-- dump date   	20140618_235258
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1195464000001	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1195464000002	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464000003	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000004	non-specific DNA binding site [nucleotide binding]; other site
1195464000005	salt bridge; other site
1195464000006	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000007	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000008	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000009	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000010	putative metal binding site [ion binding]; other site
1195464000011	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000012	Integrase core domain; Region: rve; pfam00665
1195464000013	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1195464000014	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464000015	DNA binding residues [nucleotide binding]
1195464000016	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1195464000017	Mg binding site [ion binding]; other site
1195464000018	nucleotide binding site [chemical binding]; other site
1195464000019	putative protofilament interface [polypeptide binding]; other site
1195464000020	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464000021	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1195464000022	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1195464000023	active site
1195464000024	catalytic residues [active]
1195464000025	DNA binding site [nucleotide binding]
1195464000026	Int/Topo IB signature motif; other site
1195464000027	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464000028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000029	non-specific DNA binding site [nucleotide binding]; other site
1195464000030	salt bridge; other site
1195464000031	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000032	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1195464000033	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000034	non-specific DNA binding site [nucleotide binding]; other site
1195464000035	salt bridge; other site
1195464000036	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000037	TQXA domain; Region: TQXA_dom; TIGR03934
1195464000038	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000039	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000040	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000041	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000042	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000043	AAA-like domain; Region: AAA_10; pfam12846
1195464000044	Replication-relaxation; Region: Replic_Relax; pfam13814
1195464000045	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1195464000046	TcpE family; Region: TcpE; pfam12648
1195464000047	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000048	AAA-like domain; Region: AAA_10; pfam12846
1195464000049	Walker A motif; other site
1195464000050	ATP binding site [chemical binding]; other site
1195464000051	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1195464000052	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1195464000053	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464000054	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464000055	conjugal transfer protein TrbE; Provisional; Region: PRK13830
1195464000056	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1195464000057	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1195464000058	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1195464000059	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1195464000060	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464000061	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464000062	bacterial Hfq-like; Region: Hfq; cd01716
1195464000063	hexamer interface [polypeptide binding]; other site
1195464000064	Sm1 motif; other site
1195464000065	RNA binding site [nucleotide binding]; other site
1195464000066	Sm2 motif; other site
1195464000067	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1195464000068	IHF dimer interface [polypeptide binding]; other site
1195464000069	IHF - DNA interface [nucleotide binding]; other site
1195464000070	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464000071	dimerization interface [polypeptide binding]; other site
1195464000072	putative DNA binding site [nucleotide binding]; other site
1195464000073	putative Zn2+ binding site [ion binding]; other site
1195464000074	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1195464000075	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1195464000076	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1195464000077	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000078	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464000079	catalytic residues [active]
1195464000080	catalytic nucleophile [active]
1195464000081	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464000082	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464000083	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464000084	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464000085	DNA binding site [nucleotide binding]
1195464000086	Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415
1195464000087	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000088	active site
1195464000089	catalytic site [active]
1195464000090	putative metal binding site [ion binding]; other site
1195464000091	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000092	putative sugar binding sites [chemical binding]; other site
1195464000093	Ricin-type beta-trefoil; Region: RICIN; smart00458
1195464000094	Q-X-W motif; other site
1195464000095	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000096	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464000097	catalytic residues [active]
1195464000098	catalytic nucleophile [active]
1195464000099	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464000100	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464000101	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464000102	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464000103	DNA binding site [nucleotide binding]
1195464000104	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000105	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000106	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000107	putative metal binding site [ion binding]; other site
1195464000108	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000109	active site
1195464000110	catalytic site [active]
1195464000111	putative metal binding site [ion binding]; other site
1195464000112	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000113	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000114	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000115	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000117	Integrase core domain; Region: rve; pfam00665
1195464000118	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000119	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1195464000120	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1195464000121	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1195464000122	Helix-turn-helix domain; Region: HTH_28; pfam13518
1195464000123	putative transposase OrfB; Reviewed; Region: PHA02517
1195464000124	HTH-like domain; Region: HTH_21; pfam13276
1195464000125	Integrase core domain; Region: rve; pfam00665
1195464000126	Integrase core domain; Region: rve_3; pfam13683
1195464000127	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000128	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000129	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
1195464000130	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1195464000131	HlyD family secretion protein; Region: HlyD_3; pfam13437
1195464000132	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1195464000133	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1195464000134	putative active site [active]
1195464000135	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464000136	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464000137	Walker A/P-loop; other site
1195464000138	ATP binding site [chemical binding]; other site
1195464000139	Q-loop/lid; other site
1195464000140	ABC transporter signature motif; other site
1195464000141	Walker B; other site
1195464000142	D-loop; other site
1195464000143	H-loop/switch region; other site
1195464000144	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1195464000145	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464000146	active site
1195464000147	DNA binding site [nucleotide binding]
1195464000148	Int/Topo IB signature motif; other site
1195464000149	YueH-like protein; Region: YueH; pfam14166
1195464000150	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1195464000151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000152	Integrase core domain; Region: rve; pfam00665
1195464000153	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000154	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1195464000155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000156	Walker A motif; other site
1195464000157	ATP binding site [chemical binding]; other site
1195464000158	Walker B motif; other site
1195464000159	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1195464000160	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000161	Walker A motif; other site
1195464000162	ATP binding site [chemical binding]; other site
1195464000163	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1195464000164	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1195464000165	K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927
1195464000166	AAA-like domain; Region: AAA_10; pfam12846
1195464000167	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1195464000168	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1195464000169	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1195464000170	putative active site [active]
1195464000171	putative NTP binding site [chemical binding]; other site
1195464000172	putative nucleic acid binding site [nucleotide binding]; other site
1195464000173	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464000174	active site
1195464000175	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1195464000176	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464000177	NlpC/P60 family; Region: NLPC_P60; cl17555
1195464000178	Domain of unknown function (DUF955); Region: DUF955; cl01076
1195464000179	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1195464000180	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1195464000181	Toprim-like; Region: Toprim_2; pfam13155
1195464000182	Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958
1195464000183	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1195464000184	DNA topoisomerase III; Provisional; Region: PRK07726
1195464000185	active site
1195464000186	putative interdomain interaction site [polypeptide binding]; other site
1195464000187	putative metal-binding site [ion binding]; other site
1195464000188	putative nucleotide binding site [chemical binding]; other site
1195464000189	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464000190	domain I; other site
1195464000191	DNA binding groove [nucleotide binding]
1195464000192	phosphate binding site [ion binding]; other site
1195464000193	domain II; other site
1195464000194	domain III; other site
1195464000195	nucleotide binding site [chemical binding]; other site
1195464000196	catalytic site [active]
1195464000197	domain IV; other site
1195464000198	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464000199	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464000200	CAAX protease self-immunity; Region: Abi; pfam02517
1195464000201	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000202	non-specific DNA binding site [nucleotide binding]; other site
1195464000203	salt bridge; other site
1195464000204	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000205	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1195464000206	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1195464000207	active site
1195464000208	catalytic residues [active]
1195464000209	DNA binding site [nucleotide binding]
1195464000210	Int/Topo IB signature motif; other site
1195464000211	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000212	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464000213	catalytic residues [active]
1195464000214	catalytic nucleophile [active]
1195464000215	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464000216	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464000217	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464000218	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464000219	DNA binding site [nucleotide binding]
1195464000220	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1195464000221	DNA protecting protein DprA; Region: dprA; TIGR00732
1195464000222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464000223	Walker B; other site
1195464000224	H-loop/switch region; other site
1195464000225	CAAX protease self-immunity; Region: Abi; pfam02517
1195464000226	YolD-like protein; Region: YolD; pfam08863
1195464000227	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1195464000228	DNA polymerase IV; Reviewed; Region: PRK03103
1195464000229	active site
1195464000230	DNA binding site [nucleotide binding]
1195464000231	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1195464000232	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464000233	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464000234	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464000235	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464000236	peptide binding site [polypeptide binding]; other site
1195464000237	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464000238	dimerization interface [polypeptide binding]; other site
1195464000239	putative DNA binding site [nucleotide binding]; other site
1195464000240	putative Zn2+ binding site [ion binding]; other site
1195464000241	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1195464000242	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464000243	P-loop; other site
1195464000244	Magnesium ion binding site [ion binding]; other site
1195464000245	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464000246	Magnesium ion binding site [ion binding]; other site
1195464000247	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1195464000248	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1195464000249	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000250	Walker A motif; other site
1195464000251	ATP binding site [chemical binding]; other site
1195464000252	Walker B motif; other site
1195464000253	TrbC/VIRB2 family; Region: TrbC; pfam04956
1195464000254	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
1195464000255	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000256	Walker A motif; other site
1195464000257	ATP binding site [chemical binding]; other site
1195464000258	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1195464000259	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1195464000260	AAA-like domain; Region: AAA_10; pfam12846
1195464000261	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1195464000262	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1195464000263	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1195464000264	putative active site [active]
1195464000265	putative NTP binding site [chemical binding]; other site
1195464000266	putative nucleic acid binding site [nucleotide binding]; other site
1195464000267	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464000268	active site
1195464000269	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1195464000270	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464000271	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464000272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000273	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000274	salt bridge; other site
1195464000275	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
1195464000276	ADP-ribose binding site [chemical binding]; other site
1195464000277	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1195464000278	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1195464000279	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1195464000280	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1195464000281	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1195464000282	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464000283	nucleotide binding region [chemical binding]; other site
1195464000284	ATP-binding site [chemical binding]; other site
1195464000285	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1195464000286	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1195464000287	Toprim-like; Region: Toprim_2; pfam13155
1195464000288	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1195464000289	DNA topoisomerase III; Provisional; Region: PRK07726
1195464000290	active site
1195464000291	putative interdomain interaction site [polypeptide binding]; other site
1195464000292	putative metal-binding site [ion binding]; other site
1195464000293	putative nucleotide binding site [chemical binding]; other site
1195464000294	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464000295	domain I; other site
1195464000296	DNA binding groove [nucleotide binding]
1195464000297	phosphate binding site [ion binding]; other site
1195464000298	domain II; other site
1195464000299	domain III; other site
1195464000300	nucleotide binding site [chemical binding]; other site
1195464000301	catalytic site [active]
1195464000302	domain IV; other site
1195464000303	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464000304	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464000305	CAAX protease self-immunity; Region: Abi; pfam02517
1195464000306	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1195464000307	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1195464000308	active site
1195464000309	catalytic residues [active]
1195464000310	DNA binding site [nucleotide binding]
1195464000311	Int/Topo IB signature motif; other site
1195464000312	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000313	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464000314	catalytic residues [active]
1195464000315	catalytic nucleophile [active]
1195464000316	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464000317	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464000318	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464000319	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464000320	DNA binding site [nucleotide binding]
1195464000321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464000322	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
1195464000323	YolD-like protein; Region: YolD; pfam08863
1195464000324	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464000325	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464000326	DNA binding residues [nucleotide binding]
1195464000327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000328	Integrase core domain; Region: rve; pfam00665
1195464000329	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000330	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000331	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000332	putative metal binding site [ion binding]; other site
1195464000333	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
1195464000334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000335	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1195464000336	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464000337	catalytic residues [active]
1195464000338	catalytic nucleophile [active]
1195464000339	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464000340	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464000341	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464000342	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464000343	DNA binding site [nucleotide binding]
1195464000344	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
1195464000345	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1195464000346	active site
1195464000347	metal binding site [ion binding]; metal-binding site
1195464000348	Ricin-type beta-trefoil; Region: RICIN; smart00458
1195464000349	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
1195464000350	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000351	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000352	YolD-like protein; Region: YolD; pfam08863
1195464000353	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464000354	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464000355	DNA binding residues [nucleotide binding]
1195464000356	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464000357	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464000358	peptide binding site [polypeptide binding]; other site
1195464000359	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
1195464000360	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000361	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000362	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464000363	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1195464000364	P-loop; other site
1195464000365	Magnesium ion binding site [ion binding]; other site
1195464000366	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464000367	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1195464000368	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
1195464000369	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1195464000370	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000371	Walker A motif; other site
1195464000372	ATP binding site [chemical binding]; other site
1195464000373	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1195464000374	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1195464000375	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1195464000376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1195464000377	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1195464000378	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1195464000379	TQXA domain; Region: TQXA_dom; TIGR03934
1195464000380	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000381	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000382	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000383	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464000384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000385	salt bridge; other site
1195464000386	non-specific DNA binding site [nucleotide binding]; other site
1195464000387	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000389	non-specific DNA binding site [nucleotide binding]; other site
1195464000390	salt bridge; other site
1195464000391	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000392	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464000393	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464000394	DNA binding residues [nucleotide binding]
1195464000395	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1195464000396	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1195464000397	Mg binding site [ion binding]; other site
1195464000398	nucleotide binding site [chemical binding]; other site
1195464000399	putative protofilament interface [polypeptide binding]; other site
1195464000400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464000401	TPR motif; other site
1195464000402	binding surface
1195464000403	Initiator Replication protein; Region: Rep_3; pfam01051
1195464000404	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000405	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000406	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000407	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000408	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000409	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000410	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000411	putative metal binding site [ion binding]; other site
1195464000412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000413	Integrase core domain; Region: rve; pfam00665
1195464000414	Replication-relaxation; Region: Replic_Relax; pfam13814
1195464000415	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464000416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000417	non-specific DNA binding site [nucleotide binding]; other site
1195464000418	salt bridge; other site
1195464000419	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000421	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1195464000422	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1195464000423	Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338
1195464000424	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000425	putative sugar binding sites [chemical binding]; other site
1195464000426	Q-X-W motif; other site
1195464000427	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000428	putative sugar binding sites [chemical binding]; other site
1195464000429	Q-X-W motif; other site
1195464000430	Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338
1195464000431	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1195464000432	putative ADP-binding pocket [chemical binding]; other site
1195464000433	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1195464000434	active site
1195464000435	ATP binding site [chemical binding]; other site
1195464000436	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1195464000437	active site
1195464000438	substrate binding site [chemical binding]; other site
1195464000439	ATP binding site [chemical binding]; other site
1195464000440	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464000441	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1195464000442	putative NAD(P) binding site [chemical binding]; other site
1195464000443	active site
1195464000444	putative substrate binding site [chemical binding]; other site
1195464000445	CryBP1 protein; Region: CryBP1; pfam07029
1195464000446	Transmembrane protein; Region: Macoilin; pfam09726
1195464000447	Transmembrane protein; Region: Macoilin; pfam09726
1195464000448	Transmembrane protein; Region: Macoilin; pfam09726
1195464000449	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000450	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000451	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000452	putative metal binding site [ion binding]; other site
1195464000453	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000454	active site
1195464000455	catalytic site [active]
1195464000456	putative metal binding site [ion binding]; other site
1195464000457	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000458	putative sugar binding sites [chemical binding]; other site
1195464000459	Q-X-W motif; other site
1195464000460	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
1195464000461	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1195464000462	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1195464000463	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1195464000464	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1195464000465	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1195464000466	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1195464000467	active site
1195464000468	tetramer interface; other site
1195464000469	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000470	active site
1195464000471	catalytic site [active]
1195464000472	putative metal binding site [ion binding]; other site
1195464000473	Ricin-type beta-trefoil; Region: RICIN; smart00458
1195464000474	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1195464000475	catalytic nucleophile [active]
1195464000476	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000477	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000478	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000479	putative metal binding site [ion binding]; other site
1195464000480	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1195464000481	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1195464000482	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1195464000483	active site
1195464000484	Int/Topo IB signature motif; other site
1195464000485	catalytic residues [active]
1195464000486	DNA binding site [nucleotide binding]
1195464000487	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000488	active site
1195464000489	catalytic site [active]
1195464000490	putative metal binding site [ion binding]; other site
1195464000491	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000492	putative sugar binding sites [chemical binding]; other site
1195464000493	Q-X-W motif; other site
1195464000494	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1195464000495	CAAX protease self-immunity; Region: Abi; pfam02517
1195464000496	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000497	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000498	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
1195464000499	putative metal binding site [ion binding]; other site
1195464000500	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
1195464000501	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000502	Fic/DOC family; Region: Fic; pfam02661
1195464000503	Fic family protein [Function unknown]; Region: COG3177
1195464000504	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464000505	Spore germination protein; Region: Spore_permease; cl17796
1195464000506	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1195464000507	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000508	delta endotoxin; Region: Endotoxin_M; pfam00555
1195464000509	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1195464000510	metal binding site [ion binding]; metal-binding site
1195464000511	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1195464000512	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000513	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1195464000514	DNA-binding interface [nucleotide binding]; DNA binding site
1195464000515	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1195464000516	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1195464000517	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1195464000518	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464000519	P-loop; other site
1195464000520	Magnesium ion binding site [ion binding]; other site
1195464000521	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464000522	Magnesium ion binding site [ion binding]; other site
1195464000523	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1195464000524	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1195464000525	putative active site [active]
1195464000526	putative NTP binding site [chemical binding]; other site
1195464000527	putative nucleic acid binding site [nucleotide binding]; other site
1195464000528	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464000529	active site
1195464000530	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1195464000531	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000532	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000533	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000534	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000535	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1195464000536	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000537	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000538	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464000539	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
1195464000540	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000541	bacterial Hfq-like; Region: Hfq; cd01716
1195464000542	Sm1 motif; other site
1195464000543	RNA binding site [nucleotide binding]; other site
1195464000544	hexamer interface [polypeptide binding]; other site
1195464000545	Sm2 motif; other site
1195464000546	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464000547	EamA-like transporter family; Region: EamA; cl17759
1195464000548	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1195464000549	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464000550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464000551	homodimer interface [polypeptide binding]; other site
1195464000552	catalytic residue [active]
1195464000553	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1195464000554	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1195464000555	dimer interface [polypeptide binding]; other site
1195464000556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464000557	catalytic residue [active]
1195464000558	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
1195464000559	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1195464000560	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464000561	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464000562	DNA-binding site [nucleotide binding]; DNA binding site
1195464000563	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464000564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464000565	homodimer interface [polypeptide binding]; other site
1195464000566	catalytic residue [active]
1195464000567	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1195464000568	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1195464000569	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1195464000570	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1195464000571	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000572	active site
1195464000573	catalytic site [active]
1195464000574	putative metal binding site [ion binding]; other site
1195464000575	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000576	putative sugar binding sites [chemical binding]; other site
1195464000577	Q-X-W motif; other site
1195464000578	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000580	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1195464000581	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464000582	active site
1195464000583	motif I; other site
1195464000584	motif II; other site
1195464000585	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464000586	dimerization interface [polypeptide binding]; other site
1195464000587	putative DNA binding site [nucleotide binding]; other site
1195464000588	putative Zn2+ binding site [ion binding]; other site
1195464000589	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000590	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464000591	catalytic residues [active]
1195464000592	catalytic nucleophile [active]
1195464000593	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464000594	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464000595	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464000596	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464000597	DNA binding site [nucleotide binding]
1195464000598	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1195464000599	putative catalytic site [active]
1195464000600	metal binding site A [ion binding]; metal-binding site
1195464000601	phosphate binding site [ion binding]; other site
1195464000602	metal binding site C [ion binding]; metal-binding site
1195464000603	metal binding site B [ion binding]; metal-binding site
1195464000604	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000605	active site
1195464000606	catalytic site [active]
1195464000607	putative metal binding site [ion binding]; other site
1195464000608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1195464000609	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1195464000610	Integrase core domain; Region: rve; pfam00665
1195464000611	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464000612	active site
1195464000613	DNA binding site [nucleotide binding]
1195464000614	Int/Topo IB signature motif; other site
1195464000615	Necrosis inducing protein (NPP1); Region: NPP1; pfam05630
1195464000616	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000617	Ricin-type beta-trefoil; Region: RICIN; smart00458
1195464000618	putative sugar binding sites [chemical binding]; other site
1195464000619	Q-X-W motif; other site
1195464000620	Restriction endonuclease; Region: Mrr_cat; pfam04471
1195464000621	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464000622	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1195464000623	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1195464000624	putative active site [active]
1195464000625	putative NTP binding site [chemical binding]; other site
1195464000626	putative nucleic acid binding site [nucleotide binding]; other site
1195464000627	Type II intron maturase; Region: Intron_maturas2; pfam01348
1195464000628	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1195464000629	Toprim-like; Region: Toprim_2; pfam13155
1195464000630	DNA topoisomerase III; Provisional; Region: PRK07726
1195464000631	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1195464000632	active site
1195464000633	putative interdomain interaction site [polypeptide binding]; other site
1195464000634	putative metal-binding site [ion binding]; other site
1195464000635	putative nucleotide binding site [chemical binding]; other site
1195464000636	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464000637	domain I; other site
1195464000638	DNA binding groove [nucleotide binding]
1195464000639	phosphate binding site [ion binding]; other site
1195464000640	domain II; other site
1195464000641	domain III; other site
1195464000642	nucleotide binding site [chemical binding]; other site
1195464000643	catalytic site [active]
1195464000644	domain IV; other site
1195464000645	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464000646	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464000647	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464000648	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464000649	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1195464000650	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1195464000651	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1195464000652	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1195464000653	catalytic residue [active]
1195464000654	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464000655	AAA-like domain; Region: AAA_10; pfam12846
1195464000656	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1195464000657	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1195464000658	putative active site [active]
1195464000659	putative NTP binding site [chemical binding]; other site
1195464000660	putative nucleic acid binding site [nucleotide binding]; other site
1195464000661	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464000662	active site
1195464000663	glutamyl-tRNA synthetase; Provisional; Region: gltX; PRK14895
1195464000664	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1195464000665	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1195464000666	putative sugar binding sites [chemical binding]; other site
1195464000667	Q-X-W motif; other site
1195464000668	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
1195464000669	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1195464000670	Pleckstrin homology-like domain; Region: PH-like; cl17171
1195464000671	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1195464000672	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1195464000673	catalytic residue [active]
1195464000674	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464000675	AAA-like domain; Region: AAA_10; pfam12846
1195464000676	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1195464000677	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1195464000678	putative active site [active]
1195464000679	putative NTP binding site [chemical binding]; other site
1195464000680	putative nucleic acid binding site [nucleotide binding]; other site
1195464000681	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464000682	active site
1195464000683	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
1195464000684	Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466
1195464000685	Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; cl17750
1195464000686	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1195464000687	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464000688	Walker A motif; other site
1195464000689	ATP binding site [chemical binding]; other site
1195464000690	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1195464000691	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1195464000692	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1195464000693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1195464000694	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1195464000695	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1195464000696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000697	non-specific DNA binding site [nucleotide binding]; other site
1195464000698	salt bridge; other site
1195464000699	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000700	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464000701	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000702	non-specific DNA binding site [nucleotide binding]; other site
1195464000703	salt bridge; other site
1195464000704	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000705	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000706	non-specific DNA binding site [nucleotide binding]; other site
1195464000707	salt bridge; other site
1195464000708	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000709	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464000710	DNA binding residues [nucleotide binding]
1195464000711	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464000712	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1195464000713	Mg binding site [ion binding]; other site
1195464000714	nucleotide binding site [chemical binding]; other site
1195464000715	putative protofilament interface [polypeptide binding]; other site
1195464000716	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1195464000717	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1195464000718	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1195464000719	putative catalytic cysteine [active]
1195464000720	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1195464000721	putative active site [active]
1195464000722	metal binding site [ion binding]; metal-binding site
1195464000723	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1195464000724	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1195464000725	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464000726	FeS/SAM binding site; other site
1195464000727	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1195464000728	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1195464000729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464000730	FeS/SAM binding site; other site
1195464000731	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
1195464000732	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1195464000733	effector binding site; other site
1195464000734	active site
1195464000735	Zn binding site [ion binding]; other site
1195464000736	glycine loop; other site
1195464000737	YwiC-like protein; Region: YwiC; pfam14256
1195464000738	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464000739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464000740	S-adenosylmethionine binding site [chemical binding]; other site
1195464000741	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1195464000742	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464000743	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1195464000744	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1195464000745	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464000746	Rubredoxin [Energy production and conversion]; Region: COG1773
1195464000747	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1195464000748	iron binding site [ion binding]; other site
1195464000749	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1195464000750	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464000751	ligand binding site [chemical binding]; other site
1195464000752	flexible hinge region; other site
1195464000753	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1195464000754	putative switch regulator; other site
1195464000755	non-specific DNA interactions [nucleotide binding]; other site
1195464000756	DNA binding site [nucleotide binding]
1195464000757	sequence specific DNA binding site [nucleotide binding]; other site
1195464000758	putative cAMP binding site [chemical binding]; other site
1195464000759	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1195464000760	putative active site [active]
1195464000761	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1195464000762	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1195464000763	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1195464000764	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464000765	NAD binding site [chemical binding]; other site
1195464000766	dimer interface [polypeptide binding]; other site
1195464000767	substrate binding site [chemical binding]; other site
1195464000768	Fic/DOC family; Region: Fic; pfam02661
1195464000769	Fic family protein [Function unknown]; Region: COG3177
1195464000770	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
1195464000771	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1195464000772	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1195464000773	hexamer interface [polypeptide binding]; other site
1195464000774	ligand binding site [chemical binding]; other site
1195464000775	putative active site [active]
1195464000776	NAD(P) binding site [chemical binding]; other site
1195464000777	amino acid transporter; Region: 2A0306; TIGR00909
1195464000778	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1195464000779	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
1195464000780	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1195464000781	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464000782	nucleotide binding region [chemical binding]; other site
1195464000783	ATP-binding site [chemical binding]; other site
1195464000784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1195464000785	ATP binding site [chemical binding]; other site
1195464000786	Mg2+ binding site [ion binding]; other site
1195464000787	G-X-G motif; other site
1195464000788	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
1195464000789	GIY-YIG motif/motif A; other site
1195464000790	putative active site [active]
1195464000791	putative metal binding site [ion binding]; other site
1195464000792	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464000793	AAA domain; Region: AAA_21; pfam13304
1195464000794	Walker A/P-loop; other site
1195464000795	ATP binding site [chemical binding]; other site
1195464000796	AAA domain; Region: AAA_21; pfam13304
1195464000797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464000798	Walker B; other site
1195464000799	D-loop; other site
1195464000800	H-loop/switch region; other site
1195464000801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464000802	AAA domain; Region: AAA_21; pfam13304
1195464000803	Walker A/P-loop; other site
1195464000804	ATP binding site [chemical binding]; other site
1195464000805	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1195464000806	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464000807	active site
1195464000808	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464000809	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464000810	non-specific DNA binding site [nucleotide binding]; other site
1195464000811	salt bridge; other site
1195464000812	sequence-specific DNA binding site [nucleotide binding]; other site
1195464000813	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000814	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1195464000815	catalytic residues [active]
1195464000816	catalytic nucleophile [active]
1195464000817	Recombinase; Region: Recombinase; pfam07508
1195464000818	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464000819	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1195464000820	catalytic residues [active]
1195464000821	catalytic nucleophile [active]
1195464000822	Recombinase; Region: Recombinase; pfam07508
1195464000823	Peptidase M60-like family; Region: M60-like; pfam13402
1195464000824	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464000825	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464000826	Interdomain contacts; other site
1195464000827	Cytokine receptor motif; other site
1195464000828	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1195464000829	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
1195464000830	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
1195464000831	putative active site [active]
1195464000832	putative catalytic triad [active]
1195464000833	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
1195464000834	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464000835	FeS/SAM binding site; other site
1195464000836	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1195464000837	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464000838	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464000839	MarR family; Region: MarR_2; pfam12802
1195464000840	MarR family; Region: MarR_2; cl17246
1195464000841	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464000842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464000843	Coenzyme A binding pocket [chemical binding]; other site
1195464000844	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1195464000845	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1195464000846	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1195464000847	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1195464000848	FMN binding site [chemical binding]; other site
1195464000849	substrate binding site [chemical binding]; other site
1195464000850	putative catalytic residue [active]
1195464000851	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1195464000852	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464000853	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1195464000854	IHF dimer interface [polypeptide binding]; other site
1195464000855	IHF - DNA interface [nucleotide binding]; other site
1195464000856	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1195464000857	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1195464000858	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464000859	active site
1195464000860	catalytic site [active]
1195464000861	putative metal binding site [ion binding]; other site
1195464000862	hypothetical protein; Provisional; Region: PRK09273
1195464000863	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1195464000864	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464000865	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
1195464000866	active site
1195464000867	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464000868	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464000869	Interdomain contacts; other site
1195464000870	Cytokine receptor motif; other site
1195464000871	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464000872	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464000873	Interdomain contacts; other site
1195464000874	Cytokine receptor motif; other site
1195464000875	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
1195464000876	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1195464000877	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1195464000878	dimer interface [polypeptide binding]; other site
1195464000879	active site
1195464000880	metal binding site [ion binding]; metal-binding site
1195464000881	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
1195464000882	regulatory protein interface [polypeptide binding]; other site
1195464000883	active site
1195464000884	regulatory phosphorylation site [posttranslational modification]; other site
1195464000885	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1195464000886	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1195464000887	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1195464000888	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
1195464000889	active pocket/dimerization site; other site
1195464000890	active site
1195464000891	phosphorylation site [posttranslational modification]
1195464000892	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1195464000893	dimerization domain swap beta strand [polypeptide binding]; other site
1195464000894	regulatory protein interface [polypeptide binding]; other site
1195464000895	active site
1195464000896	regulatory phosphorylation site [posttranslational modification]; other site
1195464000897	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1195464000898	amphipathic channel; other site
1195464000899	Asn-Pro-Ala signature motifs; other site
1195464000900	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
1195464000901	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1195464000902	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1195464000903	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1195464000904	putative active site [active]
1195464000905	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1195464000906	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1195464000907	NAD binding site [chemical binding]; other site
1195464000908	sugar binding site [chemical binding]; other site
1195464000909	divalent metal binding site [ion binding]; other site
1195464000910	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464000911	dimer interface [polypeptide binding]; other site
1195464000912	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1195464000913	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1195464000914	active pocket/dimerization site; other site
1195464000915	active site
1195464000916	phosphorylation site [posttranslational modification]
1195464000917	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1195464000918	active site
1195464000919	phosphorylation site [posttranslational modification]
1195464000920	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1195464000921	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1195464000922	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1195464000923	Peptidase M60-like family; Region: M60-like; pfam13402
1195464000924	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464000925	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464000926	Interdomain contacts; other site
1195464000927	Cytokine receptor motif; other site
1195464000928	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1195464000929	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464000930	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464000931	Interdomain contacts; other site
1195464000932	Cytokine receptor motif; other site
1195464000933	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
1195464000934	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
1195464000935	nudix motif; other site
1195464000936	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1195464000937	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464000938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464000939	DNA binding residues [nucleotide binding]
1195464000940	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1195464000941	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464000942	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464000943	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1195464000944	VanZ like family; Region: VanZ; cl01971
1195464000945	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464000946	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464000947	Walker A/P-loop; other site
1195464000948	ATP binding site [chemical binding]; other site
1195464000949	Q-loop/lid; other site
1195464000950	ABC transporter signature motif; other site
1195464000951	Walker B; other site
1195464000952	D-loop; other site
1195464000953	H-loop/switch region; other site
1195464000954	FtsX-like permease family; Region: FtsX; pfam02687
1195464000955	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1195464000956	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1195464000957	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1195464000958	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1195464000959	catalytic residue [active]
1195464000960	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1195464000961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1195464000962	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1195464000963	Probable transposase; Region: OrfB_IS605; pfam01385
1195464000964	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1195464000965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464000966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464000967	dimer interface [polypeptide binding]; other site
1195464000968	phosphorylation site [posttranslational modification]
1195464000969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464000970	ATP binding site [chemical binding]; other site
1195464000971	Mg2+ binding site [ion binding]; other site
1195464000972	G-X-G motif; other site
1195464000973	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464000974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464000975	active site
1195464000976	phosphorylation site [posttranslational modification]
1195464000977	intermolecular recognition site; other site
1195464000978	dimerization interface [polypeptide binding]; other site
1195464000979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464000980	DNA binding site [nucleotide binding]
1195464000981	hypothetical protein; Provisional; Region: PRK06760; cl11698
1195464000982	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464000983	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464000984	Walker A/P-loop; other site
1195464000985	ATP binding site [chemical binding]; other site
1195464000986	Q-loop/lid; other site
1195464000987	ABC transporter signature motif; other site
1195464000988	Walker B; other site
1195464000989	D-loop; other site
1195464000990	H-loop/switch region; other site
1195464000991	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464000992	FtsX-like permease family; Region: FtsX; pfam02687
1195464000993	FtsX-like permease family; Region: FtsX; pfam02687
1195464000994	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
1195464000995	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1195464000996	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464000997	active site
1195464000998	motif I; other site
1195464000999	motif II; other site
1195464001000	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1195464001001	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1195464001002	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1195464001003	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1195464001004	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464001005	FtsX-like permease family; Region: FtsX; pfam02687
1195464001006	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1195464001007	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464001008	ligand binding site [chemical binding]; other site
1195464001009	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
1195464001010	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
1195464001011	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
1195464001012	active site
1195464001013	catalytic site [active]
1195464001014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001015	non-specific DNA binding site [nucleotide binding]; other site
1195464001016	salt bridge; other site
1195464001017	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001018	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464001019	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464001020	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464001021	Spore germination protein; Region: Spore_permease; cl17796
1195464001022	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464001023	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464001024	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464001025	amino acid carrier protein; Region: agcS; TIGR00835
1195464001026	glutaminase A; Region: Gln_ase; TIGR03814
1195464001027	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1195464001028	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1195464001029	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1195464001030	active site
1195464001031	catalytic residues [active]
1195464001032	DNA binding site [nucleotide binding]
1195464001033	Int/Topo IB signature motif; other site
1195464001034	Fic family protein [Function unknown]; Region: COG3177
1195464001035	Fic/DOC family; Region: Fic; pfam02661
1195464001036	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
1195464001037	putative ligand binding site [chemical binding]; other site
1195464001038	putative catalytic site [active]
1195464001039	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464001040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464001041	Walker A/P-loop; other site
1195464001042	ATP binding site [chemical binding]; other site
1195464001043	Q-loop/lid; other site
1195464001044	ABC transporter signature motif; other site
1195464001045	Walker B; other site
1195464001046	D-loop; other site
1195464001047	H-loop/switch region; other site
1195464001048	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1195464001049	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1195464001050	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1195464001051	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1195464001052	active site
1195464001053	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1195464001054	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1195464001055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464001056	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1195464001057	NAD(P) binding site [chemical binding]; other site
1195464001058	active site
1195464001059	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1195464001060	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1195464001061	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464001062	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464001063	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1195464001064	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1195464001065	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1195464001066	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1195464001067	dimer interface [polypeptide binding]; other site
1195464001068	active site
1195464001069	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1195464001070	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1195464001071	active site
1195464001072	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1195464001073	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1195464001074	substrate binding site; other site
1195464001075	tetramer interface; other site
1195464001076	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1195464001077	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1195464001078	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1195464001079	NAD binding site [chemical binding]; other site
1195464001080	substrate binding site [chemical binding]; other site
1195464001081	homodimer interface [polypeptide binding]; other site
1195464001082	active site
1195464001083	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1195464001084	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1195464001085	NADP binding site [chemical binding]; other site
1195464001086	active site
1195464001087	putative substrate binding site [chemical binding]; other site
1195464001088	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464001089	catalytic core [active]
1195464001090	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1195464001091	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464001092	active site
1195464001093	DNA binding site [nucleotide binding]
1195464001094	Int/Topo IB signature motif; other site
1195464001095	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1195464001096	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1195464001097	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1195464001098	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1195464001099	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464001100	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464001101	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464001102	Walker A/P-loop; other site
1195464001103	ATP binding site [chemical binding]; other site
1195464001104	Q-loop/lid; other site
1195464001105	ABC transporter signature motif; other site
1195464001106	Walker B; other site
1195464001107	D-loop; other site
1195464001108	H-loop/switch region; other site
1195464001109	Predicted transcriptional regulators [Transcription]; Region: COG1725
1195464001110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464001111	DNA-binding site [nucleotide binding]; DNA binding site
1195464001112	Cupin domain; Region: Cupin_2; cl17218
1195464001113	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1195464001114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464001115	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1195464001116	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1195464001117	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
1195464001118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464001119	dimerization interface [polypeptide binding]; other site
1195464001120	putative DNA binding site [nucleotide binding]; other site
1195464001121	putative Zn2+ binding site [ion binding]; other site
1195464001122	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464001123	FtsX-like permease family; Region: FtsX; pfam02687
1195464001124	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464001125	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464001126	Walker A/P-loop; other site
1195464001127	ATP binding site [chemical binding]; other site
1195464001128	Q-loop/lid; other site
1195464001129	ABC transporter signature motif; other site
1195464001130	Walker B; other site
1195464001131	D-loop; other site
1195464001132	H-loop/switch region; other site
1195464001133	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1195464001134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001135	ATP binding site [chemical binding]; other site
1195464001136	G-X-G motif; other site
1195464001137	FtsX-like permease family; Region: FtsX; pfam02687
1195464001138	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464001139	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464001140	Walker A/P-loop; other site
1195464001141	ATP binding site [chemical binding]; other site
1195464001142	Q-loop/lid; other site
1195464001143	ABC transporter signature motif; other site
1195464001144	Walker B; other site
1195464001145	D-loop; other site
1195464001146	H-loop/switch region; other site
1195464001147	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1195464001148	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
1195464001149	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1195464001150	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1195464001151	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1195464001152	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1195464001153	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1195464001154	PFEMP DBL domain; Region: PFEMP; pfam03011
1195464001155	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1195464001156	active site
1195464001157	phosphorylation site [posttranslational modification]
1195464001158	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1195464001159	HTH domain; Region: HTH_11; pfam08279
1195464001160	HTH domain; Region: HTH_11; pfam08279
1195464001161	PRD domain; Region: PRD; pfam00874
1195464001162	PRD domain; Region: PRD; pfam00874
1195464001163	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1195464001164	active site
1195464001165	P-loop; other site
1195464001166	phosphorylation site [posttranslational modification]
1195464001167	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1195464001168	active site
1195464001169	phosphorylation site [posttranslational modification]
1195464001170	Arginine repressor [Transcription]; Region: ArgR; COG1438
1195464001171	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1195464001172	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1195464001173	Fic family protein [Function unknown]; Region: COG3177
1195464001174	Fic/DOC family; Region: Fic; pfam02661
1195464001175	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464001176	NlpC/P60 family; Region: NLPC_P60; cl17555
1195464001177	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1195464001178	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1195464001179	tetramer interface [polypeptide binding]; other site
1195464001180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464001181	catalytic residue [active]
1195464001182	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1195464001183	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1195464001184	hexamer interface [polypeptide binding]; other site
1195464001185	ligand binding site [chemical binding]; other site
1195464001186	putative active site [active]
1195464001187	NAD(P) binding site [chemical binding]; other site
1195464001188	Replication-relaxation; Region: Replic_Relax; pfam13814
1195464001189	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1195464001190	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464001191	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464001192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001193	non-specific DNA binding site [nucleotide binding]; other site
1195464001194	salt bridge; other site
1195464001195	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001196	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
1195464001197	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464001198	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464001199	Interdomain contacts; other site
1195464001200	Cytokine receptor motif; other site
1195464001201	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
1195464001202	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1195464001203	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464001204	dimerization interface [polypeptide binding]; other site
1195464001205	putative DNA binding site [nucleotide binding]; other site
1195464001206	putative Zn2+ binding site [ion binding]; other site
1195464001207	putative transporter; Provisional; Region: PRK11660
1195464001208	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1195464001209	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1195464001210	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1195464001211	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1195464001212	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1195464001213	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1195464001214	PhnA protein; Region: PhnA; pfam03831
1195464001215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464001216	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1195464001217	putative substrate translocation pore; other site
1195464001218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1195464001219	MOSC domain; Region: MOSC; pfam03473
1195464001220	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
1195464001221	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464001222	DNA-binding site [nucleotide binding]; DNA binding site
1195464001223	FCD domain; Region: FCD; pfam07729
1195464001224	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464001225	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001226	non-specific DNA binding site [nucleotide binding]; other site
1195464001227	salt bridge; other site
1195464001228	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001229	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
1195464001230	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
1195464001231	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
1195464001232	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
1195464001233	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1195464001234	DNA-sulfur modification-associated; Region: DndB; cl17621
1195464001235	DGQHR domain; Region: DGQHR; TIGR03187
1195464001236	DNA-sulfur modification-associated; Region: DndB; cl17621
1195464001237	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1195464001238	RNAase interaction site [polypeptide binding]; other site
1195464001239	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464001240	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464001241	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1195464001242	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1195464001243	active site
1195464001244	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464001245	active site
1195464001246	DNA binding site [nucleotide binding]
1195464001247	Int/Topo IB signature motif; other site
1195464001248	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464001249	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1195464001250	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1195464001251	Restriction endonuclease; Region: Mrr_cat; pfam04471
1195464001252	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1195464001253	Toprim-like; Region: Toprim_2; pfam13155
1195464001254	DNA topoisomerase III; Provisional; Region: PRK07726
1195464001255	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1195464001256	active site
1195464001257	putative interdomain interaction site [polypeptide binding]; other site
1195464001258	putative metal-binding site [ion binding]; other site
1195464001259	putative nucleotide binding site [chemical binding]; other site
1195464001260	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464001261	domain I; other site
1195464001262	DNA binding groove [nucleotide binding]
1195464001263	phosphate binding site [ion binding]; other site
1195464001264	domain II; other site
1195464001265	domain III; other site
1195464001266	nucleotide binding site [chemical binding]; other site
1195464001267	catalytic site [active]
1195464001268	domain IV; other site
1195464001269	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464001270	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464001271	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464001272	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464001273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1195464001274	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1195464001275	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1195464001276	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1195464001277	MPN+ (JAMM) motif; other site
1195464001278	Zinc-binding site [ion binding]; other site
1195464001279	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464001280	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464001281	DNA binding site [nucleotide binding]
1195464001282	domain linker motif; other site
1195464001283	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1195464001284	dimerization interface [polypeptide binding]; other site
1195464001285	ligand binding site [chemical binding]; other site
1195464001286	polyol permease family; Region: 2A0118; TIGR00897
1195464001287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464001288	putative substrate translocation pore; other site
1195464001289	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1195464001290	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1195464001291	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1195464001292	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1195464001293	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1195464001294	substrate binding site [chemical binding]; other site
1195464001295	ATP binding site [chemical binding]; other site
1195464001296	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1195464001297	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1195464001298	tetrameric interface [polypeptide binding]; other site
1195464001299	NAD binding site [chemical binding]; other site
1195464001300	catalytic residues [active]
1195464001301	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1195464001302	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1195464001303	PYR/PP interface [polypeptide binding]; other site
1195464001304	dimer interface [polypeptide binding]; other site
1195464001305	TPP binding site [chemical binding]; other site
1195464001306	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1195464001307	Ph1570 protein; Region: Ph1570; pfam09638
1195464001308	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1195464001309	TPP-binding site; other site
1195464001310	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1195464001311	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1195464001312	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1195464001313	intersubunit interface [polypeptide binding]; other site
1195464001314	active site
1195464001315	zinc binding site [ion binding]; other site
1195464001316	Na+ binding site [ion binding]; other site
1195464001317	KduI/IolB family; Region: KduI; pfam04962
1195464001318	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1195464001319	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1195464001320	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464001321	TPR motif; other site
1195464001322	binding surface
1195464001323	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1195464001324	Protein of unknown function (DUF4046); Region: DUF4046; pfam13255
1195464001325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464001326	putative substrate translocation pore; other site
1195464001327	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1195464001328	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1195464001329	Tar ligand binding domain homologue; Region: TarH; pfam02203
1195464001330	Cache domain; Region: Cache_1; pfam02743
1195464001331	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464001332	dimerization interface [polypeptide binding]; other site
1195464001333	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464001334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464001335	dimer interface [polypeptide binding]; other site
1195464001336	putative CheW interface [polypeptide binding]; other site
1195464001337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464001338	TPR motif; other site
1195464001339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464001340	binding surface
1195464001341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464001342	TPR motif; other site
1195464001343	binding surface
1195464001344	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1195464001345	active site
1195464001346	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464001347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1195464001348	active site
1195464001349	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1195464001350	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464001351	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464001352	NAD(P) binding site [chemical binding]; other site
1195464001353	active site
1195464001354	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1195464001355	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1195464001356	inhibitor-cofactor binding pocket; inhibition site
1195464001357	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464001358	catalytic residue [active]
1195464001359	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
1195464001360	ligand binding site; other site
1195464001361	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
1195464001362	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1195464001363	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
1195464001364	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464001365	pseudaminic acid synthase; Region: PseI; TIGR03586
1195464001366	NeuB family; Region: NeuB; pfam03102
1195464001367	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1195464001368	NeuB binding interface [polypeptide binding]; other site
1195464001369	putative substrate binding site [chemical binding]; other site
1195464001370	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464001371	hypothetical protein; Provisional; Region: PRK06764
1195464001372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1195464001373	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1195464001374	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1195464001375	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1195464001376	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464001377	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1195464001378	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464001379	active site residue [active]
1195464001380	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464001381	active site residue [active]
1195464001382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464001383	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464001384	putative substrate translocation pore; other site
1195464001385	Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320
1195464001386	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1195464001387	Ca binding site [ion binding]; other site
1195464001388	active site
1195464001389	catalytic site [active]
1195464001390	Aamy_C domain; Region: Aamy_C; smart00632
1195464001391	IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604
1195464001392	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
1195464001393	starch-binding site 2 [chemical binding]; other site
1195464001394	starch-binding site 1 [chemical binding]; other site
1195464001395	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1195464001396	Putative esterase; Region: Esterase; pfam00756
1195464001397	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
1195464001398	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1195464001399	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1195464001400	acyl-activating enzyme (AAE) consensus motif; other site
1195464001401	AMP binding site [chemical binding]; other site
1195464001402	active site
1195464001403	CoA binding site [chemical binding]; other site
1195464001404	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464001405	S-methylmethionine transporter; Provisional; Region: PRK11387
1195464001406	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1195464001407	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1195464001408	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1195464001409	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1195464001410	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1195464001411	Probable transposase; Region: OrfB_IS605; pfam01385
1195464001412	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1195464001413	DoxX; Region: DoxX; pfam07681
1195464001414	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
1195464001415	putative active site [active]
1195464001416	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464001417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001418	active site
1195464001419	phosphorylation site [posttranslational modification]
1195464001420	intermolecular recognition site; other site
1195464001421	dimerization interface [polypeptide binding]; other site
1195464001422	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464001423	DNA binding site [nucleotide binding]
1195464001424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464001425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464001426	dimerization interface [polypeptide binding]; other site
1195464001427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464001428	dimer interface [polypeptide binding]; other site
1195464001429	phosphorylation site [posttranslational modification]
1195464001430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001431	ATP binding site [chemical binding]; other site
1195464001432	Mg2+ binding site [ion binding]; other site
1195464001433	G-X-G motif; other site
1195464001434	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464001435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464001436	putative DNA binding site [nucleotide binding]; other site
1195464001437	putative Zn2+ binding site [ion binding]; other site
1195464001438	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1195464001439	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1195464001440	NADP binding site [chemical binding]; other site
1195464001441	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1195464001442	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464001443	active site
1195464001444	DNA binding site [nucleotide binding]
1195464001445	Int/Topo IB signature motif; other site
1195464001446	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1195464001447	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
1195464001448	L-serine binding site [chemical binding]; other site
1195464001449	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1195464001450	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1195464001451	substrate-cofactor binding pocket; other site
1195464001452	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464001453	catalytic residue [active]
1195464001454	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464001455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464001456	Coenzyme A binding pocket [chemical binding]; other site
1195464001457	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1195464001458	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1195464001459	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464001460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464001461	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464001462	dimerization interface [polypeptide binding]; other site
1195464001463	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464001464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464001465	putative substrate translocation pore; other site
1195464001466	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1195464001467	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464001468	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464001469	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1195464001470	Methylamine utilisation protein MauE; Region: MauE; pfam07291
1195464001471	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
1195464001472	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464001473	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464001474	Walker A/P-loop; other site
1195464001475	ATP binding site [chemical binding]; other site
1195464001476	Q-loop/lid; other site
1195464001477	ABC transporter signature motif; other site
1195464001478	Walker B; other site
1195464001479	D-loop; other site
1195464001480	H-loop/switch region; other site
1195464001481	hypothetical protein; Provisional; Region: PRK08244
1195464001482	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1195464001483	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1195464001484	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464001485	Coenzyme A binding pocket [chemical binding]; other site
1195464001486	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
1195464001487	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1195464001488	active site
1195464001489	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1195464001490	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1195464001491	active site
1195464001492	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464001493	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001494	non-specific DNA binding site [nucleotide binding]; other site
1195464001495	salt bridge; other site
1195464001496	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001497	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
1195464001498	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1195464001499	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464001500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464001501	Coenzyme A binding pocket [chemical binding]; other site
1195464001502	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1195464001503	RNAase interaction site [polypeptide binding]; other site
1195464001504	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464001505	Histidine kinase; Region: HisKA_3; pfam07730
1195464001506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001507	ATP binding site [chemical binding]; other site
1195464001508	Mg2+ binding site [ion binding]; other site
1195464001509	G-X-G motif; other site
1195464001510	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464001511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001512	active site
1195464001513	phosphorylation site [posttranslational modification]
1195464001514	intermolecular recognition site; other site
1195464001515	dimerization interface [polypeptide binding]; other site
1195464001516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464001517	DNA binding residues [nucleotide binding]
1195464001518	dimerization interface [polypeptide binding]; other site
1195464001519	Putative sensor; Region: Sensor; pfam13796
1195464001520	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464001521	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464001522	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464001523	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464001524	S-layer homology domain; Region: SLH; pfam00395
1195464001525	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1195464001526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464001527	S-adenosylmethionine binding site [chemical binding]; other site
1195464001528	Fic/DOC family; Region: Fic; cl00960
1195464001529	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
1195464001530	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1195464001531	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464001532	active site
1195464001533	DNA binding site [nucleotide binding]
1195464001534	Int/Topo IB signature motif; other site
1195464001535	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464001536	DNA binding residues [nucleotide binding]
1195464001537	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1195464001538	DNA binding residues [nucleotide binding]
1195464001539	Domain of unknown function (DUF3994); Region: DUF3994; pfam13159
1195464001540	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1195464001541	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1195464001542	Probable transposase; Region: OrfB_IS605; pfam01385
1195464001543	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1195464001544	FtsX-like permease family; Region: FtsX; pfam02687
1195464001545	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464001546	Walker B; other site
1195464001547	D-loop; other site
1195464001548	H-loop/switch region; other site
1195464001549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464001550	dimerization interface [polypeptide binding]; other site
1195464001551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464001552	dimer interface [polypeptide binding]; other site
1195464001553	phosphorylation site [posttranslational modification]
1195464001554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001555	ATP binding site [chemical binding]; other site
1195464001556	Mg2+ binding site [ion binding]; other site
1195464001557	G-X-G motif; other site
1195464001558	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464001559	FtsX-like permease family; Region: FtsX; pfam02687
1195464001560	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464001561	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464001562	dimerization interface [polypeptide binding]; other site
1195464001563	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464001564	dimer interface [polypeptide binding]; other site
1195464001565	phosphorylation site [posttranslational modification]
1195464001566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001567	ATP binding site [chemical binding]; other site
1195464001568	Mg2+ binding site [ion binding]; other site
1195464001569	G-X-G motif; other site
1195464001570	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464001571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001572	active site
1195464001573	phosphorylation site [posttranslational modification]
1195464001574	intermolecular recognition site; other site
1195464001575	dimerization interface [polypeptide binding]; other site
1195464001576	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464001577	DNA binding site [nucleotide binding]
1195464001578	Transglycosylase; Region: Transgly; pfam00912
1195464001579	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1195464001580	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464001581	hypothetical protein; Provisional; Region: PRK06760; cl11698
1195464001582	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464001583	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464001584	Walker A/P-loop; other site
1195464001585	ATP binding site [chemical binding]; other site
1195464001586	Q-loop/lid; other site
1195464001587	ABC transporter signature motif; other site
1195464001588	Walker B; other site
1195464001589	D-loop; other site
1195464001590	H-loop/switch region; other site
1195464001591	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464001592	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1195464001593	dimer interface [polypeptide binding]; other site
1195464001594	phosphorylation site [posttranslational modification]
1195464001595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001596	ATP binding site [chemical binding]; other site
1195464001597	Mg2+ binding site [ion binding]; other site
1195464001598	G-X-G motif; other site
1195464001599	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464001600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001601	active site
1195464001602	phosphorylation site [posttranslational modification]
1195464001603	intermolecular recognition site; other site
1195464001604	dimerization interface [polypeptide binding]; other site
1195464001605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464001606	DNA binding site [nucleotide binding]
1195464001607	hypothetical protein; Provisional; Region: PRK10621
1195464001608	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464001609	Predicted transcriptional regulators [Transcription]; Region: COG1378
1195464001610	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1195464001611	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1195464001612	C-terminal domain interface [polypeptide binding]; other site
1195464001613	sugar binding site [chemical binding]; other site
1195464001614	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1195464001615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001616	non-specific DNA binding site [nucleotide binding]; other site
1195464001617	salt bridge; other site
1195464001618	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001619	Cupin domain; Region: Cupin_2; pfam07883
1195464001620	Protein of unknown function (DUF3902); Region: DUF3902; pfam13042
1195464001621	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
1195464001622	Birnavirus VP3 protein; Region: Birna_VP3; pfam01767
1195464001623	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1195464001624	IHF dimer interface [polypeptide binding]; other site
1195464001625	IHF - DNA interface [nucleotide binding]; other site
1195464001626	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
1195464001627	DHHW protein; Region: DHHW; pfam14286
1195464001628	DHHW protein; Region: DHHW; pfam14286
1195464001629	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1195464001630	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1195464001631	active site
1195464001632	catalytic triad [active]
1195464001633	oxyanion hole [active]
1195464001634	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1195464001635	active site
1195464001636	catalytic triad [active]
1195464001637	oxyanion hole [active]
1195464001638	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464001639	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1195464001640	NodB motif; other site
1195464001641	active site
1195464001642	catalytic site [active]
1195464001643	Zn binding site [ion binding]; other site
1195464001644	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464001645	dimerization interface [polypeptide binding]; other site
1195464001646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464001647	dimer interface [polypeptide binding]; other site
1195464001648	phosphorylation site [posttranslational modification]
1195464001649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001650	ATP binding site [chemical binding]; other site
1195464001651	Mg2+ binding site [ion binding]; other site
1195464001652	G-X-G motif; other site
1195464001653	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464001654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001655	active site
1195464001656	phosphorylation site [posttranslational modification]
1195464001657	intermolecular recognition site; other site
1195464001658	dimerization interface [polypeptide binding]; other site
1195464001659	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464001660	DNA binding site [nucleotide binding]
1195464001661	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1195464001662	DNA binding residues [nucleotide binding]
1195464001663	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464001664	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1195464001665	FtsX-like permease family; Region: FtsX; pfam02687
1195464001666	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464001667	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464001668	Walker A/P-loop; other site
1195464001669	ATP binding site [chemical binding]; other site
1195464001670	Q-loop/lid; other site
1195464001671	ABC transporter signature motif; other site
1195464001672	Walker B; other site
1195464001673	D-loop; other site
1195464001674	H-loop/switch region; other site
1195464001675	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464001676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001677	active site
1195464001678	phosphorylation site [posttranslational modification]
1195464001679	intermolecular recognition site; other site
1195464001680	dimerization interface [polypeptide binding]; other site
1195464001681	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464001682	DNA binding site [nucleotide binding]
1195464001683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464001684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001685	ATP binding site [chemical binding]; other site
1195464001686	Mg2+ binding site [ion binding]; other site
1195464001687	G-X-G motif; other site
1195464001688	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464001689	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1195464001690	CAAX protease self-immunity; Region: Abi; pfam02517
1195464001691	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464001692	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464001693	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464001694	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464001695	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464001696	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464001697	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464001698	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464001699	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464001700	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464001701	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464001702	dimerization interface [polypeptide binding]; other site
1195464001703	EamA-like transporter family; Region: EamA; pfam00892
1195464001704	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464001705	EamA-like transporter family; Region: EamA; pfam00892
1195464001706	M6 family metalloprotease domain; Region: M6dom_TIGR03296
1195464001707	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1195464001708	sugar binding site [chemical binding]; other site
1195464001709	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
1195464001710	Protein of unknown function (DUF975); Region: DUF975; cl10504
1195464001711	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial  homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613
1195464001712	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1195464001713	putative active site [active]
1195464001714	catalytic site [active]
1195464001715	putative metal binding site [ion binding]; other site
1195464001716	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1195464001717	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1195464001718	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1195464001719	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1195464001720	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464001721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464001722	Coenzyme A binding pocket [chemical binding]; other site
1195464001723	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1195464001724	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1195464001725	Cupin domain; Region: Cupin_2; pfam07883
1195464001726	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1195464001727	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1195464001728	active site
1195464001729	nucleotide binding site [chemical binding]; other site
1195464001730	HIGH motif; other site
1195464001731	KMSKS motif; other site
1195464001732	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
1195464001733	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464001734	Arginase family; Region: Arginase; cd09989
1195464001735	active site
1195464001736	Mn binding site [ion binding]; other site
1195464001737	oligomer interface [polypeptide binding]; other site
1195464001738	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1195464001739	Cupin domain; Region: Cupin_2; cl17218
1195464001740	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1195464001741	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1195464001742	Cu(I) binding site [ion binding]; other site
1195464001743	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
1195464001744	hypothetical protein; Provisional; Region: PRK06761
1195464001745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001746	non-specific DNA binding site [nucleotide binding]; other site
1195464001747	salt bridge; other site
1195464001748	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001749	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464001750	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464001751	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
1195464001752	hypothetical protein; Provisional; Region: PRK06770
1195464001753	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
1195464001754	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
1195464001755	Protein of unknown function (DUF3956); Region: DUF3956; pfam13104
1195464001756	Recombination protein U; Region: RecU; cl01314
1195464001757	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1195464001758	trimer interface [polypeptide binding]; other site
1195464001759	active site
1195464001760	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
1195464001761	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1195464001762	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
1195464001763	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001764	non-specific DNA binding site [nucleotide binding]; other site
1195464001765	salt bridge; other site
1195464001766	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001767	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464001768	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464001769	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
1195464001770	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
1195464001771	DNA binding residues [nucleotide binding]
1195464001772	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464001773	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
1195464001774	nucleotide binding site [chemical binding]; other site
1195464001775	Fibronectin type III protein; Region: DUF3672; pfam12421
1195464001776	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
1195464001777	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1195464001778	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1195464001779	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1195464001780	Helix-turn-helix domain; Region: HTH_38; pfam13936
1195464001781	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1195464001782	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464001783	DNA-binding site [nucleotide binding]; DNA binding site
1195464001784	FCD domain; Region: FCD; pfam07729
1195464001785	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1195464001786	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1195464001787	N- and C-terminal domain interface [polypeptide binding]; other site
1195464001788	active site
1195464001789	catalytic site [active]
1195464001790	metal binding site [ion binding]; metal-binding site
1195464001791	carbohydrate binding site [chemical binding]; other site
1195464001792	ATP binding site [chemical binding]; other site
1195464001793	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1195464001794	gluconate transporter; Region: gntP; TIGR00791
1195464001795	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1195464001796	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1195464001797	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1195464001798	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1195464001799	TcpE family; Region: TcpE; pfam12648
1195464001800	AAA-like domain; Region: AAA_10; pfam12846
1195464001801	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1195464001802	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
1195464001803	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
1195464001804	cell division protein DamX; Validated; Region: PRK10905
1195464001805	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1195464001806	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1195464001807	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1195464001808	catalytic residue [active]
1195464001809	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1195464001810	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464001811	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464001812	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1195464001813	RNA binding site [nucleotide binding]; other site
1195464001814	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
1195464001815	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464001816	dimerization interface [polypeptide binding]; other site
1195464001817	putative DNA binding site [nucleotide binding]; other site
1195464001818	putative Zn2+ binding site [ion binding]; other site
1195464001819	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464001820	DNA binding site [nucleotide binding]
1195464001821	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1195464001822	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464001823	Replication-relaxation; Region: Replic_Relax; pfam13814
1195464001824	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1195464001825	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1195464001826	catalytic residue [active]
1195464001827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464001828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464001829	dimerization interface [polypeptide binding]; other site
1195464001830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464001831	dimer interface [polypeptide binding]; other site
1195464001832	phosphorylation site [posttranslational modification]
1195464001833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464001834	ATP binding site [chemical binding]; other site
1195464001835	Mg2+ binding site [ion binding]; other site
1195464001836	G-X-G motif; other site
1195464001837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464001838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464001839	active site
1195464001840	phosphorylation site [posttranslational modification]
1195464001841	intermolecular recognition site; other site
1195464001842	dimerization interface [polypeptide binding]; other site
1195464001843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464001844	DNA binding site [nucleotide binding]
1195464001845	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
1195464001846	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1195464001847	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1195464001848	protein binding site [polypeptide binding]; other site
1195464001849	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1195464001850	FtsX-like permease family; Region: FtsX; pfam02687
1195464001851	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464001852	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464001853	Walker A/P-loop; other site
1195464001854	ATP binding site [chemical binding]; other site
1195464001855	Q-loop/lid; other site
1195464001856	ABC transporter signature motif; other site
1195464001857	Walker B; other site
1195464001858	D-loop; other site
1195464001859	H-loop/switch region; other site
1195464001860	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1195464001861	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1195464001862	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
1195464001863	putative active site [active]
1195464001864	putative catalytic triad [active]
1195464001865	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464001866	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1195464001867	active site
1195464001868	NTP binding site [chemical binding]; other site
1195464001869	metal binding triad [ion binding]; metal-binding site
1195464001870	antibiotic binding site [chemical binding]; other site
1195464001871	Protein of unknown function DUF86; Region: DUF86; pfam01934
1195464001872	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464001873	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464001874	dimer interface [polypeptide binding]; other site
1195464001875	putative CheW interface [polypeptide binding]; other site
1195464001876	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
1195464001877	IHF - DNA interface [nucleotide binding]; other site
1195464001878	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464001879	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464001880	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464001881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464001882	putative substrate translocation pore; other site
1195464001883	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1195464001884	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1195464001885	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1195464001886	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1195464001887	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
1195464001888	putative active site [active]
1195464001889	putative catalytic triad [active]
1195464001890	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1195464001891	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464001892	Interdomain contacts; other site
1195464001893	Cytokine receptor motif; other site
1195464001894	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1195464001895	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464001896	dimerization interface [polypeptide binding]; other site
1195464001897	putative DNA binding site [nucleotide binding]; other site
1195464001898	putative Zn2+ binding site [ion binding]; other site
1195464001899	YolD-like protein; Region: YolD; pfam08863
1195464001900	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1195464001901	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1195464001902	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1195464001903	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1195464001904	Probable transposase; Region: OrfB_IS605; pfam01385
1195464001905	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1195464001906	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
1195464001907	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1195464001908	catalytic residues [active]
1195464001909	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1195464001910	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1195464001911	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1195464001912	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001913	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1195464001914	non-specific DNA binding site [nucleotide binding]; other site
1195464001915	salt bridge; other site
1195464001916	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001917	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1195464001918	Catalytic site [active]
1195464001919	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001920	salt bridge; other site
1195464001921	non-specific DNA binding site [nucleotide binding]; other site
1195464001922	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001923	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
1195464001924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464001925	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1195464001926	Walker A motif; other site
1195464001927	ATP binding site [chemical binding]; other site
1195464001928	Walker B motif; other site
1195464001929	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
1195464001930	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464001931	positive control sigma-like factor; Validated; Region: PRK06930
1195464001932	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464001933	DNA binding residues [nucleotide binding]
1195464001934	Terminase-like family; Region: Terminase_6; pfam03237
1195464001935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
1195464001936	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
1195464001937	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1195464001938	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1195464001939	Phage capsid family; Region: Phage_capsid; pfam05065
1195464001940	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
1195464001941	Phage-related protein [Function unknown]; Region: COG5412
1195464001942	membrane protein P6; Region: PHA01399
1195464001943	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
1195464001944	Holin family; Region: Phage_holin_4; cl01989
1195464001945	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464001946	amidase catalytic site [active]
1195464001947	Zn binding residues [ion binding]; other site
1195464001948	substrate binding site [chemical binding]; other site
1195464001949	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464001950	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
1195464001951	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1195464001952	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1195464001953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464001954	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1195464001955	Walker A motif; other site
1195464001956	ATP binding site [chemical binding]; other site
1195464001957	Walker B motif; other site
1195464001958	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464001959	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1195464001960	Helix-turn-helix domain; Region: HTH_17; cl17695
1195464001961	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464001962	active site
1195464001963	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1195464001964	active site
1195464001965	8-oxo-dGMP binding site [chemical binding]; other site
1195464001966	nudix motif; other site
1195464001967	metal binding site [ion binding]; metal-binding site
1195464001968	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1195464001969	active site
1195464001970	8-oxo-dGMP binding site [chemical binding]; other site
1195464001971	nudix motif; other site
1195464001972	metal binding site [ion binding]; metal-binding site
1195464001973	Family description; Region: VCBS; pfam13517
1195464001974	Family description; Region: VCBS; pfam13517
1195464001975	Family description; Region: VCBS; pfam13517
1195464001976	Family description; Region: VCBS; pfam13517
1195464001977	Family description; Region: VCBS; pfam13517
1195464001978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464001979	Walker A/P-loop; other site
1195464001980	ATP binding site [chemical binding]; other site
1195464001981	AAA domain; Region: AAA_21; pfam13304
1195464001982	Rab family protein; Provisional; Region: PLN03118
1195464001983	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464001984	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1195464001985	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1195464001986	SIR2-like domain; Region: SIR2_2; pfam13289
1195464001987	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464001988	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464001989	non-specific DNA binding site [nucleotide binding]; other site
1195464001990	salt bridge; other site
1195464001991	sequence-specific DNA binding site [nucleotide binding]; other site
1195464001992	Replication initiation factor; Region: Rep_trans; pfam02486
1195464001993	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464001994	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1195464001995	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1195464001996	Int/Topo IB signature motif; other site
1195464001997	FOG: CBS domain [General function prediction only]; Region: COG0517
1195464001998	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1195464001999	Domain of unknown function (DUF3960); Region: DUF3960; pfam13142
1195464002000	Protein of unknown function (DUF3965); Region: DUF3965; pfam13112
1195464002001	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464002002	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464002003	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464002004	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464002005	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464002006	Putative transcription activator [Transcription]; Region: TenA; COG0819
1195464002007	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1195464002008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464002009	Q-loop/lid; other site
1195464002010	ABC transporter signature motif; other site
1195464002011	Walker B; other site
1195464002012	D-loop; other site
1195464002013	H-loop/switch region; other site
1195464002014	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1195464002015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464002016	dimer interface [polypeptide binding]; other site
1195464002017	conserved gate region; other site
1195464002018	putative PBP binding loops; other site
1195464002019	ABC-ATPase subunit interface; other site
1195464002020	NMT1/THI5 like; Region: NMT1; pfam09084
1195464002021	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1195464002022	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1195464002023	active site
1195464002024	thiamine phosphate binding site [chemical binding]; other site
1195464002025	pyrophosphate binding site [ion binding]; other site
1195464002026	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1195464002027	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1195464002028	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1195464002029	thiS-thiF/thiG interaction site; other site
1195464002030	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1195464002031	ThiS interaction site; other site
1195464002032	putative active site [active]
1195464002033	tetramer interface [polypeptide binding]; other site
1195464002034	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1195464002035	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1195464002036	ATP binding site [chemical binding]; other site
1195464002037	substrate interface [chemical binding]; other site
1195464002038	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1195464002039	dimer interface [polypeptide binding]; other site
1195464002040	substrate binding site [chemical binding]; other site
1195464002041	ATP binding site [chemical binding]; other site
1195464002042	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1195464002043	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1195464002044	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464002045	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1195464002046	potassium-transporting ATPase subunit C; Provisional; Region: PRK13997
1195464002047	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1195464002048	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1195464002049	Ligand Binding Site [chemical binding]; other site
1195464002050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002051	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464002052	putative substrate translocation pore; other site
1195464002053	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464002054	MarR family; Region: MarR; pfam01047
1195464002055	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1195464002056	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1195464002057	active site
1195464002058	nucleophile elbow; other site
1195464002059	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1195464002060	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464002061	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1195464002062	TM-ABC transporter signature motif; other site
1195464002063	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1195464002064	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1195464002065	Walker A/P-loop; other site
1195464002066	ATP binding site [chemical binding]; other site
1195464002067	Q-loop/lid; other site
1195464002068	ABC transporter signature motif; other site
1195464002069	Walker B; other site
1195464002070	D-loop; other site
1195464002071	H-loop/switch region; other site
1195464002072	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1195464002073	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1195464002074	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1195464002075	putative ligand binding site [chemical binding]; other site
1195464002076	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1195464002077	short chain dehydrogenase; Provisional; Region: PRK06701
1195464002078	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1195464002079	NAD binding site [chemical binding]; other site
1195464002080	metal binding site [ion binding]; metal-binding site
1195464002081	active site
1195464002082	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1195464002083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1195464002084	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1195464002085	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464002086	catalytic residues [active]
1195464002087	putative disulfide oxidoreductase; Provisional; Region: PRK03113
1195464002088	YhdB-like protein; Region: YhdB; pfam14148
1195464002089	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
1195464002090	Spore germination protein; Region: Spore_permease; pfam03845
1195464002091	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464002092	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464002093	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464002094	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1195464002095	putative FMN binding site [chemical binding]; other site
1195464002096	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1195464002097	SpoVR like protein; Region: SpoVR; pfam04293
1195464002098	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
1195464002099	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1195464002100	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464002101	putative DNA binding site [nucleotide binding]; other site
1195464002102	putative Zn2+ binding site [ion binding]; other site
1195464002103	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464002104	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
1195464002105	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
1195464002106	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1195464002107	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464002108	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464002109	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1195464002110	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
1195464002111	active site residue [active]
1195464002112	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1195464002113	putative homodimer interface [polypeptide binding]; other site
1195464002114	putative homotetramer interface [polypeptide binding]; other site
1195464002115	putative metal binding site [ion binding]; other site
1195464002116	putative homodimer-homodimer interface [polypeptide binding]; other site
1195464002117	putative allosteric switch controlling residues; other site
1195464002118	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1195464002119	CPxP  motif; other site
1195464002120	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464002121	active site residue [active]
1195464002122	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1195464002123	active site residue [active]
1195464002124	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464002125	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1195464002126	CPxP  motif; other site
1195464002127	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464002128	active site residue [active]
1195464002129	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464002130	active site residue [active]
1195464002131	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1195464002132	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464002133	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1195464002134	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
1195464002135	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1195464002136	NADP binding site [chemical binding]; other site
1195464002137	dimer interface [polypeptide binding]; other site
1195464002138	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1195464002139	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1195464002140	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1195464002141	PhoU domain; Region: PhoU; pfam01895
1195464002142	PhoU domain; Region: PhoU; pfam01895
1195464002143	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464002144	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1195464002145	putative NAD(P) binding site [chemical binding]; other site
1195464002146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002147	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464002148	putative substrate translocation pore; other site
1195464002149	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1195464002150	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1195464002151	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1195464002152	HTH domain; Region: HTH_11; pfam08279
1195464002153	Mga helix-turn-helix domain; Region: Mga; pfam05043
1195464002154	PRD domain; Region: PRD; pfam00874
1195464002155	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1195464002156	active site
1195464002157	P-loop; other site
1195464002158	phosphorylation site [posttranslational modification]
1195464002159	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1195464002160	active site
1195464002161	phosphorylation site [posttranslational modification]
1195464002162	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1195464002163	active site
1195464002164	methionine cluster; other site
1195464002165	phosphorylation site [posttranslational modification]
1195464002166	metal binding site [ion binding]; metal-binding site
1195464002167	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1195464002168	active site
1195464002169	P-loop; other site
1195464002170	phosphorylation site [posttranslational modification]
1195464002171	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1195464002172	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1195464002173	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1195464002174	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1195464002175	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464002176	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464002177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464002178	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1195464002179	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464002180	FtsX-like permease family; Region: FtsX; pfam02687
1195464002181	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464002182	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464002183	Walker A/P-loop; other site
1195464002184	ATP binding site [chemical binding]; other site
1195464002185	Q-loop/lid; other site
1195464002186	ABC transporter signature motif; other site
1195464002187	Walker B; other site
1195464002188	D-loop; other site
1195464002189	H-loop/switch region; other site
1195464002190	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1195464002191	HlyD family secretion protein; Region: HlyD_3; pfam13437
1195464002192	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
1195464002193	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1195464002194	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464002195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464002196	dimer interface [polypeptide binding]; other site
1195464002197	conserved gate region; other site
1195464002198	ABC-ATPase subunit interface; other site
1195464002199	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464002200	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1195464002201	dimanganese center [ion binding]; other site
1195464002202	CotJB protein; Region: CotJB; pfam12652
1195464002203	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1195464002204	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464002205	active site
1195464002206	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1195464002207	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1195464002208	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
1195464002209	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1195464002210	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464002211	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464002212	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
1195464002213	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
1195464002214	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464002215	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1195464002216	active site
1195464002217	metal binding site [ion binding]; metal-binding site
1195464002218	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464002219	Interdomain contacts; other site
1195464002220	Cytokine receptor motif; other site
1195464002221	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1195464002222	amino acid transporter; Region: 2A0306; TIGR00909
1195464002223	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1195464002224	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1195464002225	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1195464002226	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1195464002227	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1195464002228	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1195464002229	putative active site [active]
1195464002230	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1195464002231	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1195464002232	putative active site [active]
1195464002233	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1195464002234	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1195464002235	active site turn [active]
1195464002236	phosphorylation site [posttranslational modification]
1195464002237	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1195464002238	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1195464002239	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1195464002240	DoxX; Region: DoxX; pfam07681
1195464002241	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1195464002242	hypothetical protein; Provisional; Region: PRK06770
1195464002243	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464002244	EamA-like transporter family; Region: EamA; pfam00892
1195464002245	EamA-like transporter family; Region: EamA; pfam00892
1195464002246	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1195464002247	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1195464002248	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464002249	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464002250	Coenzyme A binding pocket [chemical binding]; other site
1195464002251	short chain dehydrogenase; Provisional; Region: PRK06924
1195464002252	classical (c) SDRs; Region: SDR_c; cd05233
1195464002253	NAD(P) binding site [chemical binding]; other site
1195464002254	active site
1195464002255	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1195464002256	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464002257	DNA binding residues [nucleotide binding]
1195464002258	putative dimer interface [polypeptide binding]; other site
1195464002259	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464002260	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464002261	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464002262	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1195464002263	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1195464002264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464002265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464002266	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464002267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002269	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464002270	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464002271	dimerization interface [polypeptide binding]; other site
1195464002272	putative DNA binding site [nucleotide binding]; other site
1195464002273	putative Zn2+ binding site [ion binding]; other site
1195464002274	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1195464002275	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464002276	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1195464002277	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1195464002278	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1195464002279	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1195464002280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464002282	putative substrate translocation pore; other site
1195464002283	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1195464002284	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1195464002285	proposed catalytic triad [active]
1195464002286	conserved cys residue [active]
1195464002287	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1195464002288	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1195464002289	Spore germination protein; Region: Spore_permease; cl17796
1195464002290	glutamate racemase; Provisional; Region: PRK00865
1195464002291	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
1195464002292	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1195464002293	tetrameric interface [polypeptide binding]; other site
1195464002294	activator binding site; other site
1195464002295	NADP binding site [chemical binding]; other site
1195464002296	substrate binding site [chemical binding]; other site
1195464002297	catalytic residues [active]
1195464002298	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464002299	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1195464002300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464002301	Walker A/P-loop; other site
1195464002302	ATP binding site [chemical binding]; other site
1195464002303	Q-loop/lid; other site
1195464002304	ABC transporter signature motif; other site
1195464002305	Walker B; other site
1195464002306	D-loop; other site
1195464002307	H-loop/switch region; other site
1195464002308	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464002309	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1195464002310	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1195464002311	Walker A/P-loop; other site
1195464002312	ATP binding site [chemical binding]; other site
1195464002313	Q-loop/lid; other site
1195464002314	ABC transporter signature motif; other site
1195464002315	Walker B; other site
1195464002316	D-loop; other site
1195464002317	H-loop/switch region; other site
1195464002318	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1195464002319	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464002320	substrate binding pocket [chemical binding]; other site
1195464002321	membrane-bound complex binding site; other site
1195464002322	hinge residues; other site
1195464002323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464002324	dimer interface [polypeptide binding]; other site
1195464002325	conserved gate region; other site
1195464002326	putative PBP binding loops; other site
1195464002327	ABC-ATPase subunit interface; other site
1195464002328	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1195464002329	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1195464002330	Walker A/P-loop; other site
1195464002331	ATP binding site [chemical binding]; other site
1195464002332	Q-loop/lid; other site
1195464002333	ABC transporter signature motif; other site
1195464002334	Walker B; other site
1195464002335	D-loop; other site
1195464002336	H-loop/switch region; other site
1195464002337	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1195464002338	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1195464002339	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1195464002340	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1195464002341	hypothetical protein; Provisional; Region: PRK13676
1195464002342	acetolactate synthase; Reviewed; Region: PRK08617
1195464002343	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1195464002344	PYR/PP interface [polypeptide binding]; other site
1195464002345	dimer interface [polypeptide binding]; other site
1195464002346	TPP binding site [chemical binding]; other site
1195464002347	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1195464002348	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1195464002349	TPP-binding site [chemical binding]; other site
1195464002350	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1195464002351	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1195464002352	active site
1195464002353	DNA binding site [nucleotide binding]
1195464002354	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1195464002355	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464002356	active site
1195464002357	motif I; other site
1195464002358	motif II; other site
1195464002359	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1195464002360	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1195464002361	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002362	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002363	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002364	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002365	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002366	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002367	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002368	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002369	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002370	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002371	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002372	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002373	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002374	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002375	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002376	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002377	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002378	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
1195464002379	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1195464002380	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1195464002381	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1195464002382	acyl-activating enzyme (AAE) consensus motif; other site
1195464002383	acyl-activating enzyme (AAE) consensus motif; other site
1195464002384	putative AMP binding site [chemical binding]; other site
1195464002385	putative active site [active]
1195464002386	putative CoA binding site [chemical binding]; other site
1195464002387	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1195464002388	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1195464002389	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1195464002390	enoyl-CoA hydratase; Provisional; Region: PRK07659
1195464002391	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1195464002392	substrate binding site [chemical binding]; other site
1195464002393	oxyanion hole (OAH) forming residues; other site
1195464002394	trimer interface [polypeptide binding]; other site
1195464002395	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
1195464002396	metal binding site [ion binding]; metal-binding site
1195464002397	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1195464002398	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1195464002399	putative oligomer interface [polypeptide binding]; other site
1195464002400	putative active site [active]
1195464002401	metal binding site [ion binding]; metal-binding site
1195464002402	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
1195464002403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464002404	S-adenosylmethionine binding site [chemical binding]; other site
1195464002405	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
1195464002406	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
1195464002407	carbon starvation induced protein; Validated; Region: PRK02963
1195464002408	substrate binding pocket [chemical binding]; other site
1195464002409	active site
1195464002410	iron coordination sites [ion binding]; other site
1195464002411	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1195464002412	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1195464002413	proline racemase; Provisional; Region: PRK13969
1195464002414	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1195464002415	ornithine cyclodeaminase; Validated; Region: PRK08618
1195464002416	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1195464002417	NAD(P) binding site [chemical binding]; other site
1195464002418	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1195464002419	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1195464002420	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464002421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464002422	dimer interface [polypeptide binding]; other site
1195464002423	conserved gate region; other site
1195464002424	putative PBP binding loops; other site
1195464002425	ABC-ATPase subunit interface; other site
1195464002426	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1195464002427	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1195464002428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464002429	dimer interface [polypeptide binding]; other site
1195464002430	conserved gate region; other site
1195464002431	putative PBP binding loops; other site
1195464002432	ABC-ATPase subunit interface; other site
1195464002433	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1195464002434	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464002435	Walker A/P-loop; other site
1195464002436	ATP binding site [chemical binding]; other site
1195464002437	Q-loop/lid; other site
1195464002438	ABC transporter signature motif; other site
1195464002439	Walker B; other site
1195464002440	D-loop; other site
1195464002441	H-loop/switch region; other site
1195464002442	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1195464002443	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1195464002444	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464002445	Walker A/P-loop; other site
1195464002446	ATP binding site [chemical binding]; other site
1195464002447	Q-loop/lid; other site
1195464002448	ABC transporter signature motif; other site
1195464002449	Walker B; other site
1195464002450	D-loop; other site
1195464002451	H-loop/switch region; other site
1195464002452	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1195464002453	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1195464002454	Protein of unknown function, DUF600; Region: DUF600; pfam04634
1195464002455	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1195464002456	nucleophilic elbow; other site
1195464002457	catalytic triad; other site
1195464002458	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
1195464002459	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1195464002460	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1195464002461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002462	putative substrate translocation pore; other site
1195464002463	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1195464002464	PAS domain; Region: PAS; smart00091
1195464002465	putative active site [active]
1195464002466	heme pocket [chemical binding]; other site
1195464002467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464002468	ATP binding site [chemical binding]; other site
1195464002469	Mg2+ binding site [ion binding]; other site
1195464002470	G-X-G motif; other site
1195464002471	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1195464002472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464002473	active site
1195464002474	phosphorylation site [posttranslational modification]
1195464002475	intermolecular recognition site; other site
1195464002476	dimerization interface [polypeptide binding]; other site
1195464002477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1195464002478	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1195464002479	active site
1195464002480	8-oxo-dGMP binding site [chemical binding]; other site
1195464002481	nudix motif; other site
1195464002482	metal binding site [ion binding]; metal-binding site
1195464002483	PLD-like domain; Region: PLDc_2; pfam13091
1195464002484	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1195464002485	putative homodimer interface [polypeptide binding]; other site
1195464002486	putative active site [active]
1195464002487	catalytic site [active]
1195464002488	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1195464002489	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464002490	ATP binding site [chemical binding]; other site
1195464002491	putative Mg++ binding site [ion binding]; other site
1195464002492	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464002493	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1195464002494	nucleotide binding region [chemical binding]; other site
1195464002495	ATP-binding site [chemical binding]; other site
1195464002496	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1195464002497	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
1195464002498	metal binding site [ion binding]; metal-binding site
1195464002499	Helix-turn-helix domain; Region: HTH_36; pfam13730
1195464002500	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1195464002501	replicative DNA helicase; Provisional; Region: PRK06749
1195464002502	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1195464002503	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1195464002504	Walker A motif; other site
1195464002505	ATP binding site [chemical binding]; other site
1195464002506	Walker B motif; other site
1195464002507	DNA binding loops [nucleotide binding]
1195464002508	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1195464002509	Predicted transcriptional regulators [Transcription]; Region: COG1378
1195464002510	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1195464002511	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1195464002512	C-terminal domain interface [polypeptide binding]; other site
1195464002513	sugar binding site [chemical binding]; other site
1195464002514	hypothetical protein; Provisional; Region: PRK10621
1195464002515	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464002516	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464002517	EamA-like transporter family; Region: EamA; pfam00892
1195464002518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464002519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464002520	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1195464002521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002522	putative substrate translocation pore; other site
1195464002523	Predicted permease; Region: DUF318; cl17795
1195464002524	Predicted permease; Region: DUF318; cl17795
1195464002525	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464002526	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464002527	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464002528	amidase catalytic site [active]
1195464002529	Zn binding residues [ion binding]; other site
1195464002530	substrate binding site [chemical binding]; other site
1195464002531	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464002532	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464002533	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1195464002534	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
1195464002535	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1195464002536	CAT RNA binding domain; Region: CAT_RBD; smart01061
1195464002537	PRD domain; Region: PRD; pfam00874
1195464002538	PRD domain; Region: PRD; pfam00874
1195464002539	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
1195464002540	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1195464002541	active site turn [active]
1195464002542	phosphorylation site [posttranslational modification]
1195464002543	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1195464002544	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1195464002545	HPr interaction site; other site
1195464002546	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1195464002547	active site
1195464002548	phosphorylation site [posttranslational modification]
1195464002549	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1195464002550	beta-galactosidase; Region: BGL; TIGR03356
1195464002551	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1195464002552	MarR family; Region: MarR_2; pfam12802
1195464002553	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1195464002554	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1195464002555	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1195464002556	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464002557	non-specific DNA binding site [nucleotide binding]; other site
1195464002558	salt bridge; other site
1195464002559	sequence-specific DNA binding site [nucleotide binding]; other site
1195464002560	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464002561	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464002562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464002563	putative substrate translocation pore; other site
1195464002564	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464002565	putative DNA binding site [nucleotide binding]; other site
1195464002566	dimerization interface [polypeptide binding]; other site
1195464002567	putative Zn2+ binding site [ion binding]; other site
1195464002568	VanZ like family; Region: VanZ; pfam04892
1195464002569	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
1195464002570	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
1195464002571	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1195464002572	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1195464002573	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464002574	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1195464002575	dihydroxyacetone kinase; Provisional; Region: PRK14479
1195464002576	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1195464002577	DAK2 domain; Region: Dak2; pfam02734
1195464002578	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1195464002579	Predicted transcriptional regulator [Transcription]; Region: COG1959
1195464002580	Transcriptional regulator; Region: Rrf2; pfam02082
1195464002581	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1195464002582	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1195464002583	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
1195464002584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464002585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464002586	active site
1195464002587	phosphorylation site [posttranslational modification]
1195464002588	intermolecular recognition site; other site
1195464002589	dimerization interface [polypeptide binding]; other site
1195464002590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464002591	DNA binding site [nucleotide binding]
1195464002592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464002593	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464002594	dimerization interface [polypeptide binding]; other site
1195464002595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464002596	dimer interface [polypeptide binding]; other site
1195464002597	phosphorylation site [posttranslational modification]
1195464002598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464002599	ATP binding site [chemical binding]; other site
1195464002600	G-X-G motif; other site
1195464002601	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464002602	TPR motif; other site
1195464002603	binding surface
1195464002604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1195464002605	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
1195464002606	Heat induced stress protein YflT; Region: YflT; pfam11181
1195464002607	Predicted membrane protein [Function unknown]; Region: COG2261
1195464002608	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1195464002609	anti sigma factor interaction site; other site
1195464002610	regulatory phosphorylation site [posttranslational modification]; other site
1195464002611	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1195464002612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464002613	ATP binding site [chemical binding]; other site
1195464002614	Mg2+ binding site [ion binding]; other site
1195464002615	G-X-G motif; other site
1195464002616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464002617	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1195464002618	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464002619	DNA binding residues [nucleotide binding]
1195464002620	Ferritin-like domain; Region: Ferritin; pfam00210
1195464002621	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1195464002622	dinuclear metal binding motif [ion binding]; other site
1195464002623	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1195464002624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464002625	active site
1195464002626	phosphorylation site [posttranslational modification]
1195464002627	intermolecular recognition site; other site
1195464002628	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1195464002629	dimerization interface [polypeptide binding]; other site
1195464002630	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1195464002631	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1195464002632	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1195464002633	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1195464002634	CHASE3 domain; Region: CHASE3; pfam05227
1195464002635	GAF domain; Region: GAF; pfam01590
1195464002636	GAF domain; Region: GAF_2; pfam13185
1195464002637	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464002638	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464002639	dimer interface [polypeptide binding]; other site
1195464002640	phosphorylation site [posttranslational modification]
1195464002641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464002642	ATP binding site [chemical binding]; other site
1195464002643	Mg2+ binding site [ion binding]; other site
1195464002644	G-X-G motif; other site
1195464002645	Response regulator receiver domain; Region: Response_reg; pfam00072
1195464002646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464002647	active site
1195464002648	phosphorylation site [posttranslational modification]
1195464002649	intermolecular recognition site; other site
1195464002650	dimerization interface [polypeptide binding]; other site
1195464002651	regulatory protein interface [polypeptide binding]; other site
1195464002652	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
1195464002653	regulatory phosphorylation site [posttranslational modification]; other site
1195464002654	Protein of unknown function (DUF4028); Region: DUF4028; pfam13220
1195464002655	hypothetical protein; Provisional; Region: PRK12856
1195464002656	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
1195464002657	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464002658	NADP binding site [chemical binding]; other site
1195464002659	dimer interface [polypeptide binding]; other site
1195464002660	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
1195464002661	YhzD-like protein; Region: YhzD; pfam14120
1195464002662	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1195464002663	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464002664	active site
1195464002665	metal binding site [ion binding]; metal-binding site
1195464002666	DNA binding site [nucleotide binding]
1195464002667	AAA domain; Region: AAA_27; pfam13514
1195464002668	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1195464002669	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1195464002670	generic binding surface II; other site
1195464002671	generic binding surface I; other site
1195464002672	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464002673	Zn2+ binding site [ion binding]; other site
1195464002674	Mg2+ binding site [ion binding]; other site
1195464002675	MoxR-like ATPases [General function prediction only]; Region: COG0714
1195464002676	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1195464002677	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464002678	Zn binding site [ion binding]; other site
1195464002679	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1195464002680	Zn binding site [ion binding]; other site
1195464002681	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1195464002682	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464002683	Zn binding site [ion binding]; other site
1195464002684	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1195464002685	Zn binding site [ion binding]; other site
1195464002686	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
1195464002687	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464002688	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1195464002689	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
1195464002690	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464002691	non-specific DNA binding site [nucleotide binding]; other site
1195464002692	salt bridge; other site
1195464002693	sequence-specific DNA binding site [nucleotide binding]; other site
1195464002694	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
1195464002695	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1195464002696	amphipathic channel; other site
1195464002697	Asn-Pro-Ala signature motifs; other site
1195464002698	glycerol kinase; Provisional; Region: glpK; PRK00047
1195464002699	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1195464002700	N- and C-terminal domain interface [polypeptide binding]; other site
1195464002701	active site
1195464002702	MgATP binding site [chemical binding]; other site
1195464002703	catalytic site [active]
1195464002704	metal binding site [ion binding]; metal-binding site
1195464002705	glycerol binding site [chemical binding]; other site
1195464002706	homotetramer interface [polypeptide binding]; other site
1195464002707	homodimer interface [polypeptide binding]; other site
1195464002708	FBP binding site [chemical binding]; other site
1195464002709	protein IIAGlc interface [polypeptide binding]; other site
1195464002710	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1195464002711	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
1195464002712	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464002713	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464002714	DNA binding residues [nucleotide binding]
1195464002715	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
1195464002716	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464002717	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1195464002718	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1195464002719	Part of AAA domain; Region: AAA_19; pfam13245
1195464002720	Family description; Region: UvrD_C_2; pfam13538
1195464002721	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
1195464002722	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1195464002723	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
1195464002724	transcriptional regulator Hpr; Provisional; Region: PRK13777
1195464002725	MarR family; Region: MarR; pfam01047
1195464002726	YtxH-like protein; Region: YtxH; cl02079
1195464002727	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1195464002728	HIT family signature motif; other site
1195464002729	catalytic residue [active]
1195464002730	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464002731	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464002732	Walker A/P-loop; other site
1195464002733	ATP binding site [chemical binding]; other site
1195464002734	Q-loop/lid; other site
1195464002735	ABC transporter signature motif; other site
1195464002736	Walker B; other site
1195464002737	D-loop; other site
1195464002738	H-loop/switch region; other site
1195464002739	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1195464002740	EcsC protein family; Region: EcsC; pfam12787
1195464002741	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464002742	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464002743	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1195464002744	Predicted membrane protein [Function unknown]; Region: COG3428
1195464002745	Bacterial PH domain; Region: DUF304; pfam03703
1195464002746	Bacterial PH domain; Region: DUF304; pfam03703
1195464002747	Protein of unknown function (DUF975); Region: DUF975; pfam06161
1195464002748	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
1195464002749	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464002750	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464002751	Collagen binding domain; Region: Collagen_bind; pfam05737
1195464002752	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1195464002753	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002754	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002755	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002756	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002757	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002758	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1195464002759	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002760	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002761	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002762	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002763	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002764	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002765	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002766	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002767	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002768	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002769	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002770	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002771	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002772	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002773	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464002774	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
1195464002775	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1195464002776	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1195464002777	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1195464002778	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464002779	DNA binding residues [nucleotide binding]
1195464002780	drug binding residues [chemical binding]; other site
1195464002781	dimer interface [polypeptide binding]; other site
1195464002782	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1195464002783	Bacterial PH domain; Region: DUF304; pfam03703
1195464002784	Bacterial PH domain; Region: DUF304; pfam03703
1195464002785	Bacterial PH domain; Region: DUF304; pfam03703
1195464002786	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1195464002787	Transglycosylase; Region: Transgly; pfam00912
1195464002788	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1195464002789	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464002790	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1195464002791	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1195464002792	substrate binding site [chemical binding]; other site
1195464002793	active site
1195464002794	ferrochelatase; Provisional; Region: PRK12435
1195464002795	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1195464002796	C-terminal domain interface [polypeptide binding]; other site
1195464002797	active site
1195464002798	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1195464002799	active site
1195464002800	N-terminal domain interface [polypeptide binding]; other site
1195464002801	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1195464002802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464002803	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464002804	Fn3 associated; Region: Fn3_assoc; pfam13287
1195464002805	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1195464002806	generic binding surface II; other site
1195464002807	generic binding surface I; other site
1195464002808	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1195464002809	putative active site [active]
1195464002810	putative catalytic site [active]
1195464002811	putative Mg binding site IVb [ion binding]; other site
1195464002812	putative phosphate binding site [ion binding]; other site
1195464002813	putative DNA binding site [nucleotide binding]; other site
1195464002814	putative Mg binding site IVa [ion binding]; other site
1195464002815	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1195464002816	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1195464002817	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464002818	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464002819	Predicted membrane protein [Function unknown]; Region: COG1511
1195464002820	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1195464002821	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1195464002822	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1195464002823	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1195464002824	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464002825	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464002826	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1195464002827	HTH domain; Region: HTH_11; cl17392
1195464002828	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464002829	DNA binding site [nucleotide binding]
1195464002830	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1195464002831	domain linker motif; other site
1195464002832	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1195464002833	putative dimerization interface [polypeptide binding]; other site
1195464002834	putative ligand binding site [chemical binding]; other site
1195464002835	YhfH-like protein; Region: YhfH; pfam14149
1195464002836	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1195464002837	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1195464002838	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1195464002839	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1195464002840	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1195464002841	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1195464002842	acyl-activating enzyme (AAE) consensus motif; other site
1195464002843	putative AMP binding site [chemical binding]; other site
1195464002844	putative active site [active]
1195464002845	putative CoA binding site [chemical binding]; other site
1195464002846	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1195464002847	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464002848	putative active site [active]
1195464002849	putative metal binding site [ion binding]; other site
1195464002850	CAAX protease self-immunity; Region: Abi; pfam02517
1195464002851	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1195464002852	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464002853	Zn2+ binding site [ion binding]; other site
1195464002854	Mg2+ binding site [ion binding]; other site
1195464002855	Putative zinc-finger; Region: zf-HC2; pfam13490
1195464002856	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1195464002857	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1195464002858	RNA polymerase sigma factor; Provisional; Region: PRK12541
1195464002859	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464002860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464002861	DNA binding residues [nucleotide binding]
1195464002862	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464002863	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1195464002864	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464002865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1195464002866	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1195464002867	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464002868	active site
1195464002869	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464002870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464002871	dimer interface [polypeptide binding]; other site
1195464002872	phosphorylation site [posttranslational modification]
1195464002873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464002874	ATP binding site [chemical binding]; other site
1195464002875	Mg2+ binding site [ion binding]; other site
1195464002876	G-X-G motif; other site
1195464002877	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464002878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464002879	active site
1195464002880	phosphorylation site [posttranslational modification]
1195464002881	intermolecular recognition site; other site
1195464002882	dimerization interface [polypeptide binding]; other site
1195464002883	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464002884	DNA binding site [nucleotide binding]
1195464002885	CAAX protease self-immunity; Region: Abi; pfam02517
1195464002886	Peptidase family M48; Region: Peptidase_M48; pfam01435
1195464002887	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1195464002888	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464002889	dimerization interface [polypeptide binding]; other site
1195464002890	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464002891	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464002892	dimer interface [polypeptide binding]; other site
1195464002893	putative CheW interface [polypeptide binding]; other site
1195464002894	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464002895	EamA-like transporter family; Region: EamA; pfam00892
1195464002896	EamA-like transporter family; Region: EamA; pfam00892
1195464002897	malate synthase A; Region: malate_syn_A; TIGR01344
1195464002898	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1195464002899	active site
1195464002900	isocitrate lyase; Provisional; Region: PRK15063
1195464002901	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1195464002902	tetramer interface [polypeptide binding]; other site
1195464002903	active site
1195464002904	Mg2+/Mn2+ binding site [ion binding]; other site
1195464002905	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1195464002906	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464002907	active site
1195464002908	substrate binding site [chemical binding]; other site
1195464002909	ATP binding site [chemical binding]; other site
1195464002910	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1195464002911	DNA-binding site [nucleotide binding]; DNA binding site
1195464002912	RNA-binding motif; other site
1195464002913	ComK protein; Region: ComK; pfam06338
1195464002914	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1195464002915	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464002916	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1195464002917	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464002918	Catalytic site [active]
1195464002919	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
1195464002920	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1195464002921	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1195464002922	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1195464002923	Part of AAA domain; Region: AAA_19; pfam13245
1195464002924	Family description; Region: UvrD_C_2; pfam13538
1195464002925	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1195464002926	hypothetical protein; Provisional; Region: PRK07758
1195464002927	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1195464002928	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1195464002929	Spore germination protein GerPC; Region: GerPC; pfam10737
1195464002930	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
1195464002931	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1195464002932	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1195464002933	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1195464002934	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1195464002935	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1195464002936	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464002937	inhibitor-cofactor binding pocket; inhibition site
1195464002938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464002939	catalytic residue [active]
1195464002940	hypothetical protein; Provisional; Region: PRK13673
1195464002941	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
1195464002942	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1195464002943	active site
1195464002944	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1195464002945	dimer interface [polypeptide binding]; other site
1195464002946	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1195464002947	Ligand Binding Site [chemical binding]; other site
1195464002948	Molecular Tunnel; other site
1195464002949	ferrochelatase; Provisional; Region: PRK12435
1195464002950	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1195464002951	C-terminal domain interface [polypeptide binding]; other site
1195464002952	active site
1195464002953	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1195464002954	active site
1195464002955	N-terminal domain interface [polypeptide binding]; other site
1195464002956	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1195464002957	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1195464002958	tetramer interface [polypeptide binding]; other site
1195464002959	heme binding pocket [chemical binding]; other site
1195464002960	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1195464002961	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1195464002962	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1195464002963	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1195464002964	active site
1195464002965	catalytic site [active]
1195464002966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1195464002967	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1195464002968	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1195464002969	S1 domain; Region: S1_2; pfam13509
1195464002970	RHS Repeat; Region: RHS_repeat; cl11982
1195464002971	RHS protein; Region: RHS; pfam03527
1195464002972	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1195464002973	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
1195464002974	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1195464002975	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464002976	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464002977	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464002978	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
1195464002979	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464002980	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464002981	active site
1195464002982	motif I; other site
1195464002983	motif II; other site
1195464002984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1195464002985	YjzC-like protein; Region: YjzC; pfam14168
1195464002986	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1195464002987	Clp amino terminal domain; Region: Clp_N; pfam02861
1195464002988	Clp amino terminal domain; Region: Clp_N; pfam02861
1195464002989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464002990	Walker A motif; other site
1195464002991	ATP binding site [chemical binding]; other site
1195464002992	Walker B motif; other site
1195464002993	arginine finger; other site
1195464002994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464002995	Walker A motif; other site
1195464002996	ATP binding site [chemical binding]; other site
1195464002997	Walker B motif; other site
1195464002998	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1195464002999	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1195464003000	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464003001	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464003002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464003003	ComZ; Region: ComZ; pfam10815
1195464003004	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1195464003005	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1195464003006	dimer interface [polypeptide binding]; other site
1195464003007	active site
1195464003008	CoA binding pocket [chemical binding]; other site
1195464003009	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1195464003010	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1195464003011	dimer interface [polypeptide binding]; other site
1195464003012	active site
1195464003013	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
1195464003014	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
1195464003015	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1195464003016	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1195464003017	active site
1195464003018	HIGH motif; other site
1195464003019	dimer interface [polypeptide binding]; other site
1195464003020	KMSKS motif; other site
1195464003021	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
1195464003022	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464003023	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464003024	peptide binding site [polypeptide binding]; other site
1195464003025	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464003026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464003027	dimer interface [polypeptide binding]; other site
1195464003028	conserved gate region; other site
1195464003029	putative PBP binding loops; other site
1195464003030	ABC-ATPase subunit interface; other site
1195464003031	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1195464003032	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1195464003033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464003034	dimer interface [polypeptide binding]; other site
1195464003035	conserved gate region; other site
1195464003036	putative PBP binding loops; other site
1195464003037	ABC-ATPase subunit interface; other site
1195464003038	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1195464003039	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464003040	Walker A/P-loop; other site
1195464003041	ATP binding site [chemical binding]; other site
1195464003042	Q-loop/lid; other site
1195464003043	ABC transporter signature motif; other site
1195464003044	Walker B; other site
1195464003045	D-loop; other site
1195464003046	H-loop/switch region; other site
1195464003047	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1195464003048	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1195464003049	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464003050	Walker A/P-loop; other site
1195464003051	ATP binding site [chemical binding]; other site
1195464003052	Q-loop/lid; other site
1195464003053	ABC transporter signature motif; other site
1195464003054	Walker B; other site
1195464003055	D-loop; other site
1195464003056	H-loop/switch region; other site
1195464003057	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1195464003058	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1195464003059	active site
1195464003060	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1195464003061	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1195464003062	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464003063	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464003064	peptide binding site [polypeptide binding]; other site
1195464003065	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1195464003066	ArsC family; Region: ArsC; pfam03960
1195464003067	putative catalytic residues [active]
1195464003068	thiol/disulfide switch; other site
1195464003069	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1195464003070	adaptor protein; Provisional; Region: PRK02315
1195464003071	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1195464003072	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1195464003073	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1195464003074	putative active site [active]
1195464003075	catalytic site [active]
1195464003076	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1195464003077	putative active site [active]
1195464003078	catalytic site [active]
1195464003079	Competence protein CoiA-like family; Region: CoiA; cl11541
1195464003080	oligoendopeptidase F; Region: pepF; TIGR00181
1195464003081	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1195464003082	active site
1195464003083	Zn binding site [ion binding]; other site
1195464003084	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1195464003085	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1195464003086	catalytic residues [active]
1195464003087	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1195464003088	apolar tunnel; other site
1195464003089	heme binding site [chemical binding]; other site
1195464003090	dimerization interface [polypeptide binding]; other site
1195464003091	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1195464003092	putative active site [active]
1195464003093	putative metal binding residues [ion binding]; other site
1195464003094	signature motif; other site
1195464003095	putative triphosphate binding site [ion binding]; other site
1195464003096	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1195464003097	synthetase active site [active]
1195464003098	NTP binding site [chemical binding]; other site
1195464003099	metal binding site [ion binding]; metal-binding site
1195464003100	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1195464003101	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1195464003102	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1195464003103	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1195464003104	active site
1195464003105	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1195464003106	trimer interface [polypeptide binding]; other site
1195464003107	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
1195464003108	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
1195464003109	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
1195464003110	active site
1195464003111	metal binding site [ion binding]; metal-binding site
1195464003112	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1195464003113	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464003114	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464003115	active site
1195464003116	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464003117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464003118	S-adenosylmethionine binding site [chemical binding]; other site
1195464003119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1195464003120	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464003121	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464003122	binding surface
1195464003123	TPR motif; other site
1195464003124	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464003125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464003126	S-adenosylmethionine binding site [chemical binding]; other site
1195464003127	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1195464003128	catalytic residues [active]
1195464003129	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
1195464003130	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
1195464003131	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1195464003132	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1195464003133	substrate binding site; other site
1195464003134	tetramer interface; other site
1195464003135	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1195464003136	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1195464003137	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1195464003138	NAD binding site [chemical binding]; other site
1195464003139	substrate binding site [chemical binding]; other site
1195464003140	homodimer interface [polypeptide binding]; other site
1195464003141	active site
1195464003142	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1195464003143	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1195464003144	NADP binding site [chemical binding]; other site
1195464003145	active site
1195464003146	putative substrate binding site [chemical binding]; other site
1195464003147	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1195464003148	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1195464003149	NAD binding site [chemical binding]; other site
1195464003150	homotetramer interface [polypeptide binding]; other site
1195464003151	homodimer interface [polypeptide binding]; other site
1195464003152	substrate binding site [chemical binding]; other site
1195464003153	active site
1195464003154	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
1195464003155	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
1195464003156	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
1195464003157	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1195464003158	Part of AAA domain; Region: AAA_19; pfam13245
1195464003159	Family description; Region: UvrD_C_2; pfam13538
1195464003160	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464003161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464003162	Coenzyme A binding pocket [chemical binding]; other site
1195464003163	hypothetical protein; Provisional; Region: PRK13679
1195464003164	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1195464003165	Putative esterase; Region: Esterase; pfam00756
1195464003166	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1195464003167	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464003168	EamA-like transporter family; Region: EamA; pfam00892
1195464003169	EamA-like transporter family; Region: EamA; pfam00892
1195464003170	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1195464003171	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1195464003172	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1195464003173	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1195464003174	Na binding site [ion binding]; other site
1195464003175	anthranilate synthase component I; Provisional; Region: PRK13570
1195464003176	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1195464003177	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1195464003178	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1195464003179	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1195464003180	glutamine binding [chemical binding]; other site
1195464003181	catalytic triad [active]
1195464003182	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1195464003183	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1195464003184	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1195464003185	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1195464003186	active site
1195464003187	ribulose/triose binding site [chemical binding]; other site
1195464003188	phosphate binding site [ion binding]; other site
1195464003189	substrate (anthranilate) binding pocket [chemical binding]; other site
1195464003190	product (indole) binding pocket [chemical binding]; other site
1195464003191	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1195464003192	active site
1195464003193	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1195464003194	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1195464003195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464003196	catalytic residue [active]
1195464003197	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1195464003198	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1195464003199	substrate binding site [chemical binding]; other site
1195464003200	active site
1195464003201	catalytic residues [active]
1195464003202	heterodimer interface [polypeptide binding]; other site
1195464003203	Protein of unknown function (DUF4029); Region: DUF4029; pfam13221
1195464003204	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1195464003205	L-lactate permease; Region: Lactate_perm; cl00701
1195464003206	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
1195464003207	RHS protein; Region: RHS; pfam03527
1195464003208	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1195464003209	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464003210	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464003211	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464003212	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1195464003213	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1195464003214	Double zinc ribbon; Region: DZR; pfam12773
1195464003215	Predicted membrane protein [Function unknown]; Region: COG4640
1195464003216	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1195464003217	YARHG domain; Region: YARHG; pfam13308
1195464003218	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1195464003219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464003220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464003221	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1195464003222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464003223	Coenzyme A binding pocket [chemical binding]; other site
1195464003224	Protein of unknown function (DUF3908); Region: DUF3908; pfam13048
1195464003225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464003226	S-adenosylmethionine binding site [chemical binding]; other site
1195464003227	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1195464003228	NADPH bind site [chemical binding]; other site
1195464003229	putative FMN binding site [chemical binding]; other site
1195464003230	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1195464003231	putative FMN binding site [chemical binding]; other site
1195464003232	NADPH bind site [chemical binding]; other site
1195464003233	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1195464003234	YcaO-like family; Region: YcaO; pfam02624
1195464003235	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1195464003236	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
1195464003237	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1195464003238	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1195464003239	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1195464003240	E3 interaction surface; other site
1195464003241	lipoyl attachment site [posttranslational modification]; other site
1195464003242	e3 binding domain; Region: E3_binding; pfam02817
1195464003243	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1195464003244	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1195464003245	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1195464003246	TPP-binding site [chemical binding]; other site
1195464003247	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1195464003248	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464003249	salt bridge; other site
1195464003250	non-specific DNA binding site [nucleotide binding]; other site
1195464003251	sequence-specific DNA binding site [nucleotide binding]; other site
1195464003252	Domain of unknown function (DUF3976); Region: DUF3976; pfam13121
1195464003253	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1195464003254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464003255	Walker A/P-loop; other site
1195464003256	ATP binding site [chemical binding]; other site
1195464003257	Q-loop/lid; other site
1195464003258	ABC transporter signature motif; other site
1195464003259	Walker B; other site
1195464003260	D-loop; other site
1195464003261	H-loop/switch region; other site
1195464003262	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1195464003263	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1195464003264	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1195464003265	SIR2-like domain; Region: SIR2_2; pfam13289
1195464003266	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464003267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464003268	non-specific DNA binding site [nucleotide binding]; other site
1195464003269	salt bridge; other site
1195464003270	sequence-specific DNA binding site [nucleotide binding]; other site
1195464003271	Replication initiation factor; Region: Rep_trans; pfam02486
1195464003272	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464003273	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1195464003274	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1195464003275	Int/Topo IB signature motif; other site
1195464003276	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
1195464003277	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464003278	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1195464003279	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1195464003280	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
1195464003281	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464003282	Catalytic site [active]
1195464003283	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1195464003284	Domain of unknown function (DUF4047); Region: DUF4047; pfam13256
1195464003285	Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389
1195464003286	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464003287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464003288	non-specific DNA binding site [nucleotide binding]; other site
1195464003289	salt bridge; other site
1195464003290	sequence-specific DNA binding site [nucleotide binding]; other site
1195464003291	Anti-repressor SinI; Region: SinI; pfam08671
1195464003292	Anti-repressor SinI; Region: SinI; pfam08671
1195464003293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1195464003294	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
1195464003295	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1195464003296	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1195464003297	NAD(P) binding site [chemical binding]; other site
1195464003298	catalytic residues [active]
1195464003299	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1195464003300	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1195464003301	Walker A/P-loop; other site
1195464003302	ATP binding site [chemical binding]; other site
1195464003303	Q-loop/lid; other site
1195464003304	ABC transporter signature motif; other site
1195464003305	Walker B; other site
1195464003306	D-loop; other site
1195464003307	H-loop/switch region; other site
1195464003308	TOBE domain; Region: TOBE_2; pfam08402
1195464003309	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1195464003310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464003311	dimer interface [polypeptide binding]; other site
1195464003312	conserved gate region; other site
1195464003313	putative PBP binding loops; other site
1195464003314	ABC-ATPase subunit interface; other site
1195464003315	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1195464003316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464003317	dimer interface [polypeptide binding]; other site
1195464003318	conserved gate region; other site
1195464003319	putative PBP binding loops; other site
1195464003320	ABC-ATPase subunit interface; other site
1195464003321	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1195464003322	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1195464003323	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1195464003324	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1195464003325	active site
1195464003326	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1195464003327	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1195464003328	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1195464003329	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1195464003330	active site
1195464003331	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1195464003332	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1195464003333	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1195464003334	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1195464003335	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1195464003336	Cysteine-rich domain; Region: CCG; pfam02754
1195464003337	Cysteine-rich domain; Region: CCG; pfam02754
1195464003338	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464003339	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1195464003340	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1195464003341	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1195464003342	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1195464003343	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1195464003344	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464003345	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464003346	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464003347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464003348	active site
1195464003349	phosphorylation site [posttranslational modification]
1195464003350	intermolecular recognition site; other site
1195464003351	dimerization interface [polypeptide binding]; other site
1195464003352	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464003353	DNA binding site [nucleotide binding]
1195464003354	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1195464003355	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464003356	dimerization interface [polypeptide binding]; other site
1195464003357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464003358	dimer interface [polypeptide binding]; other site
1195464003359	phosphorylation site [posttranslational modification]
1195464003360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003361	ATP binding site [chemical binding]; other site
1195464003362	Mg2+ binding site [ion binding]; other site
1195464003363	G-X-G motif; other site
1195464003364	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1195464003365	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464003366	DNA-binding site [nucleotide binding]; DNA binding site
1195464003367	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1195464003368	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1195464003369	Cysteine-rich domain; Region: CCG; pfam02754
1195464003370	Cysteine-rich domain; Region: CCG; pfam02754
1195464003371	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1195464003372	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1195464003373	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1195464003374	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1195464003375	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1195464003376	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1195464003377	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1195464003378	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1195464003379	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1195464003380	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1195464003381	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1195464003382	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1195464003383	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1195464003384	dimer interaction site [polypeptide binding]; other site
1195464003385	substrate-binding tunnel; other site
1195464003386	active site
1195464003387	catalytic site [active]
1195464003388	substrate binding site [chemical binding]; other site
1195464003389	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
1195464003390	poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719
1195464003391	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464003392	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
1195464003393	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
1195464003394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464003395	NAD(P) binding site [chemical binding]; other site
1195464003396	active site
1195464003397	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
1195464003398	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1195464003399	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1195464003400	FAD dependent oxidoreductase; Region: DAO; pfam01266
1195464003401	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464003402	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1195464003403	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1195464003404	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
1195464003405	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1195464003406	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1195464003407	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1195464003408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464003409	Walker A/P-loop; other site
1195464003410	ATP binding site [chemical binding]; other site
1195464003411	Q-loop/lid; other site
1195464003412	ABC transporter signature motif; other site
1195464003413	Walker B; other site
1195464003414	D-loop; other site
1195464003415	H-loop/switch region; other site
1195464003416	TOBE domain; Region: TOBE_2; pfam08402
1195464003417	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1195464003418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464003419	dimer interface [polypeptide binding]; other site
1195464003420	conserved gate region; other site
1195464003421	putative PBP binding loops; other site
1195464003422	ABC-ATPase subunit interface; other site
1195464003423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464003424	dimer interface [polypeptide binding]; other site
1195464003425	conserved gate region; other site
1195464003426	putative PBP binding loops; other site
1195464003427	ABC-ATPase subunit interface; other site
1195464003428	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1195464003429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464003430	motif II; other site
1195464003431	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1195464003432	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464003433	catalytic residue [active]
1195464003434	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1195464003435	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1195464003436	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1195464003437	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1195464003438	hypothetical protein; Validated; Region: PRK06755
1195464003439	intersubunit interface [polypeptide binding]; other site
1195464003440	active site
1195464003441	Zn2+ binding site [ion binding]; other site
1195464003442	FOG: CBS domain [General function prediction only]; Region: COG0517
1195464003443	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1195464003444	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1195464003445	NodB motif; other site
1195464003446	putative active site [active]
1195464003447	putative catalytic site [active]
1195464003448	Zn binding site [ion binding]; other site
1195464003449	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1195464003450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464003451	dimer interface [polypeptide binding]; other site
1195464003452	phosphorylation site [posttranslational modification]
1195464003453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003454	ATP binding site [chemical binding]; other site
1195464003455	Mg2+ binding site [ion binding]; other site
1195464003456	G-X-G motif; other site
1195464003457	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464003458	MarR family; Region: MarR; pfam01047
1195464003459	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
1195464003460	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
1195464003461	active site
1195464003462	Zn binding site [ion binding]; other site
1195464003463	DinB superfamily; Region: DinB_2; pfam12867
1195464003464	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1195464003465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464003466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464003467	dimer interface [polypeptide binding]; other site
1195464003468	phosphorylation site [posttranslational modification]
1195464003469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003470	ATP binding site [chemical binding]; other site
1195464003471	Mg2+ binding site [ion binding]; other site
1195464003472	G-X-G motif; other site
1195464003473	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1195464003474	Ligand Binding Site [chemical binding]; other site
1195464003475	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1195464003476	active site
1195464003477	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1195464003478	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464003479	FeS/SAM binding site; other site
1195464003480	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1195464003481	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953
1195464003482	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1195464003483	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464003484	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464003485	Coenzyme A binding pocket [chemical binding]; other site
1195464003486	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1195464003487	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1195464003488	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1195464003489	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
1195464003490	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1195464003491	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1195464003492	dimer interface [polypeptide binding]; other site
1195464003493	putative radical transfer pathway; other site
1195464003494	diiron center [ion binding]; other site
1195464003495	tyrosyl radical; other site
1195464003496	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1195464003497	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1195464003498	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1195464003499	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1195464003500	NAD(P) binding site [chemical binding]; other site
1195464003501	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1195464003502	hypothetical protein; Validated; Region: PRK06748; cl17661
1195464003503	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1195464003504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464003505	putative active site [active]
1195464003506	heme pocket [chemical binding]; other site
1195464003507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464003508	Walker A motif; other site
1195464003509	ATP binding site [chemical binding]; other site
1195464003510	Walker B motif; other site
1195464003511	arginine finger; other site
1195464003512	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1195464003513	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1195464003514	tetramerization interface [polypeptide binding]; other site
1195464003515	NAD(P) binding site [chemical binding]; other site
1195464003516	catalytic residues [active]
1195464003517	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
1195464003518	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464003519	inhibitor-cofactor binding pocket; inhibition site
1195464003520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464003521	catalytic residue [active]
1195464003522	Predicted transcriptional regulators [Transcription]; Region: COG1725
1195464003523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464003524	DNA-binding site [nucleotide binding]; DNA binding site
1195464003525	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1195464003526	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464003527	Walker A/P-loop; other site
1195464003528	ATP binding site [chemical binding]; other site
1195464003529	Q-loop/lid; other site
1195464003530	ABC transporter signature motif; other site
1195464003531	Walker B; other site
1195464003532	D-loop; other site
1195464003533	H-loop/switch region; other site
1195464003534	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464003535	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464003536	Walker A/P-loop; other site
1195464003537	ATP binding site [chemical binding]; other site
1195464003538	Q-loop/lid; other site
1195464003539	ABC transporter signature motif; other site
1195464003540	Walker B; other site
1195464003541	D-loop; other site
1195464003542	H-loop/switch region; other site
1195464003543	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1195464003544	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1195464003545	CAAX protease self-immunity; Region: Abi; pfam02517
1195464003546	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464003547	Protein of unknown function (DUF3913); Region: DUF3913; pfam13052
1195464003548	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1195464003549	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464003550	putative DNA binding site [nucleotide binding]; other site
1195464003551	putative Zn2+ binding site [ion binding]; other site
1195464003552	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464003553	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1195464003554	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464003555	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1195464003556	catalytic triad [active]
1195464003557	conserved cis-peptide bond; other site
1195464003558	SseB protein; Region: SseB; cl06279
1195464003559	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1195464003560	dimer interface [polypeptide binding]; other site
1195464003561	catalytic triad [active]
1195464003562	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1195464003563	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1195464003564	FMN binding site [chemical binding]; other site
1195464003565	substrate binding site [chemical binding]; other site
1195464003566	putative catalytic residue [active]
1195464003567	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1195464003568	DltD N-terminal region; Region: DltD_N; pfam04915
1195464003569	DltD central region; Region: DltD_M; pfam04918
1195464003570	DltD C-terminal region; Region: DltD_C; pfam04914
1195464003571	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1195464003572	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1195464003573	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1195464003574	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1195464003575	acyl-activating enzyme (AAE) consensus motif; other site
1195464003576	AMP binding site [chemical binding]; other site
1195464003577	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1195464003578	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464003579	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1195464003580	metal binding site [ion binding]; metal-binding site
1195464003581	dimer interface [polypeptide binding]; other site
1195464003582	flavodoxin; Provisional; Region: PRK06756
1195464003583	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1195464003584	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464003585	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464003586	active site
1195464003587	substrate binding site [chemical binding]; other site
1195464003588	ATP binding site [chemical binding]; other site
1195464003589	multidrug efflux protein; Reviewed; Region: PRK01766
1195464003590	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1195464003591	cation binding site [ion binding]; other site
1195464003592	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1195464003593	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1195464003594	hydrophobic ligand binding site; other site
1195464003595	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464003596	catalytic residues [active]
1195464003597	Regulatory protein YrvL; Region: YrvL; pfam14184
1195464003598	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464003599	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1195464003600	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1195464003601	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1195464003602	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1195464003603	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1195464003604	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1195464003605	hypothetical protein; Provisional; Region: PRK03094
1195464003606	Protein of unknown function (DUF3911); Region: DUF3911; pfam13050
1195464003607	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1195464003608	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1195464003609	homodimer interface [polypeptide binding]; other site
1195464003610	substrate-cofactor binding pocket; other site
1195464003611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464003612	catalytic residue [active]
1195464003613	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
1195464003614	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1195464003615	PYR/PP interface [polypeptide binding]; other site
1195464003616	dimer interface [polypeptide binding]; other site
1195464003617	TPP binding site [chemical binding]; other site
1195464003618	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1195464003619	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1195464003620	TPP-binding site [chemical binding]; other site
1195464003621	dimer interface [polypeptide binding]; other site
1195464003622	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1195464003623	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1195464003624	putative valine binding site [chemical binding]; other site
1195464003625	dimer interface [polypeptide binding]; other site
1195464003626	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1195464003627	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1195464003628	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1195464003629	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1195464003630	2-isopropylmalate synthase; Validated; Region: PRK00915
1195464003631	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1195464003632	active site
1195464003633	catalytic residues [active]
1195464003634	metal binding site [ion binding]; metal-binding site
1195464003635	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1195464003636	tartrate dehydrogenase; Region: TTC; TIGR02089
1195464003637	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1195464003638	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1195464003639	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1195464003640	substrate binding site [chemical binding]; other site
1195464003641	ligand binding site [chemical binding]; other site
1195464003642	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1195464003643	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1195464003644	substrate binding site [chemical binding]; other site
1195464003645	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
1195464003646	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1195464003647	dimer interface [polypeptide binding]; other site
1195464003648	motif 1; other site
1195464003649	active site
1195464003650	motif 2; other site
1195464003651	motif 3; other site
1195464003652	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1195464003653	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1195464003654	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1195464003655	histidinol dehydrogenase; Region: hisD; TIGR00069
1195464003656	NAD binding site [chemical binding]; other site
1195464003657	dimerization interface [polypeptide binding]; other site
1195464003658	product binding site; other site
1195464003659	substrate binding site [chemical binding]; other site
1195464003660	zinc binding site [ion binding]; other site
1195464003661	catalytic residues [active]
1195464003662	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1195464003663	putative active site pocket [active]
1195464003664	4-fold oligomerization interface [polypeptide binding]; other site
1195464003665	metal binding residues [ion binding]; metal-binding site
1195464003666	3-fold/trimer interface [polypeptide binding]; other site
1195464003667	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1195464003668	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1195464003669	putative active site [active]
1195464003670	oxyanion strand; other site
1195464003671	catalytic triad [active]
1195464003672	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1195464003673	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1195464003674	catalytic residues [active]
1195464003675	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1195464003676	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1195464003677	substrate binding site [chemical binding]; other site
1195464003678	glutamase interaction surface [polypeptide binding]; other site
1195464003679	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1195464003680	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1195464003681	metal binding site [ion binding]; metal-binding site
1195464003682	histidinol-phosphatase; Validated; Region: PRK06740
1195464003683	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1195464003684	dimer interface [polypeptide binding]; other site
1195464003685	active site
1195464003686	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1195464003687	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1195464003688	putative ligand binding site [chemical binding]; other site
1195464003689	putative NAD binding site [chemical binding]; other site
1195464003690	catalytic site [active]
1195464003691	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1195464003692	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1195464003693	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1195464003694	Sulfatase; Region: Sulfatase; pfam00884
1195464003695	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
1195464003696	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1195464003697	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1195464003698	active site
1195464003699	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1195464003700	substrate binding site [chemical binding]; other site
1195464003701	catalytic residues [active]
1195464003702	dimer interface [polypeptide binding]; other site
1195464003703	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
1195464003704	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1195464003705	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1195464003706	Active Sites [active]
1195464003707	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1195464003708	ATP-sulfurylase; Region: ATPS; cd00517
1195464003709	active site
1195464003710	HXXH motif; other site
1195464003711	flexible loop; other site
1195464003712	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1195464003713	ligand-binding site [chemical binding]; other site
1195464003714	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
1195464003715	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1195464003716	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1195464003717	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
1195464003718	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1195464003719	diphthine synthase; Region: dph5; TIGR00522
1195464003720	active site
1195464003721	SAM binding site [chemical binding]; other site
1195464003722	homodimer interface [polypeptide binding]; other site
1195464003723	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1195464003724	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1195464003725	putative active site [active]
1195464003726	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1195464003727	putative active site [active]
1195464003728	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
1195464003729	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1195464003730	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1195464003731	Na2 binding site [ion binding]; other site
1195464003732	putative substrate binding site 1 [chemical binding]; other site
1195464003733	Na binding site 1 [ion binding]; other site
1195464003734	putative substrate binding site 2 [chemical binding]; other site
1195464003735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1195464003736	TMPIT-like protein; Region: TMPIT; pfam07851
1195464003737	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464003738	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464003739	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1195464003740	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1195464003741	Protein of unknown function (DUF402); Region: DUF402; cl00979
1195464003742	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1195464003743	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1195464003744	Vpu protein; Region: Vpu; pfam00558
1195464003745	PspA/IM30 family; Region: PspA_IM30; pfam04012
1195464003746	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1195464003747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464003748	Histidine kinase; Region: HisKA_3; pfam07730
1195464003749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003750	ATP binding site [chemical binding]; other site
1195464003751	Mg2+ binding site [ion binding]; other site
1195464003752	G-X-G motif; other site
1195464003753	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464003754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464003755	active site
1195464003756	phosphorylation site [posttranslational modification]
1195464003757	intermolecular recognition site; other site
1195464003758	dimerization interface [polypeptide binding]; other site
1195464003759	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464003760	DNA binding residues [nucleotide binding]
1195464003761	dimerization interface [polypeptide binding]; other site
1195464003762	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1195464003763	E3 interaction surface; other site
1195464003764	lipoyl attachment site [posttranslational modification]; other site
1195464003765	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464003766	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464003767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464003768	S-adenosylmethionine binding site [chemical binding]; other site
1195464003769	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1195464003770	Peptidase family M50; Region: Peptidase_M50; pfam02163
1195464003771	active site
1195464003772	putative substrate binding region [chemical binding]; other site
1195464003773	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1195464003774	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1195464003775	heme-binding site [chemical binding]; other site
1195464003776	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1195464003777	FAD binding pocket [chemical binding]; other site
1195464003778	FAD binding motif [chemical binding]; other site
1195464003779	phosphate binding motif [ion binding]; other site
1195464003780	beta-alpha-beta structure motif; other site
1195464003781	NAD binding pocket [chemical binding]; other site
1195464003782	Heme binding  pocket [chemical binding]; other site
1195464003783	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1195464003784	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464003785	ligand binding site [chemical binding]; other site
1195464003786	flexible hinge region; other site
1195464003787	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1195464003788	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464003789	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1195464003790	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1195464003791	Transglycosylase; Region: Transgly; pfam00912
1195464003792	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1195464003793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464003794	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1195464003795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464003796	putative active site [active]
1195464003797	heme pocket [chemical binding]; other site
1195464003798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464003799	dimer interface [polypeptide binding]; other site
1195464003800	phosphorylation site [posttranslational modification]
1195464003801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003802	ATP binding site [chemical binding]; other site
1195464003803	Mg2+ binding site [ion binding]; other site
1195464003804	G-X-G motif; other site
1195464003805	Protein of unknown function DUF72; Region: DUF72; pfam01904
1195464003806	Protein of unknown function (DUF3924); Region: DUF3924; pfam13062
1195464003807	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464003808	active site
1195464003809	DNA binding site [nucleotide binding]
1195464003810	Int/Topo IB signature motif; other site
1195464003811	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464003812	dimerization interface [polypeptide binding]; other site
1195464003813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464003814	dimer interface [polypeptide binding]; other site
1195464003815	phosphorylation site [posttranslational modification]
1195464003816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003817	ATP binding site [chemical binding]; other site
1195464003818	Mg2+ binding site [ion binding]; other site
1195464003819	G-X-G motif; other site
1195464003820	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1195464003821	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1195464003822	Predicted integral membrane protein [Function unknown]; Region: COG0392
1195464003823	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1195464003824	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1195464003825	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
1195464003826	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1195464003827	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1195464003828	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1195464003829	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464003830	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1195464003831	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1195464003832	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1195464003833	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1195464003834	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464003835	RNA binding surface [nucleotide binding]; other site
1195464003836	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1195464003837	active site
1195464003838	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1195464003839	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1195464003840	catalytic residues [active]
1195464003841	Double zinc ribbon; Region: DZR; pfam12773
1195464003842	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1195464003843	ResB-like family; Region: ResB; pfam05140
1195464003844	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1195464003845	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1195464003846	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464003847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464003848	active site
1195464003849	phosphorylation site [posttranslational modification]
1195464003850	intermolecular recognition site; other site
1195464003851	dimerization interface [polypeptide binding]; other site
1195464003852	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464003853	DNA binding site [nucleotide binding]
1195464003854	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1195464003855	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464003856	dimerization interface [polypeptide binding]; other site
1195464003857	PAS domain; Region: PAS; smart00091
1195464003858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464003859	dimer interface [polypeptide binding]; other site
1195464003860	phosphorylation site [posttranslational modification]
1195464003861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464003862	ATP binding site [chemical binding]; other site
1195464003863	Mg2+ binding site [ion binding]; other site
1195464003864	G-X-G motif; other site
1195464003865	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1195464003866	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464003867	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464003868	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1195464003869	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464003870	Predicted membrane protein [Function unknown]; Region: COG3601
1195464003871	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1195464003872	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1195464003873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1195464003874	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1195464003875	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464003876	ATP binding site [chemical binding]; other site
1195464003877	putative Mg++ binding site [ion binding]; other site
1195464003878	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464003879	nucleotide binding region [chemical binding]; other site
1195464003880	ATP-binding site [chemical binding]; other site
1195464003881	CAAX protease self-immunity; Region: Abi; pfam02517
1195464003882	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464003883	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1195464003884	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464003885	putative active site [active]
1195464003886	putative metal binding site [ion binding]; other site
1195464003887	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464003888	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1195464003889	DNA binding residues [nucleotide binding]
1195464003890	B12 binding domain; Region: B12-binding_2; pfam02607
1195464003891	adaptor protein; Provisional; Region: PRK02899
1195464003892	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1195464003893	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1195464003894	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1195464003895	NAD(P) binding site [chemical binding]; other site
1195464003896	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
1195464003897	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464003898	amidase catalytic site [active]
1195464003899	Zn binding residues [ion binding]; other site
1195464003900	substrate binding site [chemical binding]; other site
1195464003901	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1195464003902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1195464003903	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464003904	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1195464003905	active site
1195464003906	homotetramer interface [polypeptide binding]; other site
1195464003907	homodimer interface [polypeptide binding]; other site
1195464003908	cytidylate kinase; Provisional; Region: cmk; PRK00023
1195464003909	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1195464003910	CMP-binding site; other site
1195464003911	The sites determining sugar specificity; other site
1195464003912	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1195464003913	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1195464003914	RNA binding site [nucleotide binding]; other site
1195464003915	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1195464003916	RNA binding site [nucleotide binding]; other site
1195464003917	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1195464003918	RNA binding site [nucleotide binding]; other site
1195464003919	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1195464003920	RNA binding site [nucleotide binding]; other site
1195464003921	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1195464003922	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1195464003923	homotetramer interface [polypeptide binding]; other site
1195464003924	FMN binding site [chemical binding]; other site
1195464003925	homodimer contacts [polypeptide binding]; other site
1195464003926	putative active site [active]
1195464003927	putative substrate binding site [chemical binding]; other site
1195464003928	YpzI-like protein; Region: YpzI; pfam14140
1195464003929	YIEGIA protein; Region: YIEGIA; pfam14045
1195464003930	GTP-binding protein Der; Reviewed; Region: PRK00093
1195464003931	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1195464003932	G1 box; other site
1195464003933	GTP/Mg2+ binding site [chemical binding]; other site
1195464003934	Switch I region; other site
1195464003935	G2 box; other site
1195464003936	Switch II region; other site
1195464003937	G3 box; other site
1195464003938	G4 box; other site
1195464003939	G5 box; other site
1195464003940	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1195464003941	G1 box; other site
1195464003942	GTP/Mg2+ binding site [chemical binding]; other site
1195464003943	Switch I region; other site
1195464003944	G2 box; other site
1195464003945	G3 box; other site
1195464003946	Switch II region; other site
1195464003947	G4 box; other site
1195464003948	G5 box; other site
1195464003949	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1195464003950	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1195464003951	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1195464003952	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1195464003953	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
1195464003954	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
1195464003955	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1195464003956	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1195464003957	IHF dimer interface [polypeptide binding]; other site
1195464003958	IHF - DNA interface [nucleotide binding]; other site
1195464003959	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1195464003960	homodecamer interface [polypeptide binding]; other site
1195464003961	GTP cyclohydrolase I; Provisional; Region: PLN03044
1195464003962	active site
1195464003963	putative catalytic site residues [active]
1195464003964	zinc binding site [ion binding]; other site
1195464003965	GTP-CH-I/GFRP interaction surface; other site
1195464003966	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1195464003967	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1195464003968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464003969	S-adenosylmethionine binding site [chemical binding]; other site
1195464003970	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1195464003971	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1195464003972	substrate binding pocket [chemical binding]; other site
1195464003973	chain length determination region; other site
1195464003974	substrate-Mg2+ binding site; other site
1195464003975	catalytic residues [active]
1195464003976	aspartate-rich region 1; other site
1195464003977	active site lid residues [active]
1195464003978	aspartate-rich region 2; other site
1195464003979	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1195464003980	active site
1195464003981	multimer interface [polypeptide binding]; other site
1195464003982	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1195464003983	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1195464003984	Tetramer interface [polypeptide binding]; other site
1195464003985	active site
1195464003986	FMN-binding site [chemical binding]; other site
1195464003987	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1195464003988	active site
1195464003989	dimer interface [polypeptide binding]; other site
1195464003990	metal binding site [ion binding]; metal-binding site
1195464003991	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1195464003992	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464003993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464003994	homodimer interface [polypeptide binding]; other site
1195464003995	catalytic residue [active]
1195464003996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464003997	TPR motif; other site
1195464003998	binding surface
1195464003999	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464004000	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464004001	binding surface
1195464004002	TPR motif; other site
1195464004003	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1195464004004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464004005	binding surface
1195464004006	TPR motif; other site
1195464004007	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1195464004008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464004009	binding surface
1195464004010	TPR motif; other site
1195464004011	hypothetical protein; Provisional; Region: PRK03636
1195464004012	UPF0302 domain; Region: UPF0302; pfam08864
1195464004013	IDEAL domain; Region: IDEAL; pfam08858
1195464004014	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
1195464004015	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1195464004016	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1195464004017	iron-sulfur cluster [ion binding]; other site
1195464004018	[2Fe-2S] cluster binding site [ion binding]; other site
1195464004019	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1195464004020	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1195464004021	interchain domain interface [polypeptide binding]; other site
1195464004022	intrachain domain interface; other site
1195464004023	heme bH binding site [chemical binding]; other site
1195464004024	Qi binding site; other site
1195464004025	heme bL binding site [chemical binding]; other site
1195464004026	Qo binding site; other site
1195464004027	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1195464004028	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1195464004029	interchain domain interface [polypeptide binding]; other site
1195464004030	intrachain domain interface; other site
1195464004031	Qi binding site; other site
1195464004032	Qo binding site; other site
1195464004033	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1195464004034	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1195464004035	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
1195464004036	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
1195464004037	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800
1195464004038	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
1195464004039	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1195464004040	active site
1195464004041	Fe-S cluster binding site [ion binding]; other site
1195464004042	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464004043	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464004044	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464004045	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464004046	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1195464004047	homodimer interface [polypeptide binding]; other site
1195464004048	metal binding site [ion binding]; metal-binding site
1195464004049	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1195464004050	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1195464004051	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1195464004052	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1195464004053	active site
1195464004054	dimer interfaces [polypeptide binding]; other site
1195464004055	catalytic residues [active]
1195464004056	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1195464004057	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1195464004058	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1195464004059	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1195464004060	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1195464004061	active site
1195464004062	NTP binding site [chemical binding]; other site
1195464004063	metal binding triad [ion binding]; metal-binding site
1195464004064	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1195464004065	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1195464004066	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1195464004067	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1195464004068	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1195464004069	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1195464004070	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1195464004071	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1195464004072	oligomerization interface [polypeptide binding]; other site
1195464004073	active site
1195464004074	metal binding site [ion binding]; metal-binding site
1195464004075	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1195464004076	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1195464004077	active site
1195464004078	ATP-binding site [chemical binding]; other site
1195464004079	pantoate-binding site; other site
1195464004080	HXXH motif; other site
1195464004081	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1195464004082	tetramerization interface [polypeptide binding]; other site
1195464004083	active site
1195464004084	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1195464004085	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1195464004086	active site
1195464004087	catalytic site [active]
1195464004088	substrate binding site [chemical binding]; other site
1195464004089	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1195464004090	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464004091	putative Mg++ binding site [ion binding]; other site
1195464004092	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1195464004093	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
1195464004094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1195464004095	aspartate aminotransferase; Provisional; Region: PRK05764
1195464004096	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464004097	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464004098	homodimer interface [polypeptide binding]; other site
1195464004099	catalytic residue [active]
1195464004100	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1195464004101	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1195464004102	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1195464004103	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1195464004104	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1195464004105	minor groove reading motif; other site
1195464004106	helix-hairpin-helix signature motif; other site
1195464004107	substrate binding pocket [chemical binding]; other site
1195464004108	active site
1195464004109	Transglycosylase; Region: Transgly; pfam00912
1195464004110	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1195464004111	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464004112	Fibronectin type III domain; Region: fn3; pfam00041
1195464004113	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1195464004114	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1195464004115	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
1195464004116	YppF-like protein; Region: YppF; pfam14178
1195464004117	YppG-like protein; Region: YppG; pfam14179
1195464004118	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
1195464004119	hypothetical protein; Provisional; Region: PRK13660
1195464004120	cell division protein GpsB; Provisional; Region: PRK14127
1195464004121	DivIVA domain; Region: DivI1A_domain; TIGR03544
1195464004122	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1195464004123	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1195464004124	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1195464004125	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464004126	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1195464004127	active site
1195464004128	DNA binding site [nucleotide binding]
1195464004129	Int/Topo IB signature motif; other site
1195464004130	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
1195464004131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464004132	sequence-specific DNA binding site [nucleotide binding]; other site
1195464004133	salt bridge; other site
1195464004134	Helix-turn-helix domain; Region: HTH_36; pfam13730
1195464004135	large terminase protein; Provisional; Region: 17; PHA02533
1195464004136	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1195464004137	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
1195464004138	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1195464004139	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1195464004140	Protein of unknown function (DUF3921); Region: DUF3921; pfam13060
1195464004141	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1195464004142	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1195464004143	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1195464004144	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1195464004145	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1195464004146	active site
1195464004147	Zn binding site [ion binding]; other site
1195464004148	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464004149	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464004150	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464004151	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464004152	substrate binding site [chemical binding]; other site
1195464004153	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1195464004154	active site
1195464004155	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464004156	active site
1195464004157	xanthine permease; Region: pbuX; TIGR03173
1195464004158	Predicted membrane protein [Function unknown]; Region: COG2311
1195464004159	Protein of unknown function (DUF418); Region: DUF418; cl12135
1195464004160	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1195464004161	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1195464004162	Dynamin family; Region: Dynamin_N; pfam00350
1195464004163	G1 box; other site
1195464004164	GTP/Mg2+ binding site [chemical binding]; other site
1195464004165	G2 box; other site
1195464004166	Switch I region; other site
1195464004167	G3 box; other site
1195464004168	Switch II region; other site
1195464004169	G4 box; other site
1195464004170	G5 box; other site
1195464004171	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1195464004172	Dynamin family; Region: Dynamin_N; pfam00350
1195464004173	G1 box; other site
1195464004174	GTP/Mg2+ binding site [chemical binding]; other site
1195464004175	G2 box; other site
1195464004176	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1195464004177	G3 box; other site
1195464004178	Switch II region; other site
1195464004179	GTP/Mg2+ binding site [chemical binding]; other site
1195464004180	G4 box; other site
1195464004181	G5 box; other site
1195464004182	Protein of unknown function (DUF3931); Region: DUF3931; pfam13082
1195464004183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464004184	Coenzyme A binding pocket [chemical binding]; other site
1195464004185	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
1195464004186	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1195464004187	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1195464004188	active site residue [active]
1195464004189	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1195464004190	active site residue [active]
1195464004191	Probable transposase; Region: OrfB_IS605; pfam01385
1195464004192	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1195464004193	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1195464004194	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1195464004195	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1195464004196	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1195464004197	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1195464004198	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464004199	5'-3' exonuclease; Region: 53EXOc; smart00475
1195464004200	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1195464004201	active site
1195464004202	metal binding site 1 [ion binding]; metal-binding site
1195464004203	putative 5' ssDNA interaction site; other site
1195464004204	metal binding site 3; metal-binding site
1195464004205	metal binding site 2 [ion binding]; metal-binding site
1195464004206	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1195464004207	putative DNA binding site [nucleotide binding]; other site
1195464004208	putative metal binding site [ion binding]; other site
1195464004209	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1195464004210	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004211	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004212	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004213	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004214	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004215	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004216	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004217	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004218	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004219	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004220	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004221	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004222	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004223	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004224	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004225	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004226	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004227	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004228	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004229	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004230	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004231	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004232	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004233	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004234	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004235	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004236	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004237	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004238	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464004239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464004240	Coenzyme A binding pocket [chemical binding]; other site
1195464004241	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1195464004242	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464004243	catalytic triad [active]
1195464004244	conserved cis-peptide bond; other site
1195464004245	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464004246	EamA-like transporter family; Region: EamA; pfam00892
1195464004247	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1195464004248	RNA/DNA hybrid binding site [nucleotide binding]; other site
1195464004249	active site
1195464004250	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1195464004251	active site
1195464004252	catalytic residues [active]
1195464004253	QueT transporter; Region: QueT; pfam06177
1195464004254	hypothetical protein; Validated; Region: PRK07708
1195464004255	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1195464004256	RNA/DNA hybrid binding site [nucleotide binding]; other site
1195464004257	active site
1195464004258	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1195464004259	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
1195464004260	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1195464004261	DNA-binding site [nucleotide binding]; DNA binding site
1195464004262	RNA-binding motif; other site
1195464004263	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
1195464004264	LysE type translocator; Region: LysE; pfam01810
1195464004265	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1195464004266	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1195464004267	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1195464004268	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1195464004269	Na binding site [ion binding]; other site
1195464004270	aminotransferase; Validated; Region: PRK07678
1195464004271	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464004272	inhibitor-cofactor binding pocket; inhibition site
1195464004273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464004274	catalytic residue [active]
1195464004275	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
1195464004276	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1195464004277	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1195464004278	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464004279	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1195464004280	DNA binding residues [nucleotide binding]
1195464004281	drug binding residues [chemical binding]; other site
1195464004282	dimer interface [polypeptide binding]; other site
1195464004283	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
1195464004284	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1195464004285	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
1195464004286	Predicted membrane protein [Function unknown]; Region: COG2323
1195464004287	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1195464004288	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1195464004289	putative active site [active]
1195464004290	Tic20-like protein; Region: Tic20; pfam09685
1195464004291	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1195464004292	dimer interface [polypeptide binding]; other site
1195464004293	FMN binding site [chemical binding]; other site
1195464004294	NADPH bind site [chemical binding]; other site
1195464004295	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1195464004296	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464004297	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464004298	DNA binding residues [nucleotide binding]
1195464004299	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464004300	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464004301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004302	putative substrate translocation pore; other site
1195464004303	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464004304	active site
1195464004305	metal binding site [ion binding]; metal-binding site
1195464004306	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464004307	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1195464004308	bacterial Hfq-like; Region: Hfq; cd01716
1195464004309	hexamer interface [polypeptide binding]; other site
1195464004310	Sm1 motif; other site
1195464004311	RNA binding site [nucleotide binding]; other site
1195464004312	Sm2 motif; other site
1195464004313	HD domain; Region: HD_3; pfam13023
1195464004314	flagellar motor protein MotP; Reviewed; Region: PRK06743
1195464004315	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1195464004316	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1195464004317	ligand binding site [chemical binding]; other site
1195464004318	Response regulator receiver domain; Region: Response_reg; pfam00072
1195464004319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004320	active site
1195464004321	phosphorylation site [posttranslational modification]
1195464004322	intermolecular recognition site; other site
1195464004323	dimerization interface [polypeptide binding]; other site
1195464004324	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1195464004325	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1195464004326	putative binding surface; other site
1195464004327	active site
1195464004328	P2 response regulator binding domain; Region: P2; pfam07194
1195464004329	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1195464004330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464004331	ATP binding site [chemical binding]; other site
1195464004332	Mg2+ binding site [ion binding]; other site
1195464004333	G-X-G motif; other site
1195464004334	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1195464004335	flagellar motor switch protein; Reviewed; Region: PRK06782
1195464004336	CheC-like family; Region: CheC; pfam04509
1195464004337	CheC-like family; Region: CheC; pfam04509
1195464004338	CheC-like family; Region: CheC; pfam04509
1195464004339	CheC-like family; Region: CheC; pfam04509
1195464004340	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1195464004341	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1195464004342	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1195464004343	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1195464004344	Protein of unknown function (DUF327); Region: DUF327; pfam03885
1195464004345	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
1195464004346	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
1195464004347	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
1195464004348	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1195464004349	flagellar capping protein; Validated; Region: fliD; PRK06798
1195464004350	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1195464004351	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1195464004352	Flagellar protein FliS; Region: FliS; cl00654
1195464004353	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
1195464004354	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1195464004355	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1195464004356	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1195464004357	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
1195464004358	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1195464004359	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1195464004360	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1195464004361	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1195464004362	FliG C-terminal domain; Region: FliG_C; pfam01706
1195464004363	flagellar assembly protein H; Validated; Region: fliH; PRK06800
1195464004364	Flagellar assembly protein FliH; Region: FliH; pfam02108
1195464004365	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
1195464004366	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464004367	Walker A motif; other site
1195464004368	ATP binding site [chemical binding]; other site
1195464004369	Walker B motif; other site
1195464004370	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1195464004371	flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792
1195464004372	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1195464004373	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1195464004374	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1195464004375	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1195464004376	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1195464004377	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
1195464004378	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1195464004379	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1195464004380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004381	active site
1195464004382	phosphorylation site [posttranslational modification]
1195464004383	intermolecular recognition site; other site
1195464004384	dimerization interface [polypeptide binding]; other site
1195464004385	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
1195464004386	flagellin; Provisional; Region: PRK12807
1195464004387	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1195464004388	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1195464004389	flagellin; Reviewed; Region: PRK08869
1195464004390	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1195464004391	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1195464004392	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1195464004393	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1195464004394	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1195464004395	catalytic residue [active]
1195464004396	flagellar motor switch protein; Validated; Region: PRK06789
1195464004397	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1195464004398	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1195464004399	flagellar motor switch protein; Validated; Region: PRK06788
1195464004400	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1195464004401	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1195464004402	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1195464004403	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1195464004404	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1195464004405	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1195464004406	FHIPEP family; Region: FHIPEP; pfam00771
1195464004407	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889
1195464004408	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1195464004409	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
1195464004410	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
1195464004411	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1195464004412	Predicted transcriptional regulators [Transcription]; Region: COG1378
1195464004413	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1195464004414	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1195464004415	C-terminal domain interface [polypeptide binding]; other site
1195464004416	sugar binding site [chemical binding]; other site
1195464004417	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1195464004418	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1195464004419	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
1195464004420	Dienelactone hydrolase family; Region: DLH; pfam01738
1195464004421	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1195464004422	small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861
1195464004423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464004424	non-specific DNA binding site [nucleotide binding]; other site
1195464004425	salt bridge; other site
1195464004426	sequence-specific DNA binding site [nucleotide binding]; other site
1195464004427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004428	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464004429	putative substrate translocation pore; other site
1195464004430	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
1195464004431	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464004432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464004433	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464004434	dimerization interface [polypeptide binding]; other site
1195464004435	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1195464004436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464004437	Walker A/P-loop; other site
1195464004438	ATP binding site [chemical binding]; other site
1195464004439	Q-loop/lid; other site
1195464004440	ABC transporter signature motif; other site
1195464004441	Walker B; other site
1195464004442	D-loop; other site
1195464004443	H-loop/switch region; other site
1195464004444	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1195464004445	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1195464004446	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1195464004447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464004448	dimer interface [polypeptide binding]; other site
1195464004449	conserved gate region; other site
1195464004450	putative PBP binding loops; other site
1195464004451	ABC-ATPase subunit interface; other site
1195464004452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464004453	dimer interface [polypeptide binding]; other site
1195464004454	conserved gate region; other site
1195464004455	putative PBP binding loops; other site
1195464004456	ABC-ATPase subunit interface; other site
1195464004457	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1195464004458	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1195464004459	Beta-Casp domain; Region: Beta-Casp; smart01027
1195464004460	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1195464004461	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
1195464004462	Cupin; Region: Cupin_1; smart00835
1195464004463	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1195464004464	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464004465	catalytic core [active]
1195464004466	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464004467	hypothetical protein; Provisional; Region: PRK09272
1195464004468	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464004469	MarR family; Region: MarR; pfam01047
1195464004470	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1195464004471	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1195464004472	active site
1195464004473	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1195464004474	dimer interface [polypeptide binding]; other site
1195464004475	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1195464004476	Ligand Binding Site [chemical binding]; other site
1195464004477	Molecular Tunnel; other site
1195464004478	RNA polymerase factor sigma-70; Validated; Region: PRK06811
1195464004479	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464004480	DNA binding residues [nucleotide binding]
1195464004481	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1195464004482	VPS10 domain; Region: VPS10; smart00602
1195464004483	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1195464004484	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
1195464004485	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1195464004486	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464004487	DNA-binding site [nucleotide binding]; DNA binding site
1195464004488	FCD domain; Region: FCD; pfam07729
1195464004489	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464004490	EamA-like transporter family; Region: EamA; pfam00892
1195464004491	EamA-like transporter family; Region: EamA; pfam00892
1195464004492	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
1195464004493	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1195464004494	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1195464004495	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1195464004496	Predicted permeases [General function prediction only]; Region: COG0701
1195464004497	TIGR03943 family protein; Region: TIGR03943
1195464004498	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1195464004499	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1195464004500	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464004501	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1195464004502	DNA binding residues [nucleotide binding]
1195464004503	putative dimer interface [polypeptide binding]; other site
1195464004504	short chain dehydrogenase; Provisional; Region: PRK06123
1195464004505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464004506	NAD(P) binding site [chemical binding]; other site
1195464004507	active site
1195464004508	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1195464004509	Class II fumarases; Region: Fumarase_classII; cd01362
1195464004510	active site
1195464004511	tetramer interface [polypeptide binding]; other site
1195464004512	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1195464004513	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1195464004514	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1195464004515	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1195464004516	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1195464004517	active site pocket [active]
1195464004518	oxyanion hole [active]
1195464004519	catalytic triad [active]
1195464004520	active site nucleophile [active]
1195464004521	Protein of unknown function (DUF3942); Region: DUF3942; pfam13078
1195464004522	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1195464004523	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1195464004524	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1195464004525	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1195464004526	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1195464004527	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1195464004528	catalytic residues [active]
1195464004529	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
1195464004530	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1195464004531	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464004532	non-specific DNA binding site [nucleotide binding]; other site
1195464004533	salt bridge; other site
1195464004534	sequence-specific DNA binding site [nucleotide binding]; other site
1195464004535	Cupin domain; Region: Cupin_2; pfam07883
1195464004536	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1195464004537	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1195464004538	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464004539	catalytic residue [active]
1195464004540	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1195464004541	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
1195464004542	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
1195464004543	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464004544	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464004545	DNA binding residues [nucleotide binding]
1195464004546	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464004547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004548	active site
1195464004549	phosphorylation site [posttranslational modification]
1195464004550	intermolecular recognition site; other site
1195464004551	dimerization interface [polypeptide binding]; other site
1195464004552	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464004553	DNA binding residues [nucleotide binding]
1195464004554	dimerization interface [polypeptide binding]; other site
1195464004555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464004556	Histidine kinase; Region: HisKA_3; pfam07730
1195464004557	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1195464004558	Mg2+ binding site [ion binding]; other site
1195464004559	G-X-G motif; other site
1195464004560	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464004561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464004562	Walker A/P-loop; other site
1195464004563	ATP binding site [chemical binding]; other site
1195464004564	Q-loop/lid; other site
1195464004565	ABC transporter signature motif; other site
1195464004566	Walker B; other site
1195464004567	D-loop; other site
1195464004568	H-loop/switch region; other site
1195464004569	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1195464004570	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1195464004571	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1195464004572	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1195464004573	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1195464004574	PLD-like domain; Region: PLDc_2; pfam13091
1195464004575	putative active site [active]
1195464004576	catalytic site [active]
1195464004577	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1195464004578	PLD-like domain; Region: PLDc_2; pfam13091
1195464004579	putative active site [active]
1195464004580	catalytic site [active]
1195464004581	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1195464004582	putative nucleotide binding site [chemical binding]; other site
1195464004583	uridine monophosphate binding site [chemical binding]; other site
1195464004584	homohexameric interface [polypeptide binding]; other site
1195464004585	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1195464004586	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1195464004587	aspartate ammonia-lyase; Provisional; Region: PRK14515
1195464004588	Aspartase; Region: Aspartase; cd01357
1195464004589	active sites [active]
1195464004590	tetramer interface [polypeptide binding]; other site
1195464004591	malate dehydrogenase; Provisional; Region: PRK13529
1195464004592	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1195464004593	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1195464004594	NAD(P) binding site [chemical binding]; other site
1195464004595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464004596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464004597	ATP binding site [chemical binding]; other site
1195464004598	Mg2+ binding site [ion binding]; other site
1195464004599	G-X-G motif; other site
1195464004600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004601	Response regulator receiver domain; Region: Response_reg; pfam00072
1195464004602	active site
1195464004603	phosphorylation site [posttranslational modification]
1195464004604	intermolecular recognition site; other site
1195464004605	dimerization interface [polypeptide binding]; other site
1195464004606	YcbB domain; Region: YcbB; pfam08664
1195464004607	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464004608	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464004609	putative Zn2+ binding site [ion binding]; other site
1195464004610	putative DNA binding site [nucleotide binding]; other site
1195464004611	dimerization interface [polypeptide binding]; other site
1195464004612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004613	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464004614	putative substrate translocation pore; other site
1195464004615	SWIM zinc finger; Region: SWIM; pfam04434
1195464004616	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1195464004617	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1195464004618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464004619	ATP binding site [chemical binding]; other site
1195464004620	putative Mg++ binding site [ion binding]; other site
1195464004621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464004622	nucleotide binding region [chemical binding]; other site
1195464004623	ATP-binding site [chemical binding]; other site
1195464004624	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1195464004625	dimer interface [polypeptide binding]; other site
1195464004626	active site
1195464004627	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464004628	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464004629	non-specific DNA binding site [nucleotide binding]; other site
1195464004630	salt bridge; other site
1195464004631	sequence-specific DNA binding site [nucleotide binding]; other site
1195464004632	aspartate kinase; Reviewed; Region: PRK06635
1195464004633	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1195464004634	putative nucleotide binding site [chemical binding]; other site
1195464004635	putative catalytic residues [active]
1195464004636	putative Mg ion binding site [ion binding]; other site
1195464004637	putative aspartate binding site [chemical binding]; other site
1195464004638	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1195464004639	putative allosteric regulatory site; other site
1195464004640	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1195464004641	putative allosteric regulatory residue; other site
1195464004642	DoxX-like family; Region: DoxX_3; pfam13781
1195464004643	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1195464004644	YndJ-like protein; Region: YndJ; pfam14158
1195464004645	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1195464004646	putative active site [active]
1195464004647	nucleotide binding site [chemical binding]; other site
1195464004648	nudix motif; other site
1195464004649	putative metal binding site [ion binding]; other site
1195464004650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004651	putative substrate translocation pore; other site
1195464004652	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464004653	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1195464004654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004655	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464004656	putative substrate translocation pore; other site
1195464004657	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1195464004658	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1195464004659	dimer interface [polypeptide binding]; other site
1195464004660	active site
1195464004661	CoA binding pocket [chemical binding]; other site
1195464004662	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1195464004663	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1195464004664	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1195464004665	HflX GTPase family; Region: HflX; cd01878
1195464004666	G1 box; other site
1195464004667	GTP/Mg2+ binding site [chemical binding]; other site
1195464004668	Switch I region; other site
1195464004669	G2 box; other site
1195464004670	G3 box; other site
1195464004671	Switch II region; other site
1195464004672	G4 box; other site
1195464004673	G5 box; other site
1195464004674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004675	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464004676	putative substrate translocation pore; other site
1195464004677	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1195464004678	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1195464004679	dimer interface [polypeptide binding]; other site
1195464004680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464004681	catalytic residue [active]
1195464004682	Predicted acetyltransferase [General function prediction only]; Region: COG3981
1195464004683	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
1195464004684	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1195464004685	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1195464004686	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1195464004687	Na2 binding site [ion binding]; other site
1195464004688	putative substrate binding site 1 [chemical binding]; other site
1195464004689	Na binding site 1 [ion binding]; other site
1195464004690	putative substrate binding site 2 [chemical binding]; other site
1195464004691	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464004692	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
1195464004693	NodB motif; other site
1195464004694	putative active site [active]
1195464004695	putative catalytic site [active]
1195464004696	putative Zn binding site [ion binding]; other site
1195464004697	Mor transcription activator family; Region: Mor; cl02360
1195464004698	Predicted membrane protein [Function unknown]; Region: COG2323
1195464004699	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1195464004700	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004701	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004702	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004703	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004704	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004705	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004706	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1195464004707	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1195464004708	short chain dehydrogenase; Provisional; Region: PRK12747
1195464004709	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1195464004710	NADP binding site [chemical binding]; other site
1195464004711	homodimer interface [polypeptide binding]; other site
1195464004712	active site
1195464004713	substrate binding site [chemical binding]; other site
1195464004714	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1195464004715	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1195464004716	homodimer interface [polypeptide binding]; other site
1195464004717	substrate-cofactor binding pocket; other site
1195464004718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464004719	catalytic residue [active]
1195464004720	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725
1195464004721	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1195464004722	PYR/PP interface [polypeptide binding]; other site
1195464004723	dimer interface [polypeptide binding]; other site
1195464004724	TPP binding site [chemical binding]; other site
1195464004725	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1195464004726	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1195464004727	TPP-binding site [chemical binding]; other site
1195464004728	dimer interface [polypeptide binding]; other site
1195464004729	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1195464004730	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1195464004731	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1195464004732	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1195464004733	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1195464004734	threonine dehydratase; Validated; Region: PRK08639
1195464004735	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1195464004736	tetramer interface [polypeptide binding]; other site
1195464004737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464004738	catalytic residue [active]
1195464004739	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1195464004740	putative Ile/Val binding site [chemical binding]; other site
1195464004741	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1195464004742	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1195464004743	putative active site [active]
1195464004744	putative metal binding site [ion binding]; other site
1195464004745	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1195464004746	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464004747	Coenzyme A binding pocket [chemical binding]; other site
1195464004748	drug efflux system protein MdtG; Provisional; Region: PRK09874
1195464004749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464004750	putative substrate translocation pore; other site
1195464004751	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1195464004752	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1195464004753	putative active site [active]
1195464004754	metal binding site [ion binding]; metal-binding site
1195464004755	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1195464004756	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1195464004757	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1195464004758	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1195464004759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464004760	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464004761	Coenzyme A binding pocket [chemical binding]; other site
1195464004762	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1195464004763	5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493
1195464004764	active site
1195464004765	putative substrate binding pocket [chemical binding]; other site
1195464004766	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464004767	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464004768	peptide binding site [polypeptide binding]; other site
1195464004769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464004770	S-adenosylmethionine binding site [chemical binding]; other site
1195464004771	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1195464004772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464004773	FeS/SAM binding site; other site
1195464004774	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1195464004775	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464004776	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464004777	Coenzyme A binding pocket [chemical binding]; other site
1195464004778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464004779	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464004780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004781	active site
1195464004782	phosphorylation site [posttranslational modification]
1195464004783	intermolecular recognition site; other site
1195464004784	dimerization interface [polypeptide binding]; other site
1195464004785	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464004786	DNA binding site [nucleotide binding]
1195464004787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464004788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464004789	dimer interface [polypeptide binding]; other site
1195464004790	phosphorylation site [posttranslational modification]
1195464004791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464004792	ATP binding site [chemical binding]; other site
1195464004793	Mg2+ binding site [ion binding]; other site
1195464004794	G-X-G motif; other site
1195464004795	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464004796	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464004797	manganese transport protein MntH; Reviewed; Region: PRK00701
1195464004798	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1195464004799	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1195464004800	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1195464004801	active site residue [active]
1195464004802	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1195464004803	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1195464004804	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1195464004805	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1195464004806	Amino acid permease; Region: AA_permease_2; pfam13520
1195464004807	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464004808	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464004809	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464004810	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1195464004811	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1195464004812	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464004813	DNA binding residues [nucleotide binding]
1195464004814	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1195464004815	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1195464004816	intersubunit interface [polypeptide binding]; other site
1195464004817	active site
1195464004818	catalytic residue [active]
1195464004819	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1195464004820	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1195464004821	Nucleoside recognition; Region: Gate; pfam07670
1195464004822	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464004823	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1195464004824	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1195464004825	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1195464004826	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1195464004827	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1195464004828	active site
1195464004829	catalytic motif [active]
1195464004830	Zn binding site [ion binding]; other site
1195464004831	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
1195464004832	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1195464004833	hypothetical protein; Provisional; Region: PRK01631
1195464004834	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1195464004835	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464004836	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464004837	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464004838	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464004839	dimerization interface [polypeptide binding]; other site
1195464004840	Family description; Region: DsbD_2; pfam13386
1195464004841	VPS10 domain; Region: VPS10; smart00602
1195464004842	proline aminopeptidase P II; Provisional; Region: PRK10879
1195464004843	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
1195464004844	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1195464004845	active site
1195464004846	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1195464004847	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1195464004848	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1195464004849	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1195464004850	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464004851	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464004852	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464004853	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464004854	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464004855	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1195464004856	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1195464004857	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464004858	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1195464004859	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1195464004860	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1195464004861	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1195464004862	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1195464004863	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1195464004864	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1195464004865	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1195464004866	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1195464004867	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1195464004868	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1195464004869	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464004870	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464004871	Walker A/P-loop; other site
1195464004872	ATP binding site [chemical binding]; other site
1195464004873	Q-loop/lid; other site
1195464004874	ABC transporter signature motif; other site
1195464004875	Walker B; other site
1195464004876	D-loop; other site
1195464004877	H-loop/switch region; other site
1195464004878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464004879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004880	active site
1195464004881	phosphorylation site [posttranslational modification]
1195464004882	intermolecular recognition site; other site
1195464004883	dimerization interface [polypeptide binding]; other site
1195464004884	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464004885	DNA binding site [nucleotide binding]
1195464004886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464004887	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464004888	dimer interface [polypeptide binding]; other site
1195464004889	phosphorylation site [posttranslational modification]
1195464004890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464004891	ATP binding site [chemical binding]; other site
1195464004892	Mg2+ binding site [ion binding]; other site
1195464004893	G-X-G motif; other site
1195464004894	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1195464004895	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1195464004896	active site
1195464004897	ATP binding site [chemical binding]; other site
1195464004898	substrate binding site [chemical binding]; other site
1195464004899	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1195464004900	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464004901	Presynaptic Site I dimer interface [polypeptide binding]; other site
1195464004902	catalytic residues [active]
1195464004903	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1195464004904	Synaptic Flat tetramer interface [polypeptide binding]; other site
1195464004905	Synaptic Site I dimer interface [polypeptide binding]; other site
1195464004906	DNA binding site [nucleotide binding]
1195464004907	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
1195464004908	Zn binding site [ion binding]; other site
1195464004909	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1195464004910	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1195464004911	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1195464004912	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1195464004913	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1195464004914	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1195464004915	Divalent cation transporter; Region: MgtE; pfam01769
1195464004916	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1195464004917	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1195464004918	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1195464004919	VPS10 domain; Region: VPS10; smart00602
1195464004920	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464004921	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464004922	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464004923	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464004924	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464004925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464004926	Histidine kinase; Region: HisKA_3; pfam07730
1195464004927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464004928	ATP binding site [chemical binding]; other site
1195464004929	Mg2+ binding site [ion binding]; other site
1195464004930	G-X-G motif; other site
1195464004931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464004932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464004933	active site
1195464004934	phosphorylation site [posttranslational modification]
1195464004935	intermolecular recognition site; other site
1195464004936	dimerization interface [polypeptide binding]; other site
1195464004937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464004938	DNA binding residues [nucleotide binding]
1195464004939	dimerization interface [polypeptide binding]; other site
1195464004940	Putative sensor; Region: Sensor; pfam13796
1195464004941	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1195464004942	CAAX protease self-immunity; Region: Abi; pfam02517
1195464004943	DNA topoisomerase III; Provisional; Region: PRK07726
1195464004944	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1195464004945	active site
1195464004946	putative interdomain interaction site [polypeptide binding]; other site
1195464004947	putative metal-binding site [ion binding]; other site
1195464004948	putative nucleotide binding site [chemical binding]; other site
1195464004949	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464004950	domain I; other site
1195464004951	DNA binding groove [nucleotide binding]
1195464004952	phosphate binding site [ion binding]; other site
1195464004953	domain II; other site
1195464004954	domain III; other site
1195464004955	nucleotide binding site [chemical binding]; other site
1195464004956	catalytic site [active]
1195464004957	domain IV; other site
1195464004958	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464004959	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1195464004960	Predicted membrane protein [Function unknown]; Region: COG2364
1195464004961	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464004962	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464004963	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464004964	dimerization interface [polypeptide binding]; other site
1195464004965	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1195464004966	Sodium Bile acid symporter family; Region: SBF; cl17470
1195464004967	azoreductase; Provisional; Region: PRK13555
1195464004968	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464004969	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464004970	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1195464004971	dimer interface [polypeptide binding]; other site
1195464004972	substrate binding site [chemical binding]; other site
1195464004973	metal binding site [ion binding]; metal-binding site
1195464004974	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
1195464004975	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1195464004976	YtkA-like; Region: YtkA; pfam13115
1195464004977	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1195464004978	EamA-like transporter family; Region: EamA; pfam00892
1195464004979	EamA-like transporter family; Region: EamA; pfam00892
1195464004980	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464004981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464004982	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464004983	dimerization interface [polypeptide binding]; other site
1195464004984	Rrf2 family protein; Region: rrf2_super; TIGR00738
1195464004985	Transcriptional regulator; Region: Rrf2; pfam02082
1195464004986	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1195464004987	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1195464004988	catalytic residues [active]
1195464004989	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1195464004990	dimer interface [polypeptide binding]; other site
1195464004991	FMN binding site [chemical binding]; other site
1195464004992	amidase; Provisional; Region: PRK06707
1195464004993	Amidase; Region: Amidase; cl11426
1195464004994	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1195464004995	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1195464004996	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1195464004997	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464004998	NAD binding site [chemical binding]; other site
1195464004999	dimer interface [polypeptide binding]; other site
1195464005000	substrate binding site [chemical binding]; other site
1195464005001	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1195464005002	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464005003	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1195464005004	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1195464005005	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1195464005006	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1195464005007	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
1195464005008	putative ligand binding site [chemical binding]; other site
1195464005009	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1195464005010	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1195464005011	Walker A/P-loop; other site
1195464005012	ATP binding site [chemical binding]; other site
1195464005013	Q-loop/lid; other site
1195464005014	ABC transporter signature motif; other site
1195464005015	Walker B; other site
1195464005016	D-loop; other site
1195464005017	H-loop/switch region; other site
1195464005018	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1195464005019	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1195464005020	Walker A/P-loop; other site
1195464005021	ATP binding site [chemical binding]; other site
1195464005022	Q-loop/lid; other site
1195464005023	ABC transporter signature motif; other site
1195464005024	Walker B; other site
1195464005025	D-loop; other site
1195464005026	H-loop/switch region; other site
1195464005027	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464005028	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1195464005029	TM-ABC transporter signature motif; other site
1195464005030	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1195464005031	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1195464005032	TM-ABC transporter signature motif; other site
1195464005033	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464005034	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464005035	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1195464005036	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464005037	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464005038	putative Zn2+ binding site [ion binding]; other site
1195464005039	putative DNA binding site [nucleotide binding]; other site
1195464005040	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1195464005041	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1195464005042	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1195464005043	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1195464005044	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1195464005045	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1195464005046	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1195464005047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464005048	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1195464005049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464005050	Walker A/P-loop; other site
1195464005051	ATP binding site [chemical binding]; other site
1195464005052	Q-loop/lid; other site
1195464005053	ABC transporter signature motif; other site
1195464005054	Walker B; other site
1195464005055	D-loop; other site
1195464005056	H-loop/switch region; other site
1195464005057	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1195464005058	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464005059	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1195464005060	Walker A/P-loop; other site
1195464005061	ATP binding site [chemical binding]; other site
1195464005062	Q-loop/lid; other site
1195464005063	ABC transporter signature motif; other site
1195464005064	Walker B; other site
1195464005065	D-loop; other site
1195464005066	H-loop/switch region; other site
1195464005067	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1195464005068	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1195464005069	active site
1195464005070	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464005071	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464005072	active site
1195464005073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464005074	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464005075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1195464005076	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
1195464005077	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1195464005078	putative dimer interface [polypeptide binding]; other site
1195464005079	catalytic triad [active]
1195464005080	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464005081	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1195464005082	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1195464005083	dimer interface [polypeptide binding]; other site
1195464005084	FMN binding site [chemical binding]; other site
1195464005085	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464005086	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464005087	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464005088	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464005089	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464005090	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464005091	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464005092	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464005093	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464005094	Walker A/P-loop; other site
1195464005095	ATP binding site [chemical binding]; other site
1195464005096	Q-loop/lid; other site
1195464005097	ABC transporter signature motif; other site
1195464005098	Walker B; other site
1195464005099	D-loop; other site
1195464005100	H-loop/switch region; other site
1195464005101	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464005102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464005103	active site
1195464005104	phosphorylation site [posttranslational modification]
1195464005105	intermolecular recognition site; other site
1195464005106	dimerization interface [polypeptide binding]; other site
1195464005107	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464005108	DNA binding site [nucleotide binding]
1195464005109	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464005110	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464005111	dimerization interface [polypeptide binding]; other site
1195464005112	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464005113	dimer interface [polypeptide binding]; other site
1195464005114	phosphorylation site [posttranslational modification]
1195464005115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464005116	ATP binding site [chemical binding]; other site
1195464005117	Mg2+ binding site [ion binding]; other site
1195464005118	G-X-G motif; other site
1195464005119	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
1195464005120	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
1195464005121	classical (c) SDRs; Region: SDR_c; cd05233
1195464005122	NAD(P) binding site [chemical binding]; other site
1195464005123	active site
1195464005124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464005125	S-adenosylmethionine binding site [chemical binding]; other site
1195464005126	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1195464005127	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464005128	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1195464005129	NodB motif; other site
1195464005130	active site
1195464005131	catalytic site [active]
1195464005132	metal binding site [ion binding]; metal-binding site
1195464005133	SdpI/YhfL protein family; Region: SdpI; pfam13630
1195464005134	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1195464005135	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464005136	nudix motif; other site
1195464005137	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
1195464005138	homoserine dehydrogenase; Provisional; Region: PRK06349
1195464005139	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1195464005140	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1195464005141	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1195464005142	threonine synthase; Reviewed; Region: PRK06721
1195464005143	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1195464005144	homodimer interface [polypeptide binding]; other site
1195464005145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464005146	catalytic residue [active]
1195464005147	homoserine kinase; Provisional; Region: PRK01212
1195464005148	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1195464005149	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1195464005150	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1195464005151	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1195464005152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464005153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464005154	active site
1195464005155	phosphorylation site [posttranslational modification]
1195464005156	intermolecular recognition site; other site
1195464005157	dimerization interface [polypeptide binding]; other site
1195464005158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464005159	DNA binding site [nucleotide binding]
1195464005160	HAMP domain; Region: HAMP; pfam00672
1195464005161	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464005162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464005163	dimer interface [polypeptide binding]; other site
1195464005164	phosphorylation site [posttranslational modification]
1195464005165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464005166	ATP binding site [chemical binding]; other site
1195464005167	Mg2+ binding site [ion binding]; other site
1195464005168	G-X-G motif; other site
1195464005169	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464005170	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1195464005171	NodB motif; other site
1195464005172	active site
1195464005173	catalytic site [active]
1195464005174	Zn binding site [ion binding]; other site
1195464005175	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1195464005176	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1195464005177	MgtC family; Region: MgtC; pfam02308
1195464005178	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1195464005179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005180	Coenzyme A binding pocket [chemical binding]; other site
1195464005181	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1195464005182	IucA / IucC family; Region: IucA_IucC; pfam04183
1195464005183	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1195464005184	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1195464005185	IucA / IucC family; Region: IucA_IucC; pfam04183
1195464005186	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1195464005187	acyl-CoA synthetase; Validated; Region: PRK08308
1195464005188	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1195464005189	acyl-activating enzyme (AAE) consensus motif; other site
1195464005190	AMP binding site [chemical binding]; other site
1195464005191	active site
1195464005192	CoA binding site [chemical binding]; other site
1195464005193	acyl carrier protein; Provisional; Region: PRK07639
1195464005194	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1195464005195	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1195464005196	Metal-binding active site; metal-binding site
1195464005197	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1195464005198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464005199	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464005200	putative substrate translocation pore; other site
1195464005201	Lysine efflux permease [General function prediction only]; Region: COG1279
1195464005202	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464005203	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464005204	DNA-binding site [nucleotide binding]; DNA binding site
1195464005205	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464005206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464005207	homodimer interface [polypeptide binding]; other site
1195464005208	catalytic residue [active]
1195464005209	Protein of unknown function (DUF3933); Region: DUF3933; pfam13069
1195464005210	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1195464005211	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1195464005212	active site
1195464005213	nucleophile elbow; other site
1195464005214	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1195464005215	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
1195464005216	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1195464005217	Domain of unknown function (DUF4083); Region: DUF4083; pfam13314
1195464005218	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1195464005219	nudix motif; other site
1195464005220	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1195464005221	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1195464005222	homodimer interface [polypeptide binding]; other site
1195464005223	NAD binding pocket [chemical binding]; other site
1195464005224	ATP binding pocket [chemical binding]; other site
1195464005225	Mg binding site [ion binding]; other site
1195464005226	active-site loop [active]
1195464005227	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1195464005228	Phage terminase, small subunit; Region: Terminase_4; cl01525
1195464005229	Phage portal protein; Region: Phage_portal; pfam04860
1195464005230	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1195464005231	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
1195464005232	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1195464005233	Phage capsid family; Region: Phage_capsid; pfam05065
1195464005234	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464005235	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1195464005236	catalytic residues [active]
1195464005237	catalytic nucleophile [active]
1195464005238	Recombinase; Region: Recombinase; pfam07508
1195464005239	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1195464005240	FtsX-like permease family; Region: FtsX; pfam02687
1195464005241	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1195464005242	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464005243	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1195464005244	active site
1195464005245	catalytic residues [active]
1195464005246	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464005247	dimerization interface [polypeptide binding]; other site
1195464005248	putative DNA binding site [nucleotide binding]; other site
1195464005249	putative Zn2+ binding site [ion binding]; other site
1195464005250	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464005251	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464005252	active site
1195464005253	catalytic tetrad [active]
1195464005254	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
1195464005255	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1195464005256	DinB superfamily; Region: DinB_2; pfam12867
1195464005257	GTPase RsgA; Reviewed; Region: PRK01889
1195464005258	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1195464005259	RNA binding site [nucleotide binding]; other site
1195464005260	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1195464005261	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1195464005262	GTP/Mg2+ binding site [chemical binding]; other site
1195464005263	G4 box; other site
1195464005264	G5 box; other site
1195464005265	G1 box; other site
1195464005266	Switch I region; other site
1195464005267	G2 box; other site
1195464005268	G3 box; other site
1195464005269	Switch II region; other site
1195464005270	Tar ligand binding domain homologue; Region: TarH; pfam02203
1195464005271	Cache domain; Region: Cache_1; pfam02743
1195464005272	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1195464005273	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464005274	dimerization interface [polypeptide binding]; other site
1195464005275	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464005276	dimer interface [polypeptide binding]; other site
1195464005277	putative CheW interface [polypeptide binding]; other site
1195464005278	Protein of unknown function (DUF3979); Region: DUF3979; pfam13141
1195464005279	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1195464005280	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1195464005281	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1195464005282	dimerization interface [polypeptide binding]; other site
1195464005283	DPS ferroxidase diiron center [ion binding]; other site
1195464005284	ion pore; other site
1195464005285	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
1195464005286	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1195464005287	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1195464005288	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1195464005289	Protein of unknown function (DUF3896); Region: DUF3896; pfam13035
1195464005290	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1195464005291	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464005292	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464005293	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464005294	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464005295	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464005296	active site
1195464005297	catalytic tetrad [active]
1195464005298	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1195464005299	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1195464005300	P-loop, Walker A motif; other site
1195464005301	Base recognition motif; other site
1195464005302	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1195464005303	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464005304	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005305	Coenzyme A binding pocket [chemical binding]; other site
1195464005306	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1195464005307	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1195464005308	metal binding site [ion binding]; metal-binding site
1195464005309	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1195464005310	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1195464005311	NAD binding site [chemical binding]; other site
1195464005312	active site
1195464005313	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1195464005314	homotetramer interface [polypeptide binding]; other site
1195464005315	active site
1195464005316	substrate binding site [chemical binding]; other site
1195464005317	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1195464005318	FMN binding site [chemical binding]; other site
1195464005319	catalytic residue [active]
1195464005320	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1195464005321	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1195464005322	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1195464005323	DNA binding site [nucleotide binding]
1195464005324	active site
1195464005325	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
1195464005326	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464005327	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464005328	peptide binding site [polypeptide binding]; other site
1195464005329	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1195464005330	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464005331	active site
1195464005332	metal binding site [ion binding]; metal-binding site
1195464005333	short chain dehydrogenase; Provisional; Region: PRK08309
1195464005334	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464005335	catalytic core [active]
1195464005336	CotH protein; Region: CotH; pfam08757
1195464005337	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1195464005338	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1195464005339	nudix motif; other site
1195464005340	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464005341	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464005342	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1195464005343	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1195464005344	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1195464005345	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1195464005346	Cl binding site [ion binding]; other site
1195464005347	oligomer interface [polypeptide binding]; other site
1195464005348	Predicted permeases [General function prediction only]; Region: COG0701
1195464005349	Predicted membrane protein [Function unknown]; Region: COG3689
1195464005350	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1195464005351	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1195464005352	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1195464005353	putative active site [active]
1195464005354	catalytic site [active]
1195464005355	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1195464005356	putative active site [active]
1195464005357	catalytic site [active]
1195464005358	Coat F domain; Region: Coat_F; pfam07875
1195464005359	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1195464005360	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1195464005361	NAD binding site [chemical binding]; other site
1195464005362	substrate binding site [chemical binding]; other site
1195464005363	putative active site [active]
1195464005364	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1195464005365	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1195464005366	Domain of unknown function DUF21; Region: DUF21; pfam01595
1195464005367	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1195464005368	Transporter associated domain; Region: CorC_HlyC; smart01091
1195464005369	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464005370	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464005371	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1195464005372	FOG: CBS domain [General function prediction only]; Region: COG0517
1195464005373	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1195464005374	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464005375	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1195464005376	dimer interface [polypeptide binding]; other site
1195464005377	putative tRNA-binding site [nucleotide binding]; other site
1195464005378	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1195464005379	DinB superfamily; Region: DinB_2; pfam12867
1195464005380	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1195464005381	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1195464005382	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464005383	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005384	Coenzyme A binding pocket [chemical binding]; other site
1195464005385	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1195464005386	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1195464005387	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464005388	nudix motif; other site
1195464005389	amidase; Provisional; Region: PRK06828
1195464005390	Amidase; Region: Amidase; pfam01425
1195464005391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464005392	putative substrate translocation pore; other site
1195464005393	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1195464005394	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1195464005395	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1195464005396	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1195464005397	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1195464005398	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464005399	catalytic core [active]
1195464005400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464005401	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464005402	active site
1195464005403	motif I; other site
1195464005404	motif II; other site
1195464005405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464005406	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464005407	MarR family; Region: MarR; pfam01047
1195464005408	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464005409	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464005410	putative substrate translocation pore; other site
1195464005411	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1195464005412	alanine racemase; Reviewed; Region: alr; PRK00053
1195464005413	active site
1195464005414	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1195464005415	dimer interface [polypeptide binding]; other site
1195464005416	substrate binding site [chemical binding]; other site
1195464005417	catalytic residues [active]
1195464005418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005419	Coenzyme A binding pocket [chemical binding]; other site
1195464005420	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1195464005421	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005422	Coenzyme A binding pocket [chemical binding]; other site
1195464005423	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1195464005424	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1195464005425	active site
1195464005426	TDP-binding site; other site
1195464005427	acceptor substrate-binding pocket; other site
1195464005428	homodimer interface [polypeptide binding]; other site
1195464005429	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464005430	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464005431	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464005432	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464005433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464005434	DNA-binding site [nucleotide binding]; DNA binding site
1195464005435	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464005436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464005437	homodimer interface [polypeptide binding]; other site
1195464005438	catalytic residue [active]
1195464005439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005440	Coenzyme A binding pocket [chemical binding]; other site
1195464005441	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464005442	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1195464005443	active site
1195464005444	metal binding site [ion binding]; metal-binding site
1195464005445	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464005446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005447	Coenzyme A binding pocket [chemical binding]; other site
1195464005448	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1195464005449	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464005450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005451	Coenzyme A binding pocket [chemical binding]; other site
1195464005452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005453	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464005454	Coenzyme A binding pocket [chemical binding]; other site
1195464005455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1195464005456	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
1195464005457	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1195464005458	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; pfam10661
1195464005459	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
1195464005460	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1195464005461	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140
1195464005462	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1195464005463	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1195464005464	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464005465	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464005466	Domain of unknown function (DUF3952); Region: DUF3952; pfam13130
1195464005467	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1195464005468	active site flap/lid [active]
1195464005469	nucleophilic elbow; other site
1195464005470	catalytic triad [active]
1195464005471	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
1195464005472	Domain of unknown function (DUF3952); Region: DUF3952; pfam13130
1195464005473	Domain of unknown function (DUF3952); Region: DUF3952; pfam13130
1195464005474	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1195464005475	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005476	Coenzyme A binding pocket [chemical binding]; other site
1195464005477	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1195464005478	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464005479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464005480	S-adenosylmethionine binding site [chemical binding]; other site
1195464005481	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1195464005482	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1195464005483	Potassium binding sites [ion binding]; other site
1195464005484	Cesium cation binding sites [ion binding]; other site
1195464005485	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1195464005486	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1195464005487	ATP binding site [chemical binding]; other site
1195464005488	putative Mg++ binding site [ion binding]; other site
1195464005489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464005490	nucleotide binding region [chemical binding]; other site
1195464005491	ATP-binding site [chemical binding]; other site
1195464005492	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464005493	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1195464005494	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
1195464005495	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464005496	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1195464005497	NADP binding site [chemical binding]; other site
1195464005498	dimer interface [polypeptide binding]; other site
1195464005499	RNA polymerase sigma factor; Provisional; Region: PRK12543
1195464005500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1195464005501	Domain of unknown function (DUF3600); Region: DUF3600; pfam12207
1195464005502	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1195464005503	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464005504	Protein of unknown function (DUF3925); Region: DUF3925; pfam13063
1195464005505	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1195464005506	catalytic residues [active]
1195464005507	dimer interface [polypeptide binding]; other site
1195464005508	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1195464005509	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1195464005510	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1195464005511	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1195464005512	Protein of unknown function DUF58; Region: DUF58; pfam01882
1195464005513	MoxR-like ATPases [General function prediction only]; Region: COG0714
1195464005514	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464005515	Walker A motif; other site
1195464005516	ATP binding site [chemical binding]; other site
1195464005517	Walker B motif; other site
1195464005518	arginine finger; other site
1195464005519	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1195464005520	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1195464005521	[4Fe-4S] binding site [ion binding]; other site
1195464005522	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1195464005523	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1195464005524	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1195464005525	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1195464005526	molybdopterin cofactor binding site; other site
1195464005527	nitrate reductase, beta subunit; Region: narH; TIGR01660
1195464005528	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1195464005529	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1195464005530	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1195464005531	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464005532	ligand binding site [chemical binding]; other site
1195464005533	flexible hinge region; other site
1195464005534	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1195464005535	putative switch regulator; other site
1195464005536	non-specific DNA interactions [nucleotide binding]; other site
1195464005537	DNA binding site [nucleotide binding]
1195464005538	sequence specific DNA binding site [nucleotide binding]; other site
1195464005539	putative cAMP binding site [chemical binding]; other site
1195464005540	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1195464005541	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464005542	FeS/SAM binding site; other site
1195464005543	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1195464005544	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1195464005545	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1195464005546	ATP binding site [chemical binding]; other site
1195464005547	substrate interface [chemical binding]; other site
1195464005548	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1195464005549	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1195464005550	dimer interface [polypeptide binding]; other site
1195464005551	putative functional site; other site
1195464005552	putative MPT binding site; other site
1195464005553	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1195464005554	MoaE homodimer interface [polypeptide binding]; other site
1195464005555	MoaD interaction [polypeptide binding]; other site
1195464005556	active site residues [active]
1195464005557	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1195464005558	MoaE interaction surface [polypeptide binding]; other site
1195464005559	MoeB interaction surface [polypeptide binding]; other site
1195464005560	thiocarboxylated glycine; other site
1195464005561	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1195464005562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464005563	putative substrate translocation pore; other site
1195464005564	precorrin-2 dehydrogenase; Validated; Region: PRK06719
1195464005565	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1195464005566	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1195464005567	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1195464005568	putative active site [active]
1195464005569	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1195464005570	putative active site [active]
1195464005571	bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168
1195464005572	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1195464005573	active site
1195464005574	SAM binding site [chemical binding]; other site
1195464005575	homodimer interface [polypeptide binding]; other site
1195464005576	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1195464005577	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1195464005578	[2Fe-2S] cluster binding site [ion binding]; other site
1195464005579	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1195464005580	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464005581	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1195464005582	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1195464005583	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1195464005584	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1195464005585	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1195464005586	Hemerythrin-like domain; Region: Hr-like; cd12108
1195464005587	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
1195464005588	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1195464005589	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1195464005590	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1195464005591	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464005592	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464005593	TIR domain; Region: TIR_2; cl17458
1195464005594	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1195464005595	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1195464005596	PGAP1-like protein; Region: PGAP1; pfam07819
1195464005597	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1195464005598	DNA translocase FtsK; Provisional; Region: PRK10263
1195464005599	DNA translocase FtsK; Provisional; Region: PRK10263
1195464005600	DNA translocase FtsK; Provisional; Region: PRK10263
1195464005601	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1195464005602	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464005603	Zn2+ binding site [ion binding]; other site
1195464005604	Mg2+ binding site [ion binding]; other site
1195464005605	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464005606	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464005607	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464005608	ABC transporter; Region: ABC_tran_2; pfam12848
1195464005609	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464005610	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1195464005611	Domain of unknown function (DUF4318); Region: DUF4318; pfam14201
1195464005612	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1195464005613	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1195464005614	dimer interface [polypeptide binding]; other site
1195464005615	ssDNA binding site [nucleotide binding]; other site
1195464005616	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464005617	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1195464005618	Virulence factor; Region: Virulence_fact; pfam13769
1195464005619	HEAT repeats; Region: HEAT_2; pfam13646
1195464005620	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1195464005621	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1195464005622	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1195464005623	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1195464005624	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1195464005625	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1195464005626	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1195464005627	active site
1195464005628	HIGH motif; other site
1195464005629	KMSK motif region; other site
1195464005630	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1195464005631	tRNA binding surface [nucleotide binding]; other site
1195464005632	anticodon binding site; other site
1195464005633	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464005634	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1195464005635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464005636	binding surface
1195464005637	TPR motif; other site
1195464005638	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1195464005639	putative active site [active]
1195464005640	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464005641	binding surface
1195464005642	TPR motif; other site
1195464005643	TPR repeat; Region: TPR_11; pfam13414
1195464005644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464005645	binding surface
1195464005646	TPR motif; other site
1195464005647	TPR repeat; Region: TPR_11; pfam13414
1195464005648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464005649	binding surface
1195464005650	TPR motif; other site
1195464005651	TPR repeat; Region: TPR_11; pfam13414
1195464005652	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464005653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464005654	binding surface
1195464005655	TPR motif; other site
1195464005656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464005657	binding surface
1195464005658	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1195464005659	TPR motif; other site
1195464005660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464005661	binding surface
1195464005662	TPR motif; other site
1195464005663	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
1195464005664	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1195464005665	HIGH motif; other site
1195464005666	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1195464005667	active site
1195464005668	KMSKS motif; other site
1195464005669	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1195464005670	tRNA binding surface [nucleotide binding]; other site
1195464005671	anticodon binding site; other site
1195464005672	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1195464005673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464005674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464005675	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464005676	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464005677	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1195464005678	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
1195464005679	Zn binding site [ion binding]; other site
1195464005680	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
1195464005681	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1195464005682	Dimer interface [polypeptide binding]; other site
1195464005683	anticodon binding site; other site
1195464005684	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1195464005685	homodimer interface [polypeptide binding]; other site
1195464005686	motif 1; other site
1195464005687	motif 2; other site
1195464005688	active site
1195464005689	motif 3; other site
1195464005690	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1195464005691	Na2 binding site [ion binding]; other site
1195464005692	putative substrate binding site 1 [chemical binding]; other site
1195464005693	Na binding site 1 [ion binding]; other site
1195464005694	putative substrate binding site 2 [chemical binding]; other site
1195464005695	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464005696	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1195464005697	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1195464005698	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1195464005699	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464005700	motif II; other site
1195464005701	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1195464005702	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1195464005703	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1195464005704	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1195464005705	active site
1195464005706	NAD binding site [chemical binding]; other site
1195464005707	metal binding site [ion binding]; metal-binding site
1195464005708	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1195464005709	aspartate racemase; Region: asp_race; TIGR00035
1195464005710	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1195464005711	homodimer interaction site [polypeptide binding]; other site
1195464005712	cofactor binding site; other site
1195464005713	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464005714	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464005715	hypothetical protein; Validated; Region: PRK06769
1195464005716	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464005717	active site
1195464005718	motif I; other site
1195464005719	motif II; other site
1195464005720	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464005721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464005722	Coenzyme A binding pocket [chemical binding]; other site
1195464005723	YpjP-like protein; Region: YpjP; pfam14005
1195464005724	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1195464005725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464005726	motif II; other site
1195464005727	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1195464005728	putative dimer interface [polypeptide binding]; other site
1195464005729	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464005730	ligand binding site [chemical binding]; other site
1195464005731	Zn binding site [ion binding]; other site
1195464005732	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464005733	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464005734	substrate binding site [chemical binding]; other site
1195464005735	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464005736	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464005737	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1195464005738	thymidylate synthase; Region: thym_sym; TIGR03284
1195464005739	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1195464005740	dimerization interface [polypeptide binding]; other site
1195464005741	active site
1195464005742	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1195464005743	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1195464005744	folate binding site [chemical binding]; other site
1195464005745	NADP+ binding site [chemical binding]; other site
1195464005746	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1195464005747	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464005748	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1195464005749	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464005750	azoreductase; Reviewed; Region: PRK00170
1195464005751	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464005752	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1195464005753	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1195464005754	putative acyl-acceptor binding pocket; other site
1195464005755	Haemolysin-III related; Region: HlyIII; cl03831
1195464005756	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1195464005757	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1195464005758	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1195464005759	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
1195464005760	EDD domain protein, DegV family; Region: DegV; TIGR00762
1195464005761	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1195464005762	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1195464005763	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1195464005764	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1195464005765	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1195464005766	Cu(I) binding site [ion binding]; other site
1195464005767	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1195464005768	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1195464005769	putative dimer interface [polypeptide binding]; other site
1195464005770	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1195464005771	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1195464005772	active site
1195464005773	dimer interface [polypeptide binding]; other site
1195464005774	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1195464005775	Ligand Binding Site [chemical binding]; other site
1195464005776	Molecular Tunnel; other site
1195464005777	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1195464005778	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1195464005779	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1195464005780	active site
1195464005781	metal binding site [ion binding]; metal-binding site
1195464005782	Bacterial SH3 domain; Region: SH3_3; cl17532
1195464005783	Bacterial SH3 domain; Region: SH3_3; cl17532
1195464005784	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464005785	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1195464005786	siderophore binding site; other site
1195464005787	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1195464005788	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1195464005789	homodimer interface [polypeptide binding]; other site
1195464005790	substrate-cofactor binding pocket; other site
1195464005791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464005792	catalytic residue [active]
1195464005793	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1195464005794	FMN binding site [chemical binding]; other site
1195464005795	dimer interface [polypeptide binding]; other site
1195464005796	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464005797	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1195464005798	catalytic triad [active]
1195464005799	conserved cis-peptide bond; other site
1195464005800	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1195464005801	nudix motif; other site
1195464005802	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1195464005803	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1195464005804	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1195464005805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464005806	Histidine kinase; Region: HisKA_3; pfam07730
1195464005807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464005808	ATP binding site [chemical binding]; other site
1195464005809	Mg2+ binding site [ion binding]; other site
1195464005810	G-X-G motif; other site
1195464005811	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464005812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464005813	active site
1195464005814	phosphorylation site [posttranslational modification]
1195464005815	intermolecular recognition site; other site
1195464005816	dimerization interface [polypeptide binding]; other site
1195464005817	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464005818	DNA binding residues [nucleotide binding]
1195464005819	dimerization interface [polypeptide binding]; other site
1195464005820	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1195464005821	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1195464005822	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1195464005823	putative active site [active]
1195464005824	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1195464005825	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1195464005826	NAD binding site [chemical binding]; other site
1195464005827	substrate binding site [chemical binding]; other site
1195464005828	catalytic Zn binding site [ion binding]; other site
1195464005829	tetramer interface [polypeptide binding]; other site
1195464005830	structural Zn binding site [ion binding]; other site
1195464005831	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1195464005832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464005833	dimer interface [polypeptide binding]; other site
1195464005834	conserved gate region; other site
1195464005835	ABC-ATPase subunit interface; other site
1195464005836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1195464005837	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464005838	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464005839	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464005840	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1195464005841	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1195464005842	Protein of unknown function (DUF2711); Region: DUF2711; pfam10924
1195464005843	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464005844	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464005845	active site
1195464005846	Predicted flavoprotein [General function prediction only]; Region: COG0431
1195464005847	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464005848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464005849	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464005850	putative substrate translocation pore; other site
1195464005851	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1195464005852	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1195464005853	putative active site [active]
1195464005854	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1195464005855	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1195464005856	Walker A/P-loop; other site
1195464005857	ATP binding site [chemical binding]; other site
1195464005858	Q-loop/lid; other site
1195464005859	ABC transporter signature motif; other site
1195464005860	Walker B; other site
1195464005861	D-loop; other site
1195464005862	H-loop/switch region; other site
1195464005863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464005864	dimer interface [polypeptide binding]; other site
1195464005865	conserved gate region; other site
1195464005866	ABC-ATPase subunit interface; other site
1195464005867	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1195464005868	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1195464005869	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1195464005870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1195464005871	Protein of unknown function (DUF524); Region: DUF524; pfam04411
1195464005872	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
1195464005873	Helix-turn-helix domain; Region: HTH_17; cl17695
1195464005874	Haemagglutinin; Region: Hemagglutinin; pfam00509
1195464005875	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1195464005876	Domain of unknown function DUF21; Region: DUF21; pfam01595
1195464005877	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1195464005878	Transporter associated domain; Region: CorC_HlyC; smart01091
1195464005879	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
1195464005880	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1195464005881	NAD(P) binding site [chemical binding]; other site
1195464005882	catalytic residues [active]
1195464005883	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1195464005884	Histidine kinase N terminal; Region: HisK_N; pfam09385
1195464005885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464005886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464005887	dimer interface [polypeptide binding]; other site
1195464005888	phosphorylation site [posttranslational modification]
1195464005889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464005890	ATP binding site [chemical binding]; other site
1195464005891	Mg2+ binding site [ion binding]; other site
1195464005892	G-X-G motif; other site
1195464005893	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1195464005894	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1195464005895	hypothetical protein; Provisional; Region: PRK06917
1195464005896	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464005897	inhibitor-cofactor binding pocket; inhibition site
1195464005898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464005899	catalytic residue [active]
1195464005900	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1195464005901	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1195464005902	acetylornithine deacetylase; Validated; Region: PRK06915
1195464005903	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
1195464005904	metal binding site [ion binding]; metal-binding site
1195464005905	dimer interface [polypeptide binding]; other site
1195464005906	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
1195464005907	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464005908	PAS fold; Region: PAS_4; pfam08448
1195464005909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464005910	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1195464005911	Walker A motif; other site
1195464005912	ATP binding site [chemical binding]; other site
1195464005913	Walker B motif; other site
1195464005914	arginine finger; other site
1195464005915	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1195464005916	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
1195464005917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464005918	FeS/SAM binding site; other site
1195464005919	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1195464005920	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
1195464005921	toxin interface [polypeptide binding]; other site
1195464005922	Zn binding site [ion binding]; other site
1195464005923	hypothetical protein; Provisional; Region: PRK13672
1195464005924	Protein of unknown function (DUF3930); Region: DUF3930; pfam13067
1195464005925	YozD-like protein; Region: YozD; pfam14162
1195464005926	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1195464005927	active site
1195464005928	ATP binding site [chemical binding]; other site
1195464005929	substrate binding site [chemical binding]; other site
1195464005930	activation loop (A-loop); other site
1195464005931	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1195464005932	SpoOM protein; Region: Spo0M; pfam07070
1195464005933	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1195464005934	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1195464005935	active site
1195464005936	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1195464005937	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1195464005938	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464005939	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1195464005940	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1195464005941	Int/Topo IB signature motif; other site
1195464005942	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1195464005943	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464005944	P-loop; other site
1195464005945	Magnesium ion binding site [ion binding]; other site
1195464005946	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464005947	Magnesium ion binding site [ion binding]; other site
1195464005948	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464005949	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464005950	non-specific DNA binding site [nucleotide binding]; other site
1195464005951	salt bridge; other site
1195464005952	sequence-specific DNA binding site [nucleotide binding]; other site
1195464005953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1195464005954	sequence-specific DNA binding site [nucleotide binding]; other site
1195464005955	salt bridge; other site
1195464005956	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464005957	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1195464005958	recombination and repair protein RecT; Reviewed; Region: recT; PRK09846
1195464005959	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1195464005960	hypothetical protein; Provisional; Region: PRK06921
1195464005961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464005962	ATP binding site [chemical binding]; other site
1195464005963	Walker A motif; other site
1195464005964	Walker B motif; other site
1195464005965	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
1195464005966	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464005967	hypothetical protein; Provisional; Region: PRK06764
1195464005968	FRG domain; Region: FRG; pfam08867
1195464005969	Protein of unknown function (DUF3908); Region: DUF3908; pfam13048
1195464005970	Phage terminase large subunit; Region: Terminase_3; cl12054
1195464005971	Terminase-like family; Region: Terminase_6; pfam03237
1195464005972	acetate--CoA ligase; Provisional; Region: PLN03052
1195464005973	H-type lectin domain; Region: H_lectin; pfam09458
1195464005974	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
1195464005975	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464005976	amidase catalytic site [active]
1195464005977	Zn binding residues [ion binding]; other site
1195464005978	substrate binding site [chemical binding]; other site
1195464005979	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464005980	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1195464005981	active site
1195464005982	metal binding site [ion binding]; metal-binding site
1195464005983	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
1195464005984	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1195464005985	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464005986	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464005987	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464005988	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464005989	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464005990	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1195464005991	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1195464005992	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1195464005993	active site
1195464005994	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
1195464005995	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1195464005996	YolD-like protein; Region: YolD; pfam08863
1195464005997	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1195464005998	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1195464005999	classical (c) SDRs; Region: SDR_c; cd05233
1195464006000	NAD(P) binding site [chemical binding]; other site
1195464006001	active site
1195464006002	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1195464006003	Transglycosylase; Region: Transgly; pfam00912
1195464006004	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1195464006005	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464006006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464006008	putative substrate translocation pore; other site
1195464006009	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1195464006010	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
1195464006011	dimer interface [polypeptide binding]; other site
1195464006012	Citrate synthase; Region: Citrate_synt; pfam00285
1195464006013	active site
1195464006014	coenzyme A binding site [chemical binding]; other site
1195464006015	citrylCoA binding site [chemical binding]; other site
1195464006016	oxalacetate/citrate binding site [chemical binding]; other site
1195464006017	catalytic triad [active]
1195464006018	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1195464006019	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1195464006020	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1195464006021	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1195464006022	tetramer interface [polypeptide binding]; other site
1195464006023	active site
1195464006024	Mg2+/Mn2+ binding site [ion binding]; other site
1195464006025	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1195464006026	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1195464006027	active site
1195464006028	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1195464006029	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1195464006030	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1195464006031	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1195464006032	tetrameric interface [polypeptide binding]; other site
1195464006033	NAD binding site [chemical binding]; other site
1195464006034	catalytic residues [active]
1195464006035	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1195464006036	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1195464006037	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1195464006038	substrate binding site [chemical binding]; other site
1195464006039	oxyanion hole (OAH) forming residues; other site
1195464006040	trimer interface [polypeptide binding]; other site
1195464006041	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1195464006042	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
1195464006043	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1195464006044	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1195464006045	active site
1195464006046	metal binding site [ion binding]; metal-binding site
1195464006047	DNA binding site [nucleotide binding]
1195464006048	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1195464006049	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1195464006050	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464006051	Walker A/P-loop; other site
1195464006052	ATP binding site [chemical binding]; other site
1195464006053	Q-loop/lid; other site
1195464006054	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1195464006055	ABC transporter signature motif; other site
1195464006056	Walker B; other site
1195464006057	D-loop; other site
1195464006058	H-loop/switch region; other site
1195464006059	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464006060	dimerization interface [polypeptide binding]; other site
1195464006061	putative DNA binding site [nucleotide binding]; other site
1195464006062	putative Zn2+ binding site [ion binding]; other site
1195464006063	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
1195464006064	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1195464006065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006066	putative substrate translocation pore; other site
1195464006067	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1195464006068	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1195464006069	putative NAD(P) binding site [chemical binding]; other site
1195464006070	active site
1195464006071	isochorismate synthase DhbC; Validated; Region: PRK06923
1195464006072	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1195464006073	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1195464006074	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1195464006075	acyl-activating enzyme (AAE) consensus motif; other site
1195464006076	active site
1195464006077	AMP binding site [chemical binding]; other site
1195464006078	substrate binding site [chemical binding]; other site
1195464006079	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1195464006080	hydrophobic substrate binding pocket; other site
1195464006081	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464006082	active site
1195464006083	conserved cis-peptide bond; other site
1195464006084	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1195464006085	Condensation domain; Region: Condensation; pfam00668
1195464006086	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1195464006087	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1195464006088	acyl-activating enzyme (AAE) consensus motif; other site
1195464006089	AMP binding site [chemical binding]; other site
1195464006090	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1195464006091	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1195464006092	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1195464006093	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1195464006094	acyl-activating enzyme (AAE) consensus motif; other site
1195464006095	AMP binding site [chemical binding]; other site
1195464006096	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1195464006097	MbtH-like protein; Region: MbtH; pfam03621
1195464006098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006099	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464006100	putative substrate translocation pore; other site
1195464006101	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1195464006102	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1195464006103	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1195464006104	IHF dimer interface [polypeptide binding]; other site
1195464006105	IHF - DNA interface [nucleotide binding]; other site
1195464006106	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
1195464006107	DinB family; Region: DinB; cl17821
1195464006108	DinB superfamily; Region: DinB_2; pfam12867
1195464006109	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1195464006110	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1195464006111	active site
1195464006112	catalytic triad [active]
1195464006113	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464006114	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1195464006115	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1195464006116	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464006117	RNA binding surface [nucleotide binding]; other site
1195464006118	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1195464006119	probable active site [active]
1195464006120	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
1195464006121	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1195464006122	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1195464006123	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1195464006124	active site
1195464006125	dimer interface [polypeptide binding]; other site
1195464006126	motif 1; other site
1195464006127	motif 2; other site
1195464006128	motif 3; other site
1195464006129	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1195464006130	anticodon binding site; other site
1195464006131	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464006132	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464006133	Walker A/P-loop; other site
1195464006134	ATP binding site [chemical binding]; other site
1195464006135	Q-loop/lid; other site
1195464006136	ABC transporter signature motif; other site
1195464006137	Walker B; other site
1195464006138	D-loop; other site
1195464006139	H-loop/switch region; other site
1195464006140	FtsX-like permease family; Region: FtsX; pfam02687
1195464006141	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464006142	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1195464006143	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464006144	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1195464006145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464006146	dimer interface [polypeptide binding]; other site
1195464006147	conserved gate region; other site
1195464006148	ABC-ATPase subunit interface; other site
1195464006149	pyruvate oxidase; Provisional; Region: PRK08611
1195464006150	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1195464006151	PYR/PP interface [polypeptide binding]; other site
1195464006152	dimer interface [polypeptide binding]; other site
1195464006153	tetramer interface [polypeptide binding]; other site
1195464006154	TPP binding site [chemical binding]; other site
1195464006155	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1195464006156	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1195464006157	TPP-binding site [chemical binding]; other site
1195464006158	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1195464006159	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464006160	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1195464006161	active site
1195464006162	dimerization interface [polypeptide binding]; other site
1195464006163	Protein of unknown function (DUF2441); Region: DUF2441; pfam10386
1195464006164	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1195464006165	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1195464006166	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464006167	ligand binding site [chemical binding]; other site
1195464006168	flexible hinge region; other site
1195464006169	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1195464006170	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1195464006171	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
1195464006172	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464006173	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464006174	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006175	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006176	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006177	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006178	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1195464006179	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1195464006180	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1195464006181	catalytic triad [active]
1195464006182	catalytic triad [active]
1195464006183	oxyanion hole [active]
1195464006184	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1195464006185	PAS domain S-box; Region: sensory_box; TIGR00229
1195464006186	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
1195464006187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464006188	putative active site [active]
1195464006189	heme pocket [chemical binding]; other site
1195464006190	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464006191	putative active site [active]
1195464006192	heme pocket [chemical binding]; other site
1195464006193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464006194	dimer interface [polypeptide binding]; other site
1195464006195	phosphorylation site [posttranslational modification]
1195464006196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006197	ATP binding site [chemical binding]; other site
1195464006198	Mg2+ binding site [ion binding]; other site
1195464006199	G-X-G motif; other site
1195464006200	Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495
1195464006201	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464006202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464006203	active site
1195464006204	phosphorylation site [posttranslational modification]
1195464006205	intermolecular recognition site; other site
1195464006206	dimerization interface [polypeptide binding]; other site
1195464006207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464006208	DNA binding site [nucleotide binding]
1195464006209	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464006210	HAMP domain; Region: HAMP; pfam00672
1195464006211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464006212	dimer interface [polypeptide binding]; other site
1195464006213	phosphorylation site [posttranslational modification]
1195464006214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006215	ATP binding site [chemical binding]; other site
1195464006216	Mg2+ binding site [ion binding]; other site
1195464006217	G-X-G motif; other site
1195464006218	Electron transfer DM13; Region: DM13; pfam10517
1195464006219	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1195464006220	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1195464006221	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1195464006222	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1195464006223	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464006224	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464006225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464006226	MMPL family; Region: MMPL; pfam03176
1195464006227	MMPL family; Region: MMPL; pfam03176
1195464006228	Protein of unknown function (DUF4021); Region: DUF4021; pfam13213
1195464006229	Chloramphenicol acetyltransferase; Region: CAT; cl02008
1195464006230	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464006231	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006232	Coenzyme A binding pocket [chemical binding]; other site
1195464006233	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1195464006234	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1195464006235	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1195464006236	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006237	Coenzyme A binding pocket [chemical binding]; other site
1195464006238	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464006239	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1195464006240	EamA-like transporter family; Region: EamA; pfam00892
1195464006241	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1195464006242	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464006243	non-specific DNA binding site [nucleotide binding]; other site
1195464006244	salt bridge; other site
1195464006245	sequence-specific DNA binding site [nucleotide binding]; other site
1195464006246	Cupin domain; Region: Cupin_2; pfam07883
1195464006247	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1195464006248	protoporphyrinogen oxidase; Provisional; Region: PRK12416
1195464006249	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464006250	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464006251	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464006252	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464006253	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1195464006254	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1195464006255	DNA-binding site [nucleotide binding]; DNA binding site
1195464006256	RNA-binding motif; other site
1195464006257	CAAX protease self-immunity; Region: Abi; pfam02517
1195464006258	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
1195464006259	AAA domain; Region: AAA_18; pfam13238
1195464006260	active site
1195464006261	hypothetical protein; Provisional; Region: PRK06770
1195464006262	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464006263	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464006264	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464006265	dimerization interface [polypeptide binding]; other site
1195464006266	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728
1195464006267	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1195464006268	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1195464006269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464006270	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464006271	dimerization interface [polypeptide binding]; other site
1195464006272	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1195464006273	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464006274	inhibitor-cofactor binding pocket; inhibition site
1195464006275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464006276	catalytic residue [active]
1195464006277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1195464006278	MOSC domain; Region: MOSC; pfam03473
1195464006279	3-alpha domain; Region: 3-alpha; pfam03475
1195464006280	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006281	Coenzyme A binding pocket [chemical binding]; other site
1195464006282	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1195464006283	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464006284	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464006285	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464006286	Walker A/P-loop; other site
1195464006287	ATP binding site [chemical binding]; other site
1195464006288	Q-loop/lid; other site
1195464006289	ABC transporter signature motif; other site
1195464006290	Walker B; other site
1195464006291	D-loop; other site
1195464006292	H-loop/switch region; other site
1195464006293	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464006294	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464006295	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1195464006296	Walker A/P-loop; other site
1195464006297	ATP binding site [chemical binding]; other site
1195464006298	Q-loop/lid; other site
1195464006299	ABC transporter signature motif; other site
1195464006300	Walker B; other site
1195464006301	D-loop; other site
1195464006302	H-loop/switch region; other site
1195464006303	LysE type translocator; Region: LysE; cl00565
1195464006304	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1195464006305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464006306	non-specific DNA binding site [nucleotide binding]; other site
1195464006307	salt bridge; other site
1195464006308	sequence-specific DNA binding site [nucleotide binding]; other site
1195464006309	Cupin domain; Region: Cupin_2; pfam07883
1195464006310	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
1195464006311	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
1195464006312	BclB C-terminal domain; Region: exospore_TM; TIGR03721
1195464006313	Cupin; Region: Cupin_1; smart00835
1195464006314	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1195464006315	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464006316	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1195464006317	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464006318	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1195464006319	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1195464006320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006321	S-adenosylmethionine binding site [chemical binding]; other site
1195464006322	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1195464006323	Domain of unknown function (DUF3974); Region: DUF3974; pfam13120
1195464006324	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1195464006325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1195464006326	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1195464006327	active site
1195464006328	P-loop; other site
1195464006329	phosphorylation site [posttranslational modification]
1195464006330	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1195464006331	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1195464006332	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1195464006333	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1195464006334	nucleotide binding site [chemical binding]; other site
1195464006335	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1195464006336	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1195464006337	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1195464006338	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464006339	catalytic residue [active]
1195464006340	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1195464006341	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464006342	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1195464006343	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1195464006344	ATP binding site [chemical binding]; other site
1195464006345	Mg++ binding site [ion binding]; other site
1195464006346	motif III; other site
1195464006347	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464006348	nucleotide binding region [chemical binding]; other site
1195464006349	ATP-binding site [chemical binding]; other site
1195464006350	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464006351	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006352	S-adenosylmethionine binding site [chemical binding]; other site
1195464006353	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1195464006354	dimer interface [polypeptide binding]; other site
1195464006355	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464006356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006357	S-adenosylmethionine binding site [chemical binding]; other site
1195464006358	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1195464006359	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1195464006360	dimer interface [polypeptide binding]; other site
1195464006361	PYR/PP interface [polypeptide binding]; other site
1195464006362	TPP binding site [chemical binding]; other site
1195464006363	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1195464006364	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1195464006365	TPP-binding site [chemical binding]; other site
1195464006366	dimer interface [polypeptide binding]; other site
1195464006367	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464006368	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464006369	putative DNA binding site [nucleotide binding]; other site
1195464006370	putative Zn2+ binding site [ion binding]; other site
1195464006371	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464006372	catalytic core [active]
1195464006373	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464006374	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
1195464006375	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464006376	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1195464006377	metal binding site [ion binding]; metal-binding site
1195464006378	dimer interface [polypeptide binding]; other site
1195464006379	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1195464006380	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
1195464006381	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1195464006382	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1195464006383	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464006384	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464006385	DNA binding residues [nucleotide binding]
1195464006386	dimerization interface [polypeptide binding]; other site
1195464006387	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464006388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464006389	non-specific DNA binding site [nucleotide binding]; other site
1195464006390	salt bridge; other site
1195464006391	sequence-specific DNA binding site [nucleotide binding]; other site
1195464006392	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464006393	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1195464006394	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464006395	hypothetical protein; Provisional; Region: PRK10621
1195464006396	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464006397	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1195464006398	trimer interface [polypeptide binding]; other site
1195464006399	active site
1195464006400	CoA binding site [chemical binding]; other site
1195464006401	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1195464006402	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464006403	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1195464006404	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1195464006405	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1195464006406	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1195464006407	active site
1195464006408	catalytic triad [active]
1195464006409	oxyanion hole [active]
1195464006410	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1195464006411	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464006412	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1195464006413	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464006414	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1195464006415	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464006416	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464006417	DNA binding residues [nucleotide binding]
1195464006418	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1195464006419	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464006420	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464006421	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464006422	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464006423	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464006424	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464006425	beta-lactamase TEM; Provisional; Region: PRK15442
1195464006426	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1195464006427	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006428	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006429	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1195464006430	Peptidase M60-like family; Region: M60-like; pfam13402
1195464006431	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464006432	Spore germination protein; Region: Spore_permease; cl17796
1195464006433	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464006434	Fic family protein [Function unknown]; Region: COG3177
1195464006435	Fic/DOC family; Region: Fic; pfam02661
1195464006436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
1195464006437	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1195464006438	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464006439	Interdomain contacts; other site
1195464006440	Cytokine receptor motif; other site
1195464006441	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464006442	Interdomain contacts; other site
1195464006443	Cytokine receptor motif; other site
1195464006444	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1195464006445	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
1195464006446	active site
1195464006447	catalytic site [active]
1195464006448	putative metal binding site [ion binding]; other site
1195464006449	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1195464006450	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464006451	putative active site [active]
1195464006452	putative metal binding site [ion binding]; other site
1195464006453	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464006454	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1195464006455	Walker A/P-loop; other site
1195464006456	ATP binding site [chemical binding]; other site
1195464006457	Q-loop/lid; other site
1195464006458	ABC transporter signature motif; other site
1195464006459	Walker B; other site
1195464006460	D-loop; other site
1195464006461	H-loop/switch region; other site
1195464006462	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1195464006463	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1195464006464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464006465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464006466	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1195464006467	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1195464006468	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1195464006469	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1195464006470	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1195464006471	FAD binding site [chemical binding]; other site
1195464006472	homotetramer interface [polypeptide binding]; other site
1195464006473	substrate binding pocket [chemical binding]; other site
1195464006474	catalytic base [active]
1195464006475	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
1195464006476	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1195464006477	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1195464006478	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1195464006479	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1195464006480	carboxyltransferase (CT) interaction site; other site
1195464006481	biotinylation site [posttranslational modification]; other site
1195464006482	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1195464006483	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1195464006484	active site
1195464006485	catalytic residues [active]
1195464006486	metal binding site [ion binding]; metal-binding site
1195464006487	enoyl-CoA hydratase; Provisional; Region: PRK07657
1195464006488	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1195464006489	substrate binding site [chemical binding]; other site
1195464006490	oxyanion hole (OAH) forming residues; other site
1195464006491	trimer interface [polypeptide binding]; other site
1195464006492	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1195464006493	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1195464006494	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1195464006495	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1195464006496	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
1195464006497	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
1195464006498	acyl-activating enzyme (AAE) consensus motif; other site
1195464006499	putative AMP binding site [chemical binding]; other site
1195464006500	putative active site [active]
1195464006501	putative CoA binding site [chemical binding]; other site
1195464006502	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1195464006503	Septum formation initiator; Region: DivIC; pfam04977
1195464006504	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464006505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006506	Coenzyme A binding pocket [chemical binding]; other site
1195464006507	hypothetical protein; Provisional; Region: PRK08233
1195464006508	AAA domain; Region: AAA_18; pfam13238
1195464006509	active site
1195464006510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464006511	PGAP1-like protein; Region: PGAP1; pfam07819
1195464006512	DinB family; Region: DinB; cl17821
1195464006513	DinB superfamily; Region: DinB_2; pfam12867
1195464006514	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1195464006515	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464006516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464006517	dimer interface [polypeptide binding]; other site
1195464006518	phosphorylation site [posttranslational modification]
1195464006519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006520	ATP binding site [chemical binding]; other site
1195464006521	Mg2+ binding site [ion binding]; other site
1195464006522	G-X-G motif; other site
1195464006523	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464006524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464006525	active site
1195464006526	phosphorylation site [posttranslational modification]
1195464006527	intermolecular recognition site; other site
1195464006528	dimerization interface [polypeptide binding]; other site
1195464006529	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464006530	DNA binding site [nucleotide binding]
1195464006531	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
1195464006532	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
1195464006533	S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714
1195464006534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006535	Coenzyme A binding pocket [chemical binding]; other site
1195464006536	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1195464006537	Coenzyme A binding pocket [chemical binding]; other site
1195464006538	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464006539	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464006540	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1195464006541	active site
1195464006542	Zn binding site [ion binding]; other site
1195464006543	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1195464006544	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1195464006545	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1195464006546	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1195464006547	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464006548	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464006549	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1195464006550	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464006551	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1195464006552	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1195464006553	active site
1195464006554	catalytic site [active]
1195464006555	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1195464006556	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1195464006557	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464006558	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464006559	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464006560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1195464006561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1195464006562	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
1195464006563	putative hydrophobic ligand binding site [chemical binding]; other site
1195464006564	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464006565	AAA domain; Region: AAA_21; pfam13304
1195464006566	Walker A/P-loop; other site
1195464006567	ATP binding site [chemical binding]; other site
1195464006568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464006569	ABC transporter signature motif; other site
1195464006570	Walker B; other site
1195464006571	D-loop; other site
1195464006572	H-loop/switch region; other site
1195464006573	ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238
1195464006574	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1195464006575	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
1195464006576	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464006577	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464006578	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
1195464006579	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464006580	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464006581	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1195464006582	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464006583	drug binding residues [chemical binding]; other site
1195464006584	dimer interface [polypeptide binding]; other site
1195464006585	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1195464006586	short chain dehydrogenase; Provisional; Region: PRK07041
1195464006587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464006588	NAD(P) binding site [chemical binding]; other site
1195464006589	active site
1195464006590	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464006591	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1195464006592	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464006593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006594	S-adenosylmethionine binding site [chemical binding]; other site
1195464006595	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1195464006596	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464006597	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1195464006598	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464006599	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464006600	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1195464006601	active site
1195464006602	substrate binding site [chemical binding]; other site
1195464006603	ATP binding site [chemical binding]; other site
1195464006604	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464006605	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1195464006606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464006607	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
1195464006608	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
1195464006609	active site
1195464006610	Zn binding site [ion binding]; other site
1195464006611	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464006612	EamA-like transporter family; Region: EamA; pfam00892
1195464006613	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464006614	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464006615	DNA-binding site [nucleotide binding]; DNA binding site
1195464006616	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464006617	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464006618	homodimer interface [polypeptide binding]; other site
1195464006619	catalytic residue [active]
1195464006620	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464006621	extended (e) SDRs; Region: SDR_e; cd08946
1195464006622	NAD(P) binding site [chemical binding]; other site
1195464006623	active site
1195464006624	substrate binding site [chemical binding]; other site
1195464006625	Predicted membrane protein [Function unknown]; Region: COG2323
1195464006626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006627	S-adenosylmethionine binding site [chemical binding]; other site
1195464006628	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464006629	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1195464006630	conserved cys residue [active]
1195464006631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006632	S-adenosylmethionine binding site [chemical binding]; other site
1195464006633	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1195464006634	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
1195464006635	catalytic core domain of  class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674
1195464006636	active site
1195464006637	HIGH motif; other site
1195464006638	KMSKS motif; other site
1195464006639	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1195464006640	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1195464006641	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464006642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464006643	active site
1195464006644	phosphorylation site [posttranslational modification]
1195464006645	intermolecular recognition site; other site
1195464006646	dimerization interface [polypeptide binding]; other site
1195464006647	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464006648	DNA binding site [nucleotide binding]
1195464006649	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464006650	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1195464006651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006652	ATP binding site [chemical binding]; other site
1195464006653	Mg2+ binding site [ion binding]; other site
1195464006654	G-X-G motif; other site
1195464006655	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1195464006656	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464006657	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1195464006658	dimerization interface [polypeptide binding]; other site
1195464006659	substrate binding pocket [chemical binding]; other site
1195464006660	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464006661	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464006662	active site
1195464006663	catalytic tetrad [active]
1195464006664	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464006665	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464006666	ABC transporter; Region: ABC_tran_2; pfam12848
1195464006667	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464006668	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464006669	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464006670	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464006671	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464006672	Walker A/P-loop; other site
1195464006673	ATP binding site [chemical binding]; other site
1195464006674	Q-loop/lid; other site
1195464006675	ABC transporter signature motif; other site
1195464006676	Walker B; other site
1195464006677	D-loop; other site
1195464006678	H-loop/switch region; other site
1195464006679	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464006680	FtsX-like permease family; Region: FtsX; pfam02687
1195464006681	hypothetical protein; Provisional; Region: PRK06760
1195464006682	Protein of unknown function (DUF3914); Region: DUF3914; pfam13053
1195464006683	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1195464006684	homoserine dehydrogenase; Validated; Region: PRK06813
1195464006685	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1195464006686	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1195464006687	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464006688	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464006689	DNA-binding site [nucleotide binding]; DNA binding site
1195464006690	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464006691	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464006692	homodimer interface [polypeptide binding]; other site
1195464006693	catalytic residue [active]
1195464006694	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1195464006695	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1195464006696	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1195464006697	Putative transcription activator [Transcription]; Region: TenA; COG0819
1195464006698	probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601
1195464006699	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
1195464006700	active site
1195464006701	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464006702	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1195464006703	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1195464006704	Protein of unknown function (DUF3962); Region: DUF3962; pfam13111
1195464006705	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
1195464006706	Protein of unknown function (DUF3959); Region: DUF3959; pfam13105
1195464006707	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
1195464006708	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1195464006709	Protein of unknown function; Region: DUF3658; pfam12395
1195464006710	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1195464006711	Cytochrome P450; Region: p450; cl12078
1195464006712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006713	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464006714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006715	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1195464006716	trimer interface [polypeptide binding]; other site
1195464006717	active site
1195464006718	substrate binding site [chemical binding]; other site
1195464006719	CoA binding site [chemical binding]; other site
1195464006720	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1195464006721	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464006722	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464006723	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1195464006724	Cytochrome P450; Region: p450; cl12078
1195464006725	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1195464006726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464006727	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464006728	active site
1195464006729	motif I; other site
1195464006730	motif II; other site
1195464006731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464006732	PAS domain S-box; Region: sensory_box; TIGR00229
1195464006733	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464006734	putative active site [active]
1195464006735	heme pocket [chemical binding]; other site
1195464006736	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1195464006737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464006738	dimer interface [polypeptide binding]; other site
1195464006739	phosphorylation site [posttranslational modification]
1195464006740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006741	ATP binding site [chemical binding]; other site
1195464006742	Mg2+ binding site [ion binding]; other site
1195464006743	G-X-G motif; other site
1195464006744	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464006745	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464006746	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464006747	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1195464006748	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464006749	Catalytic site [active]
1195464006750	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1195464006751	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1195464006752	active site
1195464006753	TDP-binding site; other site
1195464006754	acceptor substrate-binding pocket; other site
1195464006755	homodimer interface [polypeptide binding]; other site
1195464006756	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1195464006757	aspartate racemase; Region: asp_race; TIGR00035
1195464006758	hypothetical protein; Provisional; Region: PRK13661
1195464006759	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464006760	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1195464006761	Walker A/P-loop; other site
1195464006762	ATP binding site [chemical binding]; other site
1195464006763	Q-loop/lid; other site
1195464006764	ABC transporter signature motif; other site
1195464006765	Walker B; other site
1195464006766	D-loop; other site
1195464006767	H-loop/switch region; other site
1195464006768	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1195464006769	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464006770	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1195464006771	Walker A/P-loop; other site
1195464006772	ATP binding site [chemical binding]; other site
1195464006773	Q-loop/lid; other site
1195464006774	ABC transporter signature motif; other site
1195464006775	Walker B; other site
1195464006776	D-loop; other site
1195464006777	H-loop/switch region; other site
1195464006778	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1195464006779	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1195464006780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464006781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464006782	dimer interface [polypeptide binding]; other site
1195464006783	phosphorylation site [posttranslational modification]
1195464006784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006785	ATP binding site [chemical binding]; other site
1195464006786	Mg2+ binding site [ion binding]; other site
1195464006787	G-X-G motif; other site
1195464006788	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1195464006789	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1195464006790	active site
1195464006791	ATP binding site [chemical binding]; other site
1195464006792	substrate binding site [chemical binding]; other site
1195464006793	activation loop (A-loop); other site
1195464006794	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1195464006795	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464006796	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1195464006797	NAD(P) binding site [chemical binding]; other site
1195464006798	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1195464006799	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1195464006800	active site
1195464006801	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464006802	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464006803	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464006804	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1195464006805	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1195464006806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006807	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464006808	putative substrate translocation pore; other site
1195464006809	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464006810	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464006811	VanZ like family; Region: VanZ; pfam04892
1195464006812	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
1195464006813	EDD domain protein, DegV family; Region: DegV; TIGR00762
1195464006814	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1195464006815	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464006816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464006817	non-specific DNA binding site [nucleotide binding]; other site
1195464006818	salt bridge; other site
1195464006819	sequence-specific DNA binding site [nucleotide binding]; other site
1195464006820	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1195464006821	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464006822	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777
1195464006823	DNA binding residues [nucleotide binding]
1195464006824	putative dimer interface [polypeptide binding]; other site
1195464006825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464006826	S-adenosylmethionine binding site [chemical binding]; other site
1195464006827	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464006828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006830	Coenzyme A binding pocket [chemical binding]; other site
1195464006831	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1195464006832	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1195464006833	active site
1195464006834	catalytic site [active]
1195464006835	metal binding site [ion binding]; metal-binding site
1195464006836	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
1195464006837	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464006838	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464006839	DNA-binding site [nucleotide binding]; DNA binding site
1195464006840	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464006841	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464006842	homodimer interface [polypeptide binding]; other site
1195464006843	catalytic residue [active]
1195464006844	EamA-like transporter family; Region: EamA; pfam00892
1195464006845	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464006846	EamA-like transporter family; Region: EamA; pfam00892
1195464006847	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1195464006848	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1195464006849	active site
1195464006850	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464006851	Coenzyme A binding pocket [chemical binding]; other site
1195464006852	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464006853	nudix motif; other site
1195464006854	probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601
1195464006855	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464006856	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464006857	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1195464006858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464006859	putative substrate translocation pore; other site
1195464006860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464006861	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006862	Coenzyme A binding pocket [chemical binding]; other site
1195464006863	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1195464006864	nudix motif; other site
1195464006865	DNA polymerase III subunit beta; Validated; Region: PRK06673
1195464006866	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1195464006867	putative DNA binding surface [nucleotide binding]; other site
1195464006868	dimer interface [polypeptide binding]; other site
1195464006869	beta-clamp/clamp loader binding surface; other site
1195464006870	beta-clamp/translesion DNA polymerase binding surface; other site
1195464006871	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464006872	nudix motif; other site
1195464006873	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464006874	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1195464006875	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1195464006876	Homeodomain-like domain; Region: HTH_23; cl17451
1195464006877	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1195464006878	homotrimer interaction site [polypeptide binding]; other site
1195464006879	putative active site [active]
1195464006880	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1195464006881	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1195464006882	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
1195464006883	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1195464006884	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1195464006885	YxiJ-like protein; Region: YxiJ; pfam14176
1195464006886	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1195464006887	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1195464006888	active site
1195464006889	nucleophile elbow; other site
1195464006890	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1195464006891	pentamer interface [polypeptide binding]; other site
1195464006892	dodecaamer interface [polypeptide binding]; other site
1195464006893	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464006894	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006895	Coenzyme A binding pocket [chemical binding]; other site
1195464006896	metal-dependent hydrolase; Provisional; Region: PRK13291
1195464006897	DinB superfamily; Region: DinB_2; pfam12867
1195464006898	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464006899	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464006900	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1195464006901	Bacitracin resistance protein BacA; Region: BacA; pfam02673
1195464006902	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1195464006903	GIY-YIG motif/motif A; other site
1195464006904	active site
1195464006905	catalytic site [active]
1195464006906	putative DNA binding site [nucleotide binding]; other site
1195464006907	metal binding site [ion binding]; metal-binding site
1195464006908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006909	Coenzyme A binding pocket [chemical binding]; other site
1195464006910	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1195464006911	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1195464006912	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464006913	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1195464006914	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1195464006915	MepB protein; Region: MepB; pfam08877
1195464006916	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
1195464006917	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1195464006918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464006919	motif II; other site
1195464006920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464006921	Response regulator receiver domain; Region: Response_reg; pfam00072
1195464006922	active site
1195464006923	phosphorylation site [posttranslational modification]
1195464006924	intermolecular recognition site; other site
1195464006925	dimerization interface [polypeptide binding]; other site
1195464006926	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464006927	DNA binding site [nucleotide binding]
1195464006928	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1195464006929	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464006930	dimerization interface [polypeptide binding]; other site
1195464006931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464006932	dimer interface [polypeptide binding]; other site
1195464006933	phosphorylation site [posttranslational modification]
1195464006934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464006935	ATP binding site [chemical binding]; other site
1195464006936	Mg2+ binding site [ion binding]; other site
1195464006937	G-X-G motif; other site
1195464006938	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1195464006939	nudix motif; other site
1195464006940	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1195464006941	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464006942	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464006943	Walker A/P-loop; other site
1195464006944	ATP binding site [chemical binding]; other site
1195464006945	Q-loop/lid; other site
1195464006946	ABC transporter signature motif; other site
1195464006947	Walker B; other site
1195464006948	D-loop; other site
1195464006949	H-loop/switch region; other site
1195464006950	FtsX-like permease family; Region: FtsX; pfam02687
1195464006951	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464006952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464006953	Coenzyme A binding pocket [chemical binding]; other site
1195464006954	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464006955	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1195464006956	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1195464006957	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464006958	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1195464006959	carbohydrate binding site [chemical binding]; other site
1195464006960	pullulanase, type I; Region: pulA_typeI; TIGR02104
1195464006961	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1195464006962	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1195464006963	Ca binding site [ion binding]; other site
1195464006964	active site
1195464006965	catalytic site [active]
1195464006966	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1195464006967	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464006968	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464006969	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1195464006970	active site
1195464006971	Zn binding site [ion binding]; other site
1195464006972	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
1195464006973	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1195464006974	active site
1195464006975	metal binding site [ion binding]; metal-binding site
1195464006976	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1195464006977	DinB superfamily; Region: DinB_2; pfam12867
1195464006978	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
1195464006979	SecY translocase; Region: SecY; pfam00344
1195464006980	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1195464006981	EamA-like transporter family; Region: EamA; pfam00892
1195464006982	EamA-like transporter family; Region: EamA; pfam00892
1195464006983	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464006984	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464006985	DNA-binding site [nucleotide binding]; DNA binding site
1195464006986	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464006987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464006988	homodimer interface [polypeptide binding]; other site
1195464006989	catalytic residue [active]
1195464006990	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464006991	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1195464006992	putative NAD(P) binding site [chemical binding]; other site
1195464006993	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464006994	TAP-like protein; Region: Abhydrolase_4; pfam08386
1195464006995	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1195464006996	Mg binding site [ion binding]; other site
1195464006997	nucleotide binding site [chemical binding]; other site
1195464006998	putative protofilament interface [polypeptide binding]; other site
1195464006999	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1195464007000	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464007001	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1195464007002	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1195464007003	germination protein YpeB; Region: spore_YpeB; TIGR02889
1195464007004	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1195464007005	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1195464007006	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1195464007007	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1195464007008	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464007009	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464007010	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
1195464007011	arylformamidase; Region: trp_arylform; TIGR03035
1195464007012	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1195464007013	kynureninase; Region: kynureninase; TIGR01814
1195464007014	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464007015	catalytic residue [active]
1195464007016	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464007017	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464007018	Protein of unknown function (DUF3977); Region: DUF3977; pfam13122
1195464007019	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1195464007020	GAF domain; Region: GAF; pfam01590
1195464007021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464007022	Walker A motif; other site
1195464007023	ATP binding site [chemical binding]; other site
1195464007024	Walker B motif; other site
1195464007025	arginine finger; other site
1195464007026	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1195464007027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1195464007028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007029	Coenzyme A binding pocket [chemical binding]; other site
1195464007030	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1195464007031	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1195464007032	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1195464007033	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
1195464007034	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
1195464007035	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464007036	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464007037	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1195464007038	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1195464007039	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1195464007040	E3 interaction surface; other site
1195464007041	lipoyl attachment site [posttranslational modification]; other site
1195464007042	e3 binding domain; Region: E3_binding; pfam02817
1195464007043	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1195464007044	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1195464007045	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1195464007046	alpha subunit interface [polypeptide binding]; other site
1195464007047	TPP binding site [chemical binding]; other site
1195464007048	heterodimer interface [polypeptide binding]; other site
1195464007049	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464007050	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1195464007051	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1195464007052	tetramer interface [polypeptide binding]; other site
1195464007053	TPP-binding site [chemical binding]; other site
1195464007054	heterodimer interface [polypeptide binding]; other site
1195464007055	phosphorylation loop region [posttranslational modification]
1195464007056	DinB superfamily; Region: DinB_2; pfam12867
1195464007057	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1195464007058	short chain dehydrogenase; Provisional; Region: PRK06914
1195464007059	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1195464007060	NADP binding site [chemical binding]; other site
1195464007061	active site
1195464007062	steroid binding site; other site
1195464007063	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
1195464007064	Protein phosphatase 2C; Region: PP2C_2; pfam13672
1195464007065	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1195464007066	nucleotide binding site/active site [active]
1195464007067	HIT family signature motif; other site
1195464007068	catalytic residue [active]
1195464007069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464007070	dimer interface [polypeptide binding]; other site
1195464007071	conserved gate region; other site
1195464007072	putative PBP binding loops; other site
1195464007073	ABC-ATPase subunit interface; other site
1195464007074	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1195464007075	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1195464007076	Walker A/P-loop; other site
1195464007077	ATP binding site [chemical binding]; other site
1195464007078	Q-loop/lid; other site
1195464007079	ABC transporter signature motif; other site
1195464007080	Walker B; other site
1195464007081	D-loop; other site
1195464007082	H-loop/switch region; other site
1195464007083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1195464007084	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1195464007085	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1195464007086	Clp protease; Region: CLP_protease; pfam00574
1195464007087	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1195464007088	oligomer interface [polypeptide binding]; other site
1195464007089	active site residues [active]
1195464007090	RNA polymerase factor sigma-70; Validated; Region: PRK06704
1195464007091	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464007092	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1195464007093	DNA binding residues [nucleotide binding]
1195464007094	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1195464007095	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1195464007096	catalytic loop [active]
1195464007097	iron binding site [ion binding]; other site
1195464007098	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1195464007099	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464007100	active site
1195464007101	dimer interface [polypeptide binding]; other site
1195464007102	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007103	Coenzyme A binding pocket [chemical binding]; other site
1195464007104	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1195464007105	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464007106	Interdomain contacts; other site
1195464007107	Cytokine receptor motif; other site
1195464007108	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464007109	Interdomain contacts; other site
1195464007110	Cytokine receptor motif; other site
1195464007111	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
1195464007112	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1195464007113	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1195464007114	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1195464007115	active site
1195464007116	TDP-binding site; other site
1195464007117	acceptor substrate-binding pocket; other site
1195464007118	homodimer interface [polypeptide binding]; other site
1195464007119	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1195464007120	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1195464007121	topology modulation protein; Reviewed; Region: PRK08118
1195464007122	AAA domain; Region: AAA_17; pfam13207
1195464007123	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464007124	active site
1195464007125	ATP binding site [chemical binding]; other site
1195464007126	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464007127	substrate binding site [chemical binding]; other site
1195464007128	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1195464007129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464007130	S-adenosylmethionine binding site [chemical binding]; other site
1195464007131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1195464007132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007133	Coenzyme A binding pocket [chemical binding]; other site
1195464007134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007135	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464007136	Coenzyme A binding pocket [chemical binding]; other site
1195464007137	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1195464007138	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1195464007139	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007140	Coenzyme A binding pocket [chemical binding]; other site
1195464007141	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464007142	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464007143	Protein of unknown function (DUF952); Region: DUF952; pfam06108
1195464007144	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
1195464007145	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1195464007146	Part of AAA domain; Region: AAA_19; pfam13245
1195464007147	Family description; Region: UvrD_C_2; pfam13538
1195464007148	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1195464007149	putative active site pocket [active]
1195464007150	dimerization interface [polypeptide binding]; other site
1195464007151	putative catalytic residue [active]
1195464007152	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1195464007153	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464007154	ATP binding site [chemical binding]; other site
1195464007155	putative Mg++ binding site [ion binding]; other site
1195464007156	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464007157	nucleotide binding region [chemical binding]; other site
1195464007158	ATP-binding site [chemical binding]; other site
1195464007159	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1195464007160	HRDC domain; Region: HRDC; pfam00570
1195464007161	Protein of unknown function (DUF4017); Region: DUF4017; pfam13209
1195464007162	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1195464007163	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1195464007164	DHHA2 domain; Region: DHHA2; pfam02833
1195464007165	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1195464007166	DinB family; Region: DinB; cl17821
1195464007167	DinB superfamily; Region: DinB_2; pfam12867
1195464007168	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464007169	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007170	Coenzyme A binding pocket [chemical binding]; other site
1195464007171	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464007172	Zn2+ binding site [ion binding]; other site
1195464007173	Mg2+ binding site [ion binding]; other site
1195464007174	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1195464007175	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464007176	amino acid carrier protein; Region: agcS; TIGR00835
1195464007177	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1195464007178	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1195464007179	NAD(P) binding site [chemical binding]; other site
1195464007180	catalytic residues [active]
1195464007181	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1195464007182	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1195464007183	inhibitor site; inhibition site
1195464007184	active site
1195464007185	dimer interface [polypeptide binding]; other site
1195464007186	catalytic residue [active]
1195464007187	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1195464007188	Proline racemase; Region: Pro_racemase; pfam05544
1195464007189	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1195464007190	Proline racemase; Region: Pro_racemase; pfam05544
1195464007191	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1195464007192	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1195464007193	PAS domain; Region: PAS; smart00091
1195464007194	PAS domain; Region: PAS_10; pfam13596
1195464007195	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1195464007196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464007197	Walker A motif; other site
1195464007198	ATP binding site [chemical binding]; other site
1195464007199	Walker B motif; other site
1195464007200	arginine finger; other site
1195464007201	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1195464007202	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1195464007203	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1195464007204	catalytic loop [active]
1195464007205	iron binding site [ion binding]; other site
1195464007206	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1195464007207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464007208	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
1195464007209	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1195464007210	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1195464007211	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464007212	active site
1195464007213	metal binding site [ion binding]; metal-binding site
1195464007214	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1195464007215	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464007216	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1195464007217	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464007218	Zn2+ binding site [ion binding]; other site
1195464007219	Mg2+ binding site [ion binding]; other site
1195464007220	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464007221	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464007222	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1195464007223	DltD N-terminal region; Region: DltD_N; pfam04915
1195464007224	DltD central region; Region: DltD_M; pfam04918
1195464007225	DltD C-terminal region; Region: DltD_C; pfam04914
1195464007226	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464007227	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464007228	peptide binding site [polypeptide binding]; other site
1195464007229	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464007230	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464007231	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1195464007232	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1195464007233	active site
1195464007234	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
1195464007235	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1195464007236	Septum formation initiator; Region: DivIC; pfam04977
1195464007237	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
1195464007238	AAA domain; Region: AAA_17; pfam13207
1195464007239	AAA domain; Region: AAA_18; pfam13238
1195464007240	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464007241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464007242	S-adenosylmethionine binding site [chemical binding]; other site
1195464007243	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
1195464007244	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1195464007245	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464007246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464007247	dimerization interface [polypeptide binding]; other site
1195464007248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464007249	dimer interface [polypeptide binding]; other site
1195464007250	phosphorylation site [posttranslational modification]
1195464007251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464007252	ATP binding site [chemical binding]; other site
1195464007253	Mg2+ binding site [ion binding]; other site
1195464007254	G-X-G motif; other site
1195464007255	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464007256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464007257	active site
1195464007258	phosphorylation site [posttranslational modification]
1195464007259	intermolecular recognition site; other site
1195464007260	dimerization interface [polypeptide binding]; other site
1195464007261	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464007262	DNA binding site [nucleotide binding]
1195464007263	DinB superfamily; Region: DinB_2; pfam12867
1195464007264	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1195464007265	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464007266	motif II; other site
1195464007267	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1195464007268	Zn binding site [ion binding]; other site
1195464007269	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1195464007270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007271	Coenzyme A binding pocket [chemical binding]; other site
1195464007272	EDD domain protein, DegV family; Region: DegV; TIGR00762
1195464007273	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1195464007274	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007275	Coenzyme A binding pocket [chemical binding]; other site
1195464007276	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1195464007277	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1195464007278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007279	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1195464007280	putative substrate translocation pore; other site
1195464007281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007282	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1195464007283	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1195464007284	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
1195464007285	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1195464007286	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1195464007287	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1195464007288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007289	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464007290	putative substrate translocation pore; other site
1195464007291	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
1195464007292	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1195464007293	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1195464007294	active site
1195464007295	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
1195464007296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464007297	S-adenosylmethionine binding site [chemical binding]; other site
1195464007298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007299	putative substrate translocation pore; other site
1195464007300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464007301	aspartate aminotransferase; Provisional; Region: PRK07681
1195464007302	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464007303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464007304	homodimer interface [polypeptide binding]; other site
1195464007305	catalytic residue [active]
1195464007306	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1195464007307	pantothenate kinase; Provisional; Region: PRK13317
1195464007308	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
1195464007309	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1195464007310	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1195464007311	Protein of unknown function (DUF4052); Region: DUF4052; pfam13261
1195464007312	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464007313	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464007314	Walker A/P-loop; other site
1195464007315	ATP binding site [chemical binding]; other site
1195464007316	Q-loop/lid; other site
1195464007317	ABC transporter signature motif; other site
1195464007318	Walker B; other site
1195464007319	D-loop; other site
1195464007320	H-loop/switch region; other site
1195464007321	Predicted transcriptional regulators [Transcription]; Region: COG1725
1195464007322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464007323	DNA-binding site [nucleotide binding]; DNA binding site
1195464007324	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
1195464007325	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734
1195464007326	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
1195464007327	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
1195464007328	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
1195464007329	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
1195464007330	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1195464007331	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1195464007332	HNH endonuclease; Region: HNH_5; pfam14279
1195464007333	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1195464007334	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1195464007335	active site
1195464007336	dimer interface [polypeptide binding]; other site
1195464007337	non-prolyl cis peptide bond; other site
1195464007338	insertion regions; other site
1195464007339	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1195464007340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1195464007341	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1195464007342	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464007343	substrate binding pocket [chemical binding]; other site
1195464007344	membrane-bound complex binding site; other site
1195464007345	hinge residues; other site
1195464007346	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1195464007347	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1195464007348	Walker A/P-loop; other site
1195464007349	ATP binding site [chemical binding]; other site
1195464007350	Q-loop/lid; other site
1195464007351	ABC transporter signature motif; other site
1195464007352	Walker B; other site
1195464007353	D-loop; other site
1195464007354	H-loop/switch region; other site
1195464007355	Protein of unknown function (DUF402); Region: DUF402; pfam04167
1195464007356	Tetratrico peptide repeat; Region: TPR_5; pfam12688
1195464007357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464007358	binding surface
1195464007359	TPR motif; other site
1195464007360	hypothetical protein; Provisional; Region: PRK09620
1195464007361	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1195464007362	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1195464007363	Predicted membrane protein [Function unknown]; Region: COG2311
1195464007364	Protein of unknown function (DUF418); Region: DUF418; cl12135
1195464007365	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1195464007366	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1195464007367	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464007368	Coenzyme A binding pocket [chemical binding]; other site
1195464007369	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1195464007370	metal-dependent hydrolase; Provisional; Region: PRK13291
1195464007371	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1195464007372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007373	Coenzyme A binding pocket [chemical binding]; other site
1195464007374	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464007375	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464007376	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1195464007377	active site
1195464007378	NTP binding site [chemical binding]; other site
1195464007379	metal binding triad [ion binding]; metal-binding site
1195464007380	antibiotic binding site [chemical binding]; other site
1195464007381	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1195464007382	active site
1195464007383	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1195464007384	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1195464007385	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464007386	catalytic residue [active]
1195464007387	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464007388	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1195464007389	active site
1195464007390	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464007391	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1195464007392	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1195464007393	conserved cys residue [active]
1195464007394	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464007395	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1195464007396	NodB motif; other site
1195464007397	active site
1195464007398	catalytic site [active]
1195464007399	Zn binding site [ion binding]; other site
1195464007400	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1195464007401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464007402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464007403	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1195464007404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007405	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464007406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007407	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1195464007408	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1195464007409	Sulfatase; Region: Sulfatase; pfam00884
1195464007410	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1195464007411	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464007412	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464007413	ABC transporter; Region: ABC_tran_2; pfam12848
1195464007414	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464007415	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1195464007416	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1195464007417	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464007418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464007419	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1195464007420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007421	Coenzyme A binding pocket [chemical binding]; other site
1195464007422	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1195464007423	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1195464007424	hinge; other site
1195464007425	active site
1195464007426	prephenate dehydrogenase; Validated; Region: PRK06545
1195464007427	prephenate dehydrogenase; Validated; Region: PRK08507
1195464007428	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1195464007429	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1195464007430	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464007431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464007432	homodimer interface [polypeptide binding]; other site
1195464007433	catalytic residue [active]
1195464007434	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1195464007435	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1195464007436	Tetramer interface [polypeptide binding]; other site
1195464007437	active site
1195464007438	FMN-binding site [chemical binding]; other site
1195464007439	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1195464007440	Chorismate mutase type II; Region: CM_2; cl00693
1195464007441	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1195464007442	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
1195464007443	Domain of unknown function (DUF4020); Region: DUF4020; pfam13212
1195464007444	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1195464007445	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464007446	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1195464007447	catalytic triad [active]
1195464007448	conserved cis-peptide bond; other site
1195464007449	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464007450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007451	Coenzyme A binding pocket [chemical binding]; other site
1195464007452	hypothetical protein; Provisional; Region: PRK06762
1195464007453	Shikimate kinase; Region: SKI; pfam01202
1195464007454	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1195464007455	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464007456	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464007457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464007458	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1195464007459	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464007460	putative metal binding site [ion binding]; other site
1195464007461	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464007462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007463	Coenzyme A binding pocket [chemical binding]; other site
1195464007464	Predicted flavoprotein [General function prediction only]; Region: COG0431
1195464007465	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464007466	DinB superfamily; Region: DinB_2; pfam12867
1195464007467	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1195464007468	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
1195464007469	malate:quinone oxidoreductase; Validated; Region: PRK05257
1195464007470	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1195464007471	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
1195464007472	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1195464007473	ligand binding site [chemical binding]; other site
1195464007474	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1195464007475	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464007476	TM-ABC transporter signature motif; other site
1195464007477	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464007478	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1195464007479	TM-ABC transporter signature motif; other site
1195464007480	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1195464007481	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1195464007482	Walker A/P-loop; other site
1195464007483	ATP binding site [chemical binding]; other site
1195464007484	Q-loop/lid; other site
1195464007485	ABC transporter signature motif; other site
1195464007486	Walker B; other site
1195464007487	D-loop; other site
1195464007488	H-loop/switch region; other site
1195464007489	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1195464007490	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1195464007491	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1195464007492	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
1195464007493	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
1195464007494	putative N- and C-terminal domain interface [polypeptide binding]; other site
1195464007495	putative active site [active]
1195464007496	putative MgATP binding site [chemical binding]; other site
1195464007497	catalytic site [active]
1195464007498	metal binding site [ion binding]; metal-binding site
1195464007499	putative carbohydrate binding site [chemical binding]; other site
1195464007500	Cupin domain; Region: Cupin_2; pfam07883
1195464007501	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
1195464007502	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1195464007503	putative active site; other site
1195464007504	catalytic residue [active]
1195464007505	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464007506	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464007507	Flavivirus non-structural Protein NS1; Region: Flavi_NS1; pfam00948
1195464007508	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464007509	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1195464007510	active site
1195464007511	metal binding site [ion binding]; metal-binding site
1195464007512	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1195464007513	active site
1195464007514	NTP binding site [chemical binding]; other site
1195464007515	metal binding triad [ion binding]; metal-binding site
1195464007516	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1195464007517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007518	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464007519	putative substrate translocation pore; other site
1195464007520	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464007521	dimerization interface [polypeptide binding]; other site
1195464007522	putative DNA binding site [nucleotide binding]; other site
1195464007523	putative Zn2+ binding site [ion binding]; other site
1195464007524	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1195464007525	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1195464007526	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1195464007527	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1195464007528	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
1195464007529	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
1195464007530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464007531	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464007532	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1195464007533	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1195464007534	putative catalytic cysteine [active]
1195464007535	gamma-glutamyl kinase; Provisional; Region: PRK05429
1195464007536	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1195464007537	nucleotide binding site [chemical binding]; other site
1195464007538	homotetrameric interface [polypeptide binding]; other site
1195464007539	putative phosphate binding site [ion binding]; other site
1195464007540	putative allosteric binding site; other site
1195464007541	PUA domain; Region: PUA; pfam01472
1195464007542	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1195464007543	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1195464007544	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
1195464007545	putative metal binding site [ion binding]; other site
1195464007546	putative dimer interface [polypeptide binding]; other site
1195464007547	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1195464007548	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1195464007549	Bacterial transcriptional regulator; Region: IclR; pfam01614
1195464007550	S-methylmethionine transporter; Provisional; Region: PRK11387
1195464007551	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1195464007552	active site
1195464007553	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1195464007554	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1195464007555	putative di-iron ligands [ion binding]; other site
1195464007556	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1195464007557	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1195464007558	dimer interface [polypeptide binding]; other site
1195464007559	active site
1195464007560	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1195464007561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464007562	salt bridge; other site
1195464007563	non-specific DNA binding site [nucleotide binding]; other site
1195464007564	sequence-specific DNA binding site [nucleotide binding]; other site
1195464007565	Protein of unknown function (DUF962); Region: DUF962; pfam06127
1195464007566	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1195464007567	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464007568	active site
1195464007569	motif I; other site
1195464007570	motif II; other site
1195464007571	uridine kinase; Provisional; Region: PRK07667
1195464007572	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464007573	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464007574	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464007575	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464007576	active site
1195464007577	metal binding site [ion binding]; metal-binding site
1195464007578	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1195464007579	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464007580	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1195464007581	MoxR-like ATPases [General function prediction only]; Region: COG0714
1195464007582	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464007583	Walker A motif; other site
1195464007584	ATP binding site [chemical binding]; other site
1195464007585	Walker B motif; other site
1195464007586	arginine finger; other site
1195464007587	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1195464007588	Protein of unknown function DUF58; Region: DUF58; pfam01882
1195464007589	Domain of unknown function (DUF4018); Region: DUF4018; pfam13210
1195464007590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007591	metabolite-proton symporter; Region: 2A0106; TIGR00883
1195464007592	putative substrate translocation pore; other site
1195464007593	acetylornithine aminotransferase; Provisional; Region: PRK02627
1195464007594	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464007595	inhibitor-cofactor binding pocket; inhibition site
1195464007596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464007597	catalytic residue [active]
1195464007598	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1195464007599	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1195464007600	heme binding pocket [chemical binding]; other site
1195464007601	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1195464007602	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1195464007603	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1195464007604	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1195464007605	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1195464007606	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1195464007607	active site
1195464007608	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1195464007609	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464007610	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464007611	Protein of unknown function (DUF3902); Region: DUF3902; pfam13042
1195464007612	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1195464007613	Protein of unknown function DUF58; Region: DUF58; pfam01882
1195464007614	MoxR-like ATPases [General function prediction only]; Region: COG0714
1195464007615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464007616	Walker A motif; other site
1195464007617	ATP binding site [chemical binding]; other site
1195464007618	Walker B motif; other site
1195464007619	arginine finger; other site
1195464007620	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1195464007621	LXG domain of WXG superfamily; Region: LXG; pfam04740
1195464007622	Protein of unknown function (DUF3958); Region: DUF3958; pfam13125
1195464007623	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1195464007624	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1195464007625	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1195464007626	dimer interface [polypeptide binding]; other site
1195464007627	FMN binding site [chemical binding]; other site
1195464007628	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464007629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464007630	putative DNA binding site [nucleotide binding]; other site
1195464007631	putative Zn2+ binding site [ion binding]; other site
1195464007632	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1195464007633	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1195464007634	G1 box; other site
1195464007635	putative GEF interaction site [polypeptide binding]; other site
1195464007636	GTP/Mg2+ binding site [chemical binding]; other site
1195464007637	Switch I region; other site
1195464007638	G2 box; other site
1195464007639	G3 box; other site
1195464007640	Switch II region; other site
1195464007641	G4 box; other site
1195464007642	G5 box; other site
1195464007643	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
1195464007644	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
1195464007645	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1195464007646	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1195464007647	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
1195464007648	nudix motif; other site
1195464007649	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
1195464007650	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
1195464007651	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1195464007652	putative NAD(P) binding site [chemical binding]; other site
1195464007653	active site
1195464007654	CAAX protease self-immunity; Region: Abi; pfam02517
1195464007655	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464007656	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464007657	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1195464007658	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464007659	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1195464007660	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1195464007661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007662	Coenzyme A binding pocket [chemical binding]; other site
1195464007663	Domain of unknown function (DUF3980); Region: DUF3980; pfam13140
1195464007664	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1195464007665	nudix motif; other site
1195464007666	EamA-like transporter family; Region: EamA; pfam00892
1195464007667	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464007668	EamA-like transporter family; Region: EamA; pfam00892
1195464007669	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464007670	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464007671	DNA-binding site [nucleotide binding]; DNA binding site
1195464007672	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464007673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464007674	homodimer interface [polypeptide binding]; other site
1195464007675	catalytic residue [active]
1195464007676	Cupin domain; Region: Cupin_2; cl17218
1195464007677	hypothetical protein; Validated; Region: PRK00124
1195464007678	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1195464007679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464007680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464007681	phosphorylation site [posttranslational modification]
1195464007682	dimer interface [polypeptide binding]; other site
1195464007683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464007684	ATP binding site [chemical binding]; other site
1195464007685	Mg2+ binding site [ion binding]; other site
1195464007686	G-X-G motif; other site
1195464007687	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464007688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464007689	active site
1195464007690	phosphorylation site [posttranslational modification]
1195464007691	intermolecular recognition site; other site
1195464007692	dimerization interface [polypeptide binding]; other site
1195464007693	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1195464007694	DNA binding site [nucleotide binding]
1195464007695	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464007696	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1195464007697	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1195464007698	uridine kinase; Validated; Region: PRK06696
1195464007699	AAA domain; Region: AAA_18; pfam13238
1195464007700	active site
1195464007701	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464007702	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1195464007703	active site
1195464007704	metal binding site [ion binding]; metal-binding site
1195464007705	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464007706	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1195464007707	active site
1195464007708	ATP binding site [chemical binding]; other site
1195464007709	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1195464007710	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464007711	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464007712	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464007713	Coenzyme A binding pocket [chemical binding]; other site
1195464007714	lysine transporter; Provisional; Region: PRK10836
1195464007715	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1195464007716	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1195464007717	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
1195464007718	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1195464007719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464007720	S-adenosylmethionine binding site [chemical binding]; other site
1195464007721	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1195464007722	putative active site [active]
1195464007723	nucleotide binding site [chemical binding]; other site
1195464007724	nudix motif; other site
1195464007725	putative metal binding site [ion binding]; other site
1195464007726	Cephalosporin hydroxylase; Region: CmcI; pfam04989
1195464007727	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1195464007728	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464007729	Catalytic site [active]
1195464007730	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464007731	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464007732	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464007733	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464007734	NAD-dependent deacetylase; Provisional; Region: PRK00481
1195464007735	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
1195464007736	NAD+ binding site [chemical binding]; other site
1195464007737	substrate binding site [chemical binding]; other site
1195464007738	Zn binding site [ion binding]; other site
1195464007739	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1195464007740	putative substrate binding pocket [chemical binding]; other site
1195464007741	AC domain interface; other site
1195464007742	catalytic triad [active]
1195464007743	AB domain interface; other site
1195464007744	interchain disulfide; other site
1195464007745	Predicted membrane protein [Function unknown]; Region: COG3817
1195464007746	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1195464007747	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1195464007748	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1195464007749	putative active site [active]
1195464007750	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1195464007751	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1195464007752	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1195464007753	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1195464007754	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1195464007755	Bacterial transcriptional regulator; Region: IclR; pfam01614
1195464007756	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1195464007757	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1195464007758	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464007759	Catalytic site [active]
1195464007760	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1195464007761	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464007762	dimerization interface [polypeptide binding]; other site
1195464007763	putative DNA binding site [nucleotide binding]; other site
1195464007764	putative Zn2+ binding site [ion binding]; other site
1195464007765	DinB superfamily; Region: DinB_2; pfam12867
1195464007766	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1195464007767	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1195464007768	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1195464007769	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1195464007770	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1195464007771	putative active site [active]
1195464007772	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464007773	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464007774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1195464007775	Nucleoside recognition; Region: Gate; pfam07670
1195464007776	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1195464007777	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1195464007778	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464007779	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1195464007780	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464007781	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1195464007782	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464007783	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
1195464007784	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464007785	putative active site [active]
1195464007786	putative substrate binding site [chemical binding]; other site
1195464007787	ATP binding site [chemical binding]; other site
1195464007788	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464007789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007790	Coenzyme A binding pocket [chemical binding]; other site
1195464007791	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
1195464007792	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1195464007793	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1195464007794	dinuclear metal binding motif [ion binding]; other site
1195464007795	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1195464007796	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1195464007797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464007798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464007799	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1195464007800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1195464007801	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1195464007802	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1195464007803	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1195464007804	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1195464007805	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464007806	heme-binding site [chemical binding]; other site
1195464007807	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007808	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1195464007809	Leucine rich repeat; Region: LRR_8; pfam13855
1195464007810	Leucine-rich repeats; other site
1195464007811	Substrate binding site [chemical binding]; other site
1195464007812	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007813	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007814	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007815	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007816	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007817	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464007818	LRR adjacent; Region: LRR_adjacent; pfam08191
1195464007819	YolD-like protein; Region: YolD; pfam08863
1195464007820	DNA polymerase IV; Reviewed; Region: PRK03103
1195464007821	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1195464007822	active site
1195464007823	DNA binding site [nucleotide binding]
1195464007824	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1195464007825	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1195464007826	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1195464007827	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1195464007828	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1195464007829	putative active site [active]
1195464007830	putative metal binding site [ion binding]; other site
1195464007831	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1195464007832	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464007833	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1195464007834	TAP-like protein; Region: Abhydrolase_4; pfam08386
1195464007835	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464007836	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1195464007837	catalytic triad [active]
1195464007838	dimer interface [polypeptide binding]; other site
1195464007839	conserved cis-peptide bond; other site
1195464007840	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464007841	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1195464007842	catalytic triad [active]
1195464007843	dimer interface [polypeptide binding]; other site
1195464007844	conserved cis-peptide bond; other site
1195464007845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1195464007846	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1195464007847	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1195464007848	active site
1195464007849	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1195464007850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464007851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464007852	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464007853	dimerization interface [polypeptide binding]; other site
1195464007854	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
1195464007855	Cl binding site [ion binding]; other site
1195464007856	oligomer interface [polypeptide binding]; other site
1195464007857	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1195464007858	plasmid segregation protein ParM; Provisional; Region: PRK13917
1195464007859	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1195464007860	Mg binding site [ion binding]; other site
1195464007861	nucleotide binding site [chemical binding]; other site
1195464007862	putative protofilament interface [polypeptide binding]; other site
1195464007863	Heat induced stress protein YflT; Region: YflT; pfam11181
1195464007864	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464007865	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1195464007866	TspO/MBR family; Region: TspO_MBR; pfam03073
1195464007867	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1195464007868	DNA photolyase; Region: DNA_photolyase; pfam00875
1195464007869	Carbonic anhydrase; Region: Pro_CA; pfam00484
1195464007870	zinc binding site [ion binding]; other site
1195464007871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1195464007872	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1195464007873	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
1195464007874	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1195464007875	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
1195464007876	Spore germination protein; Region: Spore_permease; cl17796
1195464007877	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464007878	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464007879	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464007880	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464007881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464007882	Coenzyme A binding pocket [chemical binding]; other site
1195464007883	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1195464007884	UbiA prenyltransferase family; Region: UbiA; pfam01040
1195464007885	DJ-1 family protein; Region: not_thiJ; TIGR01383
1195464007886	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1195464007887	conserved cys residue [active]
1195464007888	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464007889	active site
1195464007890	ATP binding site [chemical binding]; other site
1195464007891	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1195464007892	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1195464007893	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1195464007894	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1195464007895	arsenical-resistance protein; Region: acr3; TIGR00832
1195464007896	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464007897	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1195464007898	putative metal binding site [ion binding]; other site
1195464007899	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464007900	dimerization interface [polypeptide binding]; other site
1195464007901	putative DNA binding site [nucleotide binding]; other site
1195464007902	putative Zn2+ binding site [ion binding]; other site
1195464007903	DinB superfamily; Region: DinB_2; pfam12867
1195464007904	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1195464007905	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1195464007906	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1195464007907	putative NAD(P) binding site [chemical binding]; other site
1195464007908	active site
1195464007909	putative substrate binding site [chemical binding]; other site
1195464007910	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464007911	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464007912	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464007913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464007914	DNA-binding site [nucleotide binding]; DNA binding site
1195464007915	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
1195464007916	FadR C-terminal domain; Region: FadR_C; pfam07840
1195464007917	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1195464007918	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464007919	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464007920	Spore germination protein; Region: Spore_permease; cl17796
1195464007921	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464007922	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464007923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007924	putative substrate translocation pore; other site
1195464007925	short chain dehydrogenase; Provisional; Region: PRK12746
1195464007926	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1195464007927	NADP binding site [chemical binding]; other site
1195464007928	homodimer interface [polypeptide binding]; other site
1195464007929	active site
1195464007930	substrate binding site [chemical binding]; other site
1195464007931	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1195464007932	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464007933	putative DNA binding site [nucleotide binding]; other site
1195464007934	putative Zn2+ binding site [ion binding]; other site
1195464007935	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464007936	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1195464007937	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464007938	metal binding site [ion binding]; metal-binding site
1195464007939	AAA domain; Region: AAA_11; pfam13086
1195464007940	Part of AAA domain; Region: AAA_19; pfam13245
1195464007941	Erp protein C-terminus; Region: Erp_C; pfam06780
1195464007942	AAA domain; Region: AAA_30; pfam13604
1195464007943	AAA domain; Region: AAA_12; pfam13087
1195464007944	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1195464007945	putative active site [active]
1195464007946	catalytic site [active]
1195464007947	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464007948	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1195464007949	active site
1195464007950	metal binding site [ion binding]; metal-binding site
1195464007951	putative monooxygenase; Provisional; Region: PRK11118
1195464007952	DoxX-like family; Region: DoxX_2; pfam13564
1195464007953	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1195464007954	MarR family; Region: MarR_2; pfam12802
1195464007955	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1195464007956	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1195464007957	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1195464007958	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1195464007959	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1195464007960	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1195464007961	Cytochrome P450; Region: p450; pfam00067
1195464007962	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1195464007963	Flavodoxin; Region: Flavodoxin_1; pfam00258
1195464007964	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1195464007965	FAD binding pocket [chemical binding]; other site
1195464007966	FAD binding motif [chemical binding]; other site
1195464007967	catalytic residues [active]
1195464007968	NAD binding pocket [chemical binding]; other site
1195464007969	phosphate binding motif [ion binding]; other site
1195464007970	beta-alpha-beta structure motif; other site
1195464007971	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1195464007972	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1195464007973	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1195464007974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007975	putative substrate translocation pore; other site
1195464007976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464007977	D-cysteine desulfhydrase; Validated; Region: PRK03910
1195464007978	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1195464007979	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464007980	catalytic residue [active]
1195464007981	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1195464007982	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464007983	active site
1195464007984	metal binding site [ion binding]; metal-binding site
1195464007985	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
1195464007986	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464007987	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464007988	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
1195464007989	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1195464007990	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1195464007991	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464007992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464007993	NAD(P) binding site [chemical binding]; other site
1195464007994	active site
1195464007995	hypothetical protein; Provisional; Region: PRK06849
1195464007996	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1195464007997	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
1195464007998	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1195464007999	dimer interface [polypeptide binding]; other site
1195464008000	active site
1195464008001	CoA binding pocket [chemical binding]; other site
1195464008002	Protein of unknown function (DUF975); Region: DUF975; cl10504
1195464008003	Protein of unknown function (DUF975); Region: DUF975; cl10504
1195464008004	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1195464008005	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1195464008006	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1195464008007	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464008008	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464008009	Walker A/P-loop; other site
1195464008010	ATP binding site [chemical binding]; other site
1195464008011	Q-loop/lid; other site
1195464008012	ABC transporter signature motif; other site
1195464008013	Walker B; other site
1195464008014	D-loop; other site
1195464008015	H-loop/switch region; other site
1195464008016	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1195464008017	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464008018	FtsX-like permease family; Region: FtsX; pfam02687
1195464008019	DinB superfamily; Region: DinB_2; pfam12867
1195464008020	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1195464008021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464008022	dimerization interface [polypeptide binding]; other site
1195464008023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464008024	dimer interface [polypeptide binding]; other site
1195464008025	phosphorylation site [posttranslational modification]
1195464008026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464008027	ATP binding site [chemical binding]; other site
1195464008028	Mg2+ binding site [ion binding]; other site
1195464008029	G-X-G motif; other site
1195464008030	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464008031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464008032	active site
1195464008033	phosphorylation site [posttranslational modification]
1195464008034	intermolecular recognition site; other site
1195464008035	dimerization interface [polypeptide binding]; other site
1195464008036	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464008037	DNA binding site [nucleotide binding]
1195464008038	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464008039	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464008040	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464008041	F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763
1195464008042	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1195464008043	putative dimer interface [polypeptide binding]; other site
1195464008044	catalytic triad [active]
1195464008045	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
1195464008046	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1195464008047	dimer interaction site [polypeptide binding]; other site
1195464008048	substrate-binding tunnel; other site
1195464008049	active site
1195464008050	catalytic site [active]
1195464008051	substrate binding site [chemical binding]; other site
1195464008052	Uncharacterized conserved protein [Function unknown]; Region: COG4198
1195464008053	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
1195464008054	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1195464008055	putative ligand binding site [chemical binding]; other site
1195464008056	putative NAD binding site [chemical binding]; other site
1195464008057	putative catalytic site [active]
1195464008058	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1195464008059	L-serine binding site [chemical binding]; other site
1195464008060	ACT domain interface; other site
1195464008061	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1195464008062	homodimer interface [polypeptide binding]; other site
1195464008063	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464008064	substrate-cofactor binding pocket; other site
1195464008065	catalytic residue [active]
1195464008066	Domain of unknown function (DUF378); Region: DUF378; cl00943
1195464008067	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1195464008068	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1195464008069	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1195464008070	active site
1195464008071	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1195464008072	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1195464008073	active site
1195464008074	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1195464008075	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1195464008076	active site
1195464008077	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
1195464008078	Protein of unknown function, DUF600; Region: DUF600; cl04640
1195464008079	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1195464008080	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1195464008081	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
1195464008082	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1195464008083	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1195464008084	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1195464008085	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1195464008086	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1195464008087	putative active site [active]
1195464008088	putative metal binding site [ion binding]; other site
1195464008089	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1195464008090	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1195464008091	active site
1195464008092	aminotransferase; Validated; Region: PRK07678
1195464008093	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464008094	inhibitor-cofactor binding pocket; inhibition site
1195464008095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464008096	catalytic residue [active]
1195464008097	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1195464008098	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1195464008099	tetrameric interface [polypeptide binding]; other site
1195464008100	NAD binding site [chemical binding]; other site
1195464008101	catalytic residues [active]
1195464008102	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
1195464008103	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1195464008104	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1195464008105	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1195464008106	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1195464008107	tetramerization interface [polypeptide binding]; other site
1195464008108	NAD(P) binding site [chemical binding]; other site
1195464008109	catalytic residues [active]
1195464008110	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1195464008111	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1195464008112	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777
1195464008113	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464008114	DNA binding residues [nucleotide binding]
1195464008115	putative dimer interface [polypeptide binding]; other site
1195464008116	NETI protein; Region: NETI; pfam14044
1195464008117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008118	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464008119	putative substrate translocation pore; other site
1195464008120	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464008121	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1195464008122	TAP-like protein; Region: Abhydrolase_4; pfam08386
1195464008123	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464008124	MarR family; Region: MarR_2; pfam12802
1195464008125	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464008126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008127	putative substrate translocation pore; other site
1195464008128	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464008129	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464008130	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464008131	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464008132	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464008133	FtsX-like permease family; Region: FtsX; pfam02687
1195464008134	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464008135	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464008136	Walker A/P-loop; other site
1195464008137	ATP binding site [chemical binding]; other site
1195464008138	Q-loop/lid; other site
1195464008139	ABC transporter signature motif; other site
1195464008140	Walker B; other site
1195464008141	D-loop; other site
1195464008142	H-loop/switch region; other site
1195464008143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464008144	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464008145	dimerization interface [polypeptide binding]; other site
1195464008146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464008147	dimer interface [polypeptide binding]; other site
1195464008148	phosphorylation site [posttranslational modification]
1195464008149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464008150	ATP binding site [chemical binding]; other site
1195464008151	Mg2+ binding site [ion binding]; other site
1195464008152	G-X-G motif; other site
1195464008153	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464008154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464008155	active site
1195464008156	phosphorylation site [posttranslational modification]
1195464008157	intermolecular recognition site; other site
1195464008158	dimerization interface [polypeptide binding]; other site
1195464008159	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464008160	DNA binding site [nucleotide binding]
1195464008161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1195464008162	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
1195464008163	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1195464008164	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1195464008165	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464008166	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1195464008167	SWIM zinc finger; Region: SWIM; pfam04434
1195464008168	YwiC-like protein; Region: YwiC; pfam14256
1195464008169	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1195464008170	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464008171	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1195464008172	Walker A/P-loop; other site
1195464008173	ATP binding site [chemical binding]; other site
1195464008174	Q-loop/lid; other site
1195464008175	ABC transporter signature motif; other site
1195464008176	Walker B; other site
1195464008177	D-loop; other site
1195464008178	H-loop/switch region; other site
1195464008179	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464008180	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
1195464008181	Walker A/P-loop; other site
1195464008182	ATP binding site [chemical binding]; other site
1195464008183	Q-loop/lid; other site
1195464008184	ABC transporter signature motif; other site
1195464008185	Walker B; other site
1195464008186	D-loop; other site
1195464008187	H-loop/switch region; other site
1195464008188	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1195464008189	Calreticulin family; Region: Calreticulin; pfam00262
1195464008190	Calreticulin family; Region: Calreticulin; pfam00262
1195464008191	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1195464008192	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1195464008193	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1195464008194	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1195464008195	Predicted membrane protein [Function unknown]; Region: COG1288
1195464008196	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1195464008197	Endonuclease I; Region: Endonuclease_1; pfam04231
1195464008198	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1195464008199	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1195464008200	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1195464008201	putative deacylase active site [active]
1195464008202	histidyl-tRNA synthetase; Provisional; Region: PRK12420
1195464008203	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1195464008204	dimer interface [polypeptide binding]; other site
1195464008205	motif 1; other site
1195464008206	active site
1195464008207	motif 2; other site
1195464008208	motif 3; other site
1195464008209	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1195464008210	anticodon binding site; other site
1195464008211	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464008212	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1195464008213	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1195464008214	dimer interface [polypeptide binding]; other site
1195464008215	FMN binding site [chemical binding]; other site
1195464008216	pyruvate kinase; Validated; Region: PRK06739
1195464008217	active site
1195464008218	domain interfaces; other site
1195464008219	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
1195464008220	classical (c) SDRs; Region: SDR_c; cd05233
1195464008221	NAD(P) binding site [chemical binding]; other site
1195464008222	active site
1195464008223	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1195464008224	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464008225	Walker A/P-loop; other site
1195464008226	ATP binding site [chemical binding]; other site
1195464008227	Q-loop/lid; other site
1195464008228	ABC transporter signature motif; other site
1195464008229	Walker B; other site
1195464008230	D-loop; other site
1195464008231	H-loop/switch region; other site
1195464008232	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
1195464008233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464008234	non-specific DNA binding site [nucleotide binding]; other site
1195464008235	salt bridge; other site
1195464008236	sequence-specific DNA binding site [nucleotide binding]; other site
1195464008237	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1195464008238	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464008239	motif II; other site
1195464008240	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464008241	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464008242	active site
1195464008243	substrate binding site [chemical binding]; other site
1195464008244	ATP binding site [chemical binding]; other site
1195464008245	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1195464008246	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1195464008247	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1195464008248	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1195464008249	nudix motif; other site
1195464008250	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1195464008251	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1195464008252	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464008253	putative metal binding site [ion binding]; other site
1195464008254	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1195464008255	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1195464008256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008257	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464008258	putative substrate translocation pore; other site
1195464008259	maltose O-acetyltransferase; Provisional; Region: PRK10092
1195464008260	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1195464008261	active site
1195464008262	substrate binding site [chemical binding]; other site
1195464008263	trimer interface [polypeptide binding]; other site
1195464008264	CoA binding site [chemical binding]; other site
1195464008265	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1195464008266	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1195464008267	active site
1195464008268	HIGH motif; other site
1195464008269	dimer interface [polypeptide binding]; other site
1195464008270	KMSKS motif; other site
1195464008271	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464
1195464008272	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1195464008273	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1195464008274	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1195464008275	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1195464008276	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1195464008277	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464008278	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464008279	Coenzyme A binding pocket [chemical binding]; other site
1195464008280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464008281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1195464008282	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1195464008283	CGNR zinc finger; Region: zf-CGNR; pfam11706
1195464008284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464008286	putative substrate translocation pore; other site
1195464008287	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464008288	TPR motif; other site
1195464008289	TPR repeat; Region: TPR_11; pfam13414
1195464008290	binding surface
1195464008291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464008292	binding surface
1195464008293	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1195464008294	TPR motif; other site
1195464008295	hypothetical protein; Provisional; Region: PRK04164
1195464008296	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464008297	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1195464008298	Domain of unknown function DUF21; Region: DUF21; pfam01595
1195464008299	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1195464008300	Transporter associated domain; Region: CorC_HlyC; smart01091
1195464008301	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
1195464008302	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464008303	DNA binding residues [nucleotide binding]
1195464008304	putative dimer interface [polypeptide binding]; other site
1195464008305	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1195464008306	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1195464008307	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1195464008308	substrate binding site; other site
1195464008309	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1195464008310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464008311	NAD(P) binding site [chemical binding]; other site
1195464008312	active site
1195464008313	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464008314	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1195464008315	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1195464008316	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1195464008317	EamA-like transporter family; Region: EamA; pfam00892
1195464008318	EamA-like transporter family; Region: EamA; cl17759
1195464008319	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1195464008320	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1195464008321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1195464008322	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1195464008323	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1195464008324	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1195464008325	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1195464008326	N- and C-terminal domain interface [polypeptide binding]; other site
1195464008327	active site
1195464008328	catalytic site [active]
1195464008329	metal binding site [ion binding]; metal-binding site
1195464008330	carbohydrate binding site [chemical binding]; other site
1195464008331	ATP binding site [chemical binding]; other site
1195464008332	GntP family permease; Region: GntP_permease; pfam02447
1195464008333	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1195464008334	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1195464008335	active site
1195464008336	intersubunit interactions; other site
1195464008337	catalytic residue [active]
1195464008338	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1195464008339	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1195464008340	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1195464008341	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1195464008342	TPP-binding site [chemical binding]; other site
1195464008343	dimer interface [polypeptide binding]; other site
1195464008344	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1195464008345	PYR/PP interface [polypeptide binding]; other site
1195464008346	dimer interface [polypeptide binding]; other site
1195464008347	TPP binding site [chemical binding]; other site
1195464008348	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464008349	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1195464008350	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1195464008351	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1195464008352	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1195464008353	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464008354	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1195464008355	putative NAD(P) binding site [chemical binding]; other site
1195464008356	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
1195464008357	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1195464008358	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
1195464008359	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464008360	putative NAD(P) binding site [chemical binding]; other site
1195464008361	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1195464008362	classical (c) SDRs; Region: SDR_c; cd05233
1195464008363	NAD(P) binding site [chemical binding]; other site
1195464008364	active site
1195464008365	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464008366	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464008367	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1195464008368	active site
1195464008369	Zn binding site [ion binding]; other site
1195464008370	Viral enhancin protein; Region: Enhancin; pfam03272
1195464008371	Peptidase M60-like family; Region: M60-like; pfam13402
1195464008372	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1195464008373	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464008374	dimerization interface [polypeptide binding]; other site
1195464008375	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464008376	dimer interface [polypeptide binding]; other site
1195464008377	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1195464008378	putative CheW interface [polypeptide binding]; other site
1195464008379	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1195464008380	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464008381	motif II; other site
1195464008382	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1195464008383	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1195464008384	catalytic motif [active]
1195464008385	Zn binding site [ion binding]; other site
1195464008386	RibD C-terminal domain; Region: RibD_C; cl17279
1195464008387	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1195464008388	dimerization interface [polypeptide binding]; other site
1195464008389	active site
1195464008390	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464008391	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1195464008392	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1195464008393	dimer interface [polypeptide binding]; other site
1195464008394	FMN binding site [chemical binding]; other site
1195464008395	BNR repeat-like domain; Region: BNR_2; pfam13088
1195464008396	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464008397	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464008398	active site
1195464008399	catalytic tetrad [active]
1195464008400	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464008401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008402	putative substrate translocation pore; other site
1195464008403	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1195464008404	hexamer interface [polypeptide binding]; other site
1195464008405	active site 2 [active]
1195464008406	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1195464008407	hexamer interface [polypeptide binding]; other site
1195464008408	active site 2 [active]
1195464008409	hypothetical protein; Provisional; Region: PRK02487
1195464008410	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1195464008411	MarR family; Region: MarR_2; cl17246
1195464008412	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1195464008413	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1195464008414	PhnA protein; Region: PhnA; pfam03831
1195464008415	putative transporter; Provisional; Region: PRK11660
1195464008416	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1195464008417	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1195464008418	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1195464008419	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008420	dimerization interface [polypeptide binding]; other site
1195464008421	putative DNA binding site [nucleotide binding]; other site
1195464008422	putative Zn2+ binding site [ion binding]; other site
1195464008423	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1195464008424	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1195464008425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464008426	salt bridge; other site
1195464008427	non-specific DNA binding site [nucleotide binding]; other site
1195464008428	sequence-specific DNA binding site [nucleotide binding]; other site
1195464008429	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1195464008430	IDEAL domain; Region: IDEAL; pfam08858
1195464008431	Predicted transcriptional regulator [Transcription]; Region: COG1959
1195464008432	Transcriptional regulator; Region: Rrf2; pfam02082
1195464008433	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1195464008434	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1195464008435	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1195464008436	ArsC family; Region: ArsC; pfam03960
1195464008437	putative catalytic residues [active]
1195464008438	thiol/disulfide switch; other site
1195464008439	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464008440	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008441	dimerization interface [polypeptide binding]; other site
1195464008442	putative DNA binding site [nucleotide binding]; other site
1195464008443	putative Zn2+ binding site [ion binding]; other site
1195464008444	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1195464008445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464008446	DNA-binding site [nucleotide binding]; DNA binding site
1195464008447	UTRA domain; Region: UTRA; pfam07702
1195464008448	putative oxidoreductase; Provisional; Region: PRK10206
1195464008449	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1195464008450	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1195464008451	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1195464008452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1195464008453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464008454	S-adenosylmethionine binding site [chemical binding]; other site
1195464008455	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464008456	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1195464008457	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1195464008458	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1195464008459	Probable transposase; Region: OrfB_IS605; pfam01385
1195464008460	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464008461	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008462	dimerization interface [polypeptide binding]; other site
1195464008463	putative DNA binding site [nucleotide binding]; other site
1195464008464	putative Zn2+ binding site [ion binding]; other site
1195464008465	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464008466	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464008467	active site
1195464008468	catalytic tetrad [active]
1195464008469	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1195464008470	putative hydrophobic ligand binding site [chemical binding]; other site
1195464008471	protein interface [polypeptide binding]; other site
1195464008472	gate; other site
1195464008473	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1195464008474	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
1195464008475	putative active site [active]
1195464008476	putative catalytic triad [active]
1195464008477	Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838
1195464008478	catalytic triad [active]
1195464008479	oxyanion hole [active]
1195464008480	active site
1195464008481	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464008482	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464008483	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464008484	substrate binding site [chemical binding]; other site
1195464008485	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1195464008486	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1195464008487	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1195464008488	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1195464008489	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464008490	Coenzyme A binding pocket [chemical binding]; other site
1195464008491	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464008492	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464008493	Putative amidotransferase; Region: DUF4066; pfam13278
1195464008494	conserved cys residue [active]
1195464008495	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1195464008496	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1195464008497	acyl-activating enzyme (AAE) consensus motif; other site
1195464008498	AMP binding site [chemical binding]; other site
1195464008499	active site
1195464008500	CoA binding site [chemical binding]; other site
1195464008501	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1195464008502	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464008503	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008504	dimerization interface [polypeptide binding]; other site
1195464008505	putative DNA binding site [nucleotide binding]; other site
1195464008506	putative Zn2+ binding site [ion binding]; other site
1195464008507	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008508	dimerization interface [polypeptide binding]; other site
1195464008509	putative DNA binding site [nucleotide binding]; other site
1195464008510	putative Zn2+ binding site [ion binding]; other site
1195464008511	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1195464008512	active site
1195464008513	Glyco_18 domain; Region: Glyco_18; smart00636
1195464008514	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1195464008515	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
1195464008516	NodB motif; other site
1195464008517	putative active site [active]
1195464008518	putative catalytic site [active]
1195464008519	putative Zn binding site [ion binding]; other site
1195464008520	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1195464008521	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1195464008522	DXD motif; other site
1195464008523	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
1195464008524	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
1195464008525	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464008526	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464008527	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
1195464008528	active site
1195464008529	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1195464008530	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1195464008531	HTH domain; Region: HTH_11; pfam08279
1195464008532	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1195464008533	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1195464008534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464008535	Walker A/P-loop; other site
1195464008536	ATP binding site [chemical binding]; other site
1195464008537	Q-loop/lid; other site
1195464008538	ABC transporter signature motif; other site
1195464008539	Walker B; other site
1195464008540	D-loop; other site
1195464008541	H-loop/switch region; other site
1195464008542	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1195464008543	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464008544	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464008545	hydroxylamine reductase; Provisional; Region: PRK12310
1195464008546	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1195464008547	ACS interaction site; other site
1195464008548	CODH interaction site; other site
1195464008549	metal cluster binding site [ion binding]; other site
1195464008550	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464008551	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1195464008552	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1195464008553	active site
1195464008554	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1195464008555	metal binding site [ion binding]; metal-binding site
1195464008556	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
1195464008557	hypothetical protein; Provisional; Region: PRK06771
1195464008558	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464008559	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464008560	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1195464008561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1195464008562	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1195464008563	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464008564	active site
1195464008565	metal binding site [ion binding]; metal-binding site
1195464008566	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1195464008567	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464008568	ligand binding site [chemical binding]; other site
1195464008569	flexible hinge region; other site
1195464008570	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1195464008571	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1195464008572	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1195464008573	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464008574	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1195464008575	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1195464008576	putative NAD(P) binding site [chemical binding]; other site
1195464008577	dimer interface [polypeptide binding]; other site
1195464008578	putative transport protein YifK; Provisional; Region: PRK10746
1195464008579	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1195464008580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464008581	Coenzyme A binding pocket [chemical binding]; other site
1195464008582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008583	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1195464008584	putative substrate translocation pore; other site
1195464008585	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1195464008586	DinB superfamily; Region: DinB_2; pfam12867
1195464008587	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1195464008588	Haemolysin XhlA; Region: XhlA; pfam10779
1195464008589	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1195464008590	classical (c) SDRs; Region: SDR_c; cd05233
1195464008591	NAD(P) binding site [chemical binding]; other site
1195464008592	active site
1195464008593	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
1195464008594	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
1195464008595	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1195464008596	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1195464008597	transmembrane helices; other site
1195464008598	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464008599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464008600	Coenzyme A binding pocket [chemical binding]; other site
1195464008601	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464008602	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464008603	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1195464008604	putative ligand binding residues [chemical binding]; other site
1195464008605	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464008606	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464008607	ABC-ATPase subunit  interface; other site
1195464008608	dimer interface [polypeptide binding]; other site
1195464008609	putative PBP binding regions; other site
1195464008610	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464008611	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464008612	ABC-ATPase subunit  interface; other site
1195464008613	dimer interface [polypeptide binding]; other site
1195464008614	putative PBP binding regions; other site
1195464008615	Protein of unknown function (DUF817); Region: DUF817; pfam05675
1195464008616	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
1195464008617	DinB superfamily; Region: DinB_2; pfam12867
1195464008618	DinB family; Region: DinB; cl17821
1195464008619	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
1195464008620	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
1195464008621	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464008622	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464008623	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464008624	dimerization interface [polypeptide binding]; other site
1195464008625	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464008626	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1195464008627	NADP binding site [chemical binding]; other site
1195464008628	dimer interface [polypeptide binding]; other site
1195464008629	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464008630	catalytic core [active]
1195464008631	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464008632	Coenzyme A binding pocket [chemical binding]; other site
1195464008633	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
1195464008634	MutS domain III; Region: MutS_III; pfam05192
1195464008635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464008636	Walker A/P-loop; other site
1195464008637	ATP binding site [chemical binding]; other site
1195464008638	Q-loop/lid; other site
1195464008639	ABC transporter signature motif; other site
1195464008640	Walker B; other site
1195464008641	D-loop; other site
1195464008642	H-loop/switch region; other site
1195464008643	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1195464008644	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1195464008645	active site
1195464008646	Na/Ca binding site [ion binding]; other site
1195464008647	catalytic site [active]
1195464008648	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1195464008649	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1195464008650	oligoendopeptidase F; Region: pepF; TIGR00181
1195464008651	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1195464008652	active site
1195464008653	Zn binding site [ion binding]; other site
1195464008654	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1195464008655	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1195464008656	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1195464008657	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1195464008658	active site
1195464008659	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1195464008660	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1195464008661	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464008662	DNA binding residues [nucleotide binding]
1195464008663	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1195464008664	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1195464008665	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1195464008666	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1195464008667	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1195464008668	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1195464008669	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464008670	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464008671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464008672	putative substrate translocation pore; other site
1195464008673	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464008674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464008675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464008676	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1195464008677	putative dimerization interface [polypeptide binding]; other site
1195464008678	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
1195464008679	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1195464008680	putative active site [active]
1195464008681	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1195464008682	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1195464008683	active site
1195464008684	catalytic site [active]
1195464008685	metal binding site [ion binding]; metal-binding site
1195464008686	FAD binding domain; Region: FAD_binding_3; pfam01494
1195464008687	hypothetical protein; Provisional; Region: PRK07236
1195464008688	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1195464008689	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008690	dimerization interface [polypeptide binding]; other site
1195464008691	putative DNA binding site [nucleotide binding]; other site
1195464008692	putative Zn2+ binding site [ion binding]; other site
1195464008693	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464008694	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1195464008695	putative NAD(P) binding site [chemical binding]; other site
1195464008696	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1195464008697	hypothetical protein; Validated; Region: PRK00029
1195464008698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464008699	TPR motif; other site
1195464008700	binding surface
1195464008701	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1195464008702	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1195464008703	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1195464008704	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464008705	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
1195464008706	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464008707	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464008708	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1195464008709	active site
1195464008710	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464008711	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464008712	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1195464008713	PAS domain S-box; Region: sensory_box; TIGR00229
1195464008714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464008715	putative active site [active]
1195464008716	heme pocket [chemical binding]; other site
1195464008717	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464008718	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464008719	metal binding site [ion binding]; metal-binding site
1195464008720	active site
1195464008721	I-site; other site
1195464008722	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464008723	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464008724	Walker A/P-loop; other site
1195464008725	ATP binding site [chemical binding]; other site
1195464008726	Q-loop/lid; other site
1195464008727	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1195464008728	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1195464008729	TQXA domain; Region: TQXA_dom; TIGR03934
1195464008730	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464008731	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464008732	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464008733	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464008734	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464008735	dimerization interface [polypeptide binding]; other site
1195464008736	putative DNA binding site [nucleotide binding]; other site
1195464008737	putative Zn2+ binding site [ion binding]; other site
1195464008738	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1195464008739	Helix-turn-helix domain; Region: HTH_28; pfam13518
1195464008740	Helix-turn-helix domain; Region: HTH_28; pfam13518
1195464008741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1195464008742	HTH-like domain; Region: HTH_21; pfam13276
1195464008743	Integrase core domain; Region: rve; pfam00665
1195464008744	Integrase core domain; Region: rve_2; pfam13333
1195464008745	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1195464008746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464008747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464008748	dimer interface [polypeptide binding]; other site
1195464008749	phosphorylation site [posttranslational modification]
1195464008750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464008751	ATP binding site [chemical binding]; other site
1195464008752	Mg2+ binding site [ion binding]; other site
1195464008753	G-X-G motif; other site
1195464008754	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1195464008755	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1195464008756	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1195464008757	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1195464008758	MgtC family; Region: MgtC; pfam02308
1195464008759	Predicted acetyltransferase [General function prediction only]; Region: COG3981
1195464008760	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464008761	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1195464008762	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1195464008763	putative metal binding site [ion binding]; other site
1195464008764	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464008765	active site
1195464008766	VanW like protein; Region: VanW; pfam04294
1195464008767	Sensor protein DegS; Region: DegS; pfam05384
1195464008768	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
1195464008769	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
1195464008770	exonuclease; Provisional; Region: PRK06722
1195464008771	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1195464008772	active site
1195464008773	catalytic site [active]
1195464008774	substrate binding site [chemical binding]; other site
1195464008775	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1195464008776	DNA-binding site [nucleotide binding]; DNA binding site
1195464008777	RNA-binding motif; other site
1195464008778	flavodoxin; Provisional; Region: PRK06703
1195464008779	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
1195464008780	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464008781	nudix motif; other site
1195464008782	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
1195464008783	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1195464008784	trimer interface [polypeptide binding]; other site
1195464008785	active site
1195464008786	substrate binding site [chemical binding]; other site
1195464008787	CoA binding site [chemical binding]; other site
1195464008788	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008789	Domain of unknown function DUF11; Region: DUF11; cl17728
1195464008790	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008791	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008792	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008793	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008794	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008795	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008796	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008797	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008798	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008799	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008800	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008801	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008802	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1195464008803	short chain dehydrogenase; Provisional; Region: PRK06924
1195464008804	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
1195464008805	NADP binding site [chemical binding]; other site
1195464008806	homodimer interface [polypeptide binding]; other site
1195464008807	active site
1195464008808	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1195464008809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464008810	argininosuccinate lyase; Provisional; Region: PRK06705
1195464008811	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1195464008812	active sites [active]
1195464008813	tetramer interface [polypeptide binding]; other site
1195464008814	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464008815	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1195464008816	active site
1195464008817	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1195464008818	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1195464008819	Na binding site [ion binding]; other site
1195464008820	Protein of unknown function (DUF997); Region: DUF997; pfam06196
1195464008821	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1195464008822	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1195464008823	NAD(P) binding site [chemical binding]; other site
1195464008824	catalytic residues [active]
1195464008825	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1195464008826	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1195464008827	NAD(P) binding site [chemical binding]; other site
1195464008828	homotetramer interface [polypeptide binding]; other site
1195464008829	homodimer interface [polypeptide binding]; other site
1195464008830	active site
1195464008831	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1195464008832	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1195464008833	Divergent PAP2 family; Region: DUF212; pfam02681
1195464008834	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1195464008835	EamA-like transporter family; Region: EamA; pfam00892
1195464008836	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1195464008837	Domain of unknown function DUF59; Region: DUF59; pfam01883
1195464008838	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1195464008839	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1195464008840	Walker A motif; other site
1195464008841	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1195464008842	MoaE interaction surface [polypeptide binding]; other site
1195464008843	MoeB interaction surface [polypeptide binding]; other site
1195464008844	thiocarboxylated glycine; other site
1195464008845	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1195464008846	MoaE homodimer interface [polypeptide binding]; other site
1195464008847	MoaD interaction [polypeptide binding]; other site
1195464008848	active site residues [active]
1195464008849	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1195464008850	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1195464008851	dimer interface [polypeptide binding]; other site
1195464008852	putative functional site; other site
1195464008853	putative MPT binding site; other site
1195464008854	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1195464008855	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1195464008856	ATP binding site [chemical binding]; other site
1195464008857	substrate interface [chemical binding]; other site
1195464008858	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1195464008859	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1195464008860	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464008861	FeS/SAM binding site; other site
1195464008862	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1195464008863	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1195464008864	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1195464008865	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1195464008866	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1195464008867	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1195464008868	catalytic loop [active]
1195464008869	iron binding site [ion binding]; other site
1195464008870	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1195464008871	4Fe-4S binding domain; Region: Fer4; pfam00037
1195464008872	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1195464008873	[4Fe-4S] binding site [ion binding]; other site
1195464008874	molybdopterin cofactor binding site; other site
1195464008875	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1195464008876	molybdopterin cofactor binding site; other site
1195464008877	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464008878	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
1195464008879	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464008880	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464008881	amino acid transporter; Region: 2A0306; TIGR00909
1195464008882	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1195464008883	Tubulin like; Region: Tubulin_2; pfam13809
1195464008884	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1195464008885	metal ion-dependent adhesion site (MIDAS); other site
1195464008886	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
1195464008887	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464008888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464008889	S-adenosylmethionine binding site [chemical binding]; other site
1195464008890	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464008891	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464008892	peptide binding site [polypeptide binding]; other site
1195464008893	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464008894	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464008895	peptide binding site [polypeptide binding]; other site
1195464008896	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464008897	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464008898	peptide binding site [polypeptide binding]; other site
1195464008899	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1195464008900	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1195464008901	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1195464008902	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1195464008903	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1195464008904	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464008905	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464008906	DNA binding residues [nucleotide binding]
1195464008907	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464008908	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464008909	Walker A/P-loop; other site
1195464008910	ATP binding site [chemical binding]; other site
1195464008911	Q-loop/lid; other site
1195464008912	ABC transporter signature motif; other site
1195464008913	Walker B; other site
1195464008914	D-loop; other site
1195464008915	H-loop/switch region; other site
1195464008916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464008917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464008918	putative oxidoreductase; Provisional; Region: PRK11579
1195464008919	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1195464008920	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1195464008921	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1195464008922	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1195464008923	CAP-like domain; other site
1195464008924	active site
1195464008925	primary dimer interface [polypeptide binding]; other site
1195464008926	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464008927	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464008928	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464008929	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1195464008930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464008931	ATP binding site [chemical binding]; other site
1195464008932	Mg2+ binding site [ion binding]; other site
1195464008933	G-X-G motif; other site
1195464008934	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1195464008935	anchoring element; other site
1195464008936	dimer interface [polypeptide binding]; other site
1195464008937	ATP binding site [chemical binding]; other site
1195464008938	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1195464008939	active site
1195464008940	putative metal-binding site [ion binding]; other site
1195464008941	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1195464008942	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1195464008943	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1195464008944	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1195464008945	protein binding site [polypeptide binding]; other site
1195464008946	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464008947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464008948	active site
1195464008949	phosphorylation site [posttranslational modification]
1195464008950	intermolecular recognition site; other site
1195464008951	dimerization interface [polypeptide binding]; other site
1195464008952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464008953	DNA binding site [nucleotide binding]
1195464008954	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1195464008955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464008956	FeS/SAM binding site; other site
1195464008957	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
1195464008958	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1195464008959	effector binding site; other site
1195464008960	active site
1195464008961	Zn binding site [ion binding]; other site
1195464008962	glycine loop; other site
1195464008963	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1195464008964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
1195464008965	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1195464008966	active site
1195464008967	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1195464008968	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464008969	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464008970	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1195464008971	active site
1195464008972	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
1195464008973	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
1195464008974	DNA polymerase III subunit epsilon; Validated; Region: PRK06807
1195464008975	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1195464008976	active site
1195464008977	catalytic site [active]
1195464008978	substrate binding site [chemical binding]; other site
1195464008979	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1195464008980	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1195464008981	catalytic residues [active]
1195464008982	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464008983	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464008984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464008985	Walker A/P-loop; other site
1195464008986	ATP binding site [chemical binding]; other site
1195464008987	Q-loop/lid; other site
1195464008988	ABC transporter signature motif; other site
1195464008989	Walker B; other site
1195464008990	D-loop; other site
1195464008991	H-loop/switch region; other site
1195464008992	aconitate hydratase; Validated; Region: PRK09277
1195464008993	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1195464008994	substrate binding site [chemical binding]; other site
1195464008995	ligand binding site [chemical binding]; other site
1195464008996	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1195464008997	substrate binding site [chemical binding]; other site
1195464008998	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
1195464008999	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464009000	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1195464009001	NodB motif; other site
1195464009002	active site
1195464009003	catalytic site [active]
1195464009004	metal binding site [ion binding]; metal-binding site
1195464009005	Small acid-soluble spore protein P family; Region: SspP; cl12105
1195464009006	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1195464009007	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1195464009008	putative dimer interface [polypeptide binding]; other site
1195464009009	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464009010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464009011	putative substrate translocation pore; other site
1195464009012	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1195464009013	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1195464009014	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1195464009015	nudix motif; other site
1195464009016	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
1195464009017	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1195464009018	dimer interface [polypeptide binding]; other site
1195464009019	active site
1195464009020	acyl-CoA synthetase; Validated; Region: PRK07638
1195464009021	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1195464009022	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1195464009023	acyl-activating enzyme (AAE) consensus motif; other site
1195464009024	acyl-activating enzyme (AAE) consensus motif; other site
1195464009025	AMP binding site [chemical binding]; other site
1195464009026	active site
1195464009027	CoA binding site [chemical binding]; other site
1195464009028	BioY family; Region: BioY; pfam02632
1195464009029	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1195464009030	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1195464009031	dimer interface [polypeptide binding]; other site
1195464009032	acyl-activating enzyme (AAE) consensus motif; other site
1195464009033	putative active site [active]
1195464009034	AMP binding site [chemical binding]; other site
1195464009035	putative CoA binding site [chemical binding]; other site
1195464009036	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464009037	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464009038	non-specific DNA binding site [nucleotide binding]; other site
1195464009039	salt bridge; other site
1195464009040	sequence-specific DNA binding site [nucleotide binding]; other site
1195464009041	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464009042	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464009043	Coenzyme A binding pocket [chemical binding]; other site
1195464009044	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
1195464009045	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464009046	amidase catalytic site [active]
1195464009047	Zn binding residues [ion binding]; other site
1195464009048	substrate binding site [chemical binding]; other site
1195464009049	active site
1195464009050	Protein phosphatase 2C; Region: PP2C_2; pfam13672
1195464009051	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464009052	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464009053	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464009054	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1195464009055	dimer interface [polypeptide binding]; other site
1195464009056	putative metal binding site [ion binding]; other site
1195464009057	PAS domain S-box; Region: sensory_box; TIGR00229
1195464009058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464009059	putative active site [active]
1195464009060	heme pocket [chemical binding]; other site
1195464009061	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1195464009062	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464009063	putative active site [active]
1195464009064	heme pocket [chemical binding]; other site
1195464009065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464009066	dimer interface [polypeptide binding]; other site
1195464009067	phosphorylation site [posttranslational modification]
1195464009068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464009069	ATP binding site [chemical binding]; other site
1195464009070	Mg2+ binding site [ion binding]; other site
1195464009071	G-X-G motif; other site
1195464009072	Predicted esterase [General function prediction only]; Region: COG0400
1195464009073	putative hydrolase; Provisional; Region: PRK11460
1195464009074	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1195464009075	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464009076	Zn binding site [ion binding]; other site
1195464009077	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1195464009078	Zn binding site [ion binding]; other site
1195464009079	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1195464009080	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1195464009081	active site
1195464009082	FMN binding site [chemical binding]; other site
1195464009083	substrate binding site [chemical binding]; other site
1195464009084	3Fe-4S cluster binding site [ion binding]; other site
1195464009085	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1195464009086	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1195464009087	FMN binding site [chemical binding]; other site
1195464009088	active site
1195464009089	substrate binding site [chemical binding]; other site
1195464009090	catalytic residue [active]
1195464009091	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1195464009092	agmatinase; Region: agmatinase; TIGR01230
1195464009093	Agmatinase-like family; Region: Agmatinase-like; cd09990
1195464009094	active site
1195464009095	oligomer interface [polypeptide binding]; other site
1195464009096	Mn binding site [ion binding]; other site
1195464009097	imidazolonepropionase; Validated; Region: PRK09356
1195464009098	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1195464009099	active site
1195464009100	urocanate hydratase; Provisional; Region: PRK05414
1195464009101	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1195464009102	active sites [active]
1195464009103	tetramer interface [polypeptide binding]; other site
1195464009104	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
1195464009105	hexamer interface [polypeptide binding]; other site
1195464009106	RNA binding site [nucleotide binding]; other site
1195464009107	Histidine-zinc binding site [chemical binding]; other site
1195464009108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464009109	DJ-1 family protein; Region: not_thiJ; TIGR01383
1195464009110	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1195464009111	conserved cys residue [active]
1195464009112	AAA domain; Region: AAA_28; pfam13521
1195464009113	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1195464009114	active site
1195464009115	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
1195464009116	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1195464009117	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1195464009118	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1195464009119	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464009120	EamA-like transporter family; Region: EamA; pfam00892
1195464009121	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1195464009122	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464009123	metal binding site [ion binding]; metal-binding site
1195464009124	dimer interface [polypeptide binding]; other site
1195464009125	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1195464009126	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1195464009127	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464009128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464009129	Walker A/P-loop; other site
1195464009130	ATP binding site [chemical binding]; other site
1195464009131	Q-loop/lid; other site
1195464009132	ABC transporter signature motif; other site
1195464009133	Walker B; other site
1195464009134	D-loop; other site
1195464009135	H-loop/switch region; other site
1195464009136	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1195464009137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464009138	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
1195464009139	putative dimerization interface [polypeptide binding]; other site
1195464009140	putative substrate binding pocket [chemical binding]; other site
1195464009141	holin-like protein; Validated; Region: PRK01658
1195464009142	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1195464009143	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1195464009144	nudix motif; other site
1195464009145	Domain of unknown function (DUF3903); Region: DUF3903; pfam13043
1195464009146	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464009147	Nuclease-related domain; Region: NERD; pfam08378
1195464009148	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1195464009149	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1195464009150	active site
1195464009151	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1195464009152	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1195464009153	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464009154	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464009155	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1195464009156	Walker A/P-loop; other site
1195464009157	ATP binding site [chemical binding]; other site
1195464009158	Q-loop/lid; other site
1195464009159	ABC transporter signature motif; other site
1195464009160	Walker B; other site
1195464009161	D-loop; other site
1195464009162	H-loop/switch region; other site
1195464009163	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464009164	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1195464009165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464009166	Walker A/P-loop; other site
1195464009167	ATP binding site [chemical binding]; other site
1195464009168	Q-loop/lid; other site
1195464009169	ABC transporter signature motif; other site
1195464009170	Walker B; other site
1195464009171	D-loop; other site
1195464009172	H-loop/switch region; other site
1195464009173	hypothetical protein; Provisional; Region: PRK01844
1195464009174	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
1195464009175	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1195464009176	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1195464009177	TPP-binding site [chemical binding]; other site
1195464009178	dimer interface [polypeptide binding]; other site
1195464009179	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1195464009180	PYR/PP interface [polypeptide binding]; other site
1195464009181	dimer interface [polypeptide binding]; other site
1195464009182	TPP binding site [chemical binding]; other site
1195464009183	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464009184	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1195464009185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464009186	dimer interface [polypeptide binding]; other site
1195464009187	conserved gate region; other site
1195464009188	ABC-ATPase subunit interface; other site
1195464009189	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1195464009190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464009191	dimer interface [polypeptide binding]; other site
1195464009192	conserved gate region; other site
1195464009193	ABC-ATPase subunit interface; other site
1195464009194	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1195464009195	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1195464009196	Walker A/P-loop; other site
1195464009197	ATP binding site [chemical binding]; other site
1195464009198	Q-loop/lid; other site
1195464009199	ABC transporter signature motif; other site
1195464009200	Walker B; other site
1195464009201	D-loop; other site
1195464009202	H-loop/switch region; other site
1195464009203	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1195464009204	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464009205	membrane-bound complex binding site; other site
1195464009206	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1195464009207	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1195464009208	active site
1195464009209	metal binding site [ion binding]; metal-binding site
1195464009210	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1195464009211	hypothetical protein; Provisional; Region: PRK01546
1195464009212	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464009213	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1195464009214	catalytic residues [active]
1195464009215	catalytic nucleophile [active]
1195464009216	LexA repressor; Validated; Region: PRK00215
1195464009217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464009218	putative DNA binding site [nucleotide binding]; other site
1195464009219	putative Zn2+ binding site [ion binding]; other site
1195464009220	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1195464009221	Catalytic site [active]
1195464009222	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1195464009223	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1195464009224	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
1195464009225	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464009226	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464009227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464009228	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464009229	Walker A/P-loop; other site
1195464009230	ATP binding site [chemical binding]; other site
1195464009231	Q-loop/lid; other site
1195464009232	ABC transporter signature motif; other site
1195464009233	Walker B; other site
1195464009234	D-loop; other site
1195464009235	H-loop/switch region; other site
1195464009236	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
1195464009237	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
1195464009238	active site
1195464009239	nucleotide-binding site [chemical binding]; other site
1195464009240	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1195464009241	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
1195464009242	active site
1195464009243	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1195464009244	Ligand Binding Site [chemical binding]; other site
1195464009245	Molecular Tunnel; other site
1195464009246	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1195464009247	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1195464009248	inhibitor-cofactor binding pocket; inhibition site
1195464009249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464009250	catalytic residue [active]
1195464009251	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1195464009252	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1195464009253	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1195464009254	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
1195464009255	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1195464009256	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1195464009257	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1195464009258	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1195464009259	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1195464009260	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1195464009261	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464009262	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1195464009263	putative ADP-binding pocket [chemical binding]; other site
1195464009264	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464009265	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1195464009266	putative ADP-binding pocket [chemical binding]; other site
1195464009267	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464009268	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1195464009269	active site
1195464009270	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1195464009271	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464009272	putative ADP-binding pocket [chemical binding]; other site
1195464009273	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1195464009274	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1195464009275	putative ADP-binding pocket [chemical binding]; other site
1195464009276	CoA-binding domain; Region: CoA_binding_3; pfam13727
1195464009277	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1195464009278	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1195464009279	NAD(P) binding site [chemical binding]; other site
1195464009280	homodimer interface [polypeptide binding]; other site
1195464009281	substrate binding site [chemical binding]; other site
1195464009282	active site
1195464009283	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1195464009284	Chain length determinant protein; Region: Wzz; cl15801
1195464009285	glutamine synthetase, type I; Region: GlnA; TIGR00653
1195464009286	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1195464009287	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1195464009288	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1195464009289	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464009290	DNA binding residues [nucleotide binding]
1195464009291	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1195464009292	Aluminium resistance protein; Region: Alum_res; pfam06838
1195464009293	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1195464009294	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1195464009295	HflX GTPase family; Region: HflX; cd01878
1195464009296	G1 box; other site
1195464009297	GTP/Mg2+ binding site [chemical binding]; other site
1195464009298	Switch I region; other site
1195464009299	G2 box; other site
1195464009300	G3 box; other site
1195464009301	Switch II region; other site
1195464009302	G4 box; other site
1195464009303	G5 box; other site
1195464009304	Predicted membrane protein [Function unknown]; Region: COG2860
1195464009305	UPF0126 domain; Region: UPF0126; pfam03458
1195464009306	UPF0126 domain; Region: UPF0126; pfam03458
1195464009307	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1195464009308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464009309	Walker A motif; other site
1195464009310	ATP binding site [chemical binding]; other site
1195464009311	Walker B motif; other site
1195464009312	arginine finger; other site
1195464009313	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1195464009314	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1195464009315	active site
1195464009316	catalytic residues [active]
1195464009317	DNA binding site [nucleotide binding]
1195464009318	Int/Topo IB signature motif; other site
1195464009319	Protein of unknown function (DUF3982); Region: DUF3982; pfam13138
1195464009320	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1195464009321	Helix-turn-helix domain; Region: HTH_28; pfam13518
1195464009322	Helix-turn-helix domain; Region: HTH_28; pfam13518
1195464009323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1195464009324	HTH-like domain; Region: HTH_21; pfam13276
1195464009325	Integrase core domain; Region: rve; pfam00665
1195464009326	Integrase core domain; Region: rve_2; pfam13333
1195464009327	bacterial Hfq-like; Region: Hfq; cd01716
1195464009328	hexamer interface [polypeptide binding]; other site
1195464009329	Sm1 motif; other site
1195464009330	RNA binding site [nucleotide binding]; other site
1195464009331	Sm2 motif; other site
1195464009332	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1195464009333	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1195464009334	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464009335	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464009336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464009337	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1195464009338	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1195464009339	active site
1195464009340	phosphorylation site [posttranslational modification]
1195464009341	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1195464009342	active site
1195464009343	P-loop; other site
1195464009344	phosphorylation site [posttranslational modification]
1195464009345	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1195464009346	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1195464009347	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1195464009348	putative substrate binding site [chemical binding]; other site
1195464009349	putative ATP binding site [chemical binding]; other site
1195464009350	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1195464009351	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1195464009352	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1195464009353	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1195464009354	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1195464009355	dimer interface [polypeptide binding]; other site
1195464009356	active site
1195464009357	metal binding site [ion binding]; metal-binding site
1195464009358	Predicted membrane protein [Function unknown]; Region: COG2322
1195464009359	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1195464009360	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
1195464009361	Glyco_18 domain; Region: Glyco_18; smart00636
1195464009362	putative active site [active]
1195464009363	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464009364	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1195464009365	metal binding site [ion binding]; metal-binding site
1195464009366	dimer interface [polypeptide binding]; other site
1195464009367	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1195464009368	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464009369	putative active site [active]
1195464009370	putative metal binding site [ion binding]; other site
1195464009371	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1195464009372	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1195464009373	IHF dimer interface [polypeptide binding]; other site
1195464009374	IHF - DNA interface [nucleotide binding]; other site
1195464009375	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464009376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464009377	Coenzyme A binding pocket [chemical binding]; other site
1195464009378	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1195464009379	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1195464009380	metal-binding site [ion binding]
1195464009381	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1195464009382	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1195464009383	metal-binding site [ion binding]
1195464009384	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464009385	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1195464009386	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1195464009387	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1195464009388	metal-binding site [ion binding]
1195464009389	Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157
1195464009390	putative homodimer interface [polypeptide binding]; other site
1195464009391	putative homotetramer interface [polypeptide binding]; other site
1195464009392	allosteric switch controlling residues; other site
1195464009393	putative metal binding site [ion binding]; other site
1195464009394	putative homodimer-homodimer interface [polypeptide binding]; other site
1195464009395	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464009396	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464009397	DNA binding residues [nucleotide binding]
1195464009398	dimerization interface [polypeptide binding]; other site
1195464009399	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464009400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464009401	S-adenosylmethionine binding site [chemical binding]; other site
1195464009402	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1195464009403	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1195464009404	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1195464009405	Walker A/P-loop; other site
1195464009406	ATP binding site [chemical binding]; other site
1195464009407	Q-loop/lid; other site
1195464009408	ABC transporter signature motif; other site
1195464009409	Walker B; other site
1195464009410	D-loop; other site
1195464009411	H-loop/switch region; other site
1195464009412	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464009413	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464009414	ABC-ATPase subunit  interface; other site
1195464009415	dimer interface [polypeptide binding]; other site
1195464009416	putative PBP binding regions; other site
1195464009417	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464009418	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464009419	ABC-ATPase subunit  interface; other site
1195464009420	dimer interface [polypeptide binding]; other site
1195464009421	putative PBP binding regions; other site
1195464009422	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1195464009423	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1195464009424	putative ligand binding residues [chemical binding]; other site
1195464009425	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1195464009426	active site
1195464009427	putative catalytic site [active]
1195464009428	DNA binding site [nucleotide binding]
1195464009429	putative phosphate binding site [ion binding]; other site
1195464009430	metal binding site A [ion binding]; metal-binding site
1195464009431	AP binding site [nucleotide binding]; other site
1195464009432	metal binding site B [ion binding]; metal-binding site
1195464009433	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1195464009434	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1195464009435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464009436	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464009437	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1195464009438	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1195464009439	DNA binding site [nucleotide binding]
1195464009440	active site
1195464009441	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
1195464009442	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1195464009443	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1195464009444	minor groove reading motif; other site
1195464009445	helix-hairpin-helix signature motif; other site
1195464009446	substrate binding pocket [chemical binding]; other site
1195464009447	active site
1195464009448	peptidase T; Region: peptidase-T; TIGR01882
1195464009449	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1195464009450	metal binding site [ion binding]; metal-binding site
1195464009451	dimer interface [polypeptide binding]; other site
1195464009452	Predicted membrane protein [Function unknown]; Region: COG2364
1195464009453	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464009454	hypothetical protein; Provisional; Region: PRK06764
1195464009455	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464009456	catalytic core [active]
1195464009457	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1195464009458	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1195464009459	PAS domain S-box; Region: sensory_box; TIGR00229
1195464009460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464009461	putative active site [active]
1195464009462	heme pocket [chemical binding]; other site
1195464009463	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464009464	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464009465	metal binding site [ion binding]; metal-binding site
1195464009466	active site
1195464009467	I-site; other site
1195464009468	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464009469	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1195464009470	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1195464009471	active site
1195464009472	homodimer interface [polypeptide binding]; other site
1195464009473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464009474	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1195464009475	NAD(P) binding site [chemical binding]; other site
1195464009476	active site
1195464009477	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1195464009478	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1195464009479	NAD(P) binding site [chemical binding]; other site
1195464009480	homodimer interface [polypeptide binding]; other site
1195464009481	substrate binding site [chemical binding]; other site
1195464009482	active site
1195464009483	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1195464009484	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
1195464009485	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1195464009486	holin-like protein; Validated; Region: PRK01658
1195464009487	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464009488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464009489	DNA-binding site [nucleotide binding]; DNA binding site
1195464009490	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464009491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464009492	homodimer interface [polypeptide binding]; other site
1195464009493	catalytic residue [active]
1195464009494	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464009495	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1195464009496	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1195464009497	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1195464009498	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464009499	DNA-binding site [nucleotide binding]; DNA binding site
1195464009500	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1195464009501	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1195464009502	beta-galactosidase; Region: BGL; TIGR03356
1195464009503	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
1195464009504	active site
1195464009505	catalytic site [active]
1195464009506	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
1195464009507	putative active site [active]
1195464009508	putative catalytic triad [active]
1195464009509	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1195464009510	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464009511	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1195464009512	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464009513	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1195464009514	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1195464009515	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1195464009516	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1195464009517	Sulfatase; Region: Sulfatase; pfam00884
1195464009518	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1195464009519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464009520	binding surface
1195464009521	TPR motif; other site
1195464009522	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1195464009523	G1 box; other site
1195464009524	GTP/Mg2+ binding site [chemical binding]; other site
1195464009525	Switch I region; other site
1195464009526	G3 box; other site
1195464009527	Switch II region; other site
1195464009528	G4 box; other site
1195464009529	G5 box; other site
1195464009530	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1195464009531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464009532	ATP binding site [chemical binding]; other site
1195464009533	Mg2+ binding site [ion binding]; other site
1195464009534	G-X-G motif; other site
1195464009535	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1195464009536	ATP binding site [chemical binding]; other site
1195464009537	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1195464009538	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1195464009539	MutS domain I; Region: MutS_I; pfam01624
1195464009540	MutS domain II; Region: MutS_II; pfam05188
1195464009541	MutS domain III; Region: MutS_III; pfam05192
1195464009542	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1195464009543	Walker A/P-loop; other site
1195464009544	ATP binding site [chemical binding]; other site
1195464009545	Q-loop/lid; other site
1195464009546	ABC transporter signature motif; other site
1195464009547	Walker B; other site
1195464009548	D-loop; other site
1195464009549	H-loop/switch region; other site
1195464009550	Outer spore coat protein E (CotE); Region: CotE; pfam10628
1195464009551	Predicted membrane protein [Function unknown]; Region: COG4550
1195464009552	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1195464009553	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1195464009554	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464009555	FeS/SAM binding site; other site
1195464009556	TRAM domain; Region: TRAM; pfam01938
1195464009557	2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177
1195464009558	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1195464009559	TPP-binding site [chemical binding]; other site
1195464009560	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1195464009561	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1195464009562	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1195464009563	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1195464009564	dimer interface [polypeptide binding]; other site
1195464009565	PYR/PP interface [polypeptide binding]; other site
1195464009566	TPP binding site [chemical binding]; other site
1195464009567	substrate binding site [chemical binding]; other site
1195464009568	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464009569	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1195464009570	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1195464009571	active site
1195464009572	dimer interface [polypeptide binding]; other site
1195464009573	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1195464009574	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1195464009575	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464009576	putative active site [active]
1195464009577	metal binding site [ion binding]; metal-binding site
1195464009578	homodimer binding site [polypeptide binding]; other site
1195464009579	phosphodiesterase; Provisional; Region: PRK12704
1195464009580	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464009581	Zn2+ binding site [ion binding]; other site
1195464009582	Mg2+ binding site [ion binding]; other site
1195464009583	recA bacterial DNA recombination protein; Region: RecA; cl17211
1195464009584	recA bacterial DNA recombination protein; Region: RecA; cl17211
1195464009585	competence damage-inducible protein A; Provisional; Region: PRK00549
1195464009586	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1195464009587	putative MPT binding site; other site
1195464009588	Competence-damaged protein; Region: CinA; pfam02464
1195464009589	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1195464009590	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464009591	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464009592	non-specific DNA binding site [nucleotide binding]; other site
1195464009593	salt bridge; other site
1195464009594	sequence-specific DNA binding site [nucleotide binding]; other site
1195464009595	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1195464009596	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1195464009597	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1195464009598	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1195464009599	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1195464009600	classical (c) SDRs; Region: SDR_c; cd05233
1195464009601	NAD(P) binding site [chemical binding]; other site
1195464009602	active site
1195464009603	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1195464009604	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1195464009605	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1195464009606	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1195464009607	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1195464009608	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464009609	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1195464009610	TM-ABC transporter signature motif; other site
1195464009611	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464009612	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1195464009613	TM-ABC transporter signature motif; other site
1195464009614	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1195464009615	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1195464009616	Walker A/P-loop; other site
1195464009617	ATP binding site [chemical binding]; other site
1195464009618	Q-loop/lid; other site
1195464009619	ABC transporter signature motif; other site
1195464009620	Walker B; other site
1195464009621	D-loop; other site
1195464009622	H-loop/switch region; other site
1195464009623	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1195464009624	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1195464009625	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1195464009626	ligand binding site [chemical binding]; other site
1195464009627	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464009628	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1195464009629	DNA-binding site [nucleotide binding]; DNA binding site
1195464009630	UTRA domain; Region: UTRA; pfam07702
1195464009631	Tetraspanin family; Region: Tetraspannin; pfam00335
1195464009632	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1195464009633	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464009634	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1195464009635	YlzJ-like protein; Region: YlzJ; pfam14035
1195464009636	Clp protease; Region: CLP_protease; pfam00574
1195464009637	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1195464009638	active site
1195464009639	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1195464009640	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464009641	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1195464009642	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1195464009643	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1195464009644	dimer interface [polypeptide binding]; other site
1195464009645	active site
1195464009646	catalytic residue [active]
1195464009647	aspartate kinase I; Reviewed; Region: PRK08210
1195464009648	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1195464009649	nucleotide binding site [chemical binding]; other site
1195464009650	substrate binding site [chemical binding]; other site
1195464009651	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1195464009652	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
1195464009653	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1195464009654	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1195464009655	Flavoprotein; Region: Flavoprotein; cl08021
1195464009656	DNA polymerase IV; Reviewed; Region: PRK03103
1195464009657	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1195464009658	active site
1195464009659	DNA binding site [nucleotide binding]
1195464009660	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1195464009661	YolD-like protein; Region: YolD; pfam08863
1195464009662	YolD-like protein; Region: YolD; pfam08863
1195464009663	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464009664	amidase catalytic site [active]
1195464009665	Zn binding residues [ion binding]; other site
1195464009666	substrate binding site [chemical binding]; other site
1195464009667	Bacterial SH3 domain; Region: SH3_3; cl17532
1195464009668	Haemolysin XhlA; Region: XhlA; pfam10779
1195464009669	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1195464009670	putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633
1195464009671	Phage tail protein; Region: Sipho_tail; cl17486
1195464009672	Phage-related minor tail protein [Function unknown]; Region: COG5280
1195464009673	Phage-related protein [Function unknown]; Region: COG5412
1195464009674	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1195464009675	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1195464009676	Phage capsid family; Region: Phage_capsid; pfam05065
1195464009677	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1195464009678	oligomer interface [polypeptide binding]; other site
1195464009679	active site residues [active]
1195464009680	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1195464009681	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1195464009682	Phage terminase, small subunit; Region: Terminase_4; cl01525
1195464009683	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1195464009684	HNH endonuclease; Region: HNH; pfam01844
1195464009685	active site
1195464009686	Cytochrome P450; Region: p450; cl12078
1195464009687	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464009688	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464009689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464009690	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464009691	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464009692	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464009693	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464009694	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1195464009695	Int/Topo IB signature motif; other site
1195464009696	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464009697	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
1195464009698	replicative DNA helicase; Provisional; Region: PRK06749
1195464009699	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1195464009700	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1195464009701	Walker A motif; other site
1195464009702	ATP binding site [chemical binding]; other site
1195464009703	Walker B motif; other site
1195464009704	DNA binding loops [nucleotide binding]
1195464009705	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1195464009706	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464009707	non-specific DNA binding site [nucleotide binding]; other site
1195464009708	salt bridge; other site
1195464009709	sequence-specific DNA binding site [nucleotide binding]; other site
1195464009710	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464009711	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464009712	non-specific DNA binding site [nucleotide binding]; other site
1195464009713	salt bridge; other site
1195464009714	sequence-specific DNA binding site [nucleotide binding]; other site
1195464009715	Domain of unknown function (DUF955); Region: DUF955; cl01076
1195464009716	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1195464009717	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1195464009718	catalytic residues [active]
1195464009719	catalytic nucleophile [active]
1195464009720	Recombinase; Region: Recombinase; pfam07508
1195464009721	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1195464009722	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1195464009723	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1195464009724	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1195464009725	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1195464009726	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1195464009727	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1195464009728	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1195464009729	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
1195464009730	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1195464009731	NodB motif; other site
1195464009732	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1195464009733	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1195464009734	RNase E interface [polypeptide binding]; other site
1195464009735	trimer interface [polypeptide binding]; other site
1195464009736	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1195464009737	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1195464009738	RNase E interface [polypeptide binding]; other site
1195464009739	trimer interface [polypeptide binding]; other site
1195464009740	active site
1195464009741	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1195464009742	putative nucleic acid binding region [nucleotide binding]; other site
1195464009743	G-X-X-G motif; other site
1195464009744	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1195464009745	RNA binding site [nucleotide binding]; other site
1195464009746	domain interface; other site
1195464009747	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1195464009748	16S/18S rRNA binding site [nucleotide binding]; other site
1195464009749	S13e-L30e interaction site [polypeptide binding]; other site
1195464009750	25S rRNA binding site [nucleotide binding]; other site
1195464009751	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1195464009752	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1195464009753	active site
1195464009754	Riboflavin kinase; Region: Flavokinase; pfam01687
1195464009755	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1195464009756	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1195464009757	RNA binding site [nucleotide binding]; other site
1195464009758	active site
1195464009759	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1195464009760	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1195464009761	translation initiation factor IF-2; Region: IF-2; TIGR00487
1195464009762	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1195464009763	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1195464009764	G1 box; other site
1195464009765	putative GEF interaction site [polypeptide binding]; other site
1195464009766	GTP/Mg2+ binding site [chemical binding]; other site
1195464009767	Switch I region; other site
1195464009768	G2 box; other site
1195464009769	G3 box; other site
1195464009770	Switch II region; other site
1195464009771	G4 box; other site
1195464009772	G5 box; other site
1195464009773	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1195464009774	Translation-initiation factor 2; Region: IF-2; pfam11987
1195464009775	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1195464009776	hypothetical protein; Provisional; Region: PRK07714
1195464009777	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1195464009778	putative RNA binding cleft [nucleotide binding]; other site
1195464009779	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1195464009780	NusA N-terminal domain; Region: NusA_N; pfam08529
1195464009781	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1195464009782	RNA binding site [nucleotide binding]; other site
1195464009783	homodimer interface [polypeptide binding]; other site
1195464009784	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1195464009785	G-X-X-G motif; other site
1195464009786	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1195464009787	G-X-X-G motif; other site
1195464009788	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1195464009789	Sm and related proteins; Region: Sm_like; cl00259
1195464009790	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1195464009791	putative oligomer interface [polypeptide binding]; other site
1195464009792	putative RNA binding site [nucleotide binding]; other site
1195464009793	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1195464009794	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1195464009795	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1195464009796	generic binding surface II; other site
1195464009797	generic binding surface I; other site
1195464009798	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1195464009799	active site
1195464009800	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1195464009801	active site
1195464009802	catalytic site [active]
1195464009803	substrate binding site [chemical binding]; other site
1195464009804	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1195464009805	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1195464009806	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1195464009807	dimer interface [polypeptide binding]; other site
1195464009808	motif 1; other site
1195464009809	active site
1195464009810	motif 2; other site
1195464009811	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1195464009812	putative deacylase active site [active]
1195464009813	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1195464009814	active site
1195464009815	motif 3; other site
1195464009816	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1195464009817	anticodon binding site; other site
1195464009818	RIP metalloprotease RseP; Region: TIGR00054
1195464009819	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1195464009820	active site
1195464009821	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1195464009822	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1195464009823	protein binding site [polypeptide binding]; other site
1195464009824	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1195464009825	putative substrate binding region [chemical binding]; other site
1195464009826	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1195464009827	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1195464009828	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1195464009829	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1195464009830	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1195464009831	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1195464009832	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1195464009833	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1195464009834	catalytic residue [active]
1195464009835	putative FPP diphosphate  binding site; other site
1195464009836	putative FPP binding hydrophobic cleft; other site
1195464009837	dimer interface [polypeptide binding]; other site
1195464009838	putative IPP diphosphate binding site; other site
1195464009839	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1195464009840	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1195464009841	hinge region; other site
1195464009842	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1195464009843	putative nucleotide binding site [chemical binding]; other site
1195464009844	uridine monophosphate binding site [chemical binding]; other site
1195464009845	homohexameric interface [polypeptide binding]; other site
1195464009846	elongation factor Ts; Provisional; Region: tsf; PRK09377
1195464009847	UBA/TS-N domain; Region: UBA; pfam00627
1195464009848	Elongation factor TS; Region: EF_TS; pfam00889
1195464009849	Elongation factor TS; Region: EF_TS; pfam00889
1195464009850	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1195464009851	rRNA interaction site [nucleotide binding]; other site
1195464009852	S8 interaction site; other site
1195464009853	putative laminin-1 binding site; other site
1195464009854	transcriptional repressor CodY; Validated; Region: PRK04158
1195464009855	CodY GAF-like domain; Region: CodY; pfam06018
1195464009856	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1195464009857	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1195464009858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464009859	Walker A motif; other site
1195464009860	ATP binding site [chemical binding]; other site
1195464009861	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1195464009862	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1195464009863	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1195464009864	active site
1195464009865	HslU subunit interaction site [polypeptide binding]; other site
1195464009866	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1195464009867	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1195464009868	active site
1195464009869	Int/Topo IB signature motif; other site
1195464009870	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1195464009871	Glucose inhibited division protein A; Region: GIDA; pfam01134
1195464009872	DNA topoisomerase I; Validated; Region: PRK05582
1195464009873	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1195464009874	active site
1195464009875	metal binding site [ion binding]; metal-binding site
1195464009876	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464009877	domain I; other site
1195464009878	DNA binding groove [nucleotide binding]
1195464009879	phosphate binding site [ion binding]; other site
1195464009880	domain II; other site
1195464009881	domain III; other site
1195464009882	nucleotide binding site [chemical binding]; other site
1195464009883	catalytic site [active]
1195464009884	domain IV; other site
1195464009885	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464009886	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1195464009887	DNA protecting protein DprA; Region: dprA; TIGR00732
1195464009888	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1195464009889	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1195464009890	CoA binding domain; Region: CoA_binding; smart00881
1195464009891	CoA-ligase; Region: Ligase_CoA; pfam00549
1195464009892	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1195464009893	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1195464009894	CoA-ligase; Region: Ligase_CoA; pfam00549
1195464009895	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1195464009896	RNA/DNA hybrid binding site [nucleotide binding]; other site
1195464009897	active site
1195464009898	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1195464009899	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1195464009900	GTP/Mg2+ binding site [chemical binding]; other site
1195464009901	G4 box; other site
1195464009902	G5 box; other site
1195464009903	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
1195464009904	G1 box; other site
1195464009905	G1 box; other site
1195464009906	GTP/Mg2+ binding site [chemical binding]; other site
1195464009907	Switch I region; other site
1195464009908	G2 box; other site
1195464009909	G2 box; other site
1195464009910	G3 box; other site
1195464009911	G3 box; other site
1195464009912	Switch II region; other site
1195464009913	Switch II region; other site
1195464009914	G4 box; other site
1195464009915	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1195464009916	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464009917	Catalytic site [active]
1195464009918	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464009919	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1195464009920	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1195464009921	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1195464009922	RimM N-terminal domain; Region: RimM; pfam01782
1195464009923	PRC-barrel domain; Region: PRC; pfam05239
1195464009924	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1195464009925	KH domain; Region: KH_4; pfam13083
1195464009926	G-X-X-G motif; other site
1195464009927	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1195464009928	signal recognition particle protein; Provisional; Region: PRK10867
1195464009929	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1195464009930	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1195464009931	P loop; other site
1195464009932	GTP binding site [chemical binding]; other site
1195464009933	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1195464009934	putative DNA-binding protein; Validated; Region: PRK00118
1195464009935	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1195464009936	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1195464009937	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1195464009938	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1195464009939	P loop; other site
1195464009940	GTP binding site [chemical binding]; other site
1195464009941	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1195464009942	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1195464009943	Walker A/P-loop; other site
1195464009944	ATP binding site [chemical binding]; other site
1195464009945	Q-loop/lid; other site
1195464009946	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1195464009947	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1195464009948	ABC transporter signature motif; other site
1195464009949	Walker B; other site
1195464009950	D-loop; other site
1195464009951	H-loop/switch region; other site
1195464009952	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1195464009953	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1195464009954	dimerization interface [polypeptide binding]; other site
1195464009955	active site
1195464009956	metal binding site [ion binding]; metal-binding site
1195464009957	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1195464009958	dsRNA binding site [nucleotide binding]; other site
1195464009959	acyl carrier protein; Provisional; Region: acpP; PRK00982
1195464009960	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1195464009961	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1195464009962	NAD(P) binding site [chemical binding]; other site
1195464009963	homotetramer interface [polypeptide binding]; other site
1195464009964	homodimer interface [polypeptide binding]; other site
1195464009965	active site
1195464009966	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1195464009967	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1195464009968	putative phosphate acyltransferase; Provisional; Region: PRK05331
1195464009969	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1195464009970	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1195464009971	active site 2 [active]
1195464009972	active site 1 [active]
1195464009973	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1195464009974	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1195464009975	generic binding surface II; other site
1195464009976	ssDNA binding site; other site
1195464009977	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464009978	ATP binding site [chemical binding]; other site
1195464009979	putative Mg++ binding site [ion binding]; other site
1195464009980	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464009981	nucleotide binding region [chemical binding]; other site
1195464009982	ATP-binding site [chemical binding]; other site
1195464009983	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1195464009984	DAK2 domain; Region: Dak2; pfam02734
1195464009985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1195464009986	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1195464009987	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1195464009988	Thiamine pyrophosphokinase; Region: TPK; cd07995
1195464009989	active site
1195464009990	dimerization interface [polypeptide binding]; other site
1195464009991	thiamine binding site [chemical binding]; other site
1195464009992	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1195464009993	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1195464009994	substrate binding site [chemical binding]; other site
1195464009995	hexamer interface [polypeptide binding]; other site
1195464009996	metal binding site [ion binding]; metal-binding site
1195464009997	GTPase RsgA; Reviewed; Region: PRK00098
1195464009998	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1195464009999	RNA binding site [nucleotide binding]; other site
1195464010000	homodimer interface [polypeptide binding]; other site
1195464010001	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1195464010002	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1195464010003	GTP/Mg2+ binding site [chemical binding]; other site
1195464010004	G4 box; other site
1195464010005	G5 box; other site
1195464010006	G1 box; other site
1195464010007	Switch I region; other site
1195464010008	G2 box; other site
1195464010009	G3 box; other site
1195464010010	Switch II region; other site
1195464010011	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1195464010012	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1195464010013	active site
1195464010014	ATP binding site [chemical binding]; other site
1195464010015	substrate binding site [chemical binding]; other site
1195464010016	activation loop (A-loop); other site
1195464010017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1195464010018	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1195464010019	PASTA domain; Region: PASTA; pfam03793
1195464010020	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1195464010021	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1195464010022	Protein phosphatase 2C; Region: PP2C; pfam00481
1195464010023	active site
1195464010024	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1195464010025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464010026	FeS/SAM binding site; other site
1195464010027	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1195464010028	NusB family; Region: NusB; pfam01029
1195464010029	putative RNA binding site [nucleotide binding]; other site
1195464010030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464010031	S-adenosylmethionine binding site [chemical binding]; other site
1195464010032	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1195464010033	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1195464010034	putative active site [active]
1195464010035	substrate binding site [chemical binding]; other site
1195464010036	putative cosubstrate binding site; other site
1195464010037	catalytic site [active]
1195464010038	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1195464010039	substrate binding site [chemical binding]; other site
1195464010040	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1195464010041	active site
1195464010042	catalytic residues [active]
1195464010043	metal binding site [ion binding]; metal-binding site
1195464010044	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464010045	primosomal protein N' Region: priA; TIGR00595
1195464010046	ATP binding site [chemical binding]; other site
1195464010047	putative Mg++ binding site [ion binding]; other site
1195464010048	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1195464010049	nucleotide binding region [chemical binding]; other site
1195464010050	ATP-binding site [chemical binding]; other site
1195464010051	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1195464010052	Flavoprotein; Region: Flavoprotein; pfam02441
1195464010053	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1195464010054	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1195464010055	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1195464010056	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1195464010057	catalytic site [active]
1195464010058	G-X2-G-X-G-K; other site
1195464010059	hypothetical protein; Provisional; Region: PRK04323
1195464010060	hypothetical protein; Provisional; Region: PRK11820
1195464010061	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1195464010062	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1195464010063	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1195464010064	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1195464010065	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464010066	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1195464010067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464010068	motif II; other site
1195464010069	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1195464010070	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1195464010071	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1195464010072	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1195464010073	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1195464010074	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1195464010075	active site
1195464010076	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1195464010077	DinB superfamily; Region: DinB_2; pfam12867
1195464010078	YoqO-like protein; Region: YoqO; pfam14037
1195464010079	YoqO-like protein; Region: YoqO; pfam14037
1195464010080	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1195464010081	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
1195464010082	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464010083	active site
1195464010084	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1195464010085	active site
1195464010086	dimer interface [polypeptide binding]; other site
1195464010087	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1195464010088	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1195464010089	heterodimer interface [polypeptide binding]; other site
1195464010090	active site
1195464010091	FMN binding site [chemical binding]; other site
1195464010092	homodimer interface [polypeptide binding]; other site
1195464010093	substrate binding site [chemical binding]; other site
1195464010094	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1195464010095	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1195464010096	FAD binding pocket [chemical binding]; other site
1195464010097	FAD binding motif [chemical binding]; other site
1195464010098	phosphate binding motif [ion binding]; other site
1195464010099	beta-alpha-beta structure motif; other site
1195464010100	NAD binding pocket [chemical binding]; other site
1195464010101	Iron coordination center [ion binding]; other site
1195464010102	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1195464010103	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1195464010104	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1195464010105	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1195464010106	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1195464010107	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1195464010108	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1195464010109	IMP binding site; other site
1195464010110	dimer interface [polypeptide binding]; other site
1195464010111	interdomain contacts; other site
1195464010112	partial ornithine binding site; other site
1195464010113	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1195464010114	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1195464010115	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1195464010116	catalytic site [active]
1195464010117	subunit interface [polypeptide binding]; other site
1195464010118	dihydroorotase; Validated; Region: pyrC; PRK09357
1195464010119	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1195464010120	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1195464010121	active site
1195464010122	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1195464010123	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1195464010124	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1195464010125	uracil transporter; Provisional; Region: PRK10720
1195464010126	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1195464010127	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464010128	active site
1195464010129	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1195464010130	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464010131	RNA binding surface [nucleotide binding]; other site
1195464010132	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1195464010133	active site
1195464010134	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1195464010135	lipoprotein signal peptidase; Provisional; Region: PRK14787
1195464010136	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1195464010137	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1195464010138	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1195464010139	active site
1195464010140	HIGH motif; other site
1195464010141	nucleotide binding site [chemical binding]; other site
1195464010142	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1195464010143	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1195464010144	active site
1195464010145	KMSKS motif; other site
1195464010146	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1195464010147	tRNA binding surface [nucleotide binding]; other site
1195464010148	anticodon binding site; other site
1195464010149	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1195464010150	DivIVA protein; Region: DivIVA; pfam05103
1195464010151	DivIVA domain; Region: DivI1A_domain; TIGR03544
1195464010152	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1195464010153	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1195464010154	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464010155	RNA binding surface [nucleotide binding]; other site
1195464010156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1195464010157	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1195464010158	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1195464010159	catalytic residue [active]
1195464010160	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1195464010161	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1195464010162	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
1195464010163	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1195464010164	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464010165	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464010166	DNA binding residues [nucleotide binding]
1195464010167	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1195464010168	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464010169	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464010170	DNA binding residues [nucleotide binding]
1195464010171	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1195464010172	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1195464010173	cell division protein FtsZ; Validated; Region: PRK09330
1195464010174	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1195464010175	nucleotide binding site [chemical binding]; other site
1195464010176	SulA interaction site; other site
1195464010177	cell division protein FtsA; Region: ftsA; TIGR01174
1195464010178	Cell division protein FtsA; Region: FtsA; smart00842
1195464010179	Cell division protein FtsA; Region: FtsA; pfam14450
1195464010180	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1195464010181	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1195464010182	Cell division protein FtsQ; Region: FtsQ; pfam03799
1195464010183	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1195464010184	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464010185	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1195464010186	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1195464010187	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1195464010188	active site
1195464010189	homodimer interface [polypeptide binding]; other site
1195464010190	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1195464010191	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1195464010192	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1195464010193	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1195464010194	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1195464010195	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1195464010196	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1195464010197	Mg++ binding site [ion binding]; other site
1195464010198	putative catalytic motif [active]
1195464010199	putative substrate binding site [chemical binding]; other site
1195464010200	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1195464010201	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1195464010202	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1195464010203	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1195464010204	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1195464010205	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464010206	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464010207	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
1195464010208	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464010209	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464010210	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464010211	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1195464010212	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1195464010213	Cell division protein FtsL; Region: FtsL; cl11433
1195464010214	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1195464010215	MraW methylase family; Region: Methyltransf_5; pfam01795
1195464010216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1195464010217	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1195464010218	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1195464010219	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1195464010220	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1195464010221	hypothetical protein; Provisional; Region: PRK13688
1195464010222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464010223	Coenzyme A binding pocket [chemical binding]; other site
1195464010224	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1195464010225	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1195464010226	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1195464010227	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1195464010228	Replication-relaxation; Region: Replic_Relax; pfam13814
1195464010229	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464010230	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464010231	non-specific DNA binding site [nucleotide binding]; other site
1195464010232	salt bridge; other site
1195464010233	sequence-specific DNA binding site [nucleotide binding]; other site
1195464010234	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1195464010235	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1195464010236	active site
1195464010237	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
1195464010238	Holin family; Region: Phage_holin_4; pfam05105
1195464010239	Haemolysin XhlA; Region: XhlA; pfam10779
1195464010240	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
1195464010241	Phage tail protein; Region: Sipho_tail; pfam05709
1195464010242	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1195464010243	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1195464010244	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
1195464010245	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
1195464010246	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1195464010247	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1195464010248	oligomerization interface [polypeptide binding]; other site
1195464010249	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
1195464010250	Interdomain contacts; other site
1195464010251	Cytokine receptor motif; other site
1195464010252	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1195464010253	Phage capsid family; Region: Phage_capsid; pfam05065
1195464010254	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1195464010255	oligomer interface [polypeptide binding]; other site
1195464010256	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1195464010257	active site residues [active]
1195464010258	Phage-related protein [Function unknown]; Region: COG4695
1195464010259	Phage portal protein; Region: Phage_portal; pfam04860
1195464010260	Phage Terminase; Region: Terminase_1; pfam03354
1195464010261	Phage terminase, small subunit; Region: Terminase_4; pfam05119
1195464010262	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1195464010263	active site
1195464010264	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1195464010265	Int/Topo IB signature motif; other site
1195464010266	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464010267	dUTPase; Region: dUTPase_2; pfam08761
1195464010268	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1195464010269	active site
1195464010270	homodimer interface [polypeptide binding]; other site
1195464010271	metal binding site [ion binding]; metal-binding site
1195464010272	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1195464010273	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
1195464010274	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1195464010275	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464010276	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1195464010277	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464010278	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1195464010279	non-specific DNA binding site [nucleotide binding]; other site
1195464010280	salt bridge; other site
1195464010281	sequence-specific DNA binding site [nucleotide binding]; other site
1195464010282	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464010283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464010284	non-specific DNA binding site [nucleotide binding]; other site
1195464010285	salt bridge; other site
1195464010286	sequence-specific DNA binding site [nucleotide binding]; other site
1195464010287	Glycogen synthesis protein; Region: GlgS; cl11663
1195464010288	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1195464010289	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1195464010290	Int/Topo IB signature motif; other site
1195464010291	hypothetical protein; Provisional; Region: PRK13670
1195464010292	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1195464010293	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1195464010294	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
1195464010295	protein binding site [polypeptide binding]; other site
1195464010296	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1195464010297	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1195464010298	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1195464010299	active site
1195464010300	nucleophile elbow; other site
1195464010301	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1195464010302	Nucleoside recognition; Region: Gate; pfam07670
1195464010303	Nucleoside recognition; Region: Gate; pfam07670
1195464010304	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1195464010305	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1195464010306	active site
1195464010307	(T/H)XGH motif; other site
1195464010308	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1195464010309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464010310	S-adenosylmethionine binding site [chemical binding]; other site
1195464010311	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
1195464010312	Protein of unknown function (DUF964); Region: DUF964; pfam06133
1195464010313	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464010314	catalytic core [active]
1195464010315	YlbE-like protein; Region: YlbE; pfam14003
1195464010316	Putative coat protein; Region: YlbD_coat; pfam14071
1195464010317	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1195464010318	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1195464010319	YugN-like family; Region: YugN; pfam08868
1195464010320	formamidase; Provisional; Region: amiF; PRK13287
1195464010321	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
1195464010322	multimer interface [polypeptide binding]; other site
1195464010323	active site
1195464010324	catalytic triad [active]
1195464010325	dimer interface [polypeptide binding]; other site
1195464010326	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
1195464010327	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
1195464010328	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1195464010329	Subunit I/III interface [polypeptide binding]; other site
1195464010330	Subunit III/IV interface [polypeptide binding]; other site
1195464010331	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1195464010332	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1195464010333	D-pathway; other site
1195464010334	Putative ubiquinol binding site [chemical binding]; other site
1195464010335	Low-spin heme (heme b) binding site [chemical binding]; other site
1195464010336	Putative water exit pathway; other site
1195464010337	Binuclear center (heme o3/CuB) [ion binding]; other site
1195464010338	K-pathway; other site
1195464010339	Putative proton exit pathway; other site
1195464010340	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1195464010341	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1195464010342	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1195464010343	Cytochrome c; Region: Cytochrom_C; pfam00034
1195464010344	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1195464010345	UbiA prenyltransferase family; Region: UbiA; pfam01040
1195464010346	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1195464010347	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1195464010348	pyruvate carboxylase; Reviewed; Region: PRK12999
1195464010349	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1195464010350	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1195464010351	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1195464010352	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1195464010353	active site
1195464010354	catalytic residues [active]
1195464010355	metal binding site [ion binding]; metal-binding site
1195464010356	homodimer binding site [polypeptide binding]; other site
1195464010357	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1195464010358	carboxyltransferase (CT) interaction site; other site
1195464010359	biotinylation site [posttranslational modification]; other site
1195464010360	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1195464010361	hypothetical protein; Provisional; Region: PRK13666
1195464010362	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1195464010363	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1195464010364	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1195464010365	putative active site [active]
1195464010366	PhoH-like protein; Region: PhoH; pfam02562
1195464010367	hypothetical protein; Provisional; Region: PRK06733
1195464010368	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
1195464010369	YlaH-like protein; Region: YlaH; pfam14036
1195464010370	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1195464010371	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1195464010372	G1 box; other site
1195464010373	putative GEF interaction site [polypeptide binding]; other site
1195464010374	GTP/Mg2+ binding site [chemical binding]; other site
1195464010375	Switch I region; other site
1195464010376	G2 box; other site
1195464010377	G3 box; other site
1195464010378	Switch II region; other site
1195464010379	G4 box; other site
1195464010380	G5 box; other site
1195464010381	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1195464010382	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1195464010383	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1195464010384	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1195464010385	active site
1195464010386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1195464010387	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1195464010388	hypothetical protein; Provisional; Region: PRK04387
1195464010389	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1195464010390	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1195464010391	homodimer interface [polypeptide binding]; other site
1195464010392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464010393	catalytic residue [active]
1195464010394	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1195464010395	transglutaminase; Provisional; Region: tgl; PRK03187
1195464010396	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
1195464010397	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
1195464010398	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
1195464010399	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1195464010400	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
1195464010401	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1195464010402	DHHW protein; Region: DHHW; pfam14286
1195464010403	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1195464010404	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464010405	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1195464010406	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1195464010407	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1195464010408	E3 interaction surface; other site
1195464010409	lipoyl attachment site [posttranslational modification]; other site
1195464010410	e3 binding domain; Region: E3_binding; pfam02817
1195464010411	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1195464010412	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1195464010413	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1195464010414	alpha subunit interface [polypeptide binding]; other site
1195464010415	TPP binding site [chemical binding]; other site
1195464010416	heterodimer interface [polypeptide binding]; other site
1195464010417	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464010418	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1195464010419	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1195464010420	TPP-binding site [chemical binding]; other site
1195464010421	heterodimer interface [polypeptide binding]; other site
1195464010422	tetramer interface [polypeptide binding]; other site
1195464010423	phosphorylation loop region [posttranslational modification]
1195464010424	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1195464010425	active site
1195464010426	catalytic residues [active]
1195464010427	metal binding site [ion binding]; metal-binding site
1195464010428	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464010429	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464010430	active site
1195464010431	motif I; other site
1195464010432	motif II; other site
1195464010433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464010434	hypothetical protein; Provisional; Region: PRK13667
1195464010435	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1195464010436	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464010437	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1195464010438	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1195464010439	TrkA-N domain; Region: TrkA_N; pfam02254
1195464010440	TrkA-C domain; Region: TrkA_C; pfam02080
1195464010441	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1195464010442	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464010443	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1195464010444	metal binding site [ion binding]; metal-binding site
1195464010445	putative dimer interface [polypeptide binding]; other site
1195464010446	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1195464010447	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1195464010448	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1195464010449	active site
1195464010450	trimer interface [polypeptide binding]; other site
1195464010451	substrate binding site [chemical binding]; other site
1195464010452	CoA binding site [chemical binding]; other site
1195464010453	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464010454	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464010455	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464010456	dimerization interface [polypeptide binding]; other site
1195464010457	FOG: CBS domain [General function prediction only]; Region: COG0517
1195464010458	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1195464010459	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
1195464010460	Protein of unknown function (DUF458); Region: DUF458; pfam04308
1195464010461	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
1195464010462	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1195464010463	catalytic residues [active]
1195464010464	Protein of unknown function (DUF3993); Region: DUF3993; pfam13158
1195464010465	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464010466	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
1195464010467	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1195464010468	short chain dehydrogenase; Provisional; Region: PRK07677
1195464010469	NAD(P) binding site [chemical binding]; other site
1195464010470	substrate binding site [chemical binding]; other site
1195464010471	homotetramer interface [polypeptide binding]; other site
1195464010472	active site
1195464010473	homodimer interface [polypeptide binding]; other site
1195464010474	phosphodiesterase YaeI; Provisional; Region: PRK11340
1195464010475	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1195464010476	putative active site [active]
1195464010477	putative metal binding site [ion binding]; other site
1195464010478	polyphosphate kinase; Provisional; Region: PRK05443
1195464010479	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1195464010480	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1195464010481	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1195464010482	putative domain interface [polypeptide binding]; other site
1195464010483	putative active site [active]
1195464010484	catalytic site [active]
1195464010485	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1195464010486	putative domain interface [polypeptide binding]; other site
1195464010487	putative active site [active]
1195464010488	catalytic site [active]
1195464010489	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1195464010490	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1195464010491	nucleotide binding site [chemical binding]; other site
1195464010492	YkyB-like protein; Region: YkyB; pfam14177
1195464010493	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
1195464010494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464010495	I-site; other site
1195464010496	active site
1195464010497	metal binding site [ion binding]; metal-binding site
1195464010498	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464010499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464010500	putative substrate translocation pore; other site
1195464010501	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464010502	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1195464010503	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1195464010504	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1195464010505	THF binding site; other site
1195464010506	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1195464010507	substrate binding site [chemical binding]; other site
1195464010508	THF binding site; other site
1195464010509	zinc-binding site [ion binding]; other site
1195464010510	Competence protein J (ComJ); Region: ComJ; pfam11033
1195464010511	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1195464010512	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1195464010513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464010514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464010515	dimer interface [polypeptide binding]; other site
1195464010516	phosphorylation site [posttranslational modification]
1195464010517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464010518	ATP binding site [chemical binding]; other site
1195464010519	Mg2+ binding site [ion binding]; other site
1195464010520	G-X-G motif; other site
1195464010521	aminotransferase A; Validated; Region: PRK07683
1195464010522	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464010523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464010524	homodimer interface [polypeptide binding]; other site
1195464010525	catalytic residue [active]
1195464010526	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464010527	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464010528	DNA binding site [nucleotide binding]
1195464010529	domain linker motif; other site
1195464010530	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1195464010531	putative dimerization interface [polypeptide binding]; other site
1195464010532	putative ligand binding site [chemical binding]; other site
1195464010533	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1195464010534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464010535	dimer interface [polypeptide binding]; other site
1195464010536	conserved gate region; other site
1195464010537	putative PBP binding loops; other site
1195464010538	ABC-ATPase subunit interface; other site
1195464010539	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1195464010540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464010541	dimer interface [polypeptide binding]; other site
1195464010542	conserved gate region; other site
1195464010543	putative PBP binding loops; other site
1195464010544	ABC-ATPase subunit interface; other site
1195464010545	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1195464010546	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1195464010547	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1195464010548	homodimer interface [polypeptide binding]; other site
1195464010549	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1195464010550	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1195464010551	active site
1195464010552	homodimer interface [polypeptide binding]; other site
1195464010553	catalytic site [active]
1195464010554	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1195464010555	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1195464010556	Ca binding site [ion binding]; other site
1195464010557	active site
1195464010558	catalytic site [active]
1195464010559	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1195464010560	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1195464010561	Walker A/P-loop; other site
1195464010562	ATP binding site [chemical binding]; other site
1195464010563	Q-loop/lid; other site
1195464010564	ABC transporter signature motif; other site
1195464010565	Walker B; other site
1195464010566	D-loop; other site
1195464010567	H-loop/switch region; other site
1195464010568	TOBE domain; Region: TOBE_2; pfam08402
1195464010569	hypothetical protein; Provisional; Region: PRK06720
1195464010570	NAD(P) binding site [chemical binding]; other site
1195464010571	RDD family; Region: RDD; pfam06271
1195464010572	Protein of unknown function (DUF3997); Region: DUF3997; pfam13162
1195464010573	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
1195464010574	Predicted ATPase [General function prediction only]; Region: COG3910
1195464010575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464010576	Walker A/P-loop; other site
1195464010577	ATP binding site [chemical binding]; other site
1195464010578	Q-loop/lid; other site
1195464010579	ABC transporter signature motif; other site
1195464010580	Walker B; other site
1195464010581	D-loop; other site
1195464010582	H-loop/switch region; other site
1195464010583	putative acyltransferase; Provisional; Region: PRK05790
1195464010584	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1195464010585	dimer interface [polypeptide binding]; other site
1195464010586	active site
1195464010587	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1195464010588	nudix motif; other site
1195464010589	Protein of unknown function (DUF3928); Region: DUF3928; pfam13065
1195464010590	hypothetical protein; Validated; Region: PRK07668
1195464010591	hypothetical protein; Validated; Region: PRK07668
1195464010592	hypothetical protein; Validated; Region: PRK07668
1195464010593	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464010594	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464010595	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1195464010596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464010597	NAD(P) binding site [chemical binding]; other site
1195464010598	active site
1195464010599	YvrJ protein family; Region: YvrJ; pfam12841
1195464010600	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1195464010601	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1195464010602	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1195464010603	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464010604	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1195464010605	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1195464010606	putative active site [active]
1195464010607	catalytic triad [active]
1195464010608	putative dimer interface [polypeptide binding]; other site
1195464010609	transaminase; Reviewed; Region: PRK08068
1195464010610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464010611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464010612	homodimer interface [polypeptide binding]; other site
1195464010613	catalytic residue [active]
1195464010614	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
1195464010615	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1195464010616	dimer interface [polypeptide binding]; other site
1195464010617	active site
1195464010618	catalytic residue [active]
1195464010619	metal binding site [ion binding]; metal-binding site
1195464010620	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552
1195464010621	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1195464010622	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
1195464010623	intersubunit interface [polypeptide binding]; other site
1195464010624	active site
1195464010625	Zn2+ binding site [ion binding]; other site
1195464010626	ARD/ARD' family; Region: ARD; pfam03079
1195464010627	Cupin domain; Region: Cupin_2; pfam07883
1195464010628	Protein of unknown function (DUF3909); Region: DUF3909; pfam13077
1195464010629	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1195464010630	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1195464010631	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464010632	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464010633	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464010634	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464010635	metal binding site [ion binding]; metal-binding site
1195464010636	active site
1195464010637	I-site; other site
1195464010638	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1195464010639	dimer interface [polypeptide binding]; other site
1195464010640	FMN binding site [chemical binding]; other site
1195464010641	Protein of unknown function (DUF3915); Region: DUF3915; pfam13054
1195464010642	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1195464010643	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1195464010644	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1195464010645	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1195464010646	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1195464010647	dimerization domain swap beta strand [polypeptide binding]; other site
1195464010648	regulatory protein interface [polypeptide binding]; other site
1195464010649	active site
1195464010650	regulatory phosphorylation site [posttranslational modification]; other site
1195464010651	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1195464010652	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1195464010653	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1195464010654	active site turn [active]
1195464010655	phosphorylation site [posttranslational modification]
1195464010656	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1195464010657	HPr interaction site; other site
1195464010658	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1195464010659	active site
1195464010660	phosphorylation site [posttranslational modification]
1195464010661	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1195464010662	CAT RNA binding domain; Region: CAT_RBD; smart01061
1195464010663	PRD domain; Region: PRD; pfam00874
1195464010664	PRD domain; Region: PRD; pfam00874
1195464010665	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464010666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464010667	active site
1195464010668	motif I; other site
1195464010669	motif II; other site
1195464010670	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464010671	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1195464010672	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464010673	DNA-binding site [nucleotide binding]; DNA binding site
1195464010674	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1195464010675	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1195464010676	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1195464010677	active site
1195464010678	trimer interface [polypeptide binding]; other site
1195464010679	allosteric site; other site
1195464010680	active site lid [active]
1195464010681	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1195464010682	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1195464010683	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1195464010684	active site
1195464010685	dimer interface [polypeptide binding]; other site
1195464010686	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1195464010687	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464010688	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1195464010689	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1195464010690	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1195464010691	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464010692	Coenzyme A binding pocket [chemical binding]; other site
1195464010693	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1195464010694	active site
1195464010695	Predicted secreted protein [Function unknown]; Region: COG4086
1195464010696	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1195464010697	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464010698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464010699	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464010700	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
1195464010701	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
1195464010702	stage V sporulation protein AD; Validated; Region: PRK08304
1195464010703	stage V sporulation protein AD; Provisional; Region: PRK12404
1195464010704	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1195464010705	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
1195464010706	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
1195464010707	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
1195464010708	Na2 binding site [ion binding]; other site
1195464010709	putative substrate binding site 1 [chemical binding]; other site
1195464010710	Na binding site 1 [ion binding]; other site
1195464010711	putative substrate binding site 2 [chemical binding]; other site
1195464010712	sporulation sigma factor SigF; Validated; Region: PRK05572
1195464010713	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464010714	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1195464010715	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464010716	DNA binding residues [nucleotide binding]
1195464010717	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1195464010718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464010719	ATP binding site [chemical binding]; other site
1195464010720	Mg2+ binding site [ion binding]; other site
1195464010721	G-X-G motif; other site
1195464010722	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
1195464010723	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464010724	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1195464010725	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1195464010726	Predicted transcriptional regulators [Transcription]; Region: COG1725
1195464010727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464010728	DNA-binding site [nucleotide binding]; DNA binding site
1195464010729	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464010730	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464010731	Walker A/P-loop; other site
1195464010732	ATP binding site [chemical binding]; other site
1195464010733	Q-loop/lid; other site
1195464010734	ABC transporter signature motif; other site
1195464010735	Walker B; other site
1195464010736	D-loop; other site
1195464010737	H-loop/switch region; other site
1195464010738	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464010739	MarR family; Region: MarR; pfam01047
1195464010740	MarR family; Region: MarR_2; cl17246
1195464010741	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1195464010742	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1195464010743	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1195464010744	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1195464010745	oligomer interface [polypeptide binding]; other site
1195464010746	metal binding site [ion binding]; metal-binding site
1195464010747	metal binding site [ion binding]; metal-binding site
1195464010748	putative Cl binding site [ion binding]; other site
1195464010749	aspartate ring; other site
1195464010750	basic sphincter; other site
1195464010751	hydrophobic gate; other site
1195464010752	periplasmic entrance; other site
1195464010753	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1195464010754	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1195464010755	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1195464010756	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1195464010757	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1195464010758	phosphopentomutase; Provisional; Region: PRK05362
1195464010759	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1195464010760	YtkA-like; Region: YtkA; pfam13115
1195464010761	YtkA-like; Region: YtkA; pfam13115
1195464010762	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1195464010763	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1195464010764	active site
1195464010765	Int/Topo IB signature motif; other site
1195464010766	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
1195464010767	ferric uptake regulator; Provisional; Region: fur; PRK09462
1195464010768	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1195464010769	metal binding site 2 [ion binding]; metal-binding site
1195464010770	putative DNA binding helix; other site
1195464010771	metal binding site 1 [ion binding]; metal-binding site
1195464010772	dimer interface [polypeptide binding]; other site
1195464010773	structural Zn2+ binding site [ion binding]; other site
1195464010774	stage II sporulation protein M; Region: spo_II_M; TIGR02831
1195464010775	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464010776	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464010777	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1195464010778	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1195464010779	dimer interface [polypeptide binding]; other site
1195464010780	ADP-ribose binding site [chemical binding]; other site
1195464010781	active site
1195464010782	nudix motif; other site
1195464010783	metal binding site [ion binding]; metal-binding site
1195464010784	Protein of unknown function (DUF3936); Region: DUF3936; pfam13072
1195464010785	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464010786	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464010787	active site
1195464010788	catalytic tetrad [active]
1195464010789	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464010790	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464010791	active site
1195464010792	catalytic tetrad [active]
1195464010793	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1195464010794	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
1195464010795	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1195464010796	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1195464010797	putative active site [active]
1195464010798	putative metal binding site [ion binding]; other site
1195464010799	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1195464010800	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
1195464010801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464010802	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464010803	Predicted permease [General function prediction only]; Region: COG2056
1195464010804	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1195464010805	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1195464010806	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464010807	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464010808	DNA binding site [nucleotide binding]
1195464010809	domain linker motif; other site
1195464010810	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1195464010811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464010812	Coenzyme A binding pocket [chemical binding]; other site
1195464010813	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464010814	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
1195464010815	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
1195464010816	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1195464010817	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1195464010818	catalytic motif [active]
1195464010819	Zn binding site [ion binding]; other site
1195464010820	RibD C-terminal domain; Region: RibD_C; cl17279
1195464010821	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1195464010822	Lumazine binding domain; Region: Lum_binding; pfam00677
1195464010823	Lumazine binding domain; Region: Lum_binding; pfam00677
1195464010824	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1195464010825	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1195464010826	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1195464010827	dimerization interface [polypeptide binding]; other site
1195464010828	active site
1195464010829	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1195464010830	homopentamer interface [polypeptide binding]; other site
1195464010831	active site
1195464010832	biotin synthase; Validated; Region: PRK06256
1195464010833	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464010834	FeS/SAM binding site; other site
1195464010835	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1195464010836	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1195464010837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464010838	S-adenosylmethionine binding site [chemical binding]; other site
1195464010839	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1195464010840	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1195464010841	nucleophilic elbow; other site
1195464010842	catalytic triad; other site
1195464010843	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1195464010844	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1195464010845	substrate-cofactor binding pocket; other site
1195464010846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464010847	catalytic residue [active]
1195464010848	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1195464010849	AAA domain; Region: AAA_26; pfam13500
1195464010850	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
1195464010851	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464010852	inhibitor-cofactor binding pocket; inhibition site
1195464010853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464010854	catalytic residue [active]
1195464010855	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1195464010856	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1195464010857	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1195464010858	active site
1195464010859	metal binding site [ion binding]; metal-binding site
1195464010860	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1195464010861	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1195464010862	active site
1195464010863	catalytic triad [active]
1195464010864	oxyanion hole [active]
1195464010865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464010866	dimerization interface [polypeptide binding]; other site
1195464010867	putative DNA binding site [nucleotide binding]; other site
1195464010868	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464010869	putative Zn2+ binding site [ion binding]; other site
1195464010870	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
1195464010871	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1195464010872	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1195464010873	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1195464010874	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
1195464010875	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464010876	inhibitor-cofactor binding pocket; inhibition site
1195464010877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464010878	catalytic residue [active]
1195464010879	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1195464010880	nucleotide binding site [chemical binding]; other site
1195464010881	N-acetyl-L-glutamate binding site [chemical binding]; other site
1195464010882	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1195464010883	heterotetramer interface [polypeptide binding]; other site
1195464010884	active site pocket [active]
1195464010885	cleavage site
1195464010886	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1195464010887	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1195464010888	YqzH-like protein; Region: YqzH; pfam14164
1195464010889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464010890	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1195464010891	NAD(P) binding site [chemical binding]; other site
1195464010892	active site
1195464010893	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464010894	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679
1195464010895	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1195464010896	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1195464010897	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1195464010898	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1195464010899	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1195464010900	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1195464010901	putative L-serine binding site [chemical binding]; other site
1195464010902	ribonuclease Z; Region: RNase_Z; TIGR02651
1195464010903	Protein of unknown function (DUF3932); Region: DUF3932; pfam13068
1195464010904	magnesium-transporting ATPase; Provisional; Region: PRK15122
1195464010905	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1195464010906	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464010907	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1195464010908	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1195464010909	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1195464010910	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1195464010911	MgtC family; Region: MgtC; pfam02308
1195464010912	DNA polymerase IV; Validated; Region: PRK01810
1195464010913	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1195464010914	active site
1195464010915	DNA binding site [nucleotide binding]
1195464010916	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1195464010917	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1195464010918	peptidase T-like protein; Region: PepT-like; TIGR01883
1195464010919	metal binding site [ion binding]; metal-binding site
1195464010920	putative dimer interface [polypeptide binding]; other site
1195464010921	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464010922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464010923	Protein of unknown function (DUF3894); Region: DUF3894; pfam13033
1195464010924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1195464010925	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1195464010926	Predicted membrane protein [Function unknown]; Region: COG4129
1195464010927	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1195464010928	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1195464010929	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1195464010930	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1195464010931	Walker A/P-loop; other site
1195464010932	ATP binding site [chemical binding]; other site
1195464010933	Q-loop/lid; other site
1195464010934	ABC transporter signature motif; other site
1195464010935	Walker B; other site
1195464010936	D-loop; other site
1195464010937	H-loop/switch region; other site
1195464010938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464010939	dimer interface [polypeptide binding]; other site
1195464010940	conserved gate region; other site
1195464010941	putative PBP binding loops; other site
1195464010942	ABC-ATPase subunit interface; other site
1195464010943	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1195464010944	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464010945	substrate binding pocket [chemical binding]; other site
1195464010946	membrane-bound complex binding site; other site
1195464010947	hinge residues; other site
1195464010948	Disulphide isomerase; Region: Disulph_isomer; pfam06491
1195464010949	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1195464010950	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1195464010951	nudix motif; other site
1195464010952	Predicted membrane protein [Function unknown]; Region: COG2323
1195464010953	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1195464010954	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1195464010955	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1195464010956	E3 interaction surface; other site
1195464010957	lipoyl attachment site [posttranslational modification]; other site
1195464010958	e3 binding domain; Region: E3_binding; pfam02817
1195464010959	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1195464010960	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1195464010961	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1195464010962	alpha subunit interface [polypeptide binding]; other site
1195464010963	TPP binding site [chemical binding]; other site
1195464010964	heterodimer interface [polypeptide binding]; other site
1195464010965	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464010966	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1195464010967	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1195464010968	tetramer interface [polypeptide binding]; other site
1195464010969	TPP-binding site [chemical binding]; other site
1195464010970	heterodimer interface [polypeptide binding]; other site
1195464010971	phosphorylation loop region [posttranslational modification]
1195464010972	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1195464010973	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1195464010974	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464010975	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1195464010976	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1195464010977	nucleotide binding site [chemical binding]; other site
1195464010978	Acetokinase family; Region: Acetate_kinase; cl17229
1195464010979	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1195464010980	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1195464010981	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1195464010982	NAD binding site [chemical binding]; other site
1195464010983	Phe binding site; other site
1195464010984	phosphate butyryltransferase; Validated; Region: PRK07742
1195464010985	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1195464010986	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1195464010987	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464010988	putative active site [active]
1195464010989	heme pocket [chemical binding]; other site
1195464010990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464010991	putative active site [active]
1195464010992	heme pocket [chemical binding]; other site
1195464010993	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464010994	Walker A motif; other site
1195464010995	ATP binding site [chemical binding]; other site
1195464010996	Walker B motif; other site
1195464010997	arginine finger; other site
1195464010998	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1195464010999	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
1195464011000	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1195464011001	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1195464011002	active site
1195464011003	catalytic site [active]
1195464011004	metal binding site [ion binding]; metal-binding site
1195464011005	dimer interface [polypeptide binding]; other site
1195464011006	YycC-like protein; Region: YycC; pfam14174
1195464011007	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1195464011008	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1195464011009	DXD motif; other site
1195464011010	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1195464011011	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1195464011012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464011013	active site
1195464011014	phosphorylation site [posttranslational modification]
1195464011015	intermolecular recognition site; other site
1195464011016	dimerization interface [polypeptide binding]; other site
1195464011017	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1195464011018	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1195464011019	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1195464011020	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1195464011021	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1195464011022	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1195464011023	Walker A/P-loop; other site
1195464011024	ATP binding site [chemical binding]; other site
1195464011025	Q-loop/lid; other site
1195464011026	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1195464011027	ABC transporter signature motif; other site
1195464011028	Walker B; other site
1195464011029	D-loop; other site
1195464011030	H-loop/switch region; other site
1195464011031	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1195464011032	arginine repressor; Provisional; Region: PRK04280
1195464011033	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1195464011034	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1195464011035	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464011036	RNA binding surface [nucleotide binding]; other site
1195464011037	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1195464011038	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1195464011039	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1195464011040	TPP-binding site; other site
1195464011041	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1195464011042	PYR/PP interface [polypeptide binding]; other site
1195464011043	dimer interface [polypeptide binding]; other site
1195464011044	TPP binding site [chemical binding]; other site
1195464011045	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1195464011046	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1195464011047	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1195464011048	substrate binding pocket [chemical binding]; other site
1195464011049	chain length determination region; other site
1195464011050	substrate-Mg2+ binding site; other site
1195464011051	catalytic residues [active]
1195464011052	aspartate-rich region 1; other site
1195464011053	active site lid residues [active]
1195464011054	aspartate-rich region 2; other site
1195464011055	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
1195464011056	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1195464011057	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1195464011058	generic binding surface II; other site
1195464011059	generic binding surface I; other site
1195464011060	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1195464011061	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1195464011062	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1195464011063	homodimer interface [polypeptide binding]; other site
1195464011064	NADP binding site [chemical binding]; other site
1195464011065	substrate binding site [chemical binding]; other site
1195464011066	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1195464011067	Asp23 family; Region: Asp23; pfam03780
1195464011068	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1195464011069	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1195464011070	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1195464011071	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1195464011072	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1195464011073	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1195464011074	carboxyltransferase (CT) interaction site; other site
1195464011075	biotinylation site [posttranslational modification]; other site
1195464011076	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1195464011077	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1195464011078	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
1195464011079	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
1195464011080	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
1195464011081	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
1195464011082	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
1195464011083	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
1195464011084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464011085	Walker A motif; other site
1195464011086	ATP binding site [chemical binding]; other site
1195464011087	Walker B motif; other site
1195464011088	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
1195464011089	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464011090	elongation factor P; Validated; Region: PRK00529
1195464011091	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1195464011092	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1195464011093	RNA binding site [nucleotide binding]; other site
1195464011094	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1195464011095	RNA binding site [nucleotide binding]; other site
1195464011096	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1195464011097	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1195464011098	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1195464011099	active site
1195464011100	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1195464011101	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1195464011102	trimer interface [polypeptide binding]; other site
1195464011103	active site
1195464011104	dimer interface [polypeptide binding]; other site
1195464011105	Conserved membrane protein YqhR; Region: YqhR; pfam11085
1195464011106	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
1195464011107	Carbon starvation protein CstA; Region: CstA; pfam02554
1195464011108	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1195464011109	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1195464011110	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464011111	motif II; other site
1195464011112	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1195464011113	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1195464011114	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1195464011115	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1195464011116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464011117	FeS/SAM binding site; other site
1195464011118	Predicted transcriptional regulators [Transcription]; Region: COG1695
1195464011119	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1195464011120	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1195464011121	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464011122	active site residue [active]
1195464011123	coronin; Provisional; Region: PTZ00420
1195464011124	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464011125	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464011126	DNA binding site [nucleotide binding]
1195464011127	domain linker motif; other site
1195464011128	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1195464011129	putative dimerization interface [polypeptide binding]; other site
1195464011130	putative ligand binding site [chemical binding]; other site
1195464011131	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464011132	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464011133	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1195464011134	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1195464011135	Protein of unknown function (DUF3975); Region: DUF3975; pfam13126
1195464011136	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1195464011137	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1195464011138	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1195464011139	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464011140	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464011141	Walker A/P-loop; other site
1195464011142	ATP binding site [chemical binding]; other site
1195464011143	Q-loop/lid; other site
1195464011144	ABC transporter signature motif; other site
1195464011145	Walker B; other site
1195464011146	D-loop; other site
1195464011147	H-loop/switch region; other site
1195464011148	Predicted transcriptional regulators [Transcription]; Region: COG1725
1195464011149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464011150	DNA-binding site [nucleotide binding]; DNA binding site
1195464011151	Protein of unknown function (DUF3929); Region: DUF3929; pfam13066
1195464011152	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1195464011153	tetramer interface [polypeptide binding]; other site
1195464011154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011155	catalytic residue [active]
1195464011156	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1195464011157	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1195464011158	tetramer interface [polypeptide binding]; other site
1195464011159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011160	catalytic residue [active]
1195464011161	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1195464011162	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1195464011163	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1195464011164	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1195464011165	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464011166	ATP binding site [chemical binding]; other site
1195464011167	putative Mg++ binding site [ion binding]; other site
1195464011168	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464011169	nucleotide binding region [chemical binding]; other site
1195464011170	ATP-binding site [chemical binding]; other site
1195464011171	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
1195464011172	YqzE-like protein; Region: YqzE; pfam14038
1195464011173	Shikimate kinase; Region: SKI; pfam01202
1195464011174	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1195464011175	ADP binding site [chemical binding]; other site
1195464011176	magnesium binding site [ion binding]; other site
1195464011177	putative shikimate binding site; other site
1195464011178	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1195464011179	ComG operon protein 7; Region: ComGG; pfam14173
1195464011180	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1195464011181	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1195464011182	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1195464011183	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1195464011184	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1195464011185	Type II/IV secretion system protein; Region: T2SE; pfam00437
1195464011186	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1195464011187	Walker A motif; other site
1195464011188	ATP binding site [chemical binding]; other site
1195464011189	Walker B motif; other site
1195464011190	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464011191	putative DNA binding site [nucleotide binding]; other site
1195464011192	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
1195464011193	putative Zn2+ binding site [ion binding]; other site
1195464011194	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
1195464011195	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1195464011196	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1195464011197	Protein of unknown function (DUF3912); Region: DUF3912; pfam13051
1195464011198	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
1195464011199	Protein of unknown function (DUF3966); Region: DUF3966; pfam13110
1195464011200	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1195464011201	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1195464011202	active site
1195464011203	homodimer interface [polypeptide binding]; other site
1195464011204	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1195464011205	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1195464011206	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1195464011207	substrate binding pocket [chemical binding]; other site
1195464011208	dimer interface [polypeptide binding]; other site
1195464011209	inhibitor binding site; inhibition site
1195464011210	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1195464011211	B12 binding site [chemical binding]; other site
1195464011212	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1195464011213	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1195464011214	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1195464011215	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1195464011216	FAD binding site [chemical binding]; other site
1195464011217	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1195464011218	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1195464011219	homodimer interface [polypeptide binding]; other site
1195464011220	substrate-cofactor binding pocket; other site
1195464011221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011222	catalytic residue [active]
1195464011223	cystathionine beta-lyase; Provisional; Region: PRK08064
1195464011224	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1195464011225	homodimer interface [polypeptide binding]; other site
1195464011226	substrate-cofactor binding pocket; other site
1195464011227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011228	catalytic residue [active]
1195464011229	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464011230	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1195464011231	catalytic triad [active]
1195464011232	conserved cis-peptide bond; other site
1195464011233	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464011234	dimerization interface [polypeptide binding]; other site
1195464011235	putative DNA binding site [nucleotide binding]; other site
1195464011236	putative Zn2+ binding site [ion binding]; other site
1195464011237	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
1195464011238	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1195464011239	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
1195464011240	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1195464011241	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1195464011242	nucleotide binding site [chemical binding]; other site
1195464011243	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1195464011244	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1195464011245	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1195464011246	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1195464011247	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1195464011248	active site
1195464011249	Substrate binding site; other site
1195464011250	Mg++ binding site; other site
1195464011251	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1195464011252	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1195464011253	active site
1195464011254	metal binding site [ion binding]; metal-binding site
1195464011255	substrate binding site [chemical binding]; other site
1195464011256	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1195464011257	PhoU domain; Region: PhoU; pfam01895
1195464011258	PhoU domain; Region: PhoU; pfam01895
1195464011259	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
1195464011260	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1195464011261	Walker A/P-loop; other site
1195464011262	ATP binding site [chemical binding]; other site
1195464011263	Q-loop/lid; other site
1195464011264	ABC transporter signature motif; other site
1195464011265	Walker B; other site
1195464011266	D-loop; other site
1195464011267	H-loop/switch region; other site
1195464011268	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1195464011269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464011270	dimer interface [polypeptide binding]; other site
1195464011271	conserved gate region; other site
1195464011272	putative PBP binding loops; other site
1195464011273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1195464011274	ABC-ATPase subunit interface; other site
1195464011275	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1195464011276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464011277	dimer interface [polypeptide binding]; other site
1195464011278	conserved gate region; other site
1195464011279	putative PBP binding loops; other site
1195464011280	ABC-ATPase subunit interface; other site
1195464011281	PBP superfamily domain; Region: PBP_like_2; cl17296
1195464011282	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464011283	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464011284	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464011285	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464011286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464011287	putative substrate translocation pore; other site
1195464011288	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464011289	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1195464011290	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1195464011291	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1195464011292	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
1195464011293	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1195464011294	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1195464011295	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1195464011296	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1195464011297	metal binding site 2 [ion binding]; metal-binding site
1195464011298	putative DNA binding helix; other site
1195464011299	metal binding site 1 [ion binding]; metal-binding site
1195464011300	dimer interface [polypeptide binding]; other site
1195464011301	structural Zn2+ binding site [ion binding]; other site
1195464011302	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1195464011303	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464011304	ABC-ATPase subunit  interface; other site
1195464011305	dimer interface [polypeptide binding]; other site
1195464011306	putative PBP binding regions; other site
1195464011307	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1195464011308	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1195464011309	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464011310	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464011311	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464011312	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464011313	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
1195464011314	endonuclease IV; Provisional; Region: PRK01060
1195464011315	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1195464011316	AP (apurinic/apyrimidinic) site pocket; other site
1195464011317	DNA interaction; other site
1195464011318	Metal-binding active site; metal-binding site
1195464011319	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1195464011320	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1195464011321	ATP binding site [chemical binding]; other site
1195464011322	Mg++ binding site [ion binding]; other site
1195464011323	motif III; other site
1195464011324	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464011325	nucleotide binding region [chemical binding]; other site
1195464011326	ATP-binding site [chemical binding]; other site
1195464011327	YqfQ-like protein; Region: YqfQ; pfam14181
1195464011328	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1195464011329	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1195464011330	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1195464011331	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1195464011332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1195464011333	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1195464011334	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1195464011335	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1195464011336	Family of unknown function (DUF633); Region: DUF633; pfam04816
1195464011337	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1195464011338	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1195464011339	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1195464011340	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1195464011341	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1195464011342	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464011343	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1195464011344	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464011345	DNA binding residues [nucleotide binding]
1195464011346	DNA primase; Validated; Region: dnaG; PRK05667
1195464011347	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1195464011348	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1195464011349	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1195464011350	active site
1195464011351	metal binding site [ion binding]; metal-binding site
1195464011352	interdomain interaction site; other site
1195464011353	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1195464011354	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1195464011355	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
1195464011356	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1195464011357	HTH domain; Region: HTH_11; pfam08279
1195464011358	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1195464011359	FOG: CBS domain [General function prediction only]; Region: COG0517
1195464011360	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1195464011361	Recombination protein O N terminal; Region: RecO_N; pfam11967
1195464011362	Recombination protein O C terminal; Region: RecO_C; pfam02565
1195464011363	YqzL-like protein; Region: YqzL; pfam14006
1195464011364	GTPase Era; Reviewed; Region: era; PRK00089
1195464011365	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1195464011366	G1 box; other site
1195464011367	GTP/Mg2+ binding site [chemical binding]; other site
1195464011368	Switch I region; other site
1195464011369	G2 box; other site
1195464011370	Switch II region; other site
1195464011371	G3 box; other site
1195464011372	G4 box; other site
1195464011373	G5 box; other site
1195464011374	KH domain; Region: KH_2; pfam07650
1195464011375	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1195464011376	active site
1195464011377	catalytic motif [active]
1195464011378	Zn binding site [ion binding]; other site
1195464011379	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1195464011380	metal-binding heat shock protein; Provisional; Region: PRK00016
1195464011381	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1195464011382	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1195464011383	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464011384	Zn2+ binding site [ion binding]; other site
1195464011385	Mg2+ binding site [ion binding]; other site
1195464011386	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1195464011387	PhoH-like protein; Region: PhoH; pfam02562
1195464011388	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
1195464011389	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1195464011390	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
1195464011391	Yqey-like protein; Region: YqeY; pfam09424
1195464011392	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1195464011393	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1195464011394	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1195464011395	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464011396	FeS/SAM binding site; other site
1195464011397	TRAM domain; Region: TRAM; cl01282
1195464011398	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1195464011399	RNA methyltransferase, RsmE family; Region: TIGR00046
1195464011400	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1195464011401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464011402	S-adenosylmethionine binding site [chemical binding]; other site
1195464011403	chaperone protein DnaJ; Provisional; Region: PRK14280
1195464011404	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1195464011405	HSP70 interaction site [polypeptide binding]; other site
1195464011406	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1195464011407	substrate binding site [polypeptide binding]; other site
1195464011408	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1195464011409	Zn binding sites [ion binding]; other site
1195464011410	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1195464011411	dimer interface [polypeptide binding]; other site
1195464011412	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1195464011413	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1195464011414	nucleotide binding site [chemical binding]; other site
1195464011415	NEF interaction site [polypeptide binding]; other site
1195464011416	SBD interface [polypeptide binding]; other site
1195464011417	GrpE; Region: GrpE; pfam01025
1195464011418	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1195464011419	dimer interface [polypeptide binding]; other site
1195464011420	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1195464011421	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1195464011422	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1195464011423	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1195464011424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464011425	FeS/SAM binding site; other site
1195464011426	HemN C-terminal domain; Region: HemN_C; pfam06969
1195464011427	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464011428	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1195464011429	GTP-binding protein LepA; Provisional; Region: PRK05433
1195464011430	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1195464011431	G1 box; other site
1195464011432	putative GEF interaction site [polypeptide binding]; other site
1195464011433	GTP/Mg2+ binding site [chemical binding]; other site
1195464011434	Switch I region; other site
1195464011435	G2 box; other site
1195464011436	G3 box; other site
1195464011437	Switch II region; other site
1195464011438	G4 box; other site
1195464011439	G5 box; other site
1195464011440	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1195464011441	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1195464011442	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1195464011443	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
1195464011444	germination protease; Provisional; Region: PRK02858
1195464011445	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1195464011446	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1195464011447	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1195464011448	YqzM-like protein; Region: YqzM; pfam14141
1195464011449	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1195464011450	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1195464011451	Competence protein; Region: Competence; pfam03772
1195464011452	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464011453	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1195464011454	catalytic motif [active]
1195464011455	Zn binding site [ion binding]; other site
1195464011456	SLBB domain; Region: SLBB; pfam10531
1195464011457	comEA protein; Region: comE; TIGR01259
1195464011458	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1195464011459	late competence protein ComER; Validated; Region: PRK07680
1195464011460	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1195464011461	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1195464011462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464011463	S-adenosylmethionine binding site [chemical binding]; other site
1195464011464	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
1195464011465	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1195464011466	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464011467	Zn2+ binding site [ion binding]; other site
1195464011468	Mg2+ binding site [ion binding]; other site
1195464011469	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1195464011470	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1195464011471	active site
1195464011472	(T/H)XGH motif; other site
1195464011473	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1195464011474	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1195464011475	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1195464011476	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1195464011477	shikimate binding site; other site
1195464011478	NAD(P) binding site [chemical binding]; other site
1195464011479	GTPase YqeH; Provisional; Region: PRK13796
1195464011480	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1195464011481	GTP/Mg2+ binding site [chemical binding]; other site
1195464011482	G4 box; other site
1195464011483	G5 box; other site
1195464011484	G1 box; other site
1195464011485	Switch I region; other site
1195464011486	G2 box; other site
1195464011487	G3 box; other site
1195464011488	Switch II region; other site
1195464011489	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1195464011490	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464011491	active site
1195464011492	motif I; other site
1195464011493	motif II; other site
1195464011494	Sporulation inhibitor A; Region: Sda; pfam08970
1195464011495	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
1195464011496	sporulation sigma factor SigK; Reviewed; Region: PRK05803
1195464011497	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464011498	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464011499	DNA binding residues [nucleotide binding]
1195464011500	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1195464011501	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1195464011502	dimer interface [polypeptide binding]; other site
1195464011503	FMN binding site [chemical binding]; other site
1195464011504	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1195464011505	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1195464011506	synthetase active site [active]
1195464011507	NTP binding site [chemical binding]; other site
1195464011508	metal binding site [ion binding]; metal-binding site
1195464011509	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1195464011510	dimer interface [polypeptide binding]; other site
1195464011511	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1195464011512	active site
1195464011513	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464011514	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464011515	Coenzyme A binding pocket [chemical binding]; other site
1195464011516	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1195464011517	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464011518	DoxX; Region: DoxX; cl17842
1195464011519	CHAT domain; Region: CHAT; cl17868
1195464011520	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1195464011521	catalytic core [active]
1195464011522	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1195464011523	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1195464011524	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1195464011525	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1195464011526	putative active site [active]
1195464011527	catalytic triad [active]
1195464011528	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1195464011529	putative integrin binding motif; other site
1195464011530	PA/protease domain interface [polypeptide binding]; other site
1195464011531	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1195464011532	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1195464011533	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
1195464011534	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
1195464011535	cofactor binding site; other site
1195464011536	metal binding site [ion binding]; metal-binding site
1195464011537	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1195464011538	aromatic arch; other site
1195464011539	DCoH dimer interaction site [polypeptide binding]; other site
1195464011540	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1195464011541	DCoH tetramer interaction site [polypeptide binding]; other site
1195464011542	substrate binding site [chemical binding]; other site
1195464011543	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1195464011544	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1195464011545	putative metal binding site [ion binding]; other site
1195464011546	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1195464011547	active site
1195464011548	Predicted membrane protein [Function unknown]; Region: COG2259
1195464011549	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1195464011550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464011551	non-specific DNA binding site [nucleotide binding]; other site
1195464011552	salt bridge; other site
1195464011553	sequence-specific DNA binding site [nucleotide binding]; other site
1195464011554	Cupin domain; Region: Cupin_2; pfam07883
1195464011555	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1195464011556	active site 2 [active]
1195464011557	active site 1 [active]
1195464011558	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464011559	Coenzyme A binding pocket [chemical binding]; other site
1195464011560	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464011561	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464011562	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1195464011563	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1195464011564	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1195464011565	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1195464011566	Walker A/P-loop; other site
1195464011567	ATP binding site [chemical binding]; other site
1195464011568	Q-loop/lid; other site
1195464011569	ABC transporter signature motif; other site
1195464011570	Walker B; other site
1195464011571	D-loop; other site
1195464011572	H-loop/switch region; other site
1195464011573	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1195464011574	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464011575	ABC-ATPase subunit  interface; other site
1195464011576	dimer interface [polypeptide binding]; other site
1195464011577	putative PBP binding regions; other site
1195464011578	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464011579	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1195464011580	intersubunit interface [polypeptide binding]; other site
1195464011581	YrhC-like protein; Region: YrhC; pfam14143
1195464011582	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1195464011583	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1195464011584	putative catalytic cysteine [active]
1195464011585	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1195464011586	putative active site [active]
1195464011587	metal binding site [ion binding]; metal-binding site
1195464011588	cystathionine beta-lyase; Provisional; Region: PRK07671
1195464011589	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1195464011590	homodimer interface [polypeptide binding]; other site
1195464011591	substrate-cofactor binding pocket; other site
1195464011592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011593	catalytic residue [active]
1195464011594	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1195464011595	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1195464011596	dimer interface [polypeptide binding]; other site
1195464011597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011598	catalytic residue [active]
1195464011599	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1195464011600	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1195464011601	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1195464011602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464011603	S-adenosylmethionine binding site [chemical binding]; other site
1195464011604	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
1195464011605	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
1195464011606	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1195464011607	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1195464011608	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464011609	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1195464011610	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1195464011611	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1195464011612	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1195464011613	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1195464011614	ATP-binding site [chemical binding]; other site
1195464011615	Sugar specificity; other site
1195464011616	Pyrimidine base specificity; other site
1195464011617	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1195464011618	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1195464011619	Peptidase family U32; Region: Peptidase_U32; pfam01136
1195464011620	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1195464011621	Protein of unknown function (DUF556); Region: DUF556; cl00822
1195464011622	Peptidase family U32; Region: Peptidase_U32; pfam01136
1195464011623	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1195464011624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464011625	S-adenosylmethionine binding site [chemical binding]; other site
1195464011626	YceG-like family; Region: YceG; pfam02618
1195464011627	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1195464011628	dimerization interface [polypeptide binding]; other site
1195464011629	hypothetical protein; Provisional; Region: PRK13678
1195464011630	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1195464011631	hypothetical protein; Provisional; Region: PRK05473
1195464011632	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1195464011633	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1195464011634	motif 1; other site
1195464011635	active site
1195464011636	motif 2; other site
1195464011637	motif 3; other site
1195464011638	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1195464011639	DHHA1 domain; Region: DHHA1; pfam02272
1195464011640	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1195464011641	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1195464011642	Protein of unknown function (DUF3918); Region: DUF3918; pfam13056
1195464011643	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1195464011644	AAA domain; Region: AAA_30; pfam13604
1195464011645	Family description; Region: UvrD_C_2; pfam13538
1195464011646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464011647	TPR motif; other site
1195464011648	TPR repeat; Region: TPR_11; pfam13414
1195464011649	binding surface
1195464011650	TPR repeat; Region: TPR_11; pfam13414
1195464011651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464011652	binding surface
1195464011653	TPR motif; other site
1195464011654	TPR repeat; Region: TPR_11; pfam13414
1195464011655	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1195464011656	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1195464011657	Ligand Binding Site [chemical binding]; other site
1195464011658	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1195464011659	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1195464011660	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464011661	catalytic residue [active]
1195464011662	Predicted transcriptional regulator [Transcription]; Region: COG1959
1195464011663	Transcriptional regulator; Region: Rrf2; pfam02082
1195464011664	recombination factor protein RarA; Reviewed; Region: PRK13342
1195464011665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464011666	Walker A motif; other site
1195464011667	ATP binding site [chemical binding]; other site
1195464011668	Walker B motif; other site
1195464011669	arginine finger; other site
1195464011670	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1195464011671	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1195464011672	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1195464011673	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1195464011674	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1195464011675	putative ATP binding site [chemical binding]; other site
1195464011676	putative substrate interface [chemical binding]; other site
1195464011677	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1195464011678	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1195464011679	dimer interface [polypeptide binding]; other site
1195464011680	anticodon binding site; other site
1195464011681	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1195464011682	homodimer interface [polypeptide binding]; other site
1195464011683	motif 1; other site
1195464011684	active site
1195464011685	motif 2; other site
1195464011686	GAD domain; Region: GAD; pfam02938
1195464011687	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1195464011688	motif 3; other site
1195464011689	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1195464011690	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1195464011691	dimer interface [polypeptide binding]; other site
1195464011692	motif 1; other site
1195464011693	active site
1195464011694	motif 2; other site
1195464011695	motif 3; other site
1195464011696	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1195464011697	anticodon binding site; other site
1195464011698	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1195464011699	putative active site [active]
1195464011700	dimerization interface [polypeptide binding]; other site
1195464011701	putative tRNAtyr binding site [nucleotide binding]; other site
1195464011702	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1195464011703	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464011704	Zn2+ binding site [ion binding]; other site
1195464011705	Mg2+ binding site [ion binding]; other site
1195464011706	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1195464011707	synthetase active site [active]
1195464011708	NTP binding site [chemical binding]; other site
1195464011709	metal binding site [ion binding]; metal-binding site
1195464011710	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1195464011711	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1195464011712	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464011713	active site
1195464011714	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1195464011715	DHH family; Region: DHH; pfam01368
1195464011716	DHHA1 domain; Region: DHHA1; pfam02272
1195464011717	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
1195464011718	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1195464011719	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1195464011720	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
1195464011721	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1195464011722	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1195464011723	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1195464011724	Protein export membrane protein; Region: SecD_SecF; pfam02355
1195464011725	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1195464011726	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1195464011727	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1195464011728	Predicted membrane protein [Function unknown]; Region: COG2323
1195464011729	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
1195464011730	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1195464011731	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1195464011732	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1195464011733	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1195464011734	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1195464011735	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1195464011736	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1195464011737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464011738	Walker A motif; other site
1195464011739	ATP binding site [chemical binding]; other site
1195464011740	Walker B motif; other site
1195464011741	arginine finger; other site
1195464011742	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1195464011743	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1195464011744	RuvA N terminal domain; Region: RuvA_N; pfam01330
1195464011745	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1195464011746	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464011747	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1195464011748	putative ligand binding residues [chemical binding]; other site
1195464011749	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
1195464011750	BofC C-terminal domain; Region: BofC_C; pfam08955
1195464011751	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1195464011752	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464011753	quinolinate synthetase; Provisional; Region: PRK09375
1195464011754	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
1195464011755	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1195464011756	dimerization interface [polypeptide binding]; other site
1195464011757	active site
1195464011758	L-aspartate oxidase; Provisional; Region: PRK08071
1195464011759	L-aspartate oxidase; Provisional; Region: PRK06175
1195464011760	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1195464011761	cysteine desulfurase; Provisional; Region: PRK02948
1195464011762	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1195464011763	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464011764	catalytic residue [active]
1195464011765	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1195464011766	HTH domain; Region: HTH_11; pfam08279
1195464011767	3H domain; Region: 3H; pfam02829
1195464011768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1195464011769	MOSC domain; Region: MOSC; pfam03473
1195464011770	3-alpha domain; Region: 3-alpha; pfam03475
1195464011771	prephenate dehydratase; Provisional; Region: PRK11898
1195464011772	Prephenate dehydratase; Region: PDT; pfam00800
1195464011773	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1195464011774	putative L-Phe binding site [chemical binding]; other site
1195464011775	FtsX-like permease family; Region: FtsX; pfam02687
1195464011776	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464011777	FtsX-like permease family; Region: FtsX; pfam02687
1195464011778	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464011779	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464011780	Walker A/P-loop; other site
1195464011781	ATP binding site [chemical binding]; other site
1195464011782	Q-loop/lid; other site
1195464011783	ABC transporter signature motif; other site
1195464011784	Walker B; other site
1195464011785	D-loop; other site
1195464011786	H-loop/switch region; other site
1195464011787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464011788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1195464011789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464011790	ATP binding site [chemical binding]; other site
1195464011791	Mg2+ binding site [ion binding]; other site
1195464011792	G-X-G motif; other site
1195464011793	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464011794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464011795	active site
1195464011796	phosphorylation site [posttranslational modification]
1195464011797	intermolecular recognition site; other site
1195464011798	dimerization interface [polypeptide binding]; other site
1195464011799	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464011800	DNA binding site [nucleotide binding]
1195464011801	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1195464011802	GTP1/OBG; Region: GTP1_OBG; pfam01018
1195464011803	Obg GTPase; Region: Obg; cd01898
1195464011804	G1 box; other site
1195464011805	GTP/Mg2+ binding site [chemical binding]; other site
1195464011806	Switch I region; other site
1195464011807	G2 box; other site
1195464011808	G3 box; other site
1195464011809	Switch II region; other site
1195464011810	G4 box; other site
1195464011811	G5 box; other site
1195464011812	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1195464011813	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1195464011814	hypothetical protein; Provisional; Region: PRK14553
1195464011815	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1195464011816	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1195464011817	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1195464011818	homodimer interface [polypeptide binding]; other site
1195464011819	oligonucleotide binding site [chemical binding]; other site
1195464011820	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1195464011821	Peptidase family M50; Region: Peptidase_M50; pfam02163
1195464011822	active site
1195464011823	putative substrate binding region [chemical binding]; other site
1195464011824	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464011825	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464011826	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1195464011827	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1195464011828	Switch I; other site
1195464011829	Switch II; other site
1195464011830	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1195464011831	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1195464011832	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1195464011833	rod shape-determining protein MreC; Provisional; Region: PRK13922
1195464011834	rod shape-determining protein MreC; Region: MreC; pfam04085
1195464011835	rod shape-determining protein MreB; Provisional; Region: PRK13927
1195464011836	MreB and similar proteins; Region: MreB_like; cd10225
1195464011837	nucleotide binding site [chemical binding]; other site
1195464011838	Mg binding site [ion binding]; other site
1195464011839	putative protofilament interaction site [polypeptide binding]; other site
1195464011840	RodZ interaction site [polypeptide binding]; other site
1195464011841	hypothetical protein; Reviewed; Region: PRK00024
1195464011842	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1195464011843	MPN+ (JAMM) motif; other site
1195464011844	Zinc-binding site [ion binding]; other site
1195464011845	Maf-like protein; Region: Maf; pfam02545
1195464011846	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1195464011847	active site
1195464011848	dimer interface [polypeptide binding]; other site
1195464011849	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1195464011850	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1195464011851	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1195464011852	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1195464011853	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1195464011854	active site
1195464011855	HIGH motif; other site
1195464011856	nucleotide binding site [chemical binding]; other site
1195464011857	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1195464011858	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1195464011859	active site
1195464011860	KMSKS motif; other site
1195464011861	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1195464011862	tRNA binding surface [nucleotide binding]; other site
1195464011863	anticodon binding site; other site
1195464011864	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1195464011865	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
1195464011866	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
1195464011867	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
1195464011868	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1195464011869	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1195464011870	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464011871	inhibitor-cofactor binding pocket; inhibition site
1195464011872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464011873	catalytic residue [active]
1195464011874	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1195464011875	dimer interface [polypeptide binding]; other site
1195464011876	active site
1195464011877	Schiff base residues; other site
1195464011878	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1195464011879	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1195464011880	active site
1195464011881	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1195464011882	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1195464011883	domain interfaces; other site
1195464011884	active site
1195464011885	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1195464011886	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1195464011887	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1195464011888	tRNA; other site
1195464011889	putative tRNA binding site [nucleotide binding]; other site
1195464011890	putative NADP binding site [chemical binding]; other site
1195464011891	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1195464011892	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464011893	MarR family; Region: MarR; pfam01047
1195464011894	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1195464011895	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1195464011896	G1 box; other site
1195464011897	GTP/Mg2+ binding site [chemical binding]; other site
1195464011898	Switch I region; other site
1195464011899	G2 box; other site
1195464011900	G3 box; other site
1195464011901	Switch II region; other site
1195464011902	G4 box; other site
1195464011903	G5 box; other site
1195464011904	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1195464011905	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1195464011906	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1195464011907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464011908	Walker A motif; other site
1195464011909	ATP binding site [chemical binding]; other site
1195464011910	Walker B motif; other site
1195464011911	arginine finger; other site
1195464011912	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1195464011913	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1195464011914	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464011915	Walker A motif; other site
1195464011916	ATP binding site [chemical binding]; other site
1195464011917	Walker B motif; other site
1195464011918	arginine finger; other site
1195464011919	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1195464011920	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1195464011921	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1195464011922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464011923	Walker A motif; other site
1195464011924	ATP binding site [chemical binding]; other site
1195464011925	Walker B motif; other site
1195464011926	arginine finger; other site
1195464011927	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1195464011928	trigger factor; Provisional; Region: tig; PRK01490
1195464011929	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1195464011930	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1195464011931	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1195464011932	pentamer interface [polypeptide binding]; other site
1195464011933	dodecaamer interface [polypeptide binding]; other site
1195464011934	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
1195464011935	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1195464011936	active site
1195464011937	metal binding site [ion binding]; metal-binding site
1195464011938	homotetramer interface [polypeptide binding]; other site
1195464011939	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1195464011940	active site
1195464011941	dimerization interface [polypeptide binding]; other site
1195464011942	ribonuclease PH; Reviewed; Region: rph; PRK00173
1195464011943	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1195464011944	hexamer interface [polypeptide binding]; other site
1195464011945	active site
1195464011946	Sporulation and spore germination; Region: Germane; pfam10646
1195464011947	Spore germination protein [General function prediction only]; Region: COG5401
1195464011948	Sporulation and spore germination; Region: Germane; pfam10646
1195464011949	glutamate racemase; Provisional; Region: PRK00865
1195464011950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464011951	putative substrate translocation pore; other site
1195464011952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464011953	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1195464011954	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1195464011955	potential catalytic triad [active]
1195464011956	conserved cys residue [active]
1195464011957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464011958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464011959	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1195464011960	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1195464011961	potential catalytic triad [active]
1195464011962	conserved cys residue [active]
1195464011963	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464011964	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464011965	DNA binding residues [nucleotide binding]
1195464011966	dimerization interface [polypeptide binding]; other site
1195464011967	putative uracil/xanthine transporter; Provisional; Region: PRK11412
1195464011968	putative deaminase; Validated; Region: PRK06846
1195464011969	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1195464011970	active site
1195464011971	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
1195464011972	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1195464011973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464011974	non-specific DNA binding site [nucleotide binding]; other site
1195464011975	salt bridge; other site
1195464011976	sequence-specific DNA binding site [nucleotide binding]; other site
1195464011977	Cupin domain; Region: Cupin_2; pfam07883
1195464011978	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1195464011979	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1195464011980	amphipathic channel; other site
1195464011981	Asn-Pro-Ala signature motifs; other site
1195464011982	Predicted transcriptional regulator [Transcription]; Region: COG1959
1195464011983	Transcriptional regulator; Region: Rrf2; pfam02082
1195464011984	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1195464011985	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1195464011986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464011987	Walker A/P-loop; other site
1195464011988	ATP binding site [chemical binding]; other site
1195464011989	Q-loop/lid; other site
1195464011990	ABC transporter signature motif; other site
1195464011991	Walker B; other site
1195464011992	D-loop; other site
1195464011993	H-loop/switch region; other site
1195464011994	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1195464011995	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464011996	active site
1195464011997	motif I; other site
1195464011998	motif II; other site
1195464011999	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1195464012000	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1195464012001	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
1195464012002	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1195464012003	ligand binding site [chemical binding]; other site
1195464012004	flagellar motor protein MotA; Validated; Region: PRK08124
1195464012005	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1195464012006	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1195464012007	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1195464012008	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1195464012009	active site
1195464012010	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1195464012011	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1195464012012	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1195464012013	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1195464012014	L-aspartate oxidase; Provisional; Region: PRK06175
1195464012015	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1195464012016	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
1195464012017	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1195464012018	putative Iron-sulfur protein interface [polypeptide binding]; other site
1195464012019	proximal heme binding site [chemical binding]; other site
1195464012020	distal heme binding site [chemical binding]; other site
1195464012021	putative dimer interface [polypeptide binding]; other site
1195464012022	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1195464012023	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1195464012024	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1195464012025	GIY-YIG motif/motif A; other site
1195464012026	active site
1195464012027	catalytic site [active]
1195464012028	putative DNA binding site [nucleotide binding]; other site
1195464012029	metal binding site [ion binding]; metal-binding site
1195464012030	UvrB/uvrC motif; Region: UVR; pfam02151
1195464012031	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1195464012032	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464012033	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1195464012034	catalytic residues [active]
1195464012035	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1195464012036	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1195464012037	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1195464012038	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1195464012039	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1195464012040	Ligand binding site [chemical binding]; other site
1195464012041	enoyl-CoA hydratase; Provisional; Region: PRK07658
1195464012042	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1195464012043	substrate binding site [chemical binding]; other site
1195464012044	oxyanion hole (OAH) forming residues; other site
1195464012045	trimer interface [polypeptide binding]; other site
1195464012046	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1195464012047	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464012048	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464012049	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1195464012050	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1195464012051	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1195464012052	acyl-activating enzyme (AAE) consensus motif; other site
1195464012053	putative AMP binding site [chemical binding]; other site
1195464012054	putative active site [active]
1195464012055	putative CoA binding site [chemical binding]; other site
1195464012056	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1195464012057	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1195464012058	siderophore binding site; other site
1195464012059	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464012060	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464012061	ABC-ATPase subunit  interface; other site
1195464012062	dimer interface [polypeptide binding]; other site
1195464012063	putative PBP binding regions; other site
1195464012064	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464012065	ABC-ATPase subunit  interface; other site
1195464012066	dimer interface [polypeptide binding]; other site
1195464012067	putative PBP binding regions; other site
1195464012068	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
1195464012069	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464012070	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464012071	DNA binding residues [nucleotide binding]
1195464012072	DinB family; Region: DinB; pfam05163
1195464012073	DinB superfamily; Region: DinB_2; pfam12867
1195464012074	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1195464012075	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1195464012076	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1195464012077	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1195464012078	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1195464012079	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464012080	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1195464012081	Walker A/P-loop; other site
1195464012082	ATP binding site [chemical binding]; other site
1195464012083	Q-loop/lid; other site
1195464012084	ABC transporter signature motif; other site
1195464012085	Walker B; other site
1195464012086	D-loop; other site
1195464012087	H-loop/switch region; other site
1195464012088	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464012089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464012090	dimer interface [polypeptide binding]; other site
1195464012091	phosphorylation site [posttranslational modification]
1195464012092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012093	ATP binding site [chemical binding]; other site
1195464012094	Mg2+ binding site [ion binding]; other site
1195464012095	G-X-G motif; other site
1195464012096	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464012097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464012098	active site
1195464012099	phosphorylation site [posttranslational modification]
1195464012100	intermolecular recognition site; other site
1195464012101	dimerization interface [polypeptide binding]; other site
1195464012102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464012103	DNA binding site [nucleotide binding]
1195464012104	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
1195464012105	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1195464012106	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1195464012107	putative RNA binding site [nucleotide binding]; other site
1195464012108	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314
1195464012109	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1195464012110	active site
1195464012111	catalytic site [active]
1195464012112	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1195464012113	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1195464012114	Walker A/P-loop; other site
1195464012115	ATP binding site [chemical binding]; other site
1195464012116	Q-loop/lid; other site
1195464012117	ABC transporter signature motif; other site
1195464012118	Walker B; other site
1195464012119	D-loop; other site
1195464012120	H-loop/switch region; other site
1195464012121	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1195464012122	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464012123	ABC-ATPase subunit  interface; other site
1195464012124	dimer interface [polypeptide binding]; other site
1195464012125	putative PBP binding regions; other site
1195464012126	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
1195464012127	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1195464012128	intersubunit interface [polypeptide binding]; other site
1195464012129	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012130	heme-binding site [chemical binding]; other site
1195464012131	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012132	heme-binding site [chemical binding]; other site
1195464012133	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012134	heme-binding site [chemical binding]; other site
1195464012135	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012136	heme-binding site [chemical binding]; other site
1195464012137	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012138	heme-binding site [chemical binding]; other site
1195464012139	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012140	heme-binding site [chemical binding]; other site
1195464012141	heme uptake protein IsdC; Region: IsdC; TIGR03656
1195464012142	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464012143	heme-binding site [chemical binding]; other site
1195464012144	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
1195464012145	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464012146	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1195464012147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464012148	RNA binding surface [nucleotide binding]; other site
1195464012149	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1195464012150	probable active site [active]
1195464012151	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1195464012152	MutS domain III; Region: MutS_III; pfam05192
1195464012153	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1195464012154	Walker A/P-loop; other site
1195464012155	ATP binding site [chemical binding]; other site
1195464012156	Q-loop/lid; other site
1195464012157	ABC transporter signature motif; other site
1195464012158	Walker B; other site
1195464012159	D-loop; other site
1195464012160	H-loop/switch region; other site
1195464012161	Smr domain; Region: Smr; pfam01713
1195464012162	hypothetical protein; Provisional; Region: PRK08609
1195464012163	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
1195464012164	active site
1195464012165	primer binding site [nucleotide binding]; other site
1195464012166	NTP  binding site [chemical binding]; other site
1195464012167	metal binding triad [ion binding]; metal-binding site
1195464012168	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1195464012169	active site
1195464012170	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1195464012171	Colicin V production protein; Region: Colicin_V; pfam02674
1195464012172	Cell division protein ZapA; Region: ZapA; cl01146
1195464012173	ribonuclease HIII; Provisional; Region: PRK00996
1195464012174	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1195464012175	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1195464012176	RNA/DNA hybrid binding site [nucleotide binding]; other site
1195464012177	active site
1195464012178	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1195464012179	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464012180	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1195464012181	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1195464012182	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1195464012183	putative dimer interface [polypeptide binding]; other site
1195464012184	putative anticodon binding site; other site
1195464012185	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1195464012186	homodimer interface [polypeptide binding]; other site
1195464012187	motif 1; other site
1195464012188	motif 2; other site
1195464012189	active site
1195464012190	motif 3; other site
1195464012191	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1195464012192	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1195464012193	putative tRNA-binding site [nucleotide binding]; other site
1195464012194	B3/4 domain; Region: B3_4; pfam03483
1195464012195	tRNA synthetase B5 domain; Region: B5; smart00874
1195464012196	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1195464012197	dimer interface [polypeptide binding]; other site
1195464012198	motif 1; other site
1195464012199	motif 3; other site
1195464012200	motif 2; other site
1195464012201	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1195464012202	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1195464012203	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1195464012204	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1195464012205	dimer interface [polypeptide binding]; other site
1195464012206	motif 1; other site
1195464012207	active site
1195464012208	motif 2; other site
1195464012209	motif 3; other site
1195464012210	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1195464012211	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1195464012212	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1195464012213	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
1195464012214	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464012215	Zn2+ binding site [ion binding]; other site
1195464012216	Mg2+ binding site [ion binding]; other site
1195464012217	CAAX protease self-immunity; Region: Abi; pfam02517
1195464012218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464012219	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1195464012220	putative substrate translocation pore; other site
1195464012221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464012222	HlyD family secretion protein; Region: HlyD_3; pfam13437
1195464012223	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1195464012224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464012225	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1195464012226	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1195464012227	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1195464012228	oligomer interface [polypeptide binding]; other site
1195464012229	active site
1195464012230	metal binding site [ion binding]; metal-binding site
1195464012231	dUTPase; Region: dUTPase_2; pfam08761
1195464012232	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1195464012233	active site
1195464012234	homodimer interface [polypeptide binding]; other site
1195464012235	metal binding site [ion binding]; metal-binding site
1195464012236	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1195464012237	23S rRNA binding site [nucleotide binding]; other site
1195464012238	L21 binding site [polypeptide binding]; other site
1195464012239	L13 binding site [polypeptide binding]; other site
1195464012240	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1195464012241	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1195464012242	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1195464012243	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1195464012244	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1195464012245	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1195464012246	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1195464012247	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1195464012248	active site
1195464012249	dimer interface [polypeptide binding]; other site
1195464012250	motif 1; other site
1195464012251	motif 2; other site
1195464012252	motif 3; other site
1195464012253	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1195464012254	anticodon binding site; other site
1195464012255	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
1195464012256	primosomal protein DnaI; Reviewed; Region: PRK08939
1195464012257	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1195464012258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464012259	Walker A motif; other site
1195464012260	ATP binding site [chemical binding]; other site
1195464012261	Walker B motif; other site
1195464012262	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1195464012263	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1195464012264	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1195464012265	ATP cone domain; Region: ATP-cone; pfam03477
1195464012266	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
1195464012267	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
1195464012268	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1195464012269	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1195464012270	dephospho-CoA kinase; Region: TIGR00152
1195464012271	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1195464012272	CoA-binding site [chemical binding]; other site
1195464012273	ATP-binding [chemical binding]; other site
1195464012274	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1195464012275	Domain of unknown function DUF; Region: DUF204; pfam02659
1195464012276	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1195464012277	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1195464012278	DNA binding site [nucleotide binding]
1195464012279	catalytic residue [active]
1195464012280	H2TH interface [polypeptide binding]; other site
1195464012281	putative catalytic residues [active]
1195464012282	turnover-facilitating residue; other site
1195464012283	intercalation triad [nucleotide binding]; other site
1195464012284	8OG recognition residue [nucleotide binding]; other site
1195464012285	putative reading head residues; other site
1195464012286	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1195464012287	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1195464012288	DNA polymerase I; Provisional; Region: PRK05755
1195464012289	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1195464012290	active site
1195464012291	metal binding site 1 [ion binding]; metal-binding site
1195464012292	putative 5' ssDNA interaction site; other site
1195464012293	metal binding site 3; metal-binding site
1195464012294	metal binding site 2 [ion binding]; metal-binding site
1195464012295	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1195464012296	putative DNA binding site [nucleotide binding]; other site
1195464012297	putative metal binding site [ion binding]; other site
1195464012298	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1195464012299	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1195464012300	active site
1195464012301	DNA binding site [nucleotide binding]
1195464012302	catalytic site [active]
1195464012303	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464012304	dimerization interface [polypeptide binding]; other site
1195464012305	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1195464012306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464012307	putative active site [active]
1195464012308	heme pocket [chemical binding]; other site
1195464012309	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464012310	dimer interface [polypeptide binding]; other site
1195464012311	phosphorylation site [posttranslational modification]
1195464012312	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012313	ATP binding site [chemical binding]; other site
1195464012314	Mg2+ binding site [ion binding]; other site
1195464012315	G-X-G motif; other site
1195464012316	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464012317	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464012318	active site
1195464012319	phosphorylation site [posttranslational modification]
1195464012320	intermolecular recognition site; other site
1195464012321	dimerization interface [polypeptide binding]; other site
1195464012322	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464012323	DNA binding site [nucleotide binding]
1195464012324	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1195464012325	active site 2 [active]
1195464012326	active site 1 [active]
1195464012327	malate dehydrogenase; Reviewed; Region: PRK06223
1195464012328	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1195464012329	NAD(P) binding site [chemical binding]; other site
1195464012330	dimer interface [polypeptide binding]; other site
1195464012331	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464012332	substrate binding site [chemical binding]; other site
1195464012333	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1195464012334	isocitrate dehydrogenase; Validated; Region: PRK07362
1195464012335	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1195464012336	dimer interface [polypeptide binding]; other site
1195464012337	Citrate synthase; Region: Citrate_synt; pfam00285
1195464012338	active site
1195464012339	citrylCoA binding site [chemical binding]; other site
1195464012340	oxalacetate/citrate binding site [chemical binding]; other site
1195464012341	coenzyme A binding site [chemical binding]; other site
1195464012342	catalytic triad [active]
1195464012343	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1195464012344	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1195464012345	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
1195464012346	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1195464012347	pyruvate kinase; Provisional; Region: PRK06354
1195464012348	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1195464012349	domain interfaces; other site
1195464012350	active site
1195464012351	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1195464012352	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1195464012353	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1195464012354	active site
1195464012355	ADP/pyrophosphate binding site [chemical binding]; other site
1195464012356	dimerization interface [polypeptide binding]; other site
1195464012357	allosteric effector site; other site
1195464012358	fructose-1,6-bisphosphate binding site; other site
1195464012359	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1195464012360	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1195464012361	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1195464012362	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1195464012363	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1195464012364	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1195464012365	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464012366	DNA-binding site [nucleotide binding]; DNA binding site
1195464012367	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1195464012368	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1195464012369	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1195464012370	putative NAD(P) binding site [chemical binding]; other site
1195464012371	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
1195464012372	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1195464012373	active site
1195464012374	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1195464012375	generic binding surface II; other site
1195464012376	generic binding surface I; other site
1195464012377	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
1195464012378	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1195464012379	DHH family; Region: DHH; pfam01368
1195464012380	DHHA1 domain; Region: DHHA1; pfam02272
1195464012381	YtpI-like protein; Region: YtpI; pfam14007
1195464012382	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
1195464012383	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1195464012384	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464012385	DNA-binding site [nucleotide binding]; DNA binding site
1195464012386	DRTGG domain; Region: DRTGG; pfam07085
1195464012387	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1195464012388	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1195464012389	active site 2 [active]
1195464012390	active site 1 [active]
1195464012391	metal-dependent hydrolase; Provisional; Region: PRK00685
1195464012392	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1195464012393	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1195464012394	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1195464012395	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1195464012396	active site
1195464012397	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
1195464012398	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1195464012399	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
1195464012400	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464012401	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1195464012402	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1195464012403	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1195464012404	hexamer interface [polypeptide binding]; other site
1195464012405	ligand binding site [chemical binding]; other site
1195464012406	putative active site [active]
1195464012407	NAD(P) binding site [chemical binding]; other site
1195464012408	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1195464012409	classical (c) SDRs; Region: SDR_c; cd05233
1195464012410	NAD(P) binding site [chemical binding]; other site
1195464012411	active site
1195464012412	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1195464012413	Ligand Binding Site [chemical binding]; other site
1195464012414	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464012415	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1195464012416	DinB superfamily; Region: DinB_2; pfam12867
1195464012417	argininosuccinate lyase; Provisional; Region: PRK00855
1195464012418	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1195464012419	active sites [active]
1195464012420	tetramer interface [polypeptide binding]; other site
1195464012421	argininosuccinate synthase; Provisional; Region: PRK13820
1195464012422	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1195464012423	ANP binding site [chemical binding]; other site
1195464012424	Substrate Binding Site II [chemical binding]; other site
1195464012425	Substrate Binding Site I [chemical binding]; other site
1195464012426	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464012427	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464012428	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464012429	EcsC protein family; Region: EcsC; pfam12787
1195464012430	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1195464012431	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1195464012432	nudix motif; other site
1195464012433	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1195464012434	propionate/acetate kinase; Provisional; Region: PRK12379
1195464012435	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1195464012436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464012437	S-adenosylmethionine binding site [chemical binding]; other site
1195464012438	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1195464012439	dimer interface [polypeptide binding]; other site
1195464012440	catalytic triad [active]
1195464012441	peroxidatic and resolving cysteines [active]
1195464012442	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1195464012443	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1195464012444	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
1195464012445	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1195464012446	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1195464012447	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1195464012448	active site
1195464012449	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464012450	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1195464012451	dimer interface [polypeptide binding]; other site
1195464012452	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1195464012453	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
1195464012454	active site
1195464012455	acyl-activating enzyme (AAE) consensus motif; other site
1195464012456	putative CoA binding site [chemical binding]; other site
1195464012457	AMP binding site [chemical binding]; other site
1195464012458	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1195464012459	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1195464012460	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1195464012461	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1195464012462	Ligand Binding Site [chemical binding]; other site
1195464012463	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1195464012464	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1195464012465	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464012466	catalytic residue [active]
1195464012467	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1195464012468	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464012469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464012470	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1195464012471	dimerization interface [polypeptide binding]; other site
1195464012472	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464012473	EamA-like transporter family; Region: EamA; pfam00892
1195464012474	EamA-like transporter family; Region: EamA; pfam00892
1195464012475	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464012476	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464012477	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1195464012478	GAF domain; Region: GAF_2; pfam13185
1195464012479	methionine gamma-lyase; Provisional; Region: PRK06767
1195464012480	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1195464012481	homodimer interface [polypeptide binding]; other site
1195464012482	substrate-cofactor binding pocket; other site
1195464012483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464012484	catalytic residue [active]
1195464012485	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1195464012486	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1195464012487	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464012488	RNA binding surface [nucleotide binding]; other site
1195464012489	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1195464012490	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1195464012491	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
1195464012492	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1195464012493	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
1195464012494	active site
1195464012495	HIGH motif; other site
1195464012496	dimer interface [polypeptide binding]; other site
1195464012497	KMSKS motif; other site
1195464012498	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464012499	RNA binding surface [nucleotide binding]; other site
1195464012500	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1195464012501	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464012502	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464012503	DNA binding residues [nucleotide binding]
1195464012504	maltose O-acetyltransferase; Provisional; Region: PRK10092
1195464012505	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1195464012506	active site
1195464012507	substrate binding site [chemical binding]; other site
1195464012508	trimer interface [polypeptide binding]; other site
1195464012509	CoA binding site [chemical binding]; other site
1195464012510	acetyl-CoA synthetase; Provisional; Region: PRK04319
1195464012511	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1195464012512	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1195464012513	active site
1195464012514	acyl-activating enzyme (AAE) consensus motif; other site
1195464012515	putative CoA binding site [chemical binding]; other site
1195464012516	AMP binding site [chemical binding]; other site
1195464012517	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464012518	Coenzyme A binding pocket [chemical binding]; other site
1195464012519	FOG: CBS domain [General function prediction only]; Region: COG0517
1195464012520	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
1195464012521	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
1195464012522	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1195464012523	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1195464012524	active site
1195464012525	Zn binding site [ion binding]; other site
1195464012526	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1195464012527	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464012528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464012529	active site
1195464012530	phosphorylation site [posttranslational modification]
1195464012531	intermolecular recognition site; other site
1195464012532	dimerization interface [polypeptide binding]; other site
1195464012533	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464012534	DNA binding site [nucleotide binding]
1195464012535	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464012536	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464012537	dimerization interface [polypeptide binding]; other site
1195464012538	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464012539	dimer interface [polypeptide binding]; other site
1195464012540	phosphorylation site [posttranslational modification]
1195464012541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012542	ATP binding site [chemical binding]; other site
1195464012543	Mg2+ binding site [ion binding]; other site
1195464012544	G-X-G motif; other site
1195464012545	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1195464012546	Ankyrin repeat; Region: Ank; pfam00023
1195464012547	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1195464012548	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1195464012549	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1195464012550	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1195464012551	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1195464012552	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
1195464012553	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1195464012554	Protein of unknown function (DUF3917); Region: DUF3917; pfam13055
1195464012555	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
1195464012556	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
1195464012557	catabolite control protein A; Region: ccpA; TIGR01481
1195464012558	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464012559	DNA binding site [nucleotide binding]
1195464012560	domain linker motif; other site
1195464012561	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1195464012562	dimerization interface [polypeptide binding]; other site
1195464012563	effector binding site; other site
1195464012564	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1195464012565	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1195464012566	putative dimer interface [polypeptide binding]; other site
1195464012567	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1195464012568	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1195464012569	putative dimer interface [polypeptide binding]; other site
1195464012570	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
1195464012571	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1195464012572	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1195464012573	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1195464012574	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1195464012575	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1195464012576	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464012577	Coenzyme A binding pocket [chemical binding]; other site
1195464012578	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464012579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464012580	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464012581	EamA-like transporter family; Region: EamA; pfam00892
1195464012582	EamA-like transporter family; Region: EamA; pfam00892
1195464012583	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1195464012584	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464012585	DNA binding residues [nucleotide binding]
1195464012586	putative dimer interface [polypeptide binding]; other site
1195464012587	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1195464012588	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1195464012589	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1195464012590	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1195464012591	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
1195464012592	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
1195464012593	active site
1195464012594	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1195464012595	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464012596	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1195464012597	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1195464012598	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1195464012599	active site
1195464012600	metal binding site [ion binding]; metal-binding site
1195464012601	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1195464012602	putative tRNA-binding site [nucleotide binding]; other site
1195464012603	hypothetical protein; Provisional; Region: PRK13668
1195464012604	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464012605	catalytic residues [active]
1195464012606	NTPase; Reviewed; Region: PRK03114
1195464012607	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1195464012608	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1195464012609	oligomer interface [polypeptide binding]; other site
1195464012610	active site
1195464012611	metal binding site [ion binding]; metal-binding site
1195464012612	Predicted small secreted protein [Function unknown]; Region: COG5584
1195464012613	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464012614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464012615	S-adenosylmethionine binding site [chemical binding]; other site
1195464012616	YtzH-like protein; Region: YtzH; pfam14165
1195464012617	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464012618	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1195464012619	active site
1195464012620	substrate binding site [chemical binding]; other site
1195464012621	ATP binding site [chemical binding]; other site
1195464012622	pullulanase, type I; Region: pulA_typeI; TIGR02104
1195464012623	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1195464012624	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1195464012625	Ca binding site [ion binding]; other site
1195464012626	active site
1195464012627	catalytic site [active]
1195464012628	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1195464012629	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1195464012630	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1195464012631	dipeptidase PepV; Reviewed; Region: PRK07318
1195464012632	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1195464012633	active site
1195464012634	metal binding site [ion binding]; metal-binding site
1195464012635	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1195464012636	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1195464012637	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464012638	RNA binding surface [nucleotide binding]; other site
1195464012639	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1195464012640	active site
1195464012641	uracil binding [chemical binding]; other site
1195464012642	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1195464012643	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1195464012644	HI0933-like protein; Region: HI0933_like; pfam03486
1195464012645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464012646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464012647	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1195464012648	putative substrate translocation pore; other site
1195464012649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464012650	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464012651	dimerization interface [polypeptide binding]; other site
1195464012652	putative DNA binding site [nucleotide binding]; other site
1195464012653	putative Zn2+ binding site [ion binding]; other site
1195464012654	Slx4 endonuclease; Region: Slx4; pfam09494
1195464012655	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1195464012656	putative hydrophobic ligand binding site [chemical binding]; other site
1195464012657	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
1195464012658	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
1195464012659	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
1195464012660	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1195464012661	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1195464012662	NAD binding site [chemical binding]; other site
1195464012663	homodimer interface [polypeptide binding]; other site
1195464012664	active site
1195464012665	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1195464012666	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1195464012667	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
1195464012668	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1195464012669	MoaE interaction surface [polypeptide binding]; other site
1195464012670	MoeB interaction surface [polypeptide binding]; other site
1195464012671	thiocarboxylated glycine; other site
1195464012672	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1195464012673	MoaE homodimer interface [polypeptide binding]; other site
1195464012674	MoaD interaction [polypeptide binding]; other site
1195464012675	active site residues [active]
1195464012676	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1195464012677	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1195464012678	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1195464012679	dimer interface [polypeptide binding]; other site
1195464012680	putative functional site; other site
1195464012681	putative MPT binding site; other site
1195464012682	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1195464012683	trimer interface [polypeptide binding]; other site
1195464012684	dimer interface [polypeptide binding]; other site
1195464012685	putative active site [active]
1195464012686	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
1195464012687	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1195464012688	ATP binding site [chemical binding]; other site
1195464012689	substrate interface [chemical binding]; other site
1195464012690	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1195464012691	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464012692	FeS/SAM binding site; other site
1195464012693	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1195464012694	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1195464012695	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1195464012696	active site residue [active]
1195464012697	homoserine O-acetyltransferase; Provisional; Region: PRK06765
1195464012698	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1195464012699	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464012700	Spore germination protein; Region: Spore_permease; pfam03845
1195464012701	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464012702	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464012703	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
1195464012704	putative nucleotide binding site [chemical binding]; other site
1195464012705	putative metal binding site [ion binding]; other site
1195464012706	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1195464012707	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1195464012708	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1195464012709	HIGH motif; other site
1195464012710	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1195464012711	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1195464012712	active site
1195464012713	KMSKS motif; other site
1195464012714	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1195464012715	tRNA binding surface [nucleotide binding]; other site
1195464012716	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464012717	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464012718	putative substrate translocation pore; other site
1195464012719	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1195464012720	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1195464012721	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1195464012722	TrkA-C domain; Region: TrkA_C; pfam02080
1195464012723	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1195464012724	Int/Topo IB signature motif; other site
1195464012725	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464012726	FtsX-like permease family; Region: FtsX; pfam02687
1195464012727	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464012728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464012729	Walker A/P-loop; other site
1195464012730	ATP binding site [chemical binding]; other site
1195464012731	Q-loop/lid; other site
1195464012732	ABC transporter signature motif; other site
1195464012733	Walker B; other site
1195464012734	D-loop; other site
1195464012735	H-loop/switch region; other site
1195464012736	Protein of unknown function (DUF418); Region: DUF418; cl12135
1195464012737	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1195464012738	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
1195464012739	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1195464012740	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464012741	FeS/SAM binding site; other site
1195464012742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464012743	S-adenosylmethionine binding site [chemical binding]; other site
1195464012744	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1195464012745	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464012746	Walker A/P-loop; other site
1195464012747	ATP binding site [chemical binding]; other site
1195464012748	Q-loop/lid; other site
1195464012749	ABC transporter signature motif; other site
1195464012750	Walker B; other site
1195464012751	D-loop; other site
1195464012752	H-loop/switch region; other site
1195464012753	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1195464012754	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1195464012755	Domain of unknown function DUF21; Region: DUF21; pfam01595
1195464012756	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1195464012757	Transporter associated domain; Region: CorC_HlyC; pfam03471
1195464012758	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464012759	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464012760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1195464012761	Predicted esterase [General function prediction only]; Region: COG0400
1195464012762	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
1195464012763	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
1195464012764	active site
1195464012765	zinc binding site [ion binding]; other site
1195464012766	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464012767	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464012768	active site
1195464012769	catalytic tetrad [active]
1195464012770	type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898
1195464012771	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1195464012772	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1195464012773	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1195464012774	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
1195464012775	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1195464012776	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1195464012777	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1195464012778	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1195464012779	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1195464012780	trimer interface [polypeptide binding]; other site
1195464012781	putative metal binding site [ion binding]; other site
1195464012782	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1195464012783	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1195464012784	active site
1195464012785	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464012786	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1195464012787	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1195464012788	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1195464012789	GTP binding site; other site
1195464012790	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1195464012791	MPT binding site; other site
1195464012792	trimer interface [polypeptide binding]; other site
1195464012793	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1195464012794	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1195464012795	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1195464012796	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1195464012797	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1195464012798	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1195464012799	active site
1195464012800	substrate-binding site [chemical binding]; other site
1195464012801	metal-binding site [ion binding]
1195464012802	ATP binding site [chemical binding]; other site
1195464012803	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1195464012804	EamA-like transporter family; Region: EamA; pfam00892
1195464012805	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464012806	EamA-like transporter family; Region: EamA; pfam00892
1195464012807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1195464012808	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1195464012809	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1195464012810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464012811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012812	ATP binding site [chemical binding]; other site
1195464012813	Mg2+ binding site [ion binding]; other site
1195464012814	G-X-G motif; other site
1195464012815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464012816	dimer interface [polypeptide binding]; other site
1195464012817	phosphorylation site [posttranslational modification]
1195464012818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012819	ATP binding site [chemical binding]; other site
1195464012820	Mg2+ binding site [ion binding]; other site
1195464012821	G-X-G motif; other site
1195464012822	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1195464012823	heme binding pocket [chemical binding]; other site
1195464012824	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1195464012825	Sulfatase; Region: Sulfatase; pfam00884
1195464012826	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
1195464012827	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1195464012828	NMT1-like family; Region: NMT1_2; pfam13379
1195464012829	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1195464012830	Walker A/P-loop; other site
1195464012831	ATP binding site [chemical binding]; other site
1195464012832	ABC transporter; Region: ABC_tran; pfam00005
1195464012833	Q-loop/lid; other site
1195464012834	ABC transporter signature motif; other site
1195464012835	Walker B; other site
1195464012836	D-loop; other site
1195464012837	H-loop/switch region; other site
1195464012838	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1195464012839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464012840	dimer interface [polypeptide binding]; other site
1195464012841	conserved gate region; other site
1195464012842	putative PBP binding loops; other site
1195464012843	ABC-ATPase subunit interface; other site
1195464012844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464012845	motif II; other site
1195464012846	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1195464012847	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
1195464012848	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
1195464012849	nudix motif; other site
1195464012850	Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606
1195464012851	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
1195464012852	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1195464012853	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1195464012854	active site clefts [active]
1195464012855	zinc binding site [ion binding]; other site
1195464012856	dimer interface [polypeptide binding]; other site
1195464012857	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1195464012858	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1195464012859	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1195464012860	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1195464012861	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1195464012862	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1195464012863	putative active site [active]
1195464012864	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464012865	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464012866	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464012867	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464012868	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1195464012869	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1195464012870	Predicted membrane protein [Function unknown]; Region: COG3766
1195464012871	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1195464012872	hypothetical protein; Provisional; Region: PRK12473
1195464012873	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1195464012874	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1195464012875	G1 box; other site
1195464012876	GTP/Mg2+ binding site [chemical binding]; other site
1195464012877	Switch I region; other site
1195464012878	G2 box; other site
1195464012879	G3 box; other site
1195464012880	Switch II region; other site
1195464012881	G4 box; other site
1195464012882	G5 box; other site
1195464012883	Nucleoside recognition; Region: Gate; pfam07670
1195464012884	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1195464012885	Nucleoside recognition; Region: Gate; pfam07670
1195464012886	FeoA domain; Region: FeoA; pfam04023
1195464012887	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
1195464012888	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464012889	dimerization interface [polypeptide binding]; other site
1195464012890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464012891	dimer interface [polypeptide binding]; other site
1195464012892	phosphorylation site [posttranslational modification]
1195464012893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012894	ATP binding site [chemical binding]; other site
1195464012895	Mg2+ binding site [ion binding]; other site
1195464012896	G-X-G motif; other site
1195464012897	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464012898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464012899	active site
1195464012900	phosphorylation site [posttranslational modification]
1195464012901	intermolecular recognition site; other site
1195464012902	dimerization interface [polypeptide binding]; other site
1195464012903	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464012904	DNA binding site [nucleotide binding]
1195464012905	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
1195464012906	active site
1195464012907	catalytic site [active]
1195464012908	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464012909	active site
1195464012910	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1195464012911	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1195464012912	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
1195464012913	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
1195464012914	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
1195464012915	FtsX-like permease family; Region: FtsX; pfam02687
1195464012916	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464012917	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464012918	Walker A/P-loop; other site
1195464012919	ATP binding site [chemical binding]; other site
1195464012920	Q-loop/lid; other site
1195464012921	ABC transporter signature motif; other site
1195464012922	Walker B; other site
1195464012923	D-loop; other site
1195464012924	H-loop/switch region; other site
1195464012925	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1195464012926	putative hydrophobic ligand binding site [chemical binding]; other site
1195464012927	protein interface [polypeptide binding]; other site
1195464012928	gate; other site
1195464012929	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464012930	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464012931	active site
1195464012932	catalytic tetrad [active]
1195464012933	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464012934	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464012935	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464012936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464012937	S-adenosylmethionine binding site [chemical binding]; other site
1195464012938	FtsX-like permease family; Region: FtsX; pfam02687
1195464012939	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464012940	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464012941	Walker A/P-loop; other site
1195464012942	ATP binding site [chemical binding]; other site
1195464012943	Q-loop/lid; other site
1195464012944	ABC transporter signature motif; other site
1195464012945	Walker B; other site
1195464012946	D-loop; other site
1195464012947	H-loop/switch region; other site
1195464012948	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1195464012949	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464012950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1195464012951	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1195464012952	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464012953	Walker A/P-loop; other site
1195464012954	ATP binding site [chemical binding]; other site
1195464012955	Q-loop/lid; other site
1195464012956	ABC transporter signature motif; other site
1195464012957	Walker B; other site
1195464012958	D-loop; other site
1195464012959	H-loop/switch region; other site
1195464012960	Predicted integral membrane protein [Function unknown]; Region: COG5658
1195464012961	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1195464012962	SdpI/YhfL protein family; Region: SdpI; pfam13630
1195464012963	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464012964	dimerization interface [polypeptide binding]; other site
1195464012965	putative DNA binding site [nucleotide binding]; other site
1195464012966	putative Zn2+ binding site [ion binding]; other site
1195464012967	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1195464012968	RNA polymerase sigma factor; Provisional; Region: PRK12543
1195464012969	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464012970	DNA binding residues [nucleotide binding]
1195464012971	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464012972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464012973	active site
1195464012974	phosphorylation site [posttranslational modification]
1195464012975	intermolecular recognition site; other site
1195464012976	dimerization interface [polypeptide binding]; other site
1195464012977	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464012978	DNA binding site [nucleotide binding]
1195464012979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464012980	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1195464012981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464012982	ATP binding site [chemical binding]; other site
1195464012983	Mg2+ binding site [ion binding]; other site
1195464012984	G-X-G motif; other site
1195464012985	FtsX-like permease family; Region: FtsX; pfam02687
1195464012986	FtsX-like permease family; Region: FtsX; pfam02687
1195464012987	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464012988	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464012989	Walker A/P-loop; other site
1195464012990	ATP binding site [chemical binding]; other site
1195464012991	Q-loop/lid; other site
1195464012992	ABC transporter signature motif; other site
1195464012993	Walker B; other site
1195464012994	D-loop; other site
1195464012995	H-loop/switch region; other site
1195464012996	FtsX-like permease family; Region: FtsX; pfam02687
1195464012997	GntP family permease; Region: GntP_permease; pfam02447
1195464012998	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1195464012999	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1195464013000	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464013001	DNA-binding site [nucleotide binding]; DNA binding site
1195464013002	UTRA domain; Region: UTRA; pfam07702
1195464013003	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1195464013004	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1195464013005	substrate binding site [chemical binding]; other site
1195464013006	ATP binding site [chemical binding]; other site
1195464013007	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1195464013008	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1195464013009	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464013010	catalytic residue [active]
1195464013011	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
1195464013012	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1195464013013	active site
1195464013014	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1195464013015	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1195464013016	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1195464013017	dimerization interface [polypeptide binding]; other site
1195464013018	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464013019	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464013020	dimer interface [polypeptide binding]; other site
1195464013021	phosphorylation site [posttranslational modification]
1195464013022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464013023	ATP binding site [chemical binding]; other site
1195464013024	Mg2+ binding site [ion binding]; other site
1195464013025	G-X-G motif; other site
1195464013026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464013027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464013028	active site
1195464013029	phosphorylation site [posttranslational modification]
1195464013030	intermolecular recognition site; other site
1195464013031	dimerization interface [polypeptide binding]; other site
1195464013032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464013033	DNA binding site [nucleotide binding]
1195464013034	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
1195464013035	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1195464013036	active site
1195464013037	octamer interface [polypeptide binding]; other site
1195464013038	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1195464013039	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1195464013040	acyl-activating enzyme (AAE) consensus motif; other site
1195464013041	putative AMP binding site [chemical binding]; other site
1195464013042	putative active site [active]
1195464013043	putative CoA binding site [chemical binding]; other site
1195464013044	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1195464013045	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1195464013046	substrate binding site [chemical binding]; other site
1195464013047	oxyanion hole (OAH) forming residues; other site
1195464013048	trimer interface [polypeptide binding]; other site
1195464013049	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1195464013050	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1195464013051	nucleophilic elbow; other site
1195464013052	catalytic triad; other site
1195464013053	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1195464013054	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1195464013055	dimer interface [polypeptide binding]; other site
1195464013056	tetramer interface [polypeptide binding]; other site
1195464013057	PYR/PP interface [polypeptide binding]; other site
1195464013058	TPP binding site [chemical binding]; other site
1195464013059	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1195464013060	TPP-binding site; other site
1195464013061	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1195464013062	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1195464013063	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1195464013064	UbiA prenyltransferase family; Region: UbiA; pfam01040
1195464013065	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
1195464013066	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1195464013067	DNA-binding site [nucleotide binding]; DNA binding site
1195464013068	RNA-binding motif; other site
1195464013069	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1195464013070	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1195464013071	active site flap/lid [active]
1195464013072	nucleophilic elbow; other site
1195464013073	catalytic triad [active]
1195464013074	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464013075	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1195464013076	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1195464013077	homodimer interface [polypeptide binding]; other site
1195464013078	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1195464013079	active site pocket [active]
1195464013080	glycogen synthase; Provisional; Region: glgA; PRK00654
1195464013081	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1195464013082	ADP-binding pocket [chemical binding]; other site
1195464013083	homodimer interface [polypeptide binding]; other site
1195464013084	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1195464013085	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1195464013086	ligand binding site; other site
1195464013087	oligomer interface; other site
1195464013088	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1195464013089	dimer interface [polypeptide binding]; other site
1195464013090	N-terminal domain interface [polypeptide binding]; other site
1195464013091	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1195464013092	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1195464013093	ligand binding site; other site
1195464013094	oligomer interface; other site
1195464013095	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1195464013096	dimer interface [polypeptide binding]; other site
1195464013097	N-terminal domain interface [polypeptide binding]; other site
1195464013098	sulfate 1 binding site; other site
1195464013099	glycogen branching enzyme; Provisional; Region: PRK12313
1195464013100	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1195464013101	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1195464013102	active site
1195464013103	catalytic site [active]
1195464013104	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1195464013105	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1195464013106	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1195464013107	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1195464013108	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1195464013109	putative active site [active]
1195464013110	catalytic triad [active]
1195464013111	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1195464013112	PA/protease domain interface [polypeptide binding]; other site
1195464013113	putative integrin binding motif; other site
1195464013114	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1195464013115	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1195464013116	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1195464013117	dockerin binding interface; other site
1195464013118	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1195464013119	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1195464013120	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464013121	NAD binding site [chemical binding]; other site
1195464013122	dimer interface [polypeptide binding]; other site
1195464013123	substrate binding site [chemical binding]; other site
1195464013124	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
1195464013125	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
1195464013126	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1195464013127	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464013128	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464013129	DNA binding residues [nucleotide binding]
1195464013130	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1195464013131	MgtC family; Region: MgtC; pfam02308
1195464013132	Ion channel; Region: Ion_trans_2; pfam07885
1195464013133	TrkA-N domain; Region: TrkA_N; pfam02254
1195464013134	YugN-like family; Region: YugN; pfam08868
1195464013135	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1195464013136	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1195464013137	active site
1195464013138	dimer interface [polypeptide binding]; other site
1195464013139	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1195464013140	dimer interface [polypeptide binding]; other site
1195464013141	active site
1195464013142	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1195464013143	general stress protein 13; Validated; Region: PRK08059
1195464013144	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1195464013145	RNA binding site [nucleotide binding]; other site
1195464013146	hypothetical protein; Validated; Region: PRK07682
1195464013147	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464013148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464013149	homodimer interface [polypeptide binding]; other site
1195464013150	catalytic residue [active]
1195464013151	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1195464013152	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464013153	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1195464013154	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1195464013155	dimerization interface [polypeptide binding]; other site
1195464013156	ligand binding site [chemical binding]; other site
1195464013157	NADP binding site [chemical binding]; other site
1195464013158	catalytic site [active]
1195464013159	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1195464013160	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464013161	nucleophilic elbow; other site
1195464013162	catalytic triad; other site
1195464013163	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
1195464013164	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1195464013165	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464013166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464013167	homodimer interface [polypeptide binding]; other site
1195464013168	catalytic residue [active]
1195464013169	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1195464013170	E-class dimer interface [polypeptide binding]; other site
1195464013171	P-class dimer interface [polypeptide binding]; other site
1195464013172	active site
1195464013173	Cu2+ binding site [ion binding]; other site
1195464013174	Zn2+ binding site [ion binding]; other site
1195464013175	Kinase associated protein B; Region: KapB; pfam08810
1195464013176	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1195464013177	catalytic site [active]
1195464013178	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1195464013179	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1195464013180	transmembrane helices; other site
1195464013181	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1195464013182	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1195464013183	active site
1195464013184	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1195464013185	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1195464013186	motif 1; other site
1195464013187	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1195464013188	active site
1195464013189	motif 2; other site
1195464013190	motif 3; other site
1195464013191	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1195464013192	anticodon binding site; other site
1195464013193	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1195464013194	CoenzymeA binding site [chemical binding]; other site
1195464013195	subunit interaction site [polypeptide binding]; other site
1195464013196	PHB binding site; other site
1195464013197	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1195464013198	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1195464013199	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1195464013200	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1195464013201	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1195464013202	active site
1195464013203	tetramer interface; other site
1195464013204	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1195464013205	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1195464013206	active site
1195464013207	substrate binding site [chemical binding]; other site
1195464013208	metal binding site [ion binding]; metal-binding site
1195464013209	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
1195464013210	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1195464013211	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1195464013212	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1195464013213	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1195464013214	interface (dimer of trimers) [polypeptide binding]; other site
1195464013215	Substrate-binding/catalytic site; other site
1195464013216	Zn-binding sites [ion binding]; other site
1195464013217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464013218	Putative membrane protein; Region: YuiB; pfam14068
1195464013219	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1195464013220	nudix motif; other site
1195464013221	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1195464013222	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464013223	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1195464013224	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464013225	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464013226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1195464013227	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464013228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464013229	putative substrate translocation pore; other site
1195464013230	Helix-turn-helix domain; Region: HTH_36; pfam13730
1195464013231	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1195464013232	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1195464013233	putative DNA binding site [nucleotide binding]; other site
1195464013234	dimerization interface [polypeptide binding]; other site
1195464013235	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1195464013236	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464013237	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1195464013238	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464013239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464013240	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1195464013241	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1195464013242	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1195464013243	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1195464013244	hypothetical protein; Provisional; Region: PRK13669
1195464013245	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1195464013246	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464013247	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464013248	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464013249	Walker A/P-loop; other site
1195464013250	ATP binding site [chemical binding]; other site
1195464013251	Q-loop/lid; other site
1195464013252	ABC transporter signature motif; other site
1195464013253	Walker B; other site
1195464013254	D-loop; other site
1195464013255	H-loop/switch region; other site
1195464013256	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1195464013257	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1195464013258	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1195464013259	PhnA protein; Region: PhnA; pfam03831
1195464013260	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
1195464013261	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1195464013262	active site
1195464013263	NTP binding site [chemical binding]; other site
1195464013264	metal binding triad [ion binding]; metal-binding site
1195464013265	antibiotic binding site [chemical binding]; other site
1195464013266	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1195464013267	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
1195464013268	NifU-like domain; Region: NifU; pfam01106
1195464013269	spore coat protein YutH; Region: spore_yutH; TIGR02905
1195464013270	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1195464013271	tetramer interfaces [polypeptide binding]; other site
1195464013272	binuclear metal-binding site [ion binding]; other site
1195464013273	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464013274	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1195464013275	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1195464013276	FtsX-like permease family; Region: FtsX; pfam02687
1195464013277	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1195464013278	FtsX-like permease family; Region: FtsX; pfam02687
1195464013279	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464013280	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464013281	Walker A/P-loop; other site
1195464013282	ATP binding site [chemical binding]; other site
1195464013283	Q-loop/lid; other site
1195464013284	ABC transporter signature motif; other site
1195464013285	Walker B; other site
1195464013286	D-loop; other site
1195464013287	H-loop/switch region; other site
1195464013288	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1195464013289	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464013290	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1195464013291	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464013292	active site
1195464013293	motif I; other site
1195464013294	motif II; other site
1195464013295	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464013296	Predicted transcriptional regulator [Transcription]; Region: COG2345
1195464013297	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464013298	putative Zn2+ binding site [ion binding]; other site
1195464013299	putative DNA binding site [nucleotide binding]; other site
1195464013300	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1195464013301	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1195464013302	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1195464013303	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1195464013304	putative active site [active]
1195464013305	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1195464013306	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
1195464013307	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464013308	RNA binding surface [nucleotide binding]; other site
1195464013309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464013310	Coenzyme A binding pocket [chemical binding]; other site
1195464013311	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1195464013312	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1195464013313	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464013314	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1195464013315	DNA binding residues [nucleotide binding]
1195464013316	dimer interface [polypeptide binding]; other site
1195464013317	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1195464013318	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1195464013319	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1195464013320	catalytic core [active]
1195464013321	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1195464013322	putative deacylase active site [active]
1195464013323	lipoyl synthase; Provisional; Region: PRK05481
1195464013324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464013325	FeS/SAM binding site; other site
1195464013326	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464013327	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464013328	sporulation protein YunB; Region: spo_yunB; TIGR02832
1195464013329	Uncharacterized conserved protein [Function unknown]; Region: COG3377
1195464013330	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1195464013331	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1195464013332	active site
1195464013333	metal binding site [ion binding]; metal-binding site
1195464013334	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1195464013335	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1195464013336	FeS assembly protein SufB; Region: sufB; TIGR01980
1195464013337	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1195464013338	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1195464013339	trimerization site [polypeptide binding]; other site
1195464013340	active site
1195464013341	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1195464013342	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1195464013343	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1195464013344	catalytic residue [active]
1195464013345	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1195464013346	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1195464013347	FeS assembly protein SufD; Region: sufD; TIGR01981
1195464013348	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1195464013349	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1195464013350	Walker A/P-loop; other site
1195464013351	ATP binding site [chemical binding]; other site
1195464013352	Q-loop/lid; other site
1195464013353	ABC transporter signature motif; other site
1195464013354	Walker B; other site
1195464013355	D-loop; other site
1195464013356	H-loop/switch region; other site
1195464013357	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1195464013358	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1195464013359	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1195464013360	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1195464013361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464013362	ABC-ATPase subunit interface; other site
1195464013363	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1195464013364	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1195464013365	Walker A/P-loop; other site
1195464013366	ATP binding site [chemical binding]; other site
1195464013367	Q-loop/lid; other site
1195464013368	ABC transporter signature motif; other site
1195464013369	Walker B; other site
1195464013370	D-loop; other site
1195464013371	H-loop/switch region; other site
1195464013372	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1195464013373	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464013374	catalytic residues [active]
1195464013375	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1195464013376	putative active site [active]
1195464013377	putative metal binding site [ion binding]; other site
1195464013378	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1195464013379	lipoyl attachment site [posttranslational modification]; other site
1195464013380	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1195464013381	ArsC family; Region: ArsC; pfam03960
1195464013382	putative ArsC-like catalytic residues; other site
1195464013383	putative TRX-like catalytic residues [active]
1195464013384	Protein of unknown function (DUF3937); Region: DUF3937; pfam13073
1195464013385	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1195464013386	active site
1195464013387	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1195464013388	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1195464013389	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1195464013390	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1195464013391	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464013392	NAD binding site [chemical binding]; other site
1195464013393	dimer interface [polypeptide binding]; other site
1195464013394	substrate binding site [chemical binding]; other site
1195464013395	Coat F domain; Region: Coat_F; pfam07875
1195464013396	CAAX protease self-immunity; Region: Abi; pfam02517
1195464013397	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1195464013398	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1195464013399	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1195464013400	active site
1195464013401	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1195464013402	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1195464013403	dimer interface [polypeptide binding]; other site
1195464013404	active site
1195464013405	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1195464013406	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1195464013407	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1195464013408	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1195464013409	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1195464013410	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1195464013411	substrate binding site [chemical binding]; other site
1195464013412	oxyanion hole (OAH) forming residues; other site
1195464013413	YuzL-like protein; Region: YuzL; pfam14115
1195464013414	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464013415	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1195464013416	Proline dehydrogenase; Region: Pro_dh; cl03282
1195464013417	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
1195464013418	Domain of unknown function DUF77; Region: DUF77; pfam01910
1195464013419	Cache domain; Region: Cache_1; pfam02743
1195464013420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464013421	dimerization interface [polypeptide binding]; other site
1195464013422	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464013423	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464013424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464013425	dimer interface [polypeptide binding]; other site
1195464013426	putative CheW interface [polypeptide binding]; other site
1195464013427	Predicted transcriptional regulators [Transcription]; Region: COG1378
1195464013428	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1195464013429	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1195464013430	C-terminal domain interface [polypeptide binding]; other site
1195464013431	sugar binding site [chemical binding]; other site
1195464013432	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464013433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464013434	putative substrate translocation pore; other site
1195464013435	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1195464013436	Spore germination protein; Region: Spore_permease; cl17796
1195464013437	OxaA-like protein precursor; Validated; Region: PRK01622
1195464013438	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464013439	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464013440	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464013441	hypothetical protein; Provisional; Region: PRK06758
1195464013442	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1195464013443	active site
1195464013444	putative substrate binding region [chemical binding]; other site
1195464013445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464013446	non-specific DNA binding site [nucleotide binding]; other site
1195464013447	salt bridge; other site
1195464013448	sequence-specific DNA binding site [nucleotide binding]; other site
1195464013449	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464013450	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464013451	Protein of unknown function (DUF3978); Region: DUF3978; pfam13123
1195464013452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1195464013453	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1195464013454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464013455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464013456	active site
1195464013457	phosphorylation site [posttranslational modification]
1195464013458	intermolecular recognition site; other site
1195464013459	dimerization interface [polypeptide binding]; other site
1195464013460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464013461	DNA binding site [nucleotide binding]
1195464013462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464013463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464013464	dimer interface [polypeptide binding]; other site
1195464013465	phosphorylation site [posttranslational modification]
1195464013466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464013467	ATP binding site [chemical binding]; other site
1195464013468	Mg2+ binding site [ion binding]; other site
1195464013469	G-X-G motif; other site
1195464013470	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464013471	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1195464013472	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1195464013473	active site
1195464013474	HIGH motif; other site
1195464013475	KMSKS motif; other site
1195464013476	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1195464013477	tRNA binding surface [nucleotide binding]; other site
1195464013478	anticodon binding site; other site
1195464013479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464013480	S-adenosylmethionine binding site [chemical binding]; other site
1195464013481	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1195464013482	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464013483	dimerization interface [polypeptide binding]; other site
1195464013484	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464013485	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464013486	dimer interface [polypeptide binding]; other site
1195464013487	putative CheW interface [polypeptide binding]; other site
1195464013488	CHASE3 domain; Region: CHASE3; cl05000
1195464013489	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1195464013490	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464013491	dimerization interface [polypeptide binding]; other site
1195464013492	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464013493	dimer interface [polypeptide binding]; other site
1195464013494	putative CheW interface [polypeptide binding]; other site
1195464013495	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1195464013496	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464013497	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464013498	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1195464013499	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1195464013500	active site
1195464013501	Zn binding site [ion binding]; other site
1195464013502	Pirin-related protein [General function prediction only]; Region: COG1741
1195464013503	Pirin; Region: Pirin; pfam02678
1195464013504	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464013505	MarR family; Region: MarR_2; pfam12802
1195464013506	Protein of unknown function (DUF3920); Region: DUF3920; pfam13058
1195464013507	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464013508	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464013509	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1195464013510	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1195464013511	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1195464013512	TrkA-C domain; Region: TrkA_C; pfam02080
1195464013513	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464013514	amino acid carrier protein; Region: agcS; TIGR00835
1195464013515	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1195464013516	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1195464013517	dimerization interface [polypeptide binding]; other site
1195464013518	DPS ferroxidase diiron center [ion binding]; other site
1195464013519	ion pore; other site
1195464013520	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1195464013521	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
1195464013522	metal binding site [ion binding]; metal-binding site
1195464013523	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1195464013524	Ferritin-like domain; Region: Ferritin; pfam00210
1195464013525	ferroxidase diiron center [ion binding]; other site
1195464013526	Predicted membrane protein [Function unknown]; Region: COG2311
1195464013527	Protein of unknown function (DUF418); Region: DUF418; cl12135
1195464013528	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1195464013529	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1195464013530	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1195464013531	Nucleoside recognition; Region: Gate; pfam07670
1195464013532	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464013533	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1195464013534	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1195464013535	Nucleoside recognition; Region: Gate; pfam07670
1195464013536	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464013537	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464013538	amino acid carrier protein; Region: agcS; TIGR00835
1195464013539	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464013540	amino acid carrier protein; Region: agcS; TIGR00835
1195464013541	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1195464013542	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1195464013543	NAD binding site [chemical binding]; other site
1195464013544	substrate binding site [chemical binding]; other site
1195464013545	putative active site [active]
1195464013546	TQXA domain; Region: TQXA_dom; TIGR03934
1195464013547	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464013548	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464013549	active site
1195464013550	catalytic tetrad [active]
1195464013551	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1195464013552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464013553	putative substrate translocation pore; other site
1195464013554	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464013555	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464013556	dimerization interface [polypeptide binding]; other site
1195464013557	putative DNA binding site [nucleotide binding]; other site
1195464013558	putative Zn2+ binding site [ion binding]; other site
1195464013559	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1195464013560	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1195464013561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464013562	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1195464013563	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1195464013564	active site
1195464013565	HIGH motif; other site
1195464013566	dimer interface [polypeptide binding]; other site
1195464013567	KMSKS motif; other site
1195464013568	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464013569	RNA binding surface [nucleotide binding]; other site
1195464013570	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436
1195464013571	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464013572	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1195464013573	SET domain; Region: SET; pfam00856
1195464013574	Domain of unknown function (DUF4077); Region: DUF4077; pfam13295
1195464013575	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464013576	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464013577	dimer interface [polypeptide binding]; other site
1195464013578	putative CheW interface [polypeptide binding]; other site
1195464013579	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1195464013580	putative phosphate binding site [ion binding]; other site
1195464013581	camphor resistance protein CrcB; Provisional; Region: PRK14219
1195464013582	camphor resistance protein CrcB; Provisional; Region: PRK14205
1195464013583	Protein of unknown function (DUF3947); Region: DUF3947; pfam13135
1195464013584	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
1195464013585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464013586	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464013587	putative substrate translocation pore; other site
1195464013588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464013589	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464013590	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464013591	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464013592	ABC transporter; Region: ABC_tran_2; pfam12848
1195464013593	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464013594	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1195464013595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464013596	Coenzyme A binding pocket [chemical binding]; other site
1195464013597	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1195464013598	Nuclease-related domain; Region: NERD; pfam08378
1195464013599	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1195464013600	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464013601	catalytic triad [active]
1195464013602	conserved cis-peptide bond; other site
1195464013603	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1195464013604	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464013605	putative DNA binding site [nucleotide binding]; other site
1195464013606	putative Zn2+ binding site [ion binding]; other site
1195464013607	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464013608	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1195464013609	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1195464013610	AsnC family; Region: AsnC_trans_reg; pfam01037
1195464013611	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1195464013612	active site clefts [active]
1195464013613	zinc binding site [ion binding]; other site
1195464013614	dimer interface [polypeptide binding]; other site
1195464013615	cyanate hydratase; Validated; Region: PRK02866
1195464013616	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1195464013617	oligomer interface [polypeptide binding]; other site
1195464013618	active site
1195464013619	putative uracil/xanthine transporter; Provisional; Region: PRK11412
1195464013620	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464013621	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1195464013622	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1195464013623	Walker A/P-loop; other site
1195464013624	ATP binding site [chemical binding]; other site
1195464013625	Q-loop/lid; other site
1195464013626	ABC transporter signature motif; other site
1195464013627	Walker B; other site
1195464013628	D-loop; other site
1195464013629	H-loop/switch region; other site
1195464013630	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464013631	ABC-ATPase subunit  interface; other site
1195464013632	dimer interface [polypeptide binding]; other site
1195464013633	putative PBP binding regions; other site
1195464013634	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464013635	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464013636	ABC-ATPase subunit  interface; other site
1195464013637	dimer interface [polypeptide binding]; other site
1195464013638	putative PBP binding regions; other site
1195464013639	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1195464013640	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1195464013641	putative ligand binding residues [chemical binding]; other site
1195464013642	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464013643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464013644	active site
1195464013645	phosphorylation site [posttranslational modification]
1195464013646	intermolecular recognition site; other site
1195464013647	dimerization interface [polypeptide binding]; other site
1195464013648	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464013649	DNA binding site [nucleotide binding]
1195464013650	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1195464013651	SmpB-tmRNA interface; other site
1195464013652	ribonuclease R; Region: RNase_R; TIGR02063
1195464013653	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1195464013654	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1195464013655	RNB domain; Region: RNB; pfam00773
1195464013656	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1195464013657	RNA binding site [nucleotide binding]; other site
1195464013658	Esterase/lipase [General function prediction only]; Region: COG1647
1195464013659	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1195464013660	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1195464013661	holin-like protein; Validated; Region: PRK01658
1195464013662	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
1195464013663	active site
1195464013664	enolase; Provisional; Region: eno; PRK00077
1195464013665	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1195464013666	dimer interface [polypeptide binding]; other site
1195464013667	metal binding site [ion binding]; metal-binding site
1195464013668	substrate binding pocket [chemical binding]; other site
1195464013669	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1195464013670	phosphoglyceromutase; Provisional; Region: PRK05434
1195464013671	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1195464013672	triosephosphate isomerase; Provisional; Region: PRK14565
1195464013673	substrate binding site [chemical binding]; other site
1195464013674	dimer interface [polypeptide binding]; other site
1195464013675	catalytic triad [active]
1195464013676	Phosphoglycerate kinase; Region: PGK; pfam00162
1195464013677	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1195464013678	substrate binding site [chemical binding]; other site
1195464013679	hinge regions; other site
1195464013680	ADP binding site [chemical binding]; other site
1195464013681	catalytic site [active]
1195464013682	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1195464013683	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1195464013684	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1195464013685	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1195464013686	Predicted transcriptional regulator [Transcription]; Region: COG3388
1195464013687	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1195464013688	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1195464013689	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1195464013690	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1195464013691	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1195464013692	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1195464013693	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1195464013694	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1195464013695	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
1195464013696	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1195464013697	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1195464013698	stage V sporulation protein AD; Provisional; Region: PRK12404
1195464013699	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
1195464013700	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
1195464013701	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
1195464013702	Predicted membrane protein [Function unknown]; Region: COG2323
1195464013703	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
1195464013704	Clp protease; Region: CLP_protease; pfam00574
1195464013705	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1195464013706	oligomer interface [polypeptide binding]; other site
1195464013707	active site residues [active]
1195464013708	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1195464013709	dimerization domain swap beta strand [polypeptide binding]; other site
1195464013710	regulatory protein interface [polypeptide binding]; other site
1195464013711	active site
1195464013712	regulatory phosphorylation site [posttranslational modification]; other site
1195464013713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1195464013714	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1195464013715	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1195464013716	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1195464013717	phosphate binding site [ion binding]; other site
1195464013718	putative substrate binding pocket [chemical binding]; other site
1195464013719	dimer interface [polypeptide binding]; other site
1195464013720	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1195464013721	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1195464013722	putative active site [active]
1195464013723	nucleotide binding site [chemical binding]; other site
1195464013724	nudix motif; other site
1195464013725	putative metal binding site [ion binding]; other site
1195464013726	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1195464013727	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1195464013728	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464013729	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464013730	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464013731	binding surface
1195464013732	TPR motif; other site
1195464013733	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464013734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464013735	binding surface
1195464013736	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1195464013737	TPR motif; other site
1195464013738	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1195464013739	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1195464013740	trimer interface [polypeptide binding]; other site
1195464013741	active site
1195464013742	substrate binding site [chemical binding]; other site
1195464013743	CoA binding site [chemical binding]; other site
1195464013744	pyrophosphatase PpaX; Provisional; Region: PRK13288
1195464013745	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464013746	active site
1195464013747	motif I; other site
1195464013748	motif II; other site
1195464013749	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1195464013750	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1195464013751	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1195464013752	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1195464013753	Hpr binding site; other site
1195464013754	active site
1195464013755	homohexamer subunit interaction site [polypeptide binding]; other site
1195464013756	Predicted membrane protein [Function unknown]; Region: COG1950
1195464013757	Domain of unknown function (DUF4275); Region: DUF4275; pfam14101
1195464013758	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1195464013759	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1195464013760	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1195464013761	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1195464013762	excinuclease ABC subunit B; Provisional; Region: PRK05298
1195464013763	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464013764	ATP binding site [chemical binding]; other site
1195464013765	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464013766	nucleotide binding region [chemical binding]; other site
1195464013767	ATP-binding site [chemical binding]; other site
1195464013768	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1195464013769	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1195464013770	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464013771	DNA binding residues [nucleotide binding]
1195464013772	dimer interface [polypeptide binding]; other site
1195464013773	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1195464013774	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464013775	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464013776	non-specific DNA binding site [nucleotide binding]; other site
1195464013777	salt bridge; other site
1195464013778	sequence-specific DNA binding site [nucleotide binding]; other site
1195464013779	Predicted membrane protein [Function unknown]; Region: COG2855
1195464013780	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464013781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464013782	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1195464013783	putative dimerization interface [polypeptide binding]; other site
1195464013784	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1195464013785	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1195464013786	DNA binding residues [nucleotide binding]
1195464013787	putative dimer interface [polypeptide binding]; other site
1195464013788	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1195464013789	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1195464013790	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464013791	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464013792	ABC transporter; Region: ABC_tran_2; pfam12848
1195464013793	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464013794	hypothetical protein; Provisional; Region: PRK12855
1195464013795	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464013796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464013797	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1195464013798	Walker A/P-loop; other site
1195464013799	ATP binding site [chemical binding]; other site
1195464013800	Q-loop/lid; other site
1195464013801	ABC transporter signature motif; other site
1195464013802	Walker B; other site
1195464013803	D-loop; other site
1195464013804	H-loop/switch region; other site
1195464013805	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1195464013806	protein binding site [polypeptide binding]; other site
1195464013807	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1195464013808	C-terminal peptidase (prc); Region: prc; TIGR00225
1195464013809	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1195464013810	protein binding site [polypeptide binding]; other site
1195464013811	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1195464013812	Catalytic dyad [active]
1195464013813	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1195464013814	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1195464013815	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1195464013816	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1195464013817	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464013818	Walker A/P-loop; other site
1195464013819	ATP binding site [chemical binding]; other site
1195464013820	Q-loop/lid; other site
1195464013821	ABC transporter signature motif; other site
1195464013822	Walker B; other site
1195464013823	D-loop; other site
1195464013824	H-loop/switch region; other site
1195464013825	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1195464013826	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1195464013827	peptide chain release factor 2; Provisional; Region: PRK06746
1195464013828	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1195464013829	RF-1 domain; Region: RF-1; pfam00472
1195464013830	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1195464013831	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1195464013832	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1195464013833	nucleotide binding region [chemical binding]; other site
1195464013834	ATP-binding site [chemical binding]; other site
1195464013835	SEC-C motif; Region: SEC-C; pfam02810
1195464013836	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1195464013837	30S subunit binding site; other site
1195464013838	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1195464013839	DNA-binding site [nucleotide binding]; DNA binding site
1195464013840	RNA-binding motif; other site
1195464013841	comF family protein; Region: comF; TIGR00201
1195464013842	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464013843	active site
1195464013844	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464013845	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
1195464013846	ATP binding site [chemical binding]; other site
1195464013847	putative Mg++ binding site [ion binding]; other site
1195464013848	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464013849	nucleotide binding region [chemical binding]; other site
1195464013850	ATP-binding site [chemical binding]; other site
1195464013851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1195464013852	Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304
1195464013853	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464013854	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464013855	Predicted transcriptional regulators [Transcription]; Region: COG1733
1195464013856	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1195464013857	EDD domain protein, DegV family; Region: DegV; TIGR00762
1195464013858	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1195464013859	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
1195464013860	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1195464013861	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1195464013862	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1195464013863	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1195464013864	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1195464013865	active site
1195464013866	homodimer interface [polypeptide binding]; other site
1195464013867	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1195464013868	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1195464013869	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1195464013870	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1195464013871	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1195464013872	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1195464013873	Mg++ binding site [ion binding]; other site
1195464013874	putative catalytic motif [active]
1195464013875	substrate binding site [chemical binding]; other site
1195464013876	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464013877	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1195464013878	NodB motif; other site
1195464013879	active site
1195464013880	catalytic site [active]
1195464013881	Zn binding site [ion binding]; other site
1195464013882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464013883	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1195464013884	Walker A motif; other site
1195464013885	ATP binding site [chemical binding]; other site
1195464013886	Walker B motif; other site
1195464013887	arginine finger; other site
1195464013888	Transcriptional antiterminator [Transcription]; Region: COG3933
1195464013889	PRD domain; Region: PRD; pfam00874
1195464013890	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1195464013891	active pocket/dimerization site; other site
1195464013892	active site
1195464013893	phosphorylation site [posttranslational modification]
1195464013894	PRD domain; Region: PRD; pfam00874
1195464013895	CHRD domain; Region: CHRD; pfam07452
1195464013896	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1195464013897	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1195464013898	Chromate transporter; Region: Chromate_transp; pfam02417
1195464013899	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
1195464013900	putative active site [active]
1195464013901	YdjC motif; other site
1195464013902	Mg binding site [ion binding]; other site
1195464013903	putative homodimer interface [polypeptide binding]; other site
1195464013904	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1195464013905	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1195464013906	NAD binding site [chemical binding]; other site
1195464013907	sugar binding site [chemical binding]; other site
1195464013908	divalent metal binding site [ion binding]; other site
1195464013909	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464013910	dimer interface [polypeptide binding]; other site
1195464013911	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1195464013912	active site
1195464013913	methionine cluster; other site
1195464013914	phosphorylation site [posttranslational modification]
1195464013915	metal binding site [ion binding]; metal-binding site
1195464013916	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1195464013917	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1195464013918	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1195464013919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464013920	S-adenosylmethionine binding site [chemical binding]; other site
1195464013921	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706
1195464013922	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1195464013923	methionine cluster; other site
1195464013924	active site
1195464013925	phosphorylation site [posttranslational modification]
1195464013926	metal binding site [ion binding]; metal-binding site
1195464013927	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1195464013928	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1195464013929	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1195464013930	active site
1195464013931	P-loop; other site
1195464013932	phosphorylation site [posttranslational modification]
1195464013933	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1195464013934	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1195464013935	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1195464013936	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1195464013937	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464013938	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1195464013939	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1195464013940	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
1195464013941	Predicted membrane protein [Function unknown]; Region: COG1511
1195464013942	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1195464013943	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1195464013944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464013945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464013946	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1195464013947	putative dimerization interface [polypeptide binding]; other site
1195464013948	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1195464013949	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1195464013950	arsenical pump membrane protein; Provisional; Region: PRK15445
1195464013951	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1195464013952	transmembrane helices; other site
1195464013953	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1195464013954	ThiC-associated domain; Region: ThiC-associated; pfam13667
1195464013955	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1195464013956	L-lactate permease; Region: Lactate_perm; cl00701
1195464013957	glycolate transporter; Provisional; Region: PRK09695
1195464013958	Tic20-like protein; Region: Tic20; pfam09685
1195464013959	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
1195464013960	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
1195464013961	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1195464013962	Sulfatase; Region: Sulfatase; pfam00884
1195464013963	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1195464013964	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1195464013965	homodimer interface [polypeptide binding]; other site
1195464013966	substrate-cofactor binding pocket; other site
1195464013967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464013968	catalytic residue [active]
1195464013969	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013970	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013971	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013972	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013973	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013974	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1195464013975	NlpC/P60 family; Region: NLPC_P60; pfam00877
1195464013976	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1195464013977	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1195464013978	Nucleoside recognition; Region: Gate; pfam07670
1195464013979	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464013980	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1195464013981	metal binding site [ion binding]; metal-binding site
1195464013982	nucleotidyl binding site; other site
1195464013983	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1195464013984	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1195464013985	DXD motif; other site
1195464013986	BCCT family transporter; Region: BCCT; pfam02028
1195464013987	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013988	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464013989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464013990	Protein of unknown function (DUF3910); Region: DUF3910; pfam13049
1195464013991	SNF2 Helicase protein; Region: DUF3670; pfam12419
1195464013992	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1195464013993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464013994	ATP binding site [chemical binding]; other site
1195464013995	putative Mg++ binding site [ion binding]; other site
1195464013996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464013997	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1195464013998	nucleotide binding region [chemical binding]; other site
1195464013999	ATP-binding site [chemical binding]; other site
1195464014000	Predicted integral membrane protein [Function unknown]; Region: COG5652
1195464014001	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
1195464014002	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1195464014003	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
1195464014004	ComK protein; Region: ComK; cl11560
1195464014005	RNA polymerase factor sigma-70; Validated; Region: PRK06759
1195464014006	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464014007	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464014008	DNA binding residues [nucleotide binding]
1195464014009	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
1195464014010	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1195464014011	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1195464014012	FtsX-like permease family; Region: FtsX; pfam02687
1195464014013	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1195464014014	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1195464014015	Walker A/P-loop; other site
1195464014016	ATP binding site [chemical binding]; other site
1195464014017	Q-loop/lid; other site
1195464014018	ABC transporter signature motif; other site
1195464014019	Walker B; other site
1195464014020	D-loop; other site
1195464014021	H-loop/switch region; other site
1195464014022	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1195464014023	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1195464014024	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1195464014025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464014026	putative substrate translocation pore; other site
1195464014027	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1195464014028	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1195464014029	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
1195464014030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464014031	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464014032	dimerization interface [polypeptide binding]; other site
1195464014033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464014034	dimer interface [polypeptide binding]; other site
1195464014035	phosphorylation site [posttranslational modification]
1195464014036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464014037	ATP binding site [chemical binding]; other site
1195464014038	Mg2+ binding site [ion binding]; other site
1195464014039	G-X-G motif; other site
1195464014040	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464014041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014042	active site
1195464014043	phosphorylation site [posttranslational modification]
1195464014044	intermolecular recognition site; other site
1195464014045	dimerization interface [polypeptide binding]; other site
1195464014046	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464014047	DNA binding site [nucleotide binding]
1195464014048	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1195464014049	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1195464014050	NAD binding site [chemical binding]; other site
1195464014051	homodimer interface [polypeptide binding]; other site
1195464014052	active site
1195464014053	substrate binding site [chemical binding]; other site
1195464014054	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1195464014055	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
1195464014056	active site
1195464014057	metal-binding site
1195464014058	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464014059	EamA-like transporter family; Region: EamA; cl17759
1195464014060	EamA-like transporter family; Region: EamA; cl17759
1195464014061	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464014062	putative DNA binding site [nucleotide binding]; other site
1195464014063	putative Zn2+ binding site [ion binding]; other site
1195464014064	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464014065	active site
1195464014066	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
1195464014067	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464014068	active site
1195464014069	substrate binding site [chemical binding]; other site
1195464014070	ATP binding site [chemical binding]; other site
1195464014071	dimer interface [polypeptide binding]; other site
1195464014072	LicD family; Region: LicD; pfam04991
1195464014073	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1195464014074	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
1195464014075	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1195464014076	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1195464014077	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1195464014078	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1195464014079	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464014080	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1195464014081	putative ADP-binding pocket [chemical binding]; other site
1195464014082	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1195464014083	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464014084	active site
1195464014085	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1195464014086	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464014087	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1195464014088	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1195464014089	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1195464014090	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1195464014091	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1195464014092	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1195464014093	active site
1195464014094	tetramer interface; other site
1195464014095	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1195464014096	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1195464014097	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1195464014098	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1195464014099	Chain length determinant protein; Region: Wzz; cl15801
1195464014100	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1195464014101	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1195464014102	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1195464014103	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1195464014104	MreB and similar proteins; Region: MreB_like; cd10225
1195464014105	nucleotide binding site [chemical binding]; other site
1195464014106	Mg binding site [ion binding]; other site
1195464014107	putative protofilament interaction site [polypeptide binding]; other site
1195464014108	RodZ interaction site [polypeptide binding]; other site
1195464014109	Stage III sporulation protein D; Region: SpoIIID; cl17560
1195464014110	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1195464014111	Peptidase family M23; Region: Peptidase_M23; pfam01551
1195464014112	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1195464014113	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1195464014114	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464014115	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464014116	Walker A/P-loop; other site
1195464014117	ATP binding site [chemical binding]; other site
1195464014118	Q-loop/lid; other site
1195464014119	ABC transporter signature motif; other site
1195464014120	Walker B; other site
1195464014121	D-loop; other site
1195464014122	H-loop/switch region; other site
1195464014123	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1195464014124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464014125	Walker A/P-loop; other site
1195464014126	ATP binding site [chemical binding]; other site
1195464014127	Q-loop/lid; other site
1195464014128	ABC transporter signature motif; other site
1195464014129	Walker B; other site
1195464014130	D-loop; other site
1195464014131	H-loop/switch region; other site
1195464014132	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1195464014133	LytTr DNA-binding domain; Region: LytTR; pfam04397
1195464014134	Stage II sporulation protein; Region: SpoIID; pfam08486
1195464014135	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1195464014136	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1195464014137	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1195464014138	hinge; other site
1195464014139	active site
1195464014140	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
1195464014141	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1195464014142	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1195464014143	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1195464014144	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1195464014145	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1195464014146	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1195464014147	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1195464014148	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1195464014149	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1195464014150	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1195464014151	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1195464014152	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1195464014153	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1195464014154	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1195464014155	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1195464014156	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
1195464014157	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1195464014158	NADH dehydrogenase subunit C; Validated; Region: PRK07735
1195464014159	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1195464014160	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1195464014161	NADH dehydrogenase subunit A; Validated; Region: PRK07756
1195464014162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464014163	PAS domain; Region: PAS_9; pfam13426
1195464014164	putative active site [active]
1195464014165	heme pocket [chemical binding]; other site
1195464014166	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464014167	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464014168	metal binding site [ion binding]; metal-binding site
1195464014169	active site
1195464014170	I-site; other site
1195464014171	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464014172	Protein of unknown function (DUF975); Region: DUF975; cl10504
1195464014173	Protein of unknown function (DUF975); Region: DUF975; cl10504
1195464014174	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1195464014175	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1195464014176	gamma subunit interface [polypeptide binding]; other site
1195464014177	epsilon subunit interface [polypeptide binding]; other site
1195464014178	LBP interface [polypeptide binding]; other site
1195464014179	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1195464014180	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1195464014181	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1195464014182	alpha subunit interaction interface [polypeptide binding]; other site
1195464014183	Walker A motif; other site
1195464014184	ATP binding site [chemical binding]; other site
1195464014185	Walker B motif; other site
1195464014186	inhibitor binding site; inhibition site
1195464014187	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1195464014188	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1195464014189	core domain interface [polypeptide binding]; other site
1195464014190	delta subunit interface [polypeptide binding]; other site
1195464014191	epsilon subunit interface [polypeptide binding]; other site
1195464014192	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1195464014193	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1195464014194	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1195464014195	beta subunit interaction interface [polypeptide binding]; other site
1195464014196	Walker A motif; other site
1195464014197	ATP binding site [chemical binding]; other site
1195464014198	Walker B motif; other site
1195464014199	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1195464014200	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1195464014201	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1195464014202	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1195464014203	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1195464014204	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1195464014205	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1195464014206	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1195464014207	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1195464014208	Protein of unknown function (DUF4024); Region: DUF4024; pfam13216
1195464014209	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464014210	active site
1195464014211	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1195464014212	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1195464014213	dimer interface [polypeptide binding]; other site
1195464014214	active site
1195464014215	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1195464014216	folate binding site [chemical binding]; other site
1195464014217	hypothetical protein; Provisional; Region: PRK13690
1195464014218	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1195464014219	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1195464014220	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1195464014221	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1195464014222	HPr interaction site; other site
1195464014223	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1195464014224	active site
1195464014225	phosphorylation site [posttranslational modification]
1195464014226	Predicted membrane protein [Function unknown]; Region: COG2259
1195464014227	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1195464014228	Protein of unknown function (DUF3935); Region: DUF3935; pfam13071
1195464014229	Predicted membrane protein [Function unknown]; Region: COG1971
1195464014230	Domain of unknown function DUF; Region: DUF204; pfam02659
1195464014231	Domain of unknown function DUF; Region: DUF204; pfam02659
1195464014232	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1195464014233	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1195464014234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1195464014235	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
1195464014236	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1195464014237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464014238	S-adenosylmethionine binding site [chemical binding]; other site
1195464014239	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1195464014240	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1195464014241	RF-1 domain; Region: RF-1; pfam00472
1195464014242	thymidine kinase; Provisional; Region: PRK04296
1195464014243	LabA_like proteins; Region: LabA_like/DUF88; cl10034
1195464014244	putative metal binding site [ion binding]; other site
1195464014245	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1195464014246	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1195464014247	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1195464014248	RNA binding site [nucleotide binding]; other site
1195464014249	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1195464014250	multimer interface [polypeptide binding]; other site
1195464014251	Walker A motif; other site
1195464014252	ATP binding site [chemical binding]; other site
1195464014253	Walker B motif; other site
1195464014254	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1195464014255	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1195464014256	putative active site [active]
1195464014257	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1195464014258	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1195464014259	hinge; other site
1195464014260	active site
1195464014261	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1195464014262	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1195464014263	intersubunit interface [polypeptide binding]; other site
1195464014264	active site
1195464014265	zinc binding site [ion binding]; other site
1195464014266	Na+ binding site [ion binding]; other site
1195464014267	Response regulator receiver domain; Region: Response_reg; pfam00072
1195464014268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014269	active site
1195464014270	phosphorylation site [posttranslational modification]
1195464014271	intermolecular recognition site; other site
1195464014272	dimerization interface [polypeptide binding]; other site
1195464014273	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
1195464014274	CTP synthetase; Validated; Region: pyrG; PRK05380
1195464014275	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1195464014276	Catalytic site [active]
1195464014277	active site
1195464014278	UTP binding site [chemical binding]; other site
1195464014279	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1195464014280	active site
1195464014281	putative oxyanion hole; other site
1195464014282	catalytic triad [active]
1195464014283	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1195464014284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464014285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464014286	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1195464014287	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1195464014288	FAD binding site [chemical binding]; other site
1195464014289	homotetramer interface [polypeptide binding]; other site
1195464014290	substrate binding pocket [chemical binding]; other site
1195464014291	catalytic base [active]
1195464014292	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1195464014293	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1195464014294	FAD binding site [chemical binding]; other site
1195464014295	homotetramer interface [polypeptide binding]; other site
1195464014296	substrate binding pocket [chemical binding]; other site
1195464014297	catalytic base [active]
1195464014298	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1195464014299	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1195464014300	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1195464014301	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
1195464014302	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1195464014303	dimer interface [polypeptide binding]; other site
1195464014304	active site
1195464014305	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1195464014306	4Fe-4S binding domain; Region: Fer4; cl02805
1195464014307	Cysteine-rich domain; Region: CCG; pfam02754
1195464014308	Cysteine-rich domain; Region: CCG; pfam02754
1195464014309	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1195464014310	PLD-like domain; Region: PLDc_2; pfam13091
1195464014311	putative active site [active]
1195464014312	catalytic site [active]
1195464014313	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1195464014314	PLD-like domain; Region: PLDc_2; pfam13091
1195464014315	putative active site [active]
1195464014316	catalytic site [active]
1195464014317	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1195464014318	Domain of unknown function (DUF4084); Region: DUF4084; pfam13321
1195464014319	PAS domain S-box; Region: sensory_box; TIGR00229
1195464014320	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464014321	putative active site [active]
1195464014322	heme pocket [chemical binding]; other site
1195464014323	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464014324	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464014325	metal binding site [ion binding]; metal-binding site
1195464014326	active site
1195464014327	I-site; other site
1195464014328	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464014329	Bacillus PapR protein; Region: Bacillus_PapR; pfam05968
1195464014330	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464014331	non-specific DNA binding site [nucleotide binding]; other site
1195464014332	salt bridge; other site
1195464014333	sequence-specific DNA binding site [nucleotide binding]; other site
1195464014334	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464014335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464014336	TPR motif; other site
1195464014337	binding surface
1195464014338	TPR repeat; Region: TPR_11; pfam13414
1195464014339	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464014340	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464014341	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1195464014342	active site
1195464014343	Zn binding site [ion binding]; other site
1195464014344	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464014345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014346	active site
1195464014347	phosphorylation site [posttranslational modification]
1195464014348	intermolecular recognition site; other site
1195464014349	dimerization interface [polypeptide binding]; other site
1195464014350	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464014351	DNA binding residues [nucleotide binding]
1195464014352	dimerization interface [polypeptide binding]; other site
1195464014353	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1195464014354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464014355	Histidine kinase; Region: HisKA_3; pfam07730
1195464014356	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1195464014357	Mg2+ binding site [ion binding]; other site
1195464014358	G-X-G motif; other site
1195464014359	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1195464014360	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1195464014361	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464014362	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1195464014363	Walker A/P-loop; other site
1195464014364	ATP binding site [chemical binding]; other site
1195464014365	Q-loop/lid; other site
1195464014366	ABC transporter signature motif; other site
1195464014367	Walker B; other site
1195464014368	D-loop; other site
1195464014369	H-loop/switch region; other site
1195464014370	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1195464014371	active site
1195464014372	Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326
1195464014373	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1195464014374	Collagen binding domain; Region: Collagen_bind; pfam05737
1195464014375	Collagen binding domain; Region: Collagen_bind; pfam05737
1195464014376	Collagen binding domain; Region: Collagen_bind; pfam05737
1195464014377	Collagen binding domain; Region: Collagen_bind; pfam05737
1195464014378	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014379	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014380	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014381	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014382	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014383	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014384	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014385	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1195464014386	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014387	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014388	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014389	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014390	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014391	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014392	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014393	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1195464014394	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014395	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014396	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014397	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014398	Cna protein B-type domain; Region: Cna_B; pfam05738
1195464014399	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1195464014400	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
1195464014401	PA/protease or protease-like domain interface [polypeptide binding]; other site
1195464014402	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1195464014403	Peptidase family M28; Region: Peptidase_M28; pfam04389
1195464014404	metal binding site [ion binding]; metal-binding site
1195464014405	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
1195464014406	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1195464014407	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1195464014408	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1195464014409	active site
1195464014410	HIGH motif; other site
1195464014411	KMSK motif region; other site
1195464014412	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1195464014413	tRNA binding surface [nucleotide binding]; other site
1195464014414	anticodon binding site; other site
1195464014415	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1195464014416	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1195464014417	putative dimer interface [polypeptide binding]; other site
1195464014418	catalytic triad [active]
1195464014419	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464014420	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1195464014421	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1195464014422	agmatinase; Region: agmatinase; TIGR01230
1195464014423	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1195464014424	putative active site [active]
1195464014425	Mn binding site [ion binding]; other site
1195464014426	spermidine synthase; Provisional; Region: PRK00811
1195464014427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464014428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464014429	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464014430	putative substrate translocation pore; other site
1195464014431	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1195464014432	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
1195464014433	DNA binding residues [nucleotide binding]
1195464014434	putative dimer interface [polypeptide binding]; other site
1195464014435	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1195464014436	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1195464014437	active site
1195464014438	catalytic site [active]
1195464014439	metal binding site [ion binding]; metal-binding site
1195464014440	dimer interface [polypeptide binding]; other site
1195464014441	Transglycosylase; Region: Transgly; pfam00912
1195464014442	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1195464014443	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1195464014444	YwhD family; Region: YwhD; pfam08741
1195464014445	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1195464014446	Peptidase family M50; Region: Peptidase_M50; pfam02163
1195464014447	active site
1195464014448	putative substrate binding region [chemical binding]; other site
1195464014449	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
1195464014450	active site 1 [active]
1195464014451	dimer interface [polypeptide binding]; other site
1195464014452	hexamer interface [polypeptide binding]; other site
1195464014453	active site 2 [active]
1195464014454	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1195464014455	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1195464014456	Zn2+ binding site [ion binding]; other site
1195464014457	Mg2+ binding site [ion binding]; other site
1195464014458	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464014459	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1195464014460	intersubunit interface [polypeptide binding]; other site
1195464014461	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1195464014462	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1195464014463	Walker A/P-loop; other site
1195464014464	ATP binding site [chemical binding]; other site
1195464014465	Q-loop/lid; other site
1195464014466	ABC transporter signature motif; other site
1195464014467	Walker B; other site
1195464014468	D-loop; other site
1195464014469	H-loop/switch region; other site
1195464014470	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1195464014471	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464014472	ABC-ATPase subunit  interface; other site
1195464014473	dimer interface [polypeptide binding]; other site
1195464014474	putative PBP binding regions; other site
1195464014475	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1195464014476	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464014477	ABC-ATPase subunit  interface; other site
1195464014478	dimer interface [polypeptide binding]; other site
1195464014479	putative PBP binding regions; other site
1195464014480	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1195464014481	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1195464014482	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1195464014483	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1195464014484	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1195464014485	putative heme peroxidase; Provisional; Region: PRK12276
1195464014486	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1195464014487	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464014488	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1195464014489	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1195464014490	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1195464014491	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
1195464014492	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1195464014493	Ion channel; Region: Ion_trans_2; pfam07885
1195464014494	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1195464014495	TrkA-N domain; Region: TrkA_N; pfam02254
1195464014496	TrkA-C domain; Region: TrkA_C; pfam02080
1195464014497	putative uracil/xanthine transporter; Provisional; Region: PRK11412
1195464014498	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464014499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464014500	motif II; other site
1195464014501	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464014502	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1195464014503	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1195464014504	ligand binding site [chemical binding]; other site
1195464014505	active site
1195464014506	UGI interface [polypeptide binding]; other site
1195464014507	catalytic site [active]
1195464014508	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1195464014509	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1195464014510	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1195464014511	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1195464014512	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1195464014513	Walker A/P-loop; other site
1195464014514	ATP binding site [chemical binding]; other site
1195464014515	Q-loop/lid; other site
1195464014516	ABC transporter signature motif; other site
1195464014517	Walker B; other site
1195464014518	D-loop; other site
1195464014519	H-loop/switch region; other site
1195464014520	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1195464014521	active site
1195464014522	catalytic triad [active]
1195464014523	oxyanion hole [active]
1195464014524	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464014525	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464014526	DNA binding site [nucleotide binding]
1195464014527	domain linker motif; other site
1195464014528	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1195464014529	putative dimerization interface [polypeptide binding]; other site
1195464014530	putative ligand binding site [chemical binding]; other site
1195464014531	Predicted membrane protein [Function unknown]; Region: COG2364
1195464014532	homoserine dehydrogenase; Provisional; Region: PRK06349
1195464014533	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1195464014534	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1195464014535	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1195464014536	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1195464014537	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1195464014538	proposed active site lysine [active]
1195464014539	conserved cys residue [active]
1195464014540	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702
1195464014541	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1195464014542	homodimer interface [polypeptide binding]; other site
1195464014543	substrate-cofactor binding pocket; other site
1195464014544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464014545	catalytic residue [active]
1195464014546	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1195464014547	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1195464014548	Cl- selectivity filter; other site
1195464014549	Cl- binding residues [ion binding]; other site
1195464014550	pore gating glutamate residue; other site
1195464014551	dimer interface [polypeptide binding]; other site
1195464014552	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1195464014553	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464014554	active site
1195464014555	motif I; other site
1195464014556	motif II; other site
1195464014557	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1195464014558	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464014559	ligand binding site [chemical binding]; other site
1195464014560	flexible hinge region; other site
1195464014561	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1195464014562	azoreductase; Provisional; Region: PRK13556
1195464014563	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464014564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014565	active site
1195464014566	phosphorylation site [posttranslational modification]
1195464014567	intermolecular recognition site; other site
1195464014568	dimerization interface [polypeptide binding]; other site
1195464014569	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464014570	DNA binding residues [nucleotide binding]
1195464014571	dimerization interface [polypeptide binding]; other site
1195464014572	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1195464014573	GAF domain; Region: GAF; pfam01590
1195464014574	GAF domain; Region: GAF_3; pfam13492
1195464014575	GAF domain; Region: GAF_2; pfam13185
1195464014576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464014577	Histidine kinase; Region: HisKA_3; pfam07730
1195464014578	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1195464014579	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1195464014580	dimer interface [polypeptide binding]; other site
1195464014581	substrate binding site [chemical binding]; other site
1195464014582	ATP binding site [chemical binding]; other site
1195464014583	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1195464014584	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464014585	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464014586	metal binding site [ion binding]; metal-binding site
1195464014587	active site
1195464014588	I-site; other site
1195464014589	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1195464014590	carbon starvation protein A; Provisional; Region: PRK15015
1195464014591	Carbon starvation protein CstA; Region: CstA; pfam02554
1195464014592	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1195464014593	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1195464014594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014595	active site
1195464014596	phosphorylation site [posttranslational modification]
1195464014597	intermolecular recognition site; other site
1195464014598	dimerization interface [polypeptide binding]; other site
1195464014599	LytTr DNA-binding domain; Region: LytTR; pfam04397
1195464014600	benzoate transport; Region: 2A0115; TIGR00895
1195464014601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464014602	putative substrate translocation pore; other site
1195464014603	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1195464014604	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1195464014605	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464014606	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1195464014607	Predicted membrane protein [Function unknown]; Region: COG2860
1195464014608	UPF0126 domain; Region: UPF0126; pfam03458
1195464014609	UPF0126 domain; Region: UPF0126; pfam03458
1195464014610	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1195464014611	heme-binding site [chemical binding]; other site
1195464014612	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464014613	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464014614	dimer interface [polypeptide binding]; other site
1195464014615	putative CheW interface [polypeptide binding]; other site
1195464014616	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1195464014617	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1195464014618	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1195464014619	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1195464014620	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1195464014621	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1195464014622	active site
1195464014623	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464014624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464014625	NAD(P) binding site [chemical binding]; other site
1195464014626	active site
1195464014627	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464014628	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464014629	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464014630	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464014631	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464014632	ABC transporter; Region: ABC_tran_2; pfam12848
1195464014633	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464014634	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1195464014635	Predicted membrane protein [Function unknown]; Region: COG2246
1195464014636	GtrA-like protein; Region: GtrA; pfam04138
1195464014637	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1195464014638	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1195464014639	Ligand binding site; other site
1195464014640	Putative Catalytic site; other site
1195464014641	DXD motif; other site
1195464014642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464014643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464014644	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1195464014645	Protein export membrane protein; Region: SecD_SecF; cl14618
1195464014646	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1195464014647	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1195464014648	SelR domain; Region: SelR; pfam01641
1195464014649	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1195464014650	antiholin-like protein LrgB; Provisional; Region: PRK04288
1195464014651	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
1195464014652	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1195464014653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014654	active site
1195464014655	phosphorylation site [posttranslational modification]
1195464014656	intermolecular recognition site; other site
1195464014657	dimerization interface [polypeptide binding]; other site
1195464014658	LytTr DNA-binding domain; Region: LytTR; pfam04397
1195464014659	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1195464014660	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1195464014661	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1195464014662	Histidine kinase; Region: His_kinase; pfam06580
1195464014663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464014664	ATP binding site [chemical binding]; other site
1195464014665	Mg2+ binding site [ion binding]; other site
1195464014666	G-X-G motif; other site
1195464014667	benzoate transport; Region: 2A0115; TIGR00895
1195464014668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464014669	putative substrate translocation pore; other site
1195464014670	BCCT family transporter; Region: BCCT; pfam02028
1195464014671	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
1195464014672	active site
1195464014673	dimer interface [polypeptide binding]; other site
1195464014674	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1195464014675	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1195464014676	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1195464014677	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464014678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464014679	NAD(P) binding site [chemical binding]; other site
1195464014680	active site
1195464014681	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
1195464014682	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1195464014683	UDP-glucose 4-epimerase; Region: PLN02240
1195464014684	NAD binding site [chemical binding]; other site
1195464014685	homodimer interface [polypeptide binding]; other site
1195464014686	active site
1195464014687	substrate binding site [chemical binding]; other site
1195464014688	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1195464014689	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1195464014690	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1195464014691	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1195464014692	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1195464014693	ATP binding site [chemical binding]; other site
1195464014694	Mg++ binding site [ion binding]; other site
1195464014695	motif III; other site
1195464014696	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464014697	nucleotide binding region [chemical binding]; other site
1195464014698	ATP-binding site [chemical binding]; other site
1195464014699	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
1195464014700	RNA binding site [nucleotide binding]; other site
1195464014701	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1195464014702	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1195464014703	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1195464014704	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1195464014705	active site
1195464014706	oligoendopeptidase F; Region: pepF; TIGR00181
1195464014707	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1195464014708	active site
1195464014709	Zn binding site [ion binding]; other site
1195464014710	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1195464014711	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464014712	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1195464014713	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1195464014714	CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129
1195464014715	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1195464014716	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1195464014717	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1195464014718	protein binding site [polypeptide binding]; other site
1195464014719	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1195464014720	YycH protein; Region: YycI; pfam09648
1195464014721	YycH protein; Region: YycH; pfam07435
1195464014722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1195464014723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1195464014724	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464014725	dimerization interface [polypeptide binding]; other site
1195464014726	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464014727	putative active site [active]
1195464014728	heme pocket [chemical binding]; other site
1195464014729	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464014730	dimer interface [polypeptide binding]; other site
1195464014731	phosphorylation site [posttranslational modification]
1195464014732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464014733	ATP binding site [chemical binding]; other site
1195464014734	Mg2+ binding site [ion binding]; other site
1195464014735	G-X-G motif; other site
1195464014736	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464014737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464014738	active site
1195464014739	phosphorylation site [posttranslational modification]
1195464014740	intermolecular recognition site; other site
1195464014741	dimerization interface [polypeptide binding]; other site
1195464014742	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464014743	DNA binding site [nucleotide binding]
1195464014744	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1195464014745	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1195464014746	GDP-binding site [chemical binding]; other site
1195464014747	ACT binding site; other site
1195464014748	IMP binding site; other site
1195464014749	replicative DNA helicase; Provisional; Region: PRK05748
1195464014750	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1195464014751	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
1195464014752	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1195464014753	Walker A motif; other site
1195464014754	ATP binding site [chemical binding]; other site
1195464014755	Walker B motif; other site
1195464014756	DNA binding loops [nucleotide binding]
1195464014757	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1195464014758	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1195464014759	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1195464014760	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1195464014761	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1195464014762	DHH family; Region: DHH; pfam01368
1195464014763	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
1195464014764	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1195464014765	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1195464014766	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1195464014767	dimer interface [polypeptide binding]; other site
1195464014768	ssDNA binding site [nucleotide binding]; other site
1195464014769	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1195464014770	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1195464014771	GTP-binding protein YchF; Reviewed; Region: PRK09601
1195464014772	YchF GTPase; Region: YchF; cd01900
1195464014773	G1 box; other site
1195464014774	GTP/Mg2+ binding site [chemical binding]; other site
1195464014775	Switch I region; other site
1195464014776	G2 box; other site
1195464014777	Switch II region; other site
1195464014778	G3 box; other site
1195464014779	G4 box; other site
1195464014780	G5 box; other site
1195464014781	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1195464014782	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1195464014783	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1195464014784	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1195464014785	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
1195464014786	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1195464014787	ParB-like nuclease domain; Region: ParB; smart00470
1195464014788	KorB domain; Region: KorB; pfam08535
1195464014789	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1195464014790	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464014791	P-loop; other site
1195464014792	Magnesium ion binding site [ion binding]; other site
1195464014793	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1195464014794	Magnesium ion binding site [ion binding]; other site
1195464014795	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1195464014796	ParB-like nuclease domain; Region: ParBc; pfam02195
1195464014797	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1195464014798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464014799	S-adenosylmethionine binding site [chemical binding]; other site
1195464014800	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1195464014801	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1195464014802	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1195464014803	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1195464014804	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1195464014805	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1195464014806	G1 box; other site
1195464014807	GTP/Mg2+ binding site [chemical binding]; other site
1195464014808	Switch I region; other site
1195464014809	G2 box; other site
1195464014810	Switch II region; other site
1195464014811	G3 box; other site
1195464014812	G4 box; other site
1195464014813	G5 box; other site
1195464014814	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1195464014815	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1195464014816	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1195464014817	G-X-X-G motif; other site
1195464014818	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1195464014819	RxxxH motif; other site
1195464014820	OxaA-like protein precursor; Validated; Region: PRK02944
1195464014821	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1195464014822	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1195464014823	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1195464014824	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1195464014825	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1195464014826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464014827	Walker A motif; other site
1195464014828	ATP binding site [chemical binding]; other site
1195464014829	Walker B motif; other site
1195464014830	arginine finger; other site
1195464014831	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1195464014832	DnaA box-binding interface [nucleotide binding]; other site
1195464014833	DNA polymerase III subunit beta; Validated; Region: PRK05643
1195464014834	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1195464014835	putative DNA binding surface [nucleotide binding]; other site
1195464014836	dimer interface [polypeptide binding]; other site
1195464014837	beta-clamp/clamp loader binding surface; other site
1195464014838	beta-clamp/translesion DNA polymerase binding surface; other site
1195464014839	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1195464014840	recombination protein F; Reviewed; Region: recF; PRK00064
1195464014841	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1195464014842	Walker A/P-loop; other site
1195464014843	ATP binding site [chemical binding]; other site
1195464014844	Q-loop/lid; other site
1195464014845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464014846	ABC transporter signature motif; other site
1195464014847	Walker B; other site
1195464014848	D-loop; other site
1195464014849	H-loop/switch region; other site
1195464014850	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1195464014851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464014852	Mg2+ binding site [ion binding]; other site
1195464014853	G-X-G motif; other site
1195464014854	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1195464014855	anchoring element; other site
1195464014856	dimer interface [polypeptide binding]; other site
1195464014857	ATP binding site [chemical binding]; other site
1195464014858	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1195464014859	active site
1195464014860	putative metal-binding site [ion binding]; other site
1195464014861	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1195464014862	DNA gyrase subunit A; Validated; Region: PRK05560
1195464014863	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1195464014864	CAP-like domain; other site
1195464014865	active site
1195464014866	primary dimer interface [polypeptide binding]; other site
1195464014867	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464014868	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464014869	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464014870	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464014871	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464014872	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1195464014873	YaaC-like Protein; Region: YaaC; pfam14175
1195464014874	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1195464014875	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1195464014876	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1195464014877	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1195464014878	active site
1195464014879	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1195464014880	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1195464014881	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1195464014882	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1195464014883	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1195464014884	active site
1195464014885	multimer interface [polypeptide binding]; other site
1195464014886	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1195464014887	predicted active site [active]
1195464014888	catalytic triad [active]
1195464014889	seryl-tRNA synthetase; Provisional; Region: PRK05431
1195464014890	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1195464014891	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1195464014892	dimer interface [polypeptide binding]; other site
1195464014893	active site
1195464014894	motif 1; other site
1195464014895	motif 2; other site
1195464014896	motif 3; other site
1195464014897	Domain of unknown function (DUF3797); Region: DUF3797; pfam12677
1195464014898	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1195464014899	DNA binding residues [nucleotide binding]
1195464014900	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1195464014901	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1195464014902	Substrate-binding site [chemical binding]; other site
1195464014903	Substrate specificity [chemical binding]; other site
1195464014904	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1195464014905	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1195464014906	Substrate-binding site [chemical binding]; other site
1195464014907	Substrate specificity [chemical binding]; other site
1195464014908	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464014909	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1195464014910	catalytic triad [active]
1195464014911	conserved cis-peptide bond; other site
1195464014912	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1195464014913	nucleoside/Zn binding site; other site
1195464014914	dimer interface [polypeptide binding]; other site
1195464014915	catalytic motif [active]
1195464014916	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1195464014917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464014918	Walker A motif; other site
1195464014919	ATP binding site [chemical binding]; other site
1195464014920	Walker B motif; other site
1195464014921	arginine finger; other site
1195464014922	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1195464014923	hypothetical protein; Validated; Region: PRK00153
1195464014924	recombination protein RecR; Reviewed; Region: recR; PRK00076
1195464014925	RecR protein; Region: RecR; pfam02132
1195464014926	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1195464014927	putative active site [active]
1195464014928	putative metal-binding site [ion binding]; other site
1195464014929	tetramer interface [polypeptide binding]; other site
1195464014930	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1195464014931	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
1195464014932	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
1195464014933	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1195464014934	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1195464014935	homodimer interface [polypeptide binding]; other site
1195464014936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464014937	catalytic residue [active]
1195464014938	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1195464014939	thymidylate kinase; Validated; Region: tmk; PRK00698
1195464014940	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1195464014941	TMP-binding site; other site
1195464014942	ATP-binding site [chemical binding]; other site
1195464014943	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1195464014944	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1195464014945	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1195464014946	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1195464014947	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1195464014948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464014949	S-adenosylmethionine binding site [chemical binding]; other site
1195464014950	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1195464014951	putative active site [active]
1195464014952	GIY-YIG motif/motif A; other site
1195464014953	putative metal binding site [ion binding]; other site
1195464014954	Predicted methyltransferases [General function prediction only]; Region: COG0313
1195464014955	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1195464014956	putative SAM binding site [chemical binding]; other site
1195464014957	putative homodimer interface [polypeptide binding]; other site
1195464014958	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1195464014959	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1195464014960	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1195464014961	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1195464014962	active site
1195464014963	HIGH motif; other site
1195464014964	KMSKS motif; other site
1195464014965	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1195464014966	tRNA binding surface [nucleotide binding]; other site
1195464014967	anticodon binding site; other site
1195464014968	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1195464014969	dimer interface [polypeptide binding]; other site
1195464014970	putative tRNA-binding site [nucleotide binding]; other site
1195464014971	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1195464014972	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1195464014973	active site
1195464014974	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1195464014975	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1195464014976	putative active site [active]
1195464014977	putative metal binding site [ion binding]; other site
1195464014978	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1195464014979	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1195464014980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464014981	S-adenosylmethionine binding site [chemical binding]; other site
1195464014982	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
1195464014983	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1195464014984	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1195464014985	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1195464014986	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1195464014987	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1195464014988	pur operon repressor; Provisional; Region: PRK09213
1195464014989	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1195464014990	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464014991	active site
1195464014992	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1195464014993	homotrimer interaction site [polypeptide binding]; other site
1195464014994	putative active site [active]
1195464014995	regulatory protein SpoVG; Reviewed; Region: PRK13259
1195464014996	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1195464014997	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1195464014998	Substrate binding site; other site
1195464014999	Mg++ binding site; other site
1195464015000	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1195464015001	active site
1195464015002	substrate binding site [chemical binding]; other site
1195464015003	CoA binding site [chemical binding]; other site
1195464015004	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1195464015005	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1195464015006	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464015007	active site
1195464015008	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1195464015009	putative active site [active]
1195464015010	catalytic residue [active]
1195464015011	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
1195464015012	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1195464015013	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1195464015014	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1195464015015	ATP binding site [chemical binding]; other site
1195464015016	putative Mg++ binding site [ion binding]; other site
1195464015017	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464015018	nucleotide binding region [chemical binding]; other site
1195464015019	ATP-binding site [chemical binding]; other site
1195464015020	TRCF domain; Region: TRCF; pfam03461
1195464015021	stage V sporulation protein T; Region: spore_V_T; TIGR02851
1195464015022	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
1195464015023	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1195464015024	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
1195464015025	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1195464015026	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1195464015027	homodimer interface [polypeptide binding]; other site
1195464015028	metal binding site [ion binding]; metal-binding site
1195464015029	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1195464015030	homodimer interface [polypeptide binding]; other site
1195464015031	active site
1195464015032	putative chemical substrate binding site [chemical binding]; other site
1195464015033	metal binding site [ion binding]; metal-binding site
1195464015034	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1195464015035	RNA binding surface [nucleotide binding]; other site
1195464015036	sporulation protein YabP; Region: spore_yabP; TIGR02892
1195464015037	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
1195464015038	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1195464015039	Septum formation initiator; Region: DivIC; pfam04977
1195464015040	hypothetical protein; Provisional; Region: PRK08582
1195464015041	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1195464015042	RNA binding site [nucleotide binding]; other site
1195464015043	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1195464015044	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1195464015045	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1195464015046	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1195464015047	Ligand Binding Site [chemical binding]; other site
1195464015048	TilS substrate binding domain; Region: TilS; pfam09179
1195464015049	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1195464015050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464015051	active site
1195464015052	FtsH Extracellular; Region: FtsH_ext; pfam06480
1195464015053	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1195464015054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464015055	Walker A motif; other site
1195464015056	ATP binding site [chemical binding]; other site
1195464015057	Walker B motif; other site
1195464015058	arginine finger; other site
1195464015059	Peptidase family M41; Region: Peptidase_M41; pfam01434
1195464015060	pantothenate kinase; Reviewed; Region: PRK13318
1195464015061	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1195464015062	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1195464015063	dimerization interface [polypeptide binding]; other site
1195464015064	domain crossover interface; other site
1195464015065	redox-dependent activation switch; other site
1195464015066	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1195464015067	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1195464015068	dimer interface [polypeptide binding]; other site
1195464015069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464015070	catalytic residue [active]
1195464015071	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1195464015072	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1195464015073	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1195464015074	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1195464015075	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1195464015076	glutamine binding [chemical binding]; other site
1195464015077	catalytic triad [active]
1195464015078	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1195464015079	4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650
1195464015080	homodimer interface [polypeptide binding]; other site
1195464015081	substrate-cofactor binding pocket; other site
1195464015082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464015083	catalytic residue [active]
1195464015084	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1195464015085	dihydropteroate synthase; Region: DHPS; TIGR01496
1195464015086	substrate binding pocket [chemical binding]; other site
1195464015087	dimer interface [polypeptide binding]; other site
1195464015088	inhibitor binding site; inhibition site
1195464015089	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1195464015090	homooctamer interface [polypeptide binding]; other site
1195464015091	active site
1195464015092	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1195464015093	catalytic center binding site [active]
1195464015094	ATP binding site [chemical binding]; other site
1195464015095	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1195464015096	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1195464015097	FMN binding site [chemical binding]; other site
1195464015098	active site
1195464015099	catalytic residues [active]
1195464015100	substrate binding site [chemical binding]; other site
1195464015101	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1195464015102	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1195464015103	dimer interface [polypeptide binding]; other site
1195464015104	putative anticodon binding site; other site
1195464015105	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1195464015106	motif 1; other site
1195464015107	active site
1195464015108	motif 2; other site
1195464015109	motif 3; other site
1195464015110	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1195464015111	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1195464015112	UvrB/uvrC motif; Region: UVR; pfam02151
1195464015113	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1195464015114	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1195464015115	ADP binding site [chemical binding]; other site
1195464015116	phosphagen binding site; other site
1195464015117	substrate specificity loop; other site
1195464015118	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1195464015119	Clp amino terminal domain; Region: Clp_N; pfam02861
1195464015120	Clp amino terminal domain; Region: Clp_N; pfam02861
1195464015121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464015122	Walker A motif; other site
1195464015123	ATP binding site [chemical binding]; other site
1195464015124	Walker B motif; other site
1195464015125	arginine finger; other site
1195464015126	UvrB/uvrC motif; Region: UVR; pfam02151
1195464015127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464015128	Walker A motif; other site
1195464015129	ATP binding site [chemical binding]; other site
1195464015130	Walker B motif; other site
1195464015131	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1195464015132	DNA repair protein RadA; Provisional; Region: PRK11823
1195464015133	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1195464015134	Walker A motif/ATP binding site; other site
1195464015135	ATP binding site [chemical binding]; other site
1195464015136	Walker B motif; other site
1195464015137	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1195464015138	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1195464015139	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1195464015140	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1195464015141	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1195464015142	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1195464015143	putative active site [active]
1195464015144	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1195464015145	substrate binding site; other site
1195464015146	dimer interface; other site
1195464015147	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1195464015148	homotrimer interaction site [polypeptide binding]; other site
1195464015149	zinc binding site [ion binding]; other site
1195464015150	CDP-binding sites; other site
1195464015151	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1195464015152	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1195464015153	HIGH motif; other site
1195464015154	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1195464015155	active site
1195464015156	KMSKS motif; other site
1195464015157	serine O-acetyltransferase; Region: cysE; TIGR01172
1195464015158	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1195464015159	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1195464015160	trimer interface [polypeptide binding]; other site
1195464015161	active site
1195464015162	substrate binding site [chemical binding]; other site
1195464015163	CoA binding site [chemical binding]; other site
1195464015164	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1195464015165	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1195464015166	active site
1195464015167	HIGH motif; other site
1195464015168	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1195464015169	KMSKS motif; other site
1195464015170	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1195464015171	tRNA binding surface [nucleotide binding]; other site
1195464015172	anticodon binding site; other site
1195464015173	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1195464015174	active site
1195464015175	metal binding site [ion binding]; metal-binding site
1195464015176	dimerization interface [polypeptide binding]; other site
1195464015177	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1195464015178	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1195464015179	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1195464015180	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1195464015181	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
1195464015182	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464015183	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1195464015184	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1195464015185	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1195464015186	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1195464015187	putative homodimer interface [polypeptide binding]; other site
1195464015188	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1195464015189	heterodimer interface [polypeptide binding]; other site
1195464015190	homodimer interface [polypeptide binding]; other site
1195464015191	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1195464015192	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1195464015193	23S rRNA interface [nucleotide binding]; other site
1195464015194	L7/L12 interface [polypeptide binding]; other site
1195464015195	putative thiostrepton binding site; other site
1195464015196	L25 interface [polypeptide binding]; other site
1195464015197	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1195464015198	mRNA/rRNA interface [nucleotide binding]; other site
1195464015199	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1195464015200	23S rRNA interface [nucleotide binding]; other site
1195464015201	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1195464015202	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1195464015203	core dimer interface [polypeptide binding]; other site
1195464015204	peripheral dimer interface [polypeptide binding]; other site
1195464015205	L10 interface [polypeptide binding]; other site
1195464015206	L11 interface [polypeptide binding]; other site
1195464015207	putative EF-Tu interaction site [polypeptide binding]; other site
1195464015208	putative EF-G interaction site [polypeptide binding]; other site
1195464015209	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1195464015210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015211	S-adenosylmethionine binding site [chemical binding]; other site
1195464015212	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
1195464015213	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1195464015214	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1195464015215	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1195464015216	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
1195464015217	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1195464015218	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1195464015219	RPB10 interaction site [polypeptide binding]; other site
1195464015220	RPB1 interaction site [polypeptide binding]; other site
1195464015221	RPB11 interaction site [polypeptide binding]; other site
1195464015222	RPB3 interaction site [polypeptide binding]; other site
1195464015223	RPB12 interaction site [polypeptide binding]; other site
1195464015224	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1195464015225	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1195464015226	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1195464015227	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1195464015228	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1195464015229	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1195464015230	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1195464015231	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1195464015232	G-loop; other site
1195464015233	DNA binding site [nucleotide binding]
1195464015234	hypothetical protein; Provisional; Region: PRK06683
1195464015235	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1195464015236	S17 interaction site [polypeptide binding]; other site
1195464015237	S8 interaction site; other site
1195464015238	16S rRNA interaction site [nucleotide binding]; other site
1195464015239	streptomycin interaction site [chemical binding]; other site
1195464015240	23S rRNA interaction site [nucleotide binding]; other site
1195464015241	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1195464015242	30S ribosomal protein S7; Validated; Region: PRK05302
1195464015243	elongation factor G; Reviewed; Region: PRK00007
1195464015244	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1195464015245	G1 box; other site
1195464015246	putative GEF interaction site [polypeptide binding]; other site
1195464015247	GTP/Mg2+ binding site [chemical binding]; other site
1195464015248	Switch I region; other site
1195464015249	G2 box; other site
1195464015250	G3 box; other site
1195464015251	Switch II region; other site
1195464015252	G4 box; other site
1195464015253	G5 box; other site
1195464015254	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1195464015255	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1195464015256	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1195464015257	elongation factor Tu; Reviewed; Region: PRK00049
1195464015258	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1195464015259	G1 box; other site
1195464015260	GEF interaction site [polypeptide binding]; other site
1195464015261	GTP/Mg2+ binding site [chemical binding]; other site
1195464015262	Switch I region; other site
1195464015263	G2 box; other site
1195464015264	G3 box; other site
1195464015265	Switch II region; other site
1195464015266	G4 box; other site
1195464015267	G5 box; other site
1195464015268	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1195464015269	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1195464015270	Antibiotic Binding Site [chemical binding]; other site
1195464015271	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1195464015272	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1195464015273	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1195464015274	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1195464015275	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1195464015276	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1195464015277	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1195464015278	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1195464015279	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1195464015280	putative translocon binding site; other site
1195464015281	protein-rRNA interface [nucleotide binding]; other site
1195464015282	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1195464015283	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1195464015284	G-X-X-G motif; other site
1195464015285	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1195464015286	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1195464015287	23S rRNA interface [nucleotide binding]; other site
1195464015288	5S rRNA interface [nucleotide binding]; other site
1195464015289	putative antibiotic binding site [chemical binding]; other site
1195464015290	L25 interface [polypeptide binding]; other site
1195464015291	L27 interface [polypeptide binding]; other site
1195464015292	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1195464015293	23S rRNA interface [nucleotide binding]; other site
1195464015294	putative translocon interaction site; other site
1195464015295	signal recognition particle (SRP54) interaction site; other site
1195464015296	L23 interface [polypeptide binding]; other site
1195464015297	trigger factor interaction site; other site
1195464015298	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1195464015299	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1195464015300	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1195464015301	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1195464015302	RNA binding site [nucleotide binding]; other site
1195464015303	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1195464015304	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1195464015305	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1195464015306	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1195464015307	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1195464015308	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1195464015309	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1195464015310	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1195464015311	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1195464015312	5S rRNA interface [nucleotide binding]; other site
1195464015313	L27 interface [polypeptide binding]; other site
1195464015314	23S rRNA interface [nucleotide binding]; other site
1195464015315	L5 interface [polypeptide binding]; other site
1195464015316	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1195464015317	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1195464015318	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1195464015319	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1195464015320	23S rRNA binding site [nucleotide binding]; other site
1195464015321	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1195464015322	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
1195464015323	SecY translocase; Region: SecY; pfam00344
1195464015324	adenylate kinase; Reviewed; Region: adk; PRK00279
1195464015325	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1195464015326	AMP-binding site [chemical binding]; other site
1195464015327	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1195464015328	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1195464015329	active site
1195464015330	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1195464015331	rRNA binding site [nucleotide binding]; other site
1195464015332	predicted 30S ribosome binding site; other site
1195464015333	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1195464015334	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1195464015335	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1195464015336	30S ribosomal protein S11; Validated; Region: PRK05309
1195464015337	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1195464015338	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1195464015339	alphaNTD - beta interaction site [polypeptide binding]; other site
1195464015340	alphaNTD homodimer interface [polypeptide binding]; other site
1195464015341	alphaNTD - beta' interaction site [polypeptide binding]; other site
1195464015342	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1195464015343	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1195464015344	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1195464015345	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1195464015346	Walker A/P-loop; other site
1195464015347	ATP binding site [chemical binding]; other site
1195464015348	Q-loop/lid; other site
1195464015349	ABC transporter signature motif; other site
1195464015350	Walker B; other site
1195464015351	D-loop; other site
1195464015352	H-loop/switch region; other site
1195464015353	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1195464015354	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1195464015355	Walker A/P-loop; other site
1195464015356	ATP binding site [chemical binding]; other site
1195464015357	Q-loop/lid; other site
1195464015358	ABC transporter signature motif; other site
1195464015359	Walker B; other site
1195464015360	D-loop; other site
1195464015361	H-loop/switch region; other site
1195464015362	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1195464015363	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1195464015364	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1195464015365	dimerization interface 3.5A [polypeptide binding]; other site
1195464015366	active site
1195464015367	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1195464015368	23S rRNA interface [nucleotide binding]; other site
1195464015369	L3 interface [polypeptide binding]; other site
1195464015370	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1195464015371	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
1195464015372	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1195464015373	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1195464015374	active site
1195464015375	metal binding site [ion binding]; metal-binding site
1195464015376	Domain of unknown function DUF59; Region: DUF59; cl00941
1195464015377	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1195464015378	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1195464015379	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
1195464015380	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464015381	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
1195464015382	NodB motif; other site
1195464015383	putative active site [active]
1195464015384	putative catalytic site [active]
1195464015385	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1195464015386	Arginase family; Region: Arginase; cd09989
1195464015387	agmatinase; Region: agmatinase; TIGR01230
1195464015388	active site
1195464015389	Mn binding site [ion binding]; other site
1195464015390	oligomer interface [polypeptide binding]; other site
1195464015391	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1195464015392	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1195464015393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1195464015394	YbbR-like protein; Region: YbbR; pfam07949
1195464015395	YbbR-like protein; Region: YbbR; pfam07949
1195464015396	YbbR-like protein; Region: YbbR; pfam07949
1195464015397	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1195464015398	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1195464015399	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1195464015400	active site
1195464015401	substrate binding site [chemical binding]; other site
1195464015402	metal binding site [ion binding]; metal-binding site
1195464015403	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1195464015404	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1195464015405	glutaminase active site [active]
1195464015406	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1195464015407	dimer interface [polypeptide binding]; other site
1195464015408	active site
1195464015409	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1195464015410	dimer interface [polypeptide binding]; other site
1195464015411	active site
1195464015412	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1195464015413	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464015414	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
1195464015415	DoxX; Region: DoxX; cl17842
1195464015416	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859
1195464015417	classical (c) SDRs; Region: SDR_c; cd05233
1195464015418	NAD(P) binding site [chemical binding]; other site
1195464015419	active site
1195464015420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1195464015421	ABC-ATPase subunit interface; other site
1195464015422	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1195464015423	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1195464015424	Walker A/P-loop; other site
1195464015425	ATP binding site [chemical binding]; other site
1195464015426	Q-loop/lid; other site
1195464015427	ABC transporter signature motif; other site
1195464015428	Walker B; other site
1195464015429	D-loop; other site
1195464015430	H-loop/switch region; other site
1195464015431	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1195464015432	NIL domain; Region: NIL; pfam09383
1195464015433	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1195464015434	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1195464015435	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1195464015436	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1195464015437	putative NAD(P) binding site [chemical binding]; other site
1195464015438	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464015439	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1195464015440	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1195464015441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464015442	putative substrate translocation pore; other site
1195464015443	Domain of unknown function (DUF3981); Region: DUF3981; pfam13139
1195464015444	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1195464015445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464015446	putative substrate translocation pore; other site
1195464015447	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
1195464015448	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
1195464015449	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464015450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464015451	dimer interface [polypeptide binding]; other site
1195464015452	conserved gate region; other site
1195464015453	putative PBP binding loops; other site
1195464015454	ABC-ATPase subunit interface; other site
1195464015455	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1195464015456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464015457	dimer interface [polypeptide binding]; other site
1195464015458	conserved gate region; other site
1195464015459	putative PBP binding loops; other site
1195464015460	ABC-ATPase subunit interface; other site
1195464015461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464015462	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1195464015463	Walker A/P-loop; other site
1195464015464	ATP binding site [chemical binding]; other site
1195464015465	Q-loop/lid; other site
1195464015466	ABC transporter signature motif; other site
1195464015467	Walker B; other site
1195464015468	D-loop; other site
1195464015469	H-loop/switch region; other site
1195464015470	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1195464015471	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1195464015472	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464015473	Walker A/P-loop; other site
1195464015474	ATP binding site [chemical binding]; other site
1195464015475	Q-loop/lid; other site
1195464015476	ABC transporter signature motif; other site
1195464015477	Walker B; other site
1195464015478	D-loop; other site
1195464015479	H-loop/switch region; other site
1195464015480	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1195464015481	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464015482	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464015483	peptide binding site [polypeptide binding]; other site
1195464015484	YusW-like protein; Region: YusW; pfam14039
1195464015485	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464015486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1195464015487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1195464015488	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464015489	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464015490	peptide binding site [polypeptide binding]; other site
1195464015491	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1195464015492	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1195464015493	peptide binding site [polypeptide binding]; other site
1195464015494	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1195464015495	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1195464015496	active site
1195464015497	catalytic tetrad [active]
1195464015498	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634
1195464015499	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1195464015500	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1195464015501	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1195464015502	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1195464015503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464015504	dimer interface [polypeptide binding]; other site
1195464015505	conserved gate region; other site
1195464015506	putative PBP binding loops; other site
1195464015507	ABC-ATPase subunit interface; other site
1195464015508	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1195464015509	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1195464015510	dimerization interface [polypeptide binding]; other site
1195464015511	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464015512	membrane-bound complex binding site; other site
1195464015513	hinge residues; other site
1195464015514	DNA binding domain, excisionase family; Region: excise; TIGR01764
1195464015515	PBP superfamily domain; Region: PBP_like; pfam12727
1195464015516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1195464015517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1195464015518	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1195464015519	putative dimerization interface [polypeptide binding]; other site
1195464015520	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464015521	EamA-like transporter family; Region: EamA; pfam00892
1195464015522	YrzO-like protein; Region: YrzO; pfam14142
1195464015523	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464015524	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464015525	DNA binding site [nucleotide binding]
1195464015526	domain linker motif; other site
1195464015527	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1195464015528	putative ligand binding site [chemical binding]; other site
1195464015529	putative dimerization interface [polypeptide binding]; other site
1195464015530	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1195464015531	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464015532	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1195464015533	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1195464015534	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1195464015535	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1195464015536	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1195464015537	active site
1195464015538	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
1195464015539	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1195464015540	NodB motif; other site
1195464015541	putative active site [active]
1195464015542	putative catalytic site [active]
1195464015543	putative Zn binding site [ion binding]; other site
1195464015544	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
1195464015545	lysozyme catalytic site [active]
1195464015546	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1195464015547	nucleotide binding site/active site [active]
1195464015548	HIT family signature motif; other site
1195464015549	catalytic residue [active]
1195464015550	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464015551	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464015552	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464015553	ABC transporter; Region: ABC_tran_2; pfam12848
1195464015554	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464015555	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1195464015556	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1195464015557	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1195464015558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464015559	dimer interface [polypeptide binding]; other site
1195464015560	conserved gate region; other site
1195464015561	putative PBP binding loops; other site
1195464015562	ABC-ATPase subunit interface; other site
1195464015563	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1195464015564	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1195464015565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464015566	dimer interface [polypeptide binding]; other site
1195464015567	conserved gate region; other site
1195464015568	putative PBP binding loops; other site
1195464015569	ABC-ATPase subunit interface; other site
1195464015570	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1195464015571	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464015572	Walker A/P-loop; other site
1195464015573	ATP binding site [chemical binding]; other site
1195464015574	Q-loop/lid; other site
1195464015575	ABC transporter signature motif; other site
1195464015576	Walker B; other site
1195464015577	D-loop; other site
1195464015578	H-loop/switch region; other site
1195464015579	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1195464015580	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1195464015581	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1195464015582	Walker A/P-loop; other site
1195464015583	ATP binding site [chemical binding]; other site
1195464015584	Q-loop/lid; other site
1195464015585	ABC transporter signature motif; other site
1195464015586	Walker B; other site
1195464015587	D-loop; other site
1195464015588	H-loop/switch region; other site
1195464015589	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1195464015590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464015591	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1195464015592	active site
1195464015593	motif I; other site
1195464015594	motif II; other site
1195464015595	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464015596	motif II; other site
1195464015597	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1195464015598	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
1195464015599	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
1195464015600	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
1195464015601	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
1195464015602	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
1195464015603	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1195464015604	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1195464015605	dimer interface [polypeptide binding]; other site
1195464015606	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1195464015607	active site
1195464015608	Fe binding site [ion binding]; other site
1195464015609	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1195464015610	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1195464015611	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1195464015612	amino acid transporter; Region: 2A0306; TIGR00909
1195464015613	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1195464015614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464015615	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464015616	putative substrate translocation pore; other site
1195464015617	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1195464015618	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1195464015619	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1195464015620	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1195464015621	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1195464015622	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1195464015623	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1195464015624	helicase 45; Provisional; Region: PTZ00424
1195464015625	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1195464015626	ATP binding site [chemical binding]; other site
1195464015627	Mg++ binding site [ion binding]; other site
1195464015628	motif III; other site
1195464015629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1195464015630	nucleotide binding region [chemical binding]; other site
1195464015631	ATP-binding site [chemical binding]; other site
1195464015632	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1195464015633	Rhomboid family; Region: Rhomboid; pfam01694
1195464015634	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1195464015635	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1195464015636	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1195464015637	alanine racemase; Reviewed; Region: alr; PRK00053
1195464015638	active site
1195464015639	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1195464015640	dimer interface [polypeptide binding]; other site
1195464015641	substrate binding site [chemical binding]; other site
1195464015642	catalytic residues [active]
1195464015643	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1195464015644	PemK-like protein; Region: PemK; pfam02452
1195464015645	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1195464015646	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1195464015647	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1195464015648	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1195464015649	RNA binding site [nucleotide binding]; other site
1195464015650	SprT homologues; Region: SprT; cl01182
1195464015651	hypothetical protein; Provisional; Region: PRK04351
1195464015652	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1195464015653	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1195464015654	Glycoprotease family; Region: Peptidase_M22; pfam00814
1195464015655	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1195464015656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464015657	Coenzyme A binding pocket [chemical binding]; other site
1195464015658	UGMP family protein; Validated; Region: PRK09604
1195464015659	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1195464015660	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1195464015661	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1195464015662	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464015663	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464015664	ABC transporter; Region: ABC_tran_2; pfam12848
1195464015665	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1195464015666	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1195464015667	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1195464015668	CoA binding domain; Region: CoA_binding; pfam02629
1195464015669	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
1195464015670	CAAX protease self-immunity; Region: Abi; pfam02517
1195464015671	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1195464015672	oligomerisation interface [polypeptide binding]; other site
1195464015673	mobile loop; other site
1195464015674	roof hairpin; other site
1195464015675	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1195464015676	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1195464015677	ring oligomerisation interface [polypeptide binding]; other site
1195464015678	ATP/Mg binding site [chemical binding]; other site
1195464015679	stacking interactions; other site
1195464015680	hinge regions; other site
1195464015681	conserved hypothetical integral membrane protein; Region: TIGR03766
1195464015682	GMP synthase; Reviewed; Region: guaA; PRK00074
1195464015683	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1195464015684	AMP/PPi binding site [chemical binding]; other site
1195464015685	candidate oxyanion hole; other site
1195464015686	catalytic triad [active]
1195464015687	potential glutamine specificity residues [chemical binding]; other site
1195464015688	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1195464015689	ATP Binding subdomain [chemical binding]; other site
1195464015690	Ligand Binding sites [chemical binding]; other site
1195464015691	Dimerization subdomain; other site
1195464015692	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1195464015693	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1195464015694	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1195464015695	Replication initiation factor; Region: Rep_trans; pfam02486
1195464015696	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1195464015697	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1195464015698	Int/Topo IB signature motif; other site
1195464015699	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464015700	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1195464015701	active site
1195464015702	metal binding site [ion binding]; metal-binding site
1195464015703	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1195464015704	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464015705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464015706	active site
1195464015707	phosphorylation site [posttranslational modification]
1195464015708	intermolecular recognition site; other site
1195464015709	dimerization interface [polypeptide binding]; other site
1195464015710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464015711	DNA binding site [nucleotide binding]
1195464015712	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464015713	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464015714	dimerization interface [polypeptide binding]; other site
1195464015715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464015716	dimer interface [polypeptide binding]; other site
1195464015717	phosphorylation site [posttranslational modification]
1195464015718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464015719	ATP binding site [chemical binding]; other site
1195464015720	Mg2+ binding site [ion binding]; other site
1195464015721	G-X-G motif; other site
1195464015722	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1195464015723	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1195464015724	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1195464015725	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1195464015726	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1195464015727	catalytic residues [active]
1195464015728	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
1195464015729	putative ligand binding site [chemical binding]; other site
1195464015730	putative catalytic site [active]
1195464015731	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464015732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015733	S-adenosylmethionine binding site [chemical binding]; other site
1195464015734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015735	S-adenosylmethionine binding site [chemical binding]; other site
1195464015736	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1195464015737	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464015738	UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264
1195464015739	putative NAD(P) binding site [chemical binding]; other site
1195464015740	active site
1195464015741	putative substrate binding site [chemical binding]; other site
1195464015742	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1195464015743	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1195464015744	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464015745	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464015746	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464015747	active site
1195464015748	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464015749	EamA-like transporter family; Region: EamA; pfam00892
1195464015750	EamA-like transporter family; Region: EamA; pfam00892
1195464015751	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1195464015752	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1195464015753	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1195464015754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464015755	ABC transporter; Region: ABC_tran; pfam00005
1195464015756	Q-loop/lid; other site
1195464015757	ABC transporter signature motif; other site
1195464015758	Walker B; other site
1195464015759	D-loop; other site
1195464015760	H-loop/switch region; other site
1195464015761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464015762	dimer interface [polypeptide binding]; other site
1195464015763	phosphorylation site [posttranslational modification]
1195464015764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464015765	ATP binding site [chemical binding]; other site
1195464015766	Mg2+ binding site [ion binding]; other site
1195464015767	G-X-G motif; other site
1195464015768	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464015769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464015770	active site
1195464015771	phosphorylation site [posttranslational modification]
1195464015772	intermolecular recognition site; other site
1195464015773	dimerization interface [polypeptide binding]; other site
1195464015774	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464015775	DNA binding site [nucleotide binding]
1195464015776	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
1195464015777	putative ligand binding site [chemical binding]; other site
1195464015778	putative catalytic site [active]
1195464015779	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464015780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015781	S-adenosylmethionine binding site [chemical binding]; other site
1195464015782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015783	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1195464015784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464015785	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464015786	NAD(P) binding site [chemical binding]; other site
1195464015787	active site
1195464015788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015789	S-adenosylmethionine binding site [chemical binding]; other site
1195464015790	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1195464015791	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1195464015792	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464015793	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464015794	active site
1195464015795	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464015796	EamA-like transporter family; Region: EamA; pfam00892
1195464015797	EamA-like transporter family; Region: EamA; pfam00892
1195464015798	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1195464015799	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1195464015800	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1195464015801	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1195464015802	NAD binding site [chemical binding]; other site
1195464015803	ATP-grasp domain; Region: ATP-grasp; pfam02222
1195464015804	adenylosuccinate lyase; Provisional; Region: PRK07492
1195464015805	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1195464015806	tetramer interface [polypeptide binding]; other site
1195464015807	active site
1195464015808	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1195464015809	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1195464015810	ATP binding site [chemical binding]; other site
1195464015811	active site
1195464015812	substrate binding site [chemical binding]; other site
1195464015813	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1195464015814	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1195464015815	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1195464015816	putative active site [active]
1195464015817	catalytic triad [active]
1195464015818	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1195464015819	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1195464015820	dimerization interface [polypeptide binding]; other site
1195464015821	ATP binding site [chemical binding]; other site
1195464015822	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1195464015823	dimerization interface [polypeptide binding]; other site
1195464015824	ATP binding site [chemical binding]; other site
1195464015825	amidophosphoribosyltransferase; Provisional; Region: PRK06781
1195464015826	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1195464015827	active site
1195464015828	tetramer interface [polypeptide binding]; other site
1195464015829	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1195464015830	active site
1195464015831	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1195464015832	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1195464015833	dimerization interface [polypeptide binding]; other site
1195464015834	putative ATP binding site [chemical binding]; other site
1195464015835	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1195464015836	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1195464015837	active site
1195464015838	substrate binding site [chemical binding]; other site
1195464015839	cosubstrate binding site; other site
1195464015840	catalytic site [active]
1195464015841	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1195464015842	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1195464015843	purine monophosphate binding site [chemical binding]; other site
1195464015844	dimer interface [polypeptide binding]; other site
1195464015845	putative catalytic residues [active]
1195464015846	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1195464015847	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1195464015848	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1195464015849	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1195464015850	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1195464015851	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1195464015852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1195464015853	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1195464015854	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1195464015855	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1195464015856	PcrB family; Region: PcrB; pfam01884
1195464015857	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1195464015858	substrate binding site [chemical binding]; other site
1195464015859	putative active site [active]
1195464015860	dimer interface [polypeptide binding]; other site
1195464015861	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1195464015862	Part of AAA domain; Region: AAA_19; pfam13245
1195464015863	Family description; Region: UvrD_C_2; pfam13538
1195464015864	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1195464015865	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1195464015866	nucleotide binding pocket [chemical binding]; other site
1195464015867	K-X-D-G motif; other site
1195464015868	catalytic site [active]
1195464015869	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1195464015870	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1195464015871	Dimer interface [polypeptide binding]; other site
1195464015872	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1195464015873	putative dimer interface [polypeptide binding]; other site
1195464015874	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1195464015875	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1195464015876	putative dimer interface [polypeptide binding]; other site
1195464015877	hypothetical protein; Provisional; Region: PRK10621
1195464015878	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1195464015879	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1195464015880	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1195464015881	Glutamate binding site [chemical binding]; other site
1195464015882	homodimer interface [polypeptide binding]; other site
1195464015883	NAD binding site [chemical binding]; other site
1195464015884	catalytic residues [active]
1195464015885	Isochorismatase family; Region: Isochorismatase; pfam00857
1195464015886	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1195464015887	catalytic triad [active]
1195464015888	conserved cis-peptide bond; other site
1195464015889	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1195464015890	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1195464015891	Walker A/P-loop; other site
1195464015892	ATP binding site [chemical binding]; other site
1195464015893	Q-loop/lid; other site
1195464015894	ABC transporter signature motif; other site
1195464015895	Walker B; other site
1195464015896	D-loop; other site
1195464015897	H-loop/switch region; other site
1195464015898	NIL domain; Region: NIL; pfam09383
1195464015899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464015900	dimer interface [polypeptide binding]; other site
1195464015901	conserved gate region; other site
1195464015902	ABC-ATPase subunit interface; other site
1195464015903	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1195464015904	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1195464015905	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1195464015906	Protein of unknown function (DUF3926); Region: DUF3926; pfam13080
1195464015907	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1195464015908	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1195464015909	P loop; other site
1195464015910	Nucleotide binding site [chemical binding]; other site
1195464015911	DTAP/Switch II; other site
1195464015912	Switch I; other site
1195464015913	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1195464015914	putative dimer interface [polypeptide binding]; other site
1195464015915	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464015916	MarR family; Region: MarR; pfam01047
1195464015917	MarR family; Region: MarR_2; cl17246
1195464015918	yiaA/B two helix domain; Region: YiaAB; pfam05360
1195464015919	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1195464015920	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1195464015921	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1195464015922	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1195464015923	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1195464015924	GatB domain; Region: GatB_Yqey; pfam02637
1195464015925	putative lipid kinase; Reviewed; Region: PRK13337
1195464015926	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1195464015927	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1195464015928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1195464015929	motif II; other site
1195464015930	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
1195464015931	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464015932	inhibitor-cofactor binding pocket; inhibition site
1195464015933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464015934	catalytic residue [active]
1195464015935	PAS domain; Region: PAS_9; pfam13426
1195464015936	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464015937	putative active site [active]
1195464015938	heme pocket [chemical binding]; other site
1195464015939	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464015940	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1195464015941	Walker A motif; other site
1195464015942	ATP binding site [chemical binding]; other site
1195464015943	Walker B motif; other site
1195464015944	arginine finger; other site
1195464015945	succinic semialdehyde dehydrogenase; Region: PLN02278
1195464015946	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1195464015947	tetramerization interface [polypeptide binding]; other site
1195464015948	NAD(P) binding site [chemical binding]; other site
1195464015949	catalytic residues [active]
1195464015950	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1195464015951	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1195464015952	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1195464015953	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1195464015954	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464015955	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1195464015956	putative active site [active]
1195464015957	putative metal binding site [ion binding]; other site
1195464015958	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1195464015959	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1195464015960	putative active site [active]
1195464015961	putative metal binding site [ion binding]; other site
1195464015962	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1195464015963	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1195464015964	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464015965	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1195464015966	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1195464015967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015968	S-adenosylmethionine binding site [chemical binding]; other site
1195464015969	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1195464015970	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1195464015971	FMN binding site [chemical binding]; other site
1195464015972	active site
1195464015973	catalytic residues [active]
1195464015974	substrate binding site [chemical binding]; other site
1195464015975	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1195464015976	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1195464015977	GAF domain; Region: GAF_3; pfam13492
1195464015978	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1195464015979	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464015980	dimer interface [polypeptide binding]; other site
1195464015981	phosphorylation site [posttranslational modification]
1195464015982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464015983	ATP binding site [chemical binding]; other site
1195464015984	Mg2+ binding site [ion binding]; other site
1195464015985	G-X-G motif; other site
1195464015986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1195464015987	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1195464015988	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1195464015989	Protein of unknown function DUF45; Region: DUF45; pfam01863
1195464015990	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1195464015991	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1195464015992	active site
1195464015993	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1195464015994	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464015995	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
1195464015996	metal binding site [ion binding]; metal-binding site
1195464015997	putative dimer interface [polypeptide binding]; other site
1195464015998	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464015999	S-adenosylmethionine binding site [chemical binding]; other site
1195464016000	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1195464016001	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1195464016002	catalytic residue [active]
1195464016003	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1195464016004	catalytic residues [active]
1195464016005	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464016006	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1195464016007	peroxiredoxin; Region: AhpC; TIGR03137
1195464016008	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1195464016009	dimer interface [polypeptide binding]; other site
1195464016010	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1195464016011	catalytic triad [active]
1195464016012	peroxidatic and resolving cysteines [active]
1195464016013	5-methylribose kinase; Reviewed; Region: PRK12396
1195464016014	Phosphotransferase enzyme family; Region: APH; pfam01636
1195464016015	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1195464016016	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1195464016017	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
1195464016018	intersubunit interface [polypeptide binding]; other site
1195464016019	active site
1195464016020	Zn2+ binding site [ion binding]; other site
1195464016021	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464016022	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464016023	ABC-ATPase subunit  interface; other site
1195464016024	dimer interface [polypeptide binding]; other site
1195464016025	putative PBP binding regions; other site
1195464016026	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464016027	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464016028	ABC-ATPase subunit  interface; other site
1195464016029	dimer interface [polypeptide binding]; other site
1195464016030	putative PBP binding regions; other site
1195464016031	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464016032	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
1195464016033	putative ligand binding residues [chemical binding]; other site
1195464016034	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1195464016035	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1195464016036	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1195464016037	DNA binding domain, excisionase family; Region: excise; TIGR01764
1195464016038	Sm and related proteins; Region: Sm_like; cl00259
1195464016039	heptamer interface [polypeptide binding]; other site
1195464016040	Sm1 motif; other site
1195464016041	hexamer interface [polypeptide binding]; other site
1195464016042	RNA binding site [nucleotide binding]; other site
1195464016043	Sm2 motif; other site
1195464016044	Sm and related proteins; Region: Sm_like; cl00259
1195464016045	Sm1 motif; other site
1195464016046	RNA binding site [nucleotide binding]; other site
1195464016047	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1195464016048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464016049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464016050	dimer interface [polypeptide binding]; other site
1195464016051	phosphorylation site [posttranslational modification]
1195464016052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016053	ATP binding site [chemical binding]; other site
1195464016054	Mg2+ binding site [ion binding]; other site
1195464016055	G-X-G motif; other site
1195464016056	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1195464016057	hypothetical protein; Provisional; Region: PRK06851
1195464016058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464016059	Walker A motif; other site
1195464016060	ATP binding site [chemical binding]; other site
1195464016061	NTPase; Region: NTPase_1; cl17478
1195464016062	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1195464016063	benzoate transport; Region: 2A0115; TIGR00895
1195464016064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016065	putative substrate translocation pore; other site
1195464016066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016067	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1195464016068	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1195464016069	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1195464016070	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1195464016071	[2Fe-2S] cluster binding site [ion binding]; other site
1195464016072	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1195464016073	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1195464016074	putative di-iron ligands [ion binding]; other site
1195464016075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464016076	dimer interface [polypeptide binding]; other site
1195464016077	conserved gate region; other site
1195464016078	putative PBP binding loops; other site
1195464016079	ABC-ATPase subunit interface; other site
1195464016080	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1195464016081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464016082	substrate binding pocket [chemical binding]; other site
1195464016083	membrane-bound complex binding site; other site
1195464016084	hinge residues; other site
1195464016085	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1195464016086	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1195464016087	Walker A/P-loop; other site
1195464016088	ATP binding site [chemical binding]; other site
1195464016089	Q-loop/lid; other site
1195464016090	ABC transporter signature motif; other site
1195464016091	Walker B; other site
1195464016092	D-loop; other site
1195464016093	H-loop/switch region; other site
1195464016094	HAMP domain; Region: HAMP; pfam00672
1195464016095	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464016096	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464016097	dimer interface [polypeptide binding]; other site
1195464016098	putative CheW interface [polypeptide binding]; other site
1195464016099	Arginine repressor [Transcription]; Region: ArgR; COG1438
1195464016100	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1195464016101	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1195464016102	arginine deiminase; Provisional; Region: PRK01388
1195464016103	ornithine carbamoyltransferase; Validated; Region: PRK02102
1195464016104	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1195464016105	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1195464016106	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1195464016107	carbamate kinase; Reviewed; Region: PRK12686
1195464016108	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1195464016109	putative substrate binding site [chemical binding]; other site
1195464016110	nucleotide binding site [chemical binding]; other site
1195464016111	nucleotide binding site [chemical binding]; other site
1195464016112	homodimer interface [polypeptide binding]; other site
1195464016113	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1195464016114	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1195464016115	ligand binding site [chemical binding]; other site
1195464016116	flexible hinge region; other site
1195464016117	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1195464016118	putative switch regulator; other site
1195464016119	non-specific DNA interactions [nucleotide binding]; other site
1195464016120	DNA binding site [nucleotide binding]
1195464016121	sequence specific DNA binding site [nucleotide binding]; other site
1195464016122	putative cAMP binding site [chemical binding]; other site
1195464016123	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1195464016124	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464016125	Berberine and berberine like; Region: BBE; pfam08031
1195464016126	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1195464016127	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1195464016128	Ca binding site [ion binding]; other site
1195464016129	active site
1195464016130	catalytic site [active]
1195464016131	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1195464016132	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
1195464016133	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1195464016134	active site turn [active]
1195464016135	phosphorylation site [posttranslational modification]
1195464016136	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
1195464016137	putative catalytic site [active]
1195464016138	putative metal binding site [ion binding]; other site
1195464016139	putative phosphate binding site [ion binding]; other site
1195464016140	Predicted membrane protein [Function unknown]; Region: COG1511
1195464016141	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1195464016142	Predicted membrane protein [Function unknown]; Region: COG1511
1195464016143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016144	DNA topoisomerase III; Provisional; Region: PRK07726
1195464016145	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1195464016146	active site
1195464016147	putative interdomain interaction site [polypeptide binding]; other site
1195464016148	putative metal-binding site [ion binding]; other site
1195464016149	putative nucleotide binding site [chemical binding]; other site
1195464016150	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1195464016151	domain I; other site
1195464016152	DNA binding groove [nucleotide binding]
1195464016153	phosphate binding site [ion binding]; other site
1195464016154	domain II; other site
1195464016155	domain III; other site
1195464016156	nucleotide binding site [chemical binding]; other site
1195464016157	catalytic site [active]
1195464016158	domain IV; other site
1195464016159	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1195464016160	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1195464016161	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1195464016162	substrate binding site [chemical binding]; other site
1195464016163	multimerization interface [polypeptide binding]; other site
1195464016164	ATP binding site [chemical binding]; other site
1195464016165	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1195464016166	thiamine phosphate binding site [chemical binding]; other site
1195464016167	active site
1195464016168	pyrophosphate binding site [ion binding]; other site
1195464016169	threonine dehydratase; Provisional; Region: PRK08198
1195464016170	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1195464016171	tetramer interface [polypeptide binding]; other site
1195464016172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464016173	catalytic residue [active]
1195464016174	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1195464016175	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1195464016176	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1195464016177	HAMP domain; Region: HAMP; pfam00672
1195464016178	dimerization interface [polypeptide binding]; other site
1195464016179	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464016180	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464016181	dimer interface [polypeptide binding]; other site
1195464016182	putative CheW interface [polypeptide binding]; other site
1195464016183	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1195464016184	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1195464016185	acyl-activating enzyme (AAE) consensus motif; other site
1195464016186	AMP binding site [chemical binding]; other site
1195464016187	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1195464016188	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1195464016189	putative NAD(P) binding site [chemical binding]; other site
1195464016190	active site
1195464016191	putative substrate binding site [chemical binding]; other site
1195464016192	Domain of unknown function DUF77; Region: DUF77; pfam01910
1195464016193	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1195464016194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464016195	dimer interface [polypeptide binding]; other site
1195464016196	conserved gate region; other site
1195464016197	putative PBP binding loops; other site
1195464016198	ABC-ATPase subunit interface; other site
1195464016199	NMT1/THI5 like; Region: NMT1; pfam09084
1195464016200	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1195464016201	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1195464016202	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1195464016203	Walker A/P-loop; other site
1195464016204	ATP binding site [chemical binding]; other site
1195464016205	Q-loop/lid; other site
1195464016206	ABC transporter signature motif; other site
1195464016207	Walker B; other site
1195464016208	D-loop; other site
1195464016209	H-loop/switch region; other site
1195464016210	Glyco_18 domain; Region: Glyco_18; smart00636
1195464016211	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1195464016212	active site
1195464016213	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1195464016214	Interdomain contacts; other site
1195464016215	Cytokine receptor motif; other site
1195464016216	Cellulose binding domain; Region: CBM_2; pfam00553
1195464016217	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1195464016218	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1195464016219	catalytic residues [active]
1195464016220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1195464016221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1195464016222	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1195464016223	H+ Antiporter protein; Region: 2A0121; TIGR00900
1195464016224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016225	putative substrate translocation pore; other site
1195464016226	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464016227	non-specific DNA binding site [nucleotide binding]; other site
1195464016228	salt bridge; other site
1195464016229	sequence-specific DNA binding site [nucleotide binding]; other site
1195464016230	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1195464016231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016232	putative substrate translocation pore; other site
1195464016233	Uncharacterized conserved protein [Function unknown]; Region: COG3379
1195464016234	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1195464016235	YesK-like protein; Region: YesK; pfam14150
1195464016236	prolyl-tRNA synthetase; Provisional; Region: PRK08661
1195464016237	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
1195464016238	dimer interface [polypeptide binding]; other site
1195464016239	motif 1; other site
1195464016240	active site
1195464016241	motif 2; other site
1195464016242	motif 3; other site
1195464016243	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
1195464016244	anticodon binding site; other site
1195464016245	zinc-binding site [ion binding]; other site
1195464016246	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016247	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016248	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016249	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016250	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016251	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016252	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016253	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464016254	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1195464016255	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1195464016256	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1195464016257	nucleotide binding site [chemical binding]; other site
1195464016258	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1195464016259	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1195464016260	putative metal binding site [ion binding]; other site
1195464016261	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1195464016262	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1195464016263	putative metal binding site [ion binding]; other site
1195464016264	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1195464016265	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1195464016266	putative metal binding site [ion binding]; other site
1195464016267	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1195464016268	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
1195464016269	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1195464016270	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1195464016271	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1195464016272	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464016273	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1195464016274	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1195464016275	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1195464016276	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
1195464016277	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1195464016278	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1195464016279	YtxH-like protein; Region: YtxH; cl02079
1195464016280	Domain of unknown function (DUF4075); Region: DUF4075; pfam13294
1195464016281	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1195464016282	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1195464016283	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464016284	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1195464016285	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1195464016286	EamA-like transporter family; Region: EamA; pfam00892
1195464016287	EamA-like transporter family; Region: EamA; pfam00892
1195464016288	YhhN-like protein; Region: YhhN; pfam07947
1195464016289	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1195464016290	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1195464016291	Catalytic site [active]
1195464016292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1195464016293	binding surface
1195464016294	TPR motif; other site
1195464016295	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1195464016296	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464016297	Predicted membrane protein [Function unknown]; Region: COG2510
1195464016298	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1195464016299	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1195464016300	calcium/proton exchanger (cax); Region: cax; TIGR00378
1195464016301	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1195464016302	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1195464016303	YfkD-like protein; Region: YfkD; pfam14167
1195464016304	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1195464016305	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464016306	FeS/SAM binding site; other site
1195464016307	YfkB-like domain; Region: YfkB; pfam08756
1195464016308	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1195464016309	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1195464016310	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1195464016311	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1195464016312	NodB motif; other site
1195464016313	active site
1195464016314	catalytic site [active]
1195464016315	Cd binding site [ion binding]; other site
1195464016316	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1195464016317	endonuclease III; Region: ENDO3c; smart00478
1195464016318	minor groove reading motif; other site
1195464016319	helix-hairpin-helix signature motif; other site
1195464016320	substrate binding pocket [chemical binding]; other site
1195464016321	active site
1195464016322	TRAM domain; Region: TRAM; pfam01938
1195464016323	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1195464016324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464016325	S-adenosylmethionine binding site [chemical binding]; other site
1195464016326	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1195464016327	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1195464016328	Int/Topo IB signature motif; other site
1195464016329	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1195464016330	Transcriptional regulator; Region: Transcrip_reg; cl00361
1195464016331	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464016332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464016333	non-specific DNA binding site [nucleotide binding]; other site
1195464016334	salt bridge; other site
1195464016335	sequence-specific DNA binding site [nucleotide binding]; other site
1195464016336	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464016337	salt bridge; other site
1195464016338	non-specific DNA binding site [nucleotide binding]; other site
1195464016339	sequence-specific DNA binding site [nucleotide binding]; other site
1195464016340	BRO family, N-terminal domain; Region: Bro-N; smart01040
1195464016341	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
1195464016342	Helix-turn-helix domain; Region: HTH_17; pfam12728
1195464016343	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
1195464016344	phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220
1195464016345	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1195464016346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464016347	Walker A motif; other site
1195464016348	ATP binding site [chemical binding]; other site
1195464016349	Walker B motif; other site
1195464016350	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
1195464016351	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1195464016352	YjcQ protein; Region: YjcQ; pfam09639
1195464016353	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464016354	non-specific DNA binding site [nucleotide binding]; other site
1195464016355	salt bridge; other site
1195464016356	sequence-specific DNA binding site [nucleotide binding]; other site
1195464016357	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1195464016358	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1195464016359	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1195464016360	Int/Topo IB signature motif; other site
1195464016361	Phage terminase, small subunit; Region: Terminase_4; cl01525
1195464016362	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1195464016363	Phage portal protein; Region: Phage_portal; pfam04860
1195464016364	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1195464016365	Clp protease; Region: CLP_protease; pfam00574
1195464016366	oligomer interface [polypeptide binding]; other site
1195464016367	active site residues [active]
1195464016368	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1195464016369	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1195464016370	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1195464016371	Phage-related minor tail protein [Function unknown]; Region: COG5280
1195464016372	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1195464016373	dimer interface [polypeptide binding]; other site
1195464016374	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1195464016375	Phage-related protein [Function unknown]; Region: COG4722
1195464016376	Phage tail protein; Region: Sipho_tail; pfam05709
1195464016377	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1195464016378	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
1195464016379	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
1195464016380	ADP-ribose binding site [chemical binding]; other site
1195464016381	Haemolysin XhlA; Region: XhlA; pfam10779
1195464016382	Haemolysin XhlA; Region: XhlA; pfam10779
1195464016383	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464016384	amidase catalytic site [active]
1195464016385	Zn binding residues [ion binding]; other site
1195464016386	substrate binding site [chemical binding]; other site
1195464016387	Bacterial SH3 domain; Region: SH3_3; cl17532
1195464016388	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
1195464016389	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1195464016390	dimerization interface 3.5A [polypeptide binding]; other site
1195464016391	active site
1195464016392	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1195464016393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464016394	Walker A motif; other site
1195464016395	ATP binding site [chemical binding]; other site
1195464016396	Walker B motif; other site
1195464016397	arginine finger; other site
1195464016398	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1195464016399	hypothetical protein; Validated; Region: PRK06748
1195464016400	S-methylmethionine transporter; Provisional; Region: PRK11387
1195464016401	acetylornithine deacetylase; Validated; Region: PRK08596
1195464016402	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1195464016403	metal binding site [ion binding]; metal-binding site
1195464016404	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464016405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464016406	non-specific DNA binding site [nucleotide binding]; other site
1195464016407	salt bridge; other site
1195464016408	sequence-specific DNA binding site [nucleotide binding]; other site
1195464016409	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
1195464016410	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1195464016411	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
1195464016412	glutaminase A; Region: Gln_ase; TIGR03814
1195464016413	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1195464016414	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1195464016415	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1195464016416	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1195464016417	active site turn [active]
1195464016418	phosphorylation site [posttranslational modification]
1195464016419	Beta-lactamase; Region: Beta-lactamase; pfam00144
1195464016420	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1195464016421	Sm and related proteins; Region: Sm_like; cl00259
1195464016422	heptamer interface [polypeptide binding]; other site
1195464016423	Sm1 motif; other site
1195464016424	hexamer interface [polypeptide binding]; other site
1195464016425	RNA binding site [nucleotide binding]; other site
1195464016426	Sm2 motif; other site
1195464016427	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1195464016428	active site
1195464016429	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464016430	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1195464016431	active site
1195464016432	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
1195464016433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464016434	NAD(P) binding site [chemical binding]; other site
1195464016435	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1195464016436	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1195464016437	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464016438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1195464016439	NAD(P) binding site [chemical binding]; other site
1195464016440	active site
1195464016441	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464016442	active site
1195464016443	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1195464016444	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1195464016445	active site
1195464016446	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1195464016447	Pyruvate formate lyase 1; Region: PFL1; cd01678
1195464016448	coenzyme A binding site [chemical binding]; other site
1195464016449	active site
1195464016450	catalytic residues [active]
1195464016451	glycine loop; other site
1195464016452	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1195464016453	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1195464016454	FeS/SAM binding site; other site
1195464016455	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1195464016456	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1195464016457	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1195464016458	YfhE-like protein; Region: YfhE; pfam14152
1195464016459	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1195464016460	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1195464016461	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
1195464016462	active site
1195464016463	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1195464016464	TIGR01777 family protein; Region: yfcH
1195464016465	putative NAD(P) binding site [chemical binding]; other site
1195464016466	putative active site [active]
1195464016467	recombination regulator RecX; Provisional; Region: recX; PRK14135
1195464016468	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1195464016469	acid-soluble spore protein K; Provisional; Region: sspK; PRK03081
1195464016470	WVELL protein; Region: WVELL; pfam14043
1195464016471	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1195464016472	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1195464016473	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1195464016474	minor groove reading motif; other site
1195464016475	helix-hairpin-helix signature motif; other site
1195464016476	substrate binding pocket [chemical binding]; other site
1195464016477	active site
1195464016478	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1195464016479	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1195464016480	DNA binding and oxoG recognition site [nucleotide binding]
1195464016481	YgaB-like protein; Region: YgaB; pfam14182
1195464016482	hypothetical protein; Provisional; Region: PRK13662
1195464016483	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1195464016484	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1195464016485	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1195464016486	Walker A/P-loop; other site
1195464016487	ATP binding site [chemical binding]; other site
1195464016488	Q-loop/lid; other site
1195464016489	ABC transporter signature motif; other site
1195464016490	Walker B; other site
1195464016491	D-loop; other site
1195464016492	H-loop/switch region; other site
1195464016493	Predicted membrane protein [Function unknown]; Region: COG4129
1195464016494	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1195464016495	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1195464016496	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1195464016497	active site
1195464016498	dimer interface [polypeptide binding]; other site
1195464016499	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1195464016500	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1195464016501	active site
1195464016502	FMN binding site [chemical binding]; other site
1195464016503	substrate binding site [chemical binding]; other site
1195464016504	3Fe-4S cluster binding site [ion binding]; other site
1195464016505	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
1195464016506	domain_subunit interface; other site
1195464016507	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1195464016508	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1195464016509	inhibitor-cofactor binding pocket; inhibition site
1195464016510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464016511	catalytic residue [active]
1195464016512	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1195464016513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464016514	Walker A/P-loop; other site
1195464016515	ATP binding site [chemical binding]; other site
1195464016516	Q-loop/lid; other site
1195464016517	ABC transporter signature motif; other site
1195464016518	Walker B; other site
1195464016519	D-loop; other site
1195464016520	H-loop/switch region; other site
1195464016521	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1195464016522	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1195464016523	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1195464016524	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1195464016525	Ion channel; Region: Ion_trans_2; pfam07885
1195464016526	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1195464016527	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1195464016528	catalytic triad [active]
1195464016529	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1195464016530	metal binding site 2 [ion binding]; metal-binding site
1195464016531	putative DNA binding helix; other site
1195464016532	metal binding site 1 [ion binding]; metal-binding site
1195464016533	dimer interface [polypeptide binding]; other site
1195464016534	structural Zn2+ binding site [ion binding]; other site
1195464016535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464016536	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1195464016537	Coenzyme A binding pocket [chemical binding]; other site
1195464016538	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
1195464016539	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
1195464016540	hypothetical protein; Provisional; Region: PRK12378
1195464016541	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1195464016542	nudix motif; other site
1195464016543	Transglycosylase; Region: Transgly; pfam00912
1195464016544	Thioredoxin; Region: Thioredoxin_4; pfam13462
1195464016545	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1195464016546	epoxyqueuosine reductase; Region: TIGR00276
1195464016547	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1195464016548	Putative amidase domain; Region: Amidase_6; pfam12671
1195464016549	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1195464016550	PAS fold; Region: PAS_4; pfam08448
1195464016551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1195464016552	putative active site [active]
1195464016553	heme pocket [chemical binding]; other site
1195464016554	PAS domain; Region: PAS_9; pfam13426
1195464016555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464016556	putative active site [active]
1195464016557	heme pocket [chemical binding]; other site
1195464016558	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1195464016559	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464016560	metal binding site [ion binding]; metal-binding site
1195464016561	active site
1195464016562	I-site; other site
1195464016563	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464016564	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1195464016565	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1195464016566	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
1195464016567	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
1195464016568	heme-binding site [chemical binding]; other site
1195464016569	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016570	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016571	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016572	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016573	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016574	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016575	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016576	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1195464016577	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1195464016578	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1195464016579	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1195464016580	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1195464016581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1195464016582	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1195464016583	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1195464016584	Cache domain; Region: Cache_1; pfam02743
1195464016585	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464016586	dimerization interface [polypeptide binding]; other site
1195464016587	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464016588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464016589	dimer interface [polypeptide binding]; other site
1195464016590	putative CheW interface [polypeptide binding]; other site
1195464016591	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1195464016592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1195464016593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016594	ATP binding site [chemical binding]; other site
1195464016595	Mg2+ binding site [ion binding]; other site
1195464016596	G-X-G motif; other site
1195464016597	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1195464016598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464016599	active site
1195464016600	phosphorylation site [posttranslational modification]
1195464016601	intermolecular recognition site; other site
1195464016602	dimerization interface [polypeptide binding]; other site
1195464016603	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1195464016604	Citrate transporter; Region: CitMHS; pfam03600
1195464016605	hypothetical protein; Provisional; Region: PRK12784
1195464016606	NosL; Region: NosL; cl01769
1195464016607	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1195464016608	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1195464016609	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1195464016610	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1195464016611	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
1195464016612	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1195464016613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1195464016614	Walker A/P-loop; other site
1195464016615	ATP binding site [chemical binding]; other site
1195464016616	Q-loop/lid; other site
1195464016617	ABC transporter signature motif; other site
1195464016618	Walker B; other site
1195464016619	D-loop; other site
1195464016620	H-loop/switch region; other site
1195464016621	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1195464016622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464016623	dimer interface [polypeptide binding]; other site
1195464016624	conserved gate region; other site
1195464016625	putative PBP binding loops; other site
1195464016626	ABC-ATPase subunit interface; other site
1195464016627	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1195464016628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464016629	dimer interface [polypeptide binding]; other site
1195464016630	conserved gate region; other site
1195464016631	putative PBP binding loops; other site
1195464016632	ABC-ATPase subunit interface; other site
1195464016633	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1195464016634	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1195464016635	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1195464016636	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1195464016637	active site
1195464016638	metal binding site [ion binding]; metal-binding site
1195464016639	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464016640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464016641	active site
1195464016642	phosphorylation site [posttranslational modification]
1195464016643	intermolecular recognition site; other site
1195464016644	dimerization interface [polypeptide binding]; other site
1195464016645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464016646	DNA binding site [nucleotide binding]
1195464016647	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464016648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464016649	dimer interface [polypeptide binding]; other site
1195464016650	phosphorylation site [posttranslational modification]
1195464016651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016652	ATP binding site [chemical binding]; other site
1195464016653	Mg2+ binding site [ion binding]; other site
1195464016654	G-X-G motif; other site
1195464016655	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1195464016656	putative active site [active]
1195464016657	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1195464016658	Cache domain; Region: Cache_1; pfam02743
1195464016659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464016660	dimerization interface [polypeptide binding]; other site
1195464016661	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464016662	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464016663	dimer interface [polypeptide binding]; other site
1195464016664	putative CheW interface [polypeptide binding]; other site
1195464016665	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1195464016666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016667	ATP binding site [chemical binding]; other site
1195464016668	Mg2+ binding site [ion binding]; other site
1195464016669	G-X-G motif; other site
1195464016670	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1195464016671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464016672	active site
1195464016673	phosphorylation site [posttranslational modification]
1195464016674	intermolecular recognition site; other site
1195464016675	dimerization interface [polypeptide binding]; other site
1195464016676	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1195464016677	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1195464016678	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1195464016679	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1195464016680	putative NAD(P) binding site [chemical binding]; other site
1195464016681	EamA-like transporter family; Region: EamA; pfam00892
1195464016682	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1195464016683	EamA-like transporter family; Region: EamA; pfam00892
1195464016684	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1195464016685	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1195464016686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464016687	homodimer interface [polypeptide binding]; other site
1195464016688	catalytic residue [active]
1195464016689	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1195464016690	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464016691	Coenzyme A binding pocket [chemical binding]; other site
1195464016692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464016693	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464016694	dimerization interface [polypeptide binding]; other site
1195464016695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464016696	dimer interface [polypeptide binding]; other site
1195464016697	phosphorylation site [posttranslational modification]
1195464016698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016699	ATP binding site [chemical binding]; other site
1195464016700	Mg2+ binding site [ion binding]; other site
1195464016701	G-X-G motif; other site
1195464016702	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464016703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464016704	active site
1195464016705	phosphorylation site [posttranslational modification]
1195464016706	intermolecular recognition site; other site
1195464016707	dimerization interface [polypeptide binding]; other site
1195464016708	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464016709	DNA binding site [nucleotide binding]
1195464016710	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1195464016711	Arrestin_N terminal like; Region: LDB19; pfam13002
1195464016712	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1195464016713	Coenzyme A binding pocket [chemical binding]; other site
1195464016714	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1195464016715	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1195464016716	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1195464016717	catalytic loop [active]
1195464016718	iron binding site [ion binding]; other site
1195464016719	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1195464016720	4Fe-4S binding domain; Region: Fer4; pfam00037
1195464016721	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1195464016722	[4Fe-4S] binding site [ion binding]; other site
1195464016723	molybdopterin cofactor binding site; other site
1195464016724	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1195464016725	molybdopterin cofactor binding site; other site
1195464016726	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1195464016727	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
1195464016728	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1195464016729	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1195464016730	putative active site [active]
1195464016731	catalytic site [active]
1195464016732	putative metal binding site [ion binding]; other site
1195464016733	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1195464016734	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1195464016735	hexamer interface [polypeptide binding]; other site
1195464016736	ligand binding site [chemical binding]; other site
1195464016737	putative active site [active]
1195464016738	NAD(P) binding site [chemical binding]; other site
1195464016739	amino acid transporter; Region: 2A0306; TIGR00909
1195464016740	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1195464016741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1195464016742	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464016743	dimerization interface [polypeptide binding]; other site
1195464016744	putative DNA binding site [nucleotide binding]; other site
1195464016745	putative Zn2+ binding site [ion binding]; other site
1195464016746	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1195464016747	metal-binding site [ion binding]
1195464016748	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1195464016749	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1195464016750	metal-binding site [ion binding]
1195464016751	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1195464016752	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1195464016753	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1195464016754	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1195464016755	active site
1195464016756	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464016757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464016758	non-specific DNA binding site [nucleotide binding]; other site
1195464016759	salt bridge; other site
1195464016760	sequence-specific DNA binding site [nucleotide binding]; other site
1195464016761	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1195464016762	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1195464016763	binding surface
1195464016764	TPR motif; other site
1195464016765	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1195464016766	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1195464016767	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1195464016768	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1195464016769	active site
1195464016770	Zn binding site [ion binding]; other site
1195464016771	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1195464016772	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1195464016773	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1195464016774	VanW like protein; Region: VanW; pfam04294
1195464016775	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1195464016776	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1195464016777	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1195464016778	Nucleoside recognition; Region: Gate; pfam07670
1195464016779	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1195464016780	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1195464016781	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1195464016782	putative metal binding site [ion binding]; other site
1195464016783	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1195464016784	Domain of unknown function DUF21; Region: DUF21; pfam01595
1195464016785	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1195464016786	Transporter associated domain; Region: CorC_HlyC; smart01091
1195464016787	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1195464016788	Aspartase; Region: Aspartase; cd01357
1195464016789	active sites [active]
1195464016790	tetramer interface [polypeptide binding]; other site
1195464016791	L-lactate permease; Region: Lactate_perm; cl00701
1195464016792	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1195464016793	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1195464016794	dimerization interface [polypeptide binding]; other site
1195464016795	putative Zn2+ binding site [ion binding]; other site
1195464016796	putative DNA binding site [nucleotide binding]; other site
1195464016797	acid-soluble spore protein H; Provisional; Region: sspH; PRK01625
1195464016798	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1195464016799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016800	putative substrate translocation pore; other site
1195464016801	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1195464016802	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1195464016803	siderophore binding site; other site
1195464016804	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464016805	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464016806	ABC-ATPase subunit  interface; other site
1195464016807	dimer interface [polypeptide binding]; other site
1195464016808	putative PBP binding regions; other site
1195464016809	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1195464016810	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1195464016811	ABC-ATPase subunit  interface; other site
1195464016812	dimer interface [polypeptide binding]; other site
1195464016813	putative PBP binding regions; other site
1195464016814	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1195464016815	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1195464016816	Walker A/P-loop; other site
1195464016817	ATP binding site [chemical binding]; other site
1195464016818	Q-loop/lid; other site
1195464016819	ABC transporter signature motif; other site
1195464016820	Walker B; other site
1195464016821	D-loop; other site
1195464016822	H-loop/switch region; other site
1195464016823	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1195464016824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1195464016825	S-adenosylmethionine binding site [chemical binding]; other site
1195464016826	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1195464016827	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1195464016828	substrate-cofactor binding pocket; other site
1195464016829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1195464016830	catalytic residue [active]
1195464016831	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1195464016832	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
1195464016833	NAD binding site [chemical binding]; other site
1195464016834	homodimer interface [polypeptide binding]; other site
1195464016835	active site
1195464016836	putative substrate binding site [chemical binding]; other site
1195464016837	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1195464016838	nudix motif; other site
1195464016839	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1195464016840	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1195464016841	metal ion-dependent adhesion site (MIDAS); other site
1195464016842	MoxR-like ATPases [General function prediction only]; Region: COG0714
1195464016843	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1195464016844	Walker A motif; other site
1195464016845	ATP binding site [chemical binding]; other site
1195464016846	Walker B motif; other site
1195464016847	arginine finger; other site
1195464016848	cardiolipin synthetase; Reviewed; Region: PRK12452
1195464016849	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1195464016850	putative active site [active]
1195464016851	catalytic site [active]
1195464016852	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1195464016853	putative active site [active]
1195464016854	catalytic site [active]
1195464016855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1195464016856	PAS domain; Region: PAS_9; pfam13426
1195464016857	putative active site [active]
1195464016858	heme pocket [chemical binding]; other site
1195464016859	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1195464016860	metal binding site [ion binding]; metal-binding site
1195464016861	active site
1195464016862	I-site; other site
1195464016863	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1195464016864	putrescine transporter; Provisional; Region: potE; PRK10655
1195464016865	Spore germination protein; Region: Spore_permease; cl17796
1195464016866	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1195464016867	DNA-binding site [nucleotide binding]; DNA binding site
1195464016868	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1195464016869	UTRA domain; Region: UTRA; pfam07702
1195464016870	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1195464016871	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1195464016872	active site turn [active]
1195464016873	phosphorylation site [posttranslational modification]
1195464016874	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1195464016875	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1195464016876	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1195464016877	Ca binding site [ion binding]; other site
1195464016878	active site
1195464016879	catalytic site [active]
1195464016880	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464016881	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464016882	Spore germination protein; Region: Spore_permease; cl17796
1195464016883	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464016884	GAF domain; Region: GAF_3; pfam13492
1195464016885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1195464016886	Histidine kinase; Region: HisKA_3; pfam07730
1195464016887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016888	ATP binding site [chemical binding]; other site
1195464016889	Mg2+ binding site [ion binding]; other site
1195464016890	G-X-G motif; other site
1195464016891	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1195464016892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464016893	active site
1195464016894	phosphorylation site [posttranslational modification]
1195464016895	intermolecular recognition site; other site
1195464016896	dimerization interface [polypeptide binding]; other site
1195464016897	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1195464016898	DNA binding residues [nucleotide binding]
1195464016899	dimerization interface [polypeptide binding]; other site
1195464016900	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1195464016901	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1195464016902	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1195464016903	putative active site [active]
1195464016904	catalytic triad [active]
1195464016905	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1195464016906	PA/protease domain interface [polypeptide binding]; other site
1195464016907	putative integrin binding motif; other site
1195464016908	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1195464016909	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1195464016910	dockerin binding interface; other site
1195464016911	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1195464016912	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1195464016913	active site
1195464016914	ATP binding site [chemical binding]; other site
1195464016915	substrate binding site [chemical binding]; other site
1195464016916	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1195464016917	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1195464016918	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1195464016919	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1195464016920	Walker A/P-loop; other site
1195464016921	ATP binding site [chemical binding]; other site
1195464016922	Q-loop/lid; other site
1195464016923	ABC transporter signature motif; other site
1195464016924	Walker B; other site
1195464016925	D-loop; other site
1195464016926	H-loop/switch region; other site
1195464016927	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1195464016928	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1195464016929	substrate binding pocket [chemical binding]; other site
1195464016930	membrane-bound complex binding site; other site
1195464016931	hinge residues; other site
1195464016932	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1195464016933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464016934	dimer interface [polypeptide binding]; other site
1195464016935	conserved gate region; other site
1195464016936	putative PBP binding loops; other site
1195464016937	ABC-ATPase subunit interface; other site
1195464016938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464016939	dimer interface [polypeptide binding]; other site
1195464016940	conserved gate region; other site
1195464016941	putative PBP binding loops; other site
1195464016942	ABC-ATPase subunit interface; other site
1195464016943	S-methylmethionine transporter; Provisional; Region: PRK11387
1195464016944	OsmC-like protein; Region: OsmC; pfam02566
1195464016945	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1195464016946	nucleotide binding site/active site [active]
1195464016947	HIT family signature motif; other site
1195464016948	catalytic residue [active]
1195464016949	RNA polymerase sigma factor; Provisional; Region: PRK12542
1195464016950	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1195464016951	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464016952	DNA binding residues [nucleotide binding]
1195464016953	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
1195464016954	Predicted transcriptional regulator [Transcription]; Region: COG2378
1195464016955	HTH domain; Region: HTH_11; pfam08279
1195464016956	WYL domain; Region: WYL; pfam13280
1195464016957	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1195464016958	RibD C-terminal domain; Region: RibD_C; cl17279
1195464016959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1195464016960	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1195464016961	dimerization interface [polypeptide binding]; other site
1195464016962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1195464016963	dimer interface [polypeptide binding]; other site
1195464016964	phosphorylation site [posttranslational modification]
1195464016965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1195464016966	ATP binding site [chemical binding]; other site
1195464016967	Mg2+ binding site [ion binding]; other site
1195464016968	G-X-G motif; other site
1195464016969	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1195464016970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1195464016971	active site
1195464016972	phosphorylation site [posttranslational modification]
1195464016973	intermolecular recognition site; other site
1195464016974	dimerization interface [polypeptide binding]; other site
1195464016975	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1195464016976	DNA binding site [nucleotide binding]
1195464016977	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1195464016978	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1195464016979	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1195464016980	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1195464016981	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1195464016982	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1195464016983	Ligand Binding Site [chemical binding]; other site
1195464016984	Protein of unknown function (DUF4027); Region: DUF4027; pfam13219
1195464016985	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1195464016986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016987	putative substrate translocation pore; other site
1195464016988	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1195464016989	MarR family; Region: MarR; pfam01047
1195464016990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464016991	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464016992	putative substrate translocation pore; other site
1195464016993	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1195464016994	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1195464016995	DNA binding site [nucleotide binding]
1195464016996	domain linker motif; other site
1195464016997	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1195464016998	dimerization interface [polypeptide binding]; other site
1195464016999	ligand binding site [chemical binding]; other site
1195464017000	sodium binding site [ion binding]; other site
1195464017001	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1195464017002	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1195464017003	substrate binding site [chemical binding]; other site
1195464017004	dimer interface [polypeptide binding]; other site
1195464017005	ATP binding site [chemical binding]; other site
1195464017006	D-ribose pyranase; Provisional; Region: PRK11797
1195464017007	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1195464017008	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1195464017009	Walker A/P-loop; other site
1195464017010	ATP binding site [chemical binding]; other site
1195464017011	Q-loop/lid; other site
1195464017012	ABC transporter signature motif; other site
1195464017013	Walker B; other site
1195464017014	D-loop; other site
1195464017015	H-loop/switch region; other site
1195464017016	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1195464017017	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1195464017018	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1195464017019	TM-ABC transporter signature motif; other site
1195464017020	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1195464017021	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1195464017022	ligand binding site [chemical binding]; other site
1195464017023	dimerization interface [polypeptide binding]; other site
1195464017024	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1195464017025	active site
1195464017026	intersubunit interactions; other site
1195464017027	catalytic residue [active]
1195464017028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1195464017029	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
1195464017030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464017031	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1195464017032	putative substrate translocation pore; other site
1195464017033	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1195464017034	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1195464017035	putative NAD(P) binding site [chemical binding]; other site
1195464017036	catalytic Zn binding site [ion binding]; other site
1195464017037	Ion channel; Region: Ion_trans_2; pfam07885
1195464017038	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
1195464017039	Zn binding site [ion binding]; other site
1195464017040	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1195464017041	putative catalytic site [active]
1195464017042	metal binding site A [ion binding]; metal-binding site
1195464017043	phosphate binding site [ion binding]; other site
1195464017044	metal binding site C [ion binding]; metal-binding site
1195464017045	metal binding site B [ion binding]; metal-binding site
1195464017046	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
1195464017047	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1195464017048	dimer interface [polypeptide binding]; other site
1195464017049	active site
1195464017050	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1195464017051	substrate binding site [chemical binding]; other site
1195464017052	catalytic residue [active]
1195464017053	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1195464017054	FAD binding domain; Region: FAD_binding_4; pfam01565
1195464017055	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1195464017056	VanZ like family; Region: VanZ; pfam04892
1195464017057	RDD family; Region: RDD; pfam06271
1195464017058	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1195464017059	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1195464017060	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1195464017061	dimer interface [polypeptide binding]; other site
1195464017062	putative CheW interface [polypeptide binding]; other site
1195464017063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1195464017064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1195464017065	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464017066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464017067	non-specific DNA binding site [nucleotide binding]; other site
1195464017068	salt bridge; other site
1195464017069	sequence-specific DNA binding site [nucleotide binding]; other site
1195464017070	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1195464017071	active site
1195464017072	catalytic site [active]
1195464017073	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1195464017074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1195464017075	putative substrate translocation pore; other site
1195464017076	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1195464017077	Tropomyosin like; Region: Tropomyosin_1; pfam12718
1195464017078	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1195464017079	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1195464017080	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1195464017081	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1195464017082	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1195464017083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464017084	non-specific DNA binding site [nucleotide binding]; other site
1195464017085	salt bridge; other site
1195464017086	sequence-specific DNA binding site [nucleotide binding]; other site
1195464017087	Protein of unknown function (DUF4022); Region: DUF4022; pfam13214
1195464017088	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1195464017089	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1195464017090	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1195464017091	TrkA-N domain; Region: TrkA_N; pfam02254
1195464017092	TrkA-C domain; Region: TrkA_C; pfam02080
1195464017093	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
1195464017094	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
1195464017095	Subunit I/III interface [polypeptide binding]; other site
1195464017096	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1195464017097	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1195464017098	D-pathway; other site
1195464017099	Putative ubiquinol binding site [chemical binding]; other site
1195464017100	Low-spin heme (heme b) binding site [chemical binding]; other site
1195464017101	Putative water exit pathway; other site
1195464017102	Binuclear center (heme o3/CuB) [ion binding]; other site
1195464017103	K-pathway; other site
1195464017104	Putative proton exit pathway; other site
1195464017105	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
1195464017106	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1195464017107	S-methylmethionine transporter; Provisional; Region: PRK11387
1195464017108	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1195464017109	putative active site [active]
1195464017110	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1195464017111	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1195464017112	metal binding site [ion binding]; metal-binding site
1195464017113	dimer interface [polypeptide binding]; other site
1195464017114	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1195464017115	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1195464017116	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1195464017117	Na binding site [ion binding]; other site
1195464017118	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1195464017119	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
1195464017120	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1195464017121	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1195464017122	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1195464017123	Nucleoside recognition; Region: Gate; pfam07670
1195464017124	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1195464017125	Nucleoside recognition; Region: Gate; pfam07670
1195464017126	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
1195464017127	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1195464017128	G1 box; other site
1195464017129	GTP/Mg2+ binding site [chemical binding]; other site
1195464017130	Switch I region; other site
1195464017131	G2 box; other site
1195464017132	G3 box; other site
1195464017133	Switch II region; other site
1195464017134	G4 box; other site
1195464017135	G5 box; other site
1195464017136	FeoA domain; Region: FeoA; pfam04023
1195464017137	phosphate binding protein; Region: ptsS_2; TIGR02136
1195464017138	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1195464017139	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1195464017140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464017141	dimer interface [polypeptide binding]; other site
1195464017142	conserved gate region; other site
1195464017143	putative PBP binding loops; other site
1195464017144	ABC-ATPase subunit interface; other site
1195464017145	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1195464017146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1195464017147	dimer interface [polypeptide binding]; other site
1195464017148	conserved gate region; other site
1195464017149	putative PBP binding loops; other site
1195464017150	ABC-ATPase subunit interface; other site
1195464017151	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1195464017152	Protein export membrane protein; Region: SecD_SecF; cl14618
1195464017153	Protein export membrane protein; Region: SecD_SecF; cl14618
1195464017154	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1195464017155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1195464017156	Phage capsid family; Region: Phage_capsid; pfam05065
1195464017157	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1195464017158	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
1195464017159	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
1195464017160	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
1195464017161	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1195464017162	Holin family; Region: Phage_holin_4; cl01989
1195464017163	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1195464017164	amidase catalytic site [active]
1195464017165	Zn binding residues [ion binding]; other site
1195464017166	substrate binding site [chemical binding]; other site
1195464017167	Bacterial SH3 domain; Region: SH3_3; pfam08239
1195464017168	Helix-turn-helix domain; Region: HTH_17; cl17695
1195464017169	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
1195464017170	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1195464017171	nucleotide binding site [chemical binding]; other site
1195464017172	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1195464017173	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1195464017174	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
1195464017175	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464017176	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464017177	non-specific DNA binding site [nucleotide binding]; other site
1195464017178	salt bridge; other site
1195464017179	sequence-specific DNA binding site [nucleotide binding]; other site
1195464017180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464017181	non-specific DNA binding site [nucleotide binding]; other site
1195464017182	salt bridge; other site
1195464017183	sequence-specific DNA binding site [nucleotide binding]; other site
1195464017184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1195464017185	salt bridge; other site
1195464017186	non-specific DNA binding site [nucleotide binding]; other site
1195464017187	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1195464017188	sequence-specific DNA binding site [nucleotide binding]; other site
1195464017189	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
1195464017190	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1195464017191	ORF6C domain; Region: ORF6C; pfam10552
1195464017192	hypothetical protein; Provisional; Region: PRK09866
1195464017193	dUTPase; Region: dUTPase_2; pfam08761
1195464017194	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1195464017195	active site
1195464017196	homodimer interface [polypeptide binding]; other site
1195464017197	metal binding site [ion binding]; metal-binding site
1195464017198	Recombination protein U; Region: RecU; pfam03838
1195464017199	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
1195464017200	positive control sigma-like factor; Validated; Region: PRK06930
1195464017201	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1195464017202	DNA binding residues [nucleotide binding]
1195464017203	Helix-turn-helix domain; Region: HTH_17; cl17695
1195464017204	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1195464017205	Int/Topo IB signature motif; other site
1195464017206	Uncharacterized conserved protein [Function unknown]; Region: COG5484
1195464017207	Phage terminase small subunit; Region: Phage_terminase; pfam10668
1195464017208	Phage terminase large subunit; Region: Terminase_3; cl12054
1195464017209	Terminase-like family; Region: Terminase_6; pfam03237
1195464017210	Phage-related protein [Function unknown]; Region: COG4695; cl01923