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1217737012262 active site 1217737012263 substrate binding site [chemical binding]; other site 1217737012264 metal binding site [ion binding]; metal-binding site 1217737012265 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1217737012266 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1217737012267 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1217737012268 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1217737012269 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1217737012270 interface (dimer of trimers) [polypeptide binding]; other site 1217737012271 Substrate-binding/catalytic site; other site 1217737012272 Zn-binding sites [ion binding]; other site 1217737012273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1217737012274 Putative membrane protein; Region: YuiB; pfam14068 1217737012275 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1217737012276 nudix motif; other site 1217737012277 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1217737012278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737012279 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1217737012280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737012281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737012282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1217737012283 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737012284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737012285 putative substrate translocation pore; other site 1217737012286 Helix-turn-helix domain; Region: HTH_36; pfam13730 1217737012287 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1217737012288 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1217737012289 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737012290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1217737012291 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737012292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737012293 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1217737012294 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1217737012295 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1217737012296 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1217737012297 hypothetical protein; Provisional; Region: PRK13669 1217737012298 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1217737012299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737012300 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1217737012301 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737012302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737012303 Walker A/P-loop; other site 1217737012304 ATP binding site [chemical binding]; other site 1217737012305 Q-loop/lid; other site 1217737012306 ABC transporter signature motif; other site 1217737012307 Walker B; other site 1217737012308 D-loop; other site 1217737012309 H-loop/switch region; other site 1217737012310 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1217737012311 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1217737012312 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1217737012313 PhnA protein; Region: PhnA; pfam03831 1217737012314 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1217737012315 PQQ-like domain; Region: PQQ_2; pfam13360 1217737012316 PQQ-like domain; Region: PQQ_2; pfam13360 1217737012317 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1217737012318 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737012319 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1217737012320 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1217737012321 active site 1217737012322 NTP binding site [chemical binding]; other site 1217737012323 metal binding triad [ion binding]; metal-binding site 1217737012324 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1217737012325 NifU-like domain; Region: NifU; pfam01106 1217737012326 spore coat protein YutH; Region: spore_yutH; TIGR02905 1217737012327 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1217737012328 tetramer interfaces [polypeptide binding]; other site 1217737012329 binuclear metal-binding site [ion binding]; other site 1217737012330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737012331 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1217737012332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737012333 active site 1217737012334 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1217737012335 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1217737012336 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1217737012337 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1217737012338 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1217737012339 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1217737012340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737012341 active site 1217737012342 motif I; other site 1217737012343 motif II; other site 1217737012344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737012345 Predicted transcriptional regulator [Transcription]; Region: COG2345 1217737012346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737012347 putative Zn2+ binding site [ion binding]; other site 1217737012348 putative DNA binding site [nucleotide binding]; other site 1217737012349 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1217737012350 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1217737012351 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1217737012352 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1217737012353 putative active site [active] 1217737012354 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1217737012355 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1217737012356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737012357 RNA binding surface [nucleotide binding]; other site 1217737012358 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1217737012359 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1217737012360 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1217737012361 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1217737012362 DNA binding residues [nucleotide binding] 1217737012363 dimer interface [polypeptide binding]; other site 1217737012364 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1217737012365 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1217737012366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1217737012367 catalytic core [active] 1217737012368 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1217737012369 putative deacylase active site [active] 1217737012370 lipoyl synthase; Provisional; Region: PRK05481 1217737012371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737012372 FeS/SAM binding site; other site 1217737012373 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737012374 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737012375 sporulation protein YunB; Region: spo_yunB; TIGR02832 1217737012376 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1217737012377 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1217737012378 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1217737012379 active site 1217737012380 metal binding site [ion binding]; metal-binding site 1217737012381 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1217737012382 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1217737012383 FeS assembly protein SufB; Region: sufB; TIGR01980 1217737012384 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1217737012385 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1217737012386 trimerization site [polypeptide binding]; other site 1217737012387 active site 1217737012388 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1217737012389 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1217737012390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737012391 catalytic residue [active] 1217737012392 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1217737012393 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1217737012394 FeS assembly protein SufD; Region: sufD; TIGR01981 1217737012395 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1217737012396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1217737012397 Walker A/P-loop; other site 1217737012398 ATP binding site [chemical binding]; other site 1217737012399 Q-loop/lid; other site 1217737012400 ABC transporter signature motif; other site 1217737012401 Walker B; other site 1217737012402 D-loop; other site 1217737012403 H-loop/switch region; other site 1217737012404 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1217737012405 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1217737012406 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1217737012407 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1217737012408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737012409 ABC-ATPase subunit interface; other site 1217737012410 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1217737012411 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1217737012412 Walker A/P-loop; other site 1217737012413 ATP binding site [chemical binding]; other site 1217737012414 Q-loop/lid; other site 1217737012415 ABC transporter signature motif; other site 1217737012416 Walker B; other site 1217737012417 D-loop; other site 1217737012418 H-loop/switch region; other site 1217737012419 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1217737012420 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737012421 catalytic residues [active] 1217737012422 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1217737012423 putative active site [active] 1217737012424 putative metal binding site [ion binding]; other site 1217737012425 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1217737012426 lipoyl attachment site [posttranslational modification]; other site 1217737012427 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1217737012428 ArsC family; Region: ArsC; pfam03960 1217737012429 putative ArsC-like catalytic residues; other site 1217737012430 putative TRX-like catalytic residues [active] 1217737012431 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1217737012432 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1217737012433 active site 1217737012434 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1217737012435 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1217737012436 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1217737012437 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1217737012438 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737012439 NAD binding site [chemical binding]; other site 1217737012440 dimer interface [polypeptide binding]; other site 1217737012441 substrate binding site [chemical binding]; other site 1217737012442 Coat F domain; Region: Coat_F; pfam07875 1217737012443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1217737012444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1217737012445 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1217737012446 active site 1217737012447 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1217737012448 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1217737012449 dimer interface [polypeptide binding]; other site 1217737012450 active site 1217737012451 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1217737012452 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1217737012453 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1217737012454 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1217737012455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1217737012456 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1217737012457 substrate binding site [chemical binding]; other site 1217737012458 oxyanion hole (OAH) forming residues; other site 1217737012459 YuzL-like protein; Region: YuzL; pfam14115 1217737012460 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737012461 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1217737012462 Proline dehydrogenase; Region: Pro_dh; cl03282 1217737012463 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1217737012464 Domain of unknown function DUF77; Region: DUF77; pfam01910 1217737012465 Cache domain; Region: Cache_1; pfam02743 1217737012466 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737012467 dimerization interface [polypeptide binding]; other site 1217737012468 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737012469 dimer interface [polypeptide binding]; other site 1217737012470 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737012471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737012472 dimer interface [polypeptide binding]; other site 1217737012473 putative CheW interface [polypeptide binding]; other site 1217737012474 Predicted transcriptional regulators [Transcription]; Region: COG1378 1217737012475 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1217737012476 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1217737012477 C-terminal domain interface [polypeptide binding]; other site 1217737012478 sugar binding site [chemical binding]; other site 1217737012479 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1217737012480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737012481 putative substrate translocation pore; other site 1217737012482 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1217737012483 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1217737012484 MAEBL; Provisional; Region: PTZ00121 1217737012485 OxaA-like protein precursor; Validated; Region: PRK01622 1217737012486 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737012487 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737012488 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737012489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1217737012490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737012491 hypothetical protein; Provisional; Region: PRK06758 1217737012492 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1217737012493 active site 1217737012494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737012495 non-specific DNA binding site [nucleotide binding]; other site 1217737012496 salt bridge; other site 1217737012497 sequence-specific DNA binding site [nucleotide binding]; other site 1217737012498 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737012499 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737012500 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 1217737012501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1217737012502 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1217737012503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737012504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737012505 active site 1217737012506 phosphorylation site [posttranslational modification] 1217737012507 intermolecular recognition site; other site 1217737012508 dimerization interface [polypeptide binding]; other site 1217737012509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737012510 DNA binding site [nucleotide binding] 1217737012511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737012512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737012513 dimer interface [polypeptide binding]; other site 1217737012514 phosphorylation site [posttranslational modification] 1217737012515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737012516 ATP binding site [chemical binding]; other site 1217737012517 Mg2+ binding site [ion binding]; other site 1217737012518 G-X-G motif; other site 1217737012519 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737012520 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1217737012521 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1217737012522 active site 1217737012523 HIGH motif; other site 1217737012524 KMSKS motif; other site 1217737012525 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1217737012526 tRNA binding surface [nucleotide binding]; other site 1217737012527 anticodon binding site; other site 1217737012528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737012529 S-adenosylmethionine binding site [chemical binding]; other site 1217737012530 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1217737012531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737012532 dimerization interface [polypeptide binding]; other site 1217737012533 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737012534 dimer interface [polypeptide binding]; other site 1217737012535 putative CheW interface [polypeptide binding]; other site 1217737012536 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1217737012537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737012538 dimerization interface [polypeptide binding]; other site 1217737012539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737012540 dimer interface [polypeptide binding]; other site 1217737012541 putative CheW interface [polypeptide binding]; other site 1217737012542 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1217737012543 Homeodomain-like domain; Region: HTH_23; cl17451 1217737012544 putative transposase OrfB; Reviewed; Region: PHA02517 1217737012545 HTH-like domain; Region: HTH_21; pfam13276 1217737012546 Integrase core domain; Region: rve; pfam00665 1217737012547 Integrase core domain; Region: rve_2; pfam13333 1217737012548 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1217737012549 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1217737012550 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1217737012551 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1217737012552 active site 1217737012553 Zn binding site [ion binding]; other site 1217737012554 Pirin-related protein [General function prediction only]; Region: COG1741 1217737012555 Pirin; Region: Pirin; pfam02678 1217737012556 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737012557 MarR family; Region: MarR_2; pfam12802 1217737012558 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 1217737012559 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1217737012560 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1217737012561 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1217737012562 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1217737012563 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1217737012564 TrkA-C domain; Region: TrkA_C; pfam02080 1217737012565 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737012566 amino acid carrier protein; Region: agcS; TIGR00835 1217737012567 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1217737012568 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1217737012569 dimerization interface [polypeptide binding]; other site 1217737012570 DPS ferroxidase diiron center [ion binding]; other site 1217737012571 ion pore; other site 1217737012572 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1217737012573 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1217737012574 metal binding site [ion binding]; metal-binding site 1217737012575 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1217737012576 Ferritin-like domain; Region: Ferritin; pfam00210 1217737012577 ferroxidase diiron center [ion binding]; other site 1217737012578 Predicted membrane protein [Function unknown]; Region: COG2311 1217737012579 Protein of unknown function (DUF418); Region: DUF418; cl12135 1217737012580 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1217737012581 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737012582 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737012583 Nucleoside recognition; Region: Gate; pfam07670 1217737012584 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737012585 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737012586 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737012587 Nucleoside recognition; Region: Gate; pfam07670 1217737012588 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737012589 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737012590 amino acid carrier protein; Region: agcS; TIGR00835 1217737012591 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1217737012592 amino acid carrier protein; Region: agcS; TIGR00835 1217737012593 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1217737012594 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1217737012595 NAD binding site [chemical binding]; other site 1217737012596 substrate binding site [chemical binding]; other site 1217737012597 putative active site [active] 1217737012598 Peptidase M60-like family; Region: M60-like; pfam13402 1217737012599 Viral enhancin protein; Region: Enhancin; pfam03272 1217737012600 TQXA domain; Region: TQXA_dom; TIGR03934 1217737012601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737012602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737012603 active site 1217737012604 catalytic tetrad [active] 1217737012605 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1217737012606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737012607 putative substrate translocation pore; other site 1217737012608 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737012609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737012610 dimerization interface [polypeptide binding]; other site 1217737012611 putative DNA binding site [nucleotide binding]; other site 1217737012612 putative Zn2+ binding site [ion binding]; other site 1217737012613 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1217737012614 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1217737012615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737012616 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1217737012617 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1217737012618 active site 1217737012619 HIGH motif; other site 1217737012620 dimer interface [polypeptide binding]; other site 1217737012621 KMSKS motif; other site 1217737012622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737012623 RNA binding surface [nucleotide binding]; other site 1217737012624 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 1217737012625 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737012626 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1217737012627 SET domain; Region: SET; pfam00856 1217737012628 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 1217737012629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737012630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737012631 dimer interface [polypeptide binding]; other site 1217737012632 putative CheW interface [polypeptide binding]; other site 1217737012633 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1217737012634 putative phosphate binding site [ion binding]; other site 1217737012635 camphor resistance protein CrcB; Provisional; Region: PRK14219 1217737012636 camphor resistance protein CrcB; Provisional; Region: PRK14205 1217737012637 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 1217737012638 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1217737012639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737012640 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737012641 putative substrate translocation pore; other site 1217737012642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737012643 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737012644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737012645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737012646 ABC transporter; Region: ABC_tran_2; pfam12848 1217737012647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737012648 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1217737012649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737012650 Coenzyme A binding pocket [chemical binding]; other site 1217737012651 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 1217737012652 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1217737012653 Nuclease-related domain; Region: NERD; pfam08378 1217737012654 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1217737012655 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737012656 catalytic triad [active] 1217737012657 conserved cis-peptide bond; other site 1217737012658 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1217737012659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737012660 putative DNA binding site [nucleotide binding]; other site 1217737012661 putative Zn2+ binding site [ion binding]; other site 1217737012662 AsnC family; Region: AsnC_trans_reg; pfam01037 1217737012663 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1217737012664 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1217737012665 AsnC family; Region: AsnC_trans_reg; pfam01037 1217737012666 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1217737012667 active site clefts [active] 1217737012668 zinc binding site [ion binding]; other site 1217737012669 dimer interface [polypeptide binding]; other site 1217737012670 cyanate hydratase; Validated; Region: PRK02866 1217737012671 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1217737012672 oligomer interface [polypeptide binding]; other site 1217737012673 active site 1217737012674 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1217737012675 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1217737012676 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1217737012677 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1217737012678 Walker A/P-loop; other site 1217737012679 ATP binding site [chemical binding]; other site 1217737012680 Q-loop/lid; other site 1217737012681 ABC transporter signature motif; other site 1217737012682 Walker B; other site 1217737012683 D-loop; other site 1217737012684 H-loop/switch region; other site 1217737012685 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737012686 ABC-ATPase subunit interface; other site 1217737012687 dimer interface [polypeptide binding]; other site 1217737012688 putative PBP binding regions; other site 1217737012689 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1217737012690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737012691 ABC-ATPase subunit interface; other site 1217737012692 dimer interface [polypeptide binding]; other site 1217737012693 putative PBP binding regions; other site 1217737012694 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1217737012695 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1217737012696 intersubunit interface [polypeptide binding]; other site 1217737012697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737012698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737012699 active site 1217737012700 phosphorylation site [posttranslational modification] 1217737012701 intermolecular recognition site; other site 1217737012702 dimerization interface [polypeptide binding]; other site 1217737012703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737012704 DNA binding site [nucleotide binding] 1217737012705 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1217737012706 SmpB-tmRNA interface; other site 1217737012707 ribonuclease R; Region: RNase_R; TIGR02063 1217737012708 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1217737012709 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1217737012710 RNB domain; Region: RNB; pfam00773 1217737012711 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1217737012712 RNA binding site [nucleotide binding]; other site 1217737012713 Esterase/lipase [General function prediction only]; Region: COG1647 1217737012714 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1217737012715 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1217737012716 holin-like protein; Validated; Region: PRK01658 1217737012717 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1217737012718 active site 1217737012719 enolase; Provisional; Region: eno; PRK00077 1217737012720 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1217737012721 dimer interface [polypeptide binding]; other site 1217737012722 metal binding site [ion binding]; metal-binding site 1217737012723 substrate binding pocket [chemical binding]; other site 1217737012724 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1217737012725 phosphoglyceromutase; Provisional; Region: PRK05434 1217737012726 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1217737012727 triosephosphate isomerase; Provisional; Region: PRK14565 1217737012728 substrate binding site [chemical binding]; other site 1217737012729 dimer interface [polypeptide binding]; other site 1217737012730 catalytic triad [active] 1217737012731 Phosphoglycerate kinase; Region: PGK; pfam00162 1217737012732 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1217737012733 substrate binding site [chemical binding]; other site 1217737012734 hinge regions; other site 1217737012735 ADP binding site [chemical binding]; other site 1217737012736 catalytic site [active] 1217737012737 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1217737012738 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1217737012739 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1217737012740 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1217737012741 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1217737012742 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1217737012743 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1217737012744 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1217737012745 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1217737012746 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1217737012747 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1217737012748 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1217737012749 stage V sporulation protein AD; Provisional; Region: PRK12404 1217737012750 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1217737012751 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1217737012752 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1217737012753 Predicted membrane protein [Function unknown]; Region: COG2323 1217737012754 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1217737012755 Clp protease; Region: CLP_protease; pfam00574 1217737012756 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1217737012757 oligomer interface [polypeptide binding]; other site 1217737012758 active site residues [active] 1217737012759 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1217737012760 dimerization domain swap beta strand [polypeptide binding]; other site 1217737012761 regulatory protein interface [polypeptide binding]; other site 1217737012762 active site 1217737012763 regulatory phosphorylation site [posttranslational modification]; other site 1217737012764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1217737012765 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1217737012766 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1217737012767 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1217737012768 phosphate binding site [ion binding]; other site 1217737012769 putative substrate binding pocket [chemical binding]; other site 1217737012770 dimer interface [polypeptide binding]; other site 1217737012771 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1217737012772 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1217737012773 putative active site [active] 1217737012774 nucleotide binding site [chemical binding]; other site 1217737012775 nudix motif; other site 1217737012776 putative metal binding site [ion binding]; other site 1217737012777 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1217737012778 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1217737012779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737012780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737012781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737012782 binding surface 1217737012783 TPR motif; other site 1217737012784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737012785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1217737012786 binding surface 1217737012787 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1217737012788 TPR motif; other site 1217737012789 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1217737012790 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1217737012791 trimer interface [polypeptide binding]; other site 1217737012792 active site 1217737012793 substrate binding site [chemical binding]; other site 1217737012794 CoA binding site [chemical binding]; other site 1217737012795 pyrophosphatase PpaX; Provisional; Region: PRK13288 1217737012796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737012797 active site 1217737012798 motif I; other site 1217737012799 motif II; other site 1217737012800 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1217737012801 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1217737012802 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1217737012803 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1217737012804 Hpr binding site; other site 1217737012805 active site 1217737012806 homohexamer subunit interaction site [polypeptide binding]; other site 1217737012807 Predicted membrane protein [Function unknown]; Region: COG1950 1217737012808 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 1217737012809 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1217737012810 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1217737012811 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1217737012812 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1217737012813 excinuclease ABC subunit B; Provisional; Region: PRK05298 1217737012814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737012815 ATP binding site [chemical binding]; other site 1217737012816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737012817 nucleotide binding region [chemical binding]; other site 1217737012818 ATP-binding site [chemical binding]; other site 1217737012819 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1217737012820 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1217737012821 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 1217737012822 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1217737012823 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737012824 DNA binding residues [nucleotide binding] 1217737012825 dimer interface [polypeptide binding]; other site 1217737012826 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1217737012827 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737012828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737012829 non-specific DNA binding site [nucleotide binding]; other site 1217737012830 salt bridge; other site 1217737012831 sequence-specific DNA binding site [nucleotide binding]; other site 1217737012832 Predicted membrane protein [Function unknown]; Region: COG2855 1217737012833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737012834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737012835 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1217737012836 putative dimerization interface [polypeptide binding]; other site 1217737012837 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1217737012838 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737012839 DNA binding residues [nucleotide binding] 1217737012840 putative dimer interface [polypeptide binding]; other site 1217737012841 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1217737012842 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1217737012843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737012844 D-loop; other site 1217737012845 H-loop/switch region; other site 1217737012846 hypothetical protein; Provisional; Region: PRK12855 1217737012847 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737012848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737012849 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1217737012850 Walker A/P-loop; other site 1217737012851 ATP binding site [chemical binding]; other site 1217737012852 Q-loop/lid; other site 1217737012853 ABC transporter signature motif; other site 1217737012854 Walker B; other site 1217737012855 D-loop; other site 1217737012856 H-loop/switch region; other site 1217737012857 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1217737012858 protein binding site [polypeptide binding]; other site 1217737012859 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1217737012860 C-terminal peptidase (prc); Region: prc; TIGR00225 1217737012861 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1217737012862 protein binding site [polypeptide binding]; other site 1217737012863 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1217737012864 Catalytic dyad [active] 1217737012865 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1217737012866 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1217737012867 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1217737012868 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1217737012869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737012870 Walker A/P-loop; other site 1217737012871 ATP binding site [chemical binding]; other site 1217737012872 Q-loop/lid; other site 1217737012873 ABC transporter signature motif; other site 1217737012874 Walker B; other site 1217737012875 D-loop; other site 1217737012876 H-loop/switch region; other site 1217737012877 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1217737012878 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1217737012879 potential frameshift: common BLAST hit: gi|218900306|ref|YP_002448717.1| peptide chain release factor 2 1217737012880 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1217737012881 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1217737012882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1217737012883 nucleotide binding region [chemical binding]; other site 1217737012884 ATP-binding site [chemical binding]; other site 1217737012885 SEC-C motif; Region: SEC-C; pfam02810 1217737012886 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1217737012887 30S subunit binding site; other site 1217737012888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1217737012889 DNA-binding site [nucleotide binding]; DNA binding site 1217737012890 RNA-binding motif; other site 1217737012891 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1217737012892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737012893 active site 1217737012894 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1217737012895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737012896 ATP binding site [chemical binding]; other site 1217737012897 putative Mg++ binding site [ion binding]; other site 1217737012898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737012899 nucleotide binding region [chemical binding]; other site 1217737012900 ATP-binding site [chemical binding]; other site 1217737012901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1217737012902 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 1217737012903 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1217737012904 NlpC/P60 family; Region: NLPC_P60; pfam00877 1217737012905 Predicted transcriptional regulators [Transcription]; Region: COG1733 1217737012906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737012907 dimerization interface [polypeptide binding]; other site 1217737012908 putative DNA binding site [nucleotide binding]; other site 1217737012909 putative Zn2+ binding site [ion binding]; other site 1217737012910 EDD domain protein, DegV family; Region: DegV; TIGR00762 1217737012911 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1217737012912 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1217737012913 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1217737012914 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1217737012915 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1217737012916 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1217737012917 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1217737012918 active site 1217737012919 homodimer interface [polypeptide binding]; other site 1217737012920 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1217737012921 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1217737012922 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1217737012923 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1217737012924 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1217737012925 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1217737012926 Mg++ binding site [ion binding]; other site 1217737012927 putative catalytic motif [active] 1217737012928 substrate binding site [chemical binding]; other site 1217737012929 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737012930 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1217737012931 NodB motif; other site 1217737012932 active site 1217737012933 catalytic site [active] 1217737012934 Zn binding site [ion binding]; other site 1217737012935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737012936 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1217737012937 Walker A motif; other site 1217737012938 ATP binding site [chemical binding]; other site 1217737012939 Walker B motif; other site 1217737012940 arginine finger; other site 1217737012941 Transcriptional antiterminator [Transcription]; Region: COG3933 1217737012942 PRD domain; Region: PRD; pfam00874 1217737012943 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1217737012944 active pocket/dimerization site; other site 1217737012945 active site 1217737012946 phosphorylation site [posttranslational modification] 1217737012947 PRD domain; Region: PRD; pfam00874 1217737012948 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 1217737012949 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1217737012950 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1217737012951 Chromate transporter; Region: Chromate_transp; pfam02417 1217737012952 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1217737012953 putative active site [active] 1217737012954 YdjC motif; other site 1217737012955 Mg binding site [ion binding]; other site 1217737012956 putative homodimer interface [polypeptide binding]; other site 1217737012957 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1217737012958 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1217737012959 NAD binding site [chemical binding]; other site 1217737012960 sugar binding site [chemical binding]; other site 1217737012961 divalent metal binding site [ion binding]; other site 1217737012962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737012963 dimer interface [polypeptide binding]; other site 1217737012964 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1217737012965 active site 1217737012966 methionine cluster; other site 1217737012967 phosphorylation site [posttranslational modification] 1217737012968 metal binding site [ion binding]; metal-binding site 1217737012969 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1217737012970 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1217737012971 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1217737012972 active site 1217737012973 P-loop; other site 1217737012974 phosphorylation site [posttranslational modification] 1217737012975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737012976 S-adenosylmethionine binding site [chemical binding]; other site 1217737012977 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 1217737012978 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1217737012979 methionine cluster; other site 1217737012980 active site 1217737012981 phosphorylation site [posttranslational modification] 1217737012982 metal binding site [ion binding]; metal-binding site 1217737012983 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1217737012984 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1217737012985 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1217737012986 active site 1217737012987 P-loop; other site 1217737012988 phosphorylation site [posttranslational modification] 1217737012989 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1217737012990 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1217737012991 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1217737012992 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1217737012993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1217737012994 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1217737012995 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1217737012996 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1217737012997 Predicted membrane protein [Function unknown]; Region: COG1511 1217737012998 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1217737012999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737013000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737013001 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1217737013002 putative dimerization interface [polypeptide binding]; other site 1217737013003 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1217737013004 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1217737013005 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1217737013006 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1217737013007 transmembrane helices; other site 1217737013008 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1217737013009 ThiC-associated domain; Region: ThiC-associated; pfam13667 1217737013010 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1217737013011 L-lactate permease; Region: Lactate_perm; cl00701 1217737013012 glycolate transporter; Provisional; Region: PRK09695 1217737013013 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1217737013014 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1217737013015 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1217737013016 Sulfatase; Region: Sulfatase; pfam00884 1217737013017 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1217737013018 homodimer interface [polypeptide binding]; other site 1217737013019 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1217737013020 substrate-cofactor binding pocket; other site 1217737013021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737013022 catalytic residue [active] 1217737013023 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013024 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013025 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013026 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013027 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013028 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1217737013029 NlpC/P60 family; Region: NLPC_P60; pfam00877 1217737013030 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737013031 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737013032 Nucleoside recognition; Region: Gate; pfam07670 1217737013033 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737013034 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1217737013035 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1217737013036 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1217737013037 DXD motif; other site 1217737013038 BCCT family transporter; Region: BCCT; pfam02028 1217737013039 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013040 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737013041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1217737013042 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 1217737013043 Predicted membrane protein [Function unknown]; Region: COG4640 1217737013044 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1217737013045 Double zinc ribbon; Region: DZR; pfam12773 1217737013046 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1217737013047 Double zinc ribbon; Region: DZR; pfam12773 1217737013048 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1217737013049 SNF2 Helicase protein; Region: DUF3670; pfam12419 1217737013050 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1217737013051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737013052 ATP binding site [chemical binding]; other site 1217737013053 putative Mg++ binding site [ion binding]; other site 1217737013054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737013055 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1217737013056 nucleotide binding region [chemical binding]; other site 1217737013057 ATP-binding site [chemical binding]; other site 1217737013058 Predicted integral membrane protein [Function unknown]; Region: COG5652 1217737013059 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 1217737013060 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1217737013061 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1217737013062 ComK protein; Region: ComK; cl11560 1217737013063 RNA polymerase factor sigma-70; Validated; Region: PRK06759 1217737013064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737013065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737013066 DNA binding residues [nucleotide binding] 1217737013067 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1217737013068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1217737013069 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737013070 FtsX-like permease family; Region: FtsX; pfam02687 1217737013071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737013072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737013073 Walker A/P-loop; other site 1217737013074 ATP binding site [chemical binding]; other site 1217737013075 Q-loop/lid; other site 1217737013076 ABC transporter signature motif; other site 1217737013077 Walker B; other site 1217737013078 D-loop; other site 1217737013079 H-loop/switch region; other site 1217737013080 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1217737013081 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1217737013082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737013083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737013084 non-specific DNA binding site [nucleotide binding]; other site 1217737013085 salt bridge; other site 1217737013086 sequence-specific DNA binding site [nucleotide binding]; other site 1217737013087 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1217737013088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737013089 putative substrate translocation pore; other site 1217737013090 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1217737013091 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1217737013092 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 1217737013093 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1217737013094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737013095 dimerization interface [polypeptide binding]; other site 1217737013096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737013097 dimer interface [polypeptide binding]; other site 1217737013098 phosphorylation site [posttranslational modification] 1217737013099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737013100 ATP binding site [chemical binding]; other site 1217737013101 Mg2+ binding site [ion binding]; other site 1217737013102 G-X-G motif; other site 1217737013103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737013104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013105 active site 1217737013106 phosphorylation site [posttranslational modification] 1217737013107 intermolecular recognition site; other site 1217737013108 dimerization interface [polypeptide binding]; other site 1217737013109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737013110 DNA binding site [nucleotide binding] 1217737013111 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1217737013112 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1217737013113 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1217737013114 UDP-glucose 4-epimerase; Region: PLN02240 1217737013115 NAD binding site [chemical binding]; other site 1217737013116 homodimer interface [polypeptide binding]; other site 1217737013117 active site 1217737013118 substrate binding site [chemical binding]; other site 1217737013119 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1217737013120 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1217737013121 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1217737013122 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1217737013123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1217737013124 active site 1217737013125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1217737013126 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1217737013127 O-Antigen ligase; Region: Wzy_C; pfam04932 1217737013128 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1217737013129 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1217737013130 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1217737013131 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1217737013132 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1217737013133 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1217737013134 active site 1217737013135 tetramer interface; other site 1217737013136 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1217737013137 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1217737013138 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1217737013139 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1217737013140 Chain length determinant protein; Region: Wzz; cl15801 1217737013141 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1217737013142 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1217737013143 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1217737013144 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1217737013145 MreB and similar proteins; Region: MreB_like; cd10225 1217737013146 nucleotide binding site [chemical binding]; other site 1217737013147 Mg binding site [ion binding]; other site 1217737013148 putative protofilament interaction site [polypeptide binding]; other site 1217737013149 RodZ interaction site [polypeptide binding]; other site 1217737013150 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1217737013151 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737013152 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737013153 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1217737013154 Protein of unknown function (DUF502); Region: DUF502; cl01107 1217737013155 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737013156 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737013157 Walker A/P-loop; other site 1217737013158 ATP binding site [chemical binding]; other site 1217737013159 Q-loop/lid; other site 1217737013160 ABC transporter signature motif; other site 1217737013161 Walker B; other site 1217737013162 D-loop; other site 1217737013163 H-loop/switch region; other site 1217737013164 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737013165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737013166 Walker A/P-loop; other site 1217737013167 ATP binding site [chemical binding]; other site 1217737013168 Q-loop/lid; other site 1217737013169 ABC transporter signature motif; other site 1217737013170 Walker B; other site 1217737013171 D-loop; other site 1217737013172 H-loop/switch region; other site 1217737013173 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1217737013174 LytTr DNA-binding domain; Region: LytTR; pfam04397 1217737013175 Stage II sporulation protein; Region: SpoIID; pfam08486 1217737013176 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1217737013177 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1217737013178 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1217737013179 hinge; other site 1217737013180 active site 1217737013181 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1217737013182 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1217737013183 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1217737013184 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1217737013185 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1217737013186 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1217737013187 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1217737013188 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1217737013189 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1217737013190 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1217737013191 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1217737013192 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1217737013193 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1217737013194 4Fe-4S binding domain; Region: Fer4; cl02805 1217737013195 4Fe-4S binding domain; Region: Fer4; pfam00037 1217737013196 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1217737013197 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1217737013198 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 1217737013199 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1217737013200 NADH dehydrogenase subunit C; Validated; Region: PRK07735 1217737013201 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1217737013202 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1217737013203 NADH dehydrogenase subunit A; Validated; Region: PRK07756 1217737013204 PAS domain S-box; Region: sensory_box; TIGR00229 1217737013205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737013206 putative active site [active] 1217737013207 heme pocket [chemical binding]; other site 1217737013208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737013209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737013210 metal binding site [ion binding]; metal-binding site 1217737013211 active site 1217737013212 I-site; other site 1217737013213 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737013214 Protein of unknown function (DUF975); Region: DUF975; cl10504 1217737013215 Protein of unknown function (DUF975); Region: DUF975; cl10504 1217737013216 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1217737013217 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1217737013218 gamma subunit interface [polypeptide binding]; other site 1217737013219 epsilon subunit interface [polypeptide binding]; other site 1217737013220 LBP interface [polypeptide binding]; other site 1217737013221 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1217737013222 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1217737013223 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1217737013224 alpha subunit interaction interface [polypeptide binding]; other site 1217737013225 Walker A motif; other site 1217737013226 ATP binding site [chemical binding]; other site 1217737013227 Walker B motif; other site 1217737013228 inhibitor binding site; inhibition site 1217737013229 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1217737013230 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1217737013231 core domain interface [polypeptide binding]; other site 1217737013232 delta subunit interface [polypeptide binding]; other site 1217737013233 epsilon subunit interface [polypeptide binding]; other site 1217737013234 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1217737013235 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1217737013236 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1217737013237 beta subunit interaction interface [polypeptide binding]; other site 1217737013238 Walker A motif; other site 1217737013239 ATP binding site [chemical binding]; other site 1217737013240 Walker B motif; other site 1217737013241 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1217737013242 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1217737013243 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1217737013244 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1217737013245 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1217737013246 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1217737013247 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1217737013248 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1217737013249 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1217737013250 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1217737013251 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 1217737013252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737013253 active site 1217737013254 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1217737013255 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1217737013256 dimer interface [polypeptide binding]; other site 1217737013257 active site 1217737013258 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1217737013259 folate binding site [chemical binding]; other site 1217737013260 hypothetical protein; Provisional; Region: PRK13690 1217737013261 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1217737013262 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1217737013263 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1217737013264 active site 1217737013265 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1217737013266 HPr interaction site; other site 1217737013267 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1217737013268 active site 1217737013269 phosphorylation site [posttranslational modification] 1217737013270 Predicted membrane protein [Function unknown]; Region: COG2259 1217737013271 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1217737013272 putative transposase OrfB; Reviewed; Region: PHA02517 1217737013273 HTH-like domain; Region: HTH_21; pfam13276 1217737013274 Integrase core domain; Region: rve; pfam00665 1217737013275 Integrase core domain; Region: rve_2; pfam13333 1217737013276 Homeodomain-like domain; Region: HTH_23; cl17451 1217737013277 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 1217737013278 Predicted membrane protein [Function unknown]; Region: COG1971 1217737013279 Domain of unknown function DUF; Region: DUF204; pfam02659 1217737013280 Domain of unknown function DUF; Region: DUF204; pfam02659 1217737013281 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1217737013282 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1217737013283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1217737013284 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1217737013285 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1217737013286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737013287 S-adenosylmethionine binding site [chemical binding]; other site 1217737013288 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1217737013289 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1217737013290 RF-1 domain; Region: RF-1; pfam00472 1217737013291 thymidine kinase; Provisional; Region: PRK04296 1217737013292 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1217737013293 putative metal binding site [ion binding]; other site 1217737013294 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1217737013295 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1217737013296 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1217737013297 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1217737013298 RNA binding site [nucleotide binding]; other site 1217737013299 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1217737013300 multimer interface [polypeptide binding]; other site 1217737013301 Walker A motif; other site 1217737013302 ATP binding site [chemical binding]; other site 1217737013303 Walker B motif; other site 1217737013304 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1217737013305 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1217737013306 putative active site [active] 1217737013307 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1217737013308 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1217737013309 hinge; other site 1217737013310 active site 1217737013311 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1217737013312 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1217737013313 intersubunit interface [polypeptide binding]; other site 1217737013314 active site 1217737013315 zinc binding site [ion binding]; other site 1217737013316 Na+ binding site [ion binding]; other site 1217737013317 Response regulator receiver domain; Region: Response_reg; pfam00072 1217737013318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013319 active site 1217737013320 phosphorylation site [posttranslational modification] 1217737013321 intermolecular recognition site; other site 1217737013322 dimerization interface [polypeptide binding]; other site 1217737013323 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1217737013324 CTP synthetase; Validated; Region: pyrG; PRK05380 1217737013325 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1217737013326 Catalytic site [active] 1217737013327 active site 1217737013328 UTP binding site [chemical binding]; other site 1217737013329 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1217737013330 active site 1217737013331 putative oxyanion hole; other site 1217737013332 catalytic triad [active] 1217737013333 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1217737013334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737013335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737013336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1217737013337 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1217737013338 FAD binding site [chemical binding]; other site 1217737013339 homotetramer interface [polypeptide binding]; other site 1217737013340 substrate binding pocket [chemical binding]; other site 1217737013341 catalytic base [active] 1217737013342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1217737013343 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1217737013344 FAD binding site [chemical binding]; other site 1217737013345 homotetramer interface [polypeptide binding]; other site 1217737013346 substrate binding pocket [chemical binding]; other site 1217737013347 catalytic base [active] 1217737013348 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1217737013349 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1217737013350 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1217737013351 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1217737013352 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1217737013353 dimer interface [polypeptide binding]; other site 1217737013354 active site 1217737013355 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1217737013356 4Fe-4S binding domain; Region: Fer4; cl02805 1217737013357 Cysteine-rich domain; Region: CCG; pfam02754 1217737013358 Cysteine-rich domain; Region: CCG; pfam02754 1217737013359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737013360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737013361 salt bridge; other site 1217737013362 non-specific DNA binding site [nucleotide binding]; other site 1217737013363 sequence-specific DNA binding site [nucleotide binding]; other site 1217737013364 Homeodomain-like domain; Region: HTH_23; pfam13384 1217737013365 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1217737013366 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737013367 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737013368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737013369 non-specific DNA binding site [nucleotide binding]; other site 1217737013370 salt bridge; other site 1217737013371 sequence-specific DNA binding site [nucleotide binding]; other site 1217737013372 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1217737013373 active site 1217737013374 catalytic residues [active] 1217737013375 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1217737013376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737013377 catalytic residues [active] 1217737013378 SIR2-like domain; Region: SIR2_2; pfam13289 1217737013379 AAA ATPase domain; Region: AAA_16; pfam13191 1217737013380 AAA domain; Region: AAA_22; pfam13401 1217737013381 Integrase core domain; Region: rve; pfam00665 1217737013382 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1217737013383 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1217737013384 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1217737013385 PLD-like domain; Region: PLDc_2; pfam13091 1217737013386 putative active site [active] 1217737013387 catalytic site [active] 1217737013388 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1217737013389 PLD-like domain; Region: PLDc_2; pfam13091 1217737013390 putative active site [active] 1217737013391 catalytic site [active] 1217737013392 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1217737013393 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 1217737013394 PAS domain S-box; Region: sensory_box; TIGR00229 1217737013395 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737013396 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737013397 metal binding site [ion binding]; metal-binding site 1217737013398 active site 1217737013399 I-site; other site 1217737013400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1217737013401 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 1217737013402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737013403 non-specific DNA binding site [nucleotide binding]; other site 1217737013404 salt bridge; other site 1217737013405 sequence-specific DNA binding site [nucleotide binding]; other site 1217737013406 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1217737013407 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1217737013408 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1217737013409 active site 1217737013410 Zn binding site [ion binding]; other site 1217737013411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737013412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013413 active site 1217737013414 phosphorylation site [posttranslational modification] 1217737013415 intermolecular recognition site; other site 1217737013416 dimerization interface [polypeptide binding]; other site 1217737013417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737013418 DNA binding residues [nucleotide binding] 1217737013419 dimerization interface [polypeptide binding]; other site 1217737013420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1217737013421 Histidine kinase; Region: HisKA_3; pfam07730 1217737013422 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1217737013423 ATP binding site [chemical binding]; other site 1217737013424 Mg2+ binding site [ion binding]; other site 1217737013425 G-X-G motif; other site 1217737013426 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1217737013427 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1217737013428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737013429 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1217737013430 Walker A/P-loop; other site 1217737013431 ATP binding site [chemical binding]; other site 1217737013432 Q-loop/lid; other site 1217737013433 ABC transporter signature motif; other site 1217737013434 Walker B; other site 1217737013435 D-loop; other site 1217737013436 H-loop/switch region; other site 1217737013437 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1217737013438 active site 1217737013439 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1217737013440 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1217737013441 Collagen binding domain; Region: Collagen_bind; pfam05737 1217737013442 Collagen binding domain; Region: Collagen_bind; pfam05737 1217737013443 Collagen binding domain; Region: Collagen_bind; pfam05737 1217737013444 Collagen binding domain; Region: Collagen_bind; pfam05737 1217737013445 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013446 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013447 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013448 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013449 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013450 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013451 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1217737013452 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013453 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013454 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013455 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013456 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1217737013457 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013458 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013459 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013460 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013461 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013462 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1217737013463 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013464 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013465 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013466 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013467 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737013468 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1217737013469 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1217737013470 PA/protease or protease-like domain interface [polypeptide binding]; other site 1217737013471 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1217737013472 Peptidase family M28; Region: Peptidase_M28; pfam04389 1217737013473 metal binding site [ion binding]; metal-binding site 1217737013474 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1217737013475 RNA polymerase sigma factor; Provisional; Region: PRK12522 1217737013476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737013477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737013478 DNA binding residues [nucleotide binding] 1217737013479 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1217737013480 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1217737013481 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1217737013482 active site 1217737013483 HIGH motif; other site 1217737013484 KMSK motif region; other site 1217737013485 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1217737013486 tRNA binding surface [nucleotide binding]; other site 1217737013487 anticodon binding site; other site 1217737013488 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1217737013489 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1217737013490 putative dimer interface [polypeptide binding]; other site 1217737013491 catalytic triad [active] 1217737013492 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737013493 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1217737013494 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1217737013495 agmatinase; Region: agmatinase; TIGR01230 1217737013496 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1217737013497 putative active site [active] 1217737013498 Mn binding site [ion binding]; other site 1217737013499 spermidine synthase; Provisional; Region: PRK00811 1217737013500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737013501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737013502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737013503 putative substrate translocation pore; other site 1217737013504 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1217737013505 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1217737013506 DNA binding residues [nucleotide binding] 1217737013507 putative dimer interface [polypeptide binding]; other site 1217737013508 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1217737013509 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1217737013510 active site 1217737013511 catalytic site [active] 1217737013512 metal binding site [ion binding]; metal-binding site 1217737013513 dimer interface [polypeptide binding]; other site 1217737013514 Transglycosylase; Region: Transgly; pfam00912 1217737013515 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1217737013516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1217737013517 YwhD family; Region: YwhD; pfam08741 1217737013518 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1217737013519 Peptidase family M50; Region: Peptidase_M50; pfam02163 1217737013520 active site 1217737013521 putative substrate binding region [chemical binding]; other site 1217737013522 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1217737013523 active site 1 [active] 1217737013524 dimer interface [polypeptide binding]; other site 1217737013525 hexamer interface [polypeptide binding]; other site 1217737013526 active site 2 [active] 1217737013527 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1217737013528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737013529 Zn2+ binding site [ion binding]; other site 1217737013530 Mg2+ binding site [ion binding]; other site 1217737013531 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1217737013532 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1217737013533 intersubunit interface [polypeptide binding]; other site 1217737013534 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1217737013535 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1217737013536 Walker A/P-loop; other site 1217737013537 ATP binding site [chemical binding]; other site 1217737013538 Q-loop/lid; other site 1217737013539 ABC transporter signature motif; other site 1217737013540 Walker B; other site 1217737013541 D-loop; other site 1217737013542 H-loop/switch region; other site 1217737013543 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1217737013544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737013545 ABC-ATPase subunit interface; other site 1217737013546 dimer interface [polypeptide binding]; other site 1217737013547 putative PBP binding regions; other site 1217737013548 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1217737013549 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737013550 ABC-ATPase subunit interface; other site 1217737013551 dimer interface [polypeptide binding]; other site 1217737013552 putative PBP binding regions; other site 1217737013553 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1217737013554 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1217737013555 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1217737013556 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1217737013557 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1217737013558 putative heme peroxidase; Provisional; Region: PRK12276 1217737013559 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1217737013560 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737013561 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1217737013562 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1217737013563 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1217737013564 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1217737013565 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1217737013566 Ion channel; Region: Ion_trans_2; pfam07885 1217737013567 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1217737013568 TrkA-N domain; Region: TrkA_N; pfam02254 1217737013569 TrkA-C domain; Region: TrkA_C; pfam02080 1217737013570 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1217737013571 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737013572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737013573 motif II; other site 1217737013574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737013575 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1217737013576 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1217737013577 ligand binding site [chemical binding]; other site 1217737013578 active site 1217737013579 UGI interface [polypeptide binding]; other site 1217737013580 catalytic site [active] 1217737013581 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1217737013582 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1217737013583 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1217737013584 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737013585 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1217737013586 Walker A/P-loop; other site 1217737013587 ATP binding site [chemical binding]; other site 1217737013588 Q-loop/lid; other site 1217737013589 ABC transporter signature motif; other site 1217737013590 Walker B; other site 1217737013591 D-loop; other site 1217737013592 H-loop/switch region; other site 1217737013593 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1217737013594 active site 1217737013595 catalytic triad [active] 1217737013596 oxyanion hole [active] 1217737013597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737013598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737013599 DNA binding site [nucleotide binding] 1217737013600 domain linker motif; other site 1217737013601 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1217737013602 putative dimerization interface [polypeptide binding]; other site 1217737013603 putative ligand binding site [chemical binding]; other site 1217737013604 Predicted membrane protein [Function unknown]; Region: COG2364 1217737013605 homoserine dehydrogenase; Provisional; Region: PRK06349 1217737013606 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1217737013607 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1217737013608 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1217737013609 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1217737013610 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1217737013611 proposed active site lysine [active] 1217737013612 conserved cys residue [active] 1217737013613 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 1217737013614 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1217737013615 homodimer interface [polypeptide binding]; other site 1217737013616 substrate-cofactor binding pocket; other site 1217737013617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737013618 catalytic residue [active] 1217737013619 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1217737013620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737013621 active site 1217737013622 motif I; other site 1217737013623 motif II; other site 1217737013624 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1217737013625 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1217737013626 ligand binding site [chemical binding]; other site 1217737013627 flexible hinge region; other site 1217737013628 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1217737013629 azoreductase; Provisional; Region: PRK13556 1217737013630 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1217737013631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013632 active site 1217737013633 phosphorylation site [posttranslational modification] 1217737013634 intermolecular recognition site; other site 1217737013635 dimerization interface [polypeptide binding]; other site 1217737013636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1217737013637 DNA binding residues [nucleotide binding] 1217737013638 dimerization interface [polypeptide binding]; other site 1217737013639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1217737013640 GAF domain; Region: GAF; pfam01590 1217737013641 GAF domain; Region: GAF_2; pfam13185 1217737013642 GAF domain; Region: GAF_3; pfam13492 1217737013643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1217737013644 Histidine kinase; Region: HisKA_3; pfam07730 1217737013645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737013646 ATP binding site [chemical binding]; other site 1217737013647 Mg2+ binding site [ion binding]; other site 1217737013648 G-X-G motif; other site 1217737013649 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1217737013650 dimer interface [polypeptide binding]; other site 1217737013651 substrate binding site [chemical binding]; other site 1217737013652 ATP binding site [chemical binding]; other site 1217737013653 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1217737013654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1217737013655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1217737013656 metal binding site [ion binding]; metal-binding site 1217737013657 active site 1217737013658 I-site; other site 1217737013659 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1217737013660 carbon starvation protein A; Provisional; Region: PRK15015 1217737013661 Carbon starvation protein CstA; Region: CstA; pfam02554 1217737013662 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1217737013663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013664 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1217737013665 active site 1217737013666 phosphorylation site [posttranslational modification] 1217737013667 intermolecular recognition site; other site 1217737013668 dimerization interface [polypeptide binding]; other site 1217737013669 LytTr DNA-binding domain; Region: LytTR; pfam04397 1217737013670 benzoate transport; Region: 2A0115; TIGR00895 1217737013671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737013672 putative substrate translocation pore; other site 1217737013673 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1217737013674 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1217737013675 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1217737013676 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1217737013677 Predicted membrane protein [Function unknown]; Region: COG2860 1217737013678 UPF0126 domain; Region: UPF0126; pfam03458 1217737013679 UPF0126 domain; Region: UPF0126; pfam03458 1217737013680 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1217737013681 heme-binding site [chemical binding]; other site 1217737013682 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737013683 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737013684 dimer interface [polypeptide binding]; other site 1217737013685 putative CheW interface [polypeptide binding]; other site 1217737013686 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1217737013687 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1217737013688 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737013689 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1217737013690 Ligand binding site; other site 1217737013691 Putative Catalytic site; other site 1217737013692 DXD motif; other site 1217737013693 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1217737013694 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1217737013695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1217737013696 active site 1217737013697 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1217737013698 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1217737013699 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1217737013700 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1217737013701 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1217737013702 Ligand binding site; other site 1217737013703 Putative Catalytic site; other site 1217737013704 DXD motif; other site 1217737013705 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737013706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737013707 NAD(P) binding site [chemical binding]; other site 1217737013708 active site 1217737013709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737013710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737013711 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737013712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737013713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737013714 ABC transporter; Region: ABC_tran_2; pfam12848 1217737013715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737013716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737013717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737013718 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1217737013719 Protein export membrane protein; Region: SecD_SecF; cl14618 1217737013720 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1217737013721 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1217737013722 SelR domain; Region: SelR; pfam01641 1217737013723 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1217737013724 antiholin-like protein LrgB; Provisional; Region: PRK04288 1217737013725 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1217737013726 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1217737013727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013728 active site 1217737013729 phosphorylation site [posttranslational modification] 1217737013730 intermolecular recognition site; other site 1217737013731 dimerization interface [polypeptide binding]; other site 1217737013732 LytTr DNA-binding domain; Region: LytTR; pfam04397 1217737013733 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1217737013734 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1217737013735 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1217737013736 Histidine kinase; Region: His_kinase; pfam06580 1217737013737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737013738 ATP binding site [chemical binding]; other site 1217737013739 Mg2+ binding site [ion binding]; other site 1217737013740 G-X-G motif; other site 1217737013741 benzoate transport; Region: 2A0115; TIGR00895 1217737013742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737013743 putative substrate translocation pore; other site 1217737013744 BCCT family transporter; Region: BCCT; pfam02028 1217737013745 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1217737013746 active site 1217737013747 dimer interface [polypeptide binding]; other site 1217737013748 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1217737013749 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1217737013750 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1217737013751 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1217737013752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1217737013753 NAD(P) binding site [chemical binding]; other site 1217737013754 active site 1217737013755 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1217737013756 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1217737013757 UDP-glucose 4-epimerase; Region: PLN02240 1217737013758 NAD binding site [chemical binding]; other site 1217737013759 homodimer interface [polypeptide binding]; other site 1217737013760 active site 1217737013761 substrate binding site [chemical binding]; other site 1217737013762 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1217737013763 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1217737013764 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1217737013765 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1217737013766 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1217737013767 ATP binding site [chemical binding]; other site 1217737013768 Mg++ binding site [ion binding]; other site 1217737013769 motif III; other site 1217737013770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737013771 nucleotide binding region [chemical binding]; other site 1217737013772 ATP-binding site [chemical binding]; other site 1217737013773 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1217737013774 RNA binding site [nucleotide binding]; other site 1217737013775 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1217737013776 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1217737013777 active site 1217737013778 oligoendopeptidase F; Region: pepF; TIGR00181 1217737013779 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1217737013780 active site 1217737013781 Zn binding site [ion binding]; other site 1217737013782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737013783 FeS/SAM binding site; other site 1217737013784 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1217737013785 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1217737013786 putative transposase OrfB; Reviewed; Region: PHA02517 1217737013787 HTH-like domain; Region: HTH_21; pfam13276 1217737013788 Integrase core domain; Region: rve; pfam00665 1217737013789 Integrase core domain; Region: rve_2; pfam13333 1217737013790 Homeodomain-like domain; Region: HTH_23; cl17451 1217737013791 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737013792 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737013793 catalytic residues [active] 1217737013794 catalytic nucleophile [active] 1217737013795 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737013796 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737013797 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737013798 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737013799 DNA binding site [nucleotide binding] 1217737013800 Recombinase; Region: Recombinase; pfam07508 1217737013801 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1217737013802 COG1961 Site-specific recombinases, DNA invertase Pin homologs 1217737013803 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1217737013804 non-specific DNA binding site [nucleotide binding]; other site 1217737013805 salt bridge; other site 1217737013806 sequence-specific DNA binding site [nucleotide binding]; other site 1217737013807 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 1217737013808 DNA methylase; Region: N6_N4_Mtase; cl17433 1217737013809 DNA methylase; Region: N6_N4_Mtase; cl17433 1217737013810 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737013811 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1217737013812 catalytic residues [active] 1217737013813 catalytic nucleophile [active] 1217737013814 Recombinase; Region: Recombinase; pfam07508 1217737013815 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1217737013816 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1217737013817 GIY-YIG motif/motif A; other site 1217737013818 active site 1217737013819 catalytic site [active] 1217737013820 metal binding site [ion binding]; metal-binding site 1217737013821 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737013822 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1217737013823 catalytic residues [active] 1217737013824 catalytic nucleophile [active] 1217737013825 Recombinase; Region: Recombinase; pfam07508 1217737013826 Replication initiation factor; Region: Rep_trans; pfam02486 1217737013827 Caspase domain; Region: Peptidase_C14; pfam00656 1217737013828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1217737013829 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1217737013830 FeS/SAM binding site; other site 1217737013831 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1217737013832 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1217737013833 TMP-binding site; other site 1217737013834 ATP-binding site [chemical binding]; other site 1217737013835 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1217737013836 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1217737013837 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1217737013838 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1217737013839 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1217737013840 protein binding site [polypeptide binding]; other site 1217737013841 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1217737013842 YycH protein; Region: YycI; pfam09648 1217737013843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1217737013844 YycH protein; Region: YycH; pfam07435 1217737013845 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1217737013846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1217737013847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737013848 dimerization interface [polypeptide binding]; other site 1217737013849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737013850 putative active site [active] 1217737013851 heme pocket [chemical binding]; other site 1217737013852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737013853 dimer interface [polypeptide binding]; other site 1217737013854 phosphorylation site [posttranslational modification] 1217737013855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737013856 ATP binding site [chemical binding]; other site 1217737013857 Mg2+ binding site [ion binding]; other site 1217737013858 G-X-G motif; other site 1217737013859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737013860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737013861 active site 1217737013862 phosphorylation site [posttranslational modification] 1217737013863 intermolecular recognition site; other site 1217737013864 dimerization interface [polypeptide binding]; other site 1217737013865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737013866 DNA binding site [nucleotide binding] 1217737013867 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1217737013868 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1217737013869 GDP-binding site [chemical binding]; other site 1217737013870 ACT binding site; other site 1217737013871 IMP binding site; other site 1217737013872 replicative DNA helicase; Provisional; Region: PRK05748 1217737013873 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1217737013874 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1217737013875 Walker A motif; other site 1217737013876 ATP binding site [chemical binding]; other site 1217737013877 Walker B motif; other site 1217737013878 DNA binding loops [nucleotide binding] 1217737013879 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1217737013880 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1217737013881 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1217737013882 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1217737013883 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1217737013884 DHH family; Region: DHH; pfam01368 1217737013885 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1217737013886 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1217737013887 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1217737013888 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1217737013889 dimer interface [polypeptide binding]; other site 1217737013890 ssDNA binding site [nucleotide binding]; other site 1217737013891 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737013892 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1217737013893 GTP-binding protein YchF; Reviewed; Region: PRK09601 1217737013894 YchF GTPase; Region: YchF; cd01900 1217737013895 G1 box; other site 1217737013896 GTP/Mg2+ binding site [chemical binding]; other site 1217737013897 Switch I region; other site 1217737013898 G2 box; other site 1217737013899 Switch II region; other site 1217737013900 G3 box; other site 1217737013901 G4 box; other site 1217737013902 G5 box; other site 1217737013903 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1217737013904 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1217737013905 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1217737013906 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1217737013907 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1217737013908 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1217737013909 ParB-like nuclease domain; Region: ParB; smart00470 1217737013910 KorB domain; Region: KorB; pfam08535 1217737013911 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1217737013912 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1217737013913 P-loop; other site 1217737013914 Magnesium ion binding site [ion binding]; other site 1217737013915 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1217737013916 Magnesium ion binding site [ion binding]; other site 1217737013917 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1217737013918 ParB-like nuclease domain; Region: ParBc; pfam02195 1217737013919 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1217737013920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737013921 S-adenosylmethionine binding site [chemical binding]; other site 1217737013922 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1217737013923 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1217737013924 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1217737013925 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1217737013926 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1217737013927 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1217737013928 G1 box; other site 1217737013929 GTP/Mg2+ binding site [chemical binding]; other site 1217737013930 Switch I region; other site 1217737013931 G2 box; other site 1217737013932 Switch II region; other site 1217737013933 G3 box; other site 1217737013934 G4 box; other site 1217737013935 G5 box; other site 1217737013936 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1217737013937 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1217737013938 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1217737013939 G-X-X-G motif; other site 1217737013940 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1217737013941 RxxxH motif; other site 1217737013942 OxaA-like protein precursor; Validated; Region: PRK02944 1217737013943 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1217737013944 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1217737013945 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1217737013946 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1217737013947 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1217737013948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737013949 Walker A motif; other site 1217737013950 ATP binding site [chemical binding]; other site 1217737013951 Walker B motif; other site 1217737013952 arginine finger; other site 1217737013953 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1217737013954 DnaA box-binding interface [nucleotide binding]; other site 1217737013955 DNA polymerase III subunit beta; Validated; Region: PRK05643 1217737013956 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1217737013957 putative DNA binding surface [nucleotide binding]; other site 1217737013958 dimer interface [polypeptide binding]; other site 1217737013959 beta-clamp/clamp loader binding surface; other site 1217737013960 beta-clamp/translesion DNA polymerase binding surface; other site 1217737013961 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1217737013962 recombination protein F; Reviewed; Region: recF; PRK00064 1217737013963 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1217737013964 Walker A/P-loop; other site 1217737013965 ATP binding site [chemical binding]; other site 1217737013966 Q-loop/lid; other site 1217737013967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737013968 ABC transporter signature motif; other site 1217737013969 Walker B; other site 1217737013970 D-loop; other site 1217737013971 H-loop/switch region; other site 1217737013972 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1217737013973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737013974 Mg2+ binding site [ion binding]; other site 1217737013975 G-X-G motif; other site 1217737013976 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1217737013977 anchoring element; other site 1217737013978 dimer interface [polypeptide binding]; other site 1217737013979 ATP binding site [chemical binding]; other site 1217737013980 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1217737013981 active site 1217737013982 putative metal-binding site [ion binding]; other site 1217737013983 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1217737013984 DNA gyrase subunit A; Validated; Region: PRK05560 1217737013985 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1217737013986 CAP-like domain; other site 1217737013987 active site 1217737013988 primary dimer interface [polypeptide binding]; other site 1217737013989 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737013990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737013991 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737013992 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737013993 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737013994 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1217737013995 YaaC-like Protein; Region: YaaC; pfam14175 1217737013996 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1217737013997 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1217737013998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1217737013999 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1217737014000 active site 1217737014001 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1217737014002 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1217737014003 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1217737014004 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1217737014005 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1217737014006 active site 1217737014007 multimer interface [polypeptide binding]; other site 1217737014008 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1217737014009 predicted active site [active] 1217737014010 catalytic triad [active] 1217737014011 seryl-tRNA synthetase; Provisional; Region: PRK05431 1217737014012 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1217737014013 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1217737014014 dimer interface [polypeptide binding]; other site 1217737014015 active site 1217737014016 motif 1; other site 1217737014017 motif 2; other site 1217737014018 motif 3; other site 1217737014019 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 1217737014020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737014021 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1217737014022 DNA binding residues [nucleotide binding] 1217737014023 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1217737014024 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1217737014025 Substrate-binding site [chemical binding]; other site 1217737014026 Substrate specificity [chemical binding]; other site 1217737014027 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1217737014028 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1217737014029 Substrate-binding site [chemical binding]; other site 1217737014030 Substrate specificity [chemical binding]; other site 1217737014031 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737014032 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1217737014033 catalytic triad [active] 1217737014034 conserved cis-peptide bond; other site 1217737014035 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1217737014036 nucleoside/Zn binding site; other site 1217737014037 dimer interface [polypeptide binding]; other site 1217737014038 catalytic motif [active] 1217737014039 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1217737014040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737014041 Walker A motif; other site 1217737014042 ATP binding site [chemical binding]; other site 1217737014043 Walker B motif; other site 1217737014044 arginine finger; other site 1217737014045 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1217737014046 hypothetical protein; Validated; Region: PRK00153 1217737014047 recombination protein RecR; Reviewed; Region: recR; PRK00076 1217737014048 RecR protein; Region: RecR; pfam02132 1217737014049 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1217737014050 putative active site [active] 1217737014051 putative metal-binding site [ion binding]; other site 1217737014052 tetramer interface [polypeptide binding]; other site 1217737014053 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1217737014054 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1217737014055 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1217737014056 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1217737014057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1217737014058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1217737014059 catalytic residue [active] 1217737014060 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1217737014061 thymidylate kinase; Validated; Region: tmk; PRK00698 1217737014062 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1217737014063 TMP-binding site; other site 1217737014064 ATP-binding site [chemical binding]; other site 1217737014065 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1217737014066 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1217737014067 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1217737014068 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1217737014069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737014070 S-adenosylmethionine binding site [chemical binding]; other site 1217737014071 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1217737014072 GIY-YIG motif/motif A; other site 1217737014073 putative active site [active] 1217737014074 putative metal binding site [ion binding]; other site 1217737014075 Predicted methyltransferases [General function prediction only]; Region: COG0313 1217737014076 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1217737014077 putative SAM binding site [chemical binding]; other site 1217737014078 putative homodimer interface [polypeptide binding]; other site 1217737014079 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1217737014080 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1217737014081 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1217737014082 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1217737014083 active site 1217737014084 HIGH motif; other site 1217737014085 KMSKS motif; other site 1217737014086 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1217737014087 tRNA binding surface [nucleotide binding]; other site 1217737014088 anticodon binding site; other site 1217737014089 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1217737014090 dimer interface [polypeptide binding]; other site 1217737014091 putative tRNA-binding site [nucleotide binding]; other site 1217737014092 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1217737014093 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1217737014094 active site 1217737014095 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1217737014096 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1217737014097 putative active site [active] 1217737014098 putative metal binding site [ion binding]; other site 1217737014099 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1217737014100 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1217737014101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737014102 S-adenosylmethionine binding site [chemical binding]; other site 1217737014103 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1217737014104 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1217737014105 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1217737014106 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1217737014107 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1217737014108 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1217737014109 pur operon repressor; Provisional; Region: PRK09213 1217737014110 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1217737014111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737014112 active site 1217737014113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1217737014114 homotrimer interaction site [polypeptide binding]; other site 1217737014115 putative active site [active] 1217737014116 regulatory protein SpoVG; Reviewed; Region: PRK13259 1217737014117 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1217737014118 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1217737014119 Substrate binding site; other site 1217737014120 Mg++ binding site; other site 1217737014121 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1217737014122 active site 1217737014123 substrate binding site [chemical binding]; other site 1217737014124 CoA binding site [chemical binding]; other site 1217737014125 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1217737014126 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1217737014127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737014128 active site 1217737014129 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1217737014130 putative active site [active] 1217737014131 catalytic residue [active] 1217737014132 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1217737014133 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1217737014134 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1217737014135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737014136 ATP binding site [chemical binding]; other site 1217737014137 putative Mg++ binding site [ion binding]; other site 1217737014138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737014139 nucleotide binding region [chemical binding]; other site 1217737014140 ATP-binding site [chemical binding]; other site 1217737014141 TRCF domain; Region: TRCF; pfam03461 1217737014142 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1217737014143 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1217737014144 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1217737014145 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1217737014146 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1217737014147 putative SAM binding site [chemical binding]; other site 1217737014148 putative homodimer interface [polypeptide binding]; other site 1217737014149 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1217737014150 homodimer interface [polypeptide binding]; other site 1217737014151 metal binding site [ion binding]; metal-binding site 1217737014152 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1217737014153 homodimer interface [polypeptide binding]; other site 1217737014154 active site 1217737014155 putative chemical substrate binding site [chemical binding]; other site 1217737014156 metal binding site [ion binding]; metal-binding site 1217737014157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1217737014158 RNA binding surface [nucleotide binding]; other site 1217737014159 sporulation protein YabP; Region: spore_yabP; TIGR02892 1217737014160 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1217737014161 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1217737014162 Septum formation initiator; Region: DivIC; pfam04977 1217737014163 hypothetical protein; Provisional; Region: PRK08582 1217737014164 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1217737014165 RNA binding site [nucleotide binding]; other site 1217737014166 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1217737014167 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1217737014168 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1217737014169 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1217737014170 Ligand Binding Site [chemical binding]; other site 1217737014171 TilS substrate binding domain; Region: TilS; pfam09179 1217737014172 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1217737014173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737014174 active site 1217737014175 FtsH Extracellular; Region: FtsH_ext; pfam06480 1217737014176 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1217737014177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737014178 Walker A motif; other site 1217737014179 ATP binding site [chemical binding]; other site 1217737014180 Walker B motif; other site 1217737014181 arginine finger; other site 1217737014182 Peptidase family M41; Region: Peptidase_M41; pfam01434 1217737014183 pantothenate kinase; Reviewed; Region: PRK13318 1217737014184 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1217737014185 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1217737014186 dimerization interface [polypeptide binding]; other site 1217737014187 domain crossover interface; other site 1217737014188 redox-dependent activation switch; other site 1217737014189 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1217737014190 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1217737014191 dimer interface [polypeptide binding]; other site 1217737014192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737014193 catalytic residue [active] 1217737014194 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1217737014195 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1217737014196 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1217737014197 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1217737014198 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1217737014199 glutamine binding [chemical binding]; other site 1217737014200 catalytic triad [active] 1217737014201 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1217737014202 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 1217737014203 homodimer interface [polypeptide binding]; other site 1217737014204 substrate-cofactor binding pocket; other site 1217737014205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737014206 catalytic residue [active] 1217737014207 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1217737014208 dihydropteroate synthase; Region: DHPS; TIGR01496 1217737014209 substrate binding pocket [chemical binding]; other site 1217737014210 dimer interface [polypeptide binding]; other site 1217737014211 inhibitor binding site; inhibition site 1217737014212 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1217737014213 homooctamer interface [polypeptide binding]; other site 1217737014214 active site 1217737014215 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1217737014216 catalytic center binding site [active] 1217737014217 ATP binding site [chemical binding]; other site 1217737014218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737014219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737014220 non-specific DNA binding site [nucleotide binding]; other site 1217737014221 salt bridge; other site 1217737014222 sequence-specific DNA binding site [nucleotide binding]; other site 1217737014223 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1217737014224 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1217737014225 FMN binding site [chemical binding]; other site 1217737014226 active site 1217737014227 catalytic residues [active] 1217737014228 substrate binding site [chemical binding]; other site 1217737014229 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1217737014230 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1217737014231 dimer interface [polypeptide binding]; other site 1217737014232 putative anticodon binding site; other site 1217737014233 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1217737014234 motif 1; other site 1217737014235 active site 1217737014236 motif 2; other site 1217737014237 motif 3; other site 1217737014238 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1217737014239 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1217737014240 UvrB/uvrC motif; Region: UVR; pfam02151 1217737014241 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1217737014242 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1217737014243 ADP binding site [chemical binding]; other site 1217737014244 phosphagen binding site; other site 1217737014245 substrate specificity loop; other site 1217737014246 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1217737014247 Clp amino terminal domain; Region: Clp_N; pfam02861 1217737014248 Clp amino terminal domain; Region: Clp_N; pfam02861 1217737014249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737014250 Walker A motif; other site 1217737014251 ATP binding site [chemical binding]; other site 1217737014252 Walker B motif; other site 1217737014253 arginine finger; other site 1217737014254 UvrB/uvrC motif; Region: UVR; pfam02151 1217737014255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737014256 Walker A motif; other site 1217737014257 ATP binding site [chemical binding]; other site 1217737014258 Walker B motif; other site 1217737014259 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1217737014260 DNA repair protein RadA; Provisional; Region: PRK11823 1217737014261 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1217737014262 Walker A motif/ATP binding site; other site 1217737014263 ATP binding site [chemical binding]; other site 1217737014264 Walker B motif; other site 1217737014265 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1217737014266 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1217737014267 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1217737014268 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1217737014269 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1217737014270 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1217737014271 putative active site [active] 1217737014272 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1217737014273 substrate binding site; other site 1217737014274 dimer interface; other site 1217737014275 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1217737014276 homotrimer interaction site [polypeptide binding]; other site 1217737014277 zinc binding site [ion binding]; other site 1217737014278 CDP-binding sites; other site 1217737014279 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1217737014280 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1217737014281 HIGH motif; other site 1217737014282 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1217737014283 active site 1217737014284 KMSKS motif; other site 1217737014285 serine O-acetyltransferase; Region: cysE; TIGR01172 1217737014286 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1217737014287 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1217737014288 trimer interface [polypeptide binding]; other site 1217737014289 active site 1217737014290 substrate binding site [chemical binding]; other site 1217737014291 CoA binding site [chemical binding]; other site 1217737014292 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1217737014293 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1217737014294 active site 1217737014295 HIGH motif; other site 1217737014296 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1217737014297 KMSKS motif; other site 1217737014298 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1217737014299 tRNA binding surface [nucleotide binding]; other site 1217737014300 anticodon binding site; other site 1217737014301 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1217737014302 active site 1217737014303 metal binding site [ion binding]; metal-binding site 1217737014304 dimerization interface [polypeptide binding]; other site 1217737014305 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1217737014306 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1217737014307 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1217737014308 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1217737014309 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 1217737014310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737014311 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1217737014312 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1217737014313 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1217737014314 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1217737014315 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1217737014316 putative homodimer interface [polypeptide binding]; other site 1217737014317 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1217737014318 heterodimer interface [polypeptide binding]; other site 1217737014319 homodimer interface [polypeptide binding]; other site 1217737014320 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1217737014321 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1217737014322 23S rRNA interface [nucleotide binding]; other site 1217737014323 L7/L12 interface [polypeptide binding]; other site 1217737014324 putative thiostrepton binding site; other site 1217737014325 L25 interface [polypeptide binding]; other site 1217737014326 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1217737014327 mRNA/rRNA interface [nucleotide binding]; other site 1217737014328 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1217737014329 23S rRNA interface [nucleotide binding]; other site 1217737014330 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1217737014331 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1217737014332 core dimer interface [polypeptide binding]; other site 1217737014333 peripheral dimer interface [polypeptide binding]; other site 1217737014334 L10 interface [polypeptide binding]; other site 1217737014335 L11 interface [polypeptide binding]; other site 1217737014336 putative EF-Tu interaction site [polypeptide binding]; other site 1217737014337 putative EF-G interaction site [polypeptide binding]; other site 1217737014338 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1217737014339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737014340 S-adenosylmethionine binding site [chemical binding]; other site 1217737014341 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 1217737014342 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1217737014343 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1217737014344 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1217737014345 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1217737014346 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1217737014347 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1217737014348 RPB10 interaction site [polypeptide binding]; other site 1217737014349 RPB1 interaction site [polypeptide binding]; other site 1217737014350 RPB11 interaction site [polypeptide binding]; other site 1217737014351 RPB3 interaction site [polypeptide binding]; other site 1217737014352 RPB12 interaction site [polypeptide binding]; other site 1217737014353 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1217737014354 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1217737014355 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1217737014356 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1217737014357 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1217737014358 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1217737014359 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1217737014360 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1217737014361 G-loop; other site 1217737014362 DNA binding site [nucleotide binding] 1217737014363 hypothetical protein; Provisional; Region: PRK06683 1217737014364 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1217737014365 S17 interaction site [polypeptide binding]; other site 1217737014366 S8 interaction site; other site 1217737014367 16S rRNA interaction site [nucleotide binding]; other site 1217737014368 streptomycin interaction site [chemical binding]; other site 1217737014369 23S rRNA interaction site [nucleotide binding]; other site 1217737014370 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1217737014371 30S ribosomal protein S7; Validated; Region: PRK05302 1217737014372 elongation factor G; Reviewed; Region: PRK00007 1217737014373 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1217737014374 G1 box; other site 1217737014375 putative GEF interaction site [polypeptide binding]; other site 1217737014376 GTP/Mg2+ binding site [chemical binding]; other site 1217737014377 Switch I region; other site 1217737014378 G2 box; other site 1217737014379 G3 box; other site 1217737014380 Switch II region; other site 1217737014381 G4 box; other site 1217737014382 G5 box; other site 1217737014383 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1217737014384 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1217737014385 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1217737014386 elongation factor Tu; Reviewed; Region: PRK00049 1217737014387 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1217737014388 G1 box; other site 1217737014389 GEF interaction site [polypeptide binding]; other site 1217737014390 GTP/Mg2+ binding site [chemical binding]; other site 1217737014391 Switch I region; other site 1217737014392 G2 box; other site 1217737014393 G3 box; other site 1217737014394 Switch II region; other site 1217737014395 G4 box; other site 1217737014396 G5 box; other site 1217737014397 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1217737014398 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1217737014399 Antibiotic Binding Site [chemical binding]; other site 1217737014400 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1217737014401 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1217737014402 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1217737014403 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1217737014404 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1217737014405 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1217737014406 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1217737014407 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1217737014408 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1217737014409 putative translocon binding site; other site 1217737014410 protein-rRNA interface [nucleotide binding]; other site 1217737014411 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1217737014412 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1217737014413 G-X-X-G motif; other site 1217737014414 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1217737014415 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1217737014416 23S rRNA interface [nucleotide binding]; other site 1217737014417 5S rRNA interface [nucleotide binding]; other site 1217737014418 putative antibiotic binding site [chemical binding]; other site 1217737014419 L25 interface [polypeptide binding]; other site 1217737014420 L27 interface [polypeptide binding]; other site 1217737014421 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1217737014422 23S rRNA interface [nucleotide binding]; other site 1217737014423 putative translocon interaction site; other site 1217737014424 signal recognition particle (SRP54) interaction site; other site 1217737014425 L23 interface [polypeptide binding]; other site 1217737014426 trigger factor interaction site; other site 1217737014427 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1217737014428 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1217737014429 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1217737014430 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1217737014431 RNA binding site [nucleotide binding]; other site 1217737014432 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1217737014433 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1217737014434 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1217737014435 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1217737014436 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1217737014437 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1217737014438 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1217737014439 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1217737014440 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1217737014441 5S rRNA interface [nucleotide binding]; other site 1217737014442 L27 interface [polypeptide binding]; other site 1217737014443 23S rRNA interface [nucleotide binding]; other site 1217737014444 L5 interface [polypeptide binding]; other site 1217737014445 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1217737014446 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1217737014447 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1217737014448 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1217737014449 23S rRNA binding site [nucleotide binding]; other site 1217737014450 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1217737014451 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 1217737014452 SecY translocase; Region: SecY; pfam00344 1217737014453 adenylate kinase; Reviewed; Region: adk; PRK00279 1217737014454 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1217737014455 AMP-binding site [chemical binding]; other site 1217737014456 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1217737014457 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1217737014458 active site 1217737014459 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1217737014460 rRNA binding site [nucleotide binding]; other site 1217737014461 predicted 30S ribosome binding site; other site 1217737014462 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1217737014463 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1217737014464 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1217737014465 30S ribosomal protein S11; Validated; Region: PRK05309 1217737014466 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1217737014467 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1217737014468 alphaNTD - beta interaction site [polypeptide binding]; other site 1217737014469 alphaNTD homodimer interface [polypeptide binding]; other site 1217737014470 alphaNTD - beta' interaction site [polypeptide binding]; other site 1217737014471 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1217737014472 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1217737014473 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1217737014474 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1217737014475 Walker A/P-loop; other site 1217737014476 ATP binding site [chemical binding]; other site 1217737014477 Q-loop/lid; other site 1217737014478 ABC transporter signature motif; other site 1217737014479 Walker B; other site 1217737014480 D-loop; other site 1217737014481 H-loop/switch region; other site 1217737014482 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1217737014483 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1217737014484 Walker A/P-loop; other site 1217737014485 ATP binding site [chemical binding]; other site 1217737014486 Q-loop/lid; other site 1217737014487 ABC transporter signature motif; other site 1217737014488 Walker B; other site 1217737014489 D-loop; other site 1217737014490 H-loop/switch region; other site 1217737014491 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1217737014492 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1217737014493 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1217737014494 dimerization interface 3.5A [polypeptide binding]; other site 1217737014495 active site 1217737014496 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1217737014497 23S rRNA interface [nucleotide binding]; other site 1217737014498 L3 interface [polypeptide binding]; other site 1217737014499 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1217737014500 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1217737014501 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737014502 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737014503 active site 1217737014504 metal binding site [ion binding]; metal-binding site 1217737014505 Domain of unknown function DUF59; Region: DUF59; cl00941 1217737014506 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1217737014507 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1217737014508 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1217737014509 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737014510 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1217737014511 NodB motif; other site 1217737014512 putative active site [active] 1217737014513 putative catalytic site [active] 1217737014514 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1217737014515 Arginase family; Region: Arginase; cd09989 1217737014516 agmatinase; Region: agmatinase; TIGR01230 1217737014517 active site 1217737014518 Mn binding site [ion binding]; other site 1217737014519 oligomer interface [polypeptide binding]; other site 1217737014520 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1217737014521 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1217737014522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1217737014523 YbbR-like protein; Region: YbbR; pfam07949 1217737014524 YbbR-like protein; Region: YbbR; pfam07949 1217737014525 YbbR-like protein; Region: YbbR; pfam07949 1217737014526 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1217737014527 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1217737014528 active site 1217737014529 substrate binding site [chemical binding]; other site 1217737014530 metal binding site [ion binding]; metal-binding site 1217737014531 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1217737014532 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1217737014533 glutaminase active site [active] 1217737014534 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1217737014535 dimer interface [polypeptide binding]; other site 1217737014536 active site 1217737014537 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1217737014538 dimer interface [polypeptide binding]; other site 1217737014539 active site 1217737014540 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1217737014541 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737014542 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1217737014543 DoxX; Region: DoxX; cl17842 1217737014544 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 1217737014545 classical (c) SDRs; Region: SDR_c; cd05233 1217737014546 NAD(P) binding site [chemical binding]; other site 1217737014547 active site 1217737014548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737014549 ABC-ATPase subunit interface; other site 1217737014550 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1217737014551 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1217737014552 Walker A/P-loop; other site 1217737014553 ATP binding site [chemical binding]; other site 1217737014554 Q-loop/lid; other site 1217737014555 ABC transporter signature motif; other site 1217737014556 Walker B; other site 1217737014557 D-loop; other site 1217737014558 H-loop/switch region; other site 1217737014559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1217737014560 NIL domain; Region: NIL; pfam09383 1217737014561 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1217737014562 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1217737014563 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1217737014564 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1217737014565 putative NAD(P) binding site [chemical binding]; other site 1217737014566 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1217737014567 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737014568 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1217737014569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737014570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737014571 putative substrate translocation pore; other site 1217737014572 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 1217737014573 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1217737014574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737014575 putative substrate translocation pore; other site 1217737014576 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 1217737014577 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 1217737014578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1217737014579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737014580 dimer interface [polypeptide binding]; other site 1217737014581 conserved gate region; other site 1217737014582 putative PBP binding loops; other site 1217737014583 ABC-ATPase subunit interface; other site 1217737014584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1217737014585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737014586 dimer interface [polypeptide binding]; other site 1217737014587 conserved gate region; other site 1217737014588 putative PBP binding loops; other site 1217737014589 ABC-ATPase subunit interface; other site 1217737014590 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1217737014591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737014592 Walker A/P-loop; other site 1217737014593 ATP binding site [chemical binding]; other site 1217737014594 Q-loop/lid; other site 1217737014595 ABC transporter signature motif; other site 1217737014596 Walker B; other site 1217737014597 D-loop; other site 1217737014598 H-loop/switch region; other site 1217737014599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1217737014600 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1217737014601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737014602 Walker A/P-loop; other site 1217737014603 ATP binding site [chemical binding]; other site 1217737014604 Q-loop/lid; other site 1217737014605 ABC transporter signature motif; other site 1217737014606 Walker B; other site 1217737014607 D-loop; other site 1217737014608 H-loop/switch region; other site 1217737014609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1217737014610 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737014611 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737014612 peptide binding site [polypeptide binding]; other site 1217737014613 YusW-like protein; Region: YusW; pfam14039 1217737014614 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737014615 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737014616 peptide binding site [polypeptide binding]; other site 1217737014617 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1217737014618 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1217737014619 peptide binding site [polypeptide binding]; other site 1217737014620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1217737014621 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1217737014622 active site 1217737014623 catalytic tetrad [active] 1217737014624 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 1217737014625 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1217737014626 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1217737014627 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1217737014628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737014629 dimer interface [polypeptide binding]; other site 1217737014630 conserved gate region; other site 1217737014631 putative PBP binding loops; other site 1217737014632 ABC-ATPase subunit interface; other site 1217737014633 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1217737014634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1217737014635 dimerization interface [polypeptide binding]; other site 1217737014636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737014637 membrane-bound complex binding site; other site 1217737014638 hinge residues; other site 1217737014639 DNA binding domain, excisionase family; Region: excise; TIGR01764 1217737014640 PBP superfamily domain; Region: PBP_like; pfam12727 1217737014641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737014642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737014643 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1217737014644 putative dimerization interface [polypeptide binding]; other site 1217737014645 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737014646 EamA-like transporter family; Region: EamA; pfam00892 1217737014647 YrzO-like protein; Region: YrzO; pfam14142 1217737014648 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1217737014649 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1217737014650 putative acyl-acceptor binding pocket; other site 1217737014651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1217737014652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1217737014653 DNA binding site [nucleotide binding] 1217737014654 domain linker motif; other site 1217737014655 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1217737014656 putative ligand binding site [chemical binding]; other site 1217737014657 putative dimerization interface [polypeptide binding]; other site 1217737014658 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1217737014659 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737014660 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1217737014661 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1217737014662 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1217737014663 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1217737014664 active site 1217737014665 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1217737014666 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1217737014667 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1217737014668 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1217737014669 catalytic residue [active] 1217737014670 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1217737014671 nucleotide binding site/active site [active] 1217737014672 HIT family signature motif; other site 1217737014673 catalytic residue [active] 1217737014674 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737014675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737014676 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737014677 ABC transporter; Region: ABC_tran_2; pfam12848 1217737014678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737014679 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1217737014680 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1217737014681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1217737014682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737014683 dimer interface [polypeptide binding]; other site 1217737014684 conserved gate region; other site 1217737014685 putative PBP binding loops; other site 1217737014686 ABC-ATPase subunit interface; other site 1217737014687 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1217737014688 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1217737014689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737014690 dimer interface [polypeptide binding]; other site 1217737014691 conserved gate region; other site 1217737014692 putative PBP binding loops; other site 1217737014693 ABC-ATPase subunit interface; other site 1217737014694 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1217737014695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737014696 Walker A/P-loop; other site 1217737014697 ATP binding site [chemical binding]; other site 1217737014698 Q-loop/lid; other site 1217737014699 ABC transporter signature motif; other site 1217737014700 Walker B; other site 1217737014701 D-loop; other site 1217737014702 H-loop/switch region; other site 1217737014703 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1217737014704 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1217737014705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1217737014706 Walker A/P-loop; other site 1217737014707 ATP binding site [chemical binding]; other site 1217737014708 Q-loop/lid; other site 1217737014709 ABC transporter signature motif; other site 1217737014710 Walker B; other site 1217737014711 D-loop; other site 1217737014712 H-loop/switch region; other site 1217737014713 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1217737014714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737014715 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1217737014716 active site 1217737014717 motif I; other site 1217737014718 motif II; other site 1217737014719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737014720 motif II; other site 1217737014721 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1217737014722 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1217737014723 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1217737014724 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1217737014725 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1217737014726 dimer interface [polypeptide binding]; other site 1217737014727 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1217737014728 active site 1217737014729 Fe binding site [ion binding]; other site 1217737014730 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1217737014731 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1217737014732 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1217737014733 amino acid transporter; Region: 2A0306; TIGR00909 1217737014734 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1217737014735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737014736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737014737 putative substrate translocation pore; other site 1217737014738 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1217737014739 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1217737014740 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1217737014741 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1217737014742 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1217737014743 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1217737014744 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1217737014745 helicase 45; Provisional; Region: PTZ00424 1217737014746 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1217737014747 ATP binding site [chemical binding]; other site 1217737014748 Mg++ binding site [ion binding]; other site 1217737014749 motif III; other site 1217737014750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737014751 nucleotide binding region [chemical binding]; other site 1217737014752 ATP-binding site [chemical binding]; other site 1217737014753 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1217737014754 Rhomboid family; Region: Rhomboid; pfam01694 1217737014755 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1217737014756 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1217737014757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1217737014758 alanine racemase; Reviewed; Region: alr; PRK00053 1217737014759 active site 1217737014760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1217737014761 dimer interface [polypeptide binding]; other site 1217737014762 substrate binding site [chemical binding]; other site 1217737014763 catalytic residues [active] 1217737014764 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1217737014765 PemK-like protein; Region: PemK; pfam02452 1217737014766 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1217737014767 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1217737014768 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1217737014769 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1217737014770 RNA binding site [nucleotide binding]; other site 1217737014771 hypothetical protein; Provisional; Region: PRK04351 1217737014772 SprT homologues; Region: SprT; cl01182 1217737014773 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1217737014774 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1217737014775 Glycoprotease family; Region: Peptidase_M22; pfam00814 1217737014776 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1217737014777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1217737014778 Coenzyme A binding pocket [chemical binding]; other site 1217737014779 UGMP family protein; Validated; Region: PRK09604 1217737014780 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1217737014781 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1217737014782 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737014783 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737014784 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737014785 ABC transporter; Region: ABC_tran_2; pfam12848 1217737014786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737014787 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1217737014788 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1217737014789 CoA binding domain; Region: CoA_binding; pfam02629 1217737014790 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1217737014791 CAAX protease self-immunity; Region: Abi; pfam02517 1217737014792 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1217737014793 oligomerisation interface [polypeptide binding]; other site 1217737014794 mobile loop; other site 1217737014795 roof hairpin; other site 1217737014796 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1217737014797 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1217737014798 ring oligomerisation interface [polypeptide binding]; other site 1217737014799 ATP/Mg binding site [chemical binding]; other site 1217737014800 stacking interactions; other site 1217737014801 hinge regions; other site 1217737014802 integrase; Provisional; Region: int; PHA02601 1217737014803 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1217737014804 Int/Topo IB signature motif; other site 1217737014805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737014806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737014807 non-specific DNA binding site [nucleotide binding]; other site 1217737014808 salt bridge; other site 1217737014809 sequence-specific DNA binding site [nucleotide binding]; other site 1217737014810 Helix-turn-helix domain; Region: HTH_17; pfam12728 1217737014811 Uncharacterized conserved protein [Function unknown]; Region: COG4983 1217737014812 Domain of unknown function (DUF927); Region: DUF927; cl12098 1217737014813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1217737014814 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1217737014815 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737014816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737014817 non-specific DNA binding site [nucleotide binding]; other site 1217737014818 salt bridge; other site 1217737014819 sequence-specific DNA binding site [nucleotide binding]; other site 1217737014820 Domain of unknown function (DUF955); Region: DUF955; cl01076 1217737014821 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737014822 LXG domain of WXG superfamily; Region: LXG; pfam04740 1217737014823 Helix-turn-helix domain; Region: HTH_17; pfam12728 1217737014824 GMP synthase; Reviewed; Region: guaA; PRK00074 1217737014825 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1217737014826 AMP/PPi binding site [chemical binding]; other site 1217737014827 candidate oxyanion hole; other site 1217737014828 catalytic triad [active] 1217737014829 potential glutamine specificity residues [chemical binding]; other site 1217737014830 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1217737014831 ATP Binding subdomain [chemical binding]; other site 1217737014832 Ligand Binding sites [chemical binding]; other site 1217737014833 Dimerization subdomain; other site 1217737014834 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1217737014835 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737014836 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1217737014837 Replication initiation factor; Region: Rep_trans; pfam02486 1217737014838 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1217737014839 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1217737014840 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1217737014841 Int/Topo IB signature motif; other site 1217737014842 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1217737014843 active site 1217737014844 metal binding site [ion binding]; metal-binding site 1217737014845 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1217737014846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737014847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737014848 active site 1217737014849 phosphorylation site [posttranslational modification] 1217737014850 intermolecular recognition site; other site 1217737014851 dimerization interface [polypeptide binding]; other site 1217737014852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737014853 DNA binding site [nucleotide binding] 1217737014854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737014855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1217737014856 dimerization interface [polypeptide binding]; other site 1217737014857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737014858 dimer interface [polypeptide binding]; other site 1217737014859 phosphorylation site [posttranslational modification] 1217737014860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737014861 ATP binding site [chemical binding]; other site 1217737014862 Mg2+ binding site [ion binding]; other site 1217737014863 G-X-G motif; other site 1217737014864 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1217737014865 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737014866 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1217737014867 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1217737014868 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1217737014869 catalytic residues [active] 1217737014870 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1217737014871 potential frameshift: common BLAST hit: gi|218895386|ref|YP_002443797.1| proline dehydrogenase 1217737014872 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1217737014873 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1217737014874 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1217737014875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1217737014876 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1217737014877 Walker A/P-loop; other site 1217737014878 ATP binding site [chemical binding]; other site 1217737014879 Q-loop/lid; other site 1217737014880 ABC transporter signature motif; other site 1217737014881 Walker B; other site 1217737014882 D-loop; other site 1217737014883 H-loop/switch region; other site 1217737014884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737014885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737014886 dimer interface [polypeptide binding]; other site 1217737014887 phosphorylation site [posttranslational modification] 1217737014888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737014889 ATP binding site [chemical binding]; other site 1217737014890 Mg2+ binding site [ion binding]; other site 1217737014891 G-X-G motif; other site 1217737014892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737014893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737014894 active site 1217737014895 phosphorylation site [posttranslational modification] 1217737014896 intermolecular recognition site; other site 1217737014897 dimerization interface [polypeptide binding]; other site 1217737014898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737014899 DNA binding site [nucleotide binding] 1217737014900 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1217737014901 EamA-like transporter family; Region: EamA; pfam00892 1217737014902 EamA-like transporter family; Region: EamA; pfam00892 1217737014903 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1217737014904 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1217737014905 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1217737014906 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1217737014907 NAD binding site [chemical binding]; other site 1217737014908 ATP-grasp domain; Region: ATP-grasp; pfam02222 1217737014909 adenylosuccinate lyase; Provisional; Region: PRK07492 1217737014910 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1217737014911 tetramer interface [polypeptide binding]; other site 1217737014912 active site 1217737014913 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1217737014914 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1217737014915 ATP binding site [chemical binding]; other site 1217737014916 active site 1217737014917 substrate binding site [chemical binding]; other site 1217737014918 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1217737014919 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1217737014920 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1217737014921 putative active site [active] 1217737014922 catalytic triad [active] 1217737014923 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1217737014924 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1217737014925 dimerization interface [polypeptide binding]; other site 1217737014926 ATP binding site [chemical binding]; other site 1217737014927 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1217737014928 dimerization interface [polypeptide binding]; other site 1217737014929 ATP binding site [chemical binding]; other site 1217737014930 amidophosphoribosyltransferase; Provisional; Region: PRK06781 1217737014931 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1217737014932 active site 1217737014933 tetramer interface [polypeptide binding]; other site 1217737014934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737014935 active site 1217737014936 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1217737014937 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1217737014938 dimerization interface [polypeptide binding]; other site 1217737014939 putative ATP binding site [chemical binding]; other site 1217737014940 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1217737014941 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1217737014942 active site 1217737014943 substrate binding site [chemical binding]; other site 1217737014944 cosubstrate binding site; other site 1217737014945 catalytic site [active] 1217737014946 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1217737014947 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1217737014948 purine monophosphate binding site [chemical binding]; other site 1217737014949 dimer interface [polypeptide binding]; other site 1217737014950 putative catalytic residues [active] 1217737014951 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1217737014952 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1217737014953 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1217737014954 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1217737014955 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1217737014956 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1217737014957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1217737014958 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1217737014959 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1217737014960 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1217737014961 PcrB family; Region: PcrB; pfam01884 1217737014962 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1217737014963 substrate binding site [chemical binding]; other site 1217737014964 putative active site [active] 1217737014965 dimer interface [polypeptide binding]; other site 1217737014966 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1217737014967 Part of AAA domain; Region: AAA_19; pfam13245 1217737014968 Family description; Region: UvrD_C_2; pfam13538 1217737014969 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1217737014970 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1217737014971 nucleotide binding pocket [chemical binding]; other site 1217737014972 K-X-D-G motif; other site 1217737014973 catalytic site [active] 1217737014974 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1217737014975 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1217737014976 Dimer interface [polypeptide binding]; other site 1217737014977 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1217737014978 putative dimer interface [polypeptide binding]; other site 1217737014979 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1217737014980 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1217737014981 putative dimer interface [polypeptide binding]; other site 1217737014982 hypothetical protein; Provisional; Region: PRK10621 1217737014983 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1217737014984 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1217737014985 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1217737014986 Glutamate binding site [chemical binding]; other site 1217737014987 homodimer interface [polypeptide binding]; other site 1217737014988 NAD binding site [chemical binding]; other site 1217737014989 catalytic residues [active] 1217737014990 Isochorismatase family; Region: Isochorismatase; pfam00857 1217737014991 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1217737014992 catalytic triad [active] 1217737014993 conserved cis-peptide bond; other site 1217737014994 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1217737014995 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1217737014996 Walker A/P-loop; other site 1217737014997 ATP binding site [chemical binding]; other site 1217737014998 Q-loop/lid; other site 1217737014999 ABC transporter signature motif; other site 1217737015000 Walker B; other site 1217737015001 D-loop; other site 1217737015002 H-loop/switch region; other site 1217737015003 NIL domain; Region: NIL; pfam09383 1217737015004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737015005 dimer interface [polypeptide binding]; other site 1217737015006 conserved gate region; other site 1217737015007 ABC-ATPase subunit interface; other site 1217737015008 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1217737015009 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1217737015010 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1217737015011 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 1217737015012 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1217737015013 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1217737015014 P loop; other site 1217737015015 Nucleotide binding site [chemical binding]; other site 1217737015016 DTAP/Switch II; other site 1217737015017 Switch I; other site 1217737015018 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1217737015019 putative dimer interface [polypeptide binding]; other site 1217737015020 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1217737015021 MarR family; Region: MarR; pfam01047 1217737015022 MarR family; Region: MarR_2; cl17246 1217737015023 yiaA/B two helix domain; Region: YiaAB; pfam05360 1217737015024 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1217737015025 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1217737015026 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1217737015027 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1217737015028 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1217737015029 GatB domain; Region: GatB_Yqey; pfam02637 1217737015030 putative lipid kinase; Reviewed; Region: PRK13337 1217737015031 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1217737015032 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1217737015033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1217737015034 motif II; other site 1217737015035 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1217737015036 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1217737015037 inhibitor-cofactor binding pocket; inhibition site 1217737015038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737015039 catalytic residue [active] 1217737015040 PAS domain; Region: PAS_9; pfam13426 1217737015041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1217737015042 putative active site [active] 1217737015043 heme pocket [chemical binding]; other site 1217737015044 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1217737015045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737015046 Walker A motif; other site 1217737015047 ATP binding site [chemical binding]; other site 1217737015048 Walker B motif; other site 1217737015049 arginine finger; other site 1217737015050 succinic semialdehyde dehydrogenase; Region: PLN02278 1217737015051 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1217737015052 tetramerization interface [polypeptide binding]; other site 1217737015053 NAD(P) binding site [chemical binding]; other site 1217737015054 catalytic residues [active] 1217737015055 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1217737015056 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1217737015057 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1217737015058 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1217737015059 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1217737015060 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1217737015061 putative active site [active] 1217737015062 putative metal binding site [ion binding]; other site 1217737015063 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737015064 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737015065 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737015066 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1217737015067 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1217737015068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737015069 S-adenosylmethionine binding site [chemical binding]; other site 1217737015070 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1217737015071 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1217737015072 FMN binding site [chemical binding]; other site 1217737015073 active site 1217737015074 catalytic residues [active] 1217737015075 substrate binding site [chemical binding]; other site 1217737015076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1217737015077 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1217737015078 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1217737015079 Protein of unknown function DUF45; Region: DUF45; pfam01863 1217737015080 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1217737015081 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1217737015082 active site 1217737015083 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1217737015084 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1217737015085 amidohydrolase; Region: amidohydrolases; TIGR01891 1217737015086 metal binding site [ion binding]; metal-binding site 1217737015087 putative dimer interface [polypeptide binding]; other site 1217737015088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1217737015089 S-adenosylmethionine binding site [chemical binding]; other site 1217737015090 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1217737015091 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1217737015092 catalytic residue [active] 1217737015093 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1217737015094 catalytic residues [active] 1217737015095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737015096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1217737015097 peroxiredoxin; Region: AhpC; TIGR03137 1217737015098 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1217737015099 dimer interface [polypeptide binding]; other site 1217737015100 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1217737015101 catalytic triad [active] 1217737015102 peroxidatic and resolving cysteines [active] 1217737015103 5-methylribose kinase; Reviewed; Region: PRK12396 1217737015104 Phosphotransferase enzyme family; Region: APH; pfam01636 1217737015105 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1217737015106 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1217737015107 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 1217737015108 intersubunit interface [polypeptide binding]; other site 1217737015109 active site 1217737015110 Zn2+ binding site [ion binding]; other site 1217737015111 putative transposase OrfB; Reviewed; Region: PHA02517 1217737015112 HTH-like domain; Region: HTH_21; pfam13276 1217737015113 Integrase core domain; Region: rve; pfam00665 1217737015114 Integrase core domain; Region: rve_2; pfam13333 1217737015115 Homeodomain-like domain; Region: HTH_23; cl17451 1217737015116 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1217737015117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737015118 ABC-ATPase subunit interface; other site 1217737015119 dimer interface [polypeptide binding]; other site 1217737015120 putative PBP binding regions; other site 1217737015121 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1217737015122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1217737015123 ABC-ATPase subunit interface; other site 1217737015124 dimer interface [polypeptide binding]; other site 1217737015125 putative PBP binding regions; other site 1217737015126 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1217737015127 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1217737015128 putative ligand binding residues [chemical binding]; other site 1217737015129 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1217737015130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1217737015131 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1217737015132 DNA binding domain, excisionase family; Region: excise; TIGR01764 1217737015133 Sm and related proteins; Region: Sm_like; cl00259 1217737015134 Sm1 motif; other site 1217737015135 RNA binding site [nucleotide binding]; other site 1217737015136 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1217737015137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737015138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737015139 dimer interface [polypeptide binding]; other site 1217737015140 phosphorylation site [posttranslational modification] 1217737015141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737015142 ATP binding site [chemical binding]; other site 1217737015143 Mg2+ binding site [ion binding]; other site 1217737015144 G-X-G motif; other site 1217737015145 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1217737015146 hypothetical protein; Provisional; Region: PRK06851 1217737015147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737015148 Walker A motif; other site 1217737015149 ATP binding site [chemical binding]; other site 1217737015150 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1217737015151 benzoate transport; Region: 2A0115; TIGR00895 1217737015152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737015153 putative substrate translocation pore; other site 1217737015154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737015155 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1217737015156 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1217737015157 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1217737015158 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1217737015159 [2Fe-2S] cluster binding site [ion binding]; other site 1217737015160 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1217737015161 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1217737015162 putative di-iron ligands [ion binding]; other site 1217737015163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737015164 dimer interface [polypeptide binding]; other site 1217737015165 conserved gate region; other site 1217737015166 putative PBP binding loops; other site 1217737015167 ABC-ATPase subunit interface; other site 1217737015168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1217737015169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1217737015170 substrate binding pocket [chemical binding]; other site 1217737015171 membrane-bound complex binding site; other site 1217737015172 hinge residues; other site 1217737015173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1217737015174 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1217737015175 Walker A/P-loop; other site 1217737015176 ATP binding site [chemical binding]; other site 1217737015177 Q-loop/lid; other site 1217737015178 ABC transporter signature motif; other site 1217737015179 Walker B; other site 1217737015180 D-loop; other site 1217737015181 H-loop/switch region; other site 1217737015182 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1217737015183 HAMP domain; Region: HAMP; pfam00672 1217737015184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737015185 dimer interface [polypeptide binding]; other site 1217737015186 putative CheW interface [polypeptide binding]; other site 1217737015187 Arginine repressor [Transcription]; Region: ArgR; COG1438 1217737015188 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1217737015189 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1217737015190 arginine deiminase; Provisional; Region: PRK01388 1217737015191 ornithine carbamoyltransferase; Validated; Region: PRK02102 1217737015192 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1217737015193 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1217737015194 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1217737015195 carbamate kinase; Reviewed; Region: PRK12686 1217737015196 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1217737015197 putative substrate binding site [chemical binding]; other site 1217737015198 nucleotide binding site [chemical binding]; other site 1217737015199 nucleotide binding site [chemical binding]; other site 1217737015200 homodimer interface [polypeptide binding]; other site 1217737015201 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1217737015202 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1217737015203 ligand binding site [chemical binding]; other site 1217737015204 flexible hinge region; other site 1217737015205 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1217737015206 putative switch regulator; other site 1217737015207 non-specific DNA interactions [nucleotide binding]; other site 1217737015208 DNA binding site [nucleotide binding] 1217737015209 sequence specific DNA binding site [nucleotide binding]; other site 1217737015210 putative cAMP binding site [chemical binding]; other site 1217737015211 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1217737015212 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1217737015213 FAD binding domain; Region: FAD_binding_4; pfam01565 1217737015214 Berberine and berberine like; Region: BBE; pfam08031 1217737015215 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1217737015216 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1217737015217 Ca binding site [ion binding]; other site 1217737015218 active site 1217737015219 catalytic site [active] 1217737015220 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1217737015221 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1217737015222 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1217737015223 active site turn [active] 1217737015224 phosphorylation site [posttranslational modification] 1217737015225 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1217737015226 putative catalytic site [active] 1217737015227 putative metal binding site [ion binding]; other site 1217737015228 putative phosphate binding site [ion binding]; other site 1217737015229 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1217737015230 Predicted membrane protein [Function unknown]; Region: COG1511 1217737015231 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1217737015232 DNA topoisomerase III; Provisional; Region: PRK07726 1217737015233 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1217737015234 active site 1217737015235 putative interdomain interaction site [polypeptide binding]; other site 1217737015236 putative metal-binding site [ion binding]; other site 1217737015237 putative nucleotide binding site [chemical binding]; other site 1217737015238 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1217737015239 domain I; other site 1217737015240 DNA binding groove [nucleotide binding] 1217737015241 phosphate binding site [ion binding]; other site 1217737015242 domain II; other site 1217737015243 domain III; other site 1217737015244 nucleotide binding site [chemical binding]; other site 1217737015245 catalytic site [active] 1217737015246 domain IV; other site 1217737015247 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1217737015248 substrate binding site [chemical binding]; other site 1217737015249 multimerization interface [polypeptide binding]; other site 1217737015250 ATP binding site [chemical binding]; other site 1217737015251 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1217737015252 thiamine phosphate binding site [chemical binding]; other site 1217737015253 active site 1217737015254 pyrophosphate binding site [ion binding]; other site 1217737015255 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1217737015256 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1217737015257 HAMP domain; Region: HAMP; pfam00672 1217737015258 dimerization interface [polypeptide binding]; other site 1217737015259 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1217737015260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1217737015261 dimer interface [polypeptide binding]; other site 1217737015262 putative CheW interface [polypeptide binding]; other site 1217737015263 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1217737015264 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1217737015265 acyl-activating enzyme (AAE) consensus motif; other site 1217737015266 AMP binding site [chemical binding]; other site 1217737015267 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1217737015268 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1217737015269 putative NAD(P) binding site [chemical binding]; other site 1217737015270 active site 1217737015271 putative substrate binding site [chemical binding]; other site 1217737015272 Domain of unknown function DUF77; Region: DUF77; pfam01910 1217737015273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1217737015274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1217737015275 dimer interface [polypeptide binding]; other site 1217737015276 conserved gate region; other site 1217737015277 putative PBP binding loops; other site 1217737015278 ABC-ATPase subunit interface; other site 1217737015279 NMT1/THI5 like; Region: NMT1; pfam09084 1217737015280 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1217737015281 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1217737015282 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1217737015283 Walker A/P-loop; other site 1217737015284 ATP binding site [chemical binding]; other site 1217737015285 Q-loop/lid; other site 1217737015286 ABC transporter signature motif; other site 1217737015287 Walker B; other site 1217737015288 D-loop; other site 1217737015289 H-loop/switch region; other site 1217737015290 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1217737015291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737015292 Walker A/P-loop; other site 1217737015293 ATP binding site [chemical binding]; other site 1217737015294 Q-loop/lid; other site 1217737015295 ABC transporter signature motif; other site 1217737015296 Walker B; other site 1217737015297 D-loop; other site 1217737015298 H-loop/switch region; other site 1217737015299 ABC transporter; Region: ABC_tran_2; pfam12848 1217737015300 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1217737015301 Glyco_18 domain; Region: Glyco_18; smart00636 1217737015302 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1217737015303 active site 1217737015304 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1217737015305 Interdomain contacts; other site 1217737015306 Cytokine receptor motif; other site 1217737015307 Cellulose binding domain; Region: CBM_2; pfam00553 1217737015308 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1217737015309 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737015310 catalytic residues [active] 1217737015311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737015312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737015313 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1217737015314 H+ Antiporter protein; Region: 2A0121; TIGR00900 1217737015315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737015316 putative substrate translocation pore; other site 1217737015317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015318 non-specific DNA binding site [nucleotide binding]; other site 1217737015319 salt bridge; other site 1217737015320 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015321 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1217737015322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737015323 putative substrate translocation pore; other site 1217737015324 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1217737015325 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1217737015326 YesK-like protein; Region: YesK; pfam14150 1217737015327 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1217737015328 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1217737015329 dimer interface [polypeptide binding]; other site 1217737015330 motif 1; other site 1217737015331 active site 1217737015332 motif 2; other site 1217737015333 motif 3; other site 1217737015334 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1217737015335 anticodon binding site; other site 1217737015336 zinc-binding site [ion binding]; other site 1217737015337 enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase; Region: PLN02664 1217737015338 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1217737015339 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1217737015340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1217737015341 Baseplate J-like protein; Region: Baseplate_J; pfam04865 1217737015342 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737015343 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737015344 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1217737015345 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1217737015346 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1217737015347 catalytic residue [active] 1217737015348 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737015349 amidase catalytic site [active] 1217737015350 Zn binding residues [ion binding]; other site 1217737015351 substrate binding site [chemical binding]; other site 1217737015352 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1217737015353 Catalytic site; other site 1217737015354 Bacterial Ig-like domain; Region: Big_5; pfam13205 1217737015355 Phage capsid family; Region: Phage_capsid; pfam05065 1217737015356 Phage portal protein; Region: Phage_portal; pfam04860 1217737015357 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1217737015358 thioester formation/cholesterol transfer; other site 1217737015359 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1217737015360 Terminase-like family; Region: Terminase_6; pfam03237 1217737015361 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1217737015362 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 1217737015363 AAA domain; Region: AAA_30; pfam13604 1217737015364 Family description; Region: UvrD_C_2; pfam13538 1217737015365 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1217737015366 active site 1217737015367 NTP binding site [chemical binding]; other site 1217737015368 metal binding triad [ion binding]; metal-binding site 1217737015369 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1217737015370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737015371 Zn2+ binding site [ion binding]; other site 1217737015372 Mg2+ binding site [ion binding]; other site 1217737015373 SpoVG; Region: SpoVG; pfam04026 1217737015374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1217737015375 nucleotide binding site [chemical binding]; other site 1217737015376 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1217737015377 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1217737015378 Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460 1217737015379 PRTRC system protein A; Region: PRTRC_A; TIGR03735 1217737015380 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1217737015381 ATP binding site [chemical binding]; other site 1217737015382 substrate interface [chemical binding]; other site 1217737015383 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1217737015384 RNA/DNA hybrid binding site [nucleotide binding]; other site 1217737015385 active site 1217737015386 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1217737015387 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1217737015388 active site 1217737015389 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1217737015390 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1217737015391 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1217737015392 generic binding surface I; other site 1217737015393 generic binding surface II; other site 1217737015394 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1217737015395 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1217737015396 nucleotide binding pocket [chemical binding]; other site 1217737015397 K-X-D-G motif; other site 1217737015398 catalytic site [active] 1217737015399 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1217737015400 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1217737015401 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1217737015402 Dimer interface [polypeptide binding]; other site 1217737015403 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1217737015404 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1217737015405 active site 1217737015406 NTP binding site [chemical binding]; other site 1217737015407 nucleic acid binding site [nucleotide binding]; other site 1217737015408 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1217737015409 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1217737015410 putative active site [active] 1217737015411 putative NTP binding site [chemical binding]; other site 1217737015412 putative nucleic acid binding site [nucleotide binding]; other site 1217737015413 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1217737015414 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1217737015415 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1217737015416 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1217737015417 ADP-ribose binding site [chemical binding]; other site 1217737015418 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 1217737015419 GIY-YIG motif/motif A; other site 1217737015420 putative active site [active] 1217737015421 putative metal binding site [ion binding]; other site 1217737015422 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1217737015423 Thg1 C terminal domain; Region: Thg1C; pfam14413 1217737015424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1217737015425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1217737015426 TPR motif; other site 1217737015427 binding surface 1217737015428 Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460 1217737015429 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1217737015430 ATP binding site [chemical binding]; other site 1217737015431 substrate interface [chemical binding]; other site 1217737015432 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737015433 amidase catalytic site [active] 1217737015434 Zn binding residues [ion binding]; other site 1217737015435 substrate binding site [chemical binding]; other site 1217737015436 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737015437 potential protein location (hypothetical protein BTF1_31232 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-S) 1217737015438 potential protein location (hypothetical protein BTF1_31232 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-W) 1217737015439 potential protein location (hypothetical protein BTF1_31232 [Bacillus thuringiensis HD-789]) that overlaps RNA (tRNA-Y) 1217737015440 thymidine kinase; Provisional; Region: PRK04296 1217737015441 Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431 1217737015442 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1217737015443 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1217737015444 dimer interface [polypeptide binding]; other site 1217737015445 ssDNA binding site [nucleotide binding]; other site 1217737015446 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1217737015447 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1217737015448 Walker A motif; other site 1217737015449 ATP binding site [chemical binding]; other site 1217737015450 Walker B motif; other site 1217737015451 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1217737015452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1217737015453 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1217737015454 Walker A motif; other site 1217737015455 ATP binding site [chemical binding]; other site 1217737015456 Walker B motif; other site 1217737015457 arginine finger; other site 1217737015458 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1217737015459 dimerization interface [polypeptide binding]; other site 1217737015460 active site 1217737015461 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1217737015462 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1217737015463 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1217737015464 folate binding site [chemical binding]; other site 1217737015465 NADP+ binding site [chemical binding]; other site 1217737015466 chaperone protein DnaJ; Provisional; Region: PRK14287 1217737015467 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 1217737015468 Phage lysis protein, holin; Region: Phage_holin; cl04675 1217737015469 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1217737015470 Part of AAA domain; Region: AAA_19; pfam13245 1217737015471 Family description; Region: UvrD_C_2; pfam13538 1217737015472 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1217737015473 trimer interface [polypeptide binding]; other site 1217737015474 active site 1217737015475 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1217737015476 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1217737015477 TMP-binding site; other site 1217737015478 ATP-binding site [chemical binding]; other site 1217737015479 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1217737015480 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1217737015481 3D domain; Region: 3D; cl01439 1217737015482 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1217737015483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737015484 ATP binding site [chemical binding]; other site 1217737015485 putative Mg++ binding site [ion binding]; other site 1217737015486 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1217737015487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737015488 nucleotide binding region [chemical binding]; other site 1217737015489 ATP-binding site [chemical binding]; other site 1217737015490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1217737015491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1217737015492 active site 1217737015493 phosphorylation site [posttranslational modification] 1217737015494 intermolecular recognition site; other site 1217737015495 dimerization interface [polypeptide binding]; other site 1217737015496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1217737015497 DNA binding site [nucleotide binding] 1217737015498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737015499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737015500 dimer interface [polypeptide binding]; other site 1217737015501 phosphorylation site [posttranslational modification] 1217737015502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737015503 ATP binding site [chemical binding]; other site 1217737015504 Mg2+ binding site [ion binding]; other site 1217737015505 G-X-G motif; other site 1217737015506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1217737015507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1217737015508 dimer interface [polypeptide binding]; other site 1217737015509 phosphorylation site [posttranslational modification] 1217737015510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1217737015511 ATP binding site [chemical binding]; other site 1217737015512 Mg2+ binding site [ion binding]; other site 1217737015513 G-X-G motif; other site 1217737015514 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1217737015515 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1217737015516 Substrate-binding site [chemical binding]; other site 1217737015517 Substrate specificity [chemical binding]; other site 1217737015518 biotin synthase; Provisional; Region: PRK08508 1217737015519 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1217737015520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1217737015521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737015522 Zn2+ binding site [ion binding]; other site 1217737015523 Mg2+ binding site [ion binding]; other site 1217737015524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1217737015525 DNA binding residues [nucleotide binding] 1217737015526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1217737015527 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 1217737015528 active site 1217737015529 putative DNA-binding cleft [nucleotide binding]; other site 1217737015530 dimer interface [polypeptide binding]; other site 1217737015531 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 1217737015532 BRO family, N-terminal domain; Region: Bro-N; smart01040 1217737015533 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1217737015534 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1217737015535 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1217737015536 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737015537 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1217737015538 active site 1217737015539 metal binding site [ion binding]; metal-binding site 1217737015540 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1217737015541 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1217737015542 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 1217737015543 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1217737015544 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1217737015545 Walker A motif; other site 1217737015546 ATP binding site [chemical binding]; other site 1217737015547 Walker B motif; other site 1217737015548 Yqey-like protein; Region: YqeY; cl17540 1217737015549 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 1217737015550 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1217737015551 active site 1217737015552 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1217737015553 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1217737015554 active site 1217737015555 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1217737015556 GIY-YIG motif/motif A; other site 1217737015557 active site 1217737015558 catalytic site [active] 1217737015559 putative DNA binding site [nucleotide binding]; other site 1217737015560 metal binding site [ion binding]; metal-binding site 1217737015561 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1217737015562 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1217737015563 putative metal binding site [ion binding]; other site 1217737015564 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1217737015565 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1217737015566 putative metal binding site [ion binding]; other site 1217737015567 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1217737015568 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1217737015569 DHH family; Region: DHH; pfam01368 1217737015570 DHHA1 domain; Region: DHHA1; pfam02272 1217737015571 NAD-dependent deacetylase; Provisional; Region: PRK00481 1217737015572 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1217737015573 NAD+ binding site [chemical binding]; other site 1217737015574 substrate binding site [chemical binding]; other site 1217737015575 Zn binding site [ion binding]; other site 1217737015576 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1217737015577 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1217737015578 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1217737015579 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1217737015580 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1217737015581 active site 1217737015582 catalytic residues [active] 1217737015583 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1217737015584 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1217737015585 DNA binding residues [nucleotide binding] 1217737015586 Replication terminator protein; Region: RTP; pfam02334 1217737015587 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1217737015588 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737015589 active site 1217737015590 DNA binding site [nucleotide binding] 1217737015591 Int/Topo IB signature motif; other site 1217737015592 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1217737015593 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1217737015594 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1217737015595 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1217737015596 active site 1217737015597 dimer interface [polypeptide binding]; other site 1217737015598 catalytic residues [active] 1217737015599 effector binding site; other site 1217737015600 R2 peptide binding site; other site 1217737015601 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1217737015602 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1217737015603 dimer interface [polypeptide binding]; other site 1217737015604 putative radical transfer pathway; other site 1217737015605 diiron center [ion binding]; other site 1217737015606 tyrosyl radical; other site 1217737015607 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1217737015608 catalytic residues [active] 1217737015609 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 1217737015610 homodimer interface [polypeptide binding]; other site 1217737015611 metal binding site [ion binding]; metal-binding site 1217737015612 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1217737015613 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1217737015614 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1217737015615 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1217737015616 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1217737015617 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1217737015618 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1217737015619 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 1217737015620 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 1217737015621 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1217737015622 Integrase core domain; Region: rve; pfam00665 1217737015623 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1217737015624 potential frameshift: common BLAST hit: gi|161598601|ref|YP_001573816.1| IS element transposase 1217737015625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1217737015626 putative substrate translocation pore; other site 1217737015627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1217737015628 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1217737015629 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1217737015630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1217737015631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1217737015632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1217737015633 dimerization interface [polypeptide binding]; other site 1217737015634 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1217737015635 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1217737015636 FMN binding site [chemical binding]; other site 1217737015637 substrate binding site [chemical binding]; other site 1217737015638 putative catalytic residue [active] 1217737015639 Mad3/BUB1 homology region 1; Region: Mad3_BUB1_I; cl07066 1217737015640 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015641 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015643 Integrase core domain; Region: rve; pfam00665 1217737015644 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1217737015645 Transposase domain (DUF772); Region: DUF772; pfam05598 1217737015646 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1217737015647 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1217737015648 Spore germination protein; Region: Spore_permease; cl17796 1217737015649 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1217737015650 potential frameshift: common BLAST hit: gi|163940306|ref|YP_001645190.1| phosphatidylinositol-specific phospholipase C X region 1217737015651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015652 Integrase core domain; Region: rve; pfam00665 1217737015653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737015654 dimerization interface [polypeptide binding]; other site 1217737015655 putative DNA binding site [nucleotide binding]; other site 1217737015656 putative Zn2+ binding site [ion binding]; other site 1217737015657 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1217737015658 IHF dimer interface [polypeptide binding]; other site 1217737015659 IHF - DNA interface [nucleotide binding]; other site 1217737015660 bacterial Hfq-like; Region: Hfq; cd01716 1217737015661 hexamer interface [polypeptide binding]; other site 1217737015662 Sm1 motif; other site 1217737015663 RNA binding site [nucleotide binding]; other site 1217737015664 Sm2 motif; other site 1217737015665 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1217737015666 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1217737015667 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1217737015668 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1217737015669 EamA-like transporter family; Region: EamA; pfam00892 1217737015670 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1217737015671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737015672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737015673 homodimer interface [polypeptide binding]; other site 1217737015674 catalytic residue [active] 1217737015675 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1217737015676 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1217737015677 dimer interface [polypeptide binding]; other site 1217737015678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737015679 catalytic residue [active] 1217737015680 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1217737015681 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1217737015682 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1217737015683 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1217737015684 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1217737015685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1217737015686 DNA-binding site [nucleotide binding]; DNA binding site 1217737015687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1217737015688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1217737015689 homodimer interface [polypeptide binding]; other site 1217737015690 catalytic residue [active] 1217737015691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015692 Integrase core domain; Region: rve; pfam00665 1217737015693 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1217737015694 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1217737015695 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737015696 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1217737015697 catalytic residues [active] 1217737015698 catalytic nucleophile [active] 1217737015699 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737015700 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737015701 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737015702 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737015703 DNA binding site [nucleotide binding] 1217737015704 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1217737015705 DNA-binding interface [nucleotide binding]; DNA binding site 1217737015706 Putative zinc-finger; Region: zf-HC2; pfam13490 1217737015707 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1217737015708 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1217737015709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1217737015710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1217737015711 DNA binding residues [nucleotide binding] 1217737015712 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1217737015713 delta endotoxin; Region: Endotoxin_M; pfam00555 1217737015714 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1217737015715 putative metal binding site [ion binding]; other site 1217737015716 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 1217737015717 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1217737015718 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1217737015719 active site 1217737015720 metal binding site [ion binding]; metal-binding site 1217737015721 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 1217737015722 SEC-C motif; Region: SEC-C; pfam02810 1217737015723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015725 Bacillus thuringiensis P21 molecular chaperone protein; Region: Bt_P21; pfam05560 1217737015726 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1217737015727 CryBP1 protein; Region: CryBP1; pfam07029 1217737015728 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 1217737015729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737015730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015731 non-specific DNA binding site [nucleotide binding]; other site 1217737015732 salt bridge; other site 1217737015733 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015734 Replication-relaxation; Region: Replic_Relax; pfam13814 1217737015735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1217737015736 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1217737015737 Integrase core domain; Region: rve; pfam00665 1217737015738 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1217737015739 Integrase core domain; Region: rve; pfam00665 1217737015740 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1217737015741 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 1217737015742 DNA binding residues [nucleotide binding] 1217737015743 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1217737015744 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1217737015745 nucleotide binding site [chemical binding]; other site 1217737015746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015747 Integrase core domain; Region: rve; pfam00665 1217737015748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1217737015749 active site 1217737015750 metal binding site [ion binding]; metal-binding site 1217737015751 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1217737015752 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1217737015753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015754 Integrase core domain; Region: rve; pfam00665 1217737015755 DNA topoisomerase I; Validated; Region: PRK06599 1217737015756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1217737015757 dimerization interface [polypeptide binding]; other site 1217737015758 putative DNA binding site [nucleotide binding]; other site 1217737015759 putative Zn2+ binding site [ion binding]; other site 1217737015760 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1217737015761 Sm and related proteins; Region: Sm_like; cl00259 1217737015762 heptamer interface [polypeptide binding]; other site 1217737015763 Sm1 motif; other site 1217737015764 hexamer interface [polypeptide binding]; other site 1217737015765 RNA binding site [nucleotide binding]; other site 1217737015766 Sm2 motif; other site 1217737015767 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1217737015768 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737015769 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737015770 catalytic residues [active] 1217737015771 catalytic nucleophile [active] 1217737015772 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737015773 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737015774 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737015775 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737015776 DNA binding site [nucleotide binding] 1217737015777 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1217737015778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737015779 Walker A/P-loop; other site 1217737015780 ATP binding site [chemical binding]; other site 1217737015781 Q-loop/lid; other site 1217737015782 ABC transporter signature motif; other site 1217737015783 Walker B; other site 1217737015784 D-loop; other site 1217737015785 H-loop/switch region; other site 1217737015786 Integral membrane protein DUF95; Region: DUF95; pfam01944 1217737015787 circular bacteriocin, circularin A/uberolysin family; Region: circ_ocin_uber; TIGR03651 1217737015788 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1217737015789 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1217737015790 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1217737015791 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1217737015792 Walker A/P-loop; other site 1217737015793 ATP binding site [chemical binding]; other site 1217737015794 Q-loop/lid; other site 1217737015795 ABC transporter signature motif; other site 1217737015796 Walker B; other site 1217737015797 D-loop; other site 1217737015798 H-loop/switch region; other site 1217737015799 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1217737015800 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1217737015801 FtsX-like permease family; Region: FtsX; pfam02687 1217737015802 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1217737015803 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1217737015804 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1217737015805 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015806 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015807 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 1217737015808 SEC-C motif; Region: SEC-C; pfam02810 1217737015809 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1217737015810 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1217737015811 Integrase core domain; Region: rve; pfam00665 1217737015812 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1217737015813 delta endotoxin; Region: Endotoxin_M; pfam00555 1217737015814 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1217737015815 putative metal binding site [ion binding]; other site 1217737015816 potential frameshift: common BLAST hit: gi|384183380|ref|YP_005569141.1| IS element transposase 1217737015817 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1217737015818 delta endotoxin; Region: Endotoxin_M; pfam00555 1217737015819 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1217737015820 putative metal binding site [ion binding]; other site 1217737015821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015823 Integrase core domain; Region: rve; pfam00665 1217737015824 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 1217737015825 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1217737015826 putative sugar binding sites [chemical binding]; other site 1217737015827 Q-X-W motif; other site 1217737015828 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1217737015829 putative sugar binding sites [chemical binding]; other site 1217737015830 Q-X-W motif; other site 1217737015831 potential frameshift: common BLAST hit: gi|163940300|ref|YP_001645184.1| GerA spore germination protein 1217737015832 Spore germination protein; Region: Spore_permease; cl17796 1217737015833 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1217737015834 Integrase core domain; Region: rve; pfam00665 1217737015835 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1217737015836 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1217737015837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1217737015838 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015839 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015840 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737015841 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737015842 catalytic residues [active] 1217737015843 catalytic nucleophile [active] 1217737015844 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737015845 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737015846 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737015847 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737015848 DNA binding site [nucleotide binding] 1217737015849 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1217737015850 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1217737015851 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1217737015852 RHS Repeat; Region: RHS_repeat; pfam05593 1217737015853 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1217737015854 RHS Repeat; Region: RHS_repeat; cl11982 1217737015855 RHS Repeat; Region: RHS_repeat; pfam05593 1217737015856 RHS protein; Region: RHS; pfam03527 1217737015857 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1217737015858 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1217737015859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015860 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1217737015861 FkbH-like domain; Region: FkbH; TIGR01686 1217737015862 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1217737015863 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1217737015864 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737015865 catalytic residues [active] 1217737015866 catalytic nucleophile [active] 1217737015867 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737015868 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737015869 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737015870 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737015871 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1217737015872 DNA-binding interface [nucleotide binding]; DNA binding site 1217737015873 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1217737015874 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1217737015875 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1217737015876 Predicted transcriptional regulators [Transcription]; Region: COG1695 1217737015877 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1217737015878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1217737015879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1217737015880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737015881 Walker A/P-loop; other site 1217737015882 ATP binding site [chemical binding]; other site 1217737015883 Q-loop/lid; other site 1217737015884 ABC transporter signature motif; other site 1217737015885 Walker B; other site 1217737015886 D-loop; other site 1217737015887 H-loop/switch region; other site 1217737015888 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1217737015889 active site 1217737015890 ATP binding site [chemical binding]; other site 1217737015891 substrate binding site [chemical binding]; other site 1217737015892 activation loop (A-loop); other site 1217737015893 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1217737015894 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 1217737015895 active site 1217737015896 zinc binding site [ion binding]; other site 1217737015897 Initiator Replication protein; Region: Rep_3; pfam01051 1217737015898 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1217737015899 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1217737015900 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1217737015901 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1217737015902 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 1217737015903 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1217737015904 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737015905 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737015906 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1217737015907 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1217737015908 AAA-like domain; Region: AAA_10; pfam12846 1217737015909 Walker A motif; other site 1217737015910 ATP binding site [chemical binding]; other site 1217737015911 TcpE family; Region: TcpE; pfam12648 1217737015912 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1217737015913 Replication-relaxation; Region: Replic_Relax; pfam13814 1217737015914 AAA-like domain; Region: AAA_10; pfam12846 1217737015915 TQXA domain; Region: TQXA_dom; TIGR03934 1217737015916 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737015917 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737015918 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737015919 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737015920 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737015921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015922 non-specific DNA binding site [nucleotide binding]; other site 1217737015923 salt bridge; other site 1217737015924 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737015926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015927 non-specific DNA binding site [nucleotide binding]; other site 1217737015928 salt bridge; other site 1217737015929 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015930 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1217737015931 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1217737015932 active site 1217737015933 catalytic residues [active] 1217737015934 DNA binding site [nucleotide binding] 1217737015935 Int/Topo IB signature motif; other site 1217737015936 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737015937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015938 non-specific DNA binding site [nucleotide binding]; other site 1217737015939 salt bridge; other site 1217737015940 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1217737015942 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1217737015943 Peptidase family M23; Region: Peptidase_M23; pfam01551 1217737015944 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1217737015945 putative protofilament interface [polypeptide binding]; other site 1217737015946 nucleotide binding site [chemical binding]; other site 1217737015947 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1217737015948 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1217737015949 putative active site [active] 1217737015950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015951 non-specific DNA binding site [nucleotide binding]; other site 1217737015952 salt bridge; other site 1217737015953 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015954 Replication-relaxation; Region: Replic_Relax; pfam13814 1217737015955 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737015956 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1217737015957 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1217737015958 Fic family protein [Function unknown]; Region: COG3177 1217737015959 Fic/DOC family; Region: Fic; pfam02661 1217737015960 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1217737015961 active site 1217737015962 catalytic site [active] 1217737015963 putative metal binding site [ion binding]; other site 1217737015964 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1217737015965 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1217737015966 catalytic residues [active] 1217737015967 catalytic nucleophile [active] 1217737015968 Presynaptic Site I dimer interface [polypeptide binding]; other site 1217737015969 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1217737015970 Synaptic Flat tetramer interface [polypeptide binding]; other site 1217737015971 Synaptic Site I dimer interface [polypeptide binding]; other site 1217737015972 DNA binding site [nucleotide binding] 1217737015973 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1217737015974 DNA binding site [nucleotide binding] 1217737015975 active site 1217737015976 Int/Topo IB signature motif; other site 1217737015977 catalytic residues [active] 1217737015978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015979 non-specific DNA binding site [nucleotide binding]; other site 1217737015980 salt bridge; other site 1217737015981 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015982 MarR family; Region: MarR_2; pfam12802 1217737015983 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1217737015984 MarR family; Region: MarR_2; cl17246 1217737015985 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1217737015986 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1217737015987 glycine dehydrogenase (decarboxylating); Region: PLN02414 1217737015988 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1217737015989 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1217737015990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737015991 non-specific DNA binding site [nucleotide binding]; other site 1217737015992 salt bridge; other site 1217737015993 sequence-specific DNA binding site [nucleotide binding]; other site 1217737015994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1217737015995 ABC transporter signature motif; other site 1217737015996 Walker B; other site 1217737015997 D-loop; other site 1217737015998 H-loop/switch region; other site 1217737015999 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1217737016000 active site 1217737016001 metal binding site [ion binding]; metal-binding site 1217737016002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1217737016003 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1217737016004 Pectinesterase/pectinesterase inhibitor; Region: PLN02313 1217737016005 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1217737016006 active site 1217737016007 metal binding site [ion binding]; metal-binding site 1217737016008 interdomain interaction site; other site 1217737016009 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1217737016010 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1217737016011 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1217737016012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1217737016013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1217737016014 active site 1217737016015 ATP binding site [chemical binding]; other site 1217737016016 substrate binding site [chemical binding]; other site 1217737016017 activation loop (A-loop); other site 1217737016018 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1217737016019 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1217737016020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1217737016021 Zn2+ binding site [ion binding]; other site 1217737016022 Mg2+ binding site [ion binding]; other site 1217737016023 Protein phosphatase 2C; Region: PP2C; pfam00481 1217737016024 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1217737016025 active site 1217737016026 pyruvate oxidase; Provisional; Region: PRK08611 1217737016027 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1217737016028 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1217737016029 phosphopeptide binding site; other site 1217737016030 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1217737016031 SprT homologues; Region: SprT; cl01182 1217737016032 Predicted secreted protein [Function unknown]; Region: COG4086 1217737016033 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1217737016034 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1217737016035 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1217737016036 active site 1217737016037 catalytic site [active] 1217737016038 substrate binding site [chemical binding]; other site 1217737016039 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1217737016040 active site 1217737016041 DNA binding site [nucleotide binding] 1217737016042 catalytic site [active] 1217737016043 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1217737016044 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1217737016045 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1217737016046 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1217737016047 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1217737016048 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1217737016049 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737016050 amidase catalytic site [active] 1217737016051 Zn binding residues [ion binding]; other site 1217737016052 substrate binding site [chemical binding]; other site 1217737016053 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737016054 S-layer homology domain; Region: SLH; pfam00395 1217737016055 S-layer homology domain; Region: SLH; pfam00395 1217737016056 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1217737016057 amidase catalytic site [active] 1217737016058 Zn binding residues [ion binding]; other site 1217737016059 substrate binding site [chemical binding]; other site 1217737016060 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737016061 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737016062 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737016063 Bacterial SH3 domain; Region: SH3_3; pfam08239 1217737016064 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1217737016065 metal binding triad [ion binding]; metal-binding site 1217737016066 Fic/DOC family; Region: Fic; cl00960 1217737016067 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1217737016068 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1217737016069 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1217737016070 Alpha-helical domain 2; Region: alpha-hel2; pfam14456 1217737016071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737016072 non-specific DNA binding site [nucleotide binding]; other site 1217737016073 salt bridge; other site 1217737016074 sequence-specific DNA binding site [nucleotide binding]; other site 1217737016075 Short C-terminal domain; Region: SHOCT; pfam09851 1217737016076 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1217737016077 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1217737016078 active site 1217737016079 dUTPase; Region: dUTPase_2; pfam08761 1217737016080 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1217737016081 active site 1217737016082 homodimer interface [polypeptide binding]; other site 1217737016083 metal binding site [ion binding]; metal-binding site 1217737016084 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1217737016085 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1217737016086 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1217737016087 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1217737016088 nucleotide binding pocket [chemical binding]; other site 1217737016089 K-X-D-G motif; other site 1217737016090 catalytic site [active] 1217737016091 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1217737016092 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1217737016093 DNA-binding interface [nucleotide binding]; DNA binding site 1217737016094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1217737016095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737016096 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1217737016097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1217737016098 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1217737016099 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1217737016100 CHC2 zinc finger; Region: zf-CHC2; cl17510 1217737016101 Polysaccharide biosynthesis; Region: Polysacc_synt_4; cl04661 1217737016102 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1217737016103 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1217737016104 Walker B motif; other site 1217737016105 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1217737016106 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 1217737016107 CAP-like domain; other site 1217737016108 active site 1217737016109 primary dimer interface [polypeptide binding]; other site 1217737016110 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1217737016111 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1217737016112 active site 1217737016113 putative metal-binding site [ion binding]; other site 1217737016114 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1217737016115 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1217737016116 metal binding site [ion binding]; metal-binding site 1217737016117 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 1217737016118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737016119 sequence-specific DNA binding site [nucleotide binding]; other site 1217737016120 salt bridge; other site 1217737016121 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1217737016122 aspartate-rich region 2; other site 1217737016123 substrate-Mg2+ binding site; other site 1217737016124 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1217737016125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1217737016126 ATP binding site [chemical binding]; other site 1217737016127 putative Mg++ binding site [ion binding]; other site 1217737016128 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1217737016129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1217737016130 nucleotide binding region [chemical binding]; other site 1217737016131 ATP-binding site [chemical binding]; other site 1217737016132 SpoVG; Region: SpoVG; cl00915 1217737016133 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1217737016134 AAA-like domain; Region: AAA_10; pfam12846 1217737016135 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1217737016136 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1217737016137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1217737016138 non-specific DNA binding site [nucleotide binding]; other site 1217737016139 salt bridge; other site 1217737016140 sequence-specific DNA binding site [nucleotide binding]; other site 1217737016141 hypothetical protein; Provisional; Region: PRK08445 1217737016142 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1217737016143 putative active site [active] 1217737016144 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1217737016145 Domain of unknown function (DUF955); Region: DUF955; cl01076 1217737016146 Late expression factor 8 (LEF-8); Region: LEF-8; pfam04941 1217737016147 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1217737016148 GIY-YIG motif/motif A; other site 1217737016149 putative active site [active] 1217737016150 putative metal binding site [ion binding]; other site 1217737016151 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1217737016152 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016153 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016154 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016155 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016156 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016157 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016158 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016159 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016160 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016161 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016162 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016163 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016164 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016165 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016166 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016167 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016168 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016169 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1217737016170 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1217737016171 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1217737016172 active site 1217737016173 catalytic site [active] 1217737016174 SH3-like domain; Region: SH3_8; pfam13457 1217737016175 SH3-like domain; Region: SH3_8; pfam13457 1217737016176 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1217737016177 putative active site [active] 1217737016178 TQXA domain; Region: TQXA_dom; TIGR03934 1217737016179 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016180 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016181 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016182 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016183 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016184 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016185 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016186 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016187 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016188 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016189 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016190 Cna protein B-type domain; Region: Cna_B; pfam05738 1217737016191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1217737016192 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1217737016193 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1217737016194 putative active site [active] 1217737016195 Catalase-related immune-responsive; Region: Catalase-rel; pfam06628 1217737016196 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1217737016197 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1217737016198 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1217737016199 Mg binding site [ion binding]; other site 1217737016200 nucleotide binding site [chemical binding]; other site 1217737016201 putative protofilament interface [polypeptide binding]; other site 1217737016202 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1217737016203 DHH family; Region: DHH; pfam01368 1217737016204 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1217737016205 RNA/DNA hybrid binding site [nucleotide binding]; other site 1217737016206 active site 1217737016207 Predicted transcriptional regulators [Transcription]; Region: COG1378 1217737016208 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1217737016209 Family description; Region: UvrD_C_2; pfam13538 1217737016210 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1217737016211 G4 box; other site 1217737016212 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1217737016213 HSP70 interaction site [polypeptide binding]; other site 1217737016214 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1217737016215 active site 1217737016216 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1217737016217 Peptidase M15; Region: Peptidase_M15_3; cl01194 1217737016218 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1217737016219 AAA-like domain; Region: AAA_10; pfam12846 1217737016220 AAA-like domain; Region: AAA_10; pfam12846 1217737016221 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1217737016222 DNA polymerase; Provisional; Region: PHA02563 1217737016223 hypothetical protein; Region: PHA01548 1217737016224 Helix-turn-helix domain; Region: HTH_17; cl17695