-- dump date 20140618_235556 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1286404000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1286404000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1286404000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404000004 Walker A motif; other site 1286404000005 ATP binding site [chemical binding]; other site 1286404000006 Walker B motif; other site 1286404000007 arginine finger; other site 1286404000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1286404000009 DnaA box-binding interface [nucleotide binding]; other site 1286404000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1286404000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1286404000012 putative DNA binding surface [nucleotide binding]; other site 1286404000013 dimer interface [polypeptide binding]; other site 1286404000014 beta-clamp/clamp loader binding surface; other site 1286404000015 beta-clamp/translesion DNA polymerase binding surface; other site 1286404000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1286404000017 recombination protein F; Reviewed; Region: recF; PRK00064 1286404000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1286404000019 Walker A/P-loop; other site 1286404000020 ATP binding site [chemical binding]; other site 1286404000021 Q-loop/lid; other site 1286404000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404000023 ABC transporter signature motif; other site 1286404000024 Walker B; other site 1286404000025 D-loop; other site 1286404000026 H-loop/switch region; other site 1286404000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1286404000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404000029 Mg2+ binding site [ion binding]; other site 1286404000030 G-X-G motif; other site 1286404000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1286404000032 anchoring element; other site 1286404000033 dimer interface [polypeptide binding]; other site 1286404000034 ATP binding site [chemical binding]; other site 1286404000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1286404000036 active site 1286404000037 putative metal-binding site [ion binding]; other site 1286404000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1286404000039 DNA gyrase subunit A; Validated; Region: PRK05560 1286404000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1286404000041 CAP-like domain; other site 1286404000042 active site 1286404000043 primary dimer interface [polypeptide binding]; other site 1286404000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404000050 YaaC-like Protein; Region: YaaC; pfam14175 1286404000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1286404000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286404000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1286404000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1286404000055 active site 1286404000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286404000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1286404000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1286404000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1286404000061 active site 1286404000062 multimer interface [polypeptide binding]; other site 1286404000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1286404000064 predicted active site [active] 1286404000065 catalytic triad [active] 1286404000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 1286404000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1286404000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1286404000069 dimer interface [polypeptide binding]; other site 1286404000070 active site 1286404000071 motif 1; other site 1286404000072 motif 2; other site 1286404000073 motif 3; other site 1286404000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 1286404000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404000076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1286404000077 DNA binding residues [nucleotide binding] 1286404000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1286404000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1286404000080 Substrate-binding site [chemical binding]; other site 1286404000081 Substrate specificity [chemical binding]; other site 1286404000082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1286404000083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1286404000084 Substrate-binding site [chemical binding]; other site 1286404000085 Substrate specificity [chemical binding]; other site 1286404000086 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404000087 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286404000088 catalytic triad [active] 1286404000089 conserved cis-peptide bond; other site 1286404000090 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1286404000091 nucleoside/Zn binding site; other site 1286404000092 dimer interface [polypeptide binding]; other site 1286404000093 catalytic motif [active] 1286404000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1286404000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404000096 Walker A motif; other site 1286404000097 ATP binding site [chemical binding]; other site 1286404000098 Walker B motif; other site 1286404000099 arginine finger; other site 1286404000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1286404000101 hypothetical protein; Validated; Region: PRK00153 1286404000102 recombination protein RecR; Reviewed; Region: recR; PRK00076 1286404000103 RecR protein; Region: RecR; pfam02132 1286404000104 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1286404000105 putative active site [active] 1286404000106 putative metal-binding site [ion binding]; other site 1286404000107 tetramer interface [polypeptide binding]; other site 1286404000108 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1286404000109 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1286404000110 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1286404000111 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1286404000112 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1286404000113 homodimer interface [polypeptide binding]; other site 1286404000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404000115 catalytic residue [active] 1286404000116 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286404000117 thymidylate kinase; Validated; Region: tmk; PRK00698 1286404000118 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1286404000119 TMP-binding site; other site 1286404000120 ATP-binding site [chemical binding]; other site 1286404000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1286404000122 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1286404000123 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1286404000124 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1286404000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404000126 S-adenosylmethionine binding site [chemical binding]; other site 1286404000127 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1286404000128 putative active site [active] 1286404000129 GIY-YIG motif/motif A; other site 1286404000130 putative metal binding site [ion binding]; other site 1286404000131 Predicted methyltransferases [General function prediction only]; Region: COG0313 1286404000132 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1286404000133 putative SAM binding site [chemical binding]; other site 1286404000134 putative homodimer interface [polypeptide binding]; other site 1286404000135 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286404000136 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404000137 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1286404000138 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1286404000139 active site 1286404000140 HIGH motif; other site 1286404000141 KMSKS motif; other site 1286404000142 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1286404000143 tRNA binding surface [nucleotide binding]; other site 1286404000144 anticodon binding site; other site 1286404000145 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1286404000146 dimer interface [polypeptide binding]; other site 1286404000147 putative tRNA-binding site [nucleotide binding]; other site 1286404000148 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1286404000149 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1286404000150 active site 1286404000151 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1286404000152 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1286404000153 putative active site [active] 1286404000154 putative metal binding site [ion binding]; other site 1286404000155 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1286404000156 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1286404000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404000158 S-adenosylmethionine binding site [chemical binding]; other site 1286404000159 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1286404000160 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1286404000161 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404000162 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1286404000163 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1286404000164 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1286404000165 pur operon repressor; Provisional; Region: PRK09213 1286404000166 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1286404000167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404000168 active site 1286404000169 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286404000170 homotrimer interaction site [polypeptide binding]; other site 1286404000171 putative active site [active] 1286404000172 regulatory protein SpoVG; Reviewed; Region: PRK13259 1286404000173 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1286404000174 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1286404000175 Substrate binding site; other site 1286404000176 Mg++ binding site; other site 1286404000177 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1286404000178 active site 1286404000179 substrate binding site [chemical binding]; other site 1286404000180 CoA binding site [chemical binding]; other site 1286404000181 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1286404000182 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1286404000183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404000184 active site 1286404000185 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1286404000186 putative active site [active] 1286404000187 catalytic residue [active] 1286404000188 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1286404000189 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1286404000190 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1286404000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404000192 ATP binding site [chemical binding]; other site 1286404000193 putative Mg++ binding site [ion binding]; other site 1286404000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404000195 nucleotide binding region [chemical binding]; other site 1286404000196 ATP-binding site [chemical binding]; other site 1286404000197 TRCF domain; Region: TRCF; pfam03461 1286404000198 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1286404000199 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1286404000200 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1286404000201 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1286404000202 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1286404000203 putative SAM binding site [chemical binding]; other site 1286404000204 putative homodimer interface [polypeptide binding]; other site 1286404000205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1286404000206 homodimer interface [polypeptide binding]; other site 1286404000207 metal binding site [ion binding]; metal-binding site 1286404000208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1286404000209 homodimer interface [polypeptide binding]; other site 1286404000210 active site 1286404000211 putative chemical substrate binding site [chemical binding]; other site 1286404000212 metal binding site [ion binding]; metal-binding site 1286404000213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404000214 RNA binding surface [nucleotide binding]; other site 1286404000215 sporulation protein YabP; Region: spore_yabP; TIGR02892 1286404000216 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1286404000217 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1286404000218 Septum formation initiator; Region: DivIC; pfam04977 1286404000219 hypothetical protein; Provisional; Region: PRK08582 1286404000220 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1286404000221 RNA binding site [nucleotide binding]; other site 1286404000222 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1286404000223 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1286404000224 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1286404000225 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1286404000226 Ligand Binding Site [chemical binding]; other site 1286404000227 TilS substrate binding domain; Region: TilS; pfam09179 1286404000228 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1286404000229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404000230 active site 1286404000231 FtsH Extracellular; Region: FtsH_ext; pfam06480 1286404000232 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1286404000233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404000234 Walker A motif; other site 1286404000235 ATP binding site [chemical binding]; other site 1286404000236 Walker B motif; other site 1286404000237 arginine finger; other site 1286404000238 Peptidase family M41; Region: Peptidase_M41; pfam01434 1286404000239 pantothenate kinase; Reviewed; Region: PRK13318 1286404000240 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1286404000241 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1286404000242 dimerization interface [polypeptide binding]; other site 1286404000243 domain crossover interface; other site 1286404000244 redox-dependent activation switch; other site 1286404000245 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286404000246 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286404000247 dimer interface [polypeptide binding]; other site 1286404000248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404000249 catalytic residue [active] 1286404000250 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1286404000251 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1286404000252 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286404000253 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1286404000254 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1286404000255 glutamine binding [chemical binding]; other site 1286404000256 catalytic triad [active] 1286404000257 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286404000258 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 1286404000259 homodimer interface [polypeptide binding]; other site 1286404000260 substrate-cofactor binding pocket; other site 1286404000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404000262 catalytic residue [active] 1286404000263 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1286404000264 dihydropteroate synthase; Region: DHPS; TIGR01496 1286404000265 substrate binding pocket [chemical binding]; other site 1286404000266 dimer interface [polypeptide binding]; other site 1286404000267 inhibitor binding site; inhibition site 1286404000268 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1286404000269 homooctamer interface [polypeptide binding]; other site 1286404000270 active site 1286404000271 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1286404000272 catalytic center binding site [active] 1286404000273 ATP binding site [chemical binding]; other site 1286404000274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404000276 non-specific DNA binding site [nucleotide binding]; other site 1286404000277 salt bridge; other site 1286404000278 sequence-specific DNA binding site [nucleotide binding]; other site 1286404000279 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1286404000280 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286404000281 FMN binding site [chemical binding]; other site 1286404000282 active site 1286404000283 catalytic residues [active] 1286404000284 substrate binding site [chemical binding]; other site 1286404000285 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1286404000286 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1286404000287 dimer interface [polypeptide binding]; other site 1286404000288 putative anticodon binding site; other site 1286404000289 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1286404000290 motif 1; other site 1286404000291 active site 1286404000292 motif 2; other site 1286404000293 motif 3; other site 1286404000294 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404000295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404000296 DNA-binding site [nucleotide binding]; DNA binding site 1286404000297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404000298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404000299 homodimer interface [polypeptide binding]; other site 1286404000300 catalytic residue [active] 1286404000301 Proline dehydrogenase; Region: Pro_dh; cl03282 1286404000302 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1286404000303 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1286404000304 UvrB/uvrC motif; Region: UVR; pfam02151 1286404000305 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1286404000306 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1286404000307 ADP binding site [chemical binding]; other site 1286404000308 phosphagen binding site; other site 1286404000309 substrate specificity loop; other site 1286404000310 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1286404000311 Clp amino terminal domain; Region: Clp_N; pfam02861 1286404000312 Clp amino terminal domain; Region: Clp_N; pfam02861 1286404000313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404000314 Walker A motif; other site 1286404000315 ATP binding site [chemical binding]; other site 1286404000316 Walker B motif; other site 1286404000317 arginine finger; other site 1286404000318 UvrB/uvrC motif; Region: UVR; pfam02151 1286404000319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404000320 Walker A motif; other site 1286404000321 ATP binding site [chemical binding]; other site 1286404000322 Walker B motif; other site 1286404000323 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286404000324 DNA repair protein RadA; Provisional; Region: PRK11823 1286404000325 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1286404000326 Walker A motif/ATP binding site; other site 1286404000327 ATP binding site [chemical binding]; other site 1286404000328 Walker B motif; other site 1286404000329 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1286404000330 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1286404000331 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1286404000332 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1286404000333 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1286404000334 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1286404000335 putative active site [active] 1286404000336 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1286404000337 substrate binding site; other site 1286404000338 dimer interface; other site 1286404000339 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1286404000340 homotrimer interaction site [polypeptide binding]; other site 1286404000341 zinc binding site [ion binding]; other site 1286404000342 CDP-binding sites; other site 1286404000343 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1286404000344 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1286404000345 HIGH motif; other site 1286404000346 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1286404000347 active site 1286404000348 KMSKS motif; other site 1286404000349 serine O-acetyltransferase; Region: cysE; TIGR01172 1286404000350 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1286404000351 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1286404000352 trimer interface [polypeptide binding]; other site 1286404000353 active site 1286404000354 substrate binding site [chemical binding]; other site 1286404000355 CoA binding site [chemical binding]; other site 1286404000356 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1286404000357 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1286404000358 active site 1286404000359 HIGH motif; other site 1286404000360 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1286404000361 KMSKS motif; other site 1286404000362 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1286404000363 tRNA binding surface [nucleotide binding]; other site 1286404000364 anticodon binding site; other site 1286404000365 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1286404000366 active site 1286404000367 metal binding site [ion binding]; metal-binding site 1286404000368 dimerization interface [polypeptide binding]; other site 1286404000369 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1286404000370 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1286404000371 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286404000372 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1286404000373 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 1286404000374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404000375 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286404000376 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1286404000377 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1286404000378 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1286404000379 putative homodimer interface [polypeptide binding]; other site 1286404000380 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1286404000381 heterodimer interface [polypeptide binding]; other site 1286404000382 homodimer interface [polypeptide binding]; other site 1286404000383 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1286404000384 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1286404000385 23S rRNA interface [nucleotide binding]; other site 1286404000386 L7/L12 interface [polypeptide binding]; other site 1286404000387 putative thiostrepton binding site; other site 1286404000388 L25 interface [polypeptide binding]; other site 1286404000389 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1286404000390 mRNA/rRNA interface [nucleotide binding]; other site 1286404000391 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1286404000392 23S rRNA interface [nucleotide binding]; other site 1286404000393 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1286404000394 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1286404000395 core dimer interface [polypeptide binding]; other site 1286404000396 peripheral dimer interface [polypeptide binding]; other site 1286404000397 L10 interface [polypeptide binding]; other site 1286404000398 L11 interface [polypeptide binding]; other site 1286404000399 putative EF-Tu interaction site [polypeptide binding]; other site 1286404000400 putative EF-G interaction site [polypeptide binding]; other site 1286404000401 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1286404000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404000403 S-adenosylmethionine binding site [chemical binding]; other site 1286404000404 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 1286404000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1286404000406 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1286404000407 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1286404000408 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1286404000409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1286404000410 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1286404000411 RPB10 interaction site [polypeptide binding]; other site 1286404000412 RPB1 interaction site [polypeptide binding]; other site 1286404000413 RPB11 interaction site [polypeptide binding]; other site 1286404000414 RPB3 interaction site [polypeptide binding]; other site 1286404000415 RPB12 interaction site [polypeptide binding]; other site 1286404000416 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1286404000417 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1286404000418 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1286404000419 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1286404000420 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1286404000421 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1286404000422 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1286404000423 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1286404000424 G-loop; other site 1286404000425 DNA binding site [nucleotide binding] 1286404000426 hypothetical protein; Provisional; Region: PRK06683 1286404000427 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1286404000428 S17 interaction site [polypeptide binding]; other site 1286404000429 S8 interaction site; other site 1286404000430 16S rRNA interaction site [nucleotide binding]; other site 1286404000431 streptomycin interaction site [chemical binding]; other site 1286404000432 23S rRNA interaction site [nucleotide binding]; other site 1286404000433 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1286404000434 30S ribosomal protein S7; Validated; Region: PRK05302 1286404000435 elongation factor G; Reviewed; Region: PRK00007 1286404000436 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1286404000437 G1 box; other site 1286404000438 putative GEF interaction site [polypeptide binding]; other site 1286404000439 GTP/Mg2+ binding site [chemical binding]; other site 1286404000440 Switch I region; other site 1286404000441 G2 box; other site 1286404000442 G3 box; other site 1286404000443 Switch II region; other site 1286404000444 G4 box; other site 1286404000445 G5 box; other site 1286404000446 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1286404000447 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1286404000448 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1286404000449 elongation factor Tu; Reviewed; Region: PRK00049 1286404000450 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1286404000451 G1 box; other site 1286404000452 GEF interaction site [polypeptide binding]; other site 1286404000453 GTP/Mg2+ binding site [chemical binding]; other site 1286404000454 Switch I region; other site 1286404000455 G2 box; other site 1286404000456 G3 box; other site 1286404000457 Switch II region; other site 1286404000458 G4 box; other site 1286404000459 G5 box; other site 1286404000460 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1286404000461 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1286404000462 Antibiotic Binding Site [chemical binding]; other site 1286404000463 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1286404000464 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1286404000465 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1286404000466 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1286404000467 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1286404000468 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1286404000469 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1286404000470 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1286404000471 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1286404000472 putative translocon binding site; other site 1286404000473 protein-rRNA interface [nucleotide binding]; other site 1286404000474 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1286404000475 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1286404000476 G-X-X-G motif; other site 1286404000477 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1286404000478 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1286404000479 23S rRNA interface [nucleotide binding]; other site 1286404000480 5S rRNA interface [nucleotide binding]; other site 1286404000481 putative antibiotic binding site [chemical binding]; other site 1286404000482 L25 interface [polypeptide binding]; other site 1286404000483 L27 interface [polypeptide binding]; other site 1286404000484 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1286404000485 23S rRNA interface [nucleotide binding]; other site 1286404000486 putative translocon interaction site; other site 1286404000487 signal recognition particle (SRP54) interaction site; other site 1286404000488 L23 interface [polypeptide binding]; other site 1286404000489 trigger factor interaction site; other site 1286404000490 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1286404000491 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1286404000492 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1286404000493 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1286404000494 RNA binding site [nucleotide binding]; other site 1286404000495 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1286404000496 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1286404000497 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1286404000498 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1286404000499 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1286404000500 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1286404000501 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1286404000502 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1286404000503 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1286404000504 5S rRNA interface [nucleotide binding]; other site 1286404000505 L27 interface [polypeptide binding]; other site 1286404000506 23S rRNA interface [nucleotide binding]; other site 1286404000507 L5 interface [polypeptide binding]; other site 1286404000508 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1286404000509 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1286404000510 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1286404000511 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1286404000512 23S rRNA binding site [nucleotide binding]; other site 1286404000513 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1286404000514 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 1286404000515 SecY translocase; Region: SecY; pfam00344 1286404000516 adenylate kinase; Reviewed; Region: adk; PRK00279 1286404000517 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1286404000518 AMP-binding site [chemical binding]; other site 1286404000519 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1286404000520 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286404000521 active site 1286404000522 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1286404000523 rRNA binding site [nucleotide binding]; other site 1286404000524 predicted 30S ribosome binding site; other site 1286404000525 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1286404000526 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1286404000527 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1286404000528 30S ribosomal protein S11; Validated; Region: PRK05309 1286404000529 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1286404000530 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1286404000531 alphaNTD - beta interaction site [polypeptide binding]; other site 1286404000532 alphaNTD homodimer interface [polypeptide binding]; other site 1286404000533 alphaNTD - beta' interaction site [polypeptide binding]; other site 1286404000534 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1286404000535 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1286404000536 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1286404000537 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1286404000538 Walker A/P-loop; other site 1286404000539 ATP binding site [chemical binding]; other site 1286404000540 Q-loop/lid; other site 1286404000541 ABC transporter signature motif; other site 1286404000542 Walker B; other site 1286404000543 D-loop; other site 1286404000544 H-loop/switch region; other site 1286404000545 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1286404000546 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1286404000547 Walker A/P-loop; other site 1286404000548 ATP binding site [chemical binding]; other site 1286404000549 Q-loop/lid; other site 1286404000550 ABC transporter signature motif; other site 1286404000551 Walker B; other site 1286404000552 D-loop; other site 1286404000553 H-loop/switch region; other site 1286404000554 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1286404000555 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1286404000556 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1286404000557 dimerization interface 3.5A [polypeptide binding]; other site 1286404000558 active site 1286404000559 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1286404000560 23S rRNA interface [nucleotide binding]; other site 1286404000561 L3 interface [polypeptide binding]; other site 1286404000562 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1286404000563 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1286404000564 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286404000565 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286404000566 active site 1286404000567 metal binding site [ion binding]; metal-binding site 1286404000568 Domain of unknown function DUF59; Region: DUF59; cl00941 1286404000569 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1286404000570 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1286404000571 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1286404000572 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404000573 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1286404000574 NodB motif; other site 1286404000575 putative active site [active] 1286404000576 putative catalytic site [active] 1286404000577 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1286404000578 Arginase family; Region: Arginase; cd09989 1286404000579 agmatinase; Region: agmatinase; TIGR01230 1286404000580 active site 1286404000581 Mn binding site [ion binding]; other site 1286404000582 oligomer interface [polypeptide binding]; other site 1286404000583 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1286404000584 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1286404000585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1286404000586 YbbR-like protein; Region: YbbR; pfam07949 1286404000587 YbbR-like protein; Region: YbbR; pfam07949 1286404000588 YbbR-like protein; Region: YbbR; pfam07949 1286404000589 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1286404000590 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1286404000591 active site 1286404000592 substrate binding site [chemical binding]; other site 1286404000593 metal binding site [ion binding]; metal-binding site 1286404000594 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1286404000595 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1286404000596 glutaminase active site [active] 1286404000597 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1286404000598 dimer interface [polypeptide binding]; other site 1286404000599 active site 1286404000600 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1286404000601 dimer interface [polypeptide binding]; other site 1286404000602 active site 1286404000603 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1286404000604 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404000605 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1286404000606 Predicted membrane protein [Function unknown]; Region: COG2259 1286404000607 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 1286404000608 classical (c) SDRs; Region: SDR_c; cd05233 1286404000609 NAD(P) binding site [chemical binding]; other site 1286404000610 active site 1286404000611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404000612 ABC-ATPase subunit interface; other site 1286404000613 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1286404000614 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286404000615 Walker A/P-loop; other site 1286404000616 ATP binding site [chemical binding]; other site 1286404000617 Q-loop/lid; other site 1286404000618 ABC transporter signature motif; other site 1286404000619 Walker B; other site 1286404000620 D-loop; other site 1286404000621 H-loop/switch region; other site 1286404000622 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286404000623 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1286404000624 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286404000625 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286404000626 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404000627 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1286404000628 putative NAD(P) binding site [chemical binding]; other site 1286404000629 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286404000630 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404000631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404000632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404000633 putative substrate translocation pore; other site 1286404000634 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 1286404000635 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1286404000636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404000637 putative substrate translocation pore; other site 1286404000638 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 1286404000639 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 1286404000640 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286404000641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404000642 dimer interface [polypeptide binding]; other site 1286404000643 conserved gate region; other site 1286404000644 putative PBP binding loops; other site 1286404000645 ABC-ATPase subunit interface; other site 1286404000646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404000647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404000648 dimer interface [polypeptide binding]; other site 1286404000649 conserved gate region; other site 1286404000650 putative PBP binding loops; other site 1286404000651 ABC-ATPase subunit interface; other site 1286404000652 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286404000653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404000654 Walker A/P-loop; other site 1286404000655 ATP binding site [chemical binding]; other site 1286404000656 Q-loop/lid; other site 1286404000657 ABC transporter signature motif; other site 1286404000658 Walker B; other site 1286404000659 D-loop; other site 1286404000660 H-loop/switch region; other site 1286404000661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286404000662 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286404000663 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404000664 Walker A/P-loop; other site 1286404000665 ATP binding site [chemical binding]; other site 1286404000666 Q-loop/lid; other site 1286404000667 ABC transporter signature motif; other site 1286404000668 Walker B; other site 1286404000669 D-loop; other site 1286404000670 H-loop/switch region; other site 1286404000671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286404000672 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404000673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404000674 peptide binding site [polypeptide binding]; other site 1286404000675 YusW-like protein; Region: YusW; pfam14039 1286404000676 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404000677 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404000678 peptide binding site [polypeptide binding]; other site 1286404000679 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404000680 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404000681 peptide binding site [polypeptide binding]; other site 1286404000682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404000683 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404000684 active site 1286404000685 catalytic tetrad [active] 1286404000686 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 1286404000687 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1286404000688 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1286404000689 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1286404000690 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286404000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404000692 dimer interface [polypeptide binding]; other site 1286404000693 conserved gate region; other site 1286404000694 putative PBP binding loops; other site 1286404000695 ABC-ATPase subunit interface; other site 1286404000696 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1286404000697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286404000698 dimerization interface [polypeptide binding]; other site 1286404000699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404000700 membrane-bound complex binding site; other site 1286404000701 hinge residues; other site 1286404000702 DNA binding domain, excisionase family; Region: excise; TIGR01764 1286404000703 PBP superfamily domain; Region: PBP_like; pfam12727 1286404000704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404000705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404000706 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1286404000707 putative dimerization interface [polypeptide binding]; other site 1286404000708 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404000709 EamA-like transporter family; Region: EamA; pfam00892 1286404000710 YrzO-like protein; Region: YrzO; pfam14142 1286404000711 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286404000712 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286404000713 putative acyl-acceptor binding pocket; other site 1286404000714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404000715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404000716 DNA binding site [nucleotide binding] 1286404000717 domain linker motif; other site 1286404000718 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1286404000719 putative ligand binding site [chemical binding]; other site 1286404000720 putative dimerization interface [polypeptide binding]; other site 1286404000721 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404000722 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404000723 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404000724 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404000725 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1286404000726 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1286404000727 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1286404000728 active site 1286404000729 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1286404000730 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1286404000731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286404000732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286404000733 catalytic residue [active] 1286404000734 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1286404000735 nucleotide binding site/active site [active] 1286404000736 HIT family signature motif; other site 1286404000737 catalytic residue [active] 1286404000738 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404000739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404000740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404000741 ABC transporter; Region: ABC_tran_2; pfam12848 1286404000742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404000743 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286404000744 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286404000745 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286404000746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404000747 dimer interface [polypeptide binding]; other site 1286404000748 conserved gate region; other site 1286404000749 putative PBP binding loops; other site 1286404000750 ABC-ATPase subunit interface; other site 1286404000751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404000752 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286404000753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404000754 dimer interface [polypeptide binding]; other site 1286404000755 conserved gate region; other site 1286404000756 putative PBP binding loops; other site 1286404000757 ABC-ATPase subunit interface; other site 1286404000758 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286404000759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404000760 Walker A/P-loop; other site 1286404000761 ATP binding site [chemical binding]; other site 1286404000762 Q-loop/lid; other site 1286404000763 ABC transporter signature motif; other site 1286404000764 Walker B; other site 1286404000765 D-loop; other site 1286404000766 H-loop/switch region; other site 1286404000767 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286404000768 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286404000769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404000770 Walker A/P-loop; other site 1286404000771 ATP binding site [chemical binding]; other site 1286404000772 Q-loop/lid; other site 1286404000773 ABC transporter signature motif; other site 1286404000774 Walker B; other site 1286404000775 D-loop; other site 1286404000776 H-loop/switch region; other site 1286404000777 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286404000778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404000779 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404000780 active site 1286404000781 motif I; other site 1286404000782 motif II; other site 1286404000783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404000784 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1286404000785 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1286404000786 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1286404000787 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1286404000788 dimer interface [polypeptide binding]; other site 1286404000789 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1286404000790 active site 1286404000791 Fe binding site [ion binding]; other site 1286404000792 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286404000793 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286404000794 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1286404000795 amino acid transporter; Region: 2A0306; TIGR00909 1286404000796 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1286404000797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404000798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404000799 putative substrate translocation pore; other site 1286404000800 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1286404000801 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1286404000802 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1286404000803 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1286404000804 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286404000805 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286404000806 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286404000807 helicase 45; Provisional; Region: PTZ00424 1286404000808 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286404000809 ATP binding site [chemical binding]; other site 1286404000810 Mg++ binding site [ion binding]; other site 1286404000811 motif III; other site 1286404000812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404000813 nucleotide binding region [chemical binding]; other site 1286404000814 ATP-binding site [chemical binding]; other site 1286404000815 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1286404000816 Rhomboid family; Region: Rhomboid; pfam01694 1286404000817 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1286404000818 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1286404000819 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1286404000820 alanine racemase; Reviewed; Region: alr; PRK00053 1286404000821 active site 1286404000822 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286404000823 dimer interface [polypeptide binding]; other site 1286404000824 substrate binding site [chemical binding]; other site 1286404000825 catalytic residues [active] 1286404000826 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1286404000827 PemK-like protein; Region: PemK; pfam02452 1286404000828 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1286404000829 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1286404000830 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1286404000831 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1286404000832 RNA binding site [nucleotide binding]; other site 1286404000833 hypothetical protein; Provisional; Region: PRK04351 1286404000834 SprT homologues; Region: SprT; cl01182 1286404000835 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1286404000836 Glycoprotease family; Region: Peptidase_M22; pfam00814 1286404000837 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1286404000838 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1286404000839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404000840 Coenzyme A binding pocket [chemical binding]; other site 1286404000841 UGMP family protein; Validated; Region: PRK09604 1286404000842 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1286404000843 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1286404000844 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404000845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404000846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404000847 ABC transporter; Region: ABC_tran_2; pfam12848 1286404000848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404000849 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1286404000850 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1286404000851 CoA binding domain; Region: CoA_binding; pfam02629 1286404000852 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1286404000853 CAAX protease self-immunity; Region: Abi; pfam02517 1286404000854 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1286404000855 oligomerisation interface [polypeptide binding]; other site 1286404000856 mobile loop; other site 1286404000857 roof hairpin; other site 1286404000858 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1286404000859 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1286404000860 ring oligomerisation interface [polypeptide binding]; other site 1286404000861 ATP/Mg binding site [chemical binding]; other site 1286404000862 stacking interactions; other site 1286404000863 hinge regions; other site 1286404000864 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1286404000865 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1286404000866 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1286404000867 GMP synthase; Reviewed; Region: guaA; PRK00074 1286404000868 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1286404000869 AMP/PPi binding site [chemical binding]; other site 1286404000870 candidate oxyanion hole; other site 1286404000871 catalytic triad [active] 1286404000872 potential glutamine specificity residues [chemical binding]; other site 1286404000873 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1286404000874 ATP Binding subdomain [chemical binding]; other site 1286404000875 Ligand Binding sites [chemical binding]; other site 1286404000876 Dimerization subdomain; other site 1286404000877 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286404000878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404000879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404000880 active site 1286404000881 phosphorylation site [posttranslational modification] 1286404000882 intermolecular recognition site; other site 1286404000883 dimerization interface [polypeptide binding]; other site 1286404000884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404000885 DNA binding site [nucleotide binding] 1286404000886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404000887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404000888 dimerization interface [polypeptide binding]; other site 1286404000889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404000890 dimer interface [polypeptide binding]; other site 1286404000891 phosphorylation site [posttranslational modification] 1286404000892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404000893 ATP binding site [chemical binding]; other site 1286404000894 Mg2+ binding site [ion binding]; other site 1286404000895 G-X-G motif; other site 1286404000896 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404000897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404000898 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404000899 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1286404000900 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1286404000901 catalytic residues [active] 1286404000902 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 1286404000903 putative catalytic site [active] 1286404000904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404000905 Integrase core domain; Region: rve; pfam00665 1286404000906 transposase/IS protein; Provisional; Region: PRK09183 1286404000907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404000908 Walker A motif; other site 1286404000909 ATP binding site [chemical binding]; other site 1286404000910 Walker B motif; other site 1286404000911 arginine finger; other site 1286404000912 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 1286404000913 putative ligand binding site [chemical binding]; other site 1286404000914 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404000915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404000916 S-adenosylmethionine binding site [chemical binding]; other site 1286404000917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404000918 S-adenosylmethionine binding site [chemical binding]; other site 1286404000919 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1286404000920 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404000921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404000922 NAD(P) binding site [chemical binding]; other site 1286404000923 active site 1286404000924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404000925 S-adenosylmethionine binding site [chemical binding]; other site 1286404000926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404000927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286404000928 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404000929 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404000930 active site 1286404000931 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404000932 EamA-like transporter family; Region: EamA; pfam00892 1286404000933 EamA-like transporter family; Region: EamA; pfam00892 1286404000934 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1286404000935 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1286404000936 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1286404000937 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1286404000938 NAD binding site [chemical binding]; other site 1286404000939 ATP-grasp domain; Region: ATP-grasp; pfam02222 1286404000940 adenylosuccinate lyase; Provisional; Region: PRK07492 1286404000941 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1286404000942 tetramer interface [polypeptide binding]; other site 1286404000943 active site 1286404000944 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1286404000945 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1286404000946 ATP binding site [chemical binding]; other site 1286404000947 active site 1286404000948 substrate binding site [chemical binding]; other site 1286404000949 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1286404000950 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1286404000951 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1286404000952 putative active site [active] 1286404000953 catalytic triad [active] 1286404000954 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1286404000955 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1286404000956 dimerization interface [polypeptide binding]; other site 1286404000957 ATP binding site [chemical binding]; other site 1286404000958 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1286404000959 dimerization interface [polypeptide binding]; other site 1286404000960 ATP binding site [chemical binding]; other site 1286404000961 amidophosphoribosyltransferase; Provisional; Region: PRK06781 1286404000962 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1286404000963 active site 1286404000964 tetramer interface [polypeptide binding]; other site 1286404000965 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404000966 active site 1286404000967 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1286404000968 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1286404000969 dimerization interface [polypeptide binding]; other site 1286404000970 putative ATP binding site [chemical binding]; other site 1286404000971 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1286404000972 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1286404000973 active site 1286404000974 substrate binding site [chemical binding]; other site 1286404000975 cosubstrate binding site; other site 1286404000976 catalytic site [active] 1286404000977 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1286404000978 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1286404000979 purine monophosphate binding site [chemical binding]; other site 1286404000980 dimer interface [polypeptide binding]; other site 1286404000981 putative catalytic residues [active] 1286404000982 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1286404000983 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1286404000984 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1286404000985 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1286404000986 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1286404000987 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1286404000988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404000989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404000990 putative substrate translocation pore; other site 1286404000991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404000992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404000993 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1286404000994 putative dimerization interface [polypeptide binding]; other site 1286404000995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1286404000996 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1286404000997 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1286404000998 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1286404000999 PcrB family; Region: PcrB; pfam01884 1286404001000 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1286404001001 substrate binding site [chemical binding]; other site 1286404001002 putative active site [active] 1286404001003 dimer interface [polypeptide binding]; other site 1286404001004 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1286404001005 Part of AAA domain; Region: AAA_19; pfam13245 1286404001006 Family description; Region: UvrD_C_2; pfam13538 1286404001007 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1286404001008 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1286404001009 nucleotide binding pocket [chemical binding]; other site 1286404001010 K-X-D-G motif; other site 1286404001011 catalytic site [active] 1286404001012 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1286404001013 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1286404001014 Dimer interface [polypeptide binding]; other site 1286404001015 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1286404001016 putative dimer interface [polypeptide binding]; other site 1286404001017 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1286404001018 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1286404001019 putative dimer interface [polypeptide binding]; other site 1286404001020 hypothetical protein; Provisional; Region: PRK10621 1286404001021 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404001022 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1286404001023 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1286404001024 Glutamate binding site [chemical binding]; other site 1286404001025 homodimer interface [polypeptide binding]; other site 1286404001026 NAD binding site [chemical binding]; other site 1286404001027 catalytic residues [active] 1286404001028 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404001029 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286404001030 catalytic triad [active] 1286404001031 conserved cis-peptide bond; other site 1286404001032 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1286404001033 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286404001034 Walker A/P-loop; other site 1286404001035 ATP binding site [chemical binding]; other site 1286404001036 Q-loop/lid; other site 1286404001037 ABC transporter signature motif; other site 1286404001038 Walker B; other site 1286404001039 D-loop; other site 1286404001040 H-loop/switch region; other site 1286404001041 NIL domain; Region: NIL; pfam09383 1286404001042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001043 dimer interface [polypeptide binding]; other site 1286404001044 conserved gate region; other site 1286404001045 ABC-ATPase subunit interface; other site 1286404001046 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286404001047 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286404001048 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 1286404001049 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1286404001050 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1286404001051 P loop; other site 1286404001052 Nucleotide binding site [chemical binding]; other site 1286404001053 DTAP/Switch II; other site 1286404001054 Switch I; other site 1286404001055 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1286404001056 putative dimer interface [polypeptide binding]; other site 1286404001057 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404001058 MarR family; Region: MarR; pfam01047 1286404001059 MarR family; Region: MarR_2; cl17246 1286404001060 yiaA/B two helix domain; Region: YiaAB; pfam05360 1286404001061 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1286404001062 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1286404001063 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1286404001064 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1286404001065 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1286404001066 GatB domain; Region: GatB_Yqey; pfam02637 1286404001067 putative lipid kinase; Reviewed; Region: PRK13337 1286404001068 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1286404001069 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286404001070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404001071 motif II; other site 1286404001072 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1286404001073 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404001074 inhibitor-cofactor binding pocket; inhibition site 1286404001075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404001076 catalytic residue [active] 1286404001077 PAS domain; Region: PAS_9; pfam13426 1286404001078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404001079 putative active site [active] 1286404001080 heme pocket [chemical binding]; other site 1286404001081 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1286404001082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404001083 Walker A motif; other site 1286404001084 ATP binding site [chemical binding]; other site 1286404001085 Walker B motif; other site 1286404001086 arginine finger; other site 1286404001087 succinic semialdehyde dehydrogenase; Region: PLN02278 1286404001088 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1286404001089 tetramerization interface [polypeptide binding]; other site 1286404001090 NAD(P) binding site [chemical binding]; other site 1286404001091 catalytic residues [active] 1286404001092 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404001093 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1286404001094 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1286404001095 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1286404001096 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404001097 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1286404001098 putative active site [active] 1286404001099 putative metal binding site [ion binding]; other site 1286404001100 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404001101 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404001102 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404001103 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1286404001104 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1286404001105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404001106 S-adenosylmethionine binding site [chemical binding]; other site 1286404001107 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1286404001108 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1286404001109 FMN binding site [chemical binding]; other site 1286404001110 active site 1286404001111 catalytic residues [active] 1286404001112 substrate binding site [chemical binding]; other site 1286404001113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1286404001114 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1286404001115 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1286404001116 Protein of unknown function DUF45; Region: DUF45; pfam01863 1286404001117 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1286404001118 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1286404001119 active site 1286404001120 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1286404001121 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1286404001122 amidohydrolase; Region: amidohydrolases; TIGR01891 1286404001123 metal binding site [ion binding]; metal-binding site 1286404001124 putative dimer interface [polypeptide binding]; other site 1286404001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404001126 S-adenosylmethionine binding site [chemical binding]; other site 1286404001127 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1286404001128 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1286404001129 catalytic residue [active] 1286404001130 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1286404001131 catalytic residues [active] 1286404001132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404001133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404001134 peroxiredoxin; Region: AhpC; TIGR03137 1286404001135 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1286404001136 dimer interface [polypeptide binding]; other site 1286404001137 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1286404001138 catalytic triad [active] 1286404001139 peroxidatic and resolving cysteines [active] 1286404001140 5-methylribose kinase; Reviewed; Region: PRK12396 1286404001141 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404001142 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1286404001143 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1286404001144 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 1286404001145 intersubunit interface [polypeptide binding]; other site 1286404001146 active site 1286404001147 Zn2+ binding site [ion binding]; other site 1286404001148 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404001149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404001150 ABC-ATPase subunit interface; other site 1286404001151 dimer interface [polypeptide binding]; other site 1286404001152 putative PBP binding regions; other site 1286404001153 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404001154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404001155 ABC-ATPase subunit interface; other site 1286404001156 dimer interface [polypeptide binding]; other site 1286404001157 putative PBP binding regions; other site 1286404001158 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286404001159 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1286404001160 putative ligand binding residues [chemical binding]; other site 1286404001161 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1286404001162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404001163 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1286404001164 DNA binding domain, excisionase family; Region: excise; TIGR01764 1286404001165 Sm and related proteins; Region: Sm_like; cl00259 1286404001166 Sm1 motif; other site 1286404001167 RNA binding site [nucleotide binding]; other site 1286404001168 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1286404001169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404001170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404001171 dimer interface [polypeptide binding]; other site 1286404001172 phosphorylation site [posttranslational modification] 1286404001173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404001174 ATP binding site [chemical binding]; other site 1286404001175 Mg2+ binding site [ion binding]; other site 1286404001176 G-X-G motif; other site 1286404001177 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1286404001178 hypothetical protein; Provisional; Region: PRK06851 1286404001179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404001180 Walker A motif; other site 1286404001181 ATP binding site [chemical binding]; other site 1286404001182 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1286404001183 benzoate transport; Region: 2A0115; TIGR00895 1286404001184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404001185 putative substrate translocation pore; other site 1286404001186 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286404001187 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1286404001188 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1286404001189 [2Fe-2S] cluster binding site [ion binding]; other site 1286404001190 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1286404001191 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1286404001192 putative di-iron ligands [ion binding]; other site 1286404001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001194 dimer interface [polypeptide binding]; other site 1286404001195 conserved gate region; other site 1286404001196 putative PBP binding loops; other site 1286404001197 ABC-ATPase subunit interface; other site 1286404001198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286404001199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404001200 substrate binding pocket [chemical binding]; other site 1286404001201 membrane-bound complex binding site; other site 1286404001202 hinge residues; other site 1286404001203 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286404001204 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286404001205 Walker A/P-loop; other site 1286404001206 ATP binding site [chemical binding]; other site 1286404001207 Q-loop/lid; other site 1286404001208 ABC transporter signature motif; other site 1286404001209 Walker B; other site 1286404001210 D-loop; other site 1286404001211 H-loop/switch region; other site 1286404001212 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1286404001213 HAMP domain; Region: HAMP; pfam00672 1286404001214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404001215 dimer interface [polypeptide binding]; other site 1286404001216 putative CheW interface [polypeptide binding]; other site 1286404001217 Arginine repressor [Transcription]; Region: ArgR; COG1438 1286404001218 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1286404001219 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1286404001220 arginine deiminase; Provisional; Region: PRK01388 1286404001221 ornithine carbamoyltransferase; Validated; Region: PRK02102 1286404001222 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286404001223 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286404001224 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1286404001225 carbamate kinase; Reviewed; Region: PRK12686 1286404001226 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1286404001227 putative substrate binding site [chemical binding]; other site 1286404001228 nucleotide binding site [chemical binding]; other site 1286404001229 nucleotide binding site [chemical binding]; other site 1286404001230 homodimer interface [polypeptide binding]; other site 1286404001231 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286404001232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286404001233 ligand binding site [chemical binding]; other site 1286404001234 flexible hinge region; other site 1286404001235 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286404001236 putative switch regulator; other site 1286404001237 non-specific DNA interactions [nucleotide binding]; other site 1286404001238 DNA binding site [nucleotide binding] 1286404001239 sequence specific DNA binding site [nucleotide binding]; other site 1286404001240 putative cAMP binding site [chemical binding]; other site 1286404001241 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1286404001242 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286404001243 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404001244 Berberine and berberine like; Region: BBE; pfam08031 1286404001245 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1286404001246 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1286404001247 Ca binding site [ion binding]; other site 1286404001248 active site 1286404001249 catalytic site [active] 1286404001250 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404001251 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1286404001252 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286404001253 active site turn [active] 1286404001254 phosphorylation site [posttranslational modification] 1286404001255 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1286404001256 putative catalytic site [active] 1286404001257 putative metal binding site [ion binding]; other site 1286404001258 putative phosphate binding site [ion binding]; other site 1286404001259 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1286404001260 Predicted membrane protein [Function unknown]; Region: COG1511 1286404001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404001262 DNA topoisomerase III; Provisional; Region: PRK07726 1286404001263 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1286404001264 active site 1286404001265 putative interdomain interaction site [polypeptide binding]; other site 1286404001266 putative metal-binding site [ion binding]; other site 1286404001267 putative nucleotide binding site [chemical binding]; other site 1286404001268 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286404001269 domain I; other site 1286404001270 DNA binding groove [nucleotide binding] 1286404001271 phosphate binding site [ion binding]; other site 1286404001272 domain II; other site 1286404001273 domain III; other site 1286404001274 nucleotide binding site [chemical binding]; other site 1286404001275 catalytic site [active] 1286404001276 domain IV; other site 1286404001277 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1286404001278 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1286404001279 substrate binding site [chemical binding]; other site 1286404001280 multimerization interface [polypeptide binding]; other site 1286404001281 ATP binding site [chemical binding]; other site 1286404001282 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1286404001283 thiamine phosphate binding site [chemical binding]; other site 1286404001284 active site 1286404001285 pyrophosphate binding site [ion binding]; other site 1286404001286 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1286404001287 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1286404001288 HAMP domain; Region: HAMP; pfam00672 1286404001289 dimerization interface [polypeptide binding]; other site 1286404001290 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404001291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404001292 dimer interface [polypeptide binding]; other site 1286404001293 putative CheW interface [polypeptide binding]; other site 1286404001294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404001295 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404001296 acyl-activating enzyme (AAE) consensus motif; other site 1286404001297 AMP binding site [chemical binding]; other site 1286404001298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404001299 thioester reductase domain; Region: Thioester-redct; TIGR01746 1286404001300 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1286404001301 putative NAD(P) binding site [chemical binding]; other site 1286404001302 active site 1286404001303 putative substrate binding site [chemical binding]; other site 1286404001304 Domain of unknown function DUF77; Region: DUF77; pfam01910 1286404001305 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286404001306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001307 dimer interface [polypeptide binding]; other site 1286404001308 conserved gate region; other site 1286404001309 putative PBP binding loops; other site 1286404001310 ABC-ATPase subunit interface; other site 1286404001311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1286404001312 NMT1/THI5 like; Region: NMT1; pfam09084 1286404001313 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1286404001314 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286404001315 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286404001316 Walker A/P-loop; other site 1286404001317 ATP binding site [chemical binding]; other site 1286404001318 Q-loop/lid; other site 1286404001319 ABC transporter signature motif; other site 1286404001320 Walker B; other site 1286404001321 D-loop; other site 1286404001322 H-loop/switch region; other site 1286404001323 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404001324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404001325 Walker A/P-loop; other site 1286404001326 ATP binding site [chemical binding]; other site 1286404001327 Q-loop/lid; other site 1286404001328 ABC transporter signature motif; other site 1286404001329 Walker B; other site 1286404001330 D-loop; other site 1286404001331 H-loop/switch region; other site 1286404001332 ABC transporter; Region: ABC_tran_2; pfam12848 1286404001333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404001334 Glyco_18 domain; Region: Glyco_18; smart00636 1286404001335 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1286404001336 active site 1286404001337 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404001338 Interdomain contacts; other site 1286404001339 Cytokine receptor motif; other site 1286404001340 Cellulose binding domain; Region: CBM_2; pfam00553 1286404001341 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1286404001342 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404001343 catalytic residues [active] 1286404001344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404001345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404001346 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1286404001347 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404001348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404001349 putative substrate translocation pore; other site 1286404001350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404001351 non-specific DNA binding site [nucleotide binding]; other site 1286404001352 salt bridge; other site 1286404001353 sequence-specific DNA binding site [nucleotide binding]; other site 1286404001354 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1286404001355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404001356 putative substrate translocation pore; other site 1286404001357 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1286404001358 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1286404001359 YesK-like protein; Region: YesK; pfam14150 1286404001360 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1286404001361 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1286404001362 dimer interface [polypeptide binding]; other site 1286404001363 motif 1; other site 1286404001364 active site 1286404001365 motif 2; other site 1286404001366 motif 3; other site 1286404001367 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1286404001368 anticodon binding site; other site 1286404001369 zinc-binding site [ion binding]; other site 1286404001370 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286404001371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286404001372 nucleotide binding site [chemical binding]; other site 1286404001373 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1286404001374 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1286404001375 putative metal binding site [ion binding]; other site 1286404001376 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1286404001377 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1286404001378 putative metal binding site [ion binding]; other site 1286404001379 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1286404001380 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1286404001381 putative metal binding site [ion binding]; other site 1286404001382 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1286404001383 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1286404001384 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1286404001385 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1286404001386 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1286404001387 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404001388 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286404001389 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286404001390 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286404001391 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1286404001392 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1286404001393 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1286404001394 active site 1286404001395 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 1286404001396 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1286404001397 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1286404001398 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404001399 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286404001400 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404001401 EamA-like transporter family; Region: EamA; pfam00892 1286404001402 EamA-like transporter family; Region: EamA; pfam00892 1286404001403 YhhN-like protein; Region: YhhN; pfam07947 1286404001404 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286404001405 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404001406 Catalytic site [active] 1286404001407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404001408 binding surface 1286404001409 TPR motif; other site 1286404001410 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404001411 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404001412 Predicted membrane protein [Function unknown]; Region: COG2510 1286404001413 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1286404001414 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1286404001415 calcium/proton exchanger (cax); Region: cax; TIGR00378 1286404001416 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1286404001417 YfkD-like protein; Region: YfkD; pfam14167 1286404001418 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1286404001419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404001420 FeS/SAM binding site; other site 1286404001421 YfkB-like domain; Region: YfkB; pfam08756 1286404001422 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1286404001423 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1286404001424 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1286404001425 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1286404001426 NodB motif; other site 1286404001427 active site 1286404001428 catalytic site [active] 1286404001429 Cd binding site [ion binding]; other site 1286404001430 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286404001431 endonuclease III; Region: ENDO3c; smart00478 1286404001432 minor groove reading motif; other site 1286404001433 helix-hairpin-helix signature motif; other site 1286404001434 substrate binding pocket [chemical binding]; other site 1286404001435 active site 1286404001436 TRAM domain; Region: TRAM; pfam01938 1286404001437 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1286404001438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404001439 S-adenosylmethionine binding site [chemical binding]; other site 1286404001440 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 1286404001441 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1286404001442 dimerization interface 3.5A [polypeptide binding]; other site 1286404001443 active site 1286404001444 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1286404001445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404001446 Walker A motif; other site 1286404001447 ATP binding site [chemical binding]; other site 1286404001448 Walker B motif; other site 1286404001449 arginine finger; other site 1286404001450 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286404001451 hypothetical protein; Validated; Region: PRK06748 1286404001452 S-methylmethionine transporter; Provisional; Region: PRK11387 1286404001453 acetylornithine deacetylase; Validated; Region: PRK08596 1286404001454 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1286404001455 metal binding site [ion binding]; metal-binding site 1286404001456 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404001457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404001458 non-specific DNA binding site [nucleotide binding]; other site 1286404001459 salt bridge; other site 1286404001460 sequence-specific DNA binding site [nucleotide binding]; other site 1286404001461 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1286404001462 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1286404001463 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1286404001464 glutaminase A; Region: Gln_ase; TIGR03814 1286404001465 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1286404001466 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1286404001467 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404001468 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404001469 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286404001470 active site turn [active] 1286404001471 phosphorylation site [posttranslational modification] 1286404001472 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404001473 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404001474 Sm and related proteins; Region: Sm_like; cl00259 1286404001475 heptamer interface [polypeptide binding]; other site 1286404001476 Sm1 motif; other site 1286404001477 hexamer interface [polypeptide binding]; other site 1286404001478 RNA binding site [nucleotide binding]; other site 1286404001479 Sm2 motif; other site 1286404001480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286404001481 active site 1286404001482 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404001483 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1286404001484 active site 1286404001485 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1286404001486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404001487 NAD(P) binding site [chemical binding]; other site 1286404001488 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286404001489 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1286404001490 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404001491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404001492 NAD(P) binding site [chemical binding]; other site 1286404001493 active site 1286404001494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404001495 active site 1286404001496 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404001497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404001498 active site 1286404001499 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1286404001500 Pyruvate formate lyase 1; Region: PFL1; cd01678 1286404001501 coenzyme A binding site [chemical binding]; other site 1286404001502 active site 1286404001503 catalytic residues [active] 1286404001504 glycine loop; other site 1286404001505 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1286404001506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404001507 FeS/SAM binding site; other site 1286404001508 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1286404001509 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1286404001510 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286404001511 YfhE-like protein; Region: YfhE; pfam14152 1286404001512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404001513 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1286404001514 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1286404001515 active site 1286404001516 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1286404001517 TIGR01777 family protein; Region: yfcH 1286404001518 putative NAD(P) binding site [chemical binding]; other site 1286404001519 putative active site [active] 1286404001520 recombination regulator RecX; Provisional; Region: recX; PRK14135 1286404001521 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1286404001522 YpzG-like protein; Region: YpzG; pfam14139 1286404001523 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1286404001524 WVELL protein; Region: WVELL; pfam14043 1286404001525 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1286404001526 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1286404001527 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286404001528 minor groove reading motif; other site 1286404001529 helix-hairpin-helix signature motif; other site 1286404001530 substrate binding pocket [chemical binding]; other site 1286404001531 active site 1286404001532 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1286404001533 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1286404001534 DNA binding and oxoG recognition site [nucleotide binding] 1286404001535 YgaB-like protein; Region: YgaB; pfam14182 1286404001536 hypothetical protein; Provisional; Region: PRK13662 1286404001537 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404001538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404001539 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1286404001540 Walker A/P-loop; other site 1286404001541 ATP binding site [chemical binding]; other site 1286404001542 Q-loop/lid; other site 1286404001543 ABC transporter signature motif; other site 1286404001544 Walker B; other site 1286404001545 D-loop; other site 1286404001546 H-loop/switch region; other site 1286404001547 Predicted membrane protein [Function unknown]; Region: COG4129 1286404001548 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1286404001549 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1286404001550 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1286404001551 active site 1286404001552 dimer interface [polypeptide binding]; other site 1286404001553 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1286404001554 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1286404001555 active site 1286404001556 FMN binding site [chemical binding]; other site 1286404001557 substrate binding site [chemical binding]; other site 1286404001558 3Fe-4S cluster binding site [ion binding]; other site 1286404001559 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1286404001560 domain_subunit interface; other site 1286404001561 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1286404001562 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404001563 inhibitor-cofactor binding pocket; inhibition site 1286404001564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404001565 catalytic residue [active] 1286404001566 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1286404001567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404001568 Walker A/P-loop; other site 1286404001569 ATP binding site [chemical binding]; other site 1286404001570 Q-loop/lid; other site 1286404001571 ABC transporter signature motif; other site 1286404001572 Walker B; other site 1286404001573 D-loop; other site 1286404001574 H-loop/switch region; other site 1286404001575 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1286404001576 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1286404001577 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1286404001578 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1286404001579 Ion channel; Region: Ion_trans_2; pfam07885 1286404001580 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1286404001581 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1286404001582 catalytic triad [active] 1286404001583 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286404001584 metal binding site 2 [ion binding]; metal-binding site 1286404001585 putative DNA binding helix; other site 1286404001586 metal binding site 1 [ion binding]; metal-binding site 1286404001587 dimer interface [polypeptide binding]; other site 1286404001588 structural Zn2+ binding site [ion binding]; other site 1286404001589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404001590 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404001591 Coenzyme A binding pocket [chemical binding]; other site 1286404001592 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1286404001593 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1286404001594 hypothetical protein; Provisional; Region: PRK12378 1286404001595 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286404001596 nudix motif; other site 1286404001597 Transglycosylase; Region: Transgly; pfam00912 1286404001598 Thioredoxin; Region: Thioredoxin_4; pfam13462 1286404001599 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1286404001600 epoxyqueuosine reductase; Region: TIGR00276 1286404001601 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1286404001602 4Fe-4S binding domain; Region: Fer4; cl02805 1286404001603 Putative amidase domain; Region: Amidase_6; pfam12671 1286404001604 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1286404001605 PAS fold; Region: PAS_4; pfam08448 1286404001606 PAS domain; Region: PAS_9; pfam13426 1286404001607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404001608 putative active site [active] 1286404001609 heme pocket [chemical binding]; other site 1286404001610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404001611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404001612 metal binding site [ion binding]; metal-binding site 1286404001613 active site 1286404001614 I-site; other site 1286404001615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404001616 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1286404001617 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1286404001618 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1286404001619 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404001620 heme-binding site [chemical binding]; other site 1286404001621 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001622 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1286404001623 Leucine-rich repeats; other site 1286404001624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001625 Substrate binding site [chemical binding]; other site 1286404001626 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001628 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001629 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001630 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001631 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404001632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404001633 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404001634 Coenzyme A binding pocket [chemical binding]; other site 1286404001635 BCCT family transporter; Region: BCCT; pfam02028 1286404001636 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1286404001637 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1286404001638 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1286404001639 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286404001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1286404001641 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1286404001642 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1286404001643 Cache domain; Region: Cache_1; pfam02743 1286404001644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404001645 dimerization interface [polypeptide binding]; other site 1286404001646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404001647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404001648 dimer interface [polypeptide binding]; other site 1286404001649 putative CheW interface [polypeptide binding]; other site 1286404001650 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1286404001651 PAS domain; Region: PAS; smart00091 1286404001652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404001653 ATP binding site [chemical binding]; other site 1286404001654 Mg2+ binding site [ion binding]; other site 1286404001655 G-X-G motif; other site 1286404001656 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1286404001657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404001658 active site 1286404001659 phosphorylation site [posttranslational modification] 1286404001660 intermolecular recognition site; other site 1286404001661 dimerization interface [polypeptide binding]; other site 1286404001662 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1286404001663 Citrate transporter; Region: CitMHS; pfam03600 1286404001664 hypothetical protein; Provisional; Region: PRK12784 1286404001665 NosL; Region: NosL; cl01769 1286404001666 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286404001667 Ankyrin repeat; Region: Ank; pfam00023 1286404001668 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1286404001669 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286404001670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404001671 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1286404001672 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286404001673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404001674 Walker A/P-loop; other site 1286404001675 ATP binding site [chemical binding]; other site 1286404001676 Q-loop/lid; other site 1286404001677 ABC transporter signature motif; other site 1286404001678 Walker B; other site 1286404001679 D-loop; other site 1286404001680 H-loop/switch region; other site 1286404001681 TOBE domain; Region: TOBE_2; pfam08402 1286404001682 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1286404001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001684 dimer interface [polypeptide binding]; other site 1286404001685 conserved gate region; other site 1286404001686 putative PBP binding loops; other site 1286404001687 ABC-ATPase subunit interface; other site 1286404001688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286404001689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286404001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001691 dimer interface [polypeptide binding]; other site 1286404001692 conserved gate region; other site 1286404001693 putative PBP binding loops; other site 1286404001694 ABC-ATPase subunit interface; other site 1286404001695 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1286404001696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286404001697 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404001698 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1286404001699 active site 1286404001700 metal binding site [ion binding]; metal-binding site 1286404001701 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404001702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404001703 active site 1286404001704 phosphorylation site [posttranslational modification] 1286404001705 intermolecular recognition site; other site 1286404001706 dimerization interface [polypeptide binding]; other site 1286404001707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404001708 DNA binding site [nucleotide binding] 1286404001709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404001710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404001711 dimer interface [polypeptide binding]; other site 1286404001712 phosphorylation site [posttranslational modification] 1286404001713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404001714 ATP binding site [chemical binding]; other site 1286404001715 Mg2+ binding site [ion binding]; other site 1286404001716 G-X-G motif; other site 1286404001717 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1286404001718 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1286404001719 putative active site [active] 1286404001720 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1286404001721 Cache domain; Region: Cache_1; pfam02743 1286404001722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404001723 dimerization interface [polypeptide binding]; other site 1286404001724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404001725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404001726 dimer interface [polypeptide binding]; other site 1286404001727 putative CheW interface [polypeptide binding]; other site 1286404001728 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1286404001729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404001730 ATP binding site [chemical binding]; other site 1286404001731 Mg2+ binding site [ion binding]; other site 1286404001732 G-X-G motif; other site 1286404001733 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1286404001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404001735 active site 1286404001736 phosphorylation site [posttranslational modification] 1286404001737 intermolecular recognition site; other site 1286404001738 dimerization interface [polypeptide binding]; other site 1286404001739 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1286404001740 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1286404001741 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286404001742 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1286404001743 putative NAD(P) binding site [chemical binding]; other site 1286404001744 EamA-like transporter family; Region: EamA; pfam00892 1286404001745 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404001746 EamA-like transporter family; Region: EamA; pfam00892 1286404001747 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404001748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404001749 DNA-binding site [nucleotide binding]; DNA binding site 1286404001750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404001751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404001752 homodimer interface [polypeptide binding]; other site 1286404001753 catalytic residue [active] 1286404001754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1286404001755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404001756 Coenzyme A binding pocket [chemical binding]; other site 1286404001757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404001758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404001759 dimerization interface [polypeptide binding]; other site 1286404001760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404001761 dimer interface [polypeptide binding]; other site 1286404001762 phosphorylation site [posttranslational modification] 1286404001763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404001764 ATP binding site [chemical binding]; other site 1286404001765 Mg2+ binding site [ion binding]; other site 1286404001766 G-X-G motif; other site 1286404001767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404001768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404001769 active site 1286404001770 phosphorylation site [posttranslational modification] 1286404001771 intermolecular recognition site; other site 1286404001772 dimerization interface [polypeptide binding]; other site 1286404001773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404001774 DNA binding site [nucleotide binding] 1286404001775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1286404001776 Arrestin_N terminal like; Region: LDB19; pfam13002 1286404001777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404001778 Coenzyme A binding pocket [chemical binding]; other site 1286404001779 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1286404001780 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1286404001781 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286404001782 catalytic loop [active] 1286404001783 iron binding site [ion binding]; other site 1286404001784 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1286404001785 4Fe-4S binding domain; Region: Fer4; pfam00037 1286404001786 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1286404001787 [4Fe-4S] binding site [ion binding]; other site 1286404001788 molybdopterin cofactor binding site; other site 1286404001789 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1286404001790 molybdopterin cofactor binding site; other site 1286404001791 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1286404001792 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1286404001793 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286404001794 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1286404001795 putative active site [active] 1286404001796 catalytic site [active] 1286404001797 putative metal binding site [ion binding]; other site 1286404001798 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1286404001799 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1286404001800 hexamer interface [polypeptide binding]; other site 1286404001801 ligand binding site [chemical binding]; other site 1286404001802 putative active site [active] 1286404001803 NAD(P) binding site [chemical binding]; other site 1286404001804 amino acid transporter; Region: 2A0306; TIGR00909 1286404001805 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1286404001806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404001807 dimerization interface [polypeptide binding]; other site 1286404001808 putative DNA binding site [nucleotide binding]; other site 1286404001809 putative Zn2+ binding site [ion binding]; other site 1286404001810 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286404001811 metal-binding site [ion binding] 1286404001812 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286404001813 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286404001814 metal-binding site [ion binding] 1286404001815 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404001816 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286404001817 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1286404001818 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1286404001819 active site 1286404001820 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404001821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404001822 non-specific DNA binding site [nucleotide binding]; other site 1286404001823 salt bridge; other site 1286404001824 sequence-specific DNA binding site [nucleotide binding]; other site 1286404001825 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404001826 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404001827 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404001828 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1286404001829 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404001830 active site 1286404001831 Zn binding site [ion binding]; other site 1286404001832 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1286404001833 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404001834 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1286404001835 VanW like protein; Region: VanW; pfam04294 1286404001836 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1286404001837 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404001838 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404001839 Nucleoside recognition; Region: Gate; pfam07670 1286404001840 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404001841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404001842 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1286404001843 putative metal binding site [ion binding]; other site 1286404001844 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286404001845 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286404001846 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286404001847 Transporter associated domain; Region: CorC_HlyC; smart01091 1286404001848 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1286404001849 Aspartase; Region: Aspartase; cd01357 1286404001850 active sites [active] 1286404001851 tetramer interface [polypeptide binding]; other site 1286404001852 L-lactate permease; Region: Lactate_perm; cl00701 1286404001853 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1286404001854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404001855 dimerization interface [polypeptide binding]; other site 1286404001856 putative Zn2+ binding site [ion binding]; other site 1286404001857 putative DNA binding site [nucleotide binding]; other site 1286404001858 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 1286404001859 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1286404001860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404001861 putative substrate translocation pore; other site 1286404001862 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286404001863 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1286404001864 siderophore binding site; other site 1286404001865 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404001866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404001867 ABC-ATPase subunit interface; other site 1286404001868 dimer interface [polypeptide binding]; other site 1286404001869 putative PBP binding regions; other site 1286404001870 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286404001871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404001872 ABC-ATPase subunit interface; other site 1286404001873 dimer interface [polypeptide binding]; other site 1286404001874 putative PBP binding regions; other site 1286404001875 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286404001876 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286404001877 Walker A/P-loop; other site 1286404001878 ATP binding site [chemical binding]; other site 1286404001879 Q-loop/lid; other site 1286404001880 ABC transporter signature motif; other site 1286404001881 Walker B; other site 1286404001882 D-loop; other site 1286404001883 H-loop/switch region; other site 1286404001884 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404001885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404001886 S-adenosylmethionine binding site [chemical binding]; other site 1286404001887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286404001888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404001889 catalytic residue [active] 1286404001890 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404001891 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404001892 putative active site [active] 1286404001893 putative NTP binding site [chemical binding]; other site 1286404001894 putative nucleic acid binding site [nucleotide binding]; other site 1286404001895 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404001896 active site 1286404001897 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286404001898 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404001899 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 1286404001900 NAD binding site [chemical binding]; other site 1286404001901 homodimer interface [polypeptide binding]; other site 1286404001902 active site 1286404001903 putative substrate binding site [chemical binding]; other site 1286404001904 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286404001905 nudix motif; other site 1286404001906 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1286404001907 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1286404001908 metal ion-dependent adhesion site (MIDAS); other site 1286404001909 MoxR-like ATPases [General function prediction only]; Region: COG0714 1286404001910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404001911 Walker A motif; other site 1286404001912 ATP binding site [chemical binding]; other site 1286404001913 Walker B motif; other site 1286404001914 arginine finger; other site 1286404001915 cardiolipin synthetase; Reviewed; Region: PRK12452 1286404001916 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1286404001917 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1286404001918 putative active site [active] 1286404001919 catalytic site [active] 1286404001920 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1286404001921 putative active site [active] 1286404001922 catalytic site [active] 1286404001923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404001924 PAS domain; Region: PAS_9; pfam13426 1286404001925 putative active site [active] 1286404001926 heme pocket [chemical binding]; other site 1286404001927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404001928 metal binding site [ion binding]; metal-binding site 1286404001929 active site 1286404001930 I-site; other site 1286404001931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404001932 Amino acid permease; Region: AA_permease_2; pfam13520 1286404001933 Spore germination protein; Region: Spore_permease; cl17796 1286404001934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404001935 DNA-binding site [nucleotide binding]; DNA binding site 1286404001936 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1286404001937 UTRA domain; Region: UTRA; pfam07702 1286404001938 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1286404001939 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286404001940 active site turn [active] 1286404001941 phosphorylation site [posttranslational modification] 1286404001942 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404001943 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1286404001944 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1286404001945 Ca binding site [ion binding]; other site 1286404001946 active site 1286404001947 catalytic site [active] 1286404001948 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404001949 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404001950 Spore germination protein; Region: Spore_permease; cl17796 1286404001951 Spore germination protein; Region: Spore_permease; cl17796 1286404001952 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404001953 CAAX protease self-immunity; Region: Abi; pfam02517 1286404001954 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404001955 active site 1286404001956 ATP binding site [chemical binding]; other site 1286404001957 substrate binding site [chemical binding]; other site 1286404001958 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404001959 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1286404001960 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286404001961 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286404001962 Walker A/P-loop; other site 1286404001963 ATP binding site [chemical binding]; other site 1286404001964 Q-loop/lid; other site 1286404001965 ABC transporter signature motif; other site 1286404001966 Walker B; other site 1286404001967 D-loop; other site 1286404001968 H-loop/switch region; other site 1286404001969 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286404001970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404001971 substrate binding pocket [chemical binding]; other site 1286404001972 membrane-bound complex binding site; other site 1286404001973 hinge residues; other site 1286404001974 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286404001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001976 dimer interface [polypeptide binding]; other site 1286404001977 conserved gate region; other site 1286404001978 putative PBP binding loops; other site 1286404001979 ABC-ATPase subunit interface; other site 1286404001980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404001981 dimer interface [polypeptide binding]; other site 1286404001982 conserved gate region; other site 1286404001983 putative PBP binding loops; other site 1286404001984 ABC-ATPase subunit interface; other site 1286404001985 S-methylmethionine transporter; Provisional; Region: PRK11387 1286404001986 OsmC-like protein; Region: OsmC; pfam02566 1286404001987 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1286404001988 nucleotide binding site/active site [active] 1286404001989 HIT family signature motif; other site 1286404001990 catalytic residue [active] 1286404001991 RNA polymerase sigma factor; Provisional; Region: PRK12542 1286404001992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404001993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404001994 DNA binding residues [nucleotide binding] 1286404001995 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1286404001996 Predicted transcriptional regulator [Transcription]; Region: COG2378 1286404001997 HTH domain; Region: HTH_11; pfam08279 1286404001998 WYL domain; Region: WYL; pfam13280 1286404001999 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286404002000 RibD C-terminal domain; Region: RibD_C; cl17279 1286404002001 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1286404002002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404002003 dimerization interface [polypeptide binding]; other site 1286404002004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404002005 dimer interface [polypeptide binding]; other site 1286404002006 phosphorylation site [posttranslational modification] 1286404002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404002008 ATP binding site [chemical binding]; other site 1286404002009 Mg2+ binding site [ion binding]; other site 1286404002010 G-X-G motif; other site 1286404002011 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404002012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404002013 active site 1286404002014 phosphorylation site [posttranslational modification] 1286404002015 intermolecular recognition site; other site 1286404002016 dimerization interface [polypeptide binding]; other site 1286404002017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404002018 DNA binding site [nucleotide binding] 1286404002019 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1286404002020 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1286404002021 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1286404002022 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1286404002023 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1286404002024 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286404002025 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1286404002026 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286404002027 Ligand Binding Site [chemical binding]; other site 1286404002028 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 1286404002029 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1286404002030 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1286404002031 peptide binding site [polypeptide binding]; other site 1286404002032 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1286404002033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002034 dimer interface [polypeptide binding]; other site 1286404002035 conserved gate region; other site 1286404002036 putative PBP binding loops; other site 1286404002037 ABC-ATPase subunit interface; other site 1286404002038 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286404002039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002040 putative PBP binding loops; other site 1286404002041 ABC-ATPase subunit interface; other site 1286404002042 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286404002043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404002044 Walker A/P-loop; other site 1286404002045 ATP binding site [chemical binding]; other site 1286404002046 Q-loop/lid; other site 1286404002047 ABC transporter signature motif; other site 1286404002048 Walker B; other site 1286404002049 D-loop; other site 1286404002050 H-loop/switch region; other site 1286404002051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1286404002052 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286404002053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404002054 Walker A/P-loop; other site 1286404002055 ATP binding site [chemical binding]; other site 1286404002056 Q-loop/lid; other site 1286404002057 ABC transporter signature motif; other site 1286404002058 Walker B; other site 1286404002059 D-loop; other site 1286404002060 H-loop/switch region; other site 1286404002061 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286404002062 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1286404002063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002064 putative substrate translocation pore; other site 1286404002065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404002066 MarR family; Region: MarR; pfam01047 1286404002067 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286404002068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002069 putative substrate translocation pore; other site 1286404002070 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404002071 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404002072 DNA binding site [nucleotide binding] 1286404002073 domain linker motif; other site 1286404002074 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1286404002075 dimerization interface [polypeptide binding]; other site 1286404002076 ligand binding site [chemical binding]; other site 1286404002077 sodium binding site [ion binding]; other site 1286404002078 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286404002079 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1286404002080 substrate binding site [chemical binding]; other site 1286404002081 dimer interface [polypeptide binding]; other site 1286404002082 ATP binding site [chemical binding]; other site 1286404002083 D-ribose pyranase; Provisional; Region: PRK11797 1286404002084 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1286404002085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286404002086 Walker A/P-loop; other site 1286404002087 ATP binding site [chemical binding]; other site 1286404002088 Q-loop/lid; other site 1286404002089 ABC transporter signature motif; other site 1286404002090 Walker B; other site 1286404002091 D-loop; other site 1286404002092 H-loop/switch region; other site 1286404002093 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286404002094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286404002095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286404002096 TM-ABC transporter signature motif; other site 1286404002097 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1286404002098 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1286404002099 ligand binding site [chemical binding]; other site 1286404002100 dimerization interface [polypeptide binding]; other site 1286404002101 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1286404002102 active site 1286404002103 intersubunit interactions; other site 1286404002104 catalytic residue [active] 1286404002105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1286404002106 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1286404002107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404002109 putative substrate translocation pore; other site 1286404002110 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286404002111 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1286404002112 putative NAD(P) binding site [chemical binding]; other site 1286404002113 catalytic Zn binding site [ion binding]; other site 1286404002114 Ion channel; Region: Ion_trans_2; pfam07885 1286404002115 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1286404002116 Zn binding site [ion binding]; other site 1286404002117 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1286404002118 putative catalytic site [active] 1286404002119 metal binding site A [ion binding]; metal-binding site 1286404002120 phosphate binding site [ion binding]; other site 1286404002121 metal binding site C [ion binding]; metal-binding site 1286404002122 metal binding site B [ion binding]; metal-binding site 1286404002123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404002124 non-specific DNA binding site [nucleotide binding]; other site 1286404002125 salt bridge; other site 1286404002126 sequence-specific DNA binding site [nucleotide binding]; other site 1286404002127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404002128 non-specific DNA binding site [nucleotide binding]; other site 1286404002129 salt bridge; other site 1286404002130 sequence-specific DNA binding site [nucleotide binding]; other site 1286404002131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1286404002132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1286404002133 DNA binding residues [nucleotide binding] 1286404002134 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1286404002135 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 1286404002136 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404002137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404002138 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1286404002139 Walker A motif; other site 1286404002140 ATP binding site [chemical binding]; other site 1286404002141 Walker B motif; other site 1286404002142 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1286404002143 UPF0302 domain; Region: UPF0302; pfam08864 1286404002144 Homeodomain-like domain; Region: HTH_23; cl17451 1286404002145 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1286404002146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404002147 Prophage antirepressor [Transcription]; Region: COG3617 1286404002148 BRO family, N-terminal domain; Region: Bro-N; smart01040 1286404002149 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1286404002150 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1286404002151 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404002152 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286404002153 catalytic residues [active] 1286404002154 catalytic nucleophile [active] 1286404002155 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286404002156 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286404002157 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286404002158 Synaptic Site I dimer interface [polypeptide binding]; other site 1286404002159 DNA binding site [nucleotide binding] 1286404002160 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1286404002161 DNA-binding interface [nucleotide binding]; DNA binding site 1286404002162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1286404002163 Terminase-like family; Region: Terminase_6; pfam03237 1286404002164 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1286404002165 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1286404002166 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1286404002167 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1286404002168 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 1286404002169 H-type lectin domain; Region: H_lectin; pfam09458 1286404002170 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1286404002171 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1286404002172 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404002173 amidase catalytic site [active] 1286404002174 Zn binding residues [ion binding]; other site 1286404002175 substrate binding site [chemical binding]; other site 1286404002176 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404002177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1286404002178 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1286404002179 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404002180 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404002181 Helix-turn-helix domain; Region: HTH_36; pfam13730 1286404002182 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1286404002183 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1286404002184 dimer interface [polypeptide binding]; other site 1286404002185 active site 1286404002186 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286404002187 substrate binding site [chemical binding]; other site 1286404002188 catalytic residue [active] 1286404002189 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1286404002190 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404002191 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1286404002192 VanZ like family; Region: VanZ; pfam04892 1286404002193 RDD family; Region: RDD; pfam06271 1286404002194 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1286404002195 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1286404002196 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 1286404002197 homodimer interface [polypeptide binding]; other site 1286404002198 putative GKAP docking site [polypeptide binding]; other site 1286404002199 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404002200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404002201 dimer interface [polypeptide binding]; other site 1286404002202 putative CheW interface [polypeptide binding]; other site 1286404002203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1286404002204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1286404002205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404002206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404002207 non-specific DNA binding site [nucleotide binding]; other site 1286404002208 salt bridge; other site 1286404002209 sequence-specific DNA binding site [nucleotide binding]; other site 1286404002210 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1286404002211 active site 1286404002212 catalytic site [active] 1286404002213 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1286404002214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002215 putative substrate translocation pore; other site 1286404002216 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1286404002217 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 1286404002218 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1286404002219 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1286404002220 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1286404002221 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286404002222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404002223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404002224 non-specific DNA binding site [nucleotide binding]; other site 1286404002225 salt bridge; other site 1286404002226 sequence-specific DNA binding site [nucleotide binding]; other site 1286404002227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404002228 Coenzyme A binding pocket [chemical binding]; other site 1286404002229 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 1286404002230 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404002231 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404002232 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1286404002233 TrkA-N domain; Region: TrkA_N; pfam02254 1286404002234 TrkA-C domain; Region: TrkA_C; pfam02080 1286404002235 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1286404002236 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1286404002237 Subunit I/III interface [polypeptide binding]; other site 1286404002238 Subunit III/IV interface [polypeptide binding]; other site 1286404002239 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1286404002240 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1286404002241 D-pathway; other site 1286404002242 Putative ubiquinol binding site [chemical binding]; other site 1286404002243 Low-spin heme (heme b) binding site [chemical binding]; other site 1286404002244 Putative water exit pathway; other site 1286404002245 Binuclear center (heme o3/CuB) [ion binding]; other site 1286404002246 K-pathway; other site 1286404002247 Putative proton exit pathway; other site 1286404002248 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1286404002249 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1286404002250 S-methylmethionine transporter; Provisional; Region: PRK11387 1286404002251 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1286404002252 putative active site [active] 1286404002253 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286404002254 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1286404002255 metal binding site [ion binding]; metal-binding site 1286404002256 dimer interface [polypeptide binding]; other site 1286404002257 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1286404002258 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1286404002259 Na binding site [ion binding]; other site 1286404002260 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404002261 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1286404002262 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404002263 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404002264 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1286404002265 Nucleoside recognition; Region: Gate; pfam07670 1286404002266 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1286404002267 Nucleoside recognition; Region: Gate; pfam07670 1286404002268 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1286404002269 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1286404002270 G1 box; other site 1286404002271 GTP/Mg2+ binding site [chemical binding]; other site 1286404002272 Switch I region; other site 1286404002273 G2 box; other site 1286404002274 G3 box; other site 1286404002275 Switch II region; other site 1286404002276 G4 box; other site 1286404002277 G5 box; other site 1286404002278 FeoA domain; Region: FeoA; pfam04023 1286404002279 phosphate binding protein; Region: ptsS_2; TIGR02136 1286404002280 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286404002281 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1286404002282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002283 dimer interface [polypeptide binding]; other site 1286404002284 conserved gate region; other site 1286404002285 putative PBP binding loops; other site 1286404002286 ABC-ATPase subunit interface; other site 1286404002287 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1286404002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002289 dimer interface [polypeptide binding]; other site 1286404002290 conserved gate region; other site 1286404002291 putative PBP binding loops; other site 1286404002292 ABC-ATPase subunit interface; other site 1286404002293 AAA domain; Region: AAA_33; pfam13671 1286404002294 AAA domain; Region: AAA_17; pfam13207 1286404002295 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286404002296 Protein export membrane protein; Region: SecD_SecF; cl14618 1286404002297 FOG: CBS domain [General function prediction only]; Region: COG0517 1286404002298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1286404002299 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 1286404002300 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 1286404002301 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404002302 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404002303 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404002304 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404002305 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404002306 Putative transcription activator [Transcription]; Region: TenA; COG0819 1286404002307 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286404002308 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286404002309 Walker A/P-loop; other site 1286404002310 ATP binding site [chemical binding]; other site 1286404002311 Q-loop/lid; other site 1286404002312 ABC transporter signature motif; other site 1286404002313 Walker B; other site 1286404002314 D-loop; other site 1286404002315 H-loop/switch region; other site 1286404002316 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286404002317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002318 dimer interface [polypeptide binding]; other site 1286404002319 conserved gate region; other site 1286404002320 putative PBP binding loops; other site 1286404002321 ABC-ATPase subunit interface; other site 1286404002322 NMT1/THI5 like; Region: NMT1; pfam09084 1286404002323 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1286404002324 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1286404002325 thiamine phosphate binding site [chemical binding]; other site 1286404002326 active site 1286404002327 pyrophosphate binding site [ion binding]; other site 1286404002328 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1286404002329 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286404002330 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1286404002331 thiS-thiF/thiG interaction site; other site 1286404002332 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1286404002333 ThiS interaction site; other site 1286404002334 putative active site [active] 1286404002335 tetramer interface [polypeptide binding]; other site 1286404002336 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1286404002337 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286404002338 ATP binding site [chemical binding]; other site 1286404002339 substrate interface [chemical binding]; other site 1286404002340 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1286404002341 dimer interface [polypeptide binding]; other site 1286404002342 substrate binding site [chemical binding]; other site 1286404002343 ATP binding site [chemical binding]; other site 1286404002344 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1286404002345 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1286404002346 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404002347 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286404002348 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 1286404002349 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1286404002350 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1286404002351 Ligand Binding Site [chemical binding]; other site 1286404002352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404002354 putative substrate translocation pore; other site 1286404002355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404002356 MarR family; Region: MarR; pfam01047 1286404002357 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1286404002358 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1286404002359 active site 1286404002360 nucleophile elbow; other site 1286404002361 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286404002362 short chain dehydrogenase; Provisional; Region: PRK06701 1286404002363 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1286404002364 NAD binding site [chemical binding]; other site 1286404002365 metal binding site [ion binding]; metal-binding site 1286404002366 active site 1286404002367 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286404002368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286404002369 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286404002370 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1286404002371 putative substrate binding site [chemical binding]; other site 1286404002372 putative ATP binding site [chemical binding]; other site 1286404002373 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1286404002374 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1286404002375 substrate binding [chemical binding]; other site 1286404002376 active site 1286404002377 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1286404002378 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1286404002379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286404002380 active site turn [active] 1286404002381 phosphorylation site [posttranslational modification] 1286404002382 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404002383 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404002384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404002385 DNA binding site [nucleotide binding] 1286404002386 domain linker motif; other site 1286404002387 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1286404002388 dimerization interface [polypeptide binding]; other site 1286404002389 ligand binding site [chemical binding]; other site 1286404002390 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1286404002391 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404002392 catalytic residues [active] 1286404002393 putative disulfide oxidoreductase; Provisional; Region: PRK03113 1286404002394 YhdB-like protein; Region: YhdB; pfam14148 1286404002395 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 1286404002396 Spore germination protein; Region: Spore_permease; pfam03845 1286404002397 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404002398 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404002399 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404002400 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1286404002401 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1286404002402 putative FMN binding site [chemical binding]; other site 1286404002403 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1286404002404 SpoVR like protein; Region: SpoVR; pfam04293 1286404002405 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1286404002406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404002407 MarR family; Region: MarR_2; pfam12802 1286404002408 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 1286404002409 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 1286404002410 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1286404002411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404002412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404002413 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286404002414 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1286404002415 active site residue [active] 1286404002416 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1286404002417 putative homodimer interface [polypeptide binding]; other site 1286404002418 putative homotetramer interface [polypeptide binding]; other site 1286404002419 putative metal binding site [ion binding]; other site 1286404002420 putative homodimer-homodimer interface [polypeptide binding]; other site 1286404002421 putative allosteric switch controlling residues; other site 1286404002422 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1286404002423 CPxP motif; other site 1286404002424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404002425 active site residue [active] 1286404002426 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 1286404002427 active site residue [active] 1286404002428 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286404002429 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1286404002430 CPxP motif; other site 1286404002431 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404002432 active site residue [active] 1286404002433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404002434 active site residue [active] 1286404002435 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1286404002436 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404002437 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1286404002438 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1286404002439 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1286404002440 NADP binding site [chemical binding]; other site 1286404002441 dimer interface [polypeptide binding]; other site 1286404002442 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1286404002443 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286404002444 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1286404002445 PhoU domain; Region: PhoU; pfam01895 1286404002446 PhoU domain; Region: PhoU; pfam01895 1286404002447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404002449 putative substrate translocation pore; other site 1286404002450 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1286404002451 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1286404002452 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1286404002453 HTH domain; Region: HTH_11; pfam08279 1286404002454 Mga helix-turn-helix domain; Region: Mga; pfam05043 1286404002455 PRD domain; Region: PRD; pfam00874 1286404002456 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1286404002457 active site 1286404002458 P-loop; other site 1286404002459 phosphorylation site [posttranslational modification] 1286404002460 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286404002461 active site 1286404002462 phosphorylation site [posttranslational modification] 1286404002463 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1286404002464 active site 1286404002465 methionine cluster; other site 1286404002466 phosphorylation site [posttranslational modification] 1286404002467 metal binding site [ion binding]; metal-binding site 1286404002468 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286404002469 active site 1286404002470 P-loop; other site 1286404002471 phosphorylation site [posttranslational modification] 1286404002472 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1286404002473 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286404002474 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1286404002475 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1286404002476 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404002477 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404002478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1286404002479 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404002480 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404002481 FtsX-like permease family; Region: FtsX; pfam02687 1286404002482 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404002483 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404002484 Walker A/P-loop; other site 1286404002485 ATP binding site [chemical binding]; other site 1286404002486 Q-loop/lid; other site 1286404002487 ABC transporter signature motif; other site 1286404002488 Walker B; other site 1286404002489 D-loop; other site 1286404002490 H-loop/switch region; other site 1286404002491 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286404002492 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286404002493 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 1286404002494 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1286404002495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286404002496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404002497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002498 dimer interface [polypeptide binding]; other site 1286404002499 conserved gate region; other site 1286404002500 ABC-ATPase subunit interface; other site 1286404002501 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1286404002502 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1286404002503 dimanganese center [ion binding]; other site 1286404002504 CotJB protein; Region: CotJB; pfam12652 1286404002505 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404002506 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404002507 active site 1286404002508 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1286404002509 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1286404002510 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1286404002511 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1286404002512 putative DNA binding site [nucleotide binding]; other site 1286404002513 putative homodimer interface [polypeptide binding]; other site 1286404002514 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1286404002515 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404002516 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404002517 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1286404002518 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1286404002519 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1286404002520 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404002521 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1286404002522 active site 1286404002523 metal binding site [ion binding]; metal-binding site 1286404002524 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404002525 Interdomain contacts; other site 1286404002526 Cytokine receptor motif; other site 1286404002527 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1286404002528 amino acid transporter; Region: 2A0306; TIGR00909 1286404002529 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1286404002530 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404002531 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404002532 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286404002533 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286404002534 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286404002535 putative active site [active] 1286404002536 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1286404002537 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1286404002538 putative active site [active] 1286404002539 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286404002540 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1286404002541 active site turn [active] 1286404002542 phosphorylation site [posttranslational modification] 1286404002543 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404002544 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1286404002545 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1286404002546 DoxX; Region: DoxX; pfam07681 1286404002547 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1286404002548 hypothetical protein; Provisional; Region: PRK06770 1286404002549 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404002550 EamA-like transporter family; Region: EamA; pfam00892 1286404002551 EamA-like transporter family; Region: EamA; pfam00892 1286404002552 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286404002553 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1286404002554 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404002555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404002556 Coenzyme A binding pocket [chemical binding]; other site 1286404002557 short chain dehydrogenase; Provisional; Region: PRK06138 1286404002558 classical (c) SDRs; Region: SDR_c; cd05233 1286404002559 NAD(P) binding site [chemical binding]; other site 1286404002560 active site 1286404002561 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404002562 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1286404002563 DNA binding residues [nucleotide binding] 1286404002564 putative dimer interface [polypeptide binding]; other site 1286404002565 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404002566 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404002567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404002568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404002569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404002570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002572 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404002573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404002574 dimerization interface [polypeptide binding]; other site 1286404002575 putative DNA binding site [nucleotide binding]; other site 1286404002576 putative Zn2+ binding site [ion binding]; other site 1286404002577 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1286404002578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404002579 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1286404002580 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1286404002581 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1286404002582 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1286404002583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404002584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002585 putative substrate translocation pore; other site 1286404002586 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1286404002587 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1286404002588 proposed catalytic triad [active] 1286404002589 conserved cys residue [active] 1286404002590 hydroperoxidase II; Provisional; Region: katE; PRK11249 1286404002591 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1286404002592 tetramer interface [polypeptide binding]; other site 1286404002593 heme binding pocket [chemical binding]; other site 1286404002594 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1286404002595 domain interactions; other site 1286404002596 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1286404002597 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1286404002598 Spore germination protein; Region: Spore_permease; cl17796 1286404002599 glutamate racemase; Provisional; Region: PRK00865 1286404002600 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1286404002601 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1286404002602 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1286404002603 tetrameric interface [polypeptide binding]; other site 1286404002604 activator binding site; other site 1286404002605 NADP binding site [chemical binding]; other site 1286404002606 substrate binding site [chemical binding]; other site 1286404002607 catalytic residues [active] 1286404002608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404002609 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1286404002610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404002611 Walker A/P-loop; other site 1286404002612 ATP binding site [chemical binding]; other site 1286404002613 Q-loop/lid; other site 1286404002614 ABC transporter signature motif; other site 1286404002615 Walker B; other site 1286404002616 D-loop; other site 1286404002617 H-loop/switch region; other site 1286404002618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404002619 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1286404002620 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1286404002621 Walker A/P-loop; other site 1286404002622 ATP binding site [chemical binding]; other site 1286404002623 Q-loop/lid; other site 1286404002624 ABC transporter signature motif; other site 1286404002625 Walker B; other site 1286404002626 D-loop; other site 1286404002627 H-loop/switch region; other site 1286404002628 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286404002629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404002630 substrate binding pocket [chemical binding]; other site 1286404002631 membrane-bound complex binding site; other site 1286404002632 hinge residues; other site 1286404002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002634 dimer interface [polypeptide binding]; other site 1286404002635 conserved gate region; other site 1286404002636 putative PBP binding loops; other site 1286404002637 ABC-ATPase subunit interface; other site 1286404002638 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286404002639 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286404002640 Walker A/P-loop; other site 1286404002641 ATP binding site [chemical binding]; other site 1286404002642 Q-loop/lid; other site 1286404002643 ABC transporter signature motif; other site 1286404002644 Walker B; other site 1286404002645 D-loop; other site 1286404002646 H-loop/switch region; other site 1286404002647 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404002648 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1286404002649 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1286404002650 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1286404002651 hypothetical protein; Provisional; Region: PRK13676 1286404002652 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1286404002653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404002654 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404002655 Probable transposase; Region: OrfB_IS605; pfam01385 1286404002656 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404002657 acetolactate synthase; Reviewed; Region: PRK08617 1286404002658 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286404002659 PYR/PP interface [polypeptide binding]; other site 1286404002660 dimer interface [polypeptide binding]; other site 1286404002661 TPP binding site [chemical binding]; other site 1286404002662 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286404002663 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1286404002664 TPP-binding site [chemical binding]; other site 1286404002665 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1286404002666 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1286404002667 active site 1286404002668 DNA binding site [nucleotide binding] 1286404002669 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1286404002670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1286404002671 active site 1286404002672 motif I; other site 1286404002673 motif II; other site 1286404002674 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286404002675 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1286404002676 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1286404002677 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002678 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002679 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002680 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002681 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002682 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002683 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404002684 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404002685 amidase catalytic site [active] 1286404002686 Zn binding residues [ion binding]; other site 1286404002687 substrate binding site [chemical binding]; other site 1286404002688 S-layer homology domain; Region: SLH; pfam00395 1286404002689 S-layer homology domain; Region: SLH; pfam00395 1286404002690 S-layer homology domain; Region: SLH; pfam00395 1286404002691 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1286404002692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404002693 FeS/SAM binding site; other site 1286404002694 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1286404002695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286404002696 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1286404002697 acyl-activating enzyme (AAE) consensus motif; other site 1286404002698 acyl-activating enzyme (AAE) consensus motif; other site 1286404002699 putative AMP binding site [chemical binding]; other site 1286404002700 putative active site [active] 1286404002701 putative CoA binding site [chemical binding]; other site 1286404002702 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1286404002703 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286404002704 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1286404002705 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1286404002706 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1286404002707 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1286404002708 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1286404002709 S-layer homology domain; Region: SLH; pfam00395 1286404002710 S-layer homology domain; Region: SLH; pfam00395 1286404002711 S-layer homology domain; Region: SLH; pfam00395 1286404002712 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1286404002713 O-Antigen ligase; Region: Wzy_C; cl04850 1286404002714 enoyl-CoA hydratase; Provisional; Region: PRK07659 1286404002715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286404002716 substrate binding site [chemical binding]; other site 1286404002717 oxyanion hole (OAH) forming residues; other site 1286404002718 trimer interface [polypeptide binding]; other site 1286404002719 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 1286404002720 metal binding site [ion binding]; metal-binding site 1286404002721 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1286404002722 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1286404002723 putative oligomer interface [polypeptide binding]; other site 1286404002724 putative active site [active] 1286404002725 metal binding site [ion binding]; metal-binding site 1286404002726 S-layer homology domain; Region: SLH; pfam00395 1286404002727 S-layer homology domain; Region: SLH; pfam00395 1286404002728 S-layer homology domain; Region: SLH; pfam00395 1286404002729 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286404002730 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286404002731 active site 1286404002732 metal binding site [ion binding]; metal-binding site 1286404002733 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 1286404002734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404002735 S-adenosylmethionine binding site [chemical binding]; other site 1286404002736 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1286404002737 ornithine cyclodeaminase; Validated; Region: PRK08618 1286404002738 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286404002739 NAD(P) binding site [chemical binding]; other site 1286404002740 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1286404002741 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1286404002742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286404002743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002744 dimer interface [polypeptide binding]; other site 1286404002745 conserved gate region; other site 1286404002746 putative PBP binding loops; other site 1286404002747 ABC-ATPase subunit interface; other site 1286404002748 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404002749 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286404002750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404002751 dimer interface [polypeptide binding]; other site 1286404002752 conserved gate region; other site 1286404002753 putative PBP binding loops; other site 1286404002754 ABC-ATPase subunit interface; other site 1286404002755 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286404002756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404002757 Walker A/P-loop; other site 1286404002758 ATP binding site [chemical binding]; other site 1286404002759 Q-loop/lid; other site 1286404002760 ABC transporter signature motif; other site 1286404002761 Walker B; other site 1286404002762 D-loop; other site 1286404002763 H-loop/switch region; other site 1286404002764 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286404002765 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1286404002766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404002767 Walker A/P-loop; other site 1286404002768 ATP binding site [chemical binding]; other site 1286404002769 Q-loop/lid; other site 1286404002770 ABC transporter signature motif; other site 1286404002771 Walker B; other site 1286404002772 D-loop; other site 1286404002773 H-loop/switch region; other site 1286404002774 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1286404002775 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1286404002776 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1286404002777 catalytic residues [active] 1286404002778 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286404002779 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1286404002780 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1286404002781 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1286404002782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002783 putative substrate translocation pore; other site 1286404002784 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1286404002785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404002786 putative active site [active] 1286404002787 heme pocket [chemical binding]; other site 1286404002788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404002789 ATP binding site [chemical binding]; other site 1286404002790 Mg2+ binding site [ion binding]; other site 1286404002791 G-X-G motif; other site 1286404002792 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1286404002793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404002794 active site 1286404002795 phosphorylation site [posttranslational modification] 1286404002796 intermolecular recognition site; other site 1286404002797 dimerization interface [polypeptide binding]; other site 1286404002798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1286404002799 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1286404002800 active site 1286404002801 8-oxo-dGMP binding site [chemical binding]; other site 1286404002802 nudix motif; other site 1286404002803 metal binding site [ion binding]; metal-binding site 1286404002804 PLD-like domain; Region: PLDc_2; pfam13091 1286404002805 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1286404002806 putative homodimer interface [polypeptide binding]; other site 1286404002807 putative active site [active] 1286404002808 catalytic site [active] 1286404002809 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286404002810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404002811 ATP binding site [chemical binding]; other site 1286404002812 putative Mg++ binding site [ion binding]; other site 1286404002813 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286404002814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404002815 nucleotide binding region [chemical binding]; other site 1286404002816 ATP-binding site [chemical binding]; other site 1286404002817 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1286404002818 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404002819 replicative DNA helicase; Provisional; Region: PRK06749 1286404002820 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1286404002821 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1286404002822 Walker A motif; other site 1286404002823 ATP binding site [chemical binding]; other site 1286404002824 Walker B motif; other site 1286404002825 DNA binding loops [nucleotide binding] 1286404002826 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1286404002827 Predicted transcriptional regulators [Transcription]; Region: COG1378 1286404002828 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1286404002829 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1286404002830 C-terminal domain interface [polypeptide binding]; other site 1286404002831 sugar binding site [chemical binding]; other site 1286404002832 hypothetical protein; Provisional; Region: PRK10621 1286404002833 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404002834 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404002835 EamA-like transporter family; Region: EamA; pfam00892 1286404002836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404002837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404002838 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1286404002839 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286404002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002841 putative substrate translocation pore; other site 1286404002842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002843 hypothetical protein; Provisional; Region: PRK06770 1286404002844 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1286404002845 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1286404002846 active site 1286404002847 catalytic site [active] 1286404002848 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404002849 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404002850 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 1286404002851 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1286404002852 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1286404002853 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1286404002854 CGNR zinc finger; Region: zf-CGNR; pfam11706 1286404002855 HPP family; Region: HPP; pfam04982 1286404002856 YmzC-like protein; Region: YmzC; pfam14157 1286404002857 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286404002858 MarR family; Region: MarR_2; pfam12802 1286404002859 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1286404002860 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1286404002861 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404002862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404002863 putative substrate translocation pore; other site 1286404002864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404002865 putative DNA binding site [nucleotide binding]; other site 1286404002866 dimerization interface [polypeptide binding]; other site 1286404002867 putative Zn2+ binding site [ion binding]; other site 1286404002868 VanZ like family; Region: VanZ; pfam04892 1286404002869 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 1286404002870 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1286404002871 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1286404002872 dihydroxyacetone kinase; Provisional; Region: PRK14479 1286404002873 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1286404002874 DAK2 domain; Region: Dak2; pfam02734 1286404002875 Bacterial SH3 domain; Region: SH3_3; cl17532 1286404002876 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1286404002877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404002878 non-specific DNA binding site [nucleotide binding]; other site 1286404002879 salt bridge; other site 1286404002880 sequence-specific DNA binding site [nucleotide binding]; other site 1286404002881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404002882 transposase/IS protein; Provisional; Region: PRK09183 1286404002883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404002884 Walker A motif; other site 1286404002885 ATP binding site [chemical binding]; other site 1286404002886 Walker B motif; other site 1286404002887 arginine finger; other site 1286404002888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404002889 Integrase core domain; Region: rve; pfam00665 1286404002890 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404002891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404002892 TPR motif; other site 1286404002893 binding surface 1286404002894 S-layer homology domain; Region: SLH; pfam00395 1286404002895 S-layer homology domain; Region: SLH; pfam00395 1286404002896 S-layer homology domain; Region: SLH; pfam00395 1286404002897 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286404002898 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404002899 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404002900 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1286404002901 Putative zinc-finger; Region: zf-HC2; pfam13490 1286404002902 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1286404002903 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1286404002904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404002905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404002906 DNA binding residues [nucleotide binding] 1286404002907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404002908 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1286404002909 Heat induced stress protein YflT; Region: YflT; pfam11181 1286404002910 Predicted membrane protein [Function unknown]; Region: COG2261 1286404002911 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1286404002912 anti sigma factor interaction site; other site 1286404002913 regulatory phosphorylation site [posttranslational modification]; other site 1286404002914 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1286404002915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404002916 ATP binding site [chemical binding]; other site 1286404002917 Mg2+ binding site [ion binding]; other site 1286404002918 G-X-G motif; other site 1286404002919 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 1286404002920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404002921 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1286404002922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404002923 DNA binding residues [nucleotide binding] 1286404002924 Ferritin-like domain; Region: Ferritin; pfam00210 1286404002925 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1286404002926 dinuclear metal binding motif [ion binding]; other site 1286404002927 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1286404002928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404002929 active site 1286404002930 phosphorylation site [posttranslational modification] 1286404002931 intermolecular recognition site; other site 1286404002932 dimerization interface [polypeptide binding]; other site 1286404002933 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1286404002934 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1286404002935 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1286404002936 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1286404002937 CHASE3 domain; Region: CHASE3; pfam05227 1286404002938 GAF domain; Region: GAF_2; pfam13185 1286404002939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404002940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404002941 dimer interface [polypeptide binding]; other site 1286404002942 phosphorylation site [posttranslational modification] 1286404002943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404002944 ATP binding site [chemical binding]; other site 1286404002945 Mg2+ binding site [ion binding]; other site 1286404002946 G-X-G motif; other site 1286404002947 Response regulator receiver domain; Region: Response_reg; pfam00072 1286404002948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404002949 active site 1286404002950 phosphorylation site [posttranslational modification] 1286404002951 intermolecular recognition site; other site 1286404002952 dimerization interface [polypeptide binding]; other site 1286404002953 regulatory protein interface [polypeptide binding]; other site 1286404002954 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1286404002955 regulatory phosphorylation site [posttranslational modification]; other site 1286404002956 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 1286404002957 hypothetical protein; Provisional; Region: PRK12856 1286404002958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404002959 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404002960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404002961 Transposase; Region: HTH_Tnp_1; cl17663 1286404002962 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404002963 putative transposase OrfB; Reviewed; Region: PHA02517 1286404002964 HTH-like domain; Region: HTH_21; pfam13276 1286404002965 Integrase core domain; Region: rve; pfam00665 1286404002966 Integrase core domain; Region: rve_2; pfam13333 1286404002967 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404002968 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404002969 putative active site [active] 1286404002970 putative NTP binding site [chemical binding]; other site 1286404002971 putative nucleic acid binding site [nucleotide binding]; other site 1286404002972 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404002973 active site 1286404002974 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404002975 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1286404002976 NADP binding site [chemical binding]; other site 1286404002977 dimer interface [polypeptide binding]; other site 1286404002978 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1286404002979 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1286404002980 active site 1286404002981 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1286404002982 YhzD-like protein; Region: YhzD; pfam14120 1286404002983 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1286404002984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404002985 active site 1286404002986 metal binding site [ion binding]; metal-binding site 1286404002987 DNA binding site [nucleotide binding] 1286404002988 AAA domain; Region: AAA_27; pfam13514 1286404002989 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1286404002990 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1286404002991 generic binding surface II; other site 1286404002992 generic binding surface I; other site 1286404002993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404002994 Zn2+ binding site [ion binding]; other site 1286404002995 Mg2+ binding site [ion binding]; other site 1286404002996 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 1286404002997 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286404002998 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286404002999 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404003000 Zn binding site [ion binding]; other site 1286404003001 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286404003002 Zn binding site [ion binding]; other site 1286404003003 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286404003004 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404003005 Zn binding site [ion binding]; other site 1286404003006 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286404003007 Zn binding site [ion binding]; other site 1286404003008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404003009 TPR motif; other site 1286404003010 binding surface 1286404003011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404003012 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286404003013 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1286404003014 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1286404003015 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1286404003016 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1286404003017 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1286404003018 Cupin; Region: Cupin_1; smart00835 1286404003019 Cupin; Region: Cupin_1; smart00835 1286404003020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404003021 non-specific DNA binding site [nucleotide binding]; other site 1286404003022 salt bridge; other site 1286404003023 sequence-specific DNA binding site [nucleotide binding]; other site 1286404003024 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1286404003025 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1286404003026 amphipathic channel; other site 1286404003027 Asn-Pro-Ala signature motifs; other site 1286404003028 glycerol kinase; Provisional; Region: glpK; PRK00047 1286404003029 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1286404003030 N- and C-terminal domain interface [polypeptide binding]; other site 1286404003031 active site 1286404003032 MgATP binding site [chemical binding]; other site 1286404003033 catalytic site [active] 1286404003034 metal binding site [ion binding]; metal-binding site 1286404003035 glycerol binding site [chemical binding]; other site 1286404003036 homotetramer interface [polypeptide binding]; other site 1286404003037 homodimer interface [polypeptide binding]; other site 1286404003038 FBP binding site [chemical binding]; other site 1286404003039 protein IIAGlc interface [polypeptide binding]; other site 1286404003040 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1286404003041 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404003042 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1286404003043 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1286404003044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404003045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404003046 DNA binding residues [nucleotide binding] 1286404003047 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 1286404003048 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404003049 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1286404003050 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1286404003051 Part of AAA domain; Region: AAA_19; pfam13245 1286404003052 Family description; Region: UvrD_C_2; pfam13538 1286404003053 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1286404003054 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286404003055 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1286404003056 transcriptional regulator Hpr; Provisional; Region: PRK13777 1286404003057 MarR family; Region: MarR; pfam01047 1286404003058 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1286404003059 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1286404003060 HIT family signature motif; other site 1286404003061 catalytic residue [active] 1286404003062 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404003063 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404003064 Walker A/P-loop; other site 1286404003065 ATP binding site [chemical binding]; other site 1286404003066 Q-loop/lid; other site 1286404003067 ABC transporter signature motif; other site 1286404003068 Walker B; other site 1286404003069 D-loop; other site 1286404003070 H-loop/switch region; other site 1286404003071 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1286404003072 EcsC protein family; Region: EcsC; pfam12787 1286404003073 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1286404003074 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1286404003075 nucleophilic elbow; other site 1286404003076 catalytic triad; other site 1286404003077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404003078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404003079 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1286404003080 Predicted membrane protein [Function unknown]; Region: COG3428 1286404003081 Bacterial PH domain; Region: DUF304; pfam03703 1286404003082 Bacterial PH domain; Region: DUF304; cl01348 1286404003083 Bacterial PH domain; Region: DUF304; pfam03703 1286404003084 Protein of unknown function (DUF975); Region: DUF975; cl10504 1286404003085 Protein of unknown function (DUF975); Region: DUF975; cl10504 1286404003086 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1286404003087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404003088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404003089 Collagen binding domain; Region: Collagen_bind; pfam05737 1286404003090 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404003091 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003092 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003093 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003094 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1286404003095 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003096 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003097 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003098 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003099 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003100 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003101 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003102 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003103 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003104 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404003105 Cornifin (SPRR) family; Region: Cornifin; pfam02389 1286404003106 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1286404003107 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1286404003108 classical (c) SDRs; Region: SDR_c; cd05233 1286404003109 NAD(P) binding site [chemical binding]; other site 1286404003110 active site 1286404003111 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404003112 EamA-like transporter family; Region: EamA; pfam00892 1286404003113 EamA-like transporter family; Region: EamA; pfam00892 1286404003114 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1286404003115 Bacterial PH domain; Region: DUF304; pfam03703 1286404003116 Bacterial PH domain; Region: DUF304; pfam03703 1286404003117 Bacterial PH domain; Region: DUF304; pfam03703 1286404003118 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1286404003119 Transglycosylase; Region: Transgly; pfam00912 1286404003120 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1286404003121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404003122 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1286404003123 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1286404003124 substrate binding site [chemical binding]; other site 1286404003125 active site 1286404003126 ferrochelatase; Provisional; Region: PRK12435 1286404003127 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1286404003128 C-terminal domain interface [polypeptide binding]; other site 1286404003129 active site 1286404003130 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1286404003131 active site 1286404003132 N-terminal domain interface [polypeptide binding]; other site 1286404003133 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1286404003134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404003135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404003136 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 1286404003137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 1286404003138 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1286404003139 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1286404003140 generic binding surface I; other site 1286404003141 generic binding surface II; other site 1286404003142 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1286404003143 putative active site [active] 1286404003144 putative catalytic site [active] 1286404003145 putative Mg binding site IVb [ion binding]; other site 1286404003146 putative phosphate binding site [ion binding]; other site 1286404003147 putative DNA binding site [nucleotide binding]; other site 1286404003148 putative Mg binding site IVa [ion binding]; other site 1286404003149 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1286404003150 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1286404003151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404003152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404003153 Predicted membrane protein [Function unknown]; Region: COG1511 1286404003154 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1286404003155 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1286404003156 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1286404003157 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1286404003158 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1286404003159 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 1286404003160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404003161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404003162 Coenzyme A binding pocket [chemical binding]; other site 1286404003163 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404003164 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404003165 DNA binding site [nucleotide binding] 1286404003166 domain linker motif; other site 1286404003167 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1286404003168 putative dimerization interface [polypeptide binding]; other site 1286404003169 putative ligand binding site [chemical binding]; other site 1286404003170 YhfH-like protein; Region: YhfH; pfam14149 1286404003171 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1286404003172 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1286404003173 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1286404003174 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1286404003175 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1286404003176 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1286404003177 acyl-activating enzyme (AAE) consensus motif; other site 1286404003178 putative AMP binding site [chemical binding]; other site 1286404003179 putative active site [active] 1286404003180 putative CoA binding site [chemical binding]; other site 1286404003181 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286404003182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404003183 substrate binding pocket [chemical binding]; other site 1286404003184 membrane-bound complex binding site; other site 1286404003185 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286404003186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003187 dimer interface [polypeptide binding]; other site 1286404003188 conserved gate region; other site 1286404003189 putative PBP binding loops; other site 1286404003190 ABC-ATPase subunit interface; other site 1286404003191 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1286404003192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003193 dimer interface [polypeptide binding]; other site 1286404003194 conserved gate region; other site 1286404003195 putative PBP binding loops; other site 1286404003196 ABC-ATPase subunit interface; other site 1286404003197 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1286404003198 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1286404003199 Walker A/P-loop; other site 1286404003200 ATP binding site [chemical binding]; other site 1286404003201 Q-loop/lid; other site 1286404003202 ABC transporter signature motif; other site 1286404003203 Walker B; other site 1286404003204 D-loop; other site 1286404003205 H-loop/switch region; other site 1286404003206 TOBE-like domain; Region: TOBE_3; pfam12857 1286404003207 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1286404003208 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1286404003209 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404003210 putative active site [active] 1286404003211 putative metal binding site [ion binding]; other site 1286404003212 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1286404003213 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404003214 Zn2+ binding site [ion binding]; other site 1286404003215 Mg2+ binding site [ion binding]; other site 1286404003216 Putative zinc-finger; Region: zf-HC2; pfam13490 1286404003217 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1286404003218 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1286404003219 RNA polymerase sigma factor; Provisional; Region: PRK12541 1286404003220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404003221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404003222 DNA binding residues [nucleotide binding] 1286404003223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404003224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286404003225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1286404003227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404003228 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404003229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404003230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404003231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404003232 dimer interface [polypeptide binding]; other site 1286404003233 phosphorylation site [posttranslational modification] 1286404003234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404003235 ATP binding site [chemical binding]; other site 1286404003236 Mg2+ binding site [ion binding]; other site 1286404003237 G-X-G motif; other site 1286404003238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404003239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404003240 active site 1286404003241 phosphorylation site [posttranslational modification] 1286404003242 intermolecular recognition site; other site 1286404003243 dimerization interface [polypeptide binding]; other site 1286404003244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404003245 DNA binding site [nucleotide binding] 1286404003246 CAAX protease self-immunity; Region: Abi; pfam02517 1286404003247 Peptidase family M48; Region: Peptidase_M48; pfam01435 1286404003248 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1286404003249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404003250 dimerization interface [polypeptide binding]; other site 1286404003251 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404003252 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404003253 dimer interface [polypeptide binding]; other site 1286404003254 putative CheW interface [polypeptide binding]; other site 1286404003255 S-layer homology domain; Region: SLH; pfam00395 1286404003256 S-layer homology domain; Region: SLH; pfam00395 1286404003257 S-layer homology domain; Region: SLH; pfam00395 1286404003258 S-layer homology domain; Region: SLH; pfam00395 1286404003259 S-layer homology domain; Region: SLH; pfam00395 1286404003260 S-layer homology domain; Region: SLH; pfam00395 1286404003261 malate synthase A; Region: malate_syn_A; TIGR01344 1286404003262 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1286404003263 active site 1286404003264 isocitrate lyase; Provisional; Region: PRK15063 1286404003265 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1286404003266 tetramer interface [polypeptide binding]; other site 1286404003267 active site 1286404003268 Mg2+/Mn2+ binding site [ion binding]; other site 1286404003269 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404003270 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286404003271 active site 1286404003272 substrate binding site [chemical binding]; other site 1286404003273 ATP binding site [chemical binding]; other site 1286404003274 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404003275 DNA-binding site [nucleotide binding]; DNA binding site 1286404003276 RNA-binding motif; other site 1286404003277 ComK protein; Region: ComK; pfam06338 1286404003278 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1286404003279 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404003280 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286404003281 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404003282 Catalytic site [active] 1286404003283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404003284 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1286404003285 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1286404003286 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1286404003287 Part of AAA domain; Region: AAA_19; pfam13245 1286404003288 Family description; Region: UvrD_C_2; pfam13538 1286404003289 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1286404003290 hypothetical protein; Provisional; Region: PRK07758 1286404003291 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1286404003292 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1286404003293 Spore germination protein GerPC; Region: GerPC; pfam10737 1286404003294 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1286404003295 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1286404003296 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404003297 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1286404003298 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1286404003299 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1286404003300 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404003301 inhibitor-cofactor binding pocket; inhibition site 1286404003302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404003303 catalytic residue [active] 1286404003304 hypothetical protein; Provisional; Region: PRK13673 1286404003305 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1286404003306 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286404003307 active site 1286404003308 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1286404003309 dimer interface [polypeptide binding]; other site 1286404003310 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286404003311 Ligand Binding Site [chemical binding]; other site 1286404003312 Molecular Tunnel; other site 1286404003313 ferrochelatase; Provisional; Region: PRK12435 1286404003314 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1286404003315 C-terminal domain interface [polypeptide binding]; other site 1286404003316 active site 1286404003317 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1286404003318 active site 1286404003319 N-terminal domain interface [polypeptide binding]; other site 1286404003320 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1286404003321 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1286404003322 tetramer interface [polypeptide binding]; other site 1286404003323 heme binding pocket [chemical binding]; other site 1286404003324 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1286404003325 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1286404003326 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1286404003327 active site 1286404003328 catalytic site [active] 1286404003329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404003330 non-specific DNA binding site [nucleotide binding]; other site 1286404003331 salt bridge; other site 1286404003332 sequence-specific DNA binding site [nucleotide binding]; other site 1286404003333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404003334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1286404003335 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1286404003336 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1286404003337 S1 domain; Region: S1_2; pfam13509 1286404003338 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1286404003339 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286404003340 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404003341 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404003342 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404003343 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1286404003344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404003345 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404003346 active site 1286404003347 motif I; other site 1286404003348 motif II; other site 1286404003349 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286404003350 YjzC-like protein; Region: YjzC; pfam14168 1286404003351 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1286404003352 Clp amino terminal domain; Region: Clp_N; pfam02861 1286404003353 Clp amino terminal domain; Region: Clp_N; pfam02861 1286404003354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404003355 Walker A motif; other site 1286404003356 ATP binding site [chemical binding]; other site 1286404003357 Walker B motif; other site 1286404003358 arginine finger; other site 1286404003359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404003360 Walker A motif; other site 1286404003361 ATP binding site [chemical binding]; other site 1286404003362 Walker B motif; other site 1286404003363 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1286404003364 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1286404003365 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404003366 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404003367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404003368 NAD(P) binding site [chemical binding]; other site 1286404003369 active site 1286404003370 ComZ; Region: ComZ; pfam10815 1286404003371 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1286404003372 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1286404003373 dimer interface [polypeptide binding]; other site 1286404003374 active site 1286404003375 CoA binding pocket [chemical binding]; other site 1286404003376 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1286404003377 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1286404003378 dimer interface [polypeptide binding]; other site 1286404003379 active site 1286404003380 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1286404003381 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1286404003382 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1286404003383 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1286404003384 active site 1286404003385 HIGH motif; other site 1286404003386 dimer interface [polypeptide binding]; other site 1286404003387 KMSKS motif; other site 1286404003388 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1286404003389 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404003390 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404003391 peptide binding site [polypeptide binding]; other site 1286404003392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1286404003393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003394 dimer interface [polypeptide binding]; other site 1286404003395 conserved gate region; other site 1286404003396 putative PBP binding loops; other site 1286404003397 ABC-ATPase subunit interface; other site 1286404003398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404003399 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1286404003400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003401 dimer interface [polypeptide binding]; other site 1286404003402 conserved gate region; other site 1286404003403 putative PBP binding loops; other site 1286404003404 ABC-ATPase subunit interface; other site 1286404003405 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1286404003406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404003407 Walker A/P-loop; other site 1286404003408 ATP binding site [chemical binding]; other site 1286404003409 Q-loop/lid; other site 1286404003410 ABC transporter signature motif; other site 1286404003411 Walker B; other site 1286404003412 D-loop; other site 1286404003413 H-loop/switch region; other site 1286404003414 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286404003415 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1286404003416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1286404003417 Walker A/P-loop; other site 1286404003418 ATP binding site [chemical binding]; other site 1286404003419 Q-loop/lid; other site 1286404003420 ABC transporter signature motif; other site 1286404003421 Walker B; other site 1286404003422 D-loop; other site 1286404003423 H-loop/switch region; other site 1286404003424 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1286404003425 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1286404003426 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1286404003427 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404003428 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404003429 peptide binding site [polypeptide binding]; other site 1286404003430 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1286404003431 ArsC family; Region: ArsC; pfam03960 1286404003432 putative catalytic residues [active] 1286404003433 thiol/disulfide switch; other site 1286404003434 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1286404003435 adaptor protein; Provisional; Region: PRK02315 1286404003436 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1286404003437 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1286404003438 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1286404003439 putative active site [active] 1286404003440 catalytic site [active] 1286404003441 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1286404003442 putative active site [active] 1286404003443 catalytic site [active] 1286404003444 Competence protein CoiA-like family; Region: CoiA; cl11541 1286404003445 oligoendopeptidase F; Region: pepF; TIGR00181 1286404003446 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1286404003447 active site 1286404003448 Zn binding site [ion binding]; other site 1286404003449 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1286404003450 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1286404003451 catalytic residues [active] 1286404003452 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1286404003453 apolar tunnel; other site 1286404003454 heme binding site [chemical binding]; other site 1286404003455 dimerization interface [polypeptide binding]; other site 1286404003456 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1286404003457 putative active site [active] 1286404003458 putative metal binding residues [ion binding]; other site 1286404003459 signature motif; other site 1286404003460 putative triphosphate binding site [ion binding]; other site 1286404003461 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1286404003462 synthetase active site [active] 1286404003463 NTP binding site [chemical binding]; other site 1286404003464 metal binding site [ion binding]; metal-binding site 1286404003465 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1286404003466 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1286404003467 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286404003468 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286404003469 active site 1286404003470 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1286404003471 trimer interface [polypeptide binding]; other site 1286404003472 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1286404003473 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1286404003474 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1286404003475 active site 1286404003476 metal binding site [ion binding]; metal-binding site 1286404003477 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1286404003478 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286404003479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404003480 active site 1286404003481 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404003482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404003483 S-adenosylmethionine binding site [chemical binding]; other site 1286404003484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286404003485 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1286404003486 putative metal binding site; other site 1286404003487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404003488 binding surface 1286404003489 TPR motif; other site 1286404003490 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404003491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404003492 S-adenosylmethionine binding site [chemical binding]; other site 1286404003493 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1286404003494 catalytic residues [active] 1286404003495 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1286404003496 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1286404003497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404003498 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286404003499 active site 1286404003500 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1286404003501 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1286404003502 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1286404003503 NAD binding site [chemical binding]; other site 1286404003504 substrate binding site [chemical binding]; other site 1286404003505 homodimer interface [polypeptide binding]; other site 1286404003506 active site 1286404003507 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1286404003508 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1286404003509 NADP binding site [chemical binding]; other site 1286404003510 active site 1286404003511 putative substrate binding site [chemical binding]; other site 1286404003512 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1286404003513 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1286404003514 NAD binding site [chemical binding]; other site 1286404003515 homotetramer interface [polypeptide binding]; other site 1286404003516 homodimer interface [polypeptide binding]; other site 1286404003517 substrate binding site [chemical binding]; other site 1286404003518 active site 1286404003519 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1286404003520 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1286404003521 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1286404003522 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1286404003523 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1286404003524 Part of AAA domain; Region: AAA_19; pfam13245 1286404003525 Family description; Region: UvrD_C_2; pfam13538 1286404003526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404003527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404003528 Coenzyme A binding pocket [chemical binding]; other site 1286404003529 hypothetical protein; Provisional; Region: PRK13679 1286404003530 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286404003531 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286404003532 Putative esterase; Region: Esterase; pfam00756 1286404003533 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404003534 EamA-like transporter family; Region: EamA; pfam00892 1286404003535 EamA-like transporter family; Region: EamA; pfam00892 1286404003536 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1286404003537 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1286404003538 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1286404003539 Na binding site [ion binding]; other site 1286404003540 anthranilate synthase component I; Provisional; Region: PRK13570 1286404003541 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1286404003542 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286404003543 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1286404003544 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1286404003545 glutamine binding [chemical binding]; other site 1286404003546 catalytic triad [active] 1286404003547 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1286404003548 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286404003549 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286404003550 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1286404003551 active site 1286404003552 ribulose/triose binding site [chemical binding]; other site 1286404003553 phosphate binding site [ion binding]; other site 1286404003554 substrate (anthranilate) binding pocket [chemical binding]; other site 1286404003555 product (indole) binding pocket [chemical binding]; other site 1286404003556 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1286404003557 active site 1286404003558 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1286404003559 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1286404003560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404003561 catalytic residue [active] 1286404003562 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1286404003563 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1286404003564 substrate binding site [chemical binding]; other site 1286404003565 active site 1286404003566 catalytic residues [active] 1286404003567 heterodimer interface [polypeptide binding]; other site 1286404003568 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 1286404003569 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1286404003570 L-lactate permease; Region: Lactate_perm; cl00701 1286404003571 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1286404003572 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1286404003573 Double zinc ribbon; Region: DZR; pfam12773 1286404003574 Predicted membrane protein [Function unknown]; Region: COG4640 1286404003575 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1286404003576 YARHG domain; Region: YARHG; pfam13308 1286404003577 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1286404003578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404003579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404003580 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286404003581 Predicted acetyltransferase [General function prediction only]; Region: COG5628 1286404003582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404003583 Coenzyme A binding pocket [chemical binding]; other site 1286404003584 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 1286404003585 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404003586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404003587 S-adenosylmethionine binding site [chemical binding]; other site 1286404003588 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1286404003589 NADPH bind site [chemical binding]; other site 1286404003590 putative FMN binding site [chemical binding]; other site 1286404003591 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1286404003592 putative FMN binding site [chemical binding]; other site 1286404003593 NADPH bind site [chemical binding]; other site 1286404003594 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1286404003595 YcaO-like family; Region: YcaO; pfam02624 1286404003596 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1286404003597 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1286404003598 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1286404003599 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1286404003600 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286404003601 E3 interaction surface; other site 1286404003602 lipoyl attachment site [posttranslational modification]; other site 1286404003603 e3 binding domain; Region: E3_binding; pfam02817 1286404003604 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286404003605 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1286404003606 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1286404003607 TPP-binding site [chemical binding]; other site 1286404003608 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1286404003609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404003610 salt bridge; other site 1286404003611 non-specific DNA binding site [nucleotide binding]; other site 1286404003612 sequence-specific DNA binding site [nucleotide binding]; other site 1286404003613 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 1286404003614 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404003615 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1286404003616 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1286404003617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404003618 S-adenosylmethionine binding site [chemical binding]; other site 1286404003619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286404003620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404003621 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1286404003622 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1286404003623 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404003624 Catalytic site [active] 1286404003625 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1286404003626 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 1286404003627 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 1286404003628 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404003629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404003630 non-specific DNA binding site [nucleotide binding]; other site 1286404003631 salt bridge; other site 1286404003632 sequence-specific DNA binding site [nucleotide binding]; other site 1286404003633 Anti-repressor SinI; Region: SinI; pfam08671 1286404003634 Anti-repressor SinI; Region: SinI; pfam08671 1286404003635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1286404003636 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1286404003637 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1286404003638 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1286404003639 NAD(P) binding site [chemical binding]; other site 1286404003640 catalytic residues [active] 1286404003641 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286404003642 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1286404003643 Walker A/P-loop; other site 1286404003644 ATP binding site [chemical binding]; other site 1286404003645 Q-loop/lid; other site 1286404003646 ABC transporter signature motif; other site 1286404003647 Walker B; other site 1286404003648 D-loop; other site 1286404003649 H-loop/switch region; other site 1286404003650 TOBE domain; Region: TOBE_2; pfam08402 1286404003651 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286404003652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003653 dimer interface [polypeptide binding]; other site 1286404003654 conserved gate region; other site 1286404003655 putative PBP binding loops; other site 1286404003656 ABC-ATPase subunit interface; other site 1286404003657 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1286404003658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003659 dimer interface [polypeptide binding]; other site 1286404003660 conserved gate region; other site 1286404003661 putative PBP binding loops; other site 1286404003662 ABC-ATPase subunit interface; other site 1286404003663 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1286404003664 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1286404003665 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1286404003666 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286404003667 active site 1286404003668 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1286404003669 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1286404003670 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1286404003671 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286404003672 active site 1286404003673 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1286404003674 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1286404003675 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1286404003676 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286404003677 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1286404003678 Cysteine-rich domain; Region: CCG; pfam02754 1286404003679 Cysteine-rich domain; Region: CCG; pfam02754 1286404003680 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404003681 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1286404003682 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1286404003683 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1286404003684 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1286404003685 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1286404003686 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1286404003687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404003688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404003689 active site 1286404003690 phosphorylation site [posttranslational modification] 1286404003691 intermolecular recognition site; other site 1286404003692 dimerization interface [polypeptide binding]; other site 1286404003693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404003694 DNA binding site [nucleotide binding] 1286404003695 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1286404003696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404003697 dimerization interface [polypeptide binding]; other site 1286404003698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404003699 dimer interface [polypeptide binding]; other site 1286404003700 phosphorylation site [posttranslational modification] 1286404003701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404003702 ATP binding site [chemical binding]; other site 1286404003703 Mg2+ binding site [ion binding]; other site 1286404003704 G-X-G motif; other site 1286404003705 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286404003706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404003707 DNA-binding site [nucleotide binding]; DNA binding site 1286404003708 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1286404003709 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1286404003710 Cysteine-rich domain; Region: CCG; pfam02754 1286404003711 Cysteine-rich domain; Region: CCG; pfam02754 1286404003712 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1286404003713 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1286404003714 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1286404003715 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1286404003716 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1286404003717 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1286404003718 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1286404003719 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1286404003720 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1286404003721 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1286404003722 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286404003723 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404003724 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1286404003725 dimer interaction site [polypeptide binding]; other site 1286404003726 substrate-binding tunnel; other site 1286404003727 active site 1286404003728 catalytic site [active] 1286404003729 substrate binding site [chemical binding]; other site 1286404003730 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 1286404003731 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 1286404003732 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404003733 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 1286404003734 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 1286404003735 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286404003736 NAD(P) binding site [chemical binding]; other site 1286404003737 homotetramer interface [polypeptide binding]; other site 1286404003738 homodimer interface [polypeptide binding]; other site 1286404003739 active site 1286404003740 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1286404003741 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1286404003742 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1286404003743 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1286404003744 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286404003745 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1286404003746 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286404003747 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 1286404003748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1286404003749 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1286404003750 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1286404003751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404003752 Walker A/P-loop; other site 1286404003753 ATP binding site [chemical binding]; other site 1286404003754 Q-loop/lid; other site 1286404003755 ABC transporter signature motif; other site 1286404003756 Walker B; other site 1286404003757 D-loop; other site 1286404003758 H-loop/switch region; other site 1286404003759 TOBE domain; Region: TOBE_2; pfam08402 1286404003760 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1286404003761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003762 dimer interface [polypeptide binding]; other site 1286404003763 conserved gate region; other site 1286404003764 putative PBP binding loops; other site 1286404003765 ABC-ATPase subunit interface; other site 1286404003766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404003767 dimer interface [polypeptide binding]; other site 1286404003768 conserved gate region; other site 1286404003769 putative PBP binding loops; other site 1286404003770 ABC-ATPase subunit interface; other site 1286404003771 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1286404003772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404003773 motif II; other site 1286404003774 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1286404003775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404003776 catalytic residue [active] 1286404003777 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1286404003778 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286404003779 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1286404003780 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286404003781 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404003782 heme-binding site [chemical binding]; other site 1286404003783 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003784 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1286404003785 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003786 Leucine-rich repeats; other site 1286404003787 Substrate binding site [chemical binding]; other site 1286404003788 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003789 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003790 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003791 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003792 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003793 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1286404003794 LRR adjacent; Region: LRR_adjacent; pfam08191 1286404003795 S-layer homology domain; Region: SLH; pfam00395 1286404003796 S-layer homology domain; Region: SLH; pfam00395 1286404003797 S-layer homology domain; Region: SLH; pfam00395 1286404003798 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1286404003799 intersubunit interface [polypeptide binding]; other site 1286404003800 active site 1286404003801 Zn2+ binding site [ion binding]; other site 1286404003802 FOG: CBS domain [General function prediction only]; Region: COG0517 1286404003803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1286404003804 putative transposase OrfB; Reviewed; Region: PHA02517 1286404003805 HTH-like domain; Region: HTH_21; pfam13276 1286404003806 Integrase core domain; Region: rve; pfam00665 1286404003807 Integrase core domain; Region: rve_2; pfam13333 1286404003808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404003809 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404003810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404003811 Transposase; Region: HTH_Tnp_1; cl17663 1286404003812 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404003813 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1286404003814 NodB motif; other site 1286404003815 putative active site [active] 1286404003816 putative catalytic site [active] 1286404003817 Zn binding site [ion binding]; other site 1286404003818 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404003819 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 1286404003820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404003821 dimer interface [polypeptide binding]; other site 1286404003822 phosphorylation site [posttranslational modification] 1286404003823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404003824 ATP binding site [chemical binding]; other site 1286404003825 Mg2+ binding site [ion binding]; other site 1286404003826 G-X-G motif; other site 1286404003827 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404003828 MarR family; Region: MarR; pfam01047 1286404003829 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1286404003830 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1286404003831 active site 1286404003832 Zn binding site [ion binding]; other site 1286404003833 DinB superfamily; Region: DinB_2; pfam12867 1286404003834 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286404003835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404003836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404003837 dimer interface [polypeptide binding]; other site 1286404003838 phosphorylation site [posttranslational modification] 1286404003839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404003840 ATP binding site [chemical binding]; other site 1286404003841 Mg2+ binding site [ion binding]; other site 1286404003842 G-X-G motif; other site 1286404003843 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1286404003844 Ligand Binding Site [chemical binding]; other site 1286404003845 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1286404003846 active site 1286404003847 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1286404003848 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1286404003849 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1286404003850 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 1286404003851 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1286404003852 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404003853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404003854 Coenzyme A binding pocket [chemical binding]; other site 1286404003855 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1286404003856 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1286404003857 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1286404003858 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1286404003859 active site 1286404003860 dimer interface [polypeptide binding]; other site 1286404003861 catalytic residues [active] 1286404003862 effector binding site; other site 1286404003863 R2 peptide binding site; other site 1286404003864 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1286404003865 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1286404003866 dimer interface [polypeptide binding]; other site 1286404003867 putative radical transfer pathway; other site 1286404003868 diiron center [ion binding]; other site 1286404003869 tyrosyl radical; other site 1286404003870 Predicted transcriptional regulators [Transcription]; Region: COG1725 1286404003871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404003872 DNA-binding site [nucleotide binding]; DNA binding site 1286404003873 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404003874 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404003875 Walker A/P-loop; other site 1286404003876 ATP binding site [chemical binding]; other site 1286404003877 Q-loop/lid; other site 1286404003878 ABC transporter signature motif; other site 1286404003879 Walker B; other site 1286404003880 D-loop; other site 1286404003881 H-loop/switch region; other site 1286404003882 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404003883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404003884 Walker A/P-loop; other site 1286404003885 ATP binding site [chemical binding]; other site 1286404003886 Q-loop/lid; other site 1286404003887 ABC transporter signature motif; other site 1286404003888 Walker B; other site 1286404003889 D-loop; other site 1286404003890 H-loop/switch region; other site 1286404003891 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1286404003892 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1286404003893 CAAX protease self-immunity; Region: Abi; pfam02517 1286404003894 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 1286404003895 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286404003896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404003897 putative DNA binding site [nucleotide binding]; other site 1286404003898 putative Zn2+ binding site [ion binding]; other site 1286404003899 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404003900 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1286404003901 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404003902 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286404003903 catalytic triad [active] 1286404003904 conserved cis-peptide bond; other site 1286404003905 SseB protein; Region: SseB; cl06279 1286404003906 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1286404003907 dimer interface [polypeptide binding]; other site 1286404003908 catalytic triad [active] 1286404003909 Nitronate monooxygenase; Region: NMO; pfam03060 1286404003910 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1286404003911 FMN binding site [chemical binding]; other site 1286404003912 substrate binding site [chemical binding]; other site 1286404003913 putative catalytic residue [active] 1286404003914 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1286404003915 DltD N-terminal region; Region: DltD_N; pfam04915 1286404003916 DltD central region; Region: DltD_M; pfam04918 1286404003917 DltD C-terminal region; Region: DltD_C; pfam04914 1286404003918 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1286404003919 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1286404003920 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1286404003921 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1286404003922 acyl-activating enzyme (AAE) consensus motif; other site 1286404003923 AMP binding site [chemical binding]; other site 1286404003924 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1286404003925 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286404003926 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1286404003927 metal binding site [ion binding]; metal-binding site 1286404003928 dimer interface [polypeptide binding]; other site 1286404003929 flavodoxin; Provisional; Region: PRK06756 1286404003930 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1286404003931 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404003932 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404003933 active site 1286404003934 substrate binding site [chemical binding]; other site 1286404003935 ATP binding site [chemical binding]; other site 1286404003936 multidrug efflux protein; Reviewed; Region: PRK01766 1286404003937 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1286404003938 cation binding site [ion binding]; other site 1286404003939 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1286404003940 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286404003941 Regulatory protein YrvL; Region: YrvL; pfam14184 1286404003942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404003943 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286404003944 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286404003945 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1286404003946 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1286404003947 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1286404003948 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1286404003949 hypothetical protein; Provisional; Region: PRK03094 1286404003950 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 1286404003951 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286404003952 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1286404003953 homodimer interface [polypeptide binding]; other site 1286404003954 substrate-cofactor binding pocket; other site 1286404003955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404003956 catalytic residue [active] 1286404003957 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1286404003958 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286404003959 PYR/PP interface [polypeptide binding]; other site 1286404003960 dimer interface [polypeptide binding]; other site 1286404003961 TPP binding site [chemical binding]; other site 1286404003962 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286404003963 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1286404003964 TPP-binding site [chemical binding]; other site 1286404003965 dimer interface [polypeptide binding]; other site 1286404003966 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1286404003967 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1286404003968 putative valine binding site [chemical binding]; other site 1286404003969 dimer interface [polypeptide binding]; other site 1286404003970 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1286404003971 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1286404003972 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1286404003973 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1286404003974 2-isopropylmalate synthase; Validated; Region: PRK00915 1286404003975 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1286404003976 active site 1286404003977 catalytic residues [active] 1286404003978 metal binding site [ion binding]; metal-binding site 1286404003979 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1286404003980 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1286404003981 tartrate dehydrogenase; Region: TTC; TIGR02089 1286404003982 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1286404003983 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1286404003984 substrate binding site [chemical binding]; other site 1286404003985 ligand binding site [chemical binding]; other site 1286404003986 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1286404003987 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1286404003988 substrate binding site [chemical binding]; other site 1286404003989 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1286404003990 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1286404003991 dimer interface [polypeptide binding]; other site 1286404003992 motif 1; other site 1286404003993 active site 1286404003994 motif 2; other site 1286404003995 motif 3; other site 1286404003996 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1286404003997 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1286404003998 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1286404003999 histidinol dehydrogenase; Region: hisD; TIGR00069 1286404004000 NAD binding site [chemical binding]; other site 1286404004001 dimerization interface [polypeptide binding]; other site 1286404004002 product binding site; other site 1286404004003 substrate binding site [chemical binding]; other site 1286404004004 zinc binding site [ion binding]; other site 1286404004005 catalytic residues [active] 1286404004006 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1286404004007 putative active site pocket [active] 1286404004008 4-fold oligomerization interface [polypeptide binding]; other site 1286404004009 metal binding residues [ion binding]; metal-binding site 1286404004010 3-fold/trimer interface [polypeptide binding]; other site 1286404004011 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1286404004012 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1286404004013 putative active site [active] 1286404004014 oxyanion strand; other site 1286404004015 catalytic triad [active] 1286404004016 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1286404004017 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1286404004018 catalytic residues [active] 1286404004019 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1286404004020 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1286404004021 substrate binding site [chemical binding]; other site 1286404004022 glutamase interaction surface [polypeptide binding]; other site 1286404004023 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1286404004024 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1286404004025 metal binding site [ion binding]; metal-binding site 1286404004026 histidinol-phosphatase; Validated; Region: PRK06740 1286404004027 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1286404004028 dimer interface [polypeptide binding]; other site 1286404004029 active site 1286404004030 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1286404004031 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286404004032 putative ligand binding site [chemical binding]; other site 1286404004033 putative NAD binding site [chemical binding]; other site 1286404004034 catalytic site [active] 1286404004035 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1286404004036 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1286404004037 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286404004038 Sulfatase; Region: Sulfatase; pfam00884 1286404004039 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1286404004040 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1286404004041 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1286404004042 active site 1286404004043 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286404004044 substrate binding site [chemical binding]; other site 1286404004045 catalytic residues [active] 1286404004046 dimer interface [polypeptide binding]; other site 1286404004047 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 1286404004048 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1286404004049 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286404004050 Active Sites [active] 1286404004051 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1286404004052 ATP-sulfurylase; Region: ATPS; cd00517 1286404004053 active site 1286404004054 HXXH motif; other site 1286404004055 flexible loop; other site 1286404004056 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1286404004057 AAA domain; Region: AAA_18; pfam13238 1286404004058 ligand-binding site [chemical binding]; other site 1286404004059 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1286404004060 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286404004061 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286404004062 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 1286404004063 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1286404004064 diphthine synthase; Region: dph5; TIGR00522 1286404004065 active site 1286404004066 SAM binding site [chemical binding]; other site 1286404004067 homodimer interface [polypeptide binding]; other site 1286404004068 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1286404004069 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1286404004070 putative active site [active] 1286404004071 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1286404004072 putative active site [active] 1286404004073 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1286404004074 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1286404004075 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1286404004076 Na2 binding site [ion binding]; other site 1286404004077 putative substrate binding site 1 [chemical binding]; other site 1286404004078 Na binding site 1 [ion binding]; other site 1286404004079 putative substrate binding site 2 [chemical binding]; other site 1286404004080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1286404004081 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404004082 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404004083 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286404004084 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1286404004085 Protein of unknown function (DUF402); Region: DUF402; cl00979 1286404004086 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1286404004087 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286404004088 Vpu protein; Region: Vpu; pfam00558 1286404004089 PspA/IM30 family; Region: PspA_IM30; pfam04012 1286404004090 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1286404004091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404004092 Histidine kinase; Region: HisKA_3; pfam07730 1286404004093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404004094 ATP binding site [chemical binding]; other site 1286404004095 Mg2+ binding site [ion binding]; other site 1286404004096 G-X-G motif; other site 1286404004097 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404004098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404004099 active site 1286404004100 phosphorylation site [posttranslational modification] 1286404004101 intermolecular recognition site; other site 1286404004102 dimerization interface [polypeptide binding]; other site 1286404004103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404004104 DNA binding residues [nucleotide binding] 1286404004105 dimerization interface [polypeptide binding]; other site 1286404004106 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 1286404004107 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1286404004108 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404004109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404004110 S-adenosylmethionine binding site [chemical binding]; other site 1286404004111 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1286404004112 Peptidase family M50; Region: Peptidase_M50; pfam02163 1286404004113 active site 1286404004114 putative substrate binding region [chemical binding]; other site 1286404004115 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1286404004116 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1286404004117 heme-binding site [chemical binding]; other site 1286404004118 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1286404004119 FAD binding pocket [chemical binding]; other site 1286404004120 FAD binding motif [chemical binding]; other site 1286404004121 phosphate binding motif [ion binding]; other site 1286404004122 beta-alpha-beta structure motif; other site 1286404004123 NAD binding pocket [chemical binding]; other site 1286404004124 Heme binding pocket [chemical binding]; other site 1286404004125 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286404004126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286404004127 ligand binding site [chemical binding]; other site 1286404004128 flexible hinge region; other site 1286404004129 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1286404004130 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404004131 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1286404004132 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1286404004133 Transglycosylase; Region: Transgly; pfam00912 1286404004134 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1286404004135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404004136 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1286404004137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1286404004138 putative active site [active] 1286404004139 heme pocket [chemical binding]; other site 1286404004140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404004141 dimer interface [polypeptide binding]; other site 1286404004142 phosphorylation site [posttranslational modification] 1286404004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404004144 ATP binding site [chemical binding]; other site 1286404004145 Mg2+ binding site [ion binding]; other site 1286404004146 G-X-G motif; other site 1286404004147 Protein of unknown function DUF72; Region: DUF72; pfam01904 1286404004148 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 1286404004149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404004150 active site 1286404004151 DNA binding site [nucleotide binding] 1286404004152 Int/Topo IB signature motif; other site 1286404004153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404004154 dimerization interface [polypeptide binding]; other site 1286404004155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404004156 dimer interface [polypeptide binding]; other site 1286404004157 phosphorylation site [posttranslational modification] 1286404004158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404004159 ATP binding site [chemical binding]; other site 1286404004160 Mg2+ binding site [ion binding]; other site 1286404004161 G-X-G motif; other site 1286404004162 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1286404004163 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1286404004164 Predicted integral membrane protein [Function unknown]; Region: COG0392 1286404004165 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1286404004166 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1286404004167 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1286404004168 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1286404004169 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1286404004170 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1286404004171 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286404004172 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404004173 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1286404004174 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1286404004175 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1286404004176 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1286404004177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404004178 RNA binding surface [nucleotide binding]; other site 1286404004179 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1286404004180 active site 1286404004181 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1286404004182 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286404004183 catalytic residues [active] 1286404004184 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1286404004185 ResB-like family; Region: ResB; pfam05140 1286404004186 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1286404004187 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1286404004188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404004189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404004190 active site 1286404004191 phosphorylation site [posttranslational modification] 1286404004192 intermolecular recognition site; other site 1286404004193 dimerization interface [polypeptide binding]; other site 1286404004194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404004195 DNA binding site [nucleotide binding] 1286404004196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1286404004197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404004198 dimerization interface [polypeptide binding]; other site 1286404004199 PAS domain; Region: PAS; smart00091 1286404004200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404004201 dimer interface [polypeptide binding]; other site 1286404004202 phosphorylation site [posttranslational modification] 1286404004203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404004204 ATP binding site [chemical binding]; other site 1286404004205 Mg2+ binding site [ion binding]; other site 1286404004206 G-X-G motif; other site 1286404004207 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1286404004208 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404004209 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404004210 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1286404004211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404004212 Predicted membrane protein [Function unknown]; Region: COG3601 1286404004213 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1286404004214 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1286404004215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1286404004216 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286404004217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404004218 ATP binding site [chemical binding]; other site 1286404004219 putative Mg++ binding site [ion binding]; other site 1286404004220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404004221 nucleotide binding region [chemical binding]; other site 1286404004222 ATP-binding site [chemical binding]; other site 1286404004223 CAAX protease self-immunity; Region: Abi; pfam02517 1286404004224 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404004225 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1286404004226 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404004227 putative active site [active] 1286404004228 putative metal binding site [ion binding]; other site 1286404004229 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404004230 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1286404004231 DNA binding residues [nucleotide binding] 1286404004232 B12 binding domain; Region: B12-binding_2; pfam02607 1286404004233 adaptor protein; Provisional; Region: PRK02899 1286404004234 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1286404004235 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1286404004236 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1286404004237 NAD(P) binding site [chemical binding]; other site 1286404004238 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 1286404004239 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404004240 amidase catalytic site [active] 1286404004241 Zn binding residues [ion binding]; other site 1286404004242 substrate binding site [chemical binding]; other site 1286404004243 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1286404004244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1286404004245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404004246 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1286404004247 active site 1286404004248 homodimer interface [polypeptide binding]; other site 1286404004249 homotetramer interface [polypeptide binding]; other site 1286404004250 cytidylate kinase; Provisional; Region: cmk; PRK00023 1286404004251 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1286404004252 CMP-binding site; other site 1286404004253 The sites determining sugar specificity; other site 1286404004254 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1286404004255 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1286404004256 RNA binding site [nucleotide binding]; other site 1286404004257 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1286404004258 RNA binding site [nucleotide binding]; other site 1286404004259 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1286404004260 RNA binding site [nucleotide binding]; other site 1286404004261 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1286404004262 RNA binding site [nucleotide binding]; other site 1286404004263 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1286404004264 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1286404004265 homotetramer interface [polypeptide binding]; other site 1286404004266 FMN binding site [chemical binding]; other site 1286404004267 homodimer contacts [polypeptide binding]; other site 1286404004268 putative active site [active] 1286404004269 putative substrate binding site [chemical binding]; other site 1286404004270 YpzI-like protein; Region: YpzI; pfam14140 1286404004271 YIEGIA protein; Region: YIEGIA; pfam14045 1286404004272 GTP-binding protein Der; Reviewed; Region: PRK00093 1286404004273 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1286404004274 G1 box; other site 1286404004275 GTP/Mg2+ binding site [chemical binding]; other site 1286404004276 Switch I region; other site 1286404004277 G2 box; other site 1286404004278 Switch II region; other site 1286404004279 G3 box; other site 1286404004280 G4 box; other site 1286404004281 G5 box; other site 1286404004282 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1286404004283 G1 box; other site 1286404004284 GTP/Mg2+ binding site [chemical binding]; other site 1286404004285 Switch I region; other site 1286404004286 G2 box; other site 1286404004287 G3 box; other site 1286404004288 Switch II region; other site 1286404004289 G4 box; other site 1286404004290 G5 box; other site 1286404004291 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1286404004292 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286404004293 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1286404004294 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1286404004295 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1286404004296 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1286404004297 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1286404004298 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286404004299 IHF dimer interface [polypeptide binding]; other site 1286404004300 IHF - DNA interface [nucleotide binding]; other site 1286404004301 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1286404004302 homodecamer interface [polypeptide binding]; other site 1286404004303 GTP cyclohydrolase I; Provisional; Region: PLN03044 1286404004304 active site 1286404004305 putative catalytic site residues [active] 1286404004306 zinc binding site [ion binding]; other site 1286404004307 GTP-CH-I/GFRP interaction surface; other site 1286404004308 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1286404004309 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1286404004310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404004311 S-adenosylmethionine binding site [chemical binding]; other site 1286404004312 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1286404004313 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1286404004314 substrate binding pocket [chemical binding]; other site 1286404004315 chain length determination region; other site 1286404004316 substrate-Mg2+ binding site; other site 1286404004317 catalytic residues [active] 1286404004318 aspartate-rich region 1; other site 1286404004319 active site lid residues [active] 1286404004320 aspartate-rich region 2; other site 1286404004321 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1286404004322 active site 1286404004323 multimer interface [polypeptide binding]; other site 1286404004324 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1286404004325 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1286404004326 Tetramer interface [polypeptide binding]; other site 1286404004327 active site 1286404004328 FMN-binding site [chemical binding]; other site 1286404004329 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1286404004330 active site 1286404004331 dimer interface [polypeptide binding]; other site 1286404004332 metal binding site [ion binding]; metal-binding site 1286404004333 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1286404004334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404004335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404004336 homodimer interface [polypeptide binding]; other site 1286404004337 catalytic residue [active] 1286404004338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404004339 binding surface 1286404004340 TPR motif; other site 1286404004341 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1286404004342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404004343 binding surface 1286404004344 TPR motif; other site 1286404004345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404004346 binding surface 1286404004347 TPR motif; other site 1286404004348 UPF0302 domain; Region: UPF0302; pfam08864 1286404004349 IDEAL domain; Region: IDEAL; pfam08858 1286404004350 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1286404004351 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1286404004352 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1286404004353 iron-sulfur cluster [ion binding]; other site 1286404004354 [2Fe-2S] cluster binding site [ion binding]; other site 1286404004355 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1286404004356 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1286404004357 interchain domain interface [polypeptide binding]; other site 1286404004358 intrachain domain interface; other site 1286404004359 heme bH binding site [chemical binding]; other site 1286404004360 Qi binding site; other site 1286404004361 heme bL binding site [chemical binding]; other site 1286404004362 Qo binding site; other site 1286404004363 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1286404004364 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1286404004365 interchain domain interface [polypeptide binding]; other site 1286404004366 intrachain domain interface; other site 1286404004367 Qi binding site; other site 1286404004368 Qo binding site; other site 1286404004369 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286404004370 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286404004371 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 1286404004372 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1286404004373 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1286404004374 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1286404004375 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1286404004376 active site 1286404004377 Fe-S cluster binding site [ion binding]; other site 1286404004378 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404004379 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404004380 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404004381 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404004382 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1286404004383 homodimer interface [polypeptide binding]; other site 1286404004384 metal binding site [ion binding]; metal-binding site 1286404004385 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1286404004386 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1286404004387 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1286404004388 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1286404004389 active site 1286404004390 dimer interfaces [polypeptide binding]; other site 1286404004391 catalytic residues [active] 1286404004392 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1286404004393 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1286404004394 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1286404004395 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1286404004396 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1286404004397 active site 1286404004398 NTP binding site [chemical binding]; other site 1286404004399 metal binding triad [ion binding]; metal-binding site 1286404004400 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1286404004401 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1286404004402 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1286404004403 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1286404004404 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1286404004405 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1286404004406 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1286404004407 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1286404004408 oligomerization interface [polypeptide binding]; other site 1286404004409 active site 1286404004410 metal binding site [ion binding]; metal-binding site 1286404004411 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1286404004412 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1286404004413 active site 1286404004414 ATP-binding site [chemical binding]; other site 1286404004415 pantoate-binding site; other site 1286404004416 HXXH motif; other site 1286404004417 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1286404004418 tetramerization interface [polypeptide binding]; other site 1286404004419 active site 1286404004420 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1286404004421 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1286404004422 active site 1286404004423 catalytic site [active] 1286404004424 substrate binding site [chemical binding]; other site 1286404004425 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1286404004426 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1286404004427 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1286404004428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1286404004429 aspartate aminotransferase; Provisional; Region: PRK05764 1286404004430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404004431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404004432 homodimer interface [polypeptide binding]; other site 1286404004433 catalytic residue [active] 1286404004434 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1286404004435 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1286404004436 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404004437 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1286404004438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286404004439 minor groove reading motif; other site 1286404004440 helix-hairpin-helix signature motif; other site 1286404004441 substrate binding pocket [chemical binding]; other site 1286404004442 active site 1286404004443 Transglycosylase; Region: Transgly; pfam00912 1286404004444 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1286404004445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404004446 Fibronectin type III domain; Region: fn3; pfam00041 1286404004447 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1286404004448 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1286404004449 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1286404004450 YppF-like protein; Region: YppF; pfam14178 1286404004451 YppG-like protein; Region: YppG; pfam14179 1286404004452 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1286404004453 hypothetical protein; Provisional; Region: PRK13660 1286404004454 cell division protein GpsB; Provisional; Region: PRK14127 1286404004455 DivIVA domain; Region: DivI1A_domain; TIGR03544 1286404004456 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1286404004457 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1286404004458 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1286404004459 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 1286404004460 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1286404004461 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1286404004462 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1286404004463 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1286404004464 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1286404004465 active site 1286404004466 Zn binding site [ion binding]; other site 1286404004467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404004468 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404004469 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286404004470 active site 1286404004471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404004472 active site 1286404004473 xanthine permease; Region: pbuX; TIGR03173 1286404004474 Predicted membrane protein [Function unknown]; Region: COG2311 1286404004475 Protein of unknown function (DUF418); Region: DUF418; cl12135 1286404004476 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1286404004477 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1286404004478 Dynamin family; Region: Dynamin_N; pfam00350 1286404004479 G1 box; other site 1286404004480 GTP/Mg2+ binding site [chemical binding]; other site 1286404004481 G2 box; other site 1286404004482 Switch I region; other site 1286404004483 G3 box; other site 1286404004484 Switch II region; other site 1286404004485 G4 box; other site 1286404004486 G5 box; other site 1286404004487 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1286404004488 Dynamin family; Region: Dynamin_N; pfam00350 1286404004489 G1 box; other site 1286404004490 GTP/Mg2+ binding site [chemical binding]; other site 1286404004491 G2 box; other site 1286404004492 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1286404004493 G3 box; other site 1286404004494 Switch II region; other site 1286404004495 GTP/Mg2+ binding site [chemical binding]; other site 1286404004496 G4 box; other site 1286404004497 G5 box; other site 1286404004498 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 1286404004499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404004500 Coenzyme A binding pocket [chemical binding]; other site 1286404004501 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1286404004502 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1286404004503 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1286404004504 active site residue [active] 1286404004505 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1286404004506 active site residue [active] 1286404004507 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1286404004508 Predicted membrane protein [Function unknown]; Region: COG3766 1286404004509 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1286404004510 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1286404004511 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404004512 5'-3' exonuclease; Region: 53EXOc; smart00475 1286404004513 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1286404004514 active site 1286404004515 metal binding site 1 [ion binding]; metal-binding site 1286404004516 putative 5' ssDNA interaction site; other site 1286404004517 metal binding site 3; metal-binding site 1286404004518 metal binding site 2 [ion binding]; metal-binding site 1286404004519 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1286404004520 putative DNA binding site [nucleotide binding]; other site 1286404004521 putative metal binding site [ion binding]; other site 1286404004522 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1286404004523 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286404004524 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1286404004525 Chain length determinant protein; Region: Wzz; cl15801 1286404004526 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1286404004527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286404004528 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1286404004529 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286404004530 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1286404004531 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1286404004532 O-Antigen ligase; Region: Wzy_C; pfam04932 1286404004533 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404004534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286404004535 active site 1286404004536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404004537 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286404004538 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1286404004539 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004540 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004541 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004542 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004543 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004544 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004545 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004546 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004547 Domain of unknown function DUF11; Region: DUF11; cl17728 1286404004548 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004549 Domain of unknown function DUF11; Region: DUF11; cl17728 1286404004550 Domain of unknown function DUF11; Region: DUF11; cl17728 1286404004551 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004552 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004553 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004554 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004555 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004556 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004557 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004558 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004559 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004560 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004561 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004562 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004563 Domain of unknown function DUF11; Region: DUF11; cl17728 1286404004564 Domain of unknown function DUF11; Region: DUF11; cl17728 1286404004565 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004566 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404004567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286404004568 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286404004569 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404004570 catalytic triad [active] 1286404004571 conserved cis-peptide bond; other site 1286404004572 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404004573 EamA-like transporter family; Region: EamA; pfam00892 1286404004574 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1286404004575 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286404004576 active site 1286404004577 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404004578 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404004579 putative active site [active] 1286404004580 putative NTP binding site [chemical binding]; other site 1286404004581 putative nucleic acid binding site [nucleotide binding]; other site 1286404004582 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404004583 active site 1286404004584 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1286404004585 active site 1286404004586 catalytic residues [active] 1286404004587 QueT transporter; Region: QueT; pfam06177 1286404004588 hypothetical protein; Validated; Region: PRK07708 1286404004589 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1286404004590 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286404004591 active site 1286404004592 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1286404004593 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1286404004594 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404004595 DNA-binding site [nucleotide binding]; DNA binding site 1286404004596 RNA-binding motif; other site 1286404004597 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1286404004598 LysE type translocator; Region: LysE; pfam01810 1286404004599 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1286404004600 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1286404004601 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1286404004602 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1286404004603 Na binding site [ion binding]; other site 1286404004604 aminotransferase; Validated; Region: PRK07678 1286404004605 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404004606 inhibitor-cofactor binding pocket; inhibition site 1286404004607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404004608 catalytic residue [active] 1286404004609 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1286404004610 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404004611 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404004612 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404004613 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1286404004614 DNA binding residues [nucleotide binding] 1286404004615 drug binding residues [chemical binding]; other site 1286404004616 dimer interface [polypeptide binding]; other site 1286404004617 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1286404004618 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1286404004619 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1286404004620 Predicted membrane protein [Function unknown]; Region: COG2323 1286404004621 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286404004622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286404004623 putative active site [active] 1286404004624 Tic20-like protein; Region: Tic20; pfam09685 1286404004625 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1286404004626 dimer interface [polypeptide binding]; other site 1286404004627 FMN binding site [chemical binding]; other site 1286404004628 NADPH bind site [chemical binding]; other site 1286404004629 RNA polymerase factor sigma-70; Validated; Region: PRK06811 1286404004630 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404004631 DNA binding residues [nucleotide binding] 1286404004632 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404004633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404004634 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404004635 putative substrate translocation pore; other site 1286404004636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404004637 dimerization interface [polypeptide binding]; other site 1286404004638 putative DNA binding site [nucleotide binding]; other site 1286404004639 putative Zn2+ binding site [ion binding]; other site 1286404004640 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404004641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404004642 putative substrate translocation pore; other site 1286404004643 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404004644 active site 1286404004645 metal binding site [ion binding]; metal-binding site 1286404004646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404004647 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404004648 bacterial Hfq-like; Region: Hfq; cd01716 1286404004649 hexamer interface [polypeptide binding]; other site 1286404004650 Sm1 motif; other site 1286404004651 RNA binding site [nucleotide binding]; other site 1286404004652 Sm2 motif; other site 1286404004653 HD domain; Region: HD_3; pfam13023 1286404004654 flagellar motor protein MotP; Reviewed; Region: PRK06743 1286404004655 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1286404004656 flagellar motor protein MotS; Reviewed; Region: PRK06742 1286404004657 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286404004658 ligand binding site [chemical binding]; other site 1286404004659 Response regulator receiver domain; Region: Response_reg; pfam00072 1286404004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404004661 active site 1286404004662 phosphorylation site [posttranslational modification] 1286404004663 intermolecular recognition site; other site 1286404004664 dimerization interface [polypeptide binding]; other site 1286404004665 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1286404004666 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1286404004667 putative binding surface; other site 1286404004668 active site 1286404004669 P2 response regulator binding domain; Region: P2; pfam07194 1286404004670 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1286404004671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404004672 ATP binding site [chemical binding]; other site 1286404004673 Mg2+ binding site [ion binding]; other site 1286404004674 G-X-G motif; other site 1286404004675 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1286404004676 flagellar motor switch protein; Reviewed; Region: PRK06782 1286404004677 CheC-like family; Region: CheC; pfam04509 1286404004678 CheC-like family; Region: CheC; pfam04509 1286404004679 CheC-like family; Region: CheC; pfam04509 1286404004680 CheC-like family; Region: CheC; pfam04509 1286404004681 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1286404004682 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1286404004683 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1286404004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404004685 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1286404004686 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 1286404004687 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 1286404004688 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286404004689 flagellar capping protein; Validated; Region: fliD; PRK06798 1286404004690 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1286404004691 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1286404004692 Flagellar protein FliS; Region: FliS; cl00654 1286404004693 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 1286404004694 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1286404004695 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1286404004696 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1286404004697 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 1286404004698 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1286404004699 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1286404004700 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1286404004701 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1286404004702 FliG C-terminal domain; Region: FliG_C; pfam01706 1286404004703 flagellar assembly protein H; Validated; Region: fliH; PRK06800 1286404004704 Flagellar assembly protein FliH; Region: FliH; pfam02108 1286404004705 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 1286404004706 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404004707 Walker A motif; other site 1286404004708 ATP binding site [chemical binding]; other site 1286404004709 Walker B motif; other site 1286404004710 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1286404004711 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 1286404004712 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1286404004713 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1286404004714 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1286404004715 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1286404004716 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1286404004717 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 1286404004718 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1286404004719 Response regulator receiver domain; Region: Response_reg; pfam00072 1286404004720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404004721 active site 1286404004722 phosphorylation site [posttranslational modification] 1286404004723 intermolecular recognition site; other site 1286404004724 dimerization interface [polypeptide binding]; other site 1286404004725 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 1286404004726 flagellin; Provisional; Region: PRK12807 1286404004727 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286404004728 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286404004729 flagellin; Reviewed; Region: PRK08869 1286404004730 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1286404004731 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1286404004732 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1286404004733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286404004734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286404004735 catalytic residue [active] 1286404004736 flagellar motor switch protein; Validated; Region: PRK06789 1286404004737 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1286404004738 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1286404004739 flagellar motor switch protein; Validated; Region: PRK06788 1286404004740 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1286404004741 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1286404004742 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1286404004743 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1286404004744 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1286404004745 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1286404004746 FHIPEP family; Region: FHIPEP; pfam00771 1286404004747 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 1286404004748 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286404004749 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 1286404004750 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1286404004751 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1286404004752 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1286404004753 active site 1286404004754 non-prolyl cis peptide bond; other site 1286404004755 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1286404004756 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1286404004757 Predicted transcriptional regulators [Transcription]; Region: COG1378 1286404004758 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1286404004759 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1286404004760 C-terminal domain interface [polypeptide binding]; other site 1286404004761 sugar binding site [chemical binding]; other site 1286404004762 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1286404004763 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1286404004764 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 1286404004765 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1286404004766 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1286404004767 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1286404004768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286404004769 DXD motif; other site 1286404004770 PilZ domain; Region: PilZ; pfam07238 1286404004771 PilZ domain; Region: PilZ; pfam07238 1286404004772 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 1286404004773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404004774 non-specific DNA binding site [nucleotide binding]; other site 1286404004775 salt bridge; other site 1286404004776 sequence-specific DNA binding site [nucleotide binding]; other site 1286404004777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404004778 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404004779 putative substrate translocation pore; other site 1286404004780 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1286404004781 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1286404004782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404004783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404004784 dimerization interface [polypeptide binding]; other site 1286404004785 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1286404004786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404004787 Walker A/P-loop; other site 1286404004788 ATP binding site [chemical binding]; other site 1286404004789 Q-loop/lid; other site 1286404004790 ABC transporter signature motif; other site 1286404004791 Walker B; other site 1286404004792 D-loop; other site 1286404004793 H-loop/switch region; other site 1286404004794 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1286404004795 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1286404004796 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1286404004797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404004798 dimer interface [polypeptide binding]; other site 1286404004799 conserved gate region; other site 1286404004800 putative PBP binding loops; other site 1286404004801 ABC-ATPase subunit interface; other site 1286404004802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404004803 dimer interface [polypeptide binding]; other site 1286404004804 conserved gate region; other site 1286404004805 putative PBP binding loops; other site 1286404004806 ABC-ATPase subunit interface; other site 1286404004807 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1286404004808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1286404004809 Beta-Casp domain; Region: Beta-Casp; smart01027 1286404004810 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1286404004811 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404004812 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404004813 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1286404004814 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286404004815 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1286404004816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404004817 catalytic core [active] 1286404004818 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1286404004819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404004820 hypothetical protein; Provisional; Region: PRK09272 1286404004821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404004822 dimerization interface [polypeptide binding]; other site 1286404004823 putative Zn2+ binding site [ion binding]; other site 1286404004824 putative DNA binding site [nucleotide binding]; other site 1286404004825 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1286404004826 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286404004827 active site 1286404004828 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1286404004829 dimer interface [polypeptide binding]; other site 1286404004830 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286404004831 Ligand Binding Site [chemical binding]; other site 1286404004832 Molecular Tunnel; other site 1286404004833 RNA polymerase factor sigma-70; Validated; Region: PRK06811 1286404004834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404004835 DNA binding residues [nucleotide binding] 1286404004836 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1286404004837 VPS10 domain; Region: VPS10; smart00602 1286404004838 VPS10 domain; Region: VPS10; smart00602 1286404004839 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1286404004840 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286404004841 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1286404004842 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286404004843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404004844 DNA-binding site [nucleotide binding]; DNA binding site 1286404004845 FCD domain; Region: FCD; pfam07729 1286404004846 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404004847 EamA-like transporter family; Region: EamA; pfam00892 1286404004848 EamA-like transporter family; Region: EamA; pfam00892 1286404004849 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286404004850 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1286404004851 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1286404004852 Predicted permeases [General function prediction only]; Region: COG0701 1286404004853 TIGR03943 family protein; Region: TIGR03943 1286404004854 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1286404004855 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1286404004856 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1286404004857 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404004858 DNA binding residues [nucleotide binding] 1286404004859 putative dimer interface [polypeptide binding]; other site 1286404004860 short chain dehydrogenase; Provisional; Region: PRK06123 1286404004861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404004862 NAD(P) binding site [chemical binding]; other site 1286404004863 active site 1286404004864 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1286404004865 Class II fumarases; Region: Fumarase_classII; cd01362 1286404004866 active site 1286404004867 tetramer interface [polypeptide binding]; other site 1286404004868 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1286404004869 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1286404004870 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1286404004871 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1286404004872 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1286404004873 active site pocket [active] 1286404004874 oxyanion hole [active] 1286404004875 catalytic triad [active] 1286404004876 active site nucleophile [active] 1286404004877 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 1286404004878 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1286404004879 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1286404004880 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1286404004881 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1286404004882 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1286404004883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286404004884 catalytic residues [active] 1286404004885 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1286404004886 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404004887 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1286404004888 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286404004889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404004890 non-specific DNA binding site [nucleotide binding]; other site 1286404004891 salt bridge; other site 1286404004892 sequence-specific DNA binding site [nucleotide binding]; other site 1286404004893 Cupin domain; Region: Cupin_2; pfam07883 1286404004894 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1286404004895 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1286404004896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404004897 catalytic residue [active] 1286404004898 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1286404004899 Pleckstrin homology-like domain; Region: PH-like; cl17171 1286404004900 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 1286404004901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404004902 DNA binding residues [nucleotide binding] 1286404004903 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404004904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404004905 active site 1286404004906 phosphorylation site [posttranslational modification] 1286404004907 intermolecular recognition site; other site 1286404004908 dimerization interface [polypeptide binding]; other site 1286404004909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404004910 DNA binding residues [nucleotide binding] 1286404004911 dimerization interface [polypeptide binding]; other site 1286404004912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404004913 Histidine kinase; Region: HisKA_3; pfam07730 1286404004914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404004915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404004916 Walker A/P-loop; other site 1286404004917 ATP binding site [chemical binding]; other site 1286404004918 Q-loop/lid; other site 1286404004919 ABC transporter signature motif; other site 1286404004920 Walker B; other site 1286404004921 D-loop; other site 1286404004922 H-loop/switch region; other site 1286404004923 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1286404004924 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286404004925 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1286404004926 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286404004927 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1286404004928 putative active site [active] 1286404004929 catalytic site [active] 1286404004930 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1286404004931 PLD-like domain; Region: PLDc_2; pfam13091 1286404004932 putative active site [active] 1286404004933 catalytic site [active] 1286404004934 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1286404004935 putative nucleotide binding site [chemical binding]; other site 1286404004936 uridine monophosphate binding site [chemical binding]; other site 1286404004937 homohexameric interface [polypeptide binding]; other site 1286404004938 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286404004939 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1286404004940 aspartate ammonia-lyase; Provisional; Region: PRK14515 1286404004941 Aspartase; Region: Aspartase; cd01357 1286404004942 active sites [active] 1286404004943 tetramer interface [polypeptide binding]; other site 1286404004944 malate dehydrogenase; Provisional; Region: PRK13529 1286404004945 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286404004946 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1286404004947 NAD(P) binding site [chemical binding]; other site 1286404004948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404004949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404004950 ATP binding site [chemical binding]; other site 1286404004951 Mg2+ binding site [ion binding]; other site 1286404004952 G-X-G motif; other site 1286404004953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404004954 Response regulator receiver domain; Region: Response_reg; pfam00072 1286404004955 active site 1286404004956 phosphorylation site [posttranslational modification] 1286404004957 intermolecular recognition site; other site 1286404004958 dimerization interface [polypeptide binding]; other site 1286404004959 YcbB domain; Region: YcbB; pfam08664 1286404004960 SWIM zinc finger; Region: SWIM; pfam04434 1286404004961 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1286404004962 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1286404004963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404004964 ATP binding site [chemical binding]; other site 1286404004965 putative Mg++ binding site [ion binding]; other site 1286404004966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404004967 nucleotide binding region [chemical binding]; other site 1286404004968 ATP-binding site [chemical binding]; other site 1286404004969 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1286404004970 dimer interface [polypeptide binding]; other site 1286404004971 active site 1286404004972 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404004973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404004974 non-specific DNA binding site [nucleotide binding]; other site 1286404004975 salt bridge; other site 1286404004976 sequence-specific DNA binding site [nucleotide binding]; other site 1286404004977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1286404004978 putative dimer interface [polypeptide binding]; other site 1286404004979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404004980 aspartate kinase; Reviewed; Region: PRK06635 1286404004981 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1286404004982 putative nucleotide binding site [chemical binding]; other site 1286404004983 putative catalytic residues [active] 1286404004984 putative Mg ion binding site [ion binding]; other site 1286404004985 putative aspartate binding site [chemical binding]; other site 1286404004986 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1286404004987 putative allosteric regulatory site; other site 1286404004988 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1286404004989 putative allosteric regulatory residue; other site 1286404004990 DoxX-like family; Region: DoxX_3; pfam13781 1286404004991 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1286404004992 YndJ-like protein; Region: YndJ; pfam14158 1286404004993 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1286404004994 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404004995 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404004996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404004997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404004998 putative substrate translocation pore; other site 1286404004999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005000 putative substrate translocation pore; other site 1286404005001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404005003 putative substrate translocation pore; other site 1286404005004 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1286404005005 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1286404005006 dimer interface [polypeptide binding]; other site 1286404005007 active site 1286404005008 CoA binding pocket [chemical binding]; other site 1286404005009 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1286404005010 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1286404005011 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1286404005012 HflX GTPase family; Region: HflX; cd01878 1286404005013 G1 box; other site 1286404005014 GTP/Mg2+ binding site [chemical binding]; other site 1286404005015 Switch I region; other site 1286404005016 G2 box; other site 1286404005017 G3 box; other site 1286404005018 Switch II region; other site 1286404005019 G4 box; other site 1286404005020 G5 box; other site 1286404005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404005023 putative substrate translocation pore; other site 1286404005024 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286404005025 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286404005026 dimer interface [polypeptide binding]; other site 1286404005027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005028 catalytic residue [active] 1286404005029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404005030 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1286404005031 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1286404005032 Na2 binding site [ion binding]; other site 1286404005033 putative substrate binding site 1 [chemical binding]; other site 1286404005034 Na binding site 1 [ion binding]; other site 1286404005035 putative substrate binding site 2 [chemical binding]; other site 1286404005036 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404005037 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 1286404005038 NodB motif; other site 1286404005039 putative active site [active] 1286404005040 putative catalytic site [active] 1286404005041 putative Zn binding site [ion binding]; other site 1286404005042 Mor transcription activator family; Region: Mor; cl02360 1286404005043 Predicted membrane protein [Function unknown]; Region: COG2323 1286404005044 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1286404005045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1286404005046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1286404005047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1286404005048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1286404005049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1286404005050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1286404005051 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1286404005052 short chain dehydrogenase; Provisional; Region: PRK12747 1286404005053 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1286404005054 NADP binding site [chemical binding]; other site 1286404005055 homodimer interface [polypeptide binding]; other site 1286404005056 active site 1286404005057 substrate binding site [chemical binding]; other site 1286404005058 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286404005059 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1286404005060 homodimer interface [polypeptide binding]; other site 1286404005061 substrate-cofactor binding pocket; other site 1286404005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005063 catalytic residue [active] 1286404005064 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 1286404005065 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1286404005066 PYR/PP interface [polypeptide binding]; other site 1286404005067 dimer interface [polypeptide binding]; other site 1286404005068 TPP binding site [chemical binding]; other site 1286404005069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286404005070 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1286404005071 TPP-binding site [chemical binding]; other site 1286404005072 dimer interface [polypeptide binding]; other site 1286404005073 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1286404005074 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1286404005075 putative valine binding site [chemical binding]; other site 1286404005076 dimer interface [polypeptide binding]; other site 1286404005077 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1286404005078 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1286404005079 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1286404005080 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1286404005081 threonine dehydratase; Validated; Region: PRK08639 1286404005082 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286404005083 tetramer interface [polypeptide binding]; other site 1286404005084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005085 catalytic residue [active] 1286404005086 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1286404005087 putative Ile/Val binding site [chemical binding]; other site 1286404005088 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1286404005089 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1286404005090 putative active site [active] 1286404005091 putative metal binding site [ion binding]; other site 1286404005092 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1286404005093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005094 Coenzyme A binding pocket [chemical binding]; other site 1286404005095 drug efflux system protein MdtG; Provisional; Region: PRK09874 1286404005096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005097 putative substrate translocation pore; other site 1286404005098 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1286404005099 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1286404005100 putative active site [active] 1286404005101 metal binding site [ion binding]; metal-binding site 1286404005102 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1286404005103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404005104 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286404005105 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1286404005106 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1286404005107 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1286404005108 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1286404005109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404005110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005111 Coenzyme A binding pocket [chemical binding]; other site 1286404005112 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 1286404005113 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1286404005114 active site 1286404005115 putative substrate binding pocket [chemical binding]; other site 1286404005116 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404005117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404005118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404005119 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404005120 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404005121 peptide binding site [polypeptide binding]; other site 1286404005122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404005123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005124 Coenzyme A binding pocket [chemical binding]; other site 1286404005125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404005126 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404005128 active site 1286404005129 phosphorylation site [posttranslational modification] 1286404005130 intermolecular recognition site; other site 1286404005131 dimerization interface [polypeptide binding]; other site 1286404005132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404005133 DNA binding site [nucleotide binding] 1286404005134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404005135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404005136 dimerization interface [polypeptide binding]; other site 1286404005137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404005138 dimer interface [polypeptide binding]; other site 1286404005139 phosphorylation site [posttranslational modification] 1286404005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404005141 ATP binding site [chemical binding]; other site 1286404005142 Mg2+ binding site [ion binding]; other site 1286404005143 G-X-G motif; other site 1286404005144 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404005145 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404005146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404005147 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286404005148 manganese transport protein MntH; Reviewed; Region: PRK00701 1286404005149 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1286404005150 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1286404005151 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1286404005152 active site residue [active] 1286404005153 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1286404005154 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1286404005155 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1286404005156 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1286404005157 Amino acid permease; Region: AA_permease_2; pfam13520 1286404005158 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404005159 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404005160 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404005161 Peptidase M60-like family; Region: M60-like; pfam13402 1286404005162 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1286404005163 sugar binding site [chemical binding]; other site 1286404005164 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1286404005165 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1286404005166 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404005167 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404005168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404005169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404005170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005171 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404005172 Coenzyme A binding pocket [chemical binding]; other site 1286404005173 hypothetical protein; Provisional; Region: PRK12856 1286404005174 CAAX protease self-immunity; Region: Abi; pfam02517 1286404005175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404005176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404005177 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286404005178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404005179 DNA binding residues [nucleotide binding] 1286404005180 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286404005181 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1286404005182 intersubunit interface [polypeptide binding]; other site 1286404005183 active site 1286404005184 catalytic residue [active] 1286404005185 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404005186 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404005187 Nucleoside recognition; Region: Gate; pfam07670 1286404005188 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404005189 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1286404005190 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286404005191 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286404005192 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1286404005193 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1286404005194 active site 1286404005195 catalytic motif [active] 1286404005196 Zn binding site [ion binding]; other site 1286404005197 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1286404005198 hypothetical protein; Provisional; Region: PRK01631 1286404005199 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1286404005200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404005201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404005202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404005203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404005204 dimerization interface [polypeptide binding]; other site 1286404005205 Family description; Region: DsbD_2; pfam13386 1286404005206 VPS10 domain; Region: VPS10; smart00602 1286404005207 proline aminopeptidase P II; Provisional; Region: PRK10879 1286404005208 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1286404005209 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1286404005210 active site 1286404005211 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1286404005212 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1286404005213 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1286404005214 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1286404005215 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1286404005216 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1286404005217 DNA topoisomerase III; Provisional; Region: PRK07726 1286404005218 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1286404005219 active site 1286404005220 putative interdomain interaction site [polypeptide binding]; other site 1286404005221 putative metal-binding site [ion binding]; other site 1286404005222 putative nucleotide binding site [chemical binding]; other site 1286404005223 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286404005224 domain I; other site 1286404005225 DNA binding groove [nucleotide binding] 1286404005226 phosphate binding site [ion binding]; other site 1286404005227 domain II; other site 1286404005228 domain III; other site 1286404005229 nucleotide binding site [chemical binding]; other site 1286404005230 catalytic site [active] 1286404005231 domain IV; other site 1286404005232 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286404005233 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404005234 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1286404005235 Sodium Bile acid symporter family; Region: SBF; cl17470 1286404005236 azoreductase; Provisional; Region: PRK13555 1286404005237 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1286404005238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404005239 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1286404005240 dimer interface [polypeptide binding]; other site 1286404005241 substrate binding site [chemical binding]; other site 1286404005242 metal binding site [ion binding]; metal-binding site 1286404005243 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1286404005244 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1286404005245 YtkA-like; Region: YtkA; pfam13115 1286404005246 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1286404005247 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1286404005248 EamA-like transporter family; Region: EamA; pfam00892 1286404005249 EamA-like transporter family; Region: EamA; pfam00892 1286404005250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404005251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404005252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404005253 dimerization interface [polypeptide binding]; other site 1286404005254 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286404005255 Transcriptional regulator; Region: Rrf2; pfam02082 1286404005256 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1286404005257 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1286404005258 catalytic residues [active] 1286404005259 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1286404005260 dimer interface [polypeptide binding]; other site 1286404005261 FMN binding site [chemical binding]; other site 1286404005262 Amidase; Region: Amidase; cl11426 1286404005263 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404005264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404005265 non-specific DNA binding site [nucleotide binding]; other site 1286404005266 salt bridge; other site 1286404005267 sequence-specific DNA binding site [nucleotide binding]; other site 1286404005268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404005269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404005270 non-specific DNA binding site [nucleotide binding]; other site 1286404005271 salt bridge; other site 1286404005272 sequence-specific DNA binding site [nucleotide binding]; other site 1286404005273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404005274 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404005275 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404005276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404005277 AAA domain; Region: AAA_23; pfam13476 1286404005278 Walker A/P-loop; other site 1286404005279 ATP binding site [chemical binding]; other site 1286404005280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404005281 Walker B; other site 1286404005282 D-loop; other site 1286404005283 H-loop/switch region; other site 1286404005284 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1286404005285 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404005286 active site 1286404005287 metal binding site [ion binding]; metal-binding site 1286404005288 DNA binding site [nucleotide binding] 1286404005289 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1286404005290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404005291 ATP binding site [chemical binding]; other site 1286404005292 putative Mg++ binding site [ion binding]; other site 1286404005293 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1286404005294 ATP-binding site [chemical binding]; other site 1286404005295 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 1286404005296 nucleotide binding site [chemical binding]; other site 1286404005297 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 1286404005298 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1286404005299 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1286404005300 active site 1286404005301 substrate binding site [chemical binding]; other site 1286404005302 catalytic site [active] 1286404005303 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1286404005304 active site 1286404005305 DNA binding site [nucleotide binding] 1286404005306 catalytic site [active] 1286404005307 dUTPase; Region: dUTPase_2; pfam08761 1286404005308 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1286404005309 active site 1286404005310 homodimer interface [polypeptide binding]; other site 1286404005311 metal binding site [ion binding]; metal-binding site 1286404005312 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl15779 1286404005313 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1286404005314 DNA methylase; Region: N6_N4_Mtase; pfam01555 1286404005315 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 1286404005316 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404005317 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404005318 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286404005319 catalytic residues [active] 1286404005320 catalytic nucleophile [active] 1286404005321 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286404005322 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286404005323 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286404005324 Synaptic Site I dimer interface [polypeptide binding]; other site 1286404005325 DNA binding site [nucleotide binding] 1286404005326 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1286404005327 DNA-binding interface [nucleotide binding]; DNA binding site 1286404005328 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 1286404005329 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1286404005330 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1286404005331 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1286404005332 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1286404005333 Head fiber protein; Region: Phage_head_fibr; pfam11133 1286404005334 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 1286404005335 Phage protein; Region: DUF3647; pfam12363 1286404005336 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1286404005337 Phage-related protein [Function unknown]; Region: COG5412 1286404005338 Phage tail protein; Region: Sipho_tail; pfam05709 1286404005339 Phage tail protein; Region: Sipho_tail; cl17486 1286404005340 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1286404005341 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1286404005342 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1286404005343 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404005344 active site 1286404005345 catalytic residues [active] 1286404005346 DNA binding site [nucleotide binding] 1286404005347 Int/Topo IB signature motif; other site 1286404005348 Holin family; Region: Phage_holin_4; pfam05105 1286404005349 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1286404005350 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1286404005351 active site 1286404005352 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1286404005353 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1286404005354 non-specific DNA binding site [nucleotide binding]; other site 1286404005355 sequence-specific DNA binding site [nucleotide binding]; other site 1286404005356 salt bridge; other site 1286404005357 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404005358 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404005359 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404005360 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286404005361 catalytic residues [active] 1286404005362 catalytic nucleophile [active] 1286404005363 Recombinase; Region: Recombinase; pfam07508 1286404005364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404005365 Recombinase; Region: Recombinase; pfam07508 1286404005366 Amidase; Region: Amidase; cl11426 1286404005367 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286404005368 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1286404005369 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1286404005370 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404005371 NAD binding site [chemical binding]; other site 1286404005372 dimer interface [polypeptide binding]; other site 1286404005373 substrate binding site [chemical binding]; other site 1286404005374 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1286404005375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404005376 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286404005377 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1286404005378 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286404005379 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1286404005380 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 1286404005381 putative ligand binding site [chemical binding]; other site 1286404005382 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1286404005383 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1286404005384 Walker A/P-loop; other site 1286404005385 ATP binding site [chemical binding]; other site 1286404005386 Q-loop/lid; other site 1286404005387 ABC transporter signature motif; other site 1286404005388 Walker B; other site 1286404005389 D-loop; other site 1286404005390 H-loop/switch region; other site 1286404005391 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286404005392 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1286404005393 Walker A/P-loop; other site 1286404005394 ATP binding site [chemical binding]; other site 1286404005395 Q-loop/lid; other site 1286404005396 ABC transporter signature motif; other site 1286404005397 Walker B; other site 1286404005398 D-loop; other site 1286404005399 H-loop/switch region; other site 1286404005400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286404005401 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1286404005402 TM-ABC transporter signature motif; other site 1286404005403 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1286404005404 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1286404005405 TM-ABC transporter signature motif; other site 1286404005406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404005407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404005408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1286404005409 dimerization interface [polypeptide binding]; other site 1286404005410 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1286404005411 active site 1 [active] 1286404005412 dimer interface [polypeptide binding]; other site 1286404005413 hexamer interface [polypeptide binding]; other site 1286404005414 active site 2 [active] 1286404005415 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1286404005416 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404005417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404005418 putative Zn2+ binding site [ion binding]; other site 1286404005419 putative DNA binding site [nucleotide binding]; other site 1286404005420 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1286404005421 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1286404005422 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1286404005423 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1286404005424 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1286404005425 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1286404005426 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1286404005427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404005428 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1286404005429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404005430 Walker A/P-loop; other site 1286404005431 ATP binding site [chemical binding]; other site 1286404005432 Q-loop/lid; other site 1286404005433 ABC transporter signature motif; other site 1286404005434 Walker B; other site 1286404005435 D-loop; other site 1286404005436 H-loop/switch region; other site 1286404005437 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1286404005438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404005439 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1286404005440 Walker A/P-loop; other site 1286404005441 ATP binding site [chemical binding]; other site 1286404005442 Q-loop/lid; other site 1286404005443 ABC transporter signature motif; other site 1286404005444 Walker B; other site 1286404005445 D-loop; other site 1286404005446 H-loop/switch region; other site 1286404005447 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1286404005448 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404005449 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1286404005450 active site 1286404005451 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404005452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404005453 active site 1286404005454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404005455 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404005456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1286404005457 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1286404005458 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1286404005459 inhibitor-cofactor binding pocket; inhibition site 1286404005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005461 catalytic residue [active] 1286404005462 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286404005463 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1286404005464 trimer interface [polypeptide binding]; other site 1286404005465 active site 1286404005466 substrate binding site [chemical binding]; other site 1286404005467 CoA binding site [chemical binding]; other site 1286404005468 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1286404005469 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1286404005470 putative dimer interface [polypeptide binding]; other site 1286404005471 catalytic triad [active] 1286404005472 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404005473 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286404005474 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1286404005475 dimer interface [polypeptide binding]; other site 1286404005476 FMN binding site [chemical binding]; other site 1286404005477 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404005478 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404005479 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404005480 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404005481 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404005482 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1286404005483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404005484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404005485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404005486 Walker A/P-loop; other site 1286404005487 ATP binding site [chemical binding]; other site 1286404005488 Q-loop/lid; other site 1286404005489 ABC transporter signature motif; other site 1286404005490 Walker B; other site 1286404005491 D-loop; other site 1286404005492 H-loop/switch region; other site 1286404005493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404005494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404005495 active site 1286404005496 phosphorylation site [posttranslational modification] 1286404005497 intermolecular recognition site; other site 1286404005498 dimerization interface [polypeptide binding]; other site 1286404005499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404005500 DNA binding site [nucleotide binding] 1286404005501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404005502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404005503 dimerization interface [polypeptide binding]; other site 1286404005504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404005505 dimer interface [polypeptide binding]; other site 1286404005506 phosphorylation site [posttranslational modification] 1286404005507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404005508 ATP binding site [chemical binding]; other site 1286404005509 Mg2+ binding site [ion binding]; other site 1286404005510 G-X-G motif; other site 1286404005511 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1286404005512 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1286404005513 classical (c) SDRs; Region: SDR_c; cd05233 1286404005514 NAD(P) binding site [chemical binding]; other site 1286404005515 active site 1286404005516 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1286404005517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404005518 S-adenosylmethionine binding site [chemical binding]; other site 1286404005519 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1286404005520 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404005521 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1286404005522 NodB motif; other site 1286404005523 active site 1286404005524 catalytic site [active] 1286404005525 metal binding site [ion binding]; metal-binding site 1286404005526 SdpI/YhfL protein family; Region: SdpI; pfam13630 1286404005527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 1286404005528 nudix motif; other site 1286404005529 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1286404005530 homoserine dehydrogenase; Provisional; Region: PRK06349 1286404005531 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1286404005532 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1286404005533 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1286404005534 threonine synthase; Reviewed; Region: PRK06721 1286404005535 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1286404005536 homodimer interface [polypeptide binding]; other site 1286404005537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005538 catalytic residue [active] 1286404005539 homoserine kinase; Provisional; Region: PRK01212 1286404005540 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1286404005541 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1286404005542 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1286404005543 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1286404005544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404005545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404005546 active site 1286404005547 phosphorylation site [posttranslational modification] 1286404005548 intermolecular recognition site; other site 1286404005549 dimerization interface [polypeptide binding]; other site 1286404005550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404005551 DNA binding site [nucleotide binding] 1286404005552 HAMP domain; Region: HAMP; pfam00672 1286404005553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404005554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404005555 dimer interface [polypeptide binding]; other site 1286404005556 phosphorylation site [posttranslational modification] 1286404005557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404005558 ATP binding site [chemical binding]; other site 1286404005559 Mg2+ binding site [ion binding]; other site 1286404005560 G-X-G motif; other site 1286404005561 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404005562 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1286404005563 NodB motif; other site 1286404005564 active site 1286404005565 catalytic site [active] 1286404005566 Zn binding site [ion binding]; other site 1286404005567 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1286404005568 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1286404005569 MgtC family; Region: MgtC; pfam02308 1286404005570 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286404005571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005572 Coenzyme A binding pocket [chemical binding]; other site 1286404005573 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1286404005574 IucA / IucC family; Region: IucA_IucC; pfam04183 1286404005575 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1286404005576 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1286404005577 IucA / IucC family; Region: IucA_IucC; pfam04183 1286404005578 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1286404005579 acyl-CoA synthetase; Validated; Region: PRK08308 1286404005580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286404005581 acyl-activating enzyme (AAE) consensus motif; other site 1286404005582 AMP binding site [chemical binding]; other site 1286404005583 active site 1286404005584 CoA binding site [chemical binding]; other site 1286404005585 acyl carrier protein; Provisional; Region: PRK07639 1286404005586 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286404005587 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1286404005588 Metal-binding active site; metal-binding site 1286404005589 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404005590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404005592 putative substrate translocation pore; other site 1286404005593 Lysine efflux permease [General function prediction only]; Region: COG1279 1286404005594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404005595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404005596 DNA-binding site [nucleotide binding]; DNA binding site 1286404005597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404005598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005599 homodimer interface [polypeptide binding]; other site 1286404005600 catalytic residue [active] 1286404005601 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 1286404005602 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1286404005603 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1286404005604 active site 1286404005605 nucleophile elbow; other site 1286404005606 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1286404005607 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286404005608 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 1286404005609 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1286404005610 nudix motif; other site 1286404005611 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1286404005612 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1286404005613 homodimer interface [polypeptide binding]; other site 1286404005614 NAD binding pocket [chemical binding]; other site 1286404005615 ATP binding pocket [chemical binding]; other site 1286404005616 Mg binding site [ion binding]; other site 1286404005617 active-site loop [active] 1286404005618 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286404005619 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404005620 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1286404005621 active site 1286404005622 catalytic residues [active] 1286404005623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404005624 dimerization interface [polypeptide binding]; other site 1286404005625 putative DNA binding site [nucleotide binding]; other site 1286404005626 putative Zn2+ binding site [ion binding]; other site 1286404005627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404005628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404005629 active site 1286404005630 catalytic tetrad [active] 1286404005631 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404005632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005633 putative substrate translocation pore; other site 1286404005634 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1286404005635 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1286404005636 DinB superfamily; Region: DinB_2; pfam12867 1286404005637 GTPase RsgA; Reviewed; Region: PRK01889 1286404005638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286404005639 RNA binding site [nucleotide binding]; other site 1286404005640 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1286404005641 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1286404005642 GTP/Mg2+ binding site [chemical binding]; other site 1286404005643 G4 box; other site 1286404005644 G5 box; other site 1286404005645 G1 box; other site 1286404005646 Switch I region; other site 1286404005647 G2 box; other site 1286404005648 G3 box; other site 1286404005649 Switch II region; other site 1286404005650 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1286404005651 Cache domain; Region: Cache_1; pfam02743 1286404005652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404005653 dimerization interface [polypeptide binding]; other site 1286404005654 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404005655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404005656 dimer interface [polypeptide binding]; other site 1286404005657 putative CheW interface [polypeptide binding]; other site 1286404005658 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 1286404005659 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1286404005660 Ferritin-like domain; Region: Ferritin; pfam00210 1286404005661 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1286404005662 dimerization interface [polypeptide binding]; other site 1286404005663 DPS ferroxidase diiron center [ion binding]; other site 1286404005664 ion pore; other site 1286404005665 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 1286404005666 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1286404005667 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1286404005668 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1286404005669 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 1286404005670 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1286404005671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404005672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404005673 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404005674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404005675 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404005676 active site 1286404005677 catalytic tetrad [active] 1286404005678 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1286404005679 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1286404005680 P-loop, Walker A motif; other site 1286404005681 Base recognition motif; other site 1286404005682 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1286404005683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404005684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005685 Coenzyme A binding pocket [chemical binding]; other site 1286404005686 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1286404005687 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1286404005688 metal binding site [ion binding]; metal-binding site 1286404005689 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1286404005690 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286404005691 NAD binding site [chemical binding]; other site 1286404005692 active site 1286404005693 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286404005694 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1286404005695 active site 1286404005696 FMN binding site [chemical binding]; other site 1286404005697 substrate binding site [chemical binding]; other site 1286404005698 homotetramer interface [polypeptide binding]; other site 1286404005699 catalytic residue [active] 1286404005700 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1286404005701 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1286404005702 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404005703 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404005704 peptide binding site [polypeptide binding]; other site 1286404005705 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1286404005706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404005707 active site 1286404005708 metal binding site [ion binding]; metal-binding site 1286404005709 short chain dehydrogenase; Provisional; Region: PRK08309 1286404005710 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404005711 catalytic core [active] 1286404005712 CotH protein; Region: CotH; pfam08757 1286404005713 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1286404005714 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1286404005715 nudix motif; other site 1286404005716 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404005717 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404005718 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286404005719 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1286404005720 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1286404005721 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1286404005722 Cl binding site [ion binding]; other site 1286404005723 oligomer interface [polypeptide binding]; other site 1286404005724 Predicted permeases [General function prediction only]; Region: COG0701 1286404005725 Predicted membrane protein [Function unknown]; Region: COG3689 1286404005726 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1286404005727 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1286404005728 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1286404005729 putative active site [active] 1286404005730 catalytic site [active] 1286404005731 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1286404005732 putative active site [active] 1286404005733 catalytic site [active] 1286404005734 Coat F domain; Region: Coat_F; pfam07875 1286404005735 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1286404005736 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286404005737 NAD binding site [chemical binding]; other site 1286404005738 substrate binding site [chemical binding]; other site 1286404005739 putative active site [active] 1286404005740 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1286404005741 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286404005742 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286404005743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286404005744 Transporter associated domain; Region: CorC_HlyC; smart01091 1286404005745 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404005746 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404005747 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1286404005748 FOG: CBS domain [General function prediction only]; Region: COG0517 1286404005749 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1286404005750 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1286404005751 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1286404005752 dimer interface [polypeptide binding]; other site 1286404005753 putative tRNA-binding site [nucleotide binding]; other site 1286404005754 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1286404005755 DinB superfamily; Region: DinB_2; pfam12867 1286404005756 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1286404005757 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1286404005758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404005759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005760 Coenzyme A binding pocket [chemical binding]; other site 1286404005761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404005762 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1286404005763 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1286404005764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1286404005765 nudix motif; other site 1286404005766 amidase; Provisional; Region: PRK06828 1286404005767 Amidase; Region: Amidase; pfam01425 1286404005768 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404005769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005770 putative substrate translocation pore; other site 1286404005771 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1286404005772 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1286404005773 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1286404005774 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1286404005775 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1286404005776 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404005777 catalytic core [active] 1286404005778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404005779 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404005780 active site 1286404005781 motif I; other site 1286404005782 motif II; other site 1286404005783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404005784 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404005785 MarR family; Region: MarR; pfam01047 1286404005786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404005788 putative substrate translocation pore; other site 1286404005789 DinB superfamily; Region: DinB_2; pfam12867 1286404005790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1286404005791 alanine racemase; Reviewed; Region: alr; PRK00053 1286404005792 active site 1286404005793 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286404005794 dimer interface [polypeptide binding]; other site 1286404005795 substrate binding site [chemical binding]; other site 1286404005796 catalytic residues [active] 1286404005797 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404005798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404005799 S-adenosylmethionine binding site [chemical binding]; other site 1286404005800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005801 Coenzyme A binding pocket [chemical binding]; other site 1286404005802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005803 Coenzyme A binding pocket [chemical binding]; other site 1286404005804 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404005805 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1286404005806 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1286404005807 active site 1286404005808 TDP-binding site; other site 1286404005809 acceptor substrate-binding pocket; other site 1286404005810 homodimer interface [polypeptide binding]; other site 1286404005811 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404005812 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404005813 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404005814 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404005815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404005816 DNA-binding site [nucleotide binding]; DNA binding site 1286404005817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404005818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404005819 homodimer interface [polypeptide binding]; other site 1286404005820 catalytic residue [active] 1286404005821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005822 Coenzyme A binding pocket [chemical binding]; other site 1286404005823 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404005824 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1286404005825 active site 1286404005826 metal binding site [ion binding]; metal-binding site 1286404005827 Src Homology 3 domain superfamily; Region: SH3; cl17036 1286404005828 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404005829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005830 Coenzyme A binding pocket [chemical binding]; other site 1286404005831 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1286404005832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404005833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005834 Coenzyme A binding pocket [chemical binding]; other site 1286404005835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005836 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404005837 Coenzyme A binding pocket [chemical binding]; other site 1286404005838 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1286404005839 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1286404005840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404005841 Coenzyme A binding pocket [chemical binding]; other site 1286404005842 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1286404005843 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404005844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404005845 S-adenosylmethionine binding site [chemical binding]; other site 1286404005846 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1286404005847 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1286404005848 Potassium binding sites [ion binding]; other site 1286404005849 Cesium cation binding sites [ion binding]; other site 1286404005850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1286404005851 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286404005852 ATP binding site [chemical binding]; other site 1286404005853 putative Mg++ binding site [ion binding]; other site 1286404005854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404005855 nucleotide binding region [chemical binding]; other site 1286404005856 ATP-binding site [chemical binding]; other site 1286404005857 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1286404005858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404005859 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1286404005860 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404005861 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1286404005862 NADP binding site [chemical binding]; other site 1286404005863 dimer interface [polypeptide binding]; other site 1286404005864 RNA polymerase sigma factor; Provisional; Region: PRK12543 1286404005865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404005866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404005867 DNA binding residues [nucleotide binding] 1286404005868 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 1286404005869 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1286404005870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404005871 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 1286404005872 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1286404005873 catalytic residues [active] 1286404005874 dimer interface [polypeptide binding]; other site 1286404005875 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1286404005876 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1286404005877 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1286404005878 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1286404005879 Protein of unknown function DUF58; Region: DUF58; pfam01882 1286404005880 MoxR-like ATPases [General function prediction only]; Region: COG0714 1286404005881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404005882 Walker A motif; other site 1286404005883 ATP binding site [chemical binding]; other site 1286404005884 Walker B motif; other site 1286404005885 arginine finger; other site 1286404005886 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1286404005887 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1286404005888 [4Fe-4S] binding site [ion binding]; other site 1286404005889 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286404005890 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286404005891 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1286404005892 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1286404005893 molybdopterin cofactor binding site; other site 1286404005894 nitrate reductase, beta subunit; Region: narH; TIGR01660 1286404005895 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1286404005896 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1286404005897 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286404005898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286404005899 ligand binding site [chemical binding]; other site 1286404005900 flexible hinge region; other site 1286404005901 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1286404005902 putative switch regulator; other site 1286404005903 non-specific DNA interactions [nucleotide binding]; other site 1286404005904 DNA binding site [nucleotide binding] 1286404005905 sequence specific DNA binding site [nucleotide binding]; other site 1286404005906 putative cAMP binding site [chemical binding]; other site 1286404005907 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1286404005908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404005909 FeS/SAM binding site; other site 1286404005910 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1286404005911 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1286404005912 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286404005913 ATP binding site [chemical binding]; other site 1286404005914 substrate interface [chemical binding]; other site 1286404005915 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1286404005916 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1286404005917 dimer interface [polypeptide binding]; other site 1286404005918 putative functional site; other site 1286404005919 putative MPT binding site; other site 1286404005920 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1286404005921 MoaE homodimer interface [polypeptide binding]; other site 1286404005922 MoaD interaction [polypeptide binding]; other site 1286404005923 active site residues [active] 1286404005924 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1286404005925 MoaE interaction surface [polypeptide binding]; other site 1286404005926 MoeB interaction surface [polypeptide binding]; other site 1286404005927 thiocarboxylated glycine; other site 1286404005928 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1286404005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404005930 putative substrate translocation pore; other site 1286404005931 Predicted permeases [General function prediction only]; Region: COG0679 1286404005932 precorrin-2 dehydrogenase; Validated; Region: PRK06719 1286404005933 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1286404005934 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1286404005935 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1286404005936 putative active site [active] 1286404005937 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1286404005938 putative active site [active] 1286404005939 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1286404005940 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1286404005941 active site 1286404005942 SAM binding site [chemical binding]; other site 1286404005943 homodimer interface [polypeptide binding]; other site 1286404005944 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1286404005945 [2Fe-2S] cluster binding site [ion binding]; other site 1286404005946 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1286404005947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404005948 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286404005949 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286404005950 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1286404005951 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1286404005952 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1286404005953 Hemerythrin-like domain; Region: Hr-like; cd12108 1286404005954 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1286404005955 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1286404005956 PGAP1-like protein; Region: PGAP1; pfam07819 1286404005957 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1286404005958 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1286404005959 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1286404005960 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404005961 Zn2+ binding site [ion binding]; other site 1286404005962 Mg2+ binding site [ion binding]; other site 1286404005963 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1286404005964 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404005965 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404005966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404005967 ABC transporter; Region: ABC_tran_2; pfam12848 1286404005968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404005969 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1286404005970 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 1286404005971 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1286404005972 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1286404005973 dimer interface [polypeptide binding]; other site 1286404005974 ssDNA binding site [nucleotide binding]; other site 1286404005975 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404005976 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1286404005977 Virulence factor; Region: Virulence_fact; pfam13769 1286404005978 HEAT repeats; Region: HEAT_2; pfam13646 1286404005979 HEAT repeats; Region: HEAT_2; pfam13646 1286404005980 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1286404005981 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1286404005982 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1286404005983 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1286404005984 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1286404005985 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1286404005986 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1286404005987 active site 1286404005988 HIGH motif; other site 1286404005989 KMSK motif region; other site 1286404005990 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1286404005991 tRNA binding surface [nucleotide binding]; other site 1286404005992 anticodon binding site; other site 1286404005993 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404005994 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286404005995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404005996 binding surface 1286404005997 TPR motif; other site 1286404005998 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1286404005999 putative active site [active] 1286404006000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006001 binding surface 1286404006002 TPR motif; other site 1286404006003 TPR repeat; Region: TPR_11; pfam13414 1286404006004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006005 binding surface 1286404006006 TPR motif; other site 1286404006007 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286404006008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006009 binding surface 1286404006010 TPR motif; other site 1286404006011 TPR repeat; Region: TPR_11; pfam13414 1286404006012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006013 binding surface 1286404006014 TPR motif; other site 1286404006015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006016 binding surface 1286404006017 TPR motif; other site 1286404006018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286404006019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006020 binding surface 1286404006021 TPR motif; other site 1286404006022 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1286404006023 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1286404006024 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1286404006025 HIGH motif; other site 1286404006026 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1286404006027 active site 1286404006028 KMSKS motif; other site 1286404006029 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1286404006030 tRNA binding surface [nucleotide binding]; other site 1286404006031 anticodon binding site; other site 1286404006032 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1286404006033 Protein of unknown function (DUF418); Region: DUF418; cl12135 1286404006034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404006035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404006036 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404006037 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404006038 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1286404006039 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1286404006040 Zn binding site [ion binding]; other site 1286404006041 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1286404006042 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286404006043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286404006044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286404006045 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1286404006046 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1286404006047 Dimer interface [polypeptide binding]; other site 1286404006048 anticodon binding site; other site 1286404006049 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1286404006050 homodimer interface [polypeptide binding]; other site 1286404006051 motif 1; other site 1286404006052 motif 2; other site 1286404006053 active site 1286404006054 motif 3; other site 1286404006055 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1286404006056 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1286404006057 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404006058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404006059 Walker A motif; other site 1286404006060 ATP binding site [chemical binding]; other site 1286404006061 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404006062 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404006063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1286404006064 active site 1286404006065 ATP binding site [chemical binding]; other site 1286404006066 substrate binding site [chemical binding]; other site 1286404006067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006068 binding surface 1286404006069 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286404006070 TPR motif; other site 1286404006071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404006072 binding surface 1286404006073 TPR motif; other site 1286404006074 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404006075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404006076 binding surface 1286404006077 TPR motif; other site 1286404006078 SseB protein; Region: SseB; cl06279 1286404006079 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1286404006080 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1286404006081 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1286404006082 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404006083 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286404006084 catalytic nucleophile [active] 1286404006085 Resolvase, N terminal domain; Region: Resolvase; smart00857 1286404006086 Recombinase; Region: Recombinase; pfam07508 1286404006087 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404006088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404006089 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404006090 GAD-like domain; Region: GAD-like; pfam08887 1286404006091 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1286404006092 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1286404006093 Na2 binding site [ion binding]; other site 1286404006094 putative substrate binding site 1 [chemical binding]; other site 1286404006095 Na binding site 1 [ion binding]; other site 1286404006096 putative substrate binding site 2 [chemical binding]; other site 1286404006097 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404006098 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1286404006099 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1286404006100 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286404006101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404006102 motif II; other site 1286404006103 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1286404006104 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1286404006105 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1286404006106 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1286404006107 putative active site [active] 1286404006108 metal binding site [ion binding]; metal-binding site 1286404006109 aspartate racemase; Region: asp_race; TIGR00035 1286404006110 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1286404006111 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1286404006112 homodimer interaction site [polypeptide binding]; other site 1286404006113 cofactor binding site; other site 1286404006114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404006115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006116 Coenzyme A binding pocket [chemical binding]; other site 1286404006117 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1286404006118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404006119 salt bridge; other site 1286404006120 non-specific DNA binding site [nucleotide binding]; other site 1286404006121 sequence-specific DNA binding site [nucleotide binding]; other site 1286404006122 hypothetical protein; Validated; Region: PRK06769 1286404006123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404006124 active site 1286404006125 motif I; other site 1286404006126 motif II; other site 1286404006127 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404006128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006129 Coenzyme A binding pocket [chemical binding]; other site 1286404006130 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404006131 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404006132 Walker A/P-loop; other site 1286404006133 ATP binding site [chemical binding]; other site 1286404006134 Q-loop/lid; other site 1286404006135 ABC transporter signature motif; other site 1286404006136 Walker B; other site 1286404006137 D-loop; other site 1286404006138 H-loop/switch region; other site 1286404006139 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1286404006140 YpjP-like protein; Region: YpjP; pfam14005 1286404006141 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286404006142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404006143 motif II; other site 1286404006144 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404006145 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404006146 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286404006147 active site 1286404006148 substrate binding site [chemical binding]; other site 1286404006149 ATP binding site [chemical binding]; other site 1286404006150 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404006151 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404006152 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1286404006153 thymidylate synthase; Region: thym_sym; TIGR03284 1286404006154 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1286404006155 dimerization interface [polypeptide binding]; other site 1286404006156 active site 1286404006157 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286404006158 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1286404006159 folate binding site [chemical binding]; other site 1286404006160 NADP+ binding site [chemical binding]; other site 1286404006161 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1286404006162 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404006163 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1286404006164 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404006165 azoreductase; Reviewed; Region: PRK00170 1286404006166 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404006167 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1286404006168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1286404006169 putative acyl-acceptor binding pocket; other site 1286404006170 Haemolysin-III related; Region: HlyIII; cl03831 1286404006171 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1286404006172 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1286404006173 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1286404006174 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1286404006175 EDD domain protein, DegV family; Region: DegV; TIGR00762 1286404006176 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1286404006177 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286404006178 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1286404006179 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1286404006180 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1286404006181 Cu(I) binding site [ion binding]; other site 1286404006182 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286404006183 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1286404006184 putative dimer interface [polypeptide binding]; other site 1286404006185 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1286404006186 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286404006187 active site 1286404006188 dimer interface [polypeptide binding]; other site 1286404006189 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286404006190 Ligand Binding Site [chemical binding]; other site 1286404006191 Molecular Tunnel; other site 1286404006192 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404006193 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286404006194 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286404006195 active site 1286404006196 metal binding site [ion binding]; metal-binding site 1286404006197 Bacterial SH3 domain; Region: SH3_3; cl17532 1286404006198 Bacterial SH3 domain; Region: SH3_3; cl17532 1286404006199 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286404006200 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1286404006201 siderophore binding site; other site 1286404006202 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286404006203 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1286404006204 homodimer interface [polypeptide binding]; other site 1286404006205 substrate-cofactor binding pocket; other site 1286404006206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404006207 catalytic residue [active] 1286404006208 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1286404006209 FMN binding site [chemical binding]; other site 1286404006210 dimer interface [polypeptide binding]; other site 1286404006211 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404006212 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1286404006213 catalytic triad [active] 1286404006214 conserved cis-peptide bond; other site 1286404006215 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1286404006216 nudix motif; other site 1286404006217 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286404006218 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286404006219 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286404006220 GAF domain; Region: GAF; pfam01590 1286404006221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404006222 Histidine kinase; Region: HisKA_3; pfam07730 1286404006223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404006224 ATP binding site [chemical binding]; other site 1286404006225 Mg2+ binding site [ion binding]; other site 1286404006226 G-X-G motif; other site 1286404006227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404006228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404006229 active site 1286404006230 phosphorylation site [posttranslational modification] 1286404006231 intermolecular recognition site; other site 1286404006232 dimerization interface [polypeptide binding]; other site 1286404006233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404006234 DNA binding residues [nucleotide binding] 1286404006235 dimerization interface [polypeptide binding]; other site 1286404006236 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1286404006237 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286404006238 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1286404006239 putative active site [active] 1286404006240 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286404006241 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286404006242 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1286404006243 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1286404006244 NAD binding site [chemical binding]; other site 1286404006245 substrate binding site [chemical binding]; other site 1286404006246 catalytic Zn binding site [ion binding]; other site 1286404006247 tetramer interface [polypeptide binding]; other site 1286404006248 structural Zn binding site [ion binding]; other site 1286404006249 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404006250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404006251 dimer interface [polypeptide binding]; other site 1286404006252 conserved gate region; other site 1286404006253 ABC-ATPase subunit interface; other site 1286404006254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286404006255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404006256 Integrase core domain; Region: rve; pfam00665 1286404006257 transposase/IS protein; Provisional; Region: PRK09183 1286404006258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404006259 Walker A motif; other site 1286404006260 ATP binding site [chemical binding]; other site 1286404006261 Walker B motif; other site 1286404006262 arginine finger; other site 1286404006263 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1286404006264 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1286404006265 N- and C-terminal domain interface [polypeptide binding]; other site 1286404006266 active site 1286404006267 catalytic site [active] 1286404006268 metal binding site [ion binding]; metal-binding site 1286404006269 carbohydrate binding site [chemical binding]; other site 1286404006270 ATP binding site [chemical binding]; other site 1286404006271 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1286404006272 GntP family permease; Region: GntP_permease; pfam02447 1286404006273 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1286404006274 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286404006275 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1286404006276 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404006277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404006278 active site 1286404006279 Predicted flavoprotein [General function prediction only]; Region: COG0431 1286404006280 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404006281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006282 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404006283 putative substrate translocation pore; other site 1286404006284 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286404006285 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286404006286 putative active site [active] 1286404006287 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1286404006288 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1286404006289 Walker A/P-loop; other site 1286404006290 ATP binding site [chemical binding]; other site 1286404006291 Q-loop/lid; other site 1286404006292 ABC transporter signature motif; other site 1286404006293 Walker B; other site 1286404006294 D-loop; other site 1286404006295 H-loop/switch region; other site 1286404006296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404006297 dimer interface [polypeptide binding]; other site 1286404006298 conserved gate region; other site 1286404006299 ABC-ATPase subunit interface; other site 1286404006300 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1286404006301 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1286404006302 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1286404006303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286404006304 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1286404006305 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1286404006306 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404006307 DNA binding residues [nucleotide binding] 1286404006308 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286404006309 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286404006310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286404006311 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1286404006312 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286404006313 NAD(P) binding site [chemical binding]; other site 1286404006314 catalytic residues [active] 1286404006315 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1286404006316 Histidine kinase N terminal; Region: HisK_N; pfam09385 1286404006317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404006318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404006319 dimer interface [polypeptide binding]; other site 1286404006320 phosphorylation site [posttranslational modification] 1286404006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404006322 ATP binding site [chemical binding]; other site 1286404006323 Mg2+ binding site [ion binding]; other site 1286404006324 G-X-G motif; other site 1286404006325 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1286404006326 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1286404006327 hypothetical protein; Provisional; Region: PRK06917 1286404006328 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404006329 inhibitor-cofactor binding pocket; inhibition site 1286404006330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404006331 catalytic residue [active] 1286404006332 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1286404006333 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1286404006334 acetylornithine deacetylase; Validated; Region: PRK06915 1286404006335 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1286404006336 metal binding site [ion binding]; metal-binding site 1286404006337 dimer interface [polypeptide binding]; other site 1286404006338 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1286404006339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404006340 Coenzyme A binding pocket [chemical binding]; other site 1286404006341 PAS fold; Region: PAS_4; pfam08448 1286404006342 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1286404006343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404006344 Walker A motif; other site 1286404006345 ATP binding site [chemical binding]; other site 1286404006346 Walker B motif; other site 1286404006347 arginine finger; other site 1286404006348 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286404006349 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1286404006350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404006351 FeS/SAM binding site; other site 1286404006352 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1286404006353 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1286404006354 toxin interface [polypeptide binding]; other site 1286404006355 Zn binding site [ion binding]; other site 1286404006356 hypothetical protein; Provisional; Region: PRK13672 1286404006357 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 1286404006358 YozD-like protein; Region: YozD; pfam14162 1286404006359 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1286404006360 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1286404006361 active site 1286404006362 ATP binding site [chemical binding]; other site 1286404006363 substrate binding site [chemical binding]; other site 1286404006364 activation loop (A-loop); other site 1286404006365 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1286404006366 SpoOM protein; Region: Spo0M; pfam07070 1286404006367 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286404006368 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1286404006369 active site 1286404006370 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286404006371 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1286404006372 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404006373 catalytic residues [active] 1286404006374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404006375 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404006376 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 1286404006377 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1286404006378 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1286404006379 active site 1286404006380 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1286404006381 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286404006382 YolD-like protein; Region: YolD; pfam08863 1286404006383 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1286404006384 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1286404006385 classical (c) SDRs; Region: SDR_c; cd05233 1286404006386 NAD(P) binding site [chemical binding]; other site 1286404006387 active site 1286404006388 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1286404006389 KTSC domain; Region: KTSC; pfam13619 1286404006390 Transglycosylase; Region: Transgly; pfam00912 1286404006391 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1286404006392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404006393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404006395 putative substrate translocation pore; other site 1286404006396 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1286404006397 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1286404006398 dimer interface [polypeptide binding]; other site 1286404006399 Citrate synthase; Region: Citrate_synt; pfam00285 1286404006400 active site 1286404006401 coenzyme A binding site [chemical binding]; other site 1286404006402 citrylCoA binding site [chemical binding]; other site 1286404006403 oxalacetate/citrate binding site [chemical binding]; other site 1286404006404 catalytic triad [active] 1286404006405 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1286404006406 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1286404006407 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1286404006408 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1286404006409 tetramer interface [polypeptide binding]; other site 1286404006410 active site 1286404006411 Mg2+/Mn2+ binding site [ion binding]; other site 1286404006412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286404006413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404006414 active site 1286404006415 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286404006416 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286404006417 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1286404006418 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1286404006419 tetrameric interface [polypeptide binding]; other site 1286404006420 NAD binding site [chemical binding]; other site 1286404006421 catalytic residues [active] 1286404006422 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286404006423 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1286404006424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286404006425 substrate binding site [chemical binding]; other site 1286404006426 oxyanion hole (OAH) forming residues; other site 1286404006427 trimer interface [polypeptide binding]; other site 1286404006428 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1286404006429 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1286404006430 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1286404006431 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1286404006432 active site 1286404006433 metal binding site [ion binding]; metal-binding site 1286404006434 DNA binding site [nucleotide binding] 1286404006435 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1286404006436 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1286404006437 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1286404006438 Walker A/P-loop; other site 1286404006439 ATP binding site [chemical binding]; other site 1286404006440 Q-loop/lid; other site 1286404006441 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1286404006442 ABC transporter signature motif; other site 1286404006443 Walker B; other site 1286404006444 D-loop; other site 1286404006445 H-loop/switch region; other site 1286404006446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404006447 dimerization interface [polypeptide binding]; other site 1286404006448 putative DNA binding site [nucleotide binding]; other site 1286404006449 putative Zn2+ binding site [ion binding]; other site 1286404006450 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1286404006451 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1286404006452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006453 putative substrate translocation pore; other site 1286404006454 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1286404006455 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1286404006456 putative NAD(P) binding site [chemical binding]; other site 1286404006457 active site 1286404006458 isochorismate synthase DhbC; Validated; Region: PRK06923 1286404006459 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1286404006460 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1286404006461 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1286404006462 acyl-activating enzyme (AAE) consensus motif; other site 1286404006463 active site 1286404006464 AMP binding site [chemical binding]; other site 1286404006465 substrate binding site [chemical binding]; other site 1286404006466 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1286404006467 hydrophobic substrate binding pocket; other site 1286404006468 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404006469 active site 1286404006470 conserved cis-peptide bond; other site 1286404006471 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1286404006472 Condensation domain; Region: Condensation; pfam00668 1286404006473 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1286404006474 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404006475 acyl-activating enzyme (AAE) consensus motif; other site 1286404006476 AMP binding site [chemical binding]; other site 1286404006477 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006478 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1286404006479 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404006480 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006481 acyl-activating enzyme (AAE) consensus motif; other site 1286404006482 AMP binding site [chemical binding]; other site 1286404006483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006484 MbtH-like protein; Region: MbtH; pfam03621 1286404006485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404006487 putative substrate translocation pore; other site 1286404006488 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1286404006489 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1286404006490 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286404006491 IHF dimer interface [polypeptide binding]; other site 1286404006492 IHF - DNA interface [nucleotide binding]; other site 1286404006493 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1286404006494 DinB family; Region: DinB; cl17821 1286404006495 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1286404006496 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1286404006497 active site 1286404006498 catalytic triad [active] 1286404006499 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404006500 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1286404006501 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1286404006502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404006503 RNA binding surface [nucleotide binding]; other site 1286404006504 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1286404006505 probable active site [active] 1286404006506 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1286404006507 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1286404006508 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286404006509 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1286404006510 active site 1286404006511 dimer interface [polypeptide binding]; other site 1286404006512 motif 1; other site 1286404006513 motif 2; other site 1286404006514 motif 3; other site 1286404006515 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1286404006516 anticodon binding site; other site 1286404006517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404006518 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404006519 Walker A/P-loop; other site 1286404006520 ATP binding site [chemical binding]; other site 1286404006521 Q-loop/lid; other site 1286404006522 ABC transporter signature motif; other site 1286404006523 Walker B; other site 1286404006524 D-loop; other site 1286404006525 H-loop/switch region; other site 1286404006526 FtsX-like permease family; Region: FtsX; pfam02687 1286404006527 FtsX-like permease family; Region: FtsX; pfam02687 1286404006528 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404006529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286404006531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1286404006532 pyruvate oxidase; Provisional; Region: PRK08611 1286404006533 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1286404006534 PYR/PP interface [polypeptide binding]; other site 1286404006535 dimer interface [polypeptide binding]; other site 1286404006536 tetramer interface [polypeptide binding]; other site 1286404006537 TPP binding site [chemical binding]; other site 1286404006538 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286404006539 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1286404006540 TPP-binding site [chemical binding]; other site 1286404006541 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1286404006542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404006543 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1286404006544 active site 1286404006545 dimerization interface [polypeptide binding]; other site 1286404006546 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 1286404006547 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1286404006548 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1286404006549 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286404006550 ligand binding site [chemical binding]; other site 1286404006551 flexible hinge region; other site 1286404006552 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286404006553 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1286404006554 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1286404006555 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1286404006556 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286404006557 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1286404006558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286404006559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404006560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404006561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404006562 MMPL family; Region: MMPL; pfam03176 1286404006563 MMPL family; Region: MMPL; pfam03176 1286404006564 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 1286404006565 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 1286404006566 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1286404006567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006568 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404006569 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404006570 Coenzyme A binding pocket [chemical binding]; other site 1286404006571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404006572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006573 Coenzyme A binding pocket [chemical binding]; other site 1286404006574 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1286404006575 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1286404006576 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1286404006577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006578 Coenzyme A binding pocket [chemical binding]; other site 1286404006579 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404006580 EamA-like transporter family; Region: EamA; pfam00892 1286404006581 EamA-like transporter family; Region: EamA; pfam00892 1286404006582 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286404006583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404006584 non-specific DNA binding site [nucleotide binding]; other site 1286404006585 salt bridge; other site 1286404006586 sequence-specific DNA binding site [nucleotide binding]; other site 1286404006587 Cupin domain; Region: Cupin_2; pfam07883 1286404006588 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404006589 protoporphyrinogen oxidase; Provisional; Region: PRK12416 1286404006590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404006591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404006592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404006593 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404006594 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1286404006595 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404006596 DNA-binding site [nucleotide binding]; DNA binding site 1286404006597 RNA-binding motif; other site 1286404006598 CAAX protease self-immunity; Region: Abi; pfam02517 1286404006599 AAA domain; Region: AAA_17; pfam13207 1286404006600 AAA domain; Region: AAA_18; pfam13238 1286404006601 hypothetical protein; Provisional; Region: PRK06770 1286404006602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404006603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404006604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404006605 dimerization interface [polypeptide binding]; other site 1286404006606 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 1286404006607 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286404006608 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286404006609 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1286404006610 active site 1286404006611 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1286404006612 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1286404006613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404006614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404006615 dimerization interface [polypeptide binding]; other site 1286404006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1286404006617 MOSC domain; Region: MOSC; pfam03473 1286404006618 3-alpha domain; Region: 3-alpha; pfam03475 1286404006619 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1286404006620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006621 Coenzyme A binding pocket [chemical binding]; other site 1286404006622 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1286404006623 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404006624 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404006625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404006626 Walker A/P-loop; other site 1286404006627 ATP binding site [chemical binding]; other site 1286404006628 Q-loop/lid; other site 1286404006629 ABC transporter signature motif; other site 1286404006630 Walker B; other site 1286404006631 D-loop; other site 1286404006632 H-loop/switch region; other site 1286404006633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404006634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404006635 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1286404006636 Walker A/P-loop; other site 1286404006637 ATP binding site [chemical binding]; other site 1286404006638 Q-loop/lid; other site 1286404006639 ABC transporter signature motif; other site 1286404006640 Walker B; other site 1286404006641 D-loop; other site 1286404006642 H-loop/switch region; other site 1286404006643 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1286404006644 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1286404006645 Septum formation initiator; Region: DivIC; cl17659 1286404006646 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 1286404006647 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1286404006648 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1286404006649 Int/Topo IB signature motif; other site 1286404006650 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404006651 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286404006652 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286404006653 Homeodomain-like domain; Region: HTH_23; pfam13384 1286404006654 Phage terminase, small subunit; Region: Terminase_4; cl01525 1286404006655 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1286404006656 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404006657 amidase catalytic site [active] 1286404006658 Zn binding residues [ion binding]; other site 1286404006659 substrate binding site [chemical binding]; other site 1286404006660 Bacterial SH3 domain; Region: SH3_3; cl17532 1286404006661 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404006662 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1286404006663 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1286404006664 LysE type translocator; Region: LysE; cl00565 1286404006665 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1286404006666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404006667 non-specific DNA binding site [nucleotide binding]; other site 1286404006668 salt bridge; other site 1286404006669 sequence-specific DNA binding site [nucleotide binding]; other site 1286404006670 Cupin domain; Region: Cupin_2; pfam07883 1286404006671 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1286404006672 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1286404006673 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1286404006674 Cupin; Region: Cupin_1; smart00835 1286404006675 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1286404006676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404006677 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1286404006678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404006679 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286404006680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286404006681 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1286404006682 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 1286404006683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1286404006684 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1286404006685 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286404006686 active site 1286404006687 P-loop; other site 1286404006688 phosphorylation site [posttranslational modification] 1286404006689 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1286404006690 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286404006691 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1286404006692 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1286404006693 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1286404006694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1286404006695 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1286404006696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404006697 catalytic residue [active] 1286404006698 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1286404006699 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1286404006700 tetramer interface [polypeptide binding]; other site 1286404006701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404006702 catalytic residue [active] 1286404006703 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404006704 MarR family; Region: MarR; pfam01047 1286404006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404006707 putative substrate translocation pore; other site 1286404006708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404006709 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1286404006710 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286404006711 ATP binding site [chemical binding]; other site 1286404006712 Mg++ binding site [ion binding]; other site 1286404006713 motif III; other site 1286404006714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404006715 nucleotide binding region [chemical binding]; other site 1286404006716 ATP-binding site [chemical binding]; other site 1286404006717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404006718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404006719 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404006720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006721 putative substrate translocation pore; other site 1286404006722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404006723 Q-loop/lid; other site 1286404006724 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404006725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404006726 S-adenosylmethionine binding site [chemical binding]; other site 1286404006727 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1286404006728 dimer interface [polypeptide binding]; other site 1286404006729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404006730 S-adenosylmethionine binding site [chemical binding]; other site 1286404006731 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1286404006732 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1286404006733 dimer interface [polypeptide binding]; other site 1286404006734 PYR/PP interface [polypeptide binding]; other site 1286404006735 TPP binding site [chemical binding]; other site 1286404006736 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1286404006737 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1286404006738 TPP-binding site [chemical binding]; other site 1286404006739 dimer interface [polypeptide binding]; other site 1286404006740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404006741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404006742 putative DNA binding site [nucleotide binding]; other site 1286404006743 putative Zn2+ binding site [ion binding]; other site 1286404006744 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404006745 catalytic core [active] 1286404006746 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404006747 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1286404006748 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1286404006749 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1286404006750 metal binding site [ion binding]; metal-binding site 1286404006751 dimer interface [polypeptide binding]; other site 1286404006752 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1286404006753 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1286404006754 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1286404006755 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404006756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404006757 DNA binding residues [nucleotide binding] 1286404006758 dimerization interface [polypeptide binding]; other site 1286404006759 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404006760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404006761 non-specific DNA binding site [nucleotide binding]; other site 1286404006762 salt bridge; other site 1286404006763 sequence-specific DNA binding site [nucleotide binding]; other site 1286404006764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404006765 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404006766 Cut8; Region: Cut8; pfam08559 1286404006767 hypothetical protein; Provisional; Region: PRK10621 1286404006768 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404006769 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286404006770 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286404006771 trimer interface [polypeptide binding]; other site 1286404006772 active site 1286404006773 substrate binding site [chemical binding]; other site 1286404006774 CoA binding site [chemical binding]; other site 1286404006775 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286404006776 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404006777 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1286404006778 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1286404006779 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1286404006780 active site 1286404006781 catalytic triad [active] 1286404006782 oxyanion hole [active] 1286404006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404006784 putative substrate translocation pore; other site 1286404006785 Condensation domain; Region: Condensation; pfam00668 1286404006786 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404006787 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404006788 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006789 acyl-activating enzyme (AAE) consensus motif; other site 1286404006790 AMP binding site [chemical binding]; other site 1286404006791 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006792 Condensation domain; Region: Condensation; pfam00668 1286404006793 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404006794 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1286404006795 Condensation domain; Region: Condensation; pfam00668 1286404006796 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404006797 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006798 acyl-activating enzyme (AAE) consensus motif; other site 1286404006799 AMP binding site [chemical binding]; other site 1286404006800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006801 Condensation domain; Region: Condensation; pfam00668 1286404006802 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404006803 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404006804 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1286404006805 acyl-activating enzyme (AAE) consensus motif; other site 1286404006806 AMP binding site [chemical binding]; other site 1286404006807 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006808 Condensation domain; Region: Condensation; pfam00668 1286404006809 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404006810 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404006811 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006812 acyl-activating enzyme (AAE) consensus motif; other site 1286404006813 AMP binding site [chemical binding]; other site 1286404006814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006815 peptide synthase; Provisional; Region: PRK12467 1286404006816 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404006817 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006818 acyl-activating enzyme (AAE) consensus motif; other site 1286404006819 AMP binding site [chemical binding]; other site 1286404006820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006821 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404006822 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006823 acyl-activating enzyme (AAE) consensus motif; other site 1286404006824 AMP binding site [chemical binding]; other site 1286404006825 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006826 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1286404006827 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404006828 acyl-activating enzyme (AAE) consensus motif; other site 1286404006829 AMP binding site [chemical binding]; other site 1286404006830 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404006831 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1286404006832 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1286404006833 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1286404006834 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1286404006835 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1286404006836 transmembrane helices; other site 1286404006837 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404006838 amino acid carrier protein; Region: agcS; TIGR00835 1286404006839 glutaminase; Reviewed; Region: PRK12357 1286404006840 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1286404006841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404006842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404006843 ATP binding site [chemical binding]; other site 1286404006844 Mg2+ binding site [ion binding]; other site 1286404006845 G-X-G motif; other site 1286404006846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404006847 Response regulator receiver domain; Region: Response_reg; pfam00072 1286404006848 active site 1286404006849 phosphorylation site [posttranslational modification] 1286404006850 intermolecular recognition site; other site 1286404006851 dimerization interface [polypeptide binding]; other site 1286404006852 YcbB domain; Region: YcbB; pfam08664 1286404006853 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404006854 Spore germination protein; Region: Spore_permease; pfam03845 1286404006855 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404006856 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404006857 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 1286404006858 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1286404006859 amino acid transporter; Region: 2A0306; TIGR00909 1286404006860 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1286404006861 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1286404006862 GIY-YIG motif/motif A; other site 1286404006863 active site 1286404006864 catalytic site [active] 1286404006865 putative DNA binding site [nucleotide binding]; other site 1286404006866 metal binding site [ion binding]; metal-binding site 1286404006867 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 1286404006868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404006869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404006870 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404006871 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404006872 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404006873 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404006874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286404006875 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286404006876 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286404006877 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286404006878 PAS fold; Region: PAS_4; pfam08448 1286404006879 PAS domain S-box; Region: sensory_box; TIGR00229 1286404006880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404006881 putative active site [active] 1286404006882 heme pocket [chemical binding]; other site 1286404006883 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286404006884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404006885 putative active site [active] 1286404006886 heme pocket [chemical binding]; other site 1286404006887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404006888 dimer interface [polypeptide binding]; other site 1286404006889 phosphorylation site [posttranslational modification] 1286404006890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404006891 ATP binding site [chemical binding]; other site 1286404006892 Mg2+ binding site [ion binding]; other site 1286404006893 G-X-G motif; other site 1286404006894 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404006895 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404006896 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1286404006897 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1286404006898 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404006899 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1286404006900 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1286404006901 active site 1286404006902 nucleophile elbow; other site 1286404006903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404006904 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404006905 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404006906 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1286404006907 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1286404006908 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404006909 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1286404006910 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404006911 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1286404006912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404006913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404006914 DNA binding residues [nucleotide binding] 1286404006915 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1286404006916 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404006917 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404006918 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404006919 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404006920 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404006921 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404006922 beta-lactamase TEM; Provisional; Region: PRK15442 1286404006923 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286404006924 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404006925 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1286404006926 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404006927 putative active site [active] 1286404006928 putative metal binding site [ion binding]; other site 1286404006929 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1286404006930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404006931 Walker A/P-loop; other site 1286404006932 ATP binding site [chemical binding]; other site 1286404006933 Q-loop/lid; other site 1286404006934 ABC transporter signature motif; other site 1286404006935 Walker B; other site 1286404006936 D-loop; other site 1286404006937 H-loop/switch region; other site 1286404006938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286404006939 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1286404006940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404006941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404006942 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1286404006943 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1286404006944 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1286404006945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404006946 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1286404006947 FAD binding site [chemical binding]; other site 1286404006948 homotetramer interface [polypeptide binding]; other site 1286404006949 substrate binding pocket [chemical binding]; other site 1286404006950 catalytic base [active] 1286404006951 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1286404006952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286404006953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286404006954 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286404006955 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286404006956 carboxyltransferase (CT) interaction site; other site 1286404006957 biotinylation site [posttranslational modification]; other site 1286404006958 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1286404006959 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1286404006960 active site 1286404006961 catalytic residues [active] 1286404006962 metal binding site [ion binding]; metal-binding site 1286404006963 enoyl-CoA hydratase; Provisional; Region: PRK07657 1286404006964 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286404006965 substrate binding site [chemical binding]; other site 1286404006966 oxyanion hole (OAH) forming residues; other site 1286404006967 trimer interface [polypeptide binding]; other site 1286404006968 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1286404006969 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1286404006970 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1286404006971 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1286404006972 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 1286404006973 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 1286404006974 acyl-activating enzyme (AAE) consensus motif; other site 1286404006975 putative AMP binding site [chemical binding]; other site 1286404006976 putative active site [active] 1286404006977 putative CoA binding site [chemical binding]; other site 1286404006978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404006979 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404006980 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404006981 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404006982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404006983 Coenzyme A binding pocket [chemical binding]; other site 1286404006984 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 1286404006985 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286404006986 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404006987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404006988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404006989 dimer interface [polypeptide binding]; other site 1286404006990 phosphorylation site [posttranslational modification] 1286404006991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404006992 ATP binding site [chemical binding]; other site 1286404006993 Mg2+ binding site [ion binding]; other site 1286404006994 G-X-G motif; other site 1286404006995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404006996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404006997 active site 1286404006998 phosphorylation site [posttranslational modification] 1286404006999 intermolecular recognition site; other site 1286404007000 dimerization interface [polypeptide binding]; other site 1286404007001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404007002 DNA binding site [nucleotide binding] 1286404007003 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404007004 Zn2+ binding site [ion binding]; other site 1286404007005 Mg2+ binding site [ion binding]; other site 1286404007006 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1286404007007 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 1286404007008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007009 Coenzyme A binding pocket [chemical binding]; other site 1286404007010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286404007011 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404007012 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404007013 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404007014 active site 1286404007015 Zn binding site [ion binding]; other site 1286404007016 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1286404007017 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1286404007018 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1286404007019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286404007020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404007021 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404007022 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404007023 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404007024 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1286404007025 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1286404007026 active site 1286404007027 catalytic site [active] 1286404007028 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1286404007029 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1286404007030 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404007031 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404007032 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404007033 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404007034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1286404007035 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1286404007036 putative hydrophobic ligand binding site [chemical binding]; other site 1286404007037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404007038 AAA domain; Region: AAA_21; pfam13304 1286404007039 Walker A/P-loop; other site 1286404007040 ATP binding site [chemical binding]; other site 1286404007041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404007042 ABC transporter signature motif; other site 1286404007043 Walker B; other site 1286404007044 D-loop; other site 1286404007045 H-loop/switch region; other site 1286404007046 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 1286404007047 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1286404007048 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1286404007049 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1286404007050 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404007051 DNA binding residues [nucleotide binding] 1286404007052 drug binding residues [chemical binding]; other site 1286404007053 dimer interface [polypeptide binding]; other site 1286404007054 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1286404007055 short chain dehydrogenase; Provisional; Region: PRK07041 1286404007056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404007057 NAD(P) binding site [chemical binding]; other site 1286404007058 active site 1286404007059 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286404007060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404007061 Integrase core domain; Region: rve; pfam00665 1286404007062 transposase/IS protein; Provisional; Region: PRK09183 1286404007063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404007064 Walker A motif; other site 1286404007065 ATP binding site [chemical binding]; other site 1286404007066 Walker B motif; other site 1286404007067 arginine finger; other site 1286404007068 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404007069 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286404007070 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404007071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007072 S-adenosylmethionine binding site [chemical binding]; other site 1286404007073 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404007074 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404007075 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286404007076 active site 1286404007077 substrate binding site [chemical binding]; other site 1286404007078 ATP binding site [chemical binding]; other site 1286404007079 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404007080 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1286404007081 active site 1286404007082 ATP binding site [chemical binding]; other site 1286404007083 substrate binding site [chemical binding]; other site 1286404007084 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1286404007085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404007086 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1286404007087 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1286404007088 active site 1286404007089 Zn binding site [ion binding]; other site 1286404007090 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 1286404007091 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404007092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404007093 DNA-binding site [nucleotide binding]; DNA binding site 1286404007094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404007095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404007096 homodimer interface [polypeptide binding]; other site 1286404007097 catalytic residue [active] 1286404007098 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1286404007099 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1286404007100 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1286404007101 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286404007102 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1286404007103 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1286404007104 putative NAD(P) binding site [chemical binding]; other site 1286404007105 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404007106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404007107 NAD(P) binding site [chemical binding]; other site 1286404007108 active site 1286404007109 Predicted membrane protein [Function unknown]; Region: COG2323 1286404007110 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404007111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007112 S-adenosylmethionine binding site [chemical binding]; other site 1286404007113 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1286404007114 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286404007115 conserved cys residue [active] 1286404007116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007117 S-adenosylmethionine binding site [chemical binding]; other site 1286404007118 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1286404007119 Strictosidine synthase; Region: Str_synth; pfam03088 1286404007120 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1286404007121 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 1286404007122 active site 1286404007123 HIGH motif; other site 1286404007124 KMSKS motif; other site 1286404007125 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1286404007126 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1286404007127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404007128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404007129 active site 1286404007130 phosphorylation site [posttranslational modification] 1286404007131 intermolecular recognition site; other site 1286404007132 dimerization interface [polypeptide binding]; other site 1286404007133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404007134 DNA binding site [nucleotide binding] 1286404007135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404007136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1286404007137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404007138 ATP binding site [chemical binding]; other site 1286404007139 Mg2+ binding site [ion binding]; other site 1286404007140 G-X-G motif; other site 1286404007141 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1286404007142 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404007143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404007144 ABC transporter; Region: ABC_tran_2; pfam12848 1286404007145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404007146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404007147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404007148 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1286404007149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404007150 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404007151 Walker A/P-loop; other site 1286404007152 ATP binding site [chemical binding]; other site 1286404007153 Q-loop/lid; other site 1286404007154 ABC transporter signature motif; other site 1286404007155 Walker B; other site 1286404007156 D-loop; other site 1286404007157 H-loop/switch region; other site 1286404007158 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404007159 FtsX-like permease family; Region: FtsX; pfam02687 1286404007160 hypothetical protein; Provisional; Region: PRK06760 1286404007161 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 1286404007162 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1286404007163 homoserine dehydrogenase; Validated; Region: PRK06813 1286404007164 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1286404007165 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404007166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404007167 DNA-binding site [nucleotide binding]; DNA binding site 1286404007168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404007169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404007170 homodimer interface [polypeptide binding]; other site 1286404007171 catalytic residue [active] 1286404007172 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1286404007173 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1286404007174 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286404007175 Putative transcription activator [Transcription]; Region: TenA; COG0819 1286404007176 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 1286404007177 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 1286404007178 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 1286404007179 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1286404007180 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1286404007181 Int/Topo IB signature motif; other site 1286404007182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404007183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404007184 non-specific DNA binding site [nucleotide binding]; other site 1286404007185 salt bridge; other site 1286404007186 sequence-specific DNA binding site [nucleotide binding]; other site 1286404007187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404007188 non-specific DNA binding site [nucleotide binding]; other site 1286404007189 salt bridge; other site 1286404007190 sequence-specific DNA binding site [nucleotide binding]; other site 1286404007191 Helix-turn-helix domain; Region: HTH_17; pfam12728 1286404007192 Helix-turn-helix domain; Region: HTH_36; pfam13730 1286404007193 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404007194 hypothetical protein; Validated; Region: PRK08116 1286404007195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404007196 Walker A motif; other site 1286404007197 ATP binding site [chemical binding]; other site 1286404007198 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404007199 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404007200 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1286404007201 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1286404007202 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1286404007203 Septum formation initiator; Region: DivIC; cl17659 1286404007204 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 1286404007205 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1286404007206 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1286404007207 Int/Topo IB signature motif; other site 1286404007208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404007209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404007210 non-specific DNA binding site [nucleotide binding]; other site 1286404007211 salt bridge; other site 1286404007212 sequence-specific DNA binding site [nucleotide binding]; other site 1286404007213 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1286404007214 Homeodomain-like domain; Region: HTH_23; pfam13384 1286404007215 Phage terminase, small subunit; Region: Terminase_4; cl01525 1286404007216 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1286404007217 Phage portal protein; Region: Phage_portal; pfam04860 1286404007218 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1286404007219 oligomer interface [polypeptide binding]; other site 1286404007220 active site residues [active] 1286404007221 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1286404007222 Phage capsid family; Region: Phage_capsid; pfam05065 1286404007223 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1286404007224 Phage-related protein [Function unknown]; Region: COG5412 1286404007225 Phage-related protein [Function unknown]; Region: COG4722 1286404007226 Phage tail protein; Region: Sipho_tail; cl17486 1286404007227 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1286404007228 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1286404007229 vacuolar sorting protein SNF7-like; Provisional; Region: PTZ00446 1286404007230 Haemolysin XhlA; Region: XhlA; pfam10779 1286404007231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404007232 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404007233 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404007234 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404007235 amidase catalytic site [active] 1286404007236 Zn binding residues [ion binding]; other site 1286404007237 substrate binding site [chemical binding]; other site 1286404007238 Bacterial SH3 domain; Region: SH3_3; cl17532 1286404007239 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404007240 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 1286404007241 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 1286404007242 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1286404007243 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1286404007244 Protein of unknown function; Region: DUF3658; pfam12395 1286404007245 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1286404007246 Cytochrome P450; Region: p450; cl12078 1286404007247 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404007248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1286404007249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007250 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286404007251 trimer interface [polypeptide binding]; other site 1286404007252 active site 1286404007253 substrate binding site [chemical binding]; other site 1286404007254 CoA binding site [chemical binding]; other site 1286404007255 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1286404007256 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404007257 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404007258 Cytochrome P450; Region: p450; cl12078 1286404007259 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1286404007260 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1286404007261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404007262 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404007263 active site 1286404007264 motif I; other site 1286404007265 motif II; other site 1286404007266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404007267 PAS domain S-box; Region: sensory_box; TIGR00229 1286404007268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404007269 putative active site [active] 1286404007270 heme pocket [chemical binding]; other site 1286404007271 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286404007272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404007273 dimer interface [polypeptide binding]; other site 1286404007274 phosphorylation site [posttranslational modification] 1286404007275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404007276 ATP binding site [chemical binding]; other site 1286404007277 Mg2+ binding site [ion binding]; other site 1286404007278 G-X-G motif; other site 1286404007279 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404007280 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404007281 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404007282 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404007283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404007284 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286404007285 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404007286 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1286404007287 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1286404007288 active site 1286404007289 TDP-binding site; other site 1286404007290 acceptor substrate-binding pocket; other site 1286404007291 homodimer interface [polypeptide binding]; other site 1286404007292 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1286404007293 aspartate racemase; Region: asp_race; TIGR00035 1286404007294 hypothetical protein; Provisional; Region: PRK13661 1286404007295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404007296 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1286404007297 Walker A/P-loop; other site 1286404007298 ATP binding site [chemical binding]; other site 1286404007299 Q-loop/lid; other site 1286404007300 ABC transporter signature motif; other site 1286404007301 Walker B; other site 1286404007302 D-loop; other site 1286404007303 H-loop/switch region; other site 1286404007304 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1286404007305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404007306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1286404007307 Walker A/P-loop; other site 1286404007308 ATP binding site [chemical binding]; other site 1286404007309 Q-loop/lid; other site 1286404007310 ABC transporter signature motif; other site 1286404007311 Walker B; other site 1286404007312 D-loop; other site 1286404007313 H-loop/switch region; other site 1286404007314 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1286404007315 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286404007316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404007317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404007318 dimer interface [polypeptide binding]; other site 1286404007319 phosphorylation site [posttranslational modification] 1286404007320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404007321 ATP binding site [chemical binding]; other site 1286404007322 Mg2+ binding site [ion binding]; other site 1286404007323 G-X-G motif; other site 1286404007324 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1286404007325 nudix motif; other site 1286404007326 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1286404007327 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1286404007328 active site 1286404007329 ATP binding site [chemical binding]; other site 1286404007330 substrate binding site [chemical binding]; other site 1286404007331 activation loop (A-loop); other site 1286404007332 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1286404007333 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404007334 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1286404007335 NAD(P) binding site [chemical binding]; other site 1286404007336 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1286404007337 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286404007338 active site 1286404007339 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404007340 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404007341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404007342 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1286404007343 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1286404007344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404007346 putative substrate translocation pore; other site 1286404007347 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404007348 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404007349 VanZ like family; Region: VanZ; pfam04892 1286404007350 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 1286404007351 EDD domain protein, DegV family; Region: DegV; TIGR00762 1286404007352 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1286404007353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404007354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404007355 non-specific DNA binding site [nucleotide binding]; other site 1286404007356 salt bridge; other site 1286404007357 sequence-specific DNA binding site [nucleotide binding]; other site 1286404007358 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404007359 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404007360 DNA binding residues [nucleotide binding] 1286404007361 Trm112p-like protein; Region: Trm112p; pfam03966 1286404007362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007363 S-adenosylmethionine binding site [chemical binding]; other site 1286404007364 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404007365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007367 Coenzyme A binding pocket [chemical binding]; other site 1286404007368 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1286404007369 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286404007370 active site 1286404007371 catalytic site [active] 1286404007372 metal binding site [ion binding]; metal-binding site 1286404007373 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1286404007374 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404007375 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404007376 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 1286404007377 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404007378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404007379 DNA-binding site [nucleotide binding]; DNA binding site 1286404007380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404007381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404007382 homodimer interface [polypeptide binding]; other site 1286404007383 catalytic residue [active] 1286404007384 EamA-like transporter family; Region: EamA; pfam00892 1286404007385 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404007386 EamA-like transporter family; Region: EamA; pfam00892 1286404007387 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1286404007388 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1286404007389 active site 1286404007390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007391 Coenzyme A binding pocket [chemical binding]; other site 1286404007392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1286404007393 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 1286404007394 nudix motif; other site 1286404007395 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 1286404007396 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404007397 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404007398 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1286404007399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007400 putative substrate translocation pore; other site 1286404007401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404007402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007403 Coenzyme A binding pocket [chemical binding]; other site 1286404007404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286404007405 nudix motif; other site 1286404007406 DNA polymerase III subunit beta; Validated; Region: PRK06673 1286404007407 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1286404007408 putative DNA binding surface [nucleotide binding]; other site 1286404007409 dimer interface [polypeptide binding]; other site 1286404007410 beta-clamp/clamp loader binding surface; other site 1286404007411 beta-clamp/translesion DNA polymerase binding surface; other site 1286404007412 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286404007413 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1286404007414 translation initiation factor IF-2; Provisional; Region: PRK14845 1286404007415 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1286404007416 homotrimer interaction site [polypeptide binding]; other site 1286404007417 putative active site [active] 1286404007418 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1286404007419 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1286404007420 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1286404007421 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1286404007422 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286404007423 YxiJ-like protein; Region: YxiJ; pfam14176 1286404007424 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1286404007425 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1286404007426 active site 1286404007427 nucleophile elbow; other site 1286404007428 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1286404007429 pentamer interface [polypeptide binding]; other site 1286404007430 dodecaamer interface [polypeptide binding]; other site 1286404007431 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404007432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007433 Coenzyme A binding pocket [chemical binding]; other site 1286404007434 metal-dependent hydrolase; Provisional; Region: PRK13291 1286404007435 DinB superfamily; Region: DinB_2; pfam12867 1286404007436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404007437 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404007438 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1286404007439 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1286404007440 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1286404007441 GIY-YIG motif/motif A; other site 1286404007442 active site 1286404007443 catalytic site [active] 1286404007444 putative DNA binding site [nucleotide binding]; other site 1286404007445 metal binding site [ion binding]; metal-binding site 1286404007446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404007447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007448 Coenzyme A binding pocket [chemical binding]; other site 1286404007449 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1286404007450 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1286404007451 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1286404007452 active site 1286404007453 ATP binding site [chemical binding]; other site 1286404007454 substrate binding site [chemical binding]; other site 1286404007455 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1286404007456 nudix motif; other site 1286404007457 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286404007458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404007459 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1286404007460 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1286404007461 MepB protein; Region: MepB; pfam08877 1286404007462 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1286404007463 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1286404007464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404007465 motif II; other site 1286404007466 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1286404007467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404007468 active site 1286404007469 phosphorylation site [posttranslational modification] 1286404007470 intermolecular recognition site; other site 1286404007471 dimerization interface [polypeptide binding]; other site 1286404007472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404007473 DNA binding site [nucleotide binding] 1286404007474 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1286404007475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404007476 dimerization interface [polypeptide binding]; other site 1286404007477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404007478 dimer interface [polypeptide binding]; other site 1286404007479 phosphorylation site [posttranslational modification] 1286404007480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404007481 ATP binding site [chemical binding]; other site 1286404007482 Mg2+ binding site [ion binding]; other site 1286404007483 G-X-G motif; other site 1286404007484 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1286404007485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404007486 putative DNA binding site [nucleotide binding]; other site 1286404007487 putative Zn2+ binding site [ion binding]; other site 1286404007488 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404007489 DinB superfamily; Region: DinB_2; pfam12867 1286404007490 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1286404007491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404007492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404007493 Walker A/P-loop; other site 1286404007494 ATP binding site [chemical binding]; other site 1286404007495 Q-loop/lid; other site 1286404007496 ABC transporter signature motif; other site 1286404007497 Walker B; other site 1286404007498 D-loop; other site 1286404007499 H-loop/switch region; other site 1286404007500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404007501 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404007502 FtsX-like permease family; Region: FtsX; pfam02687 1286404007503 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404007504 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286404007505 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286404007506 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404007507 tyrosine decarboxylase; Region: PLN02880 1286404007508 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286404007509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404007510 catalytic residue [active] 1286404007511 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404007512 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404007513 acyl-activating enzyme (AAE) consensus motif; other site 1286404007514 AMP binding site [chemical binding]; other site 1286404007515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404007516 Condensation domain; Region: Condensation; pfam00668 1286404007517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404007518 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1286404007519 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1286404007520 acyl-activating enzyme (AAE) consensus motif; other site 1286404007521 AMP binding site [chemical binding]; other site 1286404007522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404007523 Condensation domain; Region: Condensation; pfam00668 1286404007524 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404007525 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1286404007526 putative FMN binding site [chemical binding]; other site 1286404007527 NADPH bind site [chemical binding]; other site 1286404007528 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1286404007529 carbohydrate binding site [chemical binding]; other site 1286404007530 pullulanase, type I; Region: pulA_typeI; TIGR02104 1286404007531 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1286404007532 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1286404007533 Ca binding site [ion binding]; other site 1286404007534 active site 1286404007535 catalytic site [active] 1286404007536 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404007537 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404007538 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404007539 active site 1286404007540 Zn binding site [ion binding]; other site 1286404007541 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1286404007542 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1286404007543 active site 1286404007544 metal binding site [ion binding]; metal-binding site 1286404007545 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286404007546 DinB superfamily; Region: DinB_2; pfam12867 1286404007547 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1286404007548 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 1286404007549 SecY translocase; Region: SecY; pfam00344 1286404007550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404007551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404007552 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1286404007553 hypothetical protein; Provisional; Region: PRK07236 1286404007554 FAD binding domain; Region: FAD_binding_3; pfam01494 1286404007555 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286404007556 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1286404007557 EamA-like transporter family; Region: EamA; pfam00892 1286404007558 EamA-like transporter family; Region: EamA; pfam00892 1286404007559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404007560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404007561 DNA-binding site [nucleotide binding]; DNA binding site 1286404007562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404007563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404007564 homodimer interface [polypeptide binding]; other site 1286404007565 catalytic residue [active] 1286404007566 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404007567 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1286404007568 putative NAD(P) binding site [chemical binding]; other site 1286404007569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404007570 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286404007571 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404007572 Mg binding site [ion binding]; other site 1286404007573 nucleotide binding site [chemical binding]; other site 1286404007574 putative protofilament interface [polypeptide binding]; other site 1286404007575 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1286404007576 Predicted membrane protein [Function unknown]; Region: COG4129 1286404007577 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1286404007578 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404007579 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1286404007580 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1286404007581 germination protein YpeB; Region: spore_YpeB; TIGR02889 1286404007582 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1286404007583 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286404007584 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1286404007585 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1286404007586 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404007587 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404007588 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1286404007589 arylformamidase; Region: trp_arylform; TIGR03035 1286404007590 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286404007591 kynureninase; Region: kynureninase; TIGR01814 1286404007592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404007593 catalytic residue [active] 1286404007594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404007595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404007596 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1286404007597 nudix motif; other site 1286404007598 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1286404007599 Major royal jelly protein; Region: MRJP; pfam03022 1286404007600 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 1286404007601 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1286404007602 GAF domain; Region: GAF; pfam01590 1286404007603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404007604 Walker A motif; other site 1286404007605 ATP binding site [chemical binding]; other site 1286404007606 Walker B motif; other site 1286404007607 arginine finger; other site 1286404007608 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286404007609 NIPSNAP; Region: NIPSNAP; pfam07978 1286404007610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1286404007611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007612 Coenzyme A binding pocket [chemical binding]; other site 1286404007613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286404007614 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286404007615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286404007616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007617 S-adenosylmethionine binding site [chemical binding]; other site 1286404007618 Rrf2 family protein; Region: rrf2_super; TIGR00738 1286404007619 Transcriptional regulator; Region: Rrf2; pfam02082 1286404007620 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 1286404007621 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1286404007622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404007623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404007624 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286404007625 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1286404007626 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286404007627 E3 interaction surface; other site 1286404007628 lipoyl attachment site [posttranslational modification]; other site 1286404007629 e3 binding domain; Region: E3_binding; pfam02817 1286404007630 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286404007631 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1286404007632 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1286404007633 alpha subunit interface [polypeptide binding]; other site 1286404007634 TPP binding site [chemical binding]; other site 1286404007635 heterodimer interface [polypeptide binding]; other site 1286404007636 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286404007637 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1286404007638 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1286404007639 tetramer interface [polypeptide binding]; other site 1286404007640 TPP-binding site [chemical binding]; other site 1286404007641 heterodimer interface [polypeptide binding]; other site 1286404007642 phosphorylation loop region [posttranslational modification] 1286404007643 DinB superfamily; Region: DinB_2; pfam12867 1286404007644 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1286404007645 short chain dehydrogenase; Provisional; Region: PRK06914 1286404007646 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1286404007647 NADP binding site [chemical binding]; other site 1286404007648 active site 1286404007649 steroid binding site; other site 1286404007650 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1286404007651 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1286404007652 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1286404007653 nudix motif; other site 1286404007654 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1286404007655 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1286404007656 nucleotide binding site/active site [active] 1286404007657 HIT family signature motif; other site 1286404007658 catalytic residue [active] 1286404007659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404007660 dimer interface [polypeptide binding]; other site 1286404007661 conserved gate region; other site 1286404007662 putative PBP binding loops; other site 1286404007663 ABC-ATPase subunit interface; other site 1286404007664 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1286404007665 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1286404007666 Walker A/P-loop; other site 1286404007667 ATP binding site [chemical binding]; other site 1286404007668 Q-loop/lid; other site 1286404007669 ABC transporter signature motif; other site 1286404007670 Walker B; other site 1286404007671 D-loop; other site 1286404007672 H-loop/switch region; other site 1286404007673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1286404007674 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1286404007675 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1286404007676 Clp protease; Region: CLP_protease; pfam00574 1286404007677 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1286404007678 oligomer interface [polypeptide binding]; other site 1286404007679 active site residues [active] 1286404007680 RNA polymerase factor sigma-70; Validated; Region: PRK06704 1286404007681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404007682 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1286404007683 DNA binding residues [nucleotide binding] 1286404007684 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1286404007685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286404007686 catalytic loop [active] 1286404007687 iron binding site [ion binding]; other site 1286404007688 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1286404007689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404007690 active site 1286404007691 dimer interface [polypeptide binding]; other site 1286404007692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007693 Coenzyme A binding pocket [chemical binding]; other site 1286404007694 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1286404007695 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404007696 Interdomain contacts; other site 1286404007697 Cytokine receptor motif; other site 1286404007698 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404007699 Interdomain contacts; other site 1286404007700 Cytokine receptor motif; other site 1286404007701 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1286404007702 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1286404007703 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1286404007704 active site 1286404007705 TDP-binding site; other site 1286404007706 acceptor substrate-binding pocket; other site 1286404007707 homodimer interface [polypeptide binding]; other site 1286404007708 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1286404007709 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1286404007710 topology modulation protein; Reviewed; Region: PRK08118 1286404007711 AAA domain; Region: AAA_17; pfam13207 1286404007712 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1286404007713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007714 S-adenosylmethionine binding site [chemical binding]; other site 1286404007715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1286404007716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007717 Coenzyme A binding pocket [chemical binding]; other site 1286404007718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007719 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404007720 Coenzyme A binding pocket [chemical binding]; other site 1286404007721 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286404007722 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1286404007723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007724 Coenzyme A binding pocket [chemical binding]; other site 1286404007725 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404007726 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404007727 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1286404007728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007729 Coenzyme A binding pocket [chemical binding]; other site 1286404007730 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1286404007731 Part of AAA domain; Region: AAA_19; pfam13245 1286404007732 Family description; Region: UvrD_C_2; pfam13538 1286404007733 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 1286404007734 putative transposase OrfB; Reviewed; Region: PHA02517 1286404007735 HTH-like domain; Region: HTH_21; pfam13276 1286404007736 Integrase core domain; Region: rve; pfam00665 1286404007737 Integrase core domain; Region: rve_2; pfam13333 1286404007738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404007739 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404007740 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404007741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007742 S-adenosylmethionine binding site [chemical binding]; other site 1286404007743 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1286404007744 putative active site pocket [active] 1286404007745 dimerization interface [polypeptide binding]; other site 1286404007746 putative catalytic residue [active] 1286404007747 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1286404007748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404007749 ATP binding site [chemical binding]; other site 1286404007750 putative Mg++ binding site [ion binding]; other site 1286404007751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404007752 nucleotide binding region [chemical binding]; other site 1286404007753 ATP-binding site [chemical binding]; other site 1286404007754 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1286404007755 HRDC domain; Region: HRDC; pfam00570 1286404007756 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286404007757 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286404007758 active site 1286404007759 metal binding site [ion binding]; metal-binding site 1286404007760 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1286404007761 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 1286404007762 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1286404007763 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1286404007764 active site 1286404007765 Zn binding site [ion binding]; other site 1286404007766 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1286404007767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1286404007768 DHHA2 domain; Region: DHHA2; pfam02833 1286404007769 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1286404007770 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404007771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007772 Coenzyme A binding pocket [chemical binding]; other site 1286404007773 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404007774 Zn2+ binding site [ion binding]; other site 1286404007775 Mg2+ binding site [ion binding]; other site 1286404007776 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1286404007777 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404007778 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1286404007779 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1286404007780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286404007781 NAD(P) binding site [chemical binding]; other site 1286404007782 catalytic residues [active] 1286404007783 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286404007784 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286404007785 inhibitor site; inhibition site 1286404007786 active site 1286404007787 dimer interface [polypeptide binding]; other site 1286404007788 catalytic residue [active] 1286404007789 Proline racemase; Region: Pro_racemase; pfam05544 1286404007790 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286404007791 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286404007792 Proline racemase; Region: Pro_racemase; pfam05544 1286404007793 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1286404007794 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1286404007795 PAS domain; Region: PAS_9; pfam13426 1286404007796 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1286404007797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404007798 Walker A motif; other site 1286404007799 ATP binding site [chemical binding]; other site 1286404007800 Walker B motif; other site 1286404007801 arginine finger; other site 1286404007802 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286404007803 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1286404007804 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286404007805 catalytic loop [active] 1286404007806 iron binding site [ion binding]; other site 1286404007807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1286404007808 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1286404007809 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1286404007810 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1286404007811 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404007812 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1286404007813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404007814 Zn2+ binding site [ion binding]; other site 1286404007815 Mg2+ binding site [ion binding]; other site 1286404007816 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404007817 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404007818 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1286404007819 DltD N-terminal region; Region: DltD_N; pfam04915 1286404007820 DltD central region; Region: DltD_M; pfam04918 1286404007821 DltD C-terminal region; Region: DltD_C; pfam04914 1286404007822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404007823 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404007824 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404007825 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404007826 peptide binding site [polypeptide binding]; other site 1286404007827 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404007828 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404007829 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1286404007830 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1286404007831 active site 1286404007832 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 1286404007833 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1286404007834 Septum formation initiator; Region: DivIC; pfam04977 1286404007835 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404007836 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404007837 active site 1286404007838 catalytic tetrad [active] 1286404007839 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286404007840 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1286404007841 conserved cys residue [active] 1286404007842 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1286404007843 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1286404007844 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286404007845 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404007846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007847 S-adenosylmethionine binding site [chemical binding]; other site 1286404007848 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1286404007849 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404007850 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1286404007851 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1286404007852 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286404007853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404007854 dimerization interface [polypeptide binding]; other site 1286404007855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404007856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404007857 dimer interface [polypeptide binding]; other site 1286404007858 phosphorylation site [posttranslational modification] 1286404007859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404007860 ATP binding site [chemical binding]; other site 1286404007861 Mg2+ binding site [ion binding]; other site 1286404007862 G-X-G motif; other site 1286404007863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404007864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404007865 active site 1286404007866 phosphorylation site [posttranslational modification] 1286404007867 intermolecular recognition site; other site 1286404007868 dimerization interface [polypeptide binding]; other site 1286404007869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404007870 DNA binding site [nucleotide binding] 1286404007871 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1286404007872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404007873 motif II; other site 1286404007874 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 1286404007875 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1286404007876 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404007877 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404007878 active site 1286404007879 substrate binding site [chemical binding]; other site 1286404007880 ATP binding site [chemical binding]; other site 1286404007881 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1286404007882 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1286404007883 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1286404007884 Zn binding site [ion binding]; other site 1286404007885 EDD domain protein, DegV family; Region: DegV; TIGR00762 1286404007886 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1286404007887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286404007888 Coenzyme A binding pocket [chemical binding]; other site 1286404007889 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1286404007890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404007893 putative substrate translocation pore; other site 1286404007894 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1286404007895 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1286404007896 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1286404007897 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1286404007898 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1286404007899 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1286404007900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404007902 putative substrate translocation pore; other site 1286404007903 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1286404007904 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 1286404007905 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1286404007906 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1286404007907 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1286404007908 active site 1286404007909 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1286404007910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404007911 S-adenosylmethionine binding site [chemical binding]; other site 1286404007912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404007913 putative substrate translocation pore; other site 1286404007914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404007915 aspartate aminotransferase; Provisional; Region: PRK07681 1286404007916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404007917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404007918 homodimer interface [polypeptide binding]; other site 1286404007919 catalytic residue [active] 1286404007920 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1286404007921 pantothenate kinase; Provisional; Region: PRK13317 1286404007922 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1286404007923 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1286404007924 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1286404007925 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 1286404007926 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404007927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404007928 Walker A/P-loop; other site 1286404007929 ATP binding site [chemical binding]; other site 1286404007930 Q-loop/lid; other site 1286404007931 ABC transporter signature motif; other site 1286404007932 Walker B; other site 1286404007933 D-loop; other site 1286404007934 H-loop/switch region; other site 1286404007935 Predicted transcriptional regulators [Transcription]; Region: COG1725 1286404007936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404007937 DNA-binding site [nucleotide binding]; DNA binding site 1286404007938 DinB family; Region: DinB; cl17821 1286404007939 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1286404007940 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 1286404007941 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1286404007942 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1286404007943 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1286404007944 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1286404007945 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286404007946 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286404007947 HNH endonuclease; Region: HNH_5; pfam14279 1286404007948 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1286404007949 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1286404007950 active site 1286404007951 dimer interface [polypeptide binding]; other site 1286404007952 non-prolyl cis peptide bond; other site 1286404007953 insertion regions; other site 1286404007954 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286404007955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286404007956 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1286404007957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404007958 substrate binding pocket [chemical binding]; other site 1286404007959 membrane-bound complex binding site; other site 1286404007960 hinge residues; other site 1286404007961 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286404007962 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286404007963 Walker A/P-loop; other site 1286404007964 ATP binding site [chemical binding]; other site 1286404007965 Q-loop/lid; other site 1286404007966 ABC transporter signature motif; other site 1286404007967 Walker B; other site 1286404007968 D-loop; other site 1286404007969 H-loop/switch region; other site 1286404007970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404007971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404007972 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1286404007973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404007974 binding surface 1286404007975 TPR motif; other site 1286404007976 hypothetical protein; Provisional; Region: PRK09620 1286404007977 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1286404007978 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1286404007979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1286404007980 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1286404007981 DinB superfamily; Region: DinB_2; pfam12867 1286404007982 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1286404007983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1286404007984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404007985 Coenzyme A binding pocket [chemical binding]; other site 1286404007986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404007987 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404007988 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286404007989 active site 1286404007990 NTP binding site [chemical binding]; other site 1286404007991 metal binding triad [ion binding]; metal-binding site 1286404007992 antibiotic binding site [chemical binding]; other site 1286404007993 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1286404007994 active site 1286404007995 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286404007996 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286404007997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404007998 catalytic residue [active] 1286404007999 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404008000 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404008001 active site 1286404008002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404008003 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286404008004 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1286404008005 conserved cys residue [active] 1286404008006 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404008007 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1286404008008 NodB motif; other site 1286404008009 active site 1286404008010 catalytic site [active] 1286404008011 Zn binding site [ion binding]; other site 1286404008012 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 1286404008013 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1286404008014 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286404008015 Sulfatase; Region: Sulfatase; pfam00884 1286404008016 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1286404008017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404008018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404008019 ABC transporter; Region: ABC_tran_2; pfam12848 1286404008020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404008021 MMPL family; Region: MMPL; pfam03176 1286404008022 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1286404008023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404008024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404008025 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1286404008026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008027 Coenzyme A binding pocket [chemical binding]; other site 1286404008028 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1286404008029 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1286404008030 hinge; other site 1286404008031 active site 1286404008032 prephenate dehydrogenase; Validated; Region: PRK06545 1286404008033 prephenate dehydrogenase; Validated; Region: PRK08507 1286404008034 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1286404008035 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1286404008036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404008037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404008038 homodimer interface [polypeptide binding]; other site 1286404008039 catalytic residue [active] 1286404008040 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1286404008041 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1286404008042 Tetramer interface [polypeptide binding]; other site 1286404008043 active site 1286404008044 FMN-binding site [chemical binding]; other site 1286404008045 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1286404008046 Chorismate mutase type II; Region: CM_2; cl00693 1286404008047 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1286404008048 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 1286404008049 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 1286404008050 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1286404008051 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286404008052 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404008053 catalytic triad [active] 1286404008054 conserved cis-peptide bond; other site 1286404008055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404008056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008057 Coenzyme A binding pocket [chemical binding]; other site 1286404008058 YfzA-like protein; Region: YfzA; pfam14118 1286404008059 hypothetical protein; Provisional; Region: PRK06762 1286404008060 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1286404008061 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404008062 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404008063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1286404008064 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286404008065 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404008066 Berberine and berberine like; Region: BBE; pfam08031 1286404008067 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1286404008068 malate:quinone oxidoreductase; Validated; Region: PRK05257 1286404008069 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1286404008070 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1286404008071 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1286404008072 ligand binding site [chemical binding]; other site 1286404008073 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286404008074 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286404008075 TM-ABC transporter signature motif; other site 1286404008076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286404008077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1286404008078 TM-ABC transporter signature motif; other site 1286404008079 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286404008080 ABC transporter signature motif; other site 1286404008081 Walker B; other site 1286404008082 D-loop; other site 1286404008083 H-loop/switch region; other site 1286404008084 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286404008085 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1286404008086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404008087 Walker A/P-loop; other site 1286404008088 ATP binding site [chemical binding]; other site 1286404008089 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286404008090 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286404008091 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1286404008092 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1286404008093 putative N- and C-terminal domain interface [polypeptide binding]; other site 1286404008094 putative active site [active] 1286404008095 putative MgATP binding site [chemical binding]; other site 1286404008096 catalytic site [active] 1286404008097 metal binding site [ion binding]; metal-binding site 1286404008098 putative carbohydrate binding site [chemical binding]; other site 1286404008099 Cupin domain; Region: Cupin_2; pfam07883 1286404008100 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1286404008101 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1286404008102 putative active site; other site 1286404008103 catalytic residue [active] 1286404008104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404008105 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404008106 active site 1286404008107 metal binding site [ion binding]; metal-binding site 1286404008108 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1286404008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008110 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404008111 putative substrate translocation pore; other site 1286404008112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404008113 putative DNA binding site [nucleotide binding]; other site 1286404008114 putative Zn2+ binding site [ion binding]; other site 1286404008115 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404008116 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404008117 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404008118 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1286404008119 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1286404008120 putative catalytic cysteine [active] 1286404008121 gamma-glutamyl kinase; Provisional; Region: PRK05429 1286404008122 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1286404008123 nucleotide binding site [chemical binding]; other site 1286404008124 homotetrameric interface [polypeptide binding]; other site 1286404008125 putative phosphate binding site [ion binding]; other site 1286404008126 putative allosteric binding site; other site 1286404008127 PUA domain; Region: PUA; pfam01472 1286404008128 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1286404008129 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1286404008130 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1286404008131 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1286404008132 putative metal binding site [ion binding]; other site 1286404008133 putative dimer interface [polypeptide binding]; other site 1286404008134 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286404008135 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286404008136 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286404008137 S-methylmethionine transporter; Provisional; Region: PRK11387 1286404008138 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404008139 active site 1286404008140 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404008141 active site 1286404008142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404008143 MarR family; Region: MarR_2; pfam12802 1286404008144 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1286404008145 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1286404008146 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1286404008147 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1286404008148 putative di-iron ligands [ion binding]; other site 1286404008149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1286404008150 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1286404008151 VanW like protein; Region: VanW; pfam04294 1286404008152 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1286404008153 dimer interface [polypeptide binding]; other site 1286404008154 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1286404008155 active site 1286404008156 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1286404008157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404008158 salt bridge; other site 1286404008159 non-specific DNA binding site [nucleotide binding]; other site 1286404008160 sequence-specific DNA binding site [nucleotide binding]; other site 1286404008161 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1286404008162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404008163 motif II; other site 1286404008164 uridine kinase; Provisional; Region: PRK07667 1286404008165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404008166 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404008167 Coenzyme A binding pocket [chemical binding]; other site 1286404008168 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404008169 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404008170 active site 1286404008171 metal binding site [ion binding]; metal-binding site 1286404008172 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1286404008173 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404008174 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1286404008175 MoxR-like ATPases [General function prediction only]; Region: COG0714 1286404008176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404008177 Walker A motif; other site 1286404008178 ATP binding site [chemical binding]; other site 1286404008179 Walker B motif; other site 1286404008180 arginine finger; other site 1286404008181 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1286404008182 Protein of unknown function DUF58; Region: DUF58; pfam01882 1286404008183 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 1286404008184 proline/glycine betaine transporter; Provisional; Region: PRK10642 1286404008185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008186 putative substrate translocation pore; other site 1286404008187 acetylornithine aminotransferase; Provisional; Region: PRK02627 1286404008188 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404008189 inhibitor-cofactor binding pocket; inhibition site 1286404008190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404008191 catalytic residue [active] 1286404008192 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1286404008193 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1286404008194 tetramer interface [polypeptide binding]; other site 1286404008195 heme binding pocket [chemical binding]; other site 1286404008196 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1286404008197 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1286404008198 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286404008199 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1286404008200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286404008201 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1286404008202 active site 1286404008203 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1286404008204 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008205 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008206 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1286404008207 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1286404008208 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1286404008209 dimer interface [polypeptide binding]; other site 1286404008210 FMN binding site [chemical binding]; other site 1286404008211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404008212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404008213 putative DNA binding site [nucleotide binding]; other site 1286404008214 putative Zn2+ binding site [ion binding]; other site 1286404008215 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1286404008216 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1286404008217 G1 box; other site 1286404008218 putative GEF interaction site [polypeptide binding]; other site 1286404008219 GTP/Mg2+ binding site [chemical binding]; other site 1286404008220 Switch I region; other site 1286404008221 G2 box; other site 1286404008222 G3 box; other site 1286404008223 Switch II region; other site 1286404008224 G4 box; other site 1286404008225 G5 box; other site 1286404008226 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1286404008227 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1286404008228 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1286404008229 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1286404008230 nudix motif; other site 1286404008231 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1286404008232 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1286404008233 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1286404008234 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286404008235 putative NAD(P) binding site [chemical binding]; other site 1286404008236 active site 1286404008237 transposase/IS protein; Provisional; Region: PRK09183 1286404008238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404008239 Walker A motif; other site 1286404008240 ATP binding site [chemical binding]; other site 1286404008241 Walker B motif; other site 1286404008242 arginine finger; other site 1286404008243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404008244 Integrase core domain; Region: rve; pfam00665 1286404008245 CAAX protease self-immunity; Region: Abi; pfam02517 1286404008246 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008247 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008248 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286404008249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404008250 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1286404008251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404008252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008253 Coenzyme A binding pocket [chemical binding]; other site 1286404008254 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 1286404008255 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1286404008256 nudix motif; other site 1286404008257 EamA-like transporter family; Region: EamA; pfam00892 1286404008258 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404008259 EamA-like transporter family; Region: EamA; pfam00892 1286404008260 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404008261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404008262 DNA-binding site [nucleotide binding]; DNA binding site 1286404008263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404008264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404008265 homodimer interface [polypeptide binding]; other site 1286404008266 catalytic residue [active] 1286404008267 hypothetical protein; Validated; Region: PRK00124 1286404008268 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1286404008269 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1286404008270 uridine kinase; Validated; Region: PRK06696 1286404008271 AAA domain; Region: AAA_18; pfam13238 1286404008272 active site 1286404008273 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1286404008274 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404008275 active site 1286404008276 metal binding site [ion binding]; metal-binding site 1286404008277 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404008278 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286404008279 active site 1286404008280 ATP binding site [chemical binding]; other site 1286404008281 substrate binding site [chemical binding]; other site 1286404008282 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1286404008283 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404008284 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404008285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404008286 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404008287 Coenzyme A binding pocket [chemical binding]; other site 1286404008288 lysine transporter; Provisional; Region: PRK10836 1286404008289 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1286404008290 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1286404008291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404008292 HAMP domain; Region: HAMP; pfam00672 1286404008293 dimerization interface [polypeptide binding]; other site 1286404008294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404008295 dimer interface [polypeptide binding]; other site 1286404008296 phosphorylation site [posttranslational modification] 1286404008297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404008298 ATP binding site [chemical binding]; other site 1286404008299 Mg2+ binding site [ion binding]; other site 1286404008300 G-X-G motif; other site 1286404008301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404008302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404008303 active site 1286404008304 phosphorylation site [posttranslational modification] 1286404008305 intermolecular recognition site; other site 1286404008306 dimerization interface [polypeptide binding]; other site 1286404008307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404008308 DNA binding site [nucleotide binding] 1286404008309 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404008310 FtsX-like permease family; Region: FtsX; pfam02687 1286404008311 FtsX-like permease family; Region: FtsX; pfam02687 1286404008312 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404008313 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404008314 Walker A/P-loop; other site 1286404008315 ATP binding site [chemical binding]; other site 1286404008316 Q-loop/lid; other site 1286404008317 ABC transporter signature motif; other site 1286404008318 Walker B; other site 1286404008319 D-loop; other site 1286404008320 H-loop/switch region; other site 1286404008321 hypothetical protein; Provisional; Region: PRK06760; cl11698 1286404008322 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1286404008323 S-adenosylmethionine binding site [chemical binding]; other site 1286404008324 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1286404008325 putative active site [active] 1286404008326 nucleotide binding site [chemical binding]; other site 1286404008327 nudix motif; other site 1286404008328 putative metal binding site [ion binding]; other site 1286404008329 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1286404008330 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286404008331 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404008332 Catalytic site [active] 1286404008333 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404008334 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404008335 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404008336 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404008337 NAD-dependent deacetylase; Provisional; Region: PRK00481 1286404008338 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 1286404008339 NAD+ binding site [chemical binding]; other site 1286404008340 substrate binding site [chemical binding]; other site 1286404008341 Zn binding site [ion binding]; other site 1286404008342 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1286404008343 putative substrate binding pocket [chemical binding]; other site 1286404008344 AC domain interface; other site 1286404008345 catalytic triad [active] 1286404008346 AB domain interface; other site 1286404008347 interchain disulfide; other site 1286404008348 Predicted membrane protein [Function unknown]; Region: COG3817 1286404008349 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1286404008350 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1286404008351 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1286404008352 putative active site [active] 1286404008353 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1286404008354 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1286404008355 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1286404008356 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1286404008357 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1286404008358 Bacterial transcriptional regulator; Region: IclR; pfam01614 1286404008359 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1286404008360 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286404008361 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404008362 Catalytic site [active] 1286404008363 CutC family; Region: CutC; cl01218 1286404008364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404008365 dimerization interface [polypeptide binding]; other site 1286404008366 putative DNA binding site [nucleotide binding]; other site 1286404008367 putative Zn2+ binding site [ion binding]; other site 1286404008368 DinB superfamily; Region: DinB_2; pfam12867 1286404008369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404008370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286404008371 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1286404008372 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286404008373 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286404008374 putative active site [active] 1286404008375 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404008376 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404008377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1286404008378 Nucleoside recognition; Region: Gate; pfam07670 1286404008379 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1286404008380 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404008381 putative active site [active] 1286404008382 putative substrate binding site [chemical binding]; other site 1286404008383 ATP binding site [chemical binding]; other site 1286404008384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008385 Coenzyme A binding pocket [chemical binding]; other site 1286404008386 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1286404008387 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1286404008388 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1286404008389 dinuclear metal binding motif [ion binding]; other site 1286404008390 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404008391 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404008392 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1286404008393 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1286404008394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404008395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404008396 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1286404008397 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1286404008398 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008399 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008400 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1286404008401 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1286404008402 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1286404008403 putative active site [active] 1286404008404 putative metal binding site [ion binding]; other site 1286404008405 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286404008406 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404008407 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404008408 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286404008409 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404008410 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286404008411 catalytic triad [active] 1286404008412 dimer interface [polypeptide binding]; other site 1286404008413 conserved cis-peptide bond; other site 1286404008414 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404008415 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1286404008416 catalytic triad [active] 1286404008417 dimer interface [polypeptide binding]; other site 1286404008418 conserved cis-peptide bond; other site 1286404008419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1286404008420 Amidohydrolase family; Region: Amidohydro_3; pfam07969 1286404008421 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1286404008422 active site 1286404008423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404008424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404008425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404008426 dimerization interface [polypeptide binding]; other site 1286404008427 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404008428 MarR family; Region: MarR; pfam01047 1286404008429 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1286404008430 Cl binding site [ion binding]; other site 1286404008431 oligomer interface [polypeptide binding]; other site 1286404008432 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1286404008433 plasmid segregation protein ParM; Provisional; Region: PRK13917 1286404008434 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404008435 Mg binding site [ion binding]; other site 1286404008436 nucleotide binding site [chemical binding]; other site 1286404008437 putative protofilament interface [polypeptide binding]; other site 1286404008438 Heat induced stress protein YflT; Region: YflT; pfam11181 1286404008439 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404008440 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1286404008441 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404008442 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404008443 Spore germination protein; Region: Spore_permease; cl17796 1286404008444 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404008445 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404008446 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1286404008447 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1286404008448 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1286404008449 TspO/MBR family; Region: TspO_MBR; pfam03073 1286404008450 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1286404008451 DNA photolyase; Region: DNA_photolyase; pfam00875 1286404008452 Adenoviral protein L1 52/55-kDa; Region: Adeno_52K; pfam03052 1286404008453 Carbonic anhydrase; Region: Pro_CA; pfam00484 1286404008454 zinc binding site [ion binding]; other site 1286404008455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1286404008456 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1286404008457 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1286404008458 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286404008459 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1286404008460 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404008461 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1286404008462 NodB motif; other site 1286404008463 active site 1286404008464 catalytic site [active] 1286404008465 Zn binding site [ion binding]; other site 1286404008466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404008467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008468 Coenzyme A binding pocket [chemical binding]; other site 1286404008469 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1286404008470 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286404008471 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1286404008472 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1286404008473 active site 1286404008474 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1286404008475 arsenical-resistance protein; Region: acr3; TIGR00832 1286404008476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404008477 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1286404008478 putative metal binding site [ion binding]; other site 1286404008479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404008480 dimerization interface [polypeptide binding]; other site 1286404008481 putative DNA binding site [nucleotide binding]; other site 1286404008482 putative Zn2+ binding site [ion binding]; other site 1286404008483 DinB superfamily; Region: DinB_2; pfam12867 1286404008484 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1286404008485 RibD C-terminal domain; Region: RibD_C; cl17279 1286404008486 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1286404008487 sensor protein KdpD; Provisional; Region: PRK10490 1286404008488 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1286404008489 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286404008490 putative NAD(P) binding site [chemical binding]; other site 1286404008491 active site 1286404008492 putative substrate binding site [chemical binding]; other site 1286404008493 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404008494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404008495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404008496 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 1286404008497 CAAX protease self-immunity; Region: Abi; pfam02517 1286404008498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404008499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008500 Coenzyme A binding pocket [chemical binding]; other site 1286404008501 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286404008502 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1286404008503 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1286404008504 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404008505 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404008506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008507 putative substrate translocation pore; other site 1286404008508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404008509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404008510 short chain dehydrogenase; Provisional; Region: PRK12746 1286404008511 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1286404008512 NADP binding site [chemical binding]; other site 1286404008513 homodimer interface [polypeptide binding]; other site 1286404008514 active site 1286404008515 substrate binding site [chemical binding]; other site 1286404008516 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1286404008517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404008518 putative DNA binding site [nucleotide binding]; other site 1286404008519 putative Zn2+ binding site [ion binding]; other site 1286404008520 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404008521 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1286404008522 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286404008523 metal binding site [ion binding]; metal-binding site 1286404008524 AAA domain; Region: AAA_11; pfam13086 1286404008525 Part of AAA domain; Region: AAA_19; pfam13245 1286404008526 Erp protein C-terminus; Region: Erp_C; pfam06780 1286404008527 AAA domain; Region: AAA_30; pfam13604 1286404008528 AAA domain; Region: AAA_12; pfam13087 1286404008529 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1286404008530 putative active site [active] 1286404008531 catalytic site [active] 1286404008532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404008533 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404008534 active site 1286404008535 metal binding site [ion binding]; metal-binding site 1286404008536 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1286404008537 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1286404008538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008539 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008540 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008541 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008542 putative monooxygenase; Provisional; Region: PRK11118 1286404008543 DoxX-like family; Region: DoxX_2; pfam13564 1286404008544 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286404008545 MarR family; Region: MarR_2; pfam12802 1286404008546 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1286404008547 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1286404008548 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1286404008549 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1286404008550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404008551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404008552 active site 1286404008553 phosphorylation site [posttranslational modification] 1286404008554 intermolecular recognition site; other site 1286404008555 dimerization interface [polypeptide binding]; other site 1286404008556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404008557 DNA binding site [nucleotide binding] 1286404008558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404008559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404008560 dimerization interface [polypeptide binding]; other site 1286404008561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404008562 dimer interface [polypeptide binding]; other site 1286404008563 phosphorylation site [posttranslational modification] 1286404008564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404008565 ATP binding site [chemical binding]; other site 1286404008566 G-X-G motif; other site 1286404008567 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1286404008568 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286404008569 CAAX protease self-immunity; Region: Abi; pfam02517 1286404008570 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1286404008571 Putative sensor; Region: Sensor; pfam13796 1286404008572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404008573 Histidine kinase; Region: HisKA_3; pfam07730 1286404008574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404008575 ATP binding site [chemical binding]; other site 1286404008576 Mg2+ binding site [ion binding]; other site 1286404008577 G-X-G motif; other site 1286404008578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404008579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404008580 active site 1286404008581 phosphorylation site [posttranslational modification] 1286404008582 intermolecular recognition site; other site 1286404008583 dimerization interface [polypeptide binding]; other site 1286404008584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404008585 DNA binding residues [nucleotide binding] 1286404008586 dimerization interface [polypeptide binding]; other site 1286404008587 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404008588 FtsX-like permease family; Region: FtsX; pfam02687 1286404008589 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404008590 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404008591 Walker A/P-loop; other site 1286404008592 ATP binding site [chemical binding]; other site 1286404008593 Q-loop/lid; other site 1286404008594 ABC transporter signature motif; other site 1286404008595 Walker B; other site 1286404008596 D-loop; other site 1286404008597 H-loop/switch region; other site 1286404008598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404008599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404008600 dimer interface [polypeptide binding]; other site 1286404008601 phosphorylation site [posttranslational modification] 1286404008602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404008603 ATP binding site [chemical binding]; other site 1286404008604 Mg2+ binding site [ion binding]; other site 1286404008605 G-X-G motif; other site 1286404008606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404008607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404008608 active site 1286404008609 phosphorylation site [posttranslational modification] 1286404008610 intermolecular recognition site; other site 1286404008611 dimerization interface [polypeptide binding]; other site 1286404008612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404008613 DNA binding site [nucleotide binding] 1286404008614 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1286404008615 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 1286404008616 putative metal binding site [ion binding]; other site 1286404008617 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1286404008618 Cytochrome P450; Region: p450; pfam00067 1286404008619 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1286404008620 Flavodoxin; Region: Flavodoxin_1; pfam00258 1286404008621 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1286404008622 FAD binding pocket [chemical binding]; other site 1286404008623 FAD binding motif [chemical binding]; other site 1286404008624 catalytic residues [active] 1286404008625 NAD binding pocket [chemical binding]; other site 1286404008626 phosphate binding motif [ion binding]; other site 1286404008627 beta-alpha-beta structure motif; other site 1286404008628 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286404008629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008630 putative substrate translocation pore; other site 1286404008631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008632 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1286404008633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1286404008634 D-cysteine desulfhydrase; Validated; Region: PRK03910 1286404008635 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286404008636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404008637 catalytic residue [active] 1286404008638 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1286404008639 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404008640 active site 1286404008641 metal binding site [ion binding]; metal-binding site 1286404008642 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1286404008643 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1286404008644 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1286404008645 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1286404008646 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1286404008647 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1286404008648 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1286404008649 hypothetical protein; Provisional; Region: PRK06762 1286404008650 AAA domain; Region: AAA_33; pfam13671 1286404008651 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 1286404008652 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286404008653 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404008654 Berberine and berberine like; Region: BBE; pfam08031 1286404008655 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404008656 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404008657 Walker A/P-loop; other site 1286404008658 ATP binding site [chemical binding]; other site 1286404008659 Q-loop/lid; other site 1286404008660 ABC transporter signature motif; other site 1286404008661 Walker B; other site 1286404008662 D-loop; other site 1286404008663 H-loop/switch region; other site 1286404008664 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404008665 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404008666 FtsX-like permease family; Region: FtsX; pfam02687 1286404008667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404008668 dimerization interface [polypeptide binding]; other site 1286404008669 putative DNA binding site [nucleotide binding]; other site 1286404008670 Predicted transcriptional regulator [Transcription]; Region: COG2345 1286404008671 putative Zn2+ binding site [ion binding]; other site 1286404008672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008673 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404008674 putative substrate translocation pore; other site 1286404008675 DinB superfamily; Region: DinB_2; pfam12867 1286404008676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404008677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404008678 dimerization interface [polypeptide binding]; other site 1286404008679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404008680 dimer interface [polypeptide binding]; other site 1286404008681 phosphorylation site [posttranslational modification] 1286404008682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404008683 ATP binding site [chemical binding]; other site 1286404008684 Mg2+ binding site [ion binding]; other site 1286404008685 G-X-G motif; other site 1286404008686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404008687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404008688 active site 1286404008689 phosphorylation site [posttranslational modification] 1286404008690 intermolecular recognition site; other site 1286404008691 dimerization interface [polypeptide binding]; other site 1286404008692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404008693 DNA binding site [nucleotide binding] 1286404008694 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404008695 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404008696 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404008697 2TM domain; Region: 2TM; pfam13239 1286404008698 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 1286404008699 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1286404008700 putative dimer interface [polypeptide binding]; other site 1286404008701 catalytic triad [active] 1286404008702 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1286404008703 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1286404008704 dimer interaction site [polypeptide binding]; other site 1286404008705 substrate-binding tunnel; other site 1286404008706 active site 1286404008707 catalytic site [active] 1286404008708 substrate binding site [chemical binding]; other site 1286404008709 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1286404008710 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1286404008711 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1286404008712 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1286404008713 putative ligand binding site [chemical binding]; other site 1286404008714 putative NAD binding site [chemical binding]; other site 1286404008715 putative catalytic site [active] 1286404008716 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1286404008717 L-serine binding site [chemical binding]; other site 1286404008718 ACT domain interface; other site 1286404008719 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1286404008720 homodimer interface [polypeptide binding]; other site 1286404008721 substrate-cofactor binding pocket; other site 1286404008722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404008723 catalytic residue [active] 1286404008724 Domain of unknown function (DUF378); Region: DUF378; cl00943 1286404008725 Cupin domain; Region: Cupin_2; cl17218 1286404008726 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1286404008727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404008728 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1286404008729 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1286404008730 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1286404008731 active site 1286404008732 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404008733 substrate binding site [chemical binding]; other site 1286404008734 amidase catalytic site [active] 1286404008735 Zn binding residues [ion binding]; other site 1286404008736 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404008737 S-layer homology domain; Region: SLH; pfam00395 1286404008738 S-layer homology domain; Region: SLH; pfam00395 1286404008739 S-layer homology domain; Region: SLH; pfam00395 1286404008740 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1286404008741 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1286404008742 active site 1286404008743 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1286404008744 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1286404008745 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1286404008746 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1286404008747 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1286404008748 putative active site [active] 1286404008749 putative metal binding site [ion binding]; other site 1286404008750 NETI protein; Region: NETI; pfam14044 1286404008751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404008753 putative substrate translocation pore; other site 1286404008754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404008755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404008756 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286404008757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404008758 MarR family; Region: MarR_2; pfam12802 1286404008759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404008760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008761 putative substrate translocation pore; other site 1286404008762 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008763 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008764 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404008765 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404008766 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1286404008767 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1286404008768 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1286404008769 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404008770 SWIM zinc finger; Region: SWIM; pfam04434 1286404008771 YwiC-like protein; Region: YwiC; pfam14256 1286404008772 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1286404008773 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404008774 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1286404008775 Walker A/P-loop; other site 1286404008776 ATP binding site [chemical binding]; other site 1286404008777 Q-loop/lid; other site 1286404008778 ABC transporter signature motif; other site 1286404008779 Walker B; other site 1286404008780 D-loop; other site 1286404008781 H-loop/switch region; other site 1286404008782 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404008783 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 1286404008784 Walker A/P-loop; other site 1286404008785 ATP binding site [chemical binding]; other site 1286404008786 Q-loop/lid; other site 1286404008787 ABC transporter signature motif; other site 1286404008788 Walker B; other site 1286404008789 D-loop; other site 1286404008790 H-loop/switch region; other site 1286404008791 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1286404008792 Calreticulin family; Region: Calreticulin; pfam00262 1286404008793 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1286404008794 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1286404008795 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1286404008796 Predicted membrane protein [Function unknown]; Region: COG1288 1286404008797 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1286404008798 Endonuclease I; Region: Endonuclease_1; pfam04231 1286404008799 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1286404008800 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1286404008801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404008802 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1286404008803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404008804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404008805 non-specific DNA binding site [nucleotide binding]; other site 1286404008806 salt bridge; other site 1286404008807 sequence-specific DNA binding site [nucleotide binding]; other site 1286404008808 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1286404008809 putative deacylase active site [active] 1286404008810 histidyl-tRNA synthetase; Provisional; Region: PRK12420 1286404008811 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1286404008812 dimer interface [polypeptide binding]; other site 1286404008813 motif 1; other site 1286404008814 active site 1286404008815 motif 2; other site 1286404008816 motif 3; other site 1286404008817 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1286404008818 anticodon binding site; other site 1286404008819 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404008820 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286404008821 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1286404008822 dimer interface [polypeptide binding]; other site 1286404008823 FMN binding site [chemical binding]; other site 1286404008824 pyruvate kinase; Validated; Region: PRK06739 1286404008825 active site 1286404008826 domain interfaces; other site 1286404008827 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1286404008828 classical (c) SDRs; Region: SDR_c; cd05233 1286404008829 NAD(P) binding site [chemical binding]; other site 1286404008830 active site 1286404008831 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 1286404008832 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 1286404008833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404008834 non-specific DNA binding site [nucleotide binding]; other site 1286404008835 salt bridge; other site 1286404008836 sequence-specific DNA binding site [nucleotide binding]; other site 1286404008837 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1286404008838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404008839 motif II; other site 1286404008840 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404008841 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404008842 active site 1286404008843 ATP binding site [chemical binding]; other site 1286404008844 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1286404008845 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1286404008846 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404008847 Coenzyme A binding pocket [chemical binding]; other site 1286404008848 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1286404008849 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1286404008850 nudix motif; other site 1286404008851 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1286404008852 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1286404008853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404008854 putative metal binding site [ion binding]; other site 1286404008855 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1286404008856 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1286404008857 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286404008858 Probable transposase; Region: OrfB_IS605; pfam01385 1286404008859 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404008860 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1286404008861 maltose O-acetyltransferase; Provisional; Region: PRK10092 1286404008862 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1286404008863 active site 1286404008864 substrate binding site [chemical binding]; other site 1286404008865 trimer interface [polypeptide binding]; other site 1286404008866 CoA binding site [chemical binding]; other site 1286404008867 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1286404008868 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1286404008869 active site 1286404008870 HIGH motif; other site 1286404008871 dimer interface [polypeptide binding]; other site 1286404008872 KMSKS motif; other site 1286404008873 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 1286404008874 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1286404008875 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1286404008876 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1286404008877 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286404008878 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286404008879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404008880 Coenzyme A binding pocket [chemical binding]; other site 1286404008881 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404008882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404008883 S-adenosylmethionine binding site [chemical binding]; other site 1286404008884 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1286404008885 CGNR zinc finger; Region: zf-CGNR; pfam11706 1286404008886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404008887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404008888 putative substrate translocation pore; other site 1286404008889 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 1286404008890 hypothetical protein; Provisional; Region: PRK04164 1286404008891 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404008892 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1286404008893 Domain of unknown function DUF21; Region: DUF21; pfam01595 1286404008894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1286404008895 Transporter associated domain; Region: CorC_HlyC; smart01091 1286404008896 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1286404008897 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404008898 DNA binding residues [nucleotide binding] 1286404008899 putative dimer interface [polypeptide binding]; other site 1286404008900 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1286404008901 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1286404008902 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1286404008903 substrate binding site; other site 1286404008904 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1286404008905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404008906 NAD(P) binding site [chemical binding]; other site 1286404008907 active site 1286404008908 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1286404008909 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404008910 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1286404008911 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1286404008912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404008913 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286404008914 NAD(P) binding site [chemical binding]; other site 1286404008915 active site 1286404008916 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1286404008917 Src Homology 3 domain superfamily; Region: SH3; cl17036 1286404008918 EamA-like transporter family; Region: EamA; pfam00892 1286404008919 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404008920 EamA-like transporter family; Region: EamA; pfam00892 1286404008921 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1286404008922 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1286404008923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1286404008924 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1286404008925 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1286404008926 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1286404008927 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1286404008928 N- and C-terminal domain interface [polypeptide binding]; other site 1286404008929 active site 1286404008930 catalytic site [active] 1286404008931 metal binding site [ion binding]; metal-binding site 1286404008932 carbohydrate binding site [chemical binding]; other site 1286404008933 ATP binding site [chemical binding]; other site 1286404008934 GntP family permease; Region: GntP_permease; pfam02447 1286404008935 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1286404008936 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1286404008937 active site 1286404008938 intersubunit interactions; other site 1286404008939 catalytic residue [active] 1286404008940 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1286404008941 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286404008942 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1286404008943 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286404008944 TPP-binding site [chemical binding]; other site 1286404008945 dimer interface [polypeptide binding]; other site 1286404008946 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286404008947 PYR/PP interface [polypeptide binding]; other site 1286404008948 dimer interface [polypeptide binding]; other site 1286404008949 TPP binding site [chemical binding]; other site 1286404008950 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1286404008951 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1286404008952 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1286404008953 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1286404008954 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404008955 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1286404008956 putative NAD(P) binding site [chemical binding]; other site 1286404008957 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1286404008958 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1286404008959 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1286404008960 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404008961 putative NAD(P) binding site [chemical binding]; other site 1286404008962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286404008963 classical (c) SDRs; Region: SDR_c; cd05233 1286404008964 NAD(P) binding site [chemical binding]; other site 1286404008965 active site 1286404008966 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404008967 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404008968 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404008969 active site 1286404008970 Zn binding site [ion binding]; other site 1286404008971 Viral enhancin protein; Region: Enhancin; pfam03272 1286404008972 Peptidase M60-like family; Region: M60-like; pfam13402 1286404008973 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1286404008974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404008975 dimerization interface [polypeptide binding]; other site 1286404008976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404008977 dimer interface [polypeptide binding]; other site 1286404008978 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1286404008979 putative CheW interface [polypeptide binding]; other site 1286404008980 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1286404008981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404008982 motif II; other site 1286404008983 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1286404008984 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1286404008985 catalytic motif [active] 1286404008986 Zn binding site [ion binding]; other site 1286404008987 RibD C-terminal domain; Region: RibD_C; cl17279 1286404008988 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1286404008989 dimerization interface [polypeptide binding]; other site 1286404008990 active site 1286404008991 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404008992 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286404008993 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1286404008994 dimer interface [polypeptide binding]; other site 1286404008995 FMN binding site [chemical binding]; other site 1286404008996 BNR repeat-like domain; Region: BNR_2; pfam13088 1286404008997 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404008998 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404008999 active site 1286404009000 catalytic tetrad [active] 1286404009001 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404009002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404009003 putative substrate translocation pore; other site 1286404009004 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1286404009005 active site 1 [active] 1286404009006 dimer interface [polypeptide binding]; other site 1286404009007 hexamer interface [polypeptide binding]; other site 1286404009008 active site 2 [active] 1286404009009 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1286404009010 hexamer interface [polypeptide binding]; other site 1286404009011 active site 2 [active] 1286404009012 hypothetical protein; Provisional; Region: PRK02487 1286404009013 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1286404009014 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1286404009015 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1286404009016 PhnA protein; Region: PhnA; pfam03831 1286404009017 putative transporter; Provisional; Region: PRK11660 1286404009018 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1286404009019 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1286404009020 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1286404009021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009022 dimerization interface [polypeptide binding]; other site 1286404009023 putative DNA binding site [nucleotide binding]; other site 1286404009024 putative Zn2+ binding site [ion binding]; other site 1286404009025 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1286404009026 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1286404009027 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1286404009028 IDEAL domain; Region: IDEAL; pfam08858 1286404009029 Transcriptional regulator; Region: Rrf2; pfam02082 1286404009030 Rrf2 family protein; Region: rrf2_super; TIGR00738 1286404009031 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1286404009032 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1286404009033 ArsC family; Region: ArsC; pfam03960 1286404009034 putative catalytic residues [active] 1286404009035 thiol/disulfide switch; other site 1286404009036 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404009037 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009038 dimerization interface [polypeptide binding]; other site 1286404009039 putative DNA binding site [nucleotide binding]; other site 1286404009040 putative Zn2+ binding site [ion binding]; other site 1286404009041 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286404009042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404009043 DNA-binding site [nucleotide binding]; DNA binding site 1286404009044 UTRA domain; Region: UTRA; pfam07702 1286404009045 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404009046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404009047 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404009048 putative oxidoreductase; Provisional; Region: PRK10206 1286404009049 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286404009050 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286404009051 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1286404009052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286404009053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404009054 S-adenosylmethionine binding site [chemical binding]; other site 1286404009055 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404009056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009057 dimerization interface [polypeptide binding]; other site 1286404009058 putative DNA binding site [nucleotide binding]; other site 1286404009059 putative Zn2+ binding site [ion binding]; other site 1286404009060 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404009061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009062 dimerization interface [polypeptide binding]; other site 1286404009063 putative DNA binding site [nucleotide binding]; other site 1286404009064 putative Zn2+ binding site [ion binding]; other site 1286404009065 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404009066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404009067 active site 1286404009068 catalytic tetrad [active] 1286404009069 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1286404009070 putative hydrophobic ligand binding site [chemical binding]; other site 1286404009071 protein interface [polypeptide binding]; other site 1286404009072 gate; other site 1286404009073 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1286404009074 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1286404009075 putative active site [active] 1286404009076 putative catalytic triad [active] 1286404009077 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1286404009078 catalytic triad [active] 1286404009079 oxyanion hole [active] 1286404009080 active site 1286404009081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404009082 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404009083 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1286404009084 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1286404009085 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1286404009086 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1286404009087 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1286404009088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404009089 Coenzyme A binding pocket [chemical binding]; other site 1286404009090 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1286404009091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404009092 NAD(P) binding site [chemical binding]; other site 1286404009093 active site 1286404009094 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404009095 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404009096 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1286404009097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286404009098 acyl-activating enzyme (AAE) consensus motif; other site 1286404009099 AMP binding site [chemical binding]; other site 1286404009100 active site 1286404009101 CoA binding site [chemical binding]; other site 1286404009102 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1286404009103 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404009104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009105 dimerization interface [polypeptide binding]; other site 1286404009106 putative DNA binding site [nucleotide binding]; other site 1286404009107 putative Zn2+ binding site [ion binding]; other site 1286404009108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009109 dimerization interface [polypeptide binding]; other site 1286404009110 putative DNA binding site [nucleotide binding]; other site 1286404009111 putative Zn2+ binding site [ion binding]; other site 1286404009112 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1286404009113 active site 1286404009114 Glyco_18 domain; Region: Glyco_18; smart00636 1286404009115 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1286404009116 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 1286404009117 NodB motif; other site 1286404009118 putative active site [active] 1286404009119 putative catalytic site [active] 1286404009120 putative Zn binding site [ion binding]; other site 1286404009121 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1286404009122 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1286404009123 DXD motif; other site 1286404009124 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1286404009125 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1286404009126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404009127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404009128 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1286404009129 active site 1286404009130 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1286404009131 VPS10 domain; Region: VPS10; smart00602 1286404009132 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 1286404009133 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1286404009134 HTH domain; Region: HTH_11; pfam08279 1286404009135 WYL domain; Region: WYL; pfam13280 1286404009136 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1286404009137 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1286404009138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404009139 Walker A/P-loop; other site 1286404009140 ATP binding site [chemical binding]; other site 1286404009141 Q-loop/lid; other site 1286404009142 ABC transporter signature motif; other site 1286404009143 Walker B; other site 1286404009144 D-loop; other site 1286404009145 H-loop/switch region; other site 1286404009146 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1286404009147 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404009148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404009149 hydroxylamine reductase; Provisional; Region: PRK12310 1286404009150 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286404009151 ACS interaction site; other site 1286404009152 CODH interaction site; other site 1286404009153 metal cluster binding site [ion binding]; other site 1286404009154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404009155 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1286404009156 active site 1286404009157 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1286404009158 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1286404009159 metal binding site [ion binding]; metal-binding site 1286404009160 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 1286404009161 hypothetical protein; Provisional; Region: PRK06771 1286404009162 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404009163 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404009164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1286404009165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1286404009166 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1286404009167 dimer interface [polypeptide binding]; other site 1286404009168 ligand binding site [chemical binding]; other site 1286404009169 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1286404009170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286404009171 ligand binding site [chemical binding]; other site 1286404009172 flexible hinge region; other site 1286404009173 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1286404009174 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1286404009175 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1286404009176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404009177 putative transport protein YifK; Provisional; Region: PRK10746 1286404009178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404009179 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1286404009180 putative substrate translocation pore; other site 1286404009181 Haemolysin XhlA; Region: XhlA; pfam10779 1286404009182 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1286404009183 classical (c) SDRs; Region: SDR_c; cd05233 1286404009184 NAD(P) binding site [chemical binding]; other site 1286404009185 active site 1286404009186 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1286404009187 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1286404009188 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1286404009189 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1286404009190 transmembrane helices; other site 1286404009191 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404009192 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404009193 Coenzyme A binding pocket [chemical binding]; other site 1286404009194 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1286404009195 putative ligand binding residues [chemical binding]; other site 1286404009196 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286404009197 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286404009198 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404009199 ABC-ATPase subunit interface; other site 1286404009200 dimer interface [polypeptide binding]; other site 1286404009201 putative PBP binding regions; other site 1286404009202 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404009203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404009204 ABC-ATPase subunit interface; other site 1286404009205 dimer interface [polypeptide binding]; other site 1286404009206 putative PBP binding regions; other site 1286404009207 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1286404009208 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1286404009209 DinB superfamily; Region: DinB_2; pfam12867 1286404009210 DinB family; Region: DinB; cl17821 1286404009211 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1286404009212 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1286404009213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404009214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404009215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404009216 dimerization interface [polypeptide binding]; other site 1286404009217 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404009218 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1286404009219 NADP binding site [chemical binding]; other site 1286404009220 dimer interface [polypeptide binding]; other site 1286404009221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404009222 catalytic core [active] 1286404009223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404009224 Coenzyme A binding pocket [chemical binding]; other site 1286404009225 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 1286404009226 MutS domain III; Region: MutS_III; pfam05192 1286404009227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404009228 Walker A/P-loop; other site 1286404009229 ATP binding site [chemical binding]; other site 1286404009230 Q-loop/lid; other site 1286404009231 ABC transporter signature motif; other site 1286404009232 Walker B; other site 1286404009233 D-loop; other site 1286404009234 H-loop/switch region; other site 1286404009235 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1286404009236 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1286404009237 active site 1286404009238 Na/Ca binding site [ion binding]; other site 1286404009239 catalytic site [active] 1286404009240 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1286404009241 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1286404009242 oligoendopeptidase F; Region: pepF; TIGR00181 1286404009243 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1286404009244 active site 1286404009245 Zn binding site [ion binding]; other site 1286404009246 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1286404009247 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1286404009248 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1286404009249 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404009250 DNA binding residues [nucleotide binding] 1286404009251 drug binding residues [chemical binding]; other site 1286404009252 dimer interface [polypeptide binding]; other site 1286404009253 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1286404009254 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1286404009255 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1286404009256 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1286404009257 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1286404009258 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1286404009259 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404009260 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404009261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404009262 putative substrate translocation pore; other site 1286404009263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404009264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404009265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404009266 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1286404009267 putative dimerization interface [polypeptide binding]; other site 1286404009268 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 1286404009269 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1286404009270 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286404009271 active site 1286404009272 catalytic site [active] 1286404009273 metal binding site [ion binding]; metal-binding site 1286404009274 FAD binding domain; Region: FAD_binding_3; pfam01494 1286404009275 hypothetical protein; Provisional; Region: PRK07236 1286404009276 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1286404009277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009278 dimerization interface [polypeptide binding]; other site 1286404009279 putative DNA binding site [nucleotide binding]; other site 1286404009280 putative Zn2+ binding site [ion binding]; other site 1286404009281 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1286404009282 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1286404009283 putative NAD(P) binding site [chemical binding]; other site 1286404009284 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1286404009285 hypothetical protein; Validated; Region: PRK00029 1286404009286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404009287 TPR motif; other site 1286404009288 binding surface 1286404009289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404009290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404009291 TPR motif; other site 1286404009292 binding surface 1286404009293 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1286404009294 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1286404009295 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1286404009296 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1286404009297 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404009298 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1286404009299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404009300 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404009301 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404009302 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404009303 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404009304 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1286404009305 active site 1286404009306 catalytic site [active] 1286404009307 putative metal binding site [ion binding]; other site 1286404009308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1286404009309 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1286404009310 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404009311 Interdomain contacts; other site 1286404009312 Cytokine receptor motif; other site 1286404009313 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404009314 Interdomain contacts; other site 1286404009315 Cytokine receptor motif; other site 1286404009316 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1286404009317 Fic/DOC family; Region: Fic; pfam02661 1286404009318 Fic family protein [Function unknown]; Region: COG3177 1286404009319 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404009320 Spore germination protein; Region: Spore_permease; cl17796 1286404009321 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404009322 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404009323 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 1286404009324 PKC phosphorylation site [posttranslational modification]; other site 1286404009325 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 1286404009326 Peptidase M60-like family; Region: M60-like; pfam13402 1286404009327 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1286404009328 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404009329 Interdomain contacts; other site 1286404009330 Cytokine receptor motif; other site 1286404009331 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1286404009332 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1286404009333 PAS domain S-box; Region: sensory_box; TIGR00229 1286404009334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404009335 putative active site [active] 1286404009336 heme pocket [chemical binding]; other site 1286404009337 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404009338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404009339 metal binding site [ion binding]; metal-binding site 1286404009340 active site 1286404009341 I-site; other site 1286404009342 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404009343 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404009344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404009345 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404009346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404009347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404009348 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1286404009349 S-layer homology domain; Region: SLH; pfam00395 1286404009350 S-layer homology domain; Region: SLH; pfam00395 1286404009351 S-layer homology domain; Region: SLH; pfam00395 1286404009352 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286404009353 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286404009354 active site 1286404009355 metal binding site [ion binding]; metal-binding site 1286404009356 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1286404009357 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1286404009358 TQXA domain; Region: TQXA_dom; TIGR03934 1286404009359 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404009360 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404009361 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404009362 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404009363 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1286404009364 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286404009365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404009366 dimer interface [polypeptide binding]; other site 1286404009367 phosphorylation site [posttranslational modification] 1286404009368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404009369 ATP binding site [chemical binding]; other site 1286404009370 Mg2+ binding site [ion binding]; other site 1286404009371 G-X-G motif; other site 1286404009372 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1286404009373 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1286404009374 FOG: PKD repeat [General function prediction only]; Region: COG3291 1286404009375 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1286404009376 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286404009377 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1286404009378 MgtC family; Region: MgtC; pfam02308 1286404009379 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1286404009380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404009381 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1286404009382 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1286404009383 putative metal binding site [ion binding]; other site 1286404009384 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1286404009385 active site 1286404009386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404009387 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286404009388 substrate binding pocket [chemical binding]; other site 1286404009389 membrane-bound complex binding site; other site 1286404009390 hinge residues; other site 1286404009391 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286404009392 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286404009393 Walker A/P-loop; other site 1286404009394 ATP binding site [chemical binding]; other site 1286404009395 Q-loop/lid; other site 1286404009396 ABC transporter signature motif; other site 1286404009397 Walker B; other site 1286404009398 D-loop; other site 1286404009399 H-loop/switch region; other site 1286404009400 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286404009401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404009402 dimer interface [polypeptide binding]; other site 1286404009403 conserved gate region; other site 1286404009404 putative PBP binding loops; other site 1286404009405 ABC-ATPase subunit interface; other site 1286404009406 VanW like protein; Region: VanW; pfam04294 1286404009407 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1286404009408 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1286404009409 exonuclease; Provisional; Region: PRK06722 1286404009410 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1286404009411 active site 1286404009412 catalytic site [active] 1286404009413 substrate binding site [chemical binding]; other site 1286404009414 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404009415 DNA-binding site [nucleotide binding]; DNA binding site 1286404009416 RNA-binding motif; other site 1286404009417 flavodoxin; Provisional; Region: PRK06703 1286404009418 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1286404009419 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1286404009420 nudix motif; other site 1286404009421 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 1286404009422 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1286404009423 trimer interface [polypeptide binding]; other site 1286404009424 active site 1286404009425 substrate binding site [chemical binding]; other site 1286404009426 CoA binding site [chemical binding]; other site 1286404009427 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009428 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009429 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009430 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009431 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009432 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009433 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009434 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009435 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009436 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009437 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009438 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009439 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404009440 short chain dehydrogenase; Provisional; Region: PRK06924 1286404009441 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1286404009442 NADP binding site [chemical binding]; other site 1286404009443 homodimer interface [polypeptide binding]; other site 1286404009444 active site 1286404009445 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1286404009446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404009447 argininosuccinate lyase; Provisional; Region: PRK06705 1286404009448 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1286404009449 active sites [active] 1286404009450 tetramer interface [polypeptide binding]; other site 1286404009451 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404009452 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404009453 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1286404009454 active site 1286404009455 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1286404009456 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1286404009457 Na binding site [ion binding]; other site 1286404009458 Protein of unknown function (DUF997); Region: DUF997; pfam06196 1286404009459 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1286404009460 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1286404009461 NAD(P) binding site [chemical binding]; other site 1286404009462 catalytic residues [active] 1286404009463 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1286404009464 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286404009465 NAD(P) binding site [chemical binding]; other site 1286404009466 homotetramer interface [polypeptide binding]; other site 1286404009467 homodimer interface [polypeptide binding]; other site 1286404009468 active site 1286404009469 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1286404009470 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1286404009471 Divergent PAP2 family; Region: DUF212; pfam02681 1286404009472 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1286404009473 EamA-like transporter family; Region: EamA; pfam00892 1286404009474 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1286404009475 Domain of unknown function DUF59; Region: DUF59; pfam01883 1286404009476 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1286404009477 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1286404009478 Walker A motif; other site 1286404009479 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1286404009480 MoaE interaction surface [polypeptide binding]; other site 1286404009481 MoeB interaction surface [polypeptide binding]; other site 1286404009482 thiocarboxylated glycine; other site 1286404009483 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1286404009484 MoaE homodimer interface [polypeptide binding]; other site 1286404009485 MoaD interaction [polypeptide binding]; other site 1286404009486 active site residues [active] 1286404009487 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1286404009488 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1286404009489 dimer interface [polypeptide binding]; other site 1286404009490 putative functional site; other site 1286404009491 putative MPT binding site; other site 1286404009492 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1286404009493 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286404009494 ATP binding site [chemical binding]; other site 1286404009495 substrate interface [chemical binding]; other site 1286404009496 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1286404009497 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1286404009498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404009499 FeS/SAM binding site; other site 1286404009500 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1286404009501 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1286404009502 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1286404009503 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1286404009504 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1286404009505 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1286404009506 catalytic loop [active] 1286404009507 iron binding site [ion binding]; other site 1286404009508 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1286404009509 4Fe-4S binding domain; Region: Fer4; pfam00037 1286404009510 4Fe-4S binding domain; Region: Fer4; pfam00037 1286404009511 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1286404009512 [4Fe-4S] binding site [ion binding]; other site 1286404009513 molybdopterin cofactor binding site; other site 1286404009514 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1286404009515 molybdopterin cofactor binding site; other site 1286404009516 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404009517 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1286404009518 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404009519 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404009520 amino acid transporter; Region: 2A0306; TIGR00909 1286404009521 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1286404009522 Tubulin like; Region: Tubulin_2; pfam13809 1286404009523 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1286404009524 metal ion-dependent adhesion site (MIDAS); other site 1286404009525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404009526 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404009527 active site 1286404009528 metal binding site [ion binding]; metal-binding site 1286404009529 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1286404009530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404009531 S-adenosylmethionine binding site [chemical binding]; other site 1286404009532 O-methyltransferase; Region: Methyltransf_2; pfam00891 1286404009533 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404009534 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404009535 peptide binding site [polypeptide binding]; other site 1286404009536 putative transposase OrfB; Reviewed; Region: PHA02517 1286404009537 HTH-like domain; Region: HTH_21; pfam13276 1286404009538 Integrase core domain; Region: rve; pfam00665 1286404009539 Integrase core domain; Region: rve_2; pfam13333 1286404009540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404009541 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404009542 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404009543 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404009544 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404009545 peptide binding site [polypeptide binding]; other site 1286404009546 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404009547 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404009548 peptide binding site [polypeptide binding]; other site 1286404009549 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1286404009550 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1286404009551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404009552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404009553 DNA binding residues [nucleotide binding] 1286404009554 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1286404009555 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404009556 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404009557 Walker A/P-loop; other site 1286404009558 ATP binding site [chemical binding]; other site 1286404009559 Q-loop/lid; other site 1286404009560 ABC transporter signature motif; other site 1286404009561 Walker B; other site 1286404009562 D-loop; other site 1286404009563 H-loop/switch region; other site 1286404009564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404009565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404009566 Predicted transcriptional regulator [Transcription]; Region: COG2378 1286404009567 HTH domain; Region: HTH_11; pfam08279 1286404009568 WYL domain; Region: WYL; pfam13280 1286404009569 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1286404009570 dimer interface [polypeptide binding]; other site 1286404009571 putative oxidoreductase; Provisional; Region: PRK11579 1286404009572 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286404009573 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286404009574 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1286404009575 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1286404009576 CAP-like domain; other site 1286404009577 active site 1286404009578 primary dimer interface [polypeptide binding]; other site 1286404009579 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404009580 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404009581 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404009582 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1286404009583 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1286404009584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404009585 ATP binding site [chemical binding]; other site 1286404009586 Mg2+ binding site [ion binding]; other site 1286404009587 G-X-G motif; other site 1286404009588 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1286404009589 anchoring element; other site 1286404009590 dimer interface [polypeptide binding]; other site 1286404009591 ATP binding site [chemical binding]; other site 1286404009592 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1286404009593 active site 1286404009594 putative metal-binding site [ion binding]; other site 1286404009595 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1286404009596 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1286404009597 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286404009598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286404009599 protein binding site [polypeptide binding]; other site 1286404009600 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404009601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404009602 active site 1286404009603 phosphorylation site [posttranslational modification] 1286404009604 intermolecular recognition site; other site 1286404009605 dimerization interface [polypeptide binding]; other site 1286404009606 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404009607 DNA binding site [nucleotide binding] 1286404009608 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1286404009609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404009610 FeS/SAM binding site; other site 1286404009611 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 1286404009612 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1286404009613 effector binding site; other site 1286404009614 active site 1286404009615 Zn binding site [ion binding]; other site 1286404009616 glycine loop; other site 1286404009617 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1286404009618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1286404009619 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286404009620 active site 1286404009621 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1286404009622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404009623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404009624 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1286404009625 active site 1286404009626 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1286404009627 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1286404009628 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 1286404009629 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1286404009630 active site 1286404009631 catalytic site [active] 1286404009632 substrate binding site [chemical binding]; other site 1286404009633 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1286404009634 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286404009635 catalytic residues [active] 1286404009636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404009637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404009638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404009639 Walker A/P-loop; other site 1286404009640 ATP binding site [chemical binding]; other site 1286404009641 Q-loop/lid; other site 1286404009642 ABC transporter signature motif; other site 1286404009643 Walker B; other site 1286404009644 D-loop; other site 1286404009645 H-loop/switch region; other site 1286404009646 aconitate hydratase; Validated; Region: PRK09277 1286404009647 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1286404009648 substrate binding site [chemical binding]; other site 1286404009649 ligand binding site [chemical binding]; other site 1286404009650 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1286404009651 substrate binding site [chemical binding]; other site 1286404009652 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1286404009653 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404009654 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1286404009655 NodB motif; other site 1286404009656 active site 1286404009657 catalytic site [active] 1286404009658 metal binding site [ion binding]; metal-binding site 1286404009659 Small acid-soluble spore protein P family; Region: SspP; cl12105 1286404009660 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1286404009661 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1286404009662 putative dimer interface [polypeptide binding]; other site 1286404009663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404009664 putative substrate translocation pore; other site 1286404009665 putative transporter; Provisional; Region: PRK10054 1286404009666 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1286404009667 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286404009668 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286404009669 nudix motif; other site 1286404009670 SAP domain; Region: SAP; cl02640 1286404009671 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1286404009672 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286404009673 dimer interface [polypeptide binding]; other site 1286404009674 active site 1286404009675 acyl-CoA synthetase; Validated; Region: PRK07638 1286404009676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286404009677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286404009678 acyl-activating enzyme (AAE) consensus motif; other site 1286404009679 acyl-activating enzyme (AAE) consensus motif; other site 1286404009680 AMP binding site [chemical binding]; other site 1286404009681 active site 1286404009682 CoA binding site [chemical binding]; other site 1286404009683 BioY family; Region: BioY; pfam02632 1286404009684 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1286404009685 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1286404009686 dimer interface [polypeptide binding]; other site 1286404009687 acyl-activating enzyme (AAE) consensus motif; other site 1286404009688 putative active site [active] 1286404009689 AMP binding site [chemical binding]; other site 1286404009690 putative CoA binding site [chemical binding]; other site 1286404009691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404009692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404009693 non-specific DNA binding site [nucleotide binding]; other site 1286404009694 salt bridge; other site 1286404009695 sequence-specific DNA binding site [nucleotide binding]; other site 1286404009696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404009697 Coenzyme A binding pocket [chemical binding]; other site 1286404009698 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1286404009699 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404009700 amidase catalytic site [active] 1286404009701 Zn binding residues [ion binding]; other site 1286404009702 substrate binding site [chemical binding]; other site 1286404009703 active site 1286404009704 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1286404009705 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404009706 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404009707 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404009708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404009709 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1286404009710 dimer interface [polypeptide binding]; other site 1286404009711 putative metal binding site [ion binding]; other site 1286404009712 PAS domain S-box; Region: sensory_box; TIGR00229 1286404009713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404009714 putative active site [active] 1286404009715 heme pocket [chemical binding]; other site 1286404009716 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286404009717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404009718 putative active site [active] 1286404009719 heme pocket [chemical binding]; other site 1286404009720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404009721 dimer interface [polypeptide binding]; other site 1286404009722 phosphorylation site [posttranslational modification] 1286404009723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404009724 ATP binding site [chemical binding]; other site 1286404009725 Mg2+ binding site [ion binding]; other site 1286404009726 G-X-G motif; other site 1286404009727 Predicted esterase [General function prediction only]; Region: COG0400 1286404009728 putative hydrolase; Provisional; Region: PRK11460 1286404009729 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1286404009730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404009731 Zn binding site [ion binding]; other site 1286404009732 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1286404009733 Zn binding site [ion binding]; other site 1286404009734 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1286404009735 Na binding site [ion binding]; other site 1286404009736 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1286404009737 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1286404009738 active site 1286404009739 FMN binding site [chemical binding]; other site 1286404009740 substrate binding site [chemical binding]; other site 1286404009741 3Fe-4S cluster binding site [ion binding]; other site 1286404009742 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1286404009743 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1286404009744 FMN binding site [chemical binding]; other site 1286404009745 active site 1286404009746 substrate binding site [chemical binding]; other site 1286404009747 catalytic residue [active] 1286404009748 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1286404009749 agmatinase; Region: agmatinase; TIGR01230 1286404009750 Agmatinase-like family; Region: Agmatinase-like; cd09990 1286404009751 active site 1286404009752 oligomer interface [polypeptide binding]; other site 1286404009753 Mn binding site [ion binding]; other site 1286404009754 imidazolonepropionase; Validated; Region: PRK09356 1286404009755 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1286404009756 active site 1286404009757 urocanate hydratase; Provisional; Region: PRK05414 1286404009758 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1286404009759 active sites [active] 1286404009760 tetramer interface [polypeptide binding]; other site 1286404009761 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1286404009762 hexamer interface [polypeptide binding]; other site 1286404009763 RNA binding site [nucleotide binding]; other site 1286404009764 Histidine-zinc binding site [chemical binding]; other site 1286404009765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404009766 S-adenosylmethionine binding site [chemical binding]; other site 1286404009767 DJ-1 family protein; Region: not_thiJ; TIGR01383 1286404009768 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1286404009769 conserved cys residue [active] 1286404009770 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1286404009771 AAA domain; Region: AAA_28; pfam13521 1286404009772 active site 1286404009773 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1286404009774 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1286404009775 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1286404009776 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1286404009777 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404009778 EamA-like transporter family; Region: EamA; pfam00892 1286404009779 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1286404009780 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286404009781 metal binding site [ion binding]; metal-binding site 1286404009782 dimer interface [polypeptide binding]; other site 1286404009783 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1286404009784 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1286404009785 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404009786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404009787 Walker A/P-loop; other site 1286404009788 ATP binding site [chemical binding]; other site 1286404009789 Q-loop/lid; other site 1286404009790 ABC transporter signature motif; other site 1286404009791 Walker B; other site 1286404009792 D-loop; other site 1286404009793 H-loop/switch region; other site 1286404009794 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1286404009795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404009796 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1286404009797 putative dimerization interface [polypeptide binding]; other site 1286404009798 putative substrate binding pocket [chemical binding]; other site 1286404009799 holin-like protein; Validated; Region: PRK01658 1286404009800 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1286404009801 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286404009802 nudix motif; other site 1286404009803 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 1286404009804 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404009805 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1286404009806 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1286404009807 active site 1286404009808 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404009809 Bacterial SH3 domain; Region: SH3_3; cl17532 1286404009810 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404009811 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404009812 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1286404009813 Walker A/P-loop; other site 1286404009814 ATP binding site [chemical binding]; other site 1286404009815 Q-loop/lid; other site 1286404009816 ABC transporter signature motif; other site 1286404009817 Walker B; other site 1286404009818 D-loop; other site 1286404009819 H-loop/switch region; other site 1286404009820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404009821 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1286404009822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404009823 Walker A/P-loop; other site 1286404009824 ATP binding site [chemical binding]; other site 1286404009825 Q-loop/lid; other site 1286404009826 ABC transporter signature motif; other site 1286404009827 Walker B; other site 1286404009828 D-loop; other site 1286404009829 H-loop/switch region; other site 1286404009830 hypothetical protein; Provisional; Region: PRK01844 1286404009831 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1286404009832 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1286404009833 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1286404009834 TPP-binding site [chemical binding]; other site 1286404009835 dimer interface [polypeptide binding]; other site 1286404009836 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286404009837 PYR/PP interface [polypeptide binding]; other site 1286404009838 dimer interface [polypeptide binding]; other site 1286404009839 TPP binding site [chemical binding]; other site 1286404009840 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1286404009841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404009842 dimer interface [polypeptide binding]; other site 1286404009843 conserved gate region; other site 1286404009844 ABC-ATPase subunit interface; other site 1286404009845 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1286404009846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404009847 dimer interface [polypeptide binding]; other site 1286404009848 conserved gate region; other site 1286404009849 ABC-ATPase subunit interface; other site 1286404009850 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1286404009851 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1286404009852 Walker A/P-loop; other site 1286404009853 ATP binding site [chemical binding]; other site 1286404009854 Q-loop/lid; other site 1286404009855 ABC transporter signature motif; other site 1286404009856 Walker B; other site 1286404009857 D-loop; other site 1286404009858 H-loop/switch region; other site 1286404009859 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1286404009860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404009861 membrane-bound complex binding site; other site 1286404009862 hinge residues; other site 1286404009863 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1286404009864 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1286404009865 active site 1286404009866 metal binding site [ion binding]; metal-binding site 1286404009867 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286404009868 hypothetical protein; Provisional; Region: PRK01546 1286404009869 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404009870 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286404009871 catalytic residues [active] 1286404009872 catalytic nucleophile [active] 1286404009873 LexA repressor; Validated; Region: PRK00215 1286404009874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404009875 putative DNA binding site [nucleotide binding]; other site 1286404009876 putative Zn2+ binding site [ion binding]; other site 1286404009877 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1286404009878 Catalytic site [active] 1286404009879 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1286404009880 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1286404009881 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1286404009882 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404009883 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404009884 glutamine synthetase, type I; Region: GlnA; TIGR00653 1286404009885 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1286404009886 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1286404009887 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1286404009888 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404009889 DNA binding residues [nucleotide binding] 1286404009890 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1286404009891 Aluminium resistance protein; Region: Alum_res; pfam06838 1286404009892 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1286404009893 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1286404009894 HflX GTPase family; Region: HflX; cd01878 1286404009895 G1 box; other site 1286404009896 GTP/Mg2+ binding site [chemical binding]; other site 1286404009897 Switch I region; other site 1286404009898 G2 box; other site 1286404009899 G3 box; other site 1286404009900 Switch II region; other site 1286404009901 G4 box; other site 1286404009902 G5 box; other site 1286404009903 Predicted membrane protein [Function unknown]; Region: COG2860 1286404009904 UPF0126 domain; Region: UPF0126; pfam03458 1286404009905 UPF0126 domain; Region: UPF0126; pfam03458 1286404009906 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1286404009907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404009908 Walker A motif; other site 1286404009909 ATP binding site [chemical binding]; other site 1286404009910 Walker B motif; other site 1286404009911 arginine finger; other site 1286404009912 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1286404009913 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404009914 active site 1286404009915 catalytic residues [active] 1286404009916 DNA binding site [nucleotide binding] 1286404009917 Int/Topo IB signature motif; other site 1286404009918 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1286404009919 putative transposase OrfB; Reviewed; Region: PHA02517 1286404009920 HTH-like domain; Region: HTH_21; pfam13276 1286404009921 Integrase core domain; Region: rve; pfam00665 1286404009922 Integrase core domain; Region: rve_2; pfam13333 1286404009923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404009924 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404009925 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404009926 bacterial Hfq-like; Region: Hfq; cd01716 1286404009927 hexamer interface [polypeptide binding]; other site 1286404009928 Sm1 motif; other site 1286404009929 RNA binding site [nucleotide binding]; other site 1286404009930 Sm2 motif; other site 1286404009931 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1286404009932 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1286404009933 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404009934 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404009935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1286404009936 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1286404009937 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286404009938 active site 1286404009939 phosphorylation site [posttranslational modification] 1286404009940 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1286404009941 active site 1286404009942 P-loop; other site 1286404009943 phosphorylation site [posttranslational modification] 1286404009944 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1286404009945 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1286404009946 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1286404009947 putative substrate binding site [chemical binding]; other site 1286404009948 putative ATP binding site [chemical binding]; other site 1286404009949 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1286404009950 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1286404009951 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1286404009952 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1286404009953 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1286404009954 dimer interface [polypeptide binding]; other site 1286404009955 active site 1286404009956 metal binding site [ion binding]; metal-binding site 1286404009957 Predicted membrane protein [Function unknown]; Region: COG2322 1286404009958 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1286404009959 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1286404009960 Glyco_18 domain; Region: Glyco_18; smart00636 1286404009961 putative active site [active] 1286404009962 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1286404009963 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404009964 putative active site [active] 1286404009965 putative metal binding site [ion binding]; other site 1286404009966 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1286404009967 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286404009968 IHF dimer interface [polypeptide binding]; other site 1286404009969 IHF - DNA interface [nucleotide binding]; other site 1286404009970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404009971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404009972 Coenzyme A binding pocket [chemical binding]; other site 1286404009973 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286404009974 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286404009975 metal-binding site [ion binding] 1286404009976 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286404009977 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286404009978 metal-binding site [ion binding] 1286404009979 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404009980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404009981 motif II; other site 1286404009982 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1286404009983 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1286404009984 metal-binding site [ion binding] 1286404009985 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1286404009986 putative homodimer interface [polypeptide binding]; other site 1286404009987 putative homotetramer interface [polypeptide binding]; other site 1286404009988 allosteric switch controlling residues; other site 1286404009989 putative metal binding site [ion binding]; other site 1286404009990 putative homodimer-homodimer interface [polypeptide binding]; other site 1286404009991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404009992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404009993 DNA binding residues [nucleotide binding] 1286404009994 dimerization interface [polypeptide binding]; other site 1286404009995 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404009996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404009997 S-adenosylmethionine binding site [chemical binding]; other site 1286404009998 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286404009999 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286404010000 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286404010001 Walker A/P-loop; other site 1286404010002 ATP binding site [chemical binding]; other site 1286404010003 Q-loop/lid; other site 1286404010004 ABC transporter signature motif; other site 1286404010005 Walker B; other site 1286404010006 D-loop; other site 1286404010007 H-loop/switch region; other site 1286404010008 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404010009 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404010010 ABC-ATPase subunit interface; other site 1286404010011 dimer interface [polypeptide binding]; other site 1286404010012 putative PBP binding regions; other site 1286404010013 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404010014 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404010015 ABC-ATPase subunit interface; other site 1286404010016 dimer interface [polypeptide binding]; other site 1286404010017 putative PBP binding regions; other site 1286404010018 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1286404010019 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1286404010020 putative ligand binding residues [chemical binding]; other site 1286404010021 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1286404010022 active site 1286404010023 putative catalytic site [active] 1286404010024 DNA binding site [nucleotide binding] 1286404010025 putative phosphate binding site [ion binding]; other site 1286404010026 metal binding site A [ion binding]; metal-binding site 1286404010027 AP binding site [nucleotide binding]; other site 1286404010028 metal binding site B [ion binding]; metal-binding site 1286404010029 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1286404010030 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1286404010031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404010032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404010033 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1286404010034 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1286404010035 DNA binding site [nucleotide binding] 1286404010036 active site 1286404010037 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1286404010038 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1286404010039 endonuclease III; Region: ENDO3c; smart00478 1286404010040 minor groove reading motif; other site 1286404010041 helix-hairpin-helix signature motif; other site 1286404010042 substrate binding pocket [chemical binding]; other site 1286404010043 active site 1286404010044 peptidase T; Region: peptidase-T; TIGR01882 1286404010045 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1286404010046 metal binding site [ion binding]; metal-binding site 1286404010047 dimer interface [polypeptide binding]; other site 1286404010048 Predicted membrane protein [Function unknown]; Region: COG2364 1286404010049 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404010050 hypothetical protein; Provisional; Region: PRK06764 1286404010051 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404010052 catalytic core [active] 1286404010053 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404010054 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1286404010055 PAS domain S-box; Region: sensory_box; TIGR00229 1286404010056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404010057 putative active site [active] 1286404010058 heme pocket [chemical binding]; other site 1286404010059 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404010060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404010061 metal binding site [ion binding]; metal-binding site 1286404010062 active site 1286404010063 I-site; other site 1286404010064 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404010065 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1286404010066 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1286404010067 active site 1286404010068 homodimer interface [polypeptide binding]; other site 1286404010069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404010070 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286404010071 NAD(P) binding site [chemical binding]; other site 1286404010072 active site 1286404010073 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1286404010074 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1286404010075 NAD(P) binding site [chemical binding]; other site 1286404010076 homodimer interface [polypeptide binding]; other site 1286404010077 substrate binding site [chemical binding]; other site 1286404010078 active site 1286404010079 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1286404010080 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1286404010081 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1286404010082 holin-like protein; Validated; Region: PRK01658 1286404010083 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404010084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404010085 DNA-binding site [nucleotide binding]; DNA binding site 1286404010086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404010087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404010088 homodimer interface [polypeptide binding]; other site 1286404010089 catalytic residue [active] 1286404010090 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286404010091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404010092 DNA-binding site [nucleotide binding]; DNA binding site 1286404010093 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1286404010094 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1286404010095 beta-galactosidase; Region: BGL; TIGR03356 1286404010096 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 1286404010097 active site 1286404010098 catalytic site [active] 1286404010099 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1286404010100 putative active site [active] 1286404010101 putative catalytic triad [active] 1286404010102 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286404010103 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404010104 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1286404010105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404010106 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1286404010107 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1286404010108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404010109 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286404010110 Sulfatase; Region: Sulfatase; pfam00884 1286404010111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404010112 binding surface 1286404010113 TPR motif; other site 1286404010114 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1286404010115 G1 box; other site 1286404010116 GTP/Mg2+ binding site [chemical binding]; other site 1286404010117 Switch I region; other site 1286404010118 G3 box; other site 1286404010119 Switch II region; other site 1286404010120 G4 box; other site 1286404010121 G5 box; other site 1286404010122 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1286404010123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404010124 ATP binding site [chemical binding]; other site 1286404010125 Mg2+ binding site [ion binding]; other site 1286404010126 G-X-G motif; other site 1286404010127 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1286404010128 ATP binding site [chemical binding]; other site 1286404010129 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1286404010130 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1286404010131 MutS domain I; Region: MutS_I; pfam01624 1286404010132 MutS domain II; Region: MutS_II; pfam05188 1286404010133 MutS domain III; Region: MutS_III; pfam05192 1286404010134 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1286404010135 Walker A/P-loop; other site 1286404010136 ATP binding site [chemical binding]; other site 1286404010137 Q-loop/lid; other site 1286404010138 ABC transporter signature motif; other site 1286404010139 Walker B; other site 1286404010140 D-loop; other site 1286404010141 H-loop/switch region; other site 1286404010142 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1286404010143 Predicted membrane protein [Function unknown]; Region: COG4550 1286404010144 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1286404010145 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1286404010146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404010147 FeS/SAM binding site; other site 1286404010148 TRAM domain; Region: TRAM; pfam01938 1286404010149 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1286404010150 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1286404010151 TPP-binding site [chemical binding]; other site 1286404010152 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1286404010153 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1286404010154 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1286404010155 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1286404010156 dimer interface [polypeptide binding]; other site 1286404010157 PYR/PP interface [polypeptide binding]; other site 1286404010158 TPP binding site [chemical binding]; other site 1286404010159 substrate binding site [chemical binding]; other site 1286404010160 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286404010161 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1286404010162 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1286404010163 active site 1286404010164 dimer interface [polypeptide binding]; other site 1286404010165 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1286404010166 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1286404010167 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1286404010168 putative active site [active] 1286404010169 metal binding site [ion binding]; metal-binding site 1286404010170 homodimer binding site [polypeptide binding]; other site 1286404010171 phosphodiesterase; Provisional; Region: PRK12704 1286404010172 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1286404010173 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404010174 Zn2+ binding site [ion binding]; other site 1286404010175 Mg2+ binding site [ion binding]; other site 1286404010176 recombinase A; Provisional; Region: recA; PRK09354 1286404010177 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1286404010178 hexamer interface [polypeptide binding]; other site 1286404010179 Walker A motif; other site 1286404010180 ATP binding site [chemical binding]; other site 1286404010181 Walker B motif; other site 1286404010182 competence damage-inducible protein A; Provisional; Region: PRK00549 1286404010183 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1286404010184 putative MPT binding site; other site 1286404010185 Competence-damaged protein; Region: CinA; pfam02464 1286404010186 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1286404010187 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1286404010188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404010189 non-specific DNA binding site [nucleotide binding]; other site 1286404010190 salt bridge; other site 1286404010191 sequence-specific DNA binding site [nucleotide binding]; other site 1286404010192 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1286404010193 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286404010194 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1286404010195 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1286404010196 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1286404010197 classical (c) SDRs; Region: SDR_c; cd05233 1286404010198 NAD(P) binding site [chemical binding]; other site 1286404010199 active site 1286404010200 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1286404010201 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1286404010202 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286404010203 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1286404010204 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286404010205 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286404010206 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286404010207 TM-ABC transporter signature motif; other site 1286404010208 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1286404010209 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1286404010210 TM-ABC transporter signature motif; other site 1286404010211 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1286404010212 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1286404010213 Walker A/P-loop; other site 1286404010214 ATP binding site [chemical binding]; other site 1286404010215 Q-loop/lid; other site 1286404010216 ABC transporter signature motif; other site 1286404010217 Walker B; other site 1286404010218 D-loop; other site 1286404010219 H-loop/switch region; other site 1286404010220 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1286404010221 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1286404010222 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1286404010223 ligand binding site [chemical binding]; other site 1286404010224 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286404010225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404010226 DNA-binding site [nucleotide binding]; DNA binding site 1286404010227 UTRA domain; Region: UTRA; pfam07702 1286404010228 Tetraspanin family; Region: Tetraspannin; pfam00335 1286404010229 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1286404010230 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404010231 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286404010232 YlzJ-like protein; Region: YlzJ; pfam14035 1286404010233 Clp protease; Region: CLP_protease; pfam00574 1286404010234 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1286404010235 active site 1286404010236 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1286404010237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404010238 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1286404010239 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1286404010240 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1286404010241 dimer interface [polypeptide binding]; other site 1286404010242 active site 1286404010243 catalytic residue [active] 1286404010244 aspartate kinase I; Reviewed; Region: PRK08210 1286404010245 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1286404010246 nucleotide binding site [chemical binding]; other site 1286404010247 substrate binding site [chemical binding]; other site 1286404010248 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1286404010249 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1286404010250 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1286404010251 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286404010252 Flavoprotein; Region: Flavoprotein; cl08021 1286404010253 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404010254 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1286404010255 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1286404010256 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1286404010257 active site 1286404010258 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1286404010259 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1286404010260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404010261 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404010262 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404010263 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1286404010264 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404010265 Phage tail protein; Region: Sipho_tail; pfam05709 1286404010266 Phage tail protein; Region: Sipho_tail; cl17486 1286404010267 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 1286404010268 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1286404010269 Phage-related protein [Function unknown]; Region: COG5412 1286404010270 membrane protein P6; Region: PHA01399 1286404010271 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1286404010272 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1286404010273 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1286404010274 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1286404010275 oligomer interface [polypeptide binding]; other site 1286404010276 active site residues [active] 1286404010277 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1286404010278 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1286404010279 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1286404010280 Phage terminase, small subunit; Region: Terminase_4; cl01525 1286404010281 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1286404010282 HNH endonuclease; Region: HNH; pfam01844 1286404010283 active site 1286404010284 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1286404010285 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1286404010286 active site 1286404010287 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1286404010288 Int/Topo IB signature motif; other site 1286404010289 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1286404010290 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 1286404010291 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1286404010292 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1286404010293 replicative DNA helicase; Provisional; Region: PRK06749 1286404010294 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1286404010295 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1286404010296 Walker A motif; other site 1286404010297 ATP binding site [chemical binding]; other site 1286404010298 Walker B motif; other site 1286404010299 DNA binding loops [nucleotide binding] 1286404010300 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404010301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404010302 sequence-specific DNA binding site [nucleotide binding]; other site 1286404010303 salt bridge; other site 1286404010304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404010305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404010306 non-specific DNA binding site [nucleotide binding]; other site 1286404010307 salt bridge; other site 1286404010308 sequence-specific DNA binding site [nucleotide binding]; other site 1286404010309 Domain of unknown function (DUF955); Region: DUF955; cl01076 1286404010310 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404010311 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1286404010312 catalytic residues [active] 1286404010313 catalytic nucleophile [active] 1286404010314 Recombinase; Region: Recombinase; pfam07508 1286404010315 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1286404010316 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1286404010317 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1286404010318 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1286404010319 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1286404010320 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1286404010321 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1286404010322 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1286404010323 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1286404010324 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1286404010325 NodB motif; other site 1286404010326 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1286404010327 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1286404010328 RNase E interface [polypeptide binding]; other site 1286404010329 trimer interface [polypeptide binding]; other site 1286404010330 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1286404010331 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1286404010332 RNase E interface [polypeptide binding]; other site 1286404010333 trimer interface [polypeptide binding]; other site 1286404010334 active site 1286404010335 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1286404010336 putative nucleic acid binding region [nucleotide binding]; other site 1286404010337 G-X-X-G motif; other site 1286404010338 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1286404010339 RNA binding site [nucleotide binding]; other site 1286404010340 domain interface; other site 1286404010341 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1286404010342 16S/18S rRNA binding site [nucleotide binding]; other site 1286404010343 S13e-L30e interaction site [polypeptide binding]; other site 1286404010344 25S rRNA binding site [nucleotide binding]; other site 1286404010345 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1286404010346 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1286404010347 active site 1286404010348 Riboflavin kinase; Region: Flavokinase; pfam01687 1286404010349 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1286404010350 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1286404010351 RNA binding site [nucleotide binding]; other site 1286404010352 active site 1286404010353 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1286404010354 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1286404010355 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1286404010356 translation initiation factor IF-2; Region: IF-2; TIGR00487 1286404010357 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1286404010358 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1286404010359 G1 box; other site 1286404010360 putative GEF interaction site [polypeptide binding]; other site 1286404010361 GTP/Mg2+ binding site [chemical binding]; other site 1286404010362 Switch I region; other site 1286404010363 G2 box; other site 1286404010364 G3 box; other site 1286404010365 Switch II region; other site 1286404010366 G4 box; other site 1286404010367 G5 box; other site 1286404010368 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1286404010369 Translation-initiation factor 2; Region: IF-2; pfam11987 1286404010370 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1286404010371 hypothetical protein; Provisional; Region: PRK07714 1286404010372 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1286404010373 putative RNA binding cleft [nucleotide binding]; other site 1286404010374 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1286404010375 NusA N-terminal domain; Region: NusA_N; pfam08529 1286404010376 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1286404010377 RNA binding site [nucleotide binding]; other site 1286404010378 homodimer interface [polypeptide binding]; other site 1286404010379 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1286404010380 G-X-X-G motif; other site 1286404010381 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1286404010382 G-X-X-G motif; other site 1286404010383 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1286404010384 Sm and related proteins; Region: Sm_like; cl00259 1286404010385 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1286404010386 putative oligomer interface [polypeptide binding]; other site 1286404010387 putative RNA binding site [nucleotide binding]; other site 1286404010388 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1286404010389 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1286404010390 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1286404010391 generic binding surface II; other site 1286404010392 generic binding surface I; other site 1286404010393 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1286404010394 active site 1286404010395 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1286404010396 active site 1286404010397 catalytic site [active] 1286404010398 substrate binding site [chemical binding]; other site 1286404010399 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1286404010400 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1286404010401 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1286404010402 dimer interface [polypeptide binding]; other site 1286404010403 motif 1; other site 1286404010404 active site 1286404010405 motif 2; other site 1286404010406 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1286404010407 putative deacylase active site [active] 1286404010408 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286404010409 active site 1286404010410 motif 3; other site 1286404010411 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1286404010412 anticodon binding site; other site 1286404010413 RIP metalloprotease RseP; Region: TIGR00054 1286404010414 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1286404010415 active site 1286404010416 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1286404010417 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1286404010418 protein binding site [polypeptide binding]; other site 1286404010419 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1286404010420 putative substrate binding region [chemical binding]; other site 1286404010421 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1286404010422 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1286404010423 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1286404010424 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1286404010425 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1286404010426 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1286404010427 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1286404010428 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1286404010429 catalytic residue [active] 1286404010430 putative FPP diphosphate binding site; other site 1286404010431 putative FPP binding hydrophobic cleft; other site 1286404010432 dimer interface [polypeptide binding]; other site 1286404010433 putative IPP diphosphate binding site; other site 1286404010434 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1286404010435 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1286404010436 hinge region; other site 1286404010437 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1286404010438 putative nucleotide binding site [chemical binding]; other site 1286404010439 uridine monophosphate binding site [chemical binding]; other site 1286404010440 homohexameric interface [polypeptide binding]; other site 1286404010441 elongation factor Ts; Provisional; Region: tsf; PRK09377 1286404010442 UBA/TS-N domain; Region: UBA; pfam00627 1286404010443 Elongation factor TS; Region: EF_TS; pfam00889 1286404010444 Elongation factor TS; Region: EF_TS; pfam00889 1286404010445 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1286404010446 rRNA interaction site [nucleotide binding]; other site 1286404010447 S8 interaction site; other site 1286404010448 putative laminin-1 binding site; other site 1286404010449 transcriptional repressor CodY; Validated; Region: PRK04158 1286404010450 CodY GAF-like domain; Region: CodY; pfam06018 1286404010451 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1286404010452 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1286404010453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404010454 Walker A motif; other site 1286404010455 ATP binding site [chemical binding]; other site 1286404010456 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1286404010457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286404010458 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1286404010459 active site 1286404010460 HslU subunit interaction site [polypeptide binding]; other site 1286404010461 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286404010462 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1286404010463 active site 1286404010464 Int/Topo IB signature motif; other site 1286404010465 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1286404010466 Glucose inhibited division protein A; Region: GIDA; pfam01134 1286404010467 DNA topoisomerase I; Validated; Region: PRK05582 1286404010468 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1286404010469 active site 1286404010470 interdomain interaction site; other site 1286404010471 putative metal-binding site [ion binding]; other site 1286404010472 nucleotide binding site [chemical binding]; other site 1286404010473 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286404010474 domain I; other site 1286404010475 DNA binding groove [nucleotide binding] 1286404010476 phosphate binding site [ion binding]; other site 1286404010477 domain II; other site 1286404010478 domain III; other site 1286404010479 nucleotide binding site [chemical binding]; other site 1286404010480 catalytic site [active] 1286404010481 domain IV; other site 1286404010482 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286404010483 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286404010484 DNA protecting protein DprA; Region: dprA; TIGR00732 1286404010485 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1286404010486 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1286404010487 CoA binding domain; Region: CoA_binding; smart00881 1286404010488 CoA-ligase; Region: Ligase_CoA; pfam00549 1286404010489 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1286404010490 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1286404010491 CoA-ligase; Region: Ligase_CoA; pfam00549 1286404010492 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1286404010493 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286404010494 active site 1286404010495 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1286404010496 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1286404010497 GTP/Mg2+ binding site [chemical binding]; other site 1286404010498 G4 box; other site 1286404010499 G5 box; other site 1286404010500 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1286404010501 G1 box; other site 1286404010502 G1 box; other site 1286404010503 GTP/Mg2+ binding site [chemical binding]; other site 1286404010504 Switch I region; other site 1286404010505 G2 box; other site 1286404010506 G2 box; other site 1286404010507 G3 box; other site 1286404010508 G3 box; other site 1286404010509 Switch II region; other site 1286404010510 Switch II region; other site 1286404010511 G4 box; other site 1286404010512 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1286404010513 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1286404010514 Catalytic site [active] 1286404010515 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1286404010516 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1286404010517 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1286404010518 RimM N-terminal domain; Region: RimM; pfam01782 1286404010519 PRC-barrel domain; Region: PRC; pfam05239 1286404010520 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1286404010521 KH domain; Region: KH_4; pfam13083 1286404010522 G-X-X-G motif; other site 1286404010523 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1286404010524 signal recognition particle protein; Provisional; Region: PRK10867 1286404010525 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1286404010526 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1286404010527 P loop; other site 1286404010528 GTP binding site [chemical binding]; other site 1286404010529 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1286404010530 putative DNA-binding protein; Validated; Region: PRK00118 1286404010531 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1286404010532 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1286404010533 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1286404010534 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1286404010535 P loop; other site 1286404010536 GTP binding site [chemical binding]; other site 1286404010537 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1286404010538 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1286404010539 Walker A/P-loop; other site 1286404010540 ATP binding site [chemical binding]; other site 1286404010541 Q-loop/lid; other site 1286404010542 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1286404010543 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1286404010544 ABC transporter signature motif; other site 1286404010545 Walker B; other site 1286404010546 D-loop; other site 1286404010547 H-loop/switch region; other site 1286404010548 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1286404010549 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1286404010550 dimerization interface [polypeptide binding]; other site 1286404010551 active site 1286404010552 metal binding site [ion binding]; metal-binding site 1286404010553 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1286404010554 dsRNA binding site [nucleotide binding]; other site 1286404010555 acyl carrier protein; Provisional; Region: acpP; PRK00982 1286404010556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1286404010557 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1286404010558 NAD(P) binding site [chemical binding]; other site 1286404010559 homotetramer interface [polypeptide binding]; other site 1286404010560 homodimer interface [polypeptide binding]; other site 1286404010561 active site 1286404010562 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1286404010563 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286404010564 putative phosphate acyltransferase; Provisional; Region: PRK05331 1286404010565 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1286404010566 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1286404010567 active site 2 [active] 1286404010568 active site 1 [active] 1286404010569 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1286404010570 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1286404010571 generic binding surface II; other site 1286404010572 ssDNA binding site; other site 1286404010573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404010574 ATP binding site [chemical binding]; other site 1286404010575 putative Mg++ binding site [ion binding]; other site 1286404010576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404010577 nucleotide binding region [chemical binding]; other site 1286404010578 ATP-binding site [chemical binding]; other site 1286404010579 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1286404010580 DAK2 domain; Region: Dak2; pfam02734 1286404010581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1286404010582 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1286404010583 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1286404010584 Thiamine pyrophosphokinase; Region: TPK; cd07995 1286404010585 active site 1286404010586 dimerization interface [polypeptide binding]; other site 1286404010587 thiamine binding site [chemical binding]; other site 1286404010588 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1286404010589 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1286404010590 substrate binding site [chemical binding]; other site 1286404010591 hexamer interface [polypeptide binding]; other site 1286404010592 metal binding site [ion binding]; metal-binding site 1286404010593 GTPase RsgA; Reviewed; Region: PRK00098 1286404010594 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1286404010595 RNA binding site [nucleotide binding]; other site 1286404010596 homodimer interface [polypeptide binding]; other site 1286404010597 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1286404010598 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1286404010599 GTP/Mg2+ binding site [chemical binding]; other site 1286404010600 G4 box; other site 1286404010601 G5 box; other site 1286404010602 G1 box; other site 1286404010603 Switch I region; other site 1286404010604 G2 box; other site 1286404010605 G3 box; other site 1286404010606 Switch II region; other site 1286404010607 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1286404010608 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1286404010609 active site 1286404010610 ATP binding site [chemical binding]; other site 1286404010611 substrate binding site [chemical binding]; other site 1286404010612 activation loop (A-loop); other site 1286404010613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1286404010614 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1286404010615 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1286404010616 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1286404010617 Protein phosphatase 2C; Region: PP2C; pfam00481 1286404010618 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1286404010619 active site 1286404010620 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1286404010621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404010622 FeS/SAM binding site; other site 1286404010623 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1286404010624 NusB family; Region: NusB; pfam01029 1286404010625 putative RNA binding site [nucleotide binding]; other site 1286404010626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404010627 S-adenosylmethionine binding site [chemical binding]; other site 1286404010628 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1286404010629 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1286404010630 putative active site [active] 1286404010631 substrate binding site [chemical binding]; other site 1286404010632 putative cosubstrate binding site; other site 1286404010633 catalytic site [active] 1286404010634 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1286404010635 substrate binding site [chemical binding]; other site 1286404010636 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1286404010637 active site 1286404010638 catalytic residues [active] 1286404010639 metal binding site [ion binding]; metal-binding site 1286404010640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404010641 primosomal protein N' Region: priA; TIGR00595 1286404010642 ATP binding site [chemical binding]; other site 1286404010643 putative Mg++ binding site [ion binding]; other site 1286404010644 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1286404010645 nucleotide binding region [chemical binding]; other site 1286404010646 ATP-binding site [chemical binding]; other site 1286404010647 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1286404010648 Flavoprotein; Region: Flavoprotein; pfam02441 1286404010649 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1286404010650 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1286404010651 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1286404010652 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1286404010653 catalytic site [active] 1286404010654 G-X2-G-X-G-K; other site 1286404010655 hypothetical protein; Provisional; Region: PRK04323 1286404010656 hypothetical protein; Provisional; Region: PRK11820 1286404010657 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1286404010658 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1286404010659 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1286404010660 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1286404010661 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404010662 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286404010663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404010664 motif II; other site 1286404010665 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286404010666 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1286404010667 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1286404010668 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1286404010669 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286404010670 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286404010671 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1286404010672 active site 1286404010673 DinB superfamily; Region: DinB_2; pfam12867 1286404010674 YoqO-like protein; Region: YoqO; pfam14037 1286404010675 YoqO-like protein; Region: YoqO; pfam14037 1286404010676 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1286404010677 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1286404010678 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1286404010679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404010680 motif II; other site 1286404010681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404010682 active site 1286404010683 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1286404010684 active site 1286404010685 dimer interface [polypeptide binding]; other site 1286404010686 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1286404010687 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1286404010688 heterodimer interface [polypeptide binding]; other site 1286404010689 active site 1286404010690 FMN binding site [chemical binding]; other site 1286404010691 homodimer interface [polypeptide binding]; other site 1286404010692 substrate binding site [chemical binding]; other site 1286404010693 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1286404010694 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1286404010695 FAD binding pocket [chemical binding]; other site 1286404010696 FAD binding motif [chemical binding]; other site 1286404010697 phosphate binding motif [ion binding]; other site 1286404010698 beta-alpha-beta structure motif; other site 1286404010699 NAD binding pocket [chemical binding]; other site 1286404010700 Iron coordination center [ion binding]; other site 1286404010701 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1286404010702 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286404010703 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286404010704 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1286404010705 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286404010706 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1286404010707 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1286404010708 IMP binding site; other site 1286404010709 dimer interface [polypeptide binding]; other site 1286404010710 interdomain contacts; other site 1286404010711 partial ornithine binding site; other site 1286404010712 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1286404010713 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1286404010714 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1286404010715 catalytic site [active] 1286404010716 subunit interface [polypeptide binding]; other site 1286404010717 dihydroorotase; Validated; Region: pyrC; PRK09357 1286404010718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286404010719 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1286404010720 active site 1286404010721 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1286404010722 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286404010723 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286404010724 uracil transporter; Provisional; Region: PRK10720 1286404010725 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1286404010726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404010727 active site 1286404010728 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1286404010729 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404010730 RNA binding surface [nucleotide binding]; other site 1286404010731 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1286404010732 active site 1286404010733 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1286404010734 lipoprotein signal peptidase; Provisional; Region: PRK14787 1286404010735 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1286404010736 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1286404010737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286404010738 active site 1286404010739 HIGH motif; other site 1286404010740 nucleotide binding site [chemical binding]; other site 1286404010741 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286404010742 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1286404010743 active site 1286404010744 KMSKS motif; other site 1286404010745 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1286404010746 tRNA binding surface [nucleotide binding]; other site 1286404010747 anticodon binding site; other site 1286404010748 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1286404010749 DivIVA protein; Region: DivIVA; pfam05103 1286404010750 DivIVA domain; Region: DivI1A_domain; TIGR03544 1286404010751 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1286404010752 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1286404010753 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404010754 RNA binding surface [nucleotide binding]; other site 1286404010755 YGGT family; Region: YGGT; pfam02325 1286404010756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1286404010757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1286404010758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1286404010759 catalytic residue [active] 1286404010760 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1286404010761 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1286404010762 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1286404010763 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1286404010764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404010765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404010766 DNA binding residues [nucleotide binding] 1286404010767 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1286404010768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404010769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404010770 DNA binding residues [nucleotide binding] 1286404010771 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1286404010772 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1286404010773 cell division protein FtsZ; Validated; Region: PRK09330 1286404010774 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1286404010775 nucleotide binding site [chemical binding]; other site 1286404010776 SulA interaction site; other site 1286404010777 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1286404010778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286404010779 nucleotide binding site [chemical binding]; other site 1286404010780 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1286404010781 Cell division protein FtsA; Region: FtsA; pfam14450 1286404010782 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1286404010783 Cell division protein FtsQ; Region: FtsQ; pfam03799 1286404010784 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1286404010785 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404010786 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1286404010787 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1286404010788 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1286404010789 active site 1286404010790 homodimer interface [polypeptide binding]; other site 1286404010791 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1286404010792 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1286404010793 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1286404010794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286404010795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286404010796 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1286404010797 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1286404010798 Mg++ binding site [ion binding]; other site 1286404010799 putative catalytic motif [active] 1286404010800 putative substrate binding site [chemical binding]; other site 1286404010801 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1286404010802 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286404010803 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286404010804 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286404010805 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1286404010806 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404010807 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404010808 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1286404010809 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404010810 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404010811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404010812 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1286404010813 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1286404010814 Cell division protein FtsL; Region: FtsL; cl11433 1286404010815 MraW methylase family; Region: Methyltransf_5; pfam01795 1286404010816 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1286404010817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1286404010818 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1286404010819 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1286404010820 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1286404010821 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1286404010822 hypothetical protein; Provisional; Region: PRK13688 1286404010823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404010824 Coenzyme A binding pocket [chemical binding]; other site 1286404010825 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1286404010826 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1286404010827 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1286404010828 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1286404010829 hypothetical protein; Provisional; Region: PRK13670 1286404010830 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1286404010831 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1286404010832 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1286404010833 protein binding site [polypeptide binding]; other site 1286404010834 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1286404010835 hypothetical protein; Provisional; Region: PRK10279 1286404010836 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1286404010837 active site 1286404010838 nucleophile elbow; other site 1286404010839 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1286404010840 Nucleoside recognition; Region: Gate; pfam07670 1286404010841 Nucleoside recognition; Region: Gate; pfam07670 1286404010842 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1286404010843 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1286404010844 active site 1286404010845 (T/H)XGH motif; other site 1286404010846 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1286404010847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404010848 S-adenosylmethionine binding site [chemical binding]; other site 1286404010849 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1286404010850 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1286404010851 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404010852 catalytic core [active] 1286404010853 YlbE-like protein; Region: YlbE; pfam14003 1286404010854 Putative coat protein; Region: YlbD_coat; pfam14071 1286404010855 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1286404010856 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1286404010857 YugN-like family; Region: YugN; pfam08868 1286404010858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404010859 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404010860 putative transposase OrfB; Reviewed; Region: PHA02517 1286404010861 HTH-like domain; Region: HTH_21; pfam13276 1286404010862 Integrase core domain; Region: rve; pfam00665 1286404010863 Integrase core domain; Region: rve_2; pfam13333 1286404010864 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1286404010865 active site 1286404010866 catalytic triad [active] 1286404010867 dimer interface [polypeptide binding]; other site 1286404010868 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404010869 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404010870 putative active site [active] 1286404010871 putative NTP binding site [chemical binding]; other site 1286404010872 putative nucleic acid binding site [nucleotide binding]; other site 1286404010873 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404010874 active site 1286404010875 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1286404010876 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1286404010877 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1286404010878 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1286404010879 Subunit I/III interface [polypeptide binding]; other site 1286404010880 Subunit III/IV interface [polypeptide binding]; other site 1286404010881 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1286404010882 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1286404010883 D-pathway; other site 1286404010884 Putative ubiquinol binding site [chemical binding]; other site 1286404010885 Low-spin heme (heme b) binding site [chemical binding]; other site 1286404010886 Putative water exit pathway; other site 1286404010887 Binuclear center (heme o3/CuB) [ion binding]; other site 1286404010888 K-pathway; other site 1286404010889 Putative proton exit pathway; other site 1286404010890 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1286404010891 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1286404010892 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286404010893 Cytochrome c; Region: Cytochrom_C; pfam00034 1286404010894 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1286404010895 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286404010896 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1286404010897 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1286404010898 pyruvate carboxylase; Reviewed; Region: PRK12999 1286404010899 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286404010900 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286404010901 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286404010902 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1286404010903 active site 1286404010904 catalytic residues [active] 1286404010905 metal binding site [ion binding]; metal-binding site 1286404010906 homodimer binding site [polypeptide binding]; other site 1286404010907 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286404010908 carboxyltransferase (CT) interaction site; other site 1286404010909 biotinylation site [posttranslational modification]; other site 1286404010910 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1286404010911 hypothetical protein; Provisional; Region: PRK13666 1286404010912 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1286404010913 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1286404010914 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1286404010915 putative active site [active] 1286404010916 PhoH-like protein; Region: PhoH; pfam02562 1286404010917 hypothetical protein; Provisional; Region: PRK06733 1286404010918 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1286404010919 YlaH-like protein; Region: YlaH; pfam14036 1286404010920 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1286404010921 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1286404010922 G1 box; other site 1286404010923 putative GEF interaction site [polypeptide binding]; other site 1286404010924 GTP/Mg2+ binding site [chemical binding]; other site 1286404010925 Switch I region; other site 1286404010926 G2 box; other site 1286404010927 G3 box; other site 1286404010928 Switch II region; other site 1286404010929 G4 box; other site 1286404010930 G5 box; other site 1286404010931 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1286404010932 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1286404010933 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1286404010934 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1286404010935 active site 1286404010936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1286404010937 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1286404010938 hypothetical protein; Provisional; Region: PRK04387 1286404010939 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1286404010940 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1286404010941 homodimer interface [polypeptide binding]; other site 1286404010942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404010943 catalytic residue [active] 1286404010944 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1286404010945 transglutaminase; Provisional; Region: tgl; PRK03187 1286404010946 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1286404010947 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1286404010948 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1286404010949 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1286404010950 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 1286404010951 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1286404010952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404010953 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286404010954 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1286404010955 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286404010956 E3 interaction surface; other site 1286404010957 lipoyl attachment site [posttranslational modification]; other site 1286404010958 e3 binding domain; Region: E3_binding; pfam02817 1286404010959 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286404010960 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1286404010961 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1286404010962 alpha subunit interface [polypeptide binding]; other site 1286404010963 TPP binding site [chemical binding]; other site 1286404010964 heterodimer interface [polypeptide binding]; other site 1286404010965 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286404010966 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1286404010967 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1286404010968 TPP-binding site [chemical binding]; other site 1286404010969 heterodimer interface [polypeptide binding]; other site 1286404010970 tetramer interface [polypeptide binding]; other site 1286404010971 phosphorylation loop region [posttranslational modification] 1286404010972 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1286404010973 active site 1286404010974 catalytic residues [active] 1286404010975 metal binding site [ion binding]; metal-binding site 1286404010976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404010977 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404010978 active site 1286404010979 motif I; other site 1286404010980 motif II; other site 1286404010981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404010982 hypothetical protein; Provisional; Region: PRK13667 1286404010983 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1286404010984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404010985 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1286404010986 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1286404010987 TrkA-N domain; Region: TrkA_N; pfam02254 1286404010988 TrkA-C domain; Region: TrkA_C; pfam02080 1286404010989 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1286404010990 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1286404010991 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1286404010992 metal binding site [ion binding]; metal-binding site 1286404010993 putative dimer interface [polypeptide binding]; other site 1286404010994 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1286404010995 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1286404010996 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1286404010997 trimer interface [polypeptide binding]; other site 1286404010998 active site 1286404010999 substrate binding site [chemical binding]; other site 1286404011000 CoA binding site [chemical binding]; other site 1286404011001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404011002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404011003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404011004 dimerization interface [polypeptide binding]; other site 1286404011005 FOG: CBS domain [General function prediction only]; Region: COG0517 1286404011006 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1286404011007 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1286404011008 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1286404011009 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1286404011010 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1286404011011 catalytic residues [active] 1286404011012 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 1286404011013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404011014 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1286404011015 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1286404011016 short chain dehydrogenase; Provisional; Region: PRK07677 1286404011017 NAD(P) binding site [chemical binding]; other site 1286404011018 substrate binding site [chemical binding]; other site 1286404011019 homotetramer interface [polypeptide binding]; other site 1286404011020 active site 1286404011021 homodimer interface [polypeptide binding]; other site 1286404011022 phosphodiesterase YaeI; Provisional; Region: PRK11340 1286404011023 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1286404011024 putative active site [active] 1286404011025 putative metal binding site [ion binding]; other site 1286404011026 polyphosphate kinase; Provisional; Region: PRK05443 1286404011027 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1286404011028 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1286404011029 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1286404011030 putative domain interface [polypeptide binding]; other site 1286404011031 putative active site [active] 1286404011032 catalytic site [active] 1286404011033 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1286404011034 putative domain interface [polypeptide binding]; other site 1286404011035 putative active site [active] 1286404011036 catalytic site [active] 1286404011037 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1286404011038 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1286404011039 YkyB-like protein; Region: YkyB; pfam14177 1286404011040 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1286404011041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404011042 I-site; other site 1286404011043 active site 1286404011044 metal binding site [ion binding]; metal-binding site 1286404011045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404011046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404011047 putative substrate translocation pore; other site 1286404011048 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404011049 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1286404011050 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1286404011051 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1286404011052 THF binding site; other site 1286404011053 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1286404011054 substrate binding site [chemical binding]; other site 1286404011055 THF binding site; other site 1286404011056 zinc-binding site [ion binding]; other site 1286404011057 Competence protein J (ComJ); Region: ComJ; pfam11033 1286404011058 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1286404011059 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 1286404011060 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1286404011061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404011062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404011063 dimer interface [polypeptide binding]; other site 1286404011064 phosphorylation site [posttranslational modification] 1286404011065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404011066 ATP binding site [chemical binding]; other site 1286404011067 Mg2+ binding site [ion binding]; other site 1286404011068 G-X-G motif; other site 1286404011069 aminotransferase A; Validated; Region: PRK07683 1286404011070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404011071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011072 homodimer interface [polypeptide binding]; other site 1286404011073 catalytic residue [active] 1286404011074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404011075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404011076 DNA binding site [nucleotide binding] 1286404011077 domain linker motif; other site 1286404011078 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1286404011079 putative dimerization interface [polypeptide binding]; other site 1286404011080 putative ligand binding site [chemical binding]; other site 1286404011081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1286404011082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404011083 dimer interface [polypeptide binding]; other site 1286404011084 conserved gate region; other site 1286404011085 putative PBP binding loops; other site 1286404011086 ABC-ATPase subunit interface; other site 1286404011087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404011088 dimer interface [polypeptide binding]; other site 1286404011089 conserved gate region; other site 1286404011090 putative PBP binding loops; other site 1286404011091 ABC-ATPase subunit interface; other site 1286404011092 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1286404011093 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1286404011094 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1286404011095 homodimer interface [polypeptide binding]; other site 1286404011096 maltodextrin glucosidase; Provisional; Region: PRK10785 1286404011097 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1286404011098 active site 1286404011099 homodimer interface [polypeptide binding]; other site 1286404011100 catalytic site [active] 1286404011101 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1286404011102 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1286404011103 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1286404011104 Ca binding site [ion binding]; other site 1286404011105 active site 1286404011106 catalytic site [active] 1286404011107 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1286404011108 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1286404011109 Walker A/P-loop; other site 1286404011110 ATP binding site [chemical binding]; other site 1286404011111 Q-loop/lid; other site 1286404011112 ABC transporter signature motif; other site 1286404011113 Walker B; other site 1286404011114 D-loop; other site 1286404011115 H-loop/switch region; other site 1286404011116 TOBE domain; Region: TOBE_2; pfam08402 1286404011117 hypothetical protein; Provisional; Region: PRK06720 1286404011118 NAD(P) binding site [chemical binding]; other site 1286404011119 RDD family; Region: RDD; pfam06271 1286404011120 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 1286404011121 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1286404011122 Predicted ATPase [General function prediction only]; Region: COG3910 1286404011123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404011124 Walker A/P-loop; other site 1286404011125 ATP binding site [chemical binding]; other site 1286404011126 Q-loop/lid; other site 1286404011127 ABC transporter signature motif; other site 1286404011128 Walker B; other site 1286404011129 D-loop; other site 1286404011130 H-loop/switch region; other site 1286404011131 putative acyltransferase; Provisional; Region: PRK05790 1286404011132 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286404011133 dimer interface [polypeptide binding]; other site 1286404011134 active site 1286404011135 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1286404011136 nudix motif; other site 1286404011137 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 1286404011138 hypothetical protein; Validated; Region: PRK07668 1286404011139 hypothetical protein; Validated; Region: PRK07668 1286404011140 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404011141 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404011142 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1286404011143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404011144 NAD(P) binding site [chemical binding]; other site 1286404011145 active site 1286404011146 YvrJ protein family; Region: YvrJ; pfam12841 1286404011147 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1286404011148 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1286404011149 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1286404011150 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404011151 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1286404011152 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1286404011153 putative active site [active] 1286404011154 catalytic triad [active] 1286404011155 putative dimer interface [polypeptide binding]; other site 1286404011156 transaminase; Reviewed; Region: PRK08068 1286404011157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404011158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011159 homodimer interface [polypeptide binding]; other site 1286404011160 catalytic residue [active] 1286404011161 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1286404011162 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1286404011163 dimer interface [polypeptide binding]; other site 1286404011164 active site 1286404011165 catalytic residue [active] 1286404011166 metal binding site [ion binding]; metal-binding site 1286404011167 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 1286404011168 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1286404011169 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1286404011170 intersubunit interface [polypeptide binding]; other site 1286404011171 active site 1286404011172 Zn2+ binding site [ion binding]; other site 1286404011173 ARD/ARD' family; Region: ARD; pfam03079 1286404011174 Cupin domain; Region: Cupin_2; pfam07883 1286404011175 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 1286404011176 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1286404011177 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1286404011178 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404011179 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404011180 PAS domain; Region: PAS_8; pfam13188 1286404011181 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404011182 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404011183 metal binding site [ion binding]; metal-binding site 1286404011184 active site 1286404011185 I-site; other site 1286404011186 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1286404011187 dimer interface [polypeptide binding]; other site 1286404011188 FMN binding site [chemical binding]; other site 1286404011189 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 1286404011190 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1286404011191 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1286404011192 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1286404011193 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1286404011194 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286404011195 dimerization domain swap beta strand [polypeptide binding]; other site 1286404011196 regulatory protein interface [polypeptide binding]; other site 1286404011197 active site 1286404011198 regulatory phosphorylation site [posttranslational modification]; other site 1286404011199 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1286404011200 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1286404011201 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1286404011202 active site turn [active] 1286404011203 phosphorylation site [posttranslational modification] 1286404011204 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1286404011205 HPr interaction site; other site 1286404011206 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1286404011207 active site 1286404011208 phosphorylation site [posttranslational modification] 1286404011209 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1286404011210 CAT RNA binding domain; Region: CAT_RBD; smart01061 1286404011211 PRD domain; Region: PRD; pfam00874 1286404011212 PRD domain; Region: PRD; pfam00874 1286404011213 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404011214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404011215 active site 1286404011216 motif I; other site 1286404011217 motif II; other site 1286404011218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404011219 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286404011220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404011221 DNA-binding site [nucleotide binding]; DNA binding site 1286404011222 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1286404011223 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1286404011224 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1286404011225 active site 1286404011226 trimer interface [polypeptide binding]; other site 1286404011227 allosteric site; other site 1286404011228 active site lid [active] 1286404011229 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1286404011230 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1286404011231 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1286404011232 active site 1286404011233 dimer interface [polypeptide binding]; other site 1286404011234 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1286404011235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404011236 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1286404011237 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1286404011238 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1286404011239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404011240 Coenzyme A binding pocket [chemical binding]; other site 1286404011241 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1286404011242 active site 1286404011243 Predicted secreted protein [Function unknown]; Region: COG4086 1286404011244 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1286404011245 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404011246 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1286404011247 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286404011248 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404011249 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1286404011250 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1286404011251 stage V sporulation protein AD; Validated; Region: PRK08304 1286404011252 stage V sporulation protein AD; Provisional; Region: PRK12404 1286404011253 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1286404011254 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1286404011255 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1286404011256 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1286404011257 Na2 binding site [ion binding]; other site 1286404011258 putative substrate binding site 1 [chemical binding]; other site 1286404011259 Na binding site 1 [ion binding]; other site 1286404011260 putative substrate binding site 2 [chemical binding]; other site 1286404011261 sporulation sigma factor SigF; Validated; Region: PRK05572 1286404011262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404011263 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1286404011264 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404011265 DNA binding residues [nucleotide binding] 1286404011266 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1286404011267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404011268 ATP binding site [chemical binding]; other site 1286404011269 Mg2+ binding site [ion binding]; other site 1286404011270 G-X-G motif; other site 1286404011271 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1286404011272 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1286404011273 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404011274 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1286404011275 Predicted transcriptional regulators [Transcription]; Region: COG1725 1286404011276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404011277 DNA-binding site [nucleotide binding]; DNA binding site 1286404011278 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404011279 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404011280 Walker A/P-loop; other site 1286404011281 ATP binding site [chemical binding]; other site 1286404011282 Q-loop/lid; other site 1286404011283 ABC transporter signature motif; other site 1286404011284 Walker B; other site 1286404011285 D-loop; other site 1286404011286 H-loop/switch region; other site 1286404011287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404011288 MarR family; Region: MarR; pfam01047 1286404011289 MarR family; Region: MarR_2; cl17246 1286404011290 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1286404011291 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1286404011292 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1286404011293 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1286404011294 oligomer interface [polypeptide binding]; other site 1286404011295 metal binding site [ion binding]; metal-binding site 1286404011296 metal binding site [ion binding]; metal-binding site 1286404011297 putative Cl binding site [ion binding]; other site 1286404011298 aspartate ring; other site 1286404011299 basic sphincter; other site 1286404011300 hydrophobic gate; other site 1286404011301 periplasmic entrance; other site 1286404011302 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1286404011303 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1286404011304 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1286404011305 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1286404011306 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1286404011307 phosphopentomutase; Provisional; Region: PRK05362 1286404011308 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1286404011309 YtkA-like; Region: YtkA; pfam13115 1286404011310 YtkA-like; Region: YtkA; pfam13115 1286404011311 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1286404011312 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404011313 active site 1286404011314 Int/Topo IB signature motif; other site 1286404011315 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1286404011316 ferric uptake regulator; Provisional; Region: fur; PRK09462 1286404011317 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286404011318 metal binding site 2 [ion binding]; metal-binding site 1286404011319 putative DNA binding helix; other site 1286404011320 metal binding site 1 [ion binding]; metal-binding site 1286404011321 dimer interface [polypeptide binding]; other site 1286404011322 structural Zn2+ binding site [ion binding]; other site 1286404011323 Integral membrane protein DUF95; Region: DUF95; cl00572 1286404011324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404011325 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404011326 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1286404011327 dimer interface [polypeptide binding]; other site 1286404011328 ADP-ribose binding site [chemical binding]; other site 1286404011329 active site 1286404011330 nudix motif; other site 1286404011331 metal binding site [ion binding]; metal-binding site 1286404011332 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1286404011333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404011334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404011335 active site 1286404011336 catalytic tetrad [active] 1286404011337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404011338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404011339 active site 1286404011340 catalytic tetrad [active] 1286404011341 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1286404011342 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 1286404011343 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1286404011344 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1286404011345 putative active site [active] 1286404011346 putative metal binding site [ion binding]; other site 1286404011347 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286404011348 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1286404011349 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404011350 Predicted permease [General function prediction only]; Region: COG2056 1286404011351 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1286404011352 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1286404011353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404011354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404011355 DNA binding site [nucleotide binding] 1286404011356 domain linker motif; other site 1286404011357 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1286404011358 dimerization interface [polypeptide binding]; other site 1286404011359 ligand binding site [chemical binding]; other site 1286404011360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404011361 Coenzyme A binding pocket [chemical binding]; other site 1286404011362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404011363 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1286404011364 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1286404011365 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1286404011366 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1286404011367 catalytic motif [active] 1286404011368 Zn binding site [ion binding]; other site 1286404011369 RibD C-terminal domain; Region: RibD_C; cl17279 1286404011370 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1286404011371 Lumazine binding domain; Region: Lum_binding; pfam00677 1286404011372 Lumazine binding domain; Region: Lum_binding; pfam00677 1286404011373 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1286404011374 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1286404011375 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1286404011376 dimerization interface [polypeptide binding]; other site 1286404011377 active site 1286404011378 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1286404011379 homopentamer interface [polypeptide binding]; other site 1286404011380 active site 1286404011381 biotin synthase; Validated; Region: PRK06256 1286404011382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404011383 FeS/SAM binding site; other site 1286404011384 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1286404011385 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1286404011386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404011387 S-adenosylmethionine binding site [chemical binding]; other site 1286404011388 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404011389 Protein of unknown function (DUF452); Region: DUF452; cl01062 1286404011390 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286404011391 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1286404011392 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1286404011393 substrate-cofactor binding pocket; other site 1286404011394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011395 catalytic residue [active] 1286404011396 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1286404011397 AAA domain; Region: AAA_26; pfam13500 1286404011398 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1286404011399 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404011400 inhibitor-cofactor binding pocket; inhibition site 1286404011401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011402 catalytic residue [active] 1286404011403 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286404011404 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1286404011405 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 1286404011406 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1286404011407 active site 1286404011408 metal binding site [ion binding]; metal-binding site 1286404011409 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286404011410 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1286404011411 active site 1286404011412 catalytic triad [active] 1286404011413 oxyanion hole [active] 1286404011414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404011415 dimerization interface [polypeptide binding]; other site 1286404011416 putative DNA binding site [nucleotide binding]; other site 1286404011417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404011418 putative Zn2+ binding site [ion binding]; other site 1286404011419 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1286404011420 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1286404011421 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 1286404011422 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1286404011423 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404011424 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1286404011425 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1286404011426 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1286404011427 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286404011428 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286404011429 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1286404011430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404011431 inhibitor-cofactor binding pocket; inhibition site 1286404011432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011433 catalytic residue [active] 1286404011434 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1286404011435 nucleotide binding site [chemical binding]; other site 1286404011436 N-acetyl-L-glutamate binding site [chemical binding]; other site 1286404011437 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1286404011438 heterotetramer interface [polypeptide binding]; other site 1286404011439 active site pocket [active] 1286404011440 cleavage site 1286404011441 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1286404011442 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1286404011443 YqzH-like protein; Region: YqzH; pfam14164 1286404011444 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1286404011445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404011446 NAD(P) binding site [chemical binding]; other site 1286404011447 active site 1286404011448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404011449 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 1286404011450 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1286404011451 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1286404011452 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1286404011453 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1286404011454 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1286404011455 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1286404011456 putative L-serine binding site [chemical binding]; other site 1286404011457 ribonuclease Z; Region: RNase_Z; TIGR02651 1286404011458 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 1286404011459 magnesium-transporting ATPase; Provisional; Region: PRK15122 1286404011460 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1286404011461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1286404011462 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1286404011463 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1286404011464 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1286404011465 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1286404011466 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1286404011467 MgtC family; Region: MgtC; pfam02308 1286404011468 DNA polymerase IV; Validated; Region: PRK01810 1286404011469 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1286404011470 active site 1286404011471 DNA binding site [nucleotide binding] 1286404011472 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286404011473 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1286404011474 peptidase T-like protein; Region: PepT-like; TIGR01883 1286404011475 metal binding site [ion binding]; metal-binding site 1286404011476 putative dimer interface [polypeptide binding]; other site 1286404011477 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404011478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404011479 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 1286404011480 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286404011481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286404011482 Predicted membrane protein [Function unknown]; Region: COG4129 1286404011483 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1286404011484 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1286404011485 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1286404011486 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1286404011487 Walker A/P-loop; other site 1286404011488 ATP binding site [chemical binding]; other site 1286404011489 Q-loop/lid; other site 1286404011490 ABC transporter signature motif; other site 1286404011491 Walker B; other site 1286404011492 D-loop; other site 1286404011493 H-loop/switch region; other site 1286404011494 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1286404011495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404011496 dimer interface [polypeptide binding]; other site 1286404011497 conserved gate region; other site 1286404011498 putative PBP binding loops; other site 1286404011499 ABC-ATPase subunit interface; other site 1286404011500 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1286404011501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1286404011502 substrate binding pocket [chemical binding]; other site 1286404011503 membrane-bound complex binding site; other site 1286404011504 hinge residues; other site 1286404011505 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1286404011506 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1286404011507 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1286404011508 nudix motif; other site 1286404011509 Predicted membrane protein [Function unknown]; Region: COG2323 1286404011510 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1286404011511 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1286404011512 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1286404011513 E3 interaction surface; other site 1286404011514 lipoyl attachment site [posttranslational modification]; other site 1286404011515 e3 binding domain; Region: E3_binding; pfam02817 1286404011516 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1286404011517 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1286404011518 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1286404011519 alpha subunit interface [polypeptide binding]; other site 1286404011520 TPP binding site [chemical binding]; other site 1286404011521 heterodimer interface [polypeptide binding]; other site 1286404011522 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286404011523 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1286404011524 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1286404011525 tetramer interface [polypeptide binding]; other site 1286404011526 TPP-binding site [chemical binding]; other site 1286404011527 heterodimer interface [polypeptide binding]; other site 1286404011528 phosphorylation loop region [posttranslational modification] 1286404011529 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1286404011530 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1286404011531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404011532 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1286404011533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286404011534 nucleotide binding site [chemical binding]; other site 1286404011535 Acetokinase family; Region: Acetate_kinase; cl17229 1286404011536 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1286404011537 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1286404011538 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1286404011539 NAD binding site [chemical binding]; other site 1286404011540 Phe binding site; other site 1286404011541 phosphate butyryltransferase; Validated; Region: PRK07742 1286404011542 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1286404011543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404011544 putative active site [active] 1286404011545 heme pocket [chemical binding]; other site 1286404011546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404011547 putative active site [active] 1286404011548 heme pocket [chemical binding]; other site 1286404011549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404011550 Walker A motif; other site 1286404011551 ATP binding site [chemical binding]; other site 1286404011552 Walker B motif; other site 1286404011553 arginine finger; other site 1286404011554 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1286404011555 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1286404011556 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286404011557 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1286404011558 active site 1286404011559 catalytic site [active] 1286404011560 metal binding site [ion binding]; metal-binding site 1286404011561 dimer interface [polypeptide binding]; other site 1286404011562 YycC-like protein; Region: YycC; pfam14174 1286404011563 hypothetical protein; Provisional; Region: PRK06770 1286404011564 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1286404011565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404011566 active site 1286404011567 phosphorylation site [posttranslational modification] 1286404011568 intermolecular recognition site; other site 1286404011569 dimerization interface [polypeptide binding]; other site 1286404011570 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1286404011571 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1286404011572 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1286404011573 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1286404011574 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1286404011575 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1286404011576 Walker A/P-loop; other site 1286404011577 ATP binding site [chemical binding]; other site 1286404011578 Q-loop/lid; other site 1286404011579 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1286404011580 ABC transporter signature motif; other site 1286404011581 Walker B; other site 1286404011582 D-loop; other site 1286404011583 H-loop/switch region; other site 1286404011584 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1286404011585 arginine repressor; Provisional; Region: PRK04280 1286404011586 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1286404011587 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1286404011588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404011589 RNA binding surface [nucleotide binding]; other site 1286404011590 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1286404011591 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1286404011592 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1286404011593 TPP-binding site; other site 1286404011594 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1286404011595 PYR/PP interface [polypeptide binding]; other site 1286404011596 dimer interface [polypeptide binding]; other site 1286404011597 TPP binding site [chemical binding]; other site 1286404011598 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1286404011599 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1286404011600 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1286404011601 substrate binding pocket [chemical binding]; other site 1286404011602 chain length determination region; other site 1286404011603 substrate-Mg2+ binding site; other site 1286404011604 catalytic residues [active] 1286404011605 aspartate-rich region 1; other site 1286404011606 active site lid residues [active] 1286404011607 aspartate-rich region 2; other site 1286404011608 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1286404011609 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1286404011610 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1286404011611 generic binding surface II; other site 1286404011612 generic binding surface I; other site 1286404011613 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1286404011614 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1286404011615 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1286404011616 homodimer interface [polypeptide binding]; other site 1286404011617 NADP binding site [chemical binding]; other site 1286404011618 substrate binding site [chemical binding]; other site 1286404011619 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1286404011620 putative RNA binding site [nucleotide binding]; other site 1286404011621 Asp23 family; Region: Asp23; pfam03780 1286404011622 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1286404011623 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1286404011624 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1286404011625 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1286404011626 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1286404011627 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1286404011628 carboxyltransferase (CT) interaction site; other site 1286404011629 biotinylation site [posttranslational modification]; other site 1286404011630 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1286404011631 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1286404011632 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1286404011633 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1286404011634 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1286404011635 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1286404011636 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1286404011637 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1286404011638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404011639 Walker A motif; other site 1286404011640 ATP binding site [chemical binding]; other site 1286404011641 Walker B motif; other site 1286404011642 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1286404011643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404011644 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404011645 elongation factor P; Validated; Region: PRK00529 1286404011646 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1286404011647 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1286404011648 RNA binding site [nucleotide binding]; other site 1286404011649 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1286404011650 RNA binding site [nucleotide binding]; other site 1286404011651 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286404011652 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286404011653 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1286404011654 active site 1286404011655 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1286404011656 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1286404011657 trimer interface [polypeptide binding]; other site 1286404011658 active site 1286404011659 dimer interface [polypeptide binding]; other site 1286404011660 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1286404011661 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1286404011662 Carbon starvation protein CstA; Region: CstA; pfam02554 1286404011663 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1286404011664 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1286404011665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404011666 motif II; other site 1286404011667 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1286404011668 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1286404011669 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1286404011670 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1286404011671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404011672 FeS/SAM binding site; other site 1286404011673 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404011674 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1286404011675 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1286404011676 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404011677 active site residue [active] 1286404011678 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404011679 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404011680 DNA binding site [nucleotide binding] 1286404011681 domain linker motif; other site 1286404011682 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1286404011683 putative dimerization interface [polypeptide binding]; other site 1286404011684 putative ligand binding site [chemical binding]; other site 1286404011685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404011686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404011687 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404011688 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404011689 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 1286404011690 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1286404011691 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1286404011692 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1286404011693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404011694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404011695 Walker A/P-loop; other site 1286404011696 ATP binding site [chemical binding]; other site 1286404011697 Q-loop/lid; other site 1286404011698 ABC transporter signature motif; other site 1286404011699 Walker B; other site 1286404011700 D-loop; other site 1286404011701 H-loop/switch region; other site 1286404011702 Predicted transcriptional regulators [Transcription]; Region: COG1725 1286404011703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404011704 DNA-binding site [nucleotide binding]; DNA binding site 1286404011705 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 1286404011706 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1286404011707 tetramer interface [polypeptide binding]; other site 1286404011708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011709 catalytic residue [active] 1286404011710 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1286404011711 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1286404011712 tetramer interface [polypeptide binding]; other site 1286404011713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011714 catalytic residue [active] 1286404011715 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1286404011716 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1286404011717 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1286404011718 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286404011719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404011720 ATP binding site [chemical binding]; other site 1286404011721 putative Mg++ binding site [ion binding]; other site 1286404011722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404011723 nucleotide binding region [chemical binding]; other site 1286404011724 ATP-binding site [chemical binding]; other site 1286404011725 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1286404011726 YqzE-like protein; Region: YqzE; pfam14038 1286404011727 Shikimate kinase; Region: SKI; pfam01202 1286404011728 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1286404011729 ADP binding site [chemical binding]; other site 1286404011730 magnesium binding site [ion binding]; other site 1286404011731 putative shikimate binding site; other site 1286404011732 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1286404011733 ComG operon protein 7; Region: ComGG; pfam14173 1286404011734 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1286404011735 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1286404011736 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286404011737 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1286404011738 Type II/IV secretion system protein; Region: T2SE; pfam00437 1286404011739 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404011740 Walker A motif; other site 1286404011741 ATP binding site [chemical binding]; other site 1286404011742 Walker B motif; other site 1286404011743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404011744 putative DNA binding site [nucleotide binding]; other site 1286404011745 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1286404011746 putative Zn2+ binding site [ion binding]; other site 1286404011747 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1286404011748 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1286404011749 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286404011750 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 1286404011751 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1286404011752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1286404011753 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 1286404011754 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1286404011755 homodimer interface [polypeptide binding]; other site 1286404011756 active site 1286404011757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404011758 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404011759 Probable transposase; Region: OrfB_IS605; pfam01385 1286404011760 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286404011761 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1286404011762 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1286404011763 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1286404011764 substrate binding pocket [chemical binding]; other site 1286404011765 dimer interface [polypeptide binding]; other site 1286404011766 inhibitor binding site; inhibition site 1286404011767 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1286404011768 B12 binding site [chemical binding]; other site 1286404011769 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1286404011770 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1286404011771 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1286404011772 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1286404011773 FAD binding site [chemical binding]; other site 1286404011774 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1286404011775 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286404011776 homodimer interface [polypeptide binding]; other site 1286404011777 substrate-cofactor binding pocket; other site 1286404011778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011779 catalytic residue [active] 1286404011780 cystathionine beta-lyase; Provisional; Region: PRK08064 1286404011781 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286404011782 homodimer interface [polypeptide binding]; other site 1286404011783 substrate-cofactor binding pocket; other site 1286404011784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404011785 catalytic residue [active] 1286404011786 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404011787 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286404011788 catalytic triad [active] 1286404011789 conserved cis-peptide bond; other site 1286404011790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404011791 dimerization interface [polypeptide binding]; other site 1286404011792 putative DNA binding site [nucleotide binding]; other site 1286404011793 putative Zn2+ binding site [ion binding]; other site 1286404011794 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1286404011795 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286404011796 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1286404011797 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1286404011798 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1286404011799 nucleotide binding site [chemical binding]; other site 1286404011800 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1286404011801 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1286404011802 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1286404011803 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1286404011804 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1286404011805 active site 1286404011806 Substrate binding site; other site 1286404011807 Mg++ binding site; other site 1286404011808 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1286404011809 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1286404011810 active site 1286404011811 metal binding site [ion binding]; metal-binding site 1286404011812 substrate binding site [chemical binding]; other site 1286404011813 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1286404011814 PhoU domain; Region: PhoU; pfam01895 1286404011815 PhoU domain; Region: PhoU; pfam01895 1286404011816 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1286404011817 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1286404011818 Walker A/P-loop; other site 1286404011819 ATP binding site [chemical binding]; other site 1286404011820 Q-loop/lid; other site 1286404011821 ABC transporter signature motif; other site 1286404011822 Walker B; other site 1286404011823 D-loop; other site 1286404011824 H-loop/switch region; other site 1286404011825 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1286404011826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404011827 dimer interface [polypeptide binding]; other site 1286404011828 conserved gate region; other site 1286404011829 putative PBP binding loops; other site 1286404011830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1286404011831 ABC-ATPase subunit interface; other site 1286404011832 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1286404011833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404011834 dimer interface [polypeptide binding]; other site 1286404011835 conserved gate region; other site 1286404011836 putative PBP binding loops; other site 1286404011837 ABC-ATPase subunit interface; other site 1286404011838 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1286404011839 PBP superfamily domain; Region: PBP_like_2; cl17296 1286404011840 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404011841 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404011842 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404011843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404011844 putative substrate translocation pore; other site 1286404011845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404011846 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1286404011847 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1286404011848 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1286404011849 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1286404011850 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1286404011851 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1286404011852 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1286404011853 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1286404011854 metal binding site 2 [ion binding]; metal-binding site 1286404011855 putative DNA binding helix; other site 1286404011856 metal binding site 1 [ion binding]; metal-binding site 1286404011857 dimer interface [polypeptide binding]; other site 1286404011858 structural Zn2+ binding site [ion binding]; other site 1286404011859 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1286404011860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404011861 ABC-ATPase subunit interface; other site 1286404011862 dimer interface [polypeptide binding]; other site 1286404011863 putative PBP binding regions; other site 1286404011864 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1286404011865 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1286404011866 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404011867 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404011868 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404011869 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404011870 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1286404011871 endonuclease IV; Provisional; Region: PRK01060 1286404011872 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1286404011873 AP (apurinic/apyrimidinic) site pocket; other site 1286404011874 DNA interaction; other site 1286404011875 Metal-binding active site; metal-binding site 1286404011876 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286404011877 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1286404011878 ATP binding site [chemical binding]; other site 1286404011879 Mg++ binding site [ion binding]; other site 1286404011880 motif III; other site 1286404011881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404011882 nucleotide binding region [chemical binding]; other site 1286404011883 ATP-binding site [chemical binding]; other site 1286404011884 YqfQ-like protein; Region: YqfQ; pfam14181 1286404011885 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1286404011886 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1286404011887 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1286404011888 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1286404011889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1286404011890 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1286404011891 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1286404011892 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1286404011893 Family of unknown function (DUF633); Region: DUF633; pfam04816 1286404011894 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286404011895 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286404011896 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1286404011897 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1286404011898 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1286404011899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404011900 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1286404011901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404011902 DNA binding residues [nucleotide binding] 1286404011903 DNA primase; Validated; Region: dnaG; PRK05667 1286404011904 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1286404011905 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1286404011906 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1286404011907 active site 1286404011908 metal binding site [ion binding]; metal-binding site 1286404011909 interdomain interaction site; other site 1286404011910 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1286404011911 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1286404011912 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1286404011913 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1286404011914 HTH domain; Region: HTH_11; pfam08279 1286404011915 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1286404011916 FOG: CBS domain [General function prediction only]; Region: COG0517 1286404011917 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1286404011918 Recombination protein O N terminal; Region: RecO_N; pfam11967 1286404011919 Recombination protein O C terminal; Region: RecO_C; pfam02565 1286404011920 YqzL-like protein; Region: YqzL; pfam14006 1286404011921 GTPase Era; Reviewed; Region: era; PRK00089 1286404011922 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1286404011923 G1 box; other site 1286404011924 GTP/Mg2+ binding site [chemical binding]; other site 1286404011925 Switch I region; other site 1286404011926 G2 box; other site 1286404011927 Switch II region; other site 1286404011928 G3 box; other site 1286404011929 G4 box; other site 1286404011930 G5 box; other site 1286404011931 KH domain; Region: KH_2; pfam07650 1286404011932 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1286404011933 active site 1286404011934 catalytic motif [active] 1286404011935 Zn binding site [ion binding]; other site 1286404011936 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1286404011937 metal-binding heat shock protein; Provisional; Region: PRK00016 1286404011938 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1286404011939 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1286404011940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404011941 Zn2+ binding site [ion binding]; other site 1286404011942 Mg2+ binding site [ion binding]; other site 1286404011943 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1286404011944 PhoH-like protein; Region: PhoH; pfam02562 1286404011945 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1286404011946 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1286404011947 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1286404011948 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1286404011949 Yqey-like protein; Region: YqeY; pfam09424 1286404011950 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1286404011951 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1286404011952 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1286404011953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404011954 FeS/SAM binding site; other site 1286404011955 TRAM domain; Region: TRAM; cl01282 1286404011956 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1286404011957 RNA methyltransferase, RsmE family; Region: TIGR00046 1286404011958 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1286404011959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404011960 S-adenosylmethionine binding site [chemical binding]; other site 1286404011961 chaperone protein DnaJ; Provisional; Region: PRK14280 1286404011962 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1286404011963 HSP70 interaction site [polypeptide binding]; other site 1286404011964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1286404011965 substrate binding site [polypeptide binding]; other site 1286404011966 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1286404011967 Zn binding sites [ion binding]; other site 1286404011968 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1286404011969 dimer interface [polypeptide binding]; other site 1286404011970 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1286404011971 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1286404011972 nucleotide binding site [chemical binding]; other site 1286404011973 NEF interaction site [polypeptide binding]; other site 1286404011974 SBD interface [polypeptide binding]; other site 1286404011975 GrpE; Region: GrpE; pfam01025 1286404011976 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1286404011977 dimer interface [polypeptide binding]; other site 1286404011978 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1286404011979 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1286404011980 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1286404011981 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1286404011982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404011983 FeS/SAM binding site; other site 1286404011984 HemN C-terminal domain; Region: HemN_C; pfam06969 1286404011985 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404011986 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1286404011987 GTP-binding protein LepA; Provisional; Region: PRK05433 1286404011988 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1286404011989 G1 box; other site 1286404011990 putative GEF interaction site [polypeptide binding]; other site 1286404011991 GTP/Mg2+ binding site [chemical binding]; other site 1286404011992 Switch I region; other site 1286404011993 G2 box; other site 1286404011994 G3 box; other site 1286404011995 Switch II region; other site 1286404011996 G4 box; other site 1286404011997 G5 box; other site 1286404011998 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1286404011999 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1286404012000 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1286404012001 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1286404012002 germination protease; Provisional; Region: PRK02858 1286404012003 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1286404012004 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1286404012005 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1286404012006 YqzM-like protein; Region: YqzM; pfam14141 1286404012007 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1286404012008 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1286404012009 Competence protein; Region: Competence; pfam03772 1286404012010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404012011 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1286404012012 catalytic motif [active] 1286404012013 Zn binding site [ion binding]; other site 1286404012014 SLBB domain; Region: SLBB; pfam10531 1286404012015 comEA protein; Region: comE; TIGR01259 1286404012016 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1286404012017 late competence protein ComER; Validated; Region: PRK07680 1286404012018 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1286404012019 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1286404012020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404012021 S-adenosylmethionine binding site [chemical binding]; other site 1286404012022 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 1286404012023 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1286404012024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404012025 Zn2+ binding site [ion binding]; other site 1286404012026 Mg2+ binding site [ion binding]; other site 1286404012027 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1286404012028 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1286404012029 active site 1286404012030 (T/H)XGH motif; other site 1286404012031 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1286404012032 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1286404012033 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286404012034 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286404012035 shikimate binding site; other site 1286404012036 NAD(P) binding site [chemical binding]; other site 1286404012037 GTPase YqeH; Provisional; Region: PRK13796 1286404012038 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1286404012039 GTP/Mg2+ binding site [chemical binding]; other site 1286404012040 G4 box; other site 1286404012041 G5 box; other site 1286404012042 G1 box; other site 1286404012043 Switch I region; other site 1286404012044 G2 box; other site 1286404012045 G3 box; other site 1286404012046 Switch II region; other site 1286404012047 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1286404012048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404012049 active site 1286404012050 motif I; other site 1286404012051 motif II; other site 1286404012052 Sporulation inhibitor A; Region: Sda; pfam08970 1286404012053 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1286404012054 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1286404012055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404012056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404012057 DNA binding residues [nucleotide binding] 1286404012058 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1286404012059 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1286404012060 dimer interface [polypeptide binding]; other site 1286404012061 FMN binding site [chemical binding]; other site 1286404012062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1286404012063 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1286404012064 synthetase active site [active] 1286404012065 NTP binding site [chemical binding]; other site 1286404012066 metal binding site [ion binding]; metal-binding site 1286404012067 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1286404012068 dimer interface [polypeptide binding]; other site 1286404012069 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1286404012070 active site 1286404012071 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404012072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404012073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404012074 Coenzyme A binding pocket [chemical binding]; other site 1286404012075 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404012076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404012077 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1286404012078 catalytic site [active] 1286404012079 DoxX; Region: DoxX; cl17842 1286404012080 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1286404012081 catalytic core [active] 1286404012082 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1286404012083 translocation protein TolB; Provisional; Region: tolB; PRK04792 1286404012084 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1286404012085 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1286404012086 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1286404012087 putative active site [active] 1286404012088 catalytic triad [active] 1286404012089 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1286404012090 putative integrin binding motif; other site 1286404012091 PA/protease domain interface [polypeptide binding]; other site 1286404012092 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1286404012093 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1286404012094 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1286404012095 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1286404012096 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1286404012097 cofactor binding site; other site 1286404012098 metal binding site [ion binding]; metal-binding site 1286404012099 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1286404012100 aromatic arch; other site 1286404012101 DCoH dimer interaction site [polypeptide binding]; other site 1286404012102 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1286404012103 DCoH tetramer interaction site [polypeptide binding]; other site 1286404012104 substrate binding site [chemical binding]; other site 1286404012105 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1286404012106 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1286404012107 putative metal binding site [ion binding]; other site 1286404012108 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1286404012109 active site 1286404012110 metal binding site [ion binding]; metal-binding site 1286404012111 Predicted membrane protein [Function unknown]; Region: COG2259 1286404012112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404012113 non-specific DNA binding site [nucleotide binding]; other site 1286404012114 salt bridge; other site 1286404012115 sequence-specific DNA binding site [nucleotide binding]; other site 1286404012116 Cupin domain; Region: Cupin_2; pfam07883 1286404012117 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1286404012118 active site 2 [active] 1286404012119 active site 1 [active] 1286404012120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404012121 Coenzyme A binding pocket [chemical binding]; other site 1286404012122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404012123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404012124 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286404012125 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1286404012126 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286404012127 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286404012128 Walker A/P-loop; other site 1286404012129 ATP binding site [chemical binding]; other site 1286404012130 Q-loop/lid; other site 1286404012131 ABC transporter signature motif; other site 1286404012132 Walker B; other site 1286404012133 D-loop; other site 1286404012134 H-loop/switch region; other site 1286404012135 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286404012136 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404012137 ABC-ATPase subunit interface; other site 1286404012138 dimer interface [polypeptide binding]; other site 1286404012139 putative PBP binding regions; other site 1286404012140 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286404012141 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286404012142 intersubunit interface [polypeptide binding]; other site 1286404012143 YrhC-like protein; Region: YrhC; pfam14143 1286404012144 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1286404012145 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1286404012146 putative catalytic cysteine [active] 1286404012147 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1286404012148 putative active site [active] 1286404012149 metal binding site [ion binding]; metal-binding site 1286404012150 cystathionine beta-lyase; Provisional; Region: PRK07671 1286404012151 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286404012152 homodimer interface [polypeptide binding]; other site 1286404012153 substrate-cofactor binding pocket; other site 1286404012154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404012155 catalytic residue [active] 1286404012156 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1286404012157 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286404012158 dimer interface [polypeptide binding]; other site 1286404012159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404012160 catalytic residue [active] 1286404012161 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1286404012162 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1286404012163 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1286404012164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404012165 S-adenosylmethionine binding site [chemical binding]; other site 1286404012166 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1286404012167 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1286404012168 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1286404012169 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1286404012170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404012171 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1286404012172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1286404012173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1286404012174 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1286404012175 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1286404012176 ATP-binding site [chemical binding]; other site 1286404012177 Sugar specificity; other site 1286404012178 Pyrimidine base specificity; other site 1286404012179 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286404012180 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286404012181 Peptidase family U32; Region: Peptidase_U32; pfam01136 1286404012182 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1286404012183 Protein of unknown function (DUF556); Region: DUF556; cl00822 1286404012184 Peptidase family U32; Region: Peptidase_U32; pfam01136 1286404012185 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1286404012186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404012187 S-adenosylmethionine binding site [chemical binding]; other site 1286404012188 YceG-like family; Region: YceG; pfam02618 1286404012189 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1286404012190 dimerization interface [polypeptide binding]; other site 1286404012191 hypothetical protein; Provisional; Region: PRK13678 1286404012192 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1286404012193 hypothetical protein; Provisional; Region: PRK05473 1286404012194 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1286404012195 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1286404012196 motif 1; other site 1286404012197 active site 1286404012198 motif 2; other site 1286404012199 motif 3; other site 1286404012200 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286404012201 DHHA1 domain; Region: DHHA1; pfam02272 1286404012202 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286404012203 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286404012204 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1286404012205 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1286404012206 AAA domain; Region: AAA_30; pfam13604 1286404012207 Family description; Region: UvrD_C_2; pfam13538 1286404012208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404012209 TPR motif; other site 1286404012210 binding surface 1286404012211 TPR repeat; Region: TPR_11; pfam13414 1286404012212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404012213 binding surface 1286404012214 TPR motif; other site 1286404012215 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404012216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404012217 binding surface 1286404012218 TPR motif; other site 1286404012219 TPR repeat; Region: TPR_11; pfam13414 1286404012220 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1286404012221 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1286404012222 Ligand Binding Site [chemical binding]; other site 1286404012223 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1286404012224 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1286404012225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404012226 catalytic residue [active] 1286404012227 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286404012228 Transcriptional regulator; Region: Rrf2; pfam02082 1286404012229 recombination factor protein RarA; Reviewed; Region: PRK13342 1286404012230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404012231 Walker A motif; other site 1286404012232 ATP binding site [chemical binding]; other site 1286404012233 Walker B motif; other site 1286404012234 arginine finger; other site 1286404012235 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1286404012236 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1286404012237 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1286404012238 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1286404012239 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1286404012240 putative ATP binding site [chemical binding]; other site 1286404012241 putative substrate interface [chemical binding]; other site 1286404012242 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1286404012243 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1286404012244 dimer interface [polypeptide binding]; other site 1286404012245 anticodon binding site; other site 1286404012246 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1286404012247 homodimer interface [polypeptide binding]; other site 1286404012248 motif 1; other site 1286404012249 active site 1286404012250 motif 2; other site 1286404012251 GAD domain; Region: GAD; pfam02938 1286404012252 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1286404012253 motif 3; other site 1286404012254 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1286404012255 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1286404012256 dimer interface [polypeptide binding]; other site 1286404012257 motif 1; other site 1286404012258 active site 1286404012259 motif 2; other site 1286404012260 motif 3; other site 1286404012261 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1286404012262 anticodon binding site; other site 1286404012263 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1286404012264 putative active site [active] 1286404012265 dimerization interface [polypeptide binding]; other site 1286404012266 putative tRNAtyr binding site [nucleotide binding]; other site 1286404012267 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1286404012268 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404012269 Zn2+ binding site [ion binding]; other site 1286404012270 Mg2+ binding site [ion binding]; other site 1286404012271 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1286404012272 synthetase active site [active] 1286404012273 NTP binding site [chemical binding]; other site 1286404012274 metal binding site [ion binding]; metal-binding site 1286404012275 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1286404012276 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1286404012277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404012278 active site 1286404012279 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1286404012280 DHH family; Region: DHH; pfam01368 1286404012281 DHHA1 domain; Region: DHHA1; pfam02272 1286404012282 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1286404012283 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1286404012284 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1286404012285 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1286404012286 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1286404012287 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1286404012288 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1286404012289 Protein export membrane protein; Region: SecD_SecF; pfam02355 1286404012290 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1286404012291 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1286404012292 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1286404012293 Predicted membrane protein [Function unknown]; Region: COG2323 1286404012294 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1286404012295 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1286404012296 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1286404012297 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1286404012298 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1286404012299 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1286404012300 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1286404012301 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1286404012302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404012303 Walker A motif; other site 1286404012304 ATP binding site [chemical binding]; other site 1286404012305 Walker B motif; other site 1286404012306 arginine finger; other site 1286404012307 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1286404012308 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1286404012309 RuvA N terminal domain; Region: RuvA_N; pfam01330 1286404012310 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1286404012311 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286404012312 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1286404012313 putative ligand binding residues [chemical binding]; other site 1286404012314 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1286404012315 BofC C-terminal domain; Region: BofC_C; pfam08955 1286404012316 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1286404012317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404012318 quinolinate synthetase; Provisional; Region: PRK09375 1286404012319 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1286404012320 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1286404012321 dimerization interface [polypeptide binding]; other site 1286404012322 active site 1286404012323 L-aspartate oxidase; Provisional; Region: PRK08071 1286404012324 L-aspartate oxidase; Provisional; Region: PRK06175 1286404012325 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286404012326 cysteine desulfurase; Provisional; Region: PRK02948 1286404012327 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1286404012328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404012329 catalytic residue [active] 1286404012330 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1286404012331 HTH domain; Region: HTH_11; pfam08279 1286404012332 3H domain; Region: 3H; pfam02829 1286404012333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1286404012334 MOSC domain; Region: MOSC; pfam03473 1286404012335 3-alpha domain; Region: 3-alpha; pfam03475 1286404012336 prephenate dehydratase; Provisional; Region: PRK11898 1286404012337 Prephenate dehydratase; Region: PDT; pfam00800 1286404012338 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1286404012339 putative L-Phe binding site [chemical binding]; other site 1286404012340 FtsX-like permease family; Region: FtsX; pfam02687 1286404012341 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404012342 FtsX-like permease family; Region: FtsX; pfam02687 1286404012343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404012344 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404012345 Walker A/P-loop; other site 1286404012346 ATP binding site [chemical binding]; other site 1286404012347 Q-loop/lid; other site 1286404012348 ABC transporter signature motif; other site 1286404012349 Walker B; other site 1286404012350 D-loop; other site 1286404012351 H-loop/switch region; other site 1286404012352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404012353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1286404012354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404012355 ATP binding site [chemical binding]; other site 1286404012356 Mg2+ binding site [ion binding]; other site 1286404012357 G-X-G motif; other site 1286404012358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404012359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404012360 active site 1286404012361 phosphorylation site [posttranslational modification] 1286404012362 intermolecular recognition site; other site 1286404012363 dimerization interface [polypeptide binding]; other site 1286404012364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404012365 DNA binding site [nucleotide binding] 1286404012366 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1286404012367 GTP1/OBG; Region: GTP1_OBG; pfam01018 1286404012368 Obg GTPase; Region: Obg; cd01898 1286404012369 G1 box; other site 1286404012370 GTP/Mg2+ binding site [chemical binding]; other site 1286404012371 Switch I region; other site 1286404012372 G2 box; other site 1286404012373 G3 box; other site 1286404012374 Switch II region; other site 1286404012375 G4 box; other site 1286404012376 G5 box; other site 1286404012377 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1286404012378 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1286404012379 hypothetical protein; Provisional; Region: PRK14553 1286404012380 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1286404012381 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1286404012382 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1286404012383 homodimer interface [polypeptide binding]; other site 1286404012384 oligonucleotide binding site [chemical binding]; other site 1286404012385 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1286404012386 Peptidase family M50; Region: Peptidase_M50; pfam02163 1286404012387 active site 1286404012388 putative substrate binding region [chemical binding]; other site 1286404012389 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404012390 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404012391 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1286404012392 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1286404012393 Switch I; other site 1286404012394 Switch II; other site 1286404012395 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1286404012396 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1286404012397 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1286404012398 rod shape-determining protein MreC; Provisional; Region: PRK13922 1286404012399 rod shape-determining protein MreC; Region: MreC; pfam04085 1286404012400 rod shape-determining protein MreB; Provisional; Region: PRK13927 1286404012401 MreB and similar proteins; Region: MreB_like; cd10225 1286404012402 nucleotide binding site [chemical binding]; other site 1286404012403 Mg binding site [ion binding]; other site 1286404012404 putative protofilament interaction site [polypeptide binding]; other site 1286404012405 RodZ interaction site [polypeptide binding]; other site 1286404012406 hypothetical protein; Reviewed; Region: PRK00024 1286404012407 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1286404012408 MPN+ (JAMM) motif; other site 1286404012409 Zinc-binding site [ion binding]; other site 1286404012410 Maf-like protein; Region: Maf; pfam02545 1286404012411 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1286404012412 active site 1286404012413 dimer interface [polypeptide binding]; other site 1286404012414 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1286404012415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286404012416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286404012417 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1286404012418 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1286404012419 active site 1286404012420 HIGH motif; other site 1286404012421 nucleotide binding site [chemical binding]; other site 1286404012422 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286404012423 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1286404012424 active site 1286404012425 KMSKS motif; other site 1286404012426 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1286404012427 tRNA binding surface [nucleotide binding]; other site 1286404012428 anticodon binding site; other site 1286404012429 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1286404012430 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1286404012431 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1286404012432 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1286404012433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1286404012434 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1286404012435 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1286404012436 inhibitor-cofactor binding pocket; inhibition site 1286404012437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404012438 catalytic residue [active] 1286404012439 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1286404012440 dimer interface [polypeptide binding]; other site 1286404012441 active site 1286404012442 Schiff base residues; other site 1286404012443 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1286404012444 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1286404012445 active site 1286404012446 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1286404012447 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1286404012448 domain interfaces; other site 1286404012449 active site 1286404012450 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1286404012451 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1286404012452 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1286404012453 tRNA; other site 1286404012454 putative tRNA binding site [nucleotide binding]; other site 1286404012455 putative NADP binding site [chemical binding]; other site 1286404012456 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1286404012457 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286404012458 MarR family; Region: MarR; pfam01047 1286404012459 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1286404012460 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1286404012461 G1 box; other site 1286404012462 GTP/Mg2+ binding site [chemical binding]; other site 1286404012463 Switch I region; other site 1286404012464 G2 box; other site 1286404012465 G3 box; other site 1286404012466 Switch II region; other site 1286404012467 G4 box; other site 1286404012468 G5 box; other site 1286404012469 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1286404012470 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1286404012471 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1286404012472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404012473 Walker A motif; other site 1286404012474 ATP binding site [chemical binding]; other site 1286404012475 Walker B motif; other site 1286404012476 arginine finger; other site 1286404012477 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1286404012478 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1286404012479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404012480 Walker A motif; other site 1286404012481 ATP binding site [chemical binding]; other site 1286404012482 Walker B motif; other site 1286404012483 arginine finger; other site 1286404012484 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1286404012485 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1286404012486 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1286404012487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404012488 Walker A motif; other site 1286404012489 ATP binding site [chemical binding]; other site 1286404012490 Walker B motif; other site 1286404012491 arginine finger; other site 1286404012492 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1286404012493 trigger factor; Provisional; Region: tig; PRK01490 1286404012494 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1286404012495 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1286404012496 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1286404012497 pentamer interface [polypeptide binding]; other site 1286404012498 dodecaamer interface [polypeptide binding]; other site 1286404012499 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1286404012500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404012501 non-specific DNA binding site [nucleotide binding]; other site 1286404012502 salt bridge; other site 1286404012503 sequence-specific DNA binding site [nucleotide binding]; other site 1286404012504 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1286404012505 Helix-turn-helix domain; Region: HTH_36; pfam13730 1286404012506 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404012507 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286404012508 catalytic residues [active] 1286404012509 catalytic nucleophile [active] 1286404012510 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286404012511 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286404012512 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286404012513 Synaptic Site I dimer interface [polypeptide binding]; other site 1286404012514 DNA binding site [nucleotide binding] 1286404012515 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1286404012516 trimer interface [polypeptide binding]; other site 1286404012517 active site 1286404012518 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404012519 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1286404012520 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404012521 active site 1286404012522 catalytic residues [active] 1286404012523 DNA binding site [nucleotide binding] 1286404012524 Int/Topo IB signature motif; other site 1286404012525 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1286404012526 active site 1286404012527 metal binding site [ion binding]; metal-binding site 1286404012528 homotetramer interface [polypeptide binding]; other site 1286404012529 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1286404012530 active site 1286404012531 dimerization interface [polypeptide binding]; other site 1286404012532 ribonuclease PH; Reviewed; Region: rph; PRK00173 1286404012533 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1286404012534 hexamer interface [polypeptide binding]; other site 1286404012535 active site 1286404012536 Sporulation and spore germination; Region: Germane; pfam10646 1286404012537 Spore germination protein [General function prediction only]; Region: COG5401 1286404012538 Sporulation and spore germination; Region: Germane; pfam10646 1286404012539 glutamate racemase; Provisional; Region: PRK00865 1286404012540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404012541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404012542 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1286404012543 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1286404012544 potential catalytic triad [active] 1286404012545 conserved cys residue [active] 1286404012546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404012547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404012548 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1286404012549 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1286404012550 potential catalytic triad [active] 1286404012551 conserved cys residue [active] 1286404012552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404012553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404012554 DNA binding residues [nucleotide binding] 1286404012555 dimerization interface [polypeptide binding]; other site 1286404012556 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1286404012557 putative deaminase; Validated; Region: PRK06846 1286404012558 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1286404012559 active site 1286404012560 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1286404012561 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404012562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404012563 non-specific DNA binding site [nucleotide binding]; other site 1286404012564 salt bridge; other site 1286404012565 sequence-specific DNA binding site [nucleotide binding]; other site 1286404012566 Cupin domain; Region: Cupin_2; pfam07883 1286404012567 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1286404012568 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1286404012569 amphipathic channel; other site 1286404012570 Asn-Pro-Ala signature motifs; other site 1286404012571 Predicted transcriptional regulator [Transcription]; Region: COG1959 1286404012572 Transcriptional regulator; Region: Rrf2; pfam02082 1286404012573 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1286404012574 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1286404012575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404012576 Walker A/P-loop; other site 1286404012577 ATP binding site [chemical binding]; other site 1286404012578 Q-loop/lid; other site 1286404012579 ABC transporter signature motif; other site 1286404012580 Walker B; other site 1286404012581 D-loop; other site 1286404012582 H-loop/switch region; other site 1286404012583 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1286404012584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404012585 active site 1286404012586 motif I; other site 1286404012587 motif II; other site 1286404012588 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1286404012589 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1286404012590 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1286404012591 ligand binding site [chemical binding]; other site 1286404012592 flagellar motor protein MotA; Validated; Region: PRK08124 1286404012593 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1286404012594 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1286404012595 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1286404012596 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1286404012597 active site 1286404012598 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1286404012599 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1286404012600 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1286404012601 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1286404012602 L-aspartate oxidase; Provisional; Region: PRK06175 1286404012603 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1286404012604 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1286404012605 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1286404012606 putative Iron-sulfur protein interface [polypeptide binding]; other site 1286404012607 proximal heme binding site [chemical binding]; other site 1286404012608 distal heme binding site [chemical binding]; other site 1286404012609 putative dimer interface [polypeptide binding]; other site 1286404012610 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1286404012611 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1286404012612 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1286404012613 GIY-YIG motif/motif A; other site 1286404012614 active site 1286404012615 catalytic site [active] 1286404012616 putative DNA binding site [nucleotide binding]; other site 1286404012617 metal binding site [ion binding]; metal-binding site 1286404012618 UvrB/uvrC motif; Region: UVR; pfam02151 1286404012619 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1286404012620 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404012621 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1286404012622 catalytic residues [active] 1286404012623 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1286404012624 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1286404012625 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1286404012626 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1286404012627 Ligand binding site [chemical binding]; other site 1286404012628 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1286404012629 enoyl-CoA hydratase; Provisional; Region: PRK07658 1286404012630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286404012631 substrate binding site [chemical binding]; other site 1286404012632 oxyanion hole (OAH) forming residues; other site 1286404012633 trimer interface [polypeptide binding]; other site 1286404012634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1286404012635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404012636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404012637 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1286404012638 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1286404012639 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1286404012640 acyl-activating enzyme (AAE) consensus motif; other site 1286404012641 putative AMP binding site [chemical binding]; other site 1286404012642 putative active site [active] 1286404012643 putative CoA binding site [chemical binding]; other site 1286404012644 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1286404012645 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1286404012646 siderophore binding site; other site 1286404012647 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404012648 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404012649 ABC-ATPase subunit interface; other site 1286404012650 dimer interface [polypeptide binding]; other site 1286404012651 putative PBP binding regions; other site 1286404012652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404012653 ABC-ATPase subunit interface; other site 1286404012654 dimer interface [polypeptide binding]; other site 1286404012655 putative PBP binding regions; other site 1286404012656 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1286404012657 DinB family; Region: DinB; pfam05163 1286404012658 DinB superfamily; Region: DinB_2; pfam12867 1286404012659 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1286404012660 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1286404012661 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1286404012662 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404012663 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1286404012664 Walker A/P-loop; other site 1286404012665 ATP binding site [chemical binding]; other site 1286404012666 Q-loop/lid; other site 1286404012667 ABC transporter signature motif; other site 1286404012668 Walker B; other site 1286404012669 D-loop; other site 1286404012670 H-loop/switch region; other site 1286404012671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404012672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404012673 dimer interface [polypeptide binding]; other site 1286404012674 phosphorylation site [posttranslational modification] 1286404012675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404012676 ATP binding site [chemical binding]; other site 1286404012677 Mg2+ binding site [ion binding]; other site 1286404012678 G-X-G motif; other site 1286404012679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404012680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404012681 active site 1286404012682 phosphorylation site [posttranslational modification] 1286404012683 intermolecular recognition site; other site 1286404012684 dimerization interface [polypeptide binding]; other site 1286404012685 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404012686 DNA binding site [nucleotide binding] 1286404012687 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1286404012688 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1286404012689 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1286404012690 putative RNA binding site [nucleotide binding]; other site 1286404012691 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1286404012692 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 1286404012693 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1286404012694 active site 1286404012695 catalytic site [active] 1286404012696 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286404012697 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286404012698 Walker A/P-loop; other site 1286404012699 ATP binding site [chemical binding]; other site 1286404012700 Q-loop/lid; other site 1286404012701 ABC transporter signature motif; other site 1286404012702 Walker B; other site 1286404012703 D-loop; other site 1286404012704 H-loop/switch region; other site 1286404012705 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286404012706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404012707 ABC-ATPase subunit interface; other site 1286404012708 dimer interface [polypeptide binding]; other site 1286404012709 putative PBP binding regions; other site 1286404012710 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1286404012711 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286404012712 intersubunit interface [polypeptide binding]; other site 1286404012713 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012714 heme-binding site [chemical binding]; other site 1286404012715 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012716 heme-binding site [chemical binding]; other site 1286404012717 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012718 heme-binding site [chemical binding]; other site 1286404012719 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012720 heme-binding site [chemical binding]; other site 1286404012721 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012722 heme-binding site [chemical binding]; other site 1286404012723 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012724 heme-binding site [chemical binding]; other site 1286404012725 heme uptake protein IsdC; Region: IsdC; TIGR03656 1286404012726 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1286404012727 heme-binding site [chemical binding]; other site 1286404012728 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1286404012729 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1286404012730 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1286404012731 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404012732 RNA binding surface [nucleotide binding]; other site 1286404012733 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1286404012734 probable active site [active] 1286404012735 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1286404012736 MutS domain III; Region: MutS_III; pfam05192 1286404012737 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1286404012738 Walker A/P-loop; other site 1286404012739 ATP binding site [chemical binding]; other site 1286404012740 Q-loop/lid; other site 1286404012741 ABC transporter signature motif; other site 1286404012742 Walker B; other site 1286404012743 D-loop; other site 1286404012744 H-loop/switch region; other site 1286404012745 Smr domain; Region: Smr; pfam01713 1286404012746 hypothetical protein; Provisional; Region: PRK08609 1286404012747 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1286404012748 active site 1286404012749 primer binding site [nucleotide binding]; other site 1286404012750 NTP binding site [chemical binding]; other site 1286404012751 metal binding triad [ion binding]; metal-binding site 1286404012752 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1286404012753 active site 1286404012754 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1286404012755 Colicin V production protein; Region: Colicin_V; pfam02674 1286404012756 cell division protein ZapA; Provisional; Region: PRK14126 1286404012757 ribonuclease HIII; Provisional; Region: PRK00996 1286404012758 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1286404012759 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1286404012760 RNA/DNA hybrid binding site [nucleotide binding]; other site 1286404012761 active site 1286404012762 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1286404012763 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1286404012764 putative dimer interface [polypeptide binding]; other site 1286404012765 putative anticodon binding site; other site 1286404012766 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1286404012767 homodimer interface [polypeptide binding]; other site 1286404012768 motif 1; other site 1286404012769 motif 2; other site 1286404012770 active site 1286404012771 motif 3; other site 1286404012772 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1286404012773 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1286404012774 putative tRNA-binding site [nucleotide binding]; other site 1286404012775 B3/4 domain; Region: B3_4; pfam03483 1286404012776 tRNA synthetase B5 domain; Region: B5; smart00874 1286404012777 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1286404012778 dimer interface [polypeptide binding]; other site 1286404012779 motif 1; other site 1286404012780 motif 3; other site 1286404012781 motif 2; other site 1286404012782 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1286404012783 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1286404012784 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1286404012785 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1286404012786 dimer interface [polypeptide binding]; other site 1286404012787 motif 1; other site 1286404012788 active site 1286404012789 motif 2; other site 1286404012790 motif 3; other site 1286404012791 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1286404012792 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1286404012793 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1286404012794 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1286404012795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404012796 Zn2+ binding site [ion binding]; other site 1286404012797 Mg2+ binding site [ion binding]; other site 1286404012798 CAAX protease self-immunity; Region: Abi; pfam02517 1286404012799 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286404012800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404012801 putative substrate translocation pore; other site 1286404012802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404012803 HlyD family secretion protein; Region: HlyD_3; pfam13437 1286404012804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404012805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404012806 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1286404012807 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1286404012808 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1286404012809 oligomer interface [polypeptide binding]; other site 1286404012810 active site 1286404012811 metal binding site [ion binding]; metal-binding site 1286404012812 dUTPase; Region: dUTPase_2; pfam08761 1286404012813 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1286404012814 active site 1286404012815 homodimer interface [polypeptide binding]; other site 1286404012816 metal binding site [ion binding]; metal-binding site 1286404012817 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1286404012818 23S rRNA binding site [nucleotide binding]; other site 1286404012819 L21 binding site [polypeptide binding]; other site 1286404012820 L13 binding site [polypeptide binding]; other site 1286404012821 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1286404012822 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1286404012823 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1286404012824 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1286404012825 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1286404012826 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1286404012827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1286404012828 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1286404012829 active site 1286404012830 dimer interface [polypeptide binding]; other site 1286404012831 motif 1; other site 1286404012832 motif 2; other site 1286404012833 motif 3; other site 1286404012834 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1286404012835 anticodon binding site; other site 1286404012836 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1286404012837 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1286404012838 primosomal protein DnaI; Reviewed; Region: PRK08939 1286404012839 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1286404012840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404012841 Walker A motif; other site 1286404012842 ATP binding site [chemical binding]; other site 1286404012843 Walker B motif; other site 1286404012844 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1286404012845 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1286404012846 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1286404012847 ATP cone domain; Region: ATP-cone; pfam03477 1286404012848 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1286404012849 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1286404012850 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1286404012851 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286404012852 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1286404012853 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1286404012854 CoA-binding site [chemical binding]; other site 1286404012855 ATP-binding [chemical binding]; other site 1286404012856 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1286404012857 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1286404012858 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1286404012859 DNA binding site [nucleotide binding] 1286404012860 catalytic residue [active] 1286404012861 H2TH interface [polypeptide binding]; other site 1286404012862 putative catalytic residues [active] 1286404012863 turnover-facilitating residue; other site 1286404012864 intercalation triad [nucleotide binding]; other site 1286404012865 8OG recognition residue [nucleotide binding]; other site 1286404012866 putative reading head residues; other site 1286404012867 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1286404012868 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1286404012869 DNA polymerase I; Provisional; Region: PRK05755 1286404012870 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1286404012871 active site 1286404012872 metal binding site 1 [ion binding]; metal-binding site 1286404012873 putative 5' ssDNA interaction site; other site 1286404012874 metal binding site 3; metal-binding site 1286404012875 metal binding site 2 [ion binding]; metal-binding site 1286404012876 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1286404012877 putative DNA binding site [nucleotide binding]; other site 1286404012878 putative metal binding site [ion binding]; other site 1286404012879 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1286404012880 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1286404012881 active site 1286404012882 DNA binding site [nucleotide binding] 1286404012883 catalytic site [active] 1286404012884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404012885 dimerization interface [polypeptide binding]; other site 1286404012886 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1286404012887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404012888 putative active site [active] 1286404012889 heme pocket [chemical binding]; other site 1286404012890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404012891 dimer interface [polypeptide binding]; other site 1286404012892 phosphorylation site [posttranslational modification] 1286404012893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404012894 ATP binding site [chemical binding]; other site 1286404012895 Mg2+ binding site [ion binding]; other site 1286404012896 G-X-G motif; other site 1286404012897 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404012898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404012899 active site 1286404012900 phosphorylation site [posttranslational modification] 1286404012901 intermolecular recognition site; other site 1286404012902 dimerization interface [polypeptide binding]; other site 1286404012903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404012904 DNA binding site [nucleotide binding] 1286404012905 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1286404012906 active site 2 [active] 1286404012907 active site 1 [active] 1286404012908 malate dehydrogenase; Reviewed; Region: PRK06223 1286404012909 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1286404012910 NAD(P) binding site [chemical binding]; other site 1286404012911 dimer interface [polypeptide binding]; other site 1286404012912 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404012913 substrate binding site [chemical binding]; other site 1286404012914 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1286404012915 isocitrate dehydrogenase; Validated; Region: PRK07362 1286404012916 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1286404012917 dimer interface [polypeptide binding]; other site 1286404012918 Citrate synthase; Region: Citrate_synt; pfam00285 1286404012919 active site 1286404012920 citrylCoA binding site [chemical binding]; other site 1286404012921 oxalacetate/citrate binding site [chemical binding]; other site 1286404012922 coenzyme A binding site [chemical binding]; other site 1286404012923 catalytic triad [active] 1286404012924 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1286404012925 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1286404012926 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1286404012927 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1286404012928 pyruvate kinase; Provisional; Region: PRK06354 1286404012929 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1286404012930 domain interfaces; other site 1286404012931 active site 1286404012932 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1286404012933 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1286404012934 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1286404012935 active site 1286404012936 ADP/pyrophosphate binding site [chemical binding]; other site 1286404012937 dimerization interface [polypeptide binding]; other site 1286404012938 allosteric effector site; other site 1286404012939 fructose-1,6-bisphosphate binding site; other site 1286404012940 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1286404012941 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1286404012942 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1286404012943 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1286404012944 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1286404012945 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286404012946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404012947 DNA-binding site [nucleotide binding]; DNA binding site 1286404012948 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1286404012949 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1286404012950 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1286404012951 putative NAD(P) binding site [chemical binding]; other site 1286404012952 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1286404012953 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1286404012954 active site 1286404012955 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1286404012956 generic binding surface II; other site 1286404012957 generic binding surface I; other site 1286404012958 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1286404012959 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1286404012960 DHH family; Region: DHH; pfam01368 1286404012961 DHHA1 domain; Region: DHHA1; pfam02272 1286404012962 YtpI-like protein; Region: YtpI; pfam14007 1286404012963 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 1286404012964 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1286404012965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404012966 DNA-binding site [nucleotide binding]; DNA binding site 1286404012967 DRTGG domain; Region: DRTGG; pfam07085 1286404012968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1286404012969 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1286404012970 active site 2 [active] 1286404012971 active site 1 [active] 1286404012972 metal-dependent hydrolase; Provisional; Region: PRK00685 1286404012973 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1286404012974 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1286404012975 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1286404012976 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1286404012977 active site 1286404012978 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1286404012979 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1286404012980 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1286404012981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404012982 Coenzyme A binding pocket [chemical binding]; other site 1286404012983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404012984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404012985 Coenzyme A binding pocket [chemical binding]; other site 1286404012986 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1286404012987 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1286404012988 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1286404012989 hexamer interface [polypeptide binding]; other site 1286404012990 ligand binding site [chemical binding]; other site 1286404012991 putative active site [active] 1286404012992 NAD(P) binding site [chemical binding]; other site 1286404012993 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1286404012994 classical (c) SDRs; Region: SDR_c; cd05233 1286404012995 NAD(P) binding site [chemical binding]; other site 1286404012996 active site 1286404012997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1286404012998 Ligand Binding Site [chemical binding]; other site 1286404012999 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1286404013000 argininosuccinate lyase; Provisional; Region: PRK00855 1286404013001 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1286404013002 active sites [active] 1286404013003 tetramer interface [polypeptide binding]; other site 1286404013004 argininosuccinate synthase; Provisional; Region: PRK13820 1286404013005 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1286404013006 ANP binding site [chemical binding]; other site 1286404013007 Substrate Binding Site II [chemical binding]; other site 1286404013008 Substrate Binding Site I [chemical binding]; other site 1286404013009 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404013010 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404013011 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404013012 EcsC protein family; Region: EcsC; pfam12787 1286404013013 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1286404013014 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1286404013015 nudix motif; other site 1286404013016 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1286404013017 propionate/acetate kinase; Provisional; Region: PRK12379 1286404013018 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1286404013019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404013020 S-adenosylmethionine binding site [chemical binding]; other site 1286404013021 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1286404013022 dimer interface [polypeptide binding]; other site 1286404013023 catalytic triad [active] 1286404013024 peroxidatic and resolving cysteines [active] 1286404013025 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1286404013026 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1286404013027 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1286404013028 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1286404013029 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1286404013030 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1286404013031 active site 1286404013032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404013033 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1286404013034 dimer interface [polypeptide binding]; other site 1286404013035 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1286404013036 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1286404013037 active site 1286404013038 acyl-activating enzyme (AAE) consensus motif; other site 1286404013039 putative CoA binding site [chemical binding]; other site 1286404013040 AMP binding site [chemical binding]; other site 1286404013041 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404013042 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1286404013043 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1286404013044 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1286404013045 Ligand Binding Site [chemical binding]; other site 1286404013046 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1286404013047 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1286404013048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404013049 catalytic residue [active] 1286404013050 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1286404013051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404013052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404013053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404013054 dimerization interface [polypeptide binding]; other site 1286404013055 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404013056 EamA-like transporter family; Region: EamA; pfam00892 1286404013057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404013058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404013059 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1286404013060 GAF domain; Region: GAF_2; pfam13185 1286404013061 methionine gamma-lyase; Provisional; Region: PRK06767 1286404013062 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286404013063 homodimer interface [polypeptide binding]; other site 1286404013064 substrate-cofactor binding pocket; other site 1286404013065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404013066 catalytic residue [active] 1286404013067 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1286404013068 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1286404013069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404013070 RNA binding surface [nucleotide binding]; other site 1286404013071 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1286404013072 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1286404013073 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1286404013074 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1286404013075 active site 1286404013076 HIGH motif; other site 1286404013077 dimer interface [polypeptide binding]; other site 1286404013078 KMSKS motif; other site 1286404013079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404013080 RNA binding surface [nucleotide binding]; other site 1286404013081 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1286404013082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404013083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404013084 DNA binding residues [nucleotide binding] 1286404013085 maltose O-acetyltransferase; Provisional; Region: PRK10092 1286404013086 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1286404013087 active site 1286404013088 substrate binding site [chemical binding]; other site 1286404013089 trimer interface [polypeptide binding]; other site 1286404013090 CoA binding site [chemical binding]; other site 1286404013091 acetyl-CoA synthetase; Provisional; Region: PRK04319 1286404013092 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1286404013093 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1286404013094 active site 1286404013095 acyl-activating enzyme (AAE) consensus motif; other site 1286404013096 putative CoA binding site [chemical binding]; other site 1286404013097 AMP binding site [chemical binding]; other site 1286404013098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404013099 Coenzyme A binding pocket [chemical binding]; other site 1286404013100 FOG: CBS domain [General function prediction only]; Region: COG0517 1286404013101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1286404013102 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1286404013103 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1286404013104 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1286404013105 active site 1286404013106 Zn binding site [ion binding]; other site 1286404013107 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1286404013108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404013109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404013110 active site 1286404013111 phosphorylation site [posttranslational modification] 1286404013112 intermolecular recognition site; other site 1286404013113 dimerization interface [polypeptide binding]; other site 1286404013114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404013115 DNA binding site [nucleotide binding] 1286404013116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404013117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404013118 dimerization interface [polypeptide binding]; other site 1286404013119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404013120 dimer interface [polypeptide binding]; other site 1286404013121 phosphorylation site [posttranslational modification] 1286404013122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404013123 ATP binding site [chemical binding]; other site 1286404013124 Mg2+ binding site [ion binding]; other site 1286404013125 G-X-G motif; other site 1286404013126 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1286404013127 Ankyrin repeat; Region: Ank; pfam00023 1286404013128 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1286404013129 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1286404013130 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1286404013131 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286404013132 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286404013133 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1286404013134 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1286404013135 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 1286404013136 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 1286404013137 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 1286404013138 catabolite control protein A; Region: ccpA; TIGR01481 1286404013139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404013140 DNA binding site [nucleotide binding] 1286404013141 domain linker motif; other site 1286404013142 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1286404013143 dimerization interface [polypeptide binding]; other site 1286404013144 effector binding site; other site 1286404013145 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1286404013146 Chorismate mutase type II; Region: CM_2; cl00693 1286404013147 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1286404013148 putative dimer interface [polypeptide binding]; other site 1286404013149 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1286404013150 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1286404013151 putative dimer interface [polypeptide binding]; other site 1286404013152 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1286404013153 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1286404013154 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1286404013155 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1286404013156 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1286404013157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404013158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404013159 Coenzyme A binding pocket [chemical binding]; other site 1286404013160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404013161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404013162 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404013163 EamA-like transporter family; Region: EamA; pfam00892 1286404013164 EamA-like transporter family; Region: EamA; pfam00892 1286404013165 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1286404013166 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404013167 DNA binding residues [nucleotide binding] 1286404013168 putative dimer interface [polypeptide binding]; other site 1286404013169 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1286404013170 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1286404013171 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1286404013172 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1286404013173 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 1286404013174 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 1286404013175 active site 1286404013176 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1286404013177 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404013178 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286404013179 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1286404013180 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1286404013181 active site 1286404013182 metal binding site [ion binding]; metal-binding site 1286404013183 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1286404013184 putative tRNA-binding site [nucleotide binding]; other site 1286404013185 hypothetical protein; Provisional; Region: PRK13668 1286404013186 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404013187 catalytic residues [active] 1286404013188 NTPase; Reviewed; Region: PRK03114 1286404013189 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1286404013190 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1286404013191 oligomer interface [polypeptide binding]; other site 1286404013192 active site 1286404013193 metal binding site [ion binding]; metal-binding site 1286404013194 Predicted small secreted protein [Function unknown]; Region: COG5584 1286404013195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404013196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404013197 S-adenosylmethionine binding site [chemical binding]; other site 1286404013198 YtzH-like protein; Region: YtzH; pfam14165 1286404013199 Phosphotransferase enzyme family; Region: APH; pfam01636 1286404013200 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286404013201 active site 1286404013202 substrate binding site [chemical binding]; other site 1286404013203 ATP binding site [chemical binding]; other site 1286404013204 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1286404013205 pullulanase, type I; Region: pulA_typeI; TIGR02104 1286404013206 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1286404013207 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1286404013208 Ca binding site [ion binding]; other site 1286404013209 active site 1286404013210 catalytic site [active] 1286404013211 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1286404013212 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286404013213 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1286404013214 dipeptidase PepV; Reviewed; Region: PRK07318 1286404013215 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1286404013216 active site 1286404013217 metal binding site [ion binding]; metal-binding site 1286404013218 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1286404013219 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1286404013220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404013221 RNA binding surface [nucleotide binding]; other site 1286404013222 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1286404013223 active site 1286404013224 uracil binding [chemical binding]; other site 1286404013225 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1286404013226 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1286404013227 HI0933-like protein; Region: HI0933_like; pfam03486 1286404013228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404013229 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1286404013230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404013231 putative substrate translocation pore; other site 1286404013232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404013233 dimerization interface [polypeptide binding]; other site 1286404013234 putative DNA binding site [nucleotide binding]; other site 1286404013235 putative Zn2+ binding site [ion binding]; other site 1286404013236 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1286404013237 putative hydrophobic ligand binding site [chemical binding]; other site 1286404013238 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 1286404013239 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1286404013240 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1286404013241 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1286404013242 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1286404013243 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1286404013244 NAD binding site [chemical binding]; other site 1286404013245 homodimer interface [polypeptide binding]; other site 1286404013246 active site 1286404013247 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1286404013248 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1286404013249 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1286404013250 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1286404013251 MoaE interaction surface [polypeptide binding]; other site 1286404013252 MoeB interaction surface [polypeptide binding]; other site 1286404013253 thiocarboxylated glycine; other site 1286404013254 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1286404013255 MoaE homodimer interface [polypeptide binding]; other site 1286404013256 MoaD interaction [polypeptide binding]; other site 1286404013257 active site residues [active] 1286404013258 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1286404013259 Walker A motif; other site 1286404013260 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1286404013261 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1286404013262 dimer interface [polypeptide binding]; other site 1286404013263 putative functional site; other site 1286404013264 putative MPT binding site; other site 1286404013265 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1286404013266 trimer interface [polypeptide binding]; other site 1286404013267 dimer interface [polypeptide binding]; other site 1286404013268 putative active site [active] 1286404013269 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1286404013270 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1286404013271 ATP binding site [chemical binding]; other site 1286404013272 substrate interface [chemical binding]; other site 1286404013273 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1286404013274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404013275 FeS/SAM binding site; other site 1286404013276 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1286404013277 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1286404013278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404013279 active site residue [active] 1286404013280 homoserine O-acetyltransferase; Provisional; Region: PRK06765 1286404013281 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286404013282 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1286404013283 Spore germination protein; Region: Spore_permease; pfam03845 1286404013284 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1286404013285 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1286404013286 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1286404013287 putative nucleotide binding site [chemical binding]; other site 1286404013288 putative metal binding site [ion binding]; other site 1286404013289 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1286404013290 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1286404013291 HIGH motif; other site 1286404013292 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1286404013293 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1286404013294 active site 1286404013295 KMSKS motif; other site 1286404013296 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1286404013297 tRNA binding surface [nucleotide binding]; other site 1286404013298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404013299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404013300 putative substrate translocation pore; other site 1286404013301 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404013302 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404013303 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1286404013304 TrkA-C domain; Region: TrkA_C; pfam02080 1286404013305 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1286404013306 Int/Topo IB signature motif; other site 1286404013307 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404013308 FtsX-like permease family; Region: FtsX; pfam02687 1286404013309 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404013310 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404013311 Walker A/P-loop; other site 1286404013312 ATP binding site [chemical binding]; other site 1286404013313 Q-loop/lid; other site 1286404013314 ABC transporter signature motif; other site 1286404013315 Walker B; other site 1286404013316 D-loop; other site 1286404013317 H-loop/switch region; other site 1286404013318 Predicted membrane protein [Function unknown]; Region: COG2311 1286404013319 Protein of unknown function (DUF418); Region: DUF418; cl12135 1286404013320 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1286404013321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404013322 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404013323 Probable transposase; Region: OrfB_IS605; pfam01385 1286404013324 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404013325 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1286404013326 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1286404013327 catalytic residues [active] 1286404013328 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1286404013329 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1286404013330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404013331 FeS/SAM binding site; other site 1286404013332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404013333 S-adenosylmethionine binding site [chemical binding]; other site 1286404013334 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1286404013335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404013336 Walker A/P-loop; other site 1286404013337 ATP binding site [chemical binding]; other site 1286404013338 Q-loop/lid; other site 1286404013339 ABC transporter signature motif; other site 1286404013340 Walker B; other site 1286404013341 D-loop; other site 1286404013342 H-loop/switch region; other site 1286404013343 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1286404013344 aspartate racemase; Region: asp_race; TIGR00035 1286404013345 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1286404013346 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1286404013347 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1286404013348 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1286404013349 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404013350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404013351 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286404013352 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1286404013353 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1286404013354 trimer interface [polypeptide binding]; other site 1286404013355 putative metal binding site [ion binding]; other site 1286404013356 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1286404013357 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1286404013358 active site 1286404013359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404013360 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1286404013361 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1286404013362 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1286404013363 GTP binding site; other site 1286404013364 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1286404013365 MPT binding site; other site 1286404013366 trimer interface [polypeptide binding]; other site 1286404013367 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1286404013368 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1286404013369 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1286404013370 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1286404013371 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1286404013372 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1286404013373 active site 1286404013374 substrate-binding site [chemical binding]; other site 1286404013375 metal-binding site [ion binding] 1286404013376 ATP binding site [chemical binding]; other site 1286404013377 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1286404013378 EamA-like transporter family; Region: EamA; pfam00892 1286404013379 EamA-like transporter family; Region: EamA; pfam00892 1286404013380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1286404013381 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1286404013382 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1286404013383 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1286404013384 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1286404013385 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1286404013386 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1286404013387 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1286404013388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404013389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404013390 ATP binding site [chemical binding]; other site 1286404013391 Mg2+ binding site [ion binding]; other site 1286404013392 G-X-G motif; other site 1286404013393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404013394 dimer interface [polypeptide binding]; other site 1286404013395 phosphorylation site [posttranslational modification] 1286404013396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404013397 ATP binding site [chemical binding]; other site 1286404013398 Mg2+ binding site [ion binding]; other site 1286404013399 G-X-G motif; other site 1286404013400 hydroperoxidase II; Provisional; Region: katE; PRK11249 1286404013401 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1286404013402 heme binding pocket [chemical binding]; other site 1286404013403 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1286404013404 domain interactions; other site 1286404013405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404013406 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1286404013407 TAP-like protein; Region: Abhydrolase_4; pfam08386 1286404013408 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1286404013409 TM-ABC transporter signature motif; other site 1286404013410 Sulfatase; Region: Sulfatase; pfam00884 1286404013411 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1286404013412 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 1286404013413 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1286404013414 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1286404013415 NMT1-like family; Region: NMT1_2; pfam13379 1286404013416 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1286404013417 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1286404013418 Walker A/P-loop; other site 1286404013419 ATP binding site [chemical binding]; other site 1286404013420 Q-loop/lid; other site 1286404013421 ABC transporter signature motif; other site 1286404013422 Walker B; other site 1286404013423 D-loop; other site 1286404013424 H-loop/switch region; other site 1286404013425 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1286404013426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404013427 dimer interface [polypeptide binding]; other site 1286404013428 conserved gate region; other site 1286404013429 putative PBP binding loops; other site 1286404013430 ABC-ATPase subunit interface; other site 1286404013431 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1286404013432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404013433 motif II; other site 1286404013434 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1286404013435 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1286404013436 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1286404013437 nudix motif; other site 1286404013438 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 1286404013439 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1286404013440 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404013441 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1286404013442 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1286404013443 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404013444 DNA binding residues [nucleotide binding] 1286404013445 dimer interface [polypeptide binding]; other site 1286404013446 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286404013447 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1286404013448 Haemolytic domain; Region: Haemolytic; pfam01809 1286404013449 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1286404013450 active site clefts [active] 1286404013451 zinc binding site [ion binding]; other site 1286404013452 dimer interface [polypeptide binding]; other site 1286404013453 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1286404013454 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1286404013455 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1286404013456 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1286404013457 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1286404013458 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1286404013459 putative active site [active] 1286404013460 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404013461 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404013462 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404013463 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404013464 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1286404013465 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1286404013466 Predicted membrane protein [Function unknown]; Region: COG3766 1286404013467 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1286404013468 hypothetical protein; Provisional; Region: PRK12473 1286404013469 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1286404013470 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1286404013471 G1 box; other site 1286404013472 GTP/Mg2+ binding site [chemical binding]; other site 1286404013473 Switch I region; other site 1286404013474 G2 box; other site 1286404013475 G3 box; other site 1286404013476 Switch II region; other site 1286404013477 G4 box; other site 1286404013478 G5 box; other site 1286404013479 Nucleoside recognition; Region: Gate; pfam07670 1286404013480 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1286404013481 Nucleoside recognition; Region: Gate; pfam07670 1286404013482 FeoA domain; Region: FeoA; pfam04023 1286404013483 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1286404013484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404013485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404013486 dimerization interface [polypeptide binding]; other site 1286404013487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404013488 dimer interface [polypeptide binding]; other site 1286404013489 phosphorylation site [posttranslational modification] 1286404013490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404013491 ATP binding site [chemical binding]; other site 1286404013492 Mg2+ binding site [ion binding]; other site 1286404013493 G-X-G motif; other site 1286404013494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404013495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404013496 active site 1286404013497 phosphorylation site [posttranslational modification] 1286404013498 intermolecular recognition site; other site 1286404013499 dimerization interface [polypeptide binding]; other site 1286404013500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404013501 DNA binding site [nucleotide binding] 1286404013502 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1286404013503 active site 1286404013504 catalytic site [active] 1286404013505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404013506 active site 1286404013507 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1286404013508 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1286404013509 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1286404013510 FtsX-like permease family; Region: FtsX; pfam02687 1286404013511 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404013512 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404013513 Walker A/P-loop; other site 1286404013514 ATP binding site [chemical binding]; other site 1286404013515 Q-loop/lid; other site 1286404013516 ABC transporter signature motif; other site 1286404013517 Walker B; other site 1286404013518 D-loop; other site 1286404013519 H-loop/switch region; other site 1286404013520 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1286404013521 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404013522 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404013523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404013524 S-adenosylmethionine binding site [chemical binding]; other site 1286404013525 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404013526 FtsX-like permease family; Region: FtsX; pfam02687 1286404013527 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404013528 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404013529 Walker A/P-loop; other site 1286404013530 ATP binding site [chemical binding]; other site 1286404013531 Q-loop/lid; other site 1286404013532 ABC transporter signature motif; other site 1286404013533 Walker B; other site 1286404013534 D-loop; other site 1286404013535 H-loop/switch region; other site 1286404013536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1286404013537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1286404013538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1286404013539 SdpI/YhfL protein family; Region: SdpI; pfam13630 1286404013540 Predicted integral membrane protein [Function unknown]; Region: COG5658 1286404013541 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1286404013542 SdpI/YhfL protein family; Region: SdpI; pfam13630 1286404013543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404013544 dimerization interface [polypeptide binding]; other site 1286404013545 putative DNA binding site [nucleotide binding]; other site 1286404013546 putative Zn2+ binding site [ion binding]; other site 1286404013547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404013548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404013549 active site 1286404013550 phosphorylation site [posttranslational modification] 1286404013551 intermolecular recognition site; other site 1286404013552 dimerization interface [polypeptide binding]; other site 1286404013553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404013554 DNA binding site [nucleotide binding] 1286404013555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404013556 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1286404013557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404013558 ATP binding site [chemical binding]; other site 1286404013559 Mg2+ binding site [ion binding]; other site 1286404013560 G-X-G motif; other site 1286404013561 FtsX-like permease family; Region: FtsX; pfam02687 1286404013562 FtsX-like permease family; Region: FtsX; pfam02687 1286404013563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404013564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404013565 Walker A/P-loop; other site 1286404013566 ATP binding site [chemical binding]; other site 1286404013567 Q-loop/lid; other site 1286404013568 ABC transporter signature motif; other site 1286404013569 Walker B; other site 1286404013570 D-loop; other site 1286404013571 H-loop/switch region; other site 1286404013572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404013573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404013574 GntP family permease; Region: GntP_permease; pfam02447 1286404013575 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1286404013576 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1286404013577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404013578 DNA-binding site [nucleotide binding]; DNA binding site 1286404013579 UTRA domain; Region: UTRA; pfam07702 1286404013580 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1286404013581 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1286404013582 substrate binding site [chemical binding]; other site 1286404013583 ATP binding site [chemical binding]; other site 1286404013584 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1286404013585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1286404013586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404013587 catalytic residue [active] 1286404013588 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1286404013589 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1286404013590 active site 1286404013591 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1286404013592 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1286404013593 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1286404013594 dimerization interface [polypeptide binding]; other site 1286404013595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404013596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404013597 dimer interface [polypeptide binding]; other site 1286404013598 phosphorylation site [posttranslational modification] 1286404013599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404013600 ATP binding site [chemical binding]; other site 1286404013601 Mg2+ binding site [ion binding]; other site 1286404013602 G-X-G motif; other site 1286404013603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404013604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404013605 active site 1286404013606 phosphorylation site [posttranslational modification] 1286404013607 intermolecular recognition site; other site 1286404013608 dimerization interface [polypeptide binding]; other site 1286404013609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404013610 DNA binding site [nucleotide binding] 1286404013611 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1286404013612 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1286404013613 active site 1286404013614 octamer interface [polypeptide binding]; other site 1286404013615 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1286404013616 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1286404013617 acyl-activating enzyme (AAE) consensus motif; other site 1286404013618 putative AMP binding site [chemical binding]; other site 1286404013619 putative active site [active] 1286404013620 putative CoA binding site [chemical binding]; other site 1286404013621 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286404013622 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1286404013623 substrate binding site [chemical binding]; other site 1286404013624 oxyanion hole (OAH) forming residues; other site 1286404013625 trimer interface [polypeptide binding]; other site 1286404013626 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1286404013627 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1286404013628 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1286404013629 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1286404013630 dimer interface [polypeptide binding]; other site 1286404013631 tetramer interface [polypeptide binding]; other site 1286404013632 PYR/PP interface [polypeptide binding]; other site 1286404013633 TPP binding site [chemical binding]; other site 1286404013634 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1286404013635 TPP-binding site; other site 1286404013636 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1286404013637 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1286404013638 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1286404013639 UbiA prenyltransferase family; Region: UbiA; pfam01040 1286404013640 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1286404013641 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404013642 DNA-binding site [nucleotide binding]; DNA binding site 1286404013643 RNA-binding motif; other site 1286404013644 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1286404013645 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1286404013646 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404013647 DNA binding residues [nucleotide binding] 1286404013648 dimer interface [polypeptide binding]; other site 1286404013649 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286404013650 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1286404013651 active site flap/lid [active] 1286404013652 nucleophilic elbow; other site 1286404013653 catalytic triad [active] 1286404013654 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1286404013655 homodimer interface [polypeptide binding]; other site 1286404013656 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1286404013657 active site pocket [active] 1286404013658 glycogen synthase; Provisional; Region: glgA; PRK00654 1286404013659 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1286404013660 ADP-binding pocket [chemical binding]; other site 1286404013661 homodimer interface [polypeptide binding]; other site 1286404013662 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1286404013663 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1286404013664 ligand binding site; other site 1286404013665 oligomer interface; other site 1286404013666 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1286404013667 dimer interface [polypeptide binding]; other site 1286404013668 N-terminal domain interface [polypeptide binding]; other site 1286404013669 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1286404013670 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1286404013671 ligand binding site; other site 1286404013672 oligomer interface; other site 1286404013673 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1286404013674 dimer interface [polypeptide binding]; other site 1286404013675 N-terminal domain interface [polypeptide binding]; other site 1286404013676 sulfate 1 binding site; other site 1286404013677 glycogen branching enzyme; Provisional; Region: PRK12313 1286404013678 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1286404013679 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1286404013680 active site 1286404013681 catalytic site [active] 1286404013682 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1286404013683 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1286404013684 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1286404013685 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1286404013686 putative active site [active] 1286404013687 catalytic triad [active] 1286404013688 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1286404013689 PA/protease domain interface [polypeptide binding]; other site 1286404013690 putative integrin binding motif; other site 1286404013691 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1286404013692 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1286404013693 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1286404013694 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1286404013695 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404013696 NAD binding site [chemical binding]; other site 1286404013697 dimer interface [polypeptide binding]; other site 1286404013698 substrate binding site [chemical binding]; other site 1286404013699 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1286404013700 MgtC family; Region: MgtC; pfam02308 1286404013701 Ion channel; Region: Ion_trans_2; pfam07885 1286404013702 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1286404013703 TrkA-N domain; Region: TrkA_N; pfam02254 1286404013704 YugN-like family; Region: YugN; pfam08868 1286404013705 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1286404013706 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1286404013707 active site 1286404013708 dimer interface [polypeptide binding]; other site 1286404013709 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1286404013710 dimer interface [polypeptide binding]; other site 1286404013711 active site 1286404013712 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1286404013713 general stress protein 13; Validated; Region: PRK08059 1286404013714 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286404013715 RNA binding site [nucleotide binding]; other site 1286404013716 hypothetical protein; Validated; Region: PRK07682 1286404013717 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404013718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404013719 homodimer interface [polypeptide binding]; other site 1286404013720 catalytic residue [active] 1286404013721 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286404013722 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404013723 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1286404013724 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1286404013725 dimerization interface [polypeptide binding]; other site 1286404013726 ligand binding site [chemical binding]; other site 1286404013727 NADP binding site [chemical binding]; other site 1286404013728 catalytic site [active] 1286404013729 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1286404013730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404013731 nucleophilic elbow; other site 1286404013732 catalytic triad; other site 1286404013733 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1286404013734 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1286404013735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404013736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404013737 homodimer interface [polypeptide binding]; other site 1286404013738 catalytic residue [active] 1286404013739 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1286404013740 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1286404013741 E-class dimer interface [polypeptide binding]; other site 1286404013742 P-class dimer interface [polypeptide binding]; other site 1286404013743 active site 1286404013744 Cu2+ binding site [ion binding]; other site 1286404013745 Zn2+ binding site [ion binding]; other site 1286404013746 Kinase associated protein B; Region: KapB; pfam08810 1286404013747 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1286404013748 active site 1286404013749 catalytic site [active] 1286404013750 substrate binding site [chemical binding]; other site 1286404013751 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1286404013752 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1286404013753 transmembrane helices; other site 1286404013754 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1286404013755 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1286404013756 active site 1286404013757 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1286404013758 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1286404013759 motif 1; other site 1286404013760 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1286404013761 active site 1286404013762 motif 2; other site 1286404013763 motif 3; other site 1286404013764 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1286404013765 anticodon binding site; other site 1286404013766 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286404013767 CoenzymeA binding site [chemical binding]; other site 1286404013768 subunit interaction site [polypeptide binding]; other site 1286404013769 PHB binding site; other site 1286404013770 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1286404013771 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1286404013772 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1286404013773 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1286404013774 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286404013775 active site 1286404013776 tetramer interface; other site 1286404013777 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1286404013778 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1286404013779 active site 1286404013780 substrate binding site [chemical binding]; other site 1286404013781 metal binding site [ion binding]; metal-binding site 1286404013782 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1286404013783 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1286404013784 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1286404013785 Divergent PAP2 family; Region: DUF212; cl00855 1286404013786 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1286404013787 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1286404013788 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1286404013789 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1286404013790 interface (dimer of trimers) [polypeptide binding]; other site 1286404013791 Substrate-binding/catalytic site; other site 1286404013792 Zn-binding sites [ion binding]; other site 1286404013793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1286404013794 Putative membrane protein; Region: YuiB; pfam14068 1286404013795 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1286404013796 nudix motif; other site 1286404013797 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286404013798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404013799 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1286404013800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404013801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404013802 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013803 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013804 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013805 Domain of unknown function DUF11; Region: DUF11; pfam01345 1286404013806 Domain of unknown function DUF11; Region: DUF11; pfam01345 1286404013807 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404013808 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404013809 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404013810 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404013811 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013812 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013813 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013814 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013815 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1286404013816 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1286404013817 Domain of unknown function DUF11; Region: DUF11; cl17728 1286404013818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1286404013819 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404013820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404013821 putative substrate translocation pore; other site 1286404013822 Helix-turn-helix domain; Region: HTH_36; pfam13730 1286404013823 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1286404013824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1286404013825 putative DNA binding site [nucleotide binding]; other site 1286404013826 dimerization interface [polypeptide binding]; other site 1286404013827 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1286404013828 Helix-turn-helix domain; Region: HTH_36; pfam13730 1286404013829 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404013830 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1286404013831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404013832 non-specific DNA binding site [nucleotide binding]; other site 1286404013833 salt bridge; other site 1286404013834 sequence-specific DNA binding site [nucleotide binding]; other site 1286404013835 hypothetical protein; Region: PHA02436 1286404013836 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404013837 amidase catalytic site [active] 1286404013838 Zn binding residues [ion binding]; other site 1286404013839 substrate binding site [chemical binding]; other site 1286404013840 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404013841 Holin family; Region: Phage_holin_4; pfam05105 1286404013842 Haemolysin XhlA; Region: XhlA; pfam10779 1286404013843 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1286404013844 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1286404013845 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1286404013846 Phage tail protein; Region: Sipho_tail; cl17486 1286404013847 Phage-related minor tail protein [Function unknown]; Region: COG5280 1286404013848 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1286404013849 membrane protein P6; Region: PHA01399 1286404013850 Phage-related protein [Function unknown]; Region: COG5412 1286404013851 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1286404013852 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1286404013853 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 1286404013854 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1286404013855 Phage capsid family; Region: Phage_capsid; pfam05065 1286404013856 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1286404013857 Phage portal protein; Region: Phage_portal; pfam04860 1286404013858 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1286404013859 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1286404013860 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1286404013861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404013862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404013863 Walker A motif; other site 1286404013864 ATP binding site [chemical binding]; other site 1286404013865 Walker B motif; other site 1286404013866 arginine finger; other site 1286404013867 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1286404013868 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1286404013869 ORF6C domain; Region: ORF6C; pfam10552 1286404013870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404013871 sequence-specific DNA binding site [nucleotide binding]; other site 1286404013872 salt bridge; other site 1286404013873 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404013874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404013875 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404013876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404013877 non-specific DNA binding site [nucleotide binding]; other site 1286404013878 salt bridge; other site 1286404013879 sequence-specific DNA binding site [nucleotide binding]; other site 1286404013880 integrase; Provisional; Region: int; PHA02601 1286404013881 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1286404013882 Int/Topo IB signature motif; other site 1286404013883 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1286404013884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1286404013885 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404013886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404013887 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1286404013888 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1286404013889 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286404013890 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1286404013891 hypothetical protein; Provisional; Region: PRK13669 1286404013892 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286404013893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404013894 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404013895 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404013896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404013897 Walker A/P-loop; other site 1286404013898 ATP binding site [chemical binding]; other site 1286404013899 Q-loop/lid; other site 1286404013900 ABC transporter signature motif; other site 1286404013901 Walker B; other site 1286404013902 D-loop; other site 1286404013903 H-loop/switch region; other site 1286404013904 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1286404013905 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1286404013906 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1286404013907 PhnA protein; Region: PhnA; pfam03831 1286404013908 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1286404013909 CAAX protease self-immunity; Region: Abi; pfam02517 1286404013910 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286404013911 active site 1286404013912 NTP binding site [chemical binding]; other site 1286404013913 metal binding triad [ion binding]; metal-binding site 1286404013914 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1286404013915 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1286404013916 NifU-like domain; Region: NifU; pfam01106 1286404013917 spore coat protein YutH; Region: spore_yutH; TIGR02905 1286404013918 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1286404013919 tetramer interfaces [polypeptide binding]; other site 1286404013920 binuclear metal-binding site [ion binding]; other site 1286404013921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404013922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404013923 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1286404013924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404013925 active site 1286404013926 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1286404013927 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1286404013928 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1286404013929 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1286404013930 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404013931 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1286404013932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404013933 active site 1286404013934 motif I; other site 1286404013935 motif II; other site 1286404013936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404013937 Predicted transcriptional regulator [Transcription]; Region: COG2345 1286404013938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404013939 putative Zn2+ binding site [ion binding]; other site 1286404013940 putative DNA binding site [nucleotide binding]; other site 1286404013941 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1286404013942 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1286404013943 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1286404013944 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1286404013945 putative active site [active] 1286404013946 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1286404013947 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1286404013948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404013949 RNA binding surface [nucleotide binding]; other site 1286404013950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404013951 Coenzyme A binding pocket [chemical binding]; other site 1286404013952 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1286404013953 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1286404013954 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404013955 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1286404013956 DNA binding residues [nucleotide binding] 1286404013957 dimer interface [polypeptide binding]; other site 1286404013958 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286404013959 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1286404013960 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404013961 catalytic core [active] 1286404013962 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1286404013963 putative deacylase active site [active] 1286404013964 lipoyl synthase; Provisional; Region: PRK05481 1286404013965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404013966 FeS/SAM binding site; other site 1286404013967 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404013968 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404013969 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1286404013970 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1286404013971 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1286404013972 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1286404013973 active site 1286404013974 metal binding site [ion binding]; metal-binding site 1286404013975 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1286404013976 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1286404013977 FeS assembly protein SufB; Region: sufB; TIGR01980 1286404013978 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1286404013979 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1286404013980 trimerization site [polypeptide binding]; other site 1286404013981 active site 1286404013982 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1286404013983 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1286404013984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404013985 catalytic residue [active] 1286404013986 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1286404013987 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1286404013988 FeS assembly protein SufD; Region: sufD; TIGR01981 1286404013989 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1286404013990 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1286404013991 Walker A/P-loop; other site 1286404013992 ATP binding site [chemical binding]; other site 1286404013993 Q-loop/lid; other site 1286404013994 ABC transporter signature motif; other site 1286404013995 Walker B; other site 1286404013996 D-loop; other site 1286404013997 H-loop/switch region; other site 1286404013998 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286404013999 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286404014000 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1286404014001 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1286404014002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1286404014003 ABC-ATPase subunit interface; other site 1286404014004 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1286404014005 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1286404014006 Walker A/P-loop; other site 1286404014007 ATP binding site [chemical binding]; other site 1286404014008 Q-loop/lid; other site 1286404014009 ABC transporter signature motif; other site 1286404014010 Walker B; other site 1286404014011 D-loop; other site 1286404014012 H-loop/switch region; other site 1286404014013 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1286404014014 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404014015 catalytic residues [active] 1286404014016 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1286404014017 putative active site [active] 1286404014018 putative metal binding site [ion binding]; other site 1286404014019 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1286404014020 lipoyl attachment site [posttranslational modification]; other site 1286404014021 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1286404014022 ArsC family; Region: ArsC; pfam03960 1286404014023 putative ArsC-like catalytic residues; other site 1286404014024 putative TRX-like catalytic residues [active] 1286404014025 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1286404014026 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1286404014027 active site 1286404014028 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1286404014029 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1286404014030 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404014031 NAD binding site [chemical binding]; other site 1286404014032 dimer interface [polypeptide binding]; other site 1286404014033 substrate binding site [chemical binding]; other site 1286404014034 Coat F domain; Region: Coat_F; pfam07875 1286404014035 CAAX protease self-immunity; Region: Abi; pfam02517 1286404014036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404014037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404014038 WHG domain; Region: WHG; pfam13305 1286404014039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1286404014040 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286404014041 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404014042 active site 1286404014043 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1286404014044 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286404014045 dimer interface [polypeptide binding]; other site 1286404014046 active site 1286404014047 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1286404014048 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286404014049 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286404014050 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286404014051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1286404014052 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1286404014053 substrate binding site [chemical binding]; other site 1286404014054 oxyanion hole (OAH) forming residues; other site 1286404014055 YuzL-like protein; Region: YuzL; pfam14115 1286404014056 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404014057 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286404014058 Proline dehydrogenase; Region: Pro_dh; cl03282 1286404014059 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1286404014060 Domain of unknown function DUF77; Region: DUF77; pfam01910 1286404014061 Cache domain; Region: Cache_1; pfam02743 1286404014062 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404014063 dimerization interface [polypeptide binding]; other site 1286404014064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404014065 dimer interface [polypeptide binding]; other site 1286404014066 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404014067 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404014068 dimer interface [polypeptide binding]; other site 1286404014069 putative CheW interface [polypeptide binding]; other site 1286404014070 Predicted transcriptional regulators [Transcription]; Region: COG1378 1286404014071 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1286404014072 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1286404014073 C-terminal domain interface [polypeptide binding]; other site 1286404014074 sugar binding site [chemical binding]; other site 1286404014075 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404014076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404014077 putative substrate translocation pore; other site 1286404014078 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1286404014079 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1286404014080 OxaA-like protein precursor; Validated; Region: PRK01622 1286404014081 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404014082 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404014083 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404014084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404014085 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404014086 hypothetical protein; Provisional; Region: PRK06758 1286404014087 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1286404014088 active site 1286404014089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404014090 non-specific DNA binding site [nucleotide binding]; other site 1286404014091 salt bridge; other site 1286404014092 sequence-specific DNA binding site [nucleotide binding]; other site 1286404014093 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404014094 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404014095 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 1286404014096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1286404014097 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1286404014098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404014099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404014100 active site 1286404014101 phosphorylation site [posttranslational modification] 1286404014102 intermolecular recognition site; other site 1286404014103 dimerization interface [polypeptide binding]; other site 1286404014104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404014105 DNA binding site [nucleotide binding] 1286404014106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404014107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404014108 dimer interface [polypeptide binding]; other site 1286404014109 phosphorylation site [posttranslational modification] 1286404014110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404014111 ATP binding site [chemical binding]; other site 1286404014112 Mg2+ binding site [ion binding]; other site 1286404014113 G-X-G motif; other site 1286404014114 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404014115 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1286404014116 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1286404014117 active site 1286404014118 HIGH motif; other site 1286404014119 KMSKS motif; other site 1286404014120 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1286404014121 tRNA binding surface [nucleotide binding]; other site 1286404014122 anticodon binding site; other site 1286404014123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404014124 S-adenosylmethionine binding site [chemical binding]; other site 1286404014125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404014126 dimerization interface [polypeptide binding]; other site 1286404014127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404014128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404014129 dimer interface [polypeptide binding]; other site 1286404014130 putative CheW interface [polypeptide binding]; other site 1286404014131 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1286404014132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404014133 dimerization interface [polypeptide binding]; other site 1286404014134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404014135 dimer interface [polypeptide binding]; other site 1286404014136 putative CheW interface [polypeptide binding]; other site 1286404014137 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1286404014138 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404014139 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404014140 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1286404014141 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404014142 active site 1286404014143 Zn binding site [ion binding]; other site 1286404014144 Pirin-related protein [General function prediction only]; Region: COG1741 1286404014145 Pirin; Region: Pirin; pfam02678 1286404014146 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1286404014147 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1286404014148 MarR family; Region: MarR_2; pfam12802 1286404014149 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 1286404014150 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1286404014151 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1286404014152 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404014153 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404014154 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1286404014155 TrkA-C domain; Region: TrkA_C; pfam02080 1286404014156 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404014157 amino acid carrier protein; Region: agcS; TIGR00835 1286404014158 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1286404014159 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1286404014160 dimerization interface [polypeptide binding]; other site 1286404014161 DPS ferroxidase diiron center [ion binding]; other site 1286404014162 ion pore; other site 1286404014163 DinB family; Region: DinB; cl17821 1286404014164 DinB superfamily; Region: DinB_2; pfam12867 1286404014165 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1286404014166 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1286404014167 metal binding site [ion binding]; metal-binding site 1286404014168 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1286404014169 Ferritin-like domain; Region: Ferritin; pfam00210 1286404014170 ferroxidase diiron center [ion binding]; other site 1286404014171 Predicted membrane protein [Function unknown]; Region: COG2311 1286404014172 Protein of unknown function (DUF418); Region: DUF418; cl12135 1286404014173 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1286404014174 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404014175 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404014176 Nucleoside recognition; Region: Gate; pfam07670 1286404014177 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404014178 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404014179 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404014180 Nucleoside recognition; Region: Gate; pfam07670 1286404014181 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404014182 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404014183 amino acid carrier protein; Region: agcS; TIGR00835 1286404014184 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1286404014185 amino acid carrier protein; Region: agcS; TIGR00835 1286404014186 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1286404014187 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1286404014188 NAD binding site [chemical binding]; other site 1286404014189 substrate binding site [chemical binding]; other site 1286404014190 putative active site [active] 1286404014191 Peptidase M60-like family; Region: M60-like; pfam13402 1286404014192 Viral enhancin protein; Region: Enhancin; pfam03272 1286404014193 TQXA domain; Region: TQXA_dom; TIGR03934 1286404014194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1286404014195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1286404014196 active site 1286404014197 catalytic tetrad [active] 1286404014198 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404014199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404014200 putative substrate translocation pore; other site 1286404014201 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404014202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404014203 dimerization interface [polypeptide binding]; other site 1286404014204 putative DNA binding site [nucleotide binding]; other site 1286404014205 putative Zn2+ binding site [ion binding]; other site 1286404014206 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1286404014207 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1286404014208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404014209 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1286404014210 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1286404014211 active site 1286404014212 HIGH motif; other site 1286404014213 dimer interface [polypeptide binding]; other site 1286404014214 KMSKS motif; other site 1286404014215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1286404014216 RNA binding surface [nucleotide binding]; other site 1286404014217 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 1286404014218 FAD binding domain; Region: FAD_binding_4; pfam01565 1286404014219 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1286404014220 SET domain; Region: SET; pfam00856 1286404014221 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 1286404014222 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404014223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404014224 dimer interface [polypeptide binding]; other site 1286404014225 putative CheW interface [polypeptide binding]; other site 1286404014226 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1286404014227 putative phosphate binding site [ion binding]; other site 1286404014228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1286404014229 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1286404014230 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1286404014231 camphor resistance protein CrcB; Provisional; Region: PRK14219 1286404014232 camphor resistance protein CrcB; Provisional; Region: PRK14205 1286404014233 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 1286404014234 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1286404014235 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404014236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404014237 Coenzyme A binding pocket [chemical binding]; other site 1286404014238 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1286404014239 Nuclease-related domain; Region: NERD; pfam08378 1286404014240 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1286404014241 Isochorismatase family; Region: Isochorismatase; pfam00857 1286404014242 catalytic triad [active] 1286404014243 conserved cis-peptide bond; other site 1286404014244 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1286404014245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404014246 putative DNA binding site [nucleotide binding]; other site 1286404014247 putative Zn2+ binding site [ion binding]; other site 1286404014248 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404014249 MarR family; Region: MarR_2; pfam12802 1286404014250 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1286404014251 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1286404014252 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286404014253 Walker A/P-loop; other site 1286404014254 ATP binding site [chemical binding]; other site 1286404014255 Q-loop/lid; other site 1286404014256 ABC transporter signature motif; other site 1286404014257 Walker B; other site 1286404014258 D-loop; other site 1286404014259 H-loop/switch region; other site 1286404014260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404014261 ABC-ATPase subunit interface; other site 1286404014262 dimer interface [polypeptide binding]; other site 1286404014263 putative PBP binding regions; other site 1286404014264 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404014265 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404014266 ABC-ATPase subunit interface; other site 1286404014267 dimer interface [polypeptide binding]; other site 1286404014268 putative PBP binding regions; other site 1286404014269 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1286404014270 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1286404014271 putative ligand binding residues [chemical binding]; other site 1286404014272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404014273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404014274 active site 1286404014275 phosphorylation site [posttranslational modification] 1286404014276 intermolecular recognition site; other site 1286404014277 dimerization interface [polypeptide binding]; other site 1286404014278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404014279 DNA binding site [nucleotide binding] 1286404014280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1286404014281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404014282 Coenzyme A binding pocket [chemical binding]; other site 1286404014283 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1286404014284 SmpB-tmRNA interface; other site 1286404014285 ribonuclease R; Region: RNase_R; TIGR02063 1286404014286 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1286404014287 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1286404014288 RNB domain; Region: RNB; pfam00773 1286404014289 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1286404014290 RNA binding site [nucleotide binding]; other site 1286404014291 Esterase/lipase [General function prediction only]; Region: COG1647 1286404014292 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1286404014293 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1286404014294 holin-like protein; Validated; Region: PRK01658 1286404014295 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1286404014296 active site 1286404014297 enolase; Provisional; Region: eno; PRK00077 1286404014298 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1286404014299 dimer interface [polypeptide binding]; other site 1286404014300 metal binding site [ion binding]; metal-binding site 1286404014301 substrate binding pocket [chemical binding]; other site 1286404014302 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1286404014303 phosphoglyceromutase; Provisional; Region: PRK05434 1286404014304 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1286404014305 triosephosphate isomerase; Provisional; Region: PRK14565 1286404014306 substrate binding site [chemical binding]; other site 1286404014307 dimer interface [polypeptide binding]; other site 1286404014308 catalytic triad [active] 1286404014309 Phosphoglycerate kinase; Region: PGK; pfam00162 1286404014310 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1286404014311 substrate binding site [chemical binding]; other site 1286404014312 hinge regions; other site 1286404014313 ADP binding site [chemical binding]; other site 1286404014314 catalytic site [active] 1286404014315 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1286404014316 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1286404014317 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1286404014318 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1286404014319 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1286404014320 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1286404014321 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1286404014322 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1286404014323 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1286404014324 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1286404014325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404014326 Histidine kinase; Region: HisKA_3; pfam07730 1286404014327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404014328 ATP binding site [chemical binding]; other site 1286404014329 Mg2+ binding site [ion binding]; other site 1286404014330 G-X-G motif; other site 1286404014331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404014332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404014333 active site 1286404014334 phosphorylation site [posttranslational modification] 1286404014335 intermolecular recognition site; other site 1286404014336 dimerization interface [polypeptide binding]; other site 1286404014337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404014338 DNA binding residues [nucleotide binding] 1286404014339 dimerization interface [polypeptide binding]; other site 1286404014340 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1286404014341 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1286404014342 stage V sporulation protein AD; Provisional; Region: PRK12404 1286404014343 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1286404014344 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1286404014345 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1286404014346 Predicted membrane protein [Function unknown]; Region: COG2323 1286404014347 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1286404014348 Clp protease; Region: CLP_protease; pfam00574 1286404014349 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1286404014350 oligomer interface [polypeptide binding]; other site 1286404014351 active site residues [active] 1286404014352 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1286404014353 dimerization domain swap beta strand [polypeptide binding]; other site 1286404014354 regulatory protein interface [polypeptide binding]; other site 1286404014355 active site 1286404014356 regulatory phosphorylation site [posttranslational modification]; other site 1286404014357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1286404014358 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1286404014359 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1286404014360 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1286404014361 phosphate binding site [ion binding]; other site 1286404014362 putative substrate binding pocket [chemical binding]; other site 1286404014363 dimer interface [polypeptide binding]; other site 1286404014364 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1286404014365 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1286404014366 putative active site [active] 1286404014367 nucleotide binding site [chemical binding]; other site 1286404014368 nudix motif; other site 1286404014369 putative metal binding site [ion binding]; other site 1286404014370 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1286404014371 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1286404014372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404014373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404014374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404014375 binding surface 1286404014376 TPR motif; other site 1286404014377 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404014378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404014379 binding surface 1286404014380 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1286404014381 TPR motif; other site 1286404014382 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1286404014383 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1286404014384 trimer interface [polypeptide binding]; other site 1286404014385 active site 1286404014386 substrate binding site [chemical binding]; other site 1286404014387 CoA binding site [chemical binding]; other site 1286404014388 pyrophosphatase PpaX; Provisional; Region: PRK13288 1286404014389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404014390 active site 1286404014391 motif I; other site 1286404014392 motif II; other site 1286404014393 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1286404014394 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1286404014395 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1286404014396 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1286404014397 Hpr binding site; other site 1286404014398 active site 1286404014399 homohexamer subunit interaction site [polypeptide binding]; other site 1286404014400 Predicted membrane protein [Function unknown]; Region: COG1950 1286404014401 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 1286404014402 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1286404014403 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1286404014404 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1286404014405 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1286404014406 excinuclease ABC subunit B; Provisional; Region: PRK05298 1286404014407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404014408 ATP binding site [chemical binding]; other site 1286404014409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404014410 nucleotide binding region [chemical binding]; other site 1286404014411 ATP-binding site [chemical binding]; other site 1286404014412 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1286404014413 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 1286404014414 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1286404014415 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404014416 DNA binding residues [nucleotide binding] 1286404014417 dimer interface [polypeptide binding]; other site 1286404014418 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286404014419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404014420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404014421 non-specific DNA binding site [nucleotide binding]; other site 1286404014422 salt bridge; other site 1286404014423 sequence-specific DNA binding site [nucleotide binding]; other site 1286404014424 Predicted membrane protein [Function unknown]; Region: COG2855 1286404014425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404014426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404014427 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1286404014428 putative dimerization interface [polypeptide binding]; other site 1286404014429 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1286404014430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404014431 DNA binding residues [nucleotide binding] 1286404014432 putative dimer interface [polypeptide binding]; other site 1286404014433 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1286404014434 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404014435 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404014436 hypothetical protein; Provisional; Region: PRK12855 1286404014437 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404014438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404014439 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1286404014440 Walker A/P-loop; other site 1286404014441 ATP binding site [chemical binding]; other site 1286404014442 Q-loop/lid; other site 1286404014443 ABC transporter signature motif; other site 1286404014444 Walker B; other site 1286404014445 D-loop; other site 1286404014446 H-loop/switch region; other site 1286404014447 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286404014448 protein binding site [polypeptide binding]; other site 1286404014449 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1286404014450 C-terminal peptidase (prc); Region: prc; TIGR00225 1286404014451 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1286404014452 protein binding site [polypeptide binding]; other site 1286404014453 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1286404014454 Catalytic dyad [active] 1286404014455 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286404014456 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1286404014457 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1286404014458 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1286404014459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404014460 Walker A/P-loop; other site 1286404014461 ATP binding site [chemical binding]; other site 1286404014462 Q-loop/lid; other site 1286404014463 ABC transporter signature motif; other site 1286404014464 Walker B; other site 1286404014465 D-loop; other site 1286404014466 H-loop/switch region; other site 1286404014467 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1286404014468 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1286404014469 peptide chain release factor 2; Provisional; Region: PRK06746 1286404014470 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1286404014471 RF-1 domain; Region: RF-1; pfam00472 1286404014472 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1286404014473 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1286404014474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1286404014475 nucleotide binding region [chemical binding]; other site 1286404014476 ATP-binding site [chemical binding]; other site 1286404014477 SEC-C motif; Region: SEC-C; pfam02810 1286404014478 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1286404014479 30S subunit binding site; other site 1286404014480 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404014481 DNA-binding site [nucleotide binding]; DNA binding site 1286404014482 RNA-binding motif; other site 1286404014483 comF family protein; Region: comF; TIGR00201 1286404014484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404014485 active site 1286404014486 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1286404014487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404014488 ATP binding site [chemical binding]; other site 1286404014489 putative Mg++ binding site [ion binding]; other site 1286404014490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404014491 nucleotide binding region [chemical binding]; other site 1286404014492 ATP-binding site [chemical binding]; other site 1286404014493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1286404014494 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 1286404014495 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404014496 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404014497 Predicted transcriptional regulators [Transcription]; Region: COG1733 1286404014498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404014499 dimerization interface [polypeptide binding]; other site 1286404014500 putative DNA binding site [nucleotide binding]; other site 1286404014501 putative Zn2+ binding site [ion binding]; other site 1286404014502 EDD domain protein, DegV family; Region: DegV; TIGR00762 1286404014503 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1286404014504 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1286404014505 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1286404014506 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1286404014507 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1286404014508 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1286404014509 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1286404014510 active site 1286404014511 homodimer interface [polypeptide binding]; other site 1286404014512 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1286404014513 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286404014514 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286404014515 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1286404014516 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1286404014517 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1286404014518 Mg++ binding site [ion binding]; other site 1286404014519 putative catalytic motif [active] 1286404014520 substrate binding site [chemical binding]; other site 1286404014521 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1286404014522 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1286404014523 NodB motif; other site 1286404014524 active site 1286404014525 catalytic site [active] 1286404014526 Zn binding site [ion binding]; other site 1286404014527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404014528 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1286404014529 Walker A motif; other site 1286404014530 ATP binding site [chemical binding]; other site 1286404014531 Walker B motif; other site 1286404014532 arginine finger; other site 1286404014533 Transcriptional antiterminator [Transcription]; Region: COG3933 1286404014534 PRD domain; Region: PRD; pfam00874 1286404014535 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1286404014536 active pocket/dimerization site; other site 1286404014537 active site 1286404014538 phosphorylation site [posttranslational modification] 1286404014539 PRD domain; Region: PRD; pfam00874 1286404014540 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 1286404014541 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1286404014542 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1286404014543 Chromate transporter; Region: Chromate_transp; pfam02417 1286404014544 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1286404014545 putative active site [active] 1286404014546 YdjC motif; other site 1286404014547 Mg binding site [ion binding]; other site 1286404014548 putative homodimer interface [polypeptide binding]; other site 1286404014549 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1286404014550 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1286404014551 NAD binding site [chemical binding]; other site 1286404014552 sugar binding site [chemical binding]; other site 1286404014553 divalent metal binding site [ion binding]; other site 1286404014554 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404014555 dimer interface [polypeptide binding]; other site 1286404014556 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1286404014557 active site 1286404014558 methionine cluster; other site 1286404014559 phosphorylation site [posttranslational modification] 1286404014560 metal binding site [ion binding]; metal-binding site 1286404014561 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286404014562 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1286404014563 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286404014564 active site 1286404014565 P-loop; other site 1286404014566 phosphorylation site [posttranslational modification] 1286404014567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404014568 S-adenosylmethionine binding site [chemical binding]; other site 1286404014569 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 1286404014570 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1286404014571 methionine cluster; other site 1286404014572 active site 1286404014573 phosphorylation site [posttranslational modification] 1286404014574 metal binding site [ion binding]; metal-binding site 1286404014575 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1286404014576 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1286404014577 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1286404014578 active site 1286404014579 P-loop; other site 1286404014580 phosphorylation site [posttranslational modification] 1286404014581 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1286404014582 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1286404014583 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1286404014584 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1286404014585 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1286404014586 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1286404014587 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1286404014588 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1286404014589 Predicted membrane protein [Function unknown]; Region: COG1511 1286404014590 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1286404014591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404014592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404014593 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1286404014594 putative dimerization interface [polypeptide binding]; other site 1286404014595 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1286404014596 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1286404014597 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1286404014598 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1286404014599 transmembrane helices; other site 1286404014600 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1286404014601 ThiC-associated domain; Region: ThiC-associated; pfam13667 1286404014602 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1286404014603 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404014604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404014605 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404014606 L-lactate permease; Region: Lactate_perm; cl00701 1286404014607 glycolate transporter; Provisional; Region: PRK09695 1286404014608 Tic20-like protein; Region: Tic20; pfam09685 1286404014609 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1286404014610 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1286404014611 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1286404014612 Sulfatase; Region: Sulfatase; pfam00884 1286404014613 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1286404014614 homodimer interface [polypeptide binding]; other site 1286404014615 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1286404014616 substrate-cofactor binding pocket; other site 1286404014617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404014618 catalytic residue [active] 1286404014619 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014620 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014621 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014622 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014623 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014624 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404014625 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404014626 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1286404014627 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1286404014628 Nucleoside recognition; Region: Gate; pfam07670 1286404014629 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1286404014630 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1286404014631 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1286404014632 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1286404014633 DXD motif; other site 1286404014634 BCCT family transporter; Region: BCCT; pfam02028 1286404014635 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014636 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404014637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1286404014638 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 1286404014639 Predicted membrane protein [Function unknown]; Region: COG4640 1286404014640 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1286404014641 Double zinc ribbon; Region: DZR; pfam12773 1286404014642 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1286404014643 Double zinc ribbon; Region: DZR; pfam12773 1286404014644 SNF2 Helicase protein; Region: DUF3670; pfam12419 1286404014645 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1286404014646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404014647 ATP binding site [chemical binding]; other site 1286404014648 putative Mg++ binding site [ion binding]; other site 1286404014649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404014650 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1286404014651 nucleotide binding region [chemical binding]; other site 1286404014652 ATP-binding site [chemical binding]; other site 1286404014653 Predicted integral membrane protein [Function unknown]; Region: COG5652 1286404014654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404014655 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404014656 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404014657 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 1286404014658 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1286404014659 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1286404014660 ComK protein; Region: ComK; cl11560 1286404014661 RNA polymerase factor sigma-70; Validated; Region: PRK06759 1286404014662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404014663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404014664 DNA binding residues [nucleotide binding] 1286404014665 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1286404014666 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404014667 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1286404014668 FtsX-like permease family; Region: FtsX; pfam02687 1286404014669 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404014670 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404014671 Walker A/P-loop; other site 1286404014672 ATP binding site [chemical binding]; other site 1286404014673 Q-loop/lid; other site 1286404014674 ABC transporter signature motif; other site 1286404014675 Walker B; other site 1286404014676 D-loop; other site 1286404014677 H-loop/switch region; other site 1286404014678 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1286404014679 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1286404014680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404014681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404014682 non-specific DNA binding site [nucleotide binding]; other site 1286404014683 salt bridge; other site 1286404014684 sequence-specific DNA binding site [nucleotide binding]; other site 1286404014685 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1286404014686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404014687 putative substrate translocation pore; other site 1286404014688 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1286404014689 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1286404014690 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 1286404014691 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1286404014692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404014693 dimerization interface [polypeptide binding]; other site 1286404014694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404014695 dimer interface [polypeptide binding]; other site 1286404014696 phosphorylation site [posttranslational modification] 1286404014697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404014698 ATP binding site [chemical binding]; other site 1286404014699 Mg2+ binding site [ion binding]; other site 1286404014700 G-X-G motif; other site 1286404014701 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404014702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404014703 active site 1286404014704 phosphorylation site [posttranslational modification] 1286404014705 intermolecular recognition site; other site 1286404014706 dimerization interface [polypeptide binding]; other site 1286404014707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404014708 DNA binding site [nucleotide binding] 1286404014709 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1286404014710 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1286404014711 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1286404014712 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1286404014713 active site 1286404014714 P-loop; other site 1286404014715 phosphorylation site [posttranslational modification] 1286404014716 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1286404014717 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286404014718 active site 1286404014719 phosphorylation site [posttranslational modification] 1286404014720 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1286404014721 HTH domain; Region: HTH_11; pfam08279 1286404014722 HTH domain; Region: HTH_11; pfam08279 1286404014723 PRD domain; Region: PRD; pfam00874 1286404014724 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1286404014725 active site 1286404014726 P-loop; other site 1286404014727 phosphorylation site [posttranslational modification] 1286404014728 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1286404014729 active site 1286404014730 phosphorylation site [posttranslational modification] 1286404014731 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1286404014732 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1286404014733 NAD binding site [chemical binding]; other site 1286404014734 homodimer interface [polypeptide binding]; other site 1286404014735 active site 1286404014736 substrate binding site [chemical binding]; other site 1286404014737 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1286404014738 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1286404014739 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1286404014740 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1286404014741 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404014742 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1286404014743 active site 1286404014744 Cupin domain; Region: Cupin_2; cl17218 1286404014745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404014746 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1286404014747 putative ADP-binding pocket [chemical binding]; other site 1286404014748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404014749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1286404014750 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1286404014751 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404014752 putative homodimer interface [polypeptide binding]; other site 1286404014753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404014754 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1286404014755 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1286404014756 trimer interface [polypeptide binding]; other site 1286404014757 active site 1286404014758 substrate binding site [chemical binding]; other site 1286404014759 CoA binding site [chemical binding]; other site 1286404014760 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1286404014761 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286404014762 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1286404014763 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1286404014764 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286404014765 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1286404014766 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1286404014767 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1286404014768 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286404014769 active site 1286404014770 tetramer interface; other site 1286404014771 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1286404014772 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1286404014773 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286404014774 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1286404014775 Chain length determinant protein; Region: Wzz; cl15801 1286404014776 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1286404014777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286404014778 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1286404014779 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1286404014780 MreB and similar proteins; Region: MreB_like; cd10225 1286404014781 nucleotide binding site [chemical binding]; other site 1286404014782 Mg binding site [ion binding]; other site 1286404014783 putative protofilament interaction site [polypeptide binding]; other site 1286404014784 RodZ interaction site [polypeptide binding]; other site 1286404014785 Stage III sporulation protein D; Region: SpoIIID; cl17560 1286404014786 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404014787 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404014788 CcmB protein; Region: CcmB; cl17444 1286404014789 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1286404014790 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404014791 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404014792 Walker A/P-loop; other site 1286404014793 ATP binding site [chemical binding]; other site 1286404014794 Q-loop/lid; other site 1286404014795 ABC transporter signature motif; other site 1286404014796 Walker B; other site 1286404014797 D-loop; other site 1286404014798 H-loop/switch region; other site 1286404014799 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1286404014800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404014801 Q-loop/lid; other site 1286404014802 ABC transporter signature motif; other site 1286404014803 Walker B; other site 1286404014804 D-loop; other site 1286404014805 H-loop/switch region; other site 1286404014806 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1286404014807 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286404014808 Stage II sporulation protein; Region: SpoIID; pfam08486 1286404014809 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1286404014810 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1286404014811 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1286404014812 hinge; other site 1286404014813 active site 1286404014814 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1286404014815 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1286404014816 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1286404014817 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286404014818 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1286404014819 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286404014820 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1286404014821 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1286404014822 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1286404014823 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1286404014824 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1286404014825 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1286404014826 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1286404014827 4Fe-4S binding domain; Region: Fer4; cl02805 1286404014828 4Fe-4S binding domain; Region: Fer4; pfam00037 1286404014829 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1286404014830 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1286404014831 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 1286404014832 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1286404014833 NADH dehydrogenase subunit C; Validated; Region: PRK07735 1286404014834 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1286404014835 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1286404014836 NADH dehydrogenase subunit A; Validated; Region: PRK07756 1286404014837 PAS domain S-box; Region: sensory_box; TIGR00229 1286404014838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404014839 putative active site [active] 1286404014840 heme pocket [chemical binding]; other site 1286404014841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404014842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404014843 metal binding site [ion binding]; metal-binding site 1286404014844 active site 1286404014845 I-site; other site 1286404014846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404014847 Protein of unknown function (DUF975); Region: DUF975; cl10504 1286404014848 Protein of unknown function (DUF975); Region: DUF975; cl10504 1286404014849 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1286404014850 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1286404014851 gamma subunit interface [polypeptide binding]; other site 1286404014852 epsilon subunit interface [polypeptide binding]; other site 1286404014853 LBP interface [polypeptide binding]; other site 1286404014854 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1286404014855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1286404014856 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1286404014857 alpha subunit interaction interface [polypeptide binding]; other site 1286404014858 Walker A motif; other site 1286404014859 ATP binding site [chemical binding]; other site 1286404014860 Walker B motif; other site 1286404014861 inhibitor binding site; inhibition site 1286404014862 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1286404014863 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1286404014864 core domain interface [polypeptide binding]; other site 1286404014865 delta subunit interface [polypeptide binding]; other site 1286404014866 epsilon subunit interface [polypeptide binding]; other site 1286404014867 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1286404014868 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1286404014869 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1286404014870 beta subunit interaction interface [polypeptide binding]; other site 1286404014871 Walker A motif; other site 1286404014872 ATP binding site [chemical binding]; other site 1286404014873 Walker B motif; other site 1286404014874 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1286404014875 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1286404014876 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1286404014877 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1286404014878 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1286404014879 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1286404014880 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1286404014881 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1286404014882 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1286404014883 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1286404014884 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 1286404014885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1286404014886 active site 1286404014887 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1286404014888 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1286404014889 dimer interface [polypeptide binding]; other site 1286404014890 active site 1286404014891 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1286404014892 folate binding site [chemical binding]; other site 1286404014893 hypothetical protein; Provisional; Region: PRK13690 1286404014894 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1286404014895 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1286404014896 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1286404014897 active site 1286404014898 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1286404014899 HPr interaction site; other site 1286404014900 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1286404014901 active site 1286404014902 phosphorylation site [posttranslational modification] 1286404014903 Predicted membrane protein [Function unknown]; Region: COG2259 1286404014904 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1286404014905 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 1286404014906 Predicted membrane protein [Function unknown]; Region: COG1971 1286404014907 Domain of unknown function DUF; Region: DUF204; pfam02659 1286404014908 Domain of unknown function DUF; Region: DUF204; pfam02659 1286404014909 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1286404014910 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1286404014911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404014912 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1286404014913 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1286404014914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404014915 S-adenosylmethionine binding site [chemical binding]; other site 1286404014916 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1286404014917 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1286404014918 RF-1 domain; Region: RF-1; pfam00472 1286404014919 thymidine kinase; Provisional; Region: PRK04296 1286404014920 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1286404014921 putative metal binding site [ion binding]; other site 1286404014922 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1286404014923 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1286404014924 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1286404014925 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1286404014926 RNA binding site [nucleotide binding]; other site 1286404014927 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1286404014928 multimer interface [polypeptide binding]; other site 1286404014929 Walker A motif; other site 1286404014930 ATP binding site [chemical binding]; other site 1286404014931 Walker B motif; other site 1286404014932 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1286404014933 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1286404014934 putative active site [active] 1286404014935 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1286404014936 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1286404014937 hinge; other site 1286404014938 active site 1286404014939 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1286404014940 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1286404014941 intersubunit interface [polypeptide binding]; other site 1286404014942 active site 1286404014943 zinc binding site [ion binding]; other site 1286404014944 Na+ binding site [ion binding]; other site 1286404014945 Response regulator receiver domain; Region: Response_reg; pfam00072 1286404014946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404014947 active site 1286404014948 phosphorylation site [posttranslational modification] 1286404014949 intermolecular recognition site; other site 1286404014950 dimerization interface [polypeptide binding]; other site 1286404014951 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1286404014952 CTP synthetase; Validated; Region: pyrG; PRK05380 1286404014953 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1286404014954 Catalytic site [active] 1286404014955 active site 1286404014956 UTP binding site [chemical binding]; other site 1286404014957 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1286404014958 active site 1286404014959 putative oxyanion hole; other site 1286404014960 catalytic triad [active] 1286404014961 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1286404014962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404014963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404014964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404014965 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1286404014966 FAD binding site [chemical binding]; other site 1286404014967 homotetramer interface [polypeptide binding]; other site 1286404014968 substrate binding pocket [chemical binding]; other site 1286404014969 catalytic base [active] 1286404014970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404014971 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1286404014972 FAD binding site [chemical binding]; other site 1286404014973 homotetramer interface [polypeptide binding]; other site 1286404014974 substrate binding pocket [chemical binding]; other site 1286404014975 catalytic base [active] 1286404014976 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1286404014977 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286404014978 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286404014979 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1286404014980 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1286404014981 dimer interface [polypeptide binding]; other site 1286404014982 active site 1286404014983 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1286404014984 4Fe-4S binding domain; Region: Fer4; cl02805 1286404014985 Cysteine-rich domain; Region: CCG; pfam02754 1286404014986 Cysteine-rich domain; Region: CCG; pfam02754 1286404014987 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1286404014988 PLD-like domain; Region: PLDc_2; pfam13091 1286404014989 putative active site [active] 1286404014990 catalytic site [active] 1286404014991 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1286404014992 PLD-like domain; Region: PLDc_2; pfam13091 1286404014993 putative active site [active] 1286404014994 catalytic site [active] 1286404014995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404014996 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404014997 UV-endonuclease UvdE; Region: UvdE; cl10036 1286404014998 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 1286404014999 PAS domain S-box; Region: sensory_box; TIGR00229 1286404015000 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404015001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404015002 metal binding site [ion binding]; metal-binding site 1286404015003 active site 1286404015004 I-site; other site 1286404015005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404015006 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 1286404015007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404015008 non-specific DNA binding site [nucleotide binding]; other site 1286404015009 salt bridge; other site 1286404015010 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015011 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404015012 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1286404015013 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404015014 active site 1286404015015 Zn binding site [ion binding]; other site 1286404015016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404015017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404015018 active site 1286404015019 phosphorylation site [posttranslational modification] 1286404015020 intermolecular recognition site; other site 1286404015021 dimerization interface [polypeptide binding]; other site 1286404015022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404015023 DNA binding residues [nucleotide binding] 1286404015024 dimerization interface [polypeptide binding]; other site 1286404015025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404015026 Histidine kinase; Region: HisKA_3; pfam07730 1286404015027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404015028 ATP binding site [chemical binding]; other site 1286404015029 Mg2+ binding site [ion binding]; other site 1286404015030 G-X-G motif; other site 1286404015031 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1286404015032 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1286404015033 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404015034 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1286404015035 Walker A/P-loop; other site 1286404015036 ATP binding site [chemical binding]; other site 1286404015037 Q-loop/lid; other site 1286404015038 ABC transporter signature motif; other site 1286404015039 Walker B; other site 1286404015040 D-loop; other site 1286404015041 H-loop/switch region; other site 1286404015042 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1286404015043 active site 1286404015044 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1286404015045 Collagen binding domain; Region: Collagen_bind; pfam05737 1286404015046 Collagen binding domain; Region: Collagen_bind; pfam05737 1286404015047 Collagen binding domain; Region: Collagen_bind; pfam05737 1286404015048 Collagen binding domain; Region: Collagen_bind; pfam05737 1286404015049 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015050 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015051 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015052 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015053 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015054 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015055 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015056 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1286404015057 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015058 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015059 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015060 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015061 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1286404015062 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015063 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015064 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015065 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015066 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015067 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1286404015068 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015069 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015070 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015071 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015072 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015073 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1286404015074 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1286404015075 PA/protease or protease-like domain interface [polypeptide binding]; other site 1286404015076 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1286404015077 Peptidase family M28; Region: Peptidase_M28; pfam04389 1286404015078 metal binding site [ion binding]; metal-binding site 1286404015079 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1286404015080 RNA polymerase sigma factor; Provisional; Region: PRK12522 1286404015081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404015082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404015083 DNA binding residues [nucleotide binding] 1286404015084 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1286404015085 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1286404015086 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1286404015087 active site 1286404015088 HIGH motif; other site 1286404015089 KMSK motif region; other site 1286404015090 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1286404015091 tRNA binding surface [nucleotide binding]; other site 1286404015092 anticodon binding site; other site 1286404015093 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1286404015094 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1286404015095 putative dimer interface [polypeptide binding]; other site 1286404015096 catalytic triad [active] 1286404015097 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1286404015098 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1286404015099 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1286404015100 agmatinase; Region: agmatinase; TIGR01230 1286404015101 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1286404015102 putative active site [active] 1286404015103 Mn binding site [ion binding]; other site 1286404015104 spermidine synthase; Provisional; Region: PRK00811 1286404015105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404015106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404015107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404015108 putative substrate translocation pore; other site 1286404015109 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404015110 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1286404015111 DNA binding residues [nucleotide binding] 1286404015112 putative dimer interface [polypeptide binding]; other site 1286404015113 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1286404015114 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1286404015115 active site 1286404015116 catalytic site [active] 1286404015117 metal binding site [ion binding]; metal-binding site 1286404015118 dimer interface [polypeptide binding]; other site 1286404015119 Transglycosylase; Region: Transgly; pfam00912 1286404015120 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1286404015121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1286404015122 YwhD family; Region: YwhD; pfam08741 1286404015123 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1286404015124 Peptidase family M50; Region: Peptidase_M50; pfam02163 1286404015125 active site 1286404015126 putative substrate binding region [chemical binding]; other site 1286404015127 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1286404015128 active site 1 [active] 1286404015129 dimer interface [polypeptide binding]; other site 1286404015130 hexamer interface [polypeptide binding]; other site 1286404015131 active site 2 [active] 1286404015132 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1286404015133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1286404015134 Zn2+ binding site [ion binding]; other site 1286404015135 Mg2+ binding site [ion binding]; other site 1286404015136 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1286404015137 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1286404015138 intersubunit interface [polypeptide binding]; other site 1286404015139 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1286404015140 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1286404015141 Walker A/P-loop; other site 1286404015142 ATP binding site [chemical binding]; other site 1286404015143 Q-loop/lid; other site 1286404015144 ABC transporter signature motif; other site 1286404015145 Walker B; other site 1286404015146 D-loop; other site 1286404015147 H-loop/switch region; other site 1286404015148 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1286404015149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404015150 ABC-ATPase subunit interface; other site 1286404015151 dimer interface [polypeptide binding]; other site 1286404015152 putative PBP binding regions; other site 1286404015153 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1286404015154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1286404015155 ABC-ATPase subunit interface; other site 1286404015156 dimer interface [polypeptide binding]; other site 1286404015157 putative PBP binding regions; other site 1286404015158 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1286404015159 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1286404015160 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1286404015161 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1286404015162 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1286404015163 putative heme peroxidase; Provisional; Region: PRK12276 1286404015164 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1286404015165 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1286404015166 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1286404015167 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1286404015168 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1286404015169 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1286404015170 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1286404015171 Ion channel; Region: Ion_trans_2; pfam07885 1286404015172 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1286404015173 TrkA-N domain; Region: TrkA_N; pfam02254 1286404015174 TrkA-C domain; Region: TrkA_C; pfam02080 1286404015175 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1286404015176 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1286404015177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404015178 motif II; other site 1286404015179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404015180 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1286404015181 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1286404015182 ligand binding site [chemical binding]; other site 1286404015183 active site 1286404015184 UGI interface [polypeptide binding]; other site 1286404015185 catalytic site [active] 1286404015186 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1286404015187 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1286404015188 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1286404015189 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404015190 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1286404015191 Walker A/P-loop; other site 1286404015192 ATP binding site [chemical binding]; other site 1286404015193 Q-loop/lid; other site 1286404015194 ABC transporter signature motif; other site 1286404015195 Walker B; other site 1286404015196 D-loop; other site 1286404015197 H-loop/switch region; other site 1286404015198 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1286404015199 active site 1286404015200 catalytic triad [active] 1286404015201 oxyanion hole [active] 1286404015202 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404015203 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404015204 DNA binding site [nucleotide binding] 1286404015205 domain linker motif; other site 1286404015206 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1286404015207 putative dimerization interface [polypeptide binding]; other site 1286404015208 putative ligand binding site [chemical binding]; other site 1286404015209 Predicted membrane protein [Function unknown]; Region: COG2364 1286404015210 homoserine dehydrogenase; Provisional; Region: PRK06349 1286404015211 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1286404015212 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1286404015213 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1286404015214 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1286404015215 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1286404015216 proposed active site lysine [active] 1286404015217 conserved cys residue [active] 1286404015218 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 1286404015219 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1286404015220 homodimer interface [polypeptide binding]; other site 1286404015221 substrate-cofactor binding pocket; other site 1286404015222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404015223 catalytic residue [active] 1286404015224 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1286404015225 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1286404015226 Cl- selectivity filter; other site 1286404015227 Cl- binding residues [ion binding]; other site 1286404015228 pore gating glutamate residue; other site 1286404015229 dimer interface [polypeptide binding]; other site 1286404015230 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1286404015231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404015232 active site 1286404015233 motif I; other site 1286404015234 motif II; other site 1286404015235 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1286404015236 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1286404015237 ligand binding site [chemical binding]; other site 1286404015238 flexible hinge region; other site 1286404015239 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1286404015240 azoreductase; Provisional; Region: PRK13556 1286404015241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404015242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404015243 active site 1286404015244 phosphorylation site [posttranslational modification] 1286404015245 intermolecular recognition site; other site 1286404015246 dimerization interface [polypeptide binding]; other site 1286404015247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404015248 DNA binding residues [nucleotide binding] 1286404015249 dimerization interface [polypeptide binding]; other site 1286404015250 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286404015251 GAF domain; Region: GAF; pfam01590 1286404015252 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286404015253 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286404015254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1286404015255 Histidine kinase; Region: HisKA_3; pfam07730 1286404015256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404015257 ATP binding site [chemical binding]; other site 1286404015258 Mg2+ binding site [ion binding]; other site 1286404015259 G-X-G motif; other site 1286404015260 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1286404015261 dimer interface [polypeptide binding]; other site 1286404015262 substrate binding site [chemical binding]; other site 1286404015263 ATP binding site [chemical binding]; other site 1286404015264 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286404015265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404015266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404015267 metal binding site [ion binding]; metal-binding site 1286404015268 active site 1286404015269 I-site; other site 1286404015270 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1286404015271 carbon starvation protein A; Provisional; Region: PRK15015 1286404015272 Carbon starvation protein CstA; Region: CstA; pfam02554 1286404015273 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1286404015274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404015275 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1286404015276 active site 1286404015277 phosphorylation site [posttranslational modification] 1286404015278 intermolecular recognition site; other site 1286404015279 dimerization interface [polypeptide binding]; other site 1286404015280 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286404015281 benzoate transport; Region: 2A0115; TIGR00895 1286404015282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404015283 putative substrate translocation pore; other site 1286404015284 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1286404015285 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1286404015286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404015287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286404015288 Predicted membrane protein [Function unknown]; Region: COG2860 1286404015289 UPF0126 domain; Region: UPF0126; pfam03458 1286404015290 UPF0126 domain; Region: UPF0126; pfam03458 1286404015291 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1286404015292 heme-binding site [chemical binding]; other site 1286404015293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404015294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404015295 dimer interface [polypeptide binding]; other site 1286404015296 putative CheW interface [polypeptide binding]; other site 1286404015297 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1286404015298 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1286404015299 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404015300 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1286404015301 Ligand binding site; other site 1286404015302 Putative Catalytic site; other site 1286404015303 DXD motif; other site 1286404015304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404015305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286404015306 active site 1286404015307 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1286404015308 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1286404015309 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1286404015310 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1286404015311 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1286404015312 Ligand binding site; other site 1286404015313 Putative Catalytic site; other site 1286404015314 DXD motif; other site 1286404015315 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404015316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404015317 NAD(P) binding site [chemical binding]; other site 1286404015318 active site 1286404015319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404015320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404015321 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1286404015322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404015323 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404015324 ABC transporter; Region: ABC_tran_2; pfam12848 1286404015325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1286404015326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404015327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404015328 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1286404015329 Protein export membrane protein; Region: SecD_SecF; cl14618 1286404015330 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1286404015331 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1286404015332 SelR domain; Region: SelR; pfam01641 1286404015333 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1286404015334 antiholin-like protein LrgB; Provisional; Region: PRK04288 1286404015335 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1286404015336 two-component response regulator; Provisional; Region: PRK14084 1286404015337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404015338 active site 1286404015339 phosphorylation site [posttranslational modification] 1286404015340 intermolecular recognition site; other site 1286404015341 dimerization interface [polypeptide binding]; other site 1286404015342 LytTr DNA-binding domain; Region: LytTR; pfam04397 1286404015343 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1286404015344 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1286404015345 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286404015346 Histidine kinase; Region: His_kinase; pfam06580 1286404015347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404015348 ATP binding site [chemical binding]; other site 1286404015349 Mg2+ binding site [ion binding]; other site 1286404015350 G-X-G motif; other site 1286404015351 benzoate transport; Region: 2A0115; TIGR00895 1286404015352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404015353 putative substrate translocation pore; other site 1286404015354 BCCT family transporter; Region: BCCT; pfam02028 1286404015355 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1286404015356 active site 1286404015357 dimer interface [polypeptide binding]; other site 1286404015358 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1286404015359 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1286404015360 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1286404015361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404015362 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1286404015363 NAD(P) binding site [chemical binding]; other site 1286404015364 active site 1286404015365 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1286404015366 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1286404015367 UDP-glucose 4-epimerase; Region: PLN02240 1286404015368 NAD binding site [chemical binding]; other site 1286404015369 homodimer interface [polypeptide binding]; other site 1286404015370 active site 1286404015371 substrate binding site [chemical binding]; other site 1286404015372 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1286404015373 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1286404015374 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1286404015375 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1286404015376 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1286404015377 ATP binding site [chemical binding]; other site 1286404015378 Mg++ binding site [ion binding]; other site 1286404015379 motif III; other site 1286404015380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404015381 nucleotide binding region [chemical binding]; other site 1286404015382 ATP-binding site [chemical binding]; other site 1286404015383 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1286404015384 RNA binding site [nucleotide binding]; other site 1286404015385 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1286404015386 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1286404015387 active site 1286404015388 oligoendopeptidase F; Region: pepF; TIGR00181 1286404015389 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1286404015390 active site 1286404015391 Zn binding site [ion binding]; other site 1286404015392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404015393 FeS/SAM binding site; other site 1286404015394 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1286404015395 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1286404015396 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1286404015397 GAF domain; Region: GAF_3; pfam13492 1286404015398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404015399 PAS domain; Region: PAS_9; pfam13426 1286404015400 putative active site [active] 1286404015401 heme pocket [chemical binding]; other site 1286404015402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404015403 dimer interface [polypeptide binding]; other site 1286404015404 phosphorylation site [posttranslational modification] 1286404015405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404015406 ATP binding site [chemical binding]; other site 1286404015407 Mg2+ binding site [ion binding]; other site 1286404015408 G-X-G motif; other site 1286404015409 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1286404015410 YyzF-like protein; Region: YyzF; pfam14116 1286404015411 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1286404015412 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1286404015413 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1286404015414 protein binding site [polypeptide binding]; other site 1286404015415 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1286404015416 YycH protein; Region: YycI; pfam09648 1286404015417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1286404015418 YycH protein; Region: YycH; pfam07435 1286404015419 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1286404015420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1286404015421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404015422 dimerization interface [polypeptide binding]; other site 1286404015423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404015424 putative active site [active] 1286404015425 heme pocket [chemical binding]; other site 1286404015426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404015427 dimer interface [polypeptide binding]; other site 1286404015428 phosphorylation site [posttranslational modification] 1286404015429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404015430 ATP binding site [chemical binding]; other site 1286404015431 Mg2+ binding site [ion binding]; other site 1286404015432 G-X-G motif; other site 1286404015433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404015434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404015435 active site 1286404015436 phosphorylation site [posttranslational modification] 1286404015437 intermolecular recognition site; other site 1286404015438 dimerization interface [polypeptide binding]; other site 1286404015439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404015440 DNA binding site [nucleotide binding] 1286404015441 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1286404015442 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1286404015443 GDP-binding site [chemical binding]; other site 1286404015444 ACT binding site; other site 1286404015445 IMP binding site; other site 1286404015446 replicative DNA helicase; Provisional; Region: PRK05748 1286404015447 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1286404015448 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1286404015449 Walker A motif; other site 1286404015450 ATP binding site [chemical binding]; other site 1286404015451 Walker B motif; other site 1286404015452 DNA binding loops [nucleotide binding] 1286404015453 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1286404015454 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1286404015455 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1286404015456 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1286404015457 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1286404015458 DHH family; Region: DHH; pfam01368 1286404015459 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1286404015460 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1286404015461 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1286404015462 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1286404015463 dimer interface [polypeptide binding]; other site 1286404015464 ssDNA binding site [nucleotide binding]; other site 1286404015465 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1286404015466 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1286404015467 GTP-binding protein YchF; Reviewed; Region: PRK09601 1286404015468 YchF GTPase; Region: YchF; cd01900 1286404015469 G1 box; other site 1286404015470 GTP/Mg2+ binding site [chemical binding]; other site 1286404015471 Switch I region; other site 1286404015472 G2 box; other site 1286404015473 Switch II region; other site 1286404015474 G3 box; other site 1286404015475 G4 box; other site 1286404015476 G5 box; other site 1286404015477 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1286404015478 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1286404015479 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1286404015480 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1286404015481 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1286404015482 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1286404015483 ParB-like nuclease domain; Region: ParB; smart00470 1286404015484 KorB domain; Region: KorB; pfam08535 1286404015485 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1286404015486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286404015487 P-loop; other site 1286404015488 Magnesium ion binding site [ion binding]; other site 1286404015489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1286404015490 Magnesium ion binding site [ion binding]; other site 1286404015491 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1286404015492 ParB-like nuclease domain; Region: ParBc; pfam02195 1286404015493 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1286404015494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404015495 S-adenosylmethionine binding site [chemical binding]; other site 1286404015496 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1286404015497 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1286404015498 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1286404015499 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1286404015500 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1286404015501 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1286404015502 G1 box; other site 1286404015503 GTP/Mg2+ binding site [chemical binding]; other site 1286404015504 Switch I region; other site 1286404015505 G2 box; other site 1286404015506 Switch II region; other site 1286404015507 G3 box; other site 1286404015508 G4 box; other site 1286404015509 G5 box; other site 1286404015510 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1286404015511 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1286404015512 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1286404015513 G-X-X-G motif; other site 1286404015514 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1286404015515 RxxxH motif; other site 1286404015516 OxaA-like protein precursor; Validated; Region: PRK02944 1286404015517 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1286404015518 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1286404015519 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1286404015520 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1286404015521 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015522 salt bridge; other site 1286404015523 Replication protein; Region: Rep_1; cl02412 1286404015524 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1286404015525 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1286404015526 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1286404015527 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1286404015528 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404015529 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404015530 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404015531 active site 1286404015532 catalytic residues [active] 1286404015533 DNA binding site [nucleotide binding] 1286404015534 Int/Topo IB signature motif; other site 1286404015535 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1286404015536 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1286404015537 MarR family; Region: MarR_2; pfam12802 1286404015538 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1286404015539 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1286404015540 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015541 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1286404015542 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1286404015543 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404015544 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404015545 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404015546 active site 1286404015547 catalytic residues [active] 1286404015548 DNA binding site [nucleotide binding] 1286404015549 Int/Topo IB signature motif; other site 1286404015550 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404015551 DNA binding residues [nucleotide binding] 1286404015552 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1286404015553 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1286404015554 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1286404015555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404015556 TPR motif; other site 1286404015557 binding surface 1286404015558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404015559 TPR motif; other site 1286404015560 binding surface 1286404015561 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404015562 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404015563 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1286404015564 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1286404015565 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1286404015566 Probable transposase; Region: OrfB_IS605; pfam01385 1286404015567 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1286404015568 Peptidase family M48; Region: Peptidase_M48; cl12018 1286404015569 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404015570 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404015571 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404015572 active site 1286404015573 catalytic residues [active] 1286404015574 DNA binding site [nucleotide binding] 1286404015575 Int/Topo IB signature motif; other site 1286404015576 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404015577 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404015578 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404015579 active site 1286404015580 catalytic residues [active] 1286404015581 DNA binding site [nucleotide binding] 1286404015582 Int/Topo IB signature motif; other site 1286404015583 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1286404015584 ORF6C domain; Region: ORF6C; pfam10552 1286404015585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1286404015586 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015587 salt bridge; other site 1286404015588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404015589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404015590 non-specific DNA binding site [nucleotide binding]; other site 1286404015591 salt bridge; other site 1286404015592 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015593 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1286404015594 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1286404015595 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404015596 DNA binding residues [nucleotide binding] 1286404015597 plasmid segregation protein ParM; Provisional; Region: PRK13917 1286404015598 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404015599 Mg binding site [ion binding]; other site 1286404015600 nucleotide binding site [chemical binding]; other site 1286404015601 putative protofilament interface [polypeptide binding]; other site 1286404015602 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 1286404015603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404015604 TPR motif; other site 1286404015605 binding surface 1286404015606 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1286404015607 active site 1286404015608 Helix-turn-helix domain; Region: HTH_17; cl17695 1286404015609 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404015610 amidase catalytic site [active] 1286404015611 Zn binding residues [ion binding]; other site 1286404015612 substrate binding site [chemical binding]; other site 1286404015613 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404015614 Holin family; Region: Phage_holin_4; cl01989 1286404015615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404015616 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404015617 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404015618 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 1286404015619 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 1286404015620 Phage-related minor tail protein [Function unknown]; Region: COG5280 1286404015621 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1286404015622 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1286404015623 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1286404015624 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404015625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1286404015626 DNA binding residues [nucleotide binding] 1286404015627 dimerization interface [polypeptide binding]; other site 1286404015628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404015629 dimerization interface [polypeptide binding]; other site 1286404015630 putative DNA binding site [nucleotide binding]; other site 1286404015631 putative Zn2+ binding site [ion binding]; other site 1286404015632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404015633 Integrase core domain; Region: rve; pfam00665 1286404015634 transposase/IS protein; Provisional; Region: PRK09183 1286404015635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404015636 Walker A motif; other site 1286404015637 ATP binding site [chemical binding]; other site 1286404015638 Walker B motif; other site 1286404015639 arginine finger; other site 1286404015640 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015641 bacterial Hfq-like; Region: Hfq; cd01716 1286404015642 hexamer interface [polypeptide binding]; other site 1286404015643 Sm1 motif; other site 1286404015644 RNA binding site [nucleotide binding]; other site 1286404015645 Sm2 motif; other site 1286404015646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404015647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404015648 TPR motif; other site 1286404015649 binding surface 1286404015650 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1286404015651 DNA topoisomerase III; Provisional; Region: PRK07726 1286404015652 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1286404015653 active site 1286404015654 putative interdomain interaction site [polypeptide binding]; other site 1286404015655 putative metal-binding site [ion binding]; other site 1286404015656 putative nucleotide binding site [chemical binding]; other site 1286404015657 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286404015658 domain I; other site 1286404015659 DNA binding groove [nucleotide binding] 1286404015660 phosphate binding site [ion binding]; other site 1286404015661 domain II; other site 1286404015662 domain III; other site 1286404015663 nucleotide binding site [chemical binding]; other site 1286404015664 catalytic site [active] 1286404015665 domain IV; other site 1286404015666 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404015667 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404015668 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404015669 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015670 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1286404015671 active site 1286404015672 DNA binding site [nucleotide binding] 1286404015673 Int/Topo IB signature motif; other site 1286404015674 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404015675 DNA binding residues [nucleotide binding] 1286404015676 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 1286404015677 Fic/DOC family; Region: Fic; cl00960 1286404015678 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 1286404015679 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1286404015680 YopX protein; Region: YopX; pfam09643 1286404015681 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 1286404015682 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1286404015683 proximal heme binding site [chemical binding]; other site 1286404015684 Iron-sulfur protein interface; other site 1286404015685 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286404015686 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404015687 Walker A motif; other site 1286404015688 ATP binding site [chemical binding]; other site 1286404015689 Walker B motif; other site 1286404015690 AAA domain; Region: AAA_31; pfam13614 1286404015691 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286404015692 S-layer homology domain; Region: SLH; pfam00395 1286404015693 S-layer homology domain; Region: SLH; pfam00395 1286404015694 S-layer homology domain; Region: SLH; pfam00395 1286404015695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404015696 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1286404015697 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404015698 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404015699 AAA-like domain; Region: AAA_10; pfam12846 1286404015700 Domain of unknown function DUF87; Region: DUF87; pfam01935 1286404015701 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1286404015702 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404015703 Walker A motif; other site 1286404015704 ATP binding site [chemical binding]; other site 1286404015705 Walker B motif; other site 1286404015706 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404015707 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1286404015708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015709 active site 1286404015710 DNA binding site [nucleotide binding] 1286404015711 Int/Topo IB signature motif; other site 1286404015712 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1286404015713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015714 active site 1286404015715 DNA binding site [nucleotide binding] 1286404015716 Int/Topo IB signature motif; other site 1286404015717 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286404015718 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404015719 Mg binding site [ion binding]; other site 1286404015720 nucleotide binding site [chemical binding]; other site 1286404015721 putative protofilament interface [polypeptide binding]; other site 1286404015722 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1286404015723 putative active site [active] 1286404015724 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286404015725 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404015726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404015727 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404015728 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404015729 Predicted transcriptional regulators [Transcription]; Region: COG1695 1286404015730 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1286404015731 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1286404015732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404015733 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015734 salt bridge; other site 1286404015735 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 1286404015736 YolD-like protein; Region: YolD; pfam08863 1286404015737 Y-family of DNA polymerases; Region: PolY; cl12025 1286404015738 DNA binding site [nucleotide binding] 1286404015739 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286404015740 impB/mucB/samB family; Region: IMS; pfam00817 1286404015741 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1286404015742 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1286404015743 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1286404015744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404015745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404015746 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1286404015747 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1286404015748 PHB binding site; other site 1286404015749 subunit interaction site [polypeptide binding]; other site 1286404015750 CoenzymeA binding site [chemical binding]; other site 1286404015751 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1286404015752 Y-family of DNA polymerases; Region: PolY; cl12025 1286404015753 active site 1286404015754 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1286404015755 YueH-like protein; Region: YueH; pfam14166 1286404015756 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1286404015757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015758 active site 1286404015759 DNA binding site [nucleotide binding] 1286404015760 Int/Topo IB signature motif; other site 1286404015761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404015762 Integrase core domain; Region: rve; pfam00665 1286404015763 transposase/IS protein; Provisional; Region: PRK09183 1286404015764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404015765 Walker A motif; other site 1286404015766 ATP binding site [chemical binding]; other site 1286404015767 Walker B motif; other site 1286404015768 arginine finger; other site 1286404015769 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1286404015770 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1286404015771 active site 1286404015772 ATP binding site [chemical binding]; other site 1286404015773 substrate binding site [chemical binding]; other site 1286404015774 activation loop (A-loop); other site 1286404015775 AAA domain; Region: AAA_11; pfam13086 1286404015776 Part of AAA domain; Region: AAA_19; pfam13245 1286404015777 AAA domain; Region: AAA_30; pfam13604 1286404015778 AAA domain; Region: AAA_12; pfam13087 1286404015779 multi drug resistance-associated protein (MRP); Region: MRP_assoc_pro; TIGR00957 1286404015780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404015781 dimerization interface [polypeptide binding]; other site 1286404015782 putative DNA binding site [nucleotide binding]; other site 1286404015783 putative Zn2+ binding site [ion binding]; other site 1286404015784 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404015785 bacterial Hfq-like; Region: Hfq; cd01716 1286404015786 hexamer interface [polypeptide binding]; other site 1286404015787 Sm1 motif; other site 1286404015788 RNA binding site [nucleotide binding]; other site 1286404015789 Sm2 motif; other site 1286404015790 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1286404015791 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404015792 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286404015793 catalytic residues [active] 1286404015794 catalytic nucleophile [active] 1286404015795 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286404015796 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286404015797 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286404015798 Synaptic Site I dimer interface [polypeptide binding]; other site 1286404015799 DNA binding site [nucleotide binding] 1286404015800 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1286404015801 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1286404015802 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1286404015803 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1286404015804 catalytic residues [active] 1286404015805 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1286404015806 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1286404015807 active site 1286404015808 catalytic residues [active] 1286404015809 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1286404015810 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1286404015811 ATP binding site [chemical binding]; other site 1286404015812 substrate interface [chemical binding]; other site 1286404015813 KDPG and KHG aldolase; Region: Aldolase; cl17259 1286404015814 Initiator Replication protein; Region: Rep_3; pfam01051 1286404015815 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1286404015816 Putative zinc-finger; Region: zf-HC2; pfam13490 1286404015817 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1286404015818 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1286404015819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404015820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404015821 DNA binding residues [nucleotide binding] 1286404015822 conjugal transfer protein TrbE; Provisional; Region: PRK13830 1286404015823 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1286404015824 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404015825 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404015826 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1286404015827 AAA-like domain; Region: AAA_10; pfam12846 1286404015828 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404015829 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404015830 putative active site [active] 1286404015831 putative NTP binding site [chemical binding]; other site 1286404015832 putative nucleic acid binding site [nucleotide binding]; other site 1286404015833 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404015834 active site 1286404015835 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404015836 Walker A motif; other site 1286404015837 ATP binding site [chemical binding]; other site 1286404015838 TcpE family; Region: TcpE; pfam12648 1286404015839 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1286404015840 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404015841 AAA-like domain; Region: AAA_10; pfam12846 1286404015842 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015843 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015844 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015845 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015846 Cna protein B-type domain; Region: Cna_B; pfam05738 1286404015847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015849 TQXA domain; Region: TQXA_dom; TIGR03934 1286404015850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404015851 non-specific DNA binding site [nucleotide binding]; other site 1286404015852 salt bridge; other site 1286404015853 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404015855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404015856 non-specific DNA binding site [nucleotide binding]; other site 1286404015857 salt bridge; other site 1286404015858 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015859 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1286404015860 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015861 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404015862 active site 1286404015863 catalytic residues [active] 1286404015864 DNA binding site [nucleotide binding] 1286404015865 Int/Topo IB signature motif; other site 1286404015866 Helix-turn-helix domain; Region: HTH_17; pfam12728 1286404015867 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404015868 Mg binding site [ion binding]; other site 1286404015869 nucleotide binding site [chemical binding]; other site 1286404015870 putative protofilament interface [polypeptide binding]; other site 1286404015871 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404015872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1286404015873 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404015874 CryBP1 protein; Region: CryBP1; pfam07029 1286404015875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404015876 Integrase core domain; Region: rve; pfam00665 1286404015877 transposase/IS protein; Provisional; Region: PRK09183 1286404015878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404015879 Walker A motif; other site 1286404015880 ATP binding site [chemical binding]; other site 1286404015881 Walker B motif; other site 1286404015882 arginine finger; other site 1286404015883 CryBP1 protein; Region: CryBP1; pfam07029 1286404015884 Holin family; Region: Phage_holin_4; pfam05105 1286404015885 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1286404015886 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1286404015887 Fic family protein [Function unknown]; Region: COG3177 1286404015888 Fic/DOC family; Region: Fic; pfam02661 1286404015889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404015890 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404015891 Probable transposase; Region: OrfB_IS605; pfam01385 1286404015892 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404015893 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1286404015894 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1286404015895 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015896 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1286404015897 conformational flexibility of ligand binding pocket; other site 1286404015898 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1286404015899 active site 1286404015900 ADP-ribosylating toxin turn-turn motif; other site 1286404015901 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015902 EamA-like transporter family; Region: EamA; pfam00892 1286404015903 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404015904 EamA-like transporter family; Region: EamA; pfam00892 1286404015905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404015906 dimerization interface [polypeptide binding]; other site 1286404015907 putative DNA binding site [nucleotide binding]; other site 1286404015908 putative Zn2+ binding site [ion binding]; other site 1286404015909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404015910 SEC-C motif; Region: SEC-C; pfam02810 1286404015911 Flagellin N-methylase; Region: FliB; pfam03692 1286404015912 transposase/IS protein; Provisional; Region: PRK09183 1286404015913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404015914 Walker A motif; other site 1286404015915 ATP binding site [chemical binding]; other site 1286404015916 Walker B motif; other site 1286404015917 arginine finger; other site 1286404015918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404015919 Integrase core domain; Region: rve; pfam00665 1286404015920 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1286404015921 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1286404015922 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1286404015923 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1286404015924 Helix-turn-helix domain; Region: HTH_17; pfam12728 1286404015925 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015926 active site 1286404015927 Int/Topo IB signature motif; other site 1286404015928 DNA binding site [nucleotide binding] 1286404015929 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404015930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404015931 non-specific DNA binding site [nucleotide binding]; other site 1286404015932 salt bridge; other site 1286404015933 sequence-specific DNA binding site [nucleotide binding]; other site 1286404015934 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1286404015935 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1286404015936 peptide binding site [polypeptide binding]; other site 1286404015937 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286404015938 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404015939 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286404015940 IHF dimer interface [polypeptide binding]; other site 1286404015941 IHF - DNA interface [nucleotide binding]; other site 1286404015942 alanyl-tRNA synthetase; Provisional; Region: PRK01584 1286404015943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015945 DNA polymerase IV; Reviewed; Region: PRK03103 1286404015946 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1286404015947 active site 1286404015948 DNA binding site [nucleotide binding] 1286404015949 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286404015950 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404015951 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015952 active site 1286404015953 DNA binding site [nucleotide binding] 1286404015954 Int/Topo IB signature motif; other site 1286404015955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404015956 active site 1286404015957 DNA binding site [nucleotide binding] 1286404015958 Int/Topo IB signature motif; other site 1286404015959 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1286404015960 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404015961 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1286404015962 YolD-like protein; Region: YolD; pfam08863 1286404015963 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1286404015964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1286404015965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1286404015966 DNA binding residues [nucleotide binding] 1286404015967 Putative zinc-finger; Region: zf-HC2; pfam13490 1286404015968 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1286404015969 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404015970 EamA-like transporter family; Region: EamA; pfam00892 1286404015971 EamA-like transporter family; Region: EamA; pfam00892 1286404015972 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1286404015973 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1286404015974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404015975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404015976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404015977 dimerization interface [polypeptide binding]; other site 1286404015978 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1286404015979 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404015980 YolD-like protein; Region: YolD; pfam08863 1286404015981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404015982 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 1286404015983 Walker A motif; other site 1286404015984 ATP binding site [chemical binding]; other site 1286404015985 Walker B motif; other site 1286404015986 Family description; Region: UvrD_C_2; pfam13538 1286404015987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404015988 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1286404015989 LXG domain of WXG superfamily; Region: LXG; pfam04740 1286404015990 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1286404015991 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404015992 catalytic residues [active] 1286404015993 Predicted membrane protein [Function unknown]; Region: COG2311 1286404015994 Protein of unknown function (DUF418); Region: DUF418; cl12135 1286404015995 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1286404015996 CAAX protease self-immunity; Region: Abi; pfam02517 1286404015997 integrase; Provisional; Region: int; PHA02601 1286404015998 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1286404015999 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404016000 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404016001 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404016002 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404016003 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1286404016004 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016005 putative active site [active] 1286404016006 putative NTP binding site [chemical binding]; other site 1286404016007 putative nucleic acid binding site [nucleotide binding]; other site 1286404016008 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016009 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016010 Type II intron maturase; Region: Intron_maturas2; pfam01348 1286404016011 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1286404016012 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016013 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016014 putative active site [active] 1286404016015 putative NTP binding site [chemical binding]; other site 1286404016016 putative nucleic acid binding site [nucleotide binding]; other site 1286404016017 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404016018 active site 1286404016019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286404016020 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286404016021 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016022 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016023 putative active site [active] 1286404016024 putative NTP binding site [chemical binding]; other site 1286404016025 putative nucleic acid binding site [nucleotide binding]; other site 1286404016026 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404016027 active site 1286404016028 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1286404016029 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1286404016030 AAA-like domain; Region: AAA_10; pfam12846 1286404016031 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016032 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016033 putative active site [active] 1286404016034 putative NTP binding site [chemical binding]; other site 1286404016035 putative nucleic acid binding site [nucleotide binding]; other site 1286404016036 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404016037 active site 1286404016038 PrgI family protein; Region: PrgI; pfam12666 1286404016039 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1286404016040 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1286404016041 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1286404016042 active site 1286404016043 metal binding site [ion binding]; metal-binding site 1286404016044 interdomain interaction site; other site 1286404016045 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016046 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016047 putative active site [active] 1286404016048 putative NTP binding site [chemical binding]; other site 1286404016049 putative nucleic acid binding site [nucleotide binding]; other site 1286404016050 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404016051 active site 1286404016052 ARID/BRIGHT DNA binding domain; Region: ARID; cl02633 1286404016053 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286404016054 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404016055 Walker A motif; other site 1286404016056 ATP binding site [chemical binding]; other site 1286404016057 Walker B motif; other site 1286404016058 AAA domain; Region: AAA_31; pfam13614 1286404016059 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286404016060 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1286404016061 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286404016062 S-layer homology domain; Region: SLH; pfam00395 1286404016063 S-layer homology domain; Region: SLH; pfam00395 1286404016064 S-layer homology domain; Region: SLH; pfam00395 1286404016065 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 1286404016066 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 1286404016067 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404016068 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 1286404016069 DNA binding residues [nucleotide binding] 1286404016070 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286404016071 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1286404016072 nucleotide binding site [chemical binding]; other site 1286404016073 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404016074 Domain of unknown function (DUF373); Region: DUF373; cl12079 1286404016075 transposase/IS protein; Provisional; Region: PRK09183 1286404016076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404016077 Walker A motif; other site 1286404016078 ATP binding site [chemical binding]; other site 1286404016079 Walker B motif; other site 1286404016080 arginine finger; other site 1286404016081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404016082 Integrase core domain; Region: rve; pfam00665 1286404016083 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016084 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016085 putative active site [active] 1286404016086 putative nucleic acid binding site [nucleotide binding]; other site 1286404016087 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016088 Type II intron maturase; Region: Intron_maturas2; pfam01348 1286404016089 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016090 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016091 putative active site [active] 1286404016092 putative NTP binding site [chemical binding]; other site 1286404016093 putative nucleic acid binding site [nucleotide binding]; other site 1286404016094 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286404016095 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404016096 active site 1286404016097 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286404016098 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 1286404016099 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 1286404016100 DNA polymerase III subunit beta; Validated; Region: PRK05643 1286404016101 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1286404016102 putative DNA binding surface [nucleotide binding]; other site 1286404016103 dimer interface [polypeptide binding]; other site 1286404016104 beta-clamp/clamp loader binding surface; other site 1286404016105 beta-clamp/translesion DNA polymerase binding surface; other site 1286404016106 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 1286404016107 PRTRC system protein A; Region: PRTRC_A; TIGR03735 1286404016108 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 1286404016109 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1286404016110 ATP binding site [chemical binding]; other site 1286404016111 substrate interface [chemical binding]; other site 1286404016112 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286404016113 active site 1286404016114 NTP binding site [chemical binding]; other site 1286404016115 metal binding triad [ion binding]; metal-binding site 1286404016116 antibiotic binding site [chemical binding]; other site 1286404016117 HEPN domain; Region: HEPN; pfam05168 1286404016118 hypothetical protein; Provisional; Region: PRK06850 1286404016119 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1286404016120 Active Sites [active] 1286404016121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404016122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404016123 non-specific DNA binding site [nucleotide binding]; other site 1286404016124 salt bridge; other site 1286404016125 sequence-specific DNA binding site [nucleotide binding]; other site 1286404016126 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404016127 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404016128 active site 1286404016129 catalytic residues [active] 1286404016130 DNA binding site [nucleotide binding] 1286404016131 Int/Topo IB signature motif; other site 1286404016132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1286404016133 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1286404016134 TPR repeat; Region: TPR_11; pfam13414 1286404016135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404016136 binding surface 1286404016137 TPR motif; other site 1286404016138 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1286404016139 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1286404016140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1286404016141 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1286404016142 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1286404016143 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1286404016144 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016145 RNA polymerase beta subunit; Region: rpoB; CHL00001 1286404016146 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016147 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016148 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016149 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016150 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016151 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1286404016152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1286404016153 S-adenosylmethionine binding site [chemical binding]; other site 1286404016154 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016155 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016156 putative active site [active] 1286404016157 putative NTP binding site [chemical binding]; other site 1286404016158 putative nucleic acid binding site [nucleotide binding]; other site 1286404016159 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286404016160 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1286404016161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1286404016162 nucleotide binding region [chemical binding]; other site 1286404016163 ATP-binding site [chemical binding]; other site 1286404016164 Nuclease-related domain; Region: NERD; pfam08378 1286404016165 DNA topoisomerase III; Provisional; Region: PRK07726 1286404016166 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1286404016167 active site 1286404016168 putative interdomain interaction site [polypeptide binding]; other site 1286404016169 putative metal-binding site [ion binding]; other site 1286404016170 putative nucleotide binding site [chemical binding]; other site 1286404016171 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286404016172 domain I; other site 1286404016173 DNA binding groove [nucleotide binding] 1286404016174 phosphate binding site [ion binding]; other site 1286404016175 domain II; other site 1286404016176 domain III; other site 1286404016177 nucleotide binding site [chemical binding]; other site 1286404016178 catalytic site [active] 1286404016179 domain IV; other site 1286404016180 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1286404016181 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404016182 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404016183 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1286404016184 Staphylococcal nuclease homologues; Region: SNc; smart00318 1286404016185 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1286404016186 Catalytic site; other site 1286404016187 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1286404016188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016189 dimerization interface [polypeptide binding]; other site 1286404016190 putative DNA binding site [nucleotide binding]; other site 1286404016191 putative Zn2+ binding site [ion binding]; other site 1286404016192 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404016193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404016194 TPR motif; other site 1286404016195 binding surface 1286404016196 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1286404016197 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404016198 active site 1286404016199 DNA binding site [nucleotide binding] 1286404016200 Int/Topo IB signature motif; other site 1286404016201 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1286404016202 putative transposase OrfB; Reviewed; Region: PHA02517 1286404016203 HTH-like domain; Region: HTH_21; pfam13276 1286404016204 Integrase core domain; Region: rve; pfam00665 1286404016205 Integrase core domain; Region: rve_2; pfam13333 1286404016206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404016207 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404016208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404016209 Transposase; Region: HTH_Tnp_1; cl17663 1286404016210 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404016211 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1286404016212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016213 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404016214 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016215 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1286404016217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016218 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404016219 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016220 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016221 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404016222 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404016223 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1286404016224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1286404016225 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1286404016226 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1286404016227 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 1286404016228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016229 dimerization interface [polypeptide binding]; other site 1286404016230 putative DNA binding site [nucleotide binding]; other site 1286404016231 putative Zn2+ binding site [ion binding]; other site 1286404016232 SdpI/YhfL protein family; Region: SdpI; pfam13630 1286404016233 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1286404016234 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1286404016235 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1286404016236 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1286404016237 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1286404016238 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1286404016239 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1286404016240 active site 1286404016241 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1286404016242 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404016243 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1286404016244 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1286404016245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404016246 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1286404016247 dimerization interface [polypeptide binding]; other site 1286404016248 substrate binding pocket [chemical binding]; other site 1286404016249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016250 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404016251 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016252 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016253 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1286404016254 Transposase domain (DUF772); Region: DUF772; pfam05598 1286404016255 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1286404016256 HTH domain; Region: HTH_11; pfam08279 1286404016257 Mga helix-turn-helix domain; Region: Mga; pfam05043 1286404016258 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 1286404016259 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1286404016260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016261 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404016262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016263 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016264 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1286404016265 Bacillus thuringiensis delta-Endotoxin, middle domain; Region: Endotoxin_mid; pfam09131 1286404016266 delta endotoxin; Region: Endotoxin_C; pfam03944 1286404016267 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1286404016268 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1286404016269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404016270 dimerization interface [polypeptide binding]; other site 1286404016271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404016272 dimer interface [polypeptide binding]; other site 1286404016273 putative CheW interface [polypeptide binding]; other site 1286404016274 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1286404016275 TrkA-C domain; Region: TrkA_C; pfam02080 1286404016276 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404016277 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404016278 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404016279 amidase catalytic site [active] 1286404016280 Zn binding residues [ion binding]; other site 1286404016281 substrate binding site [chemical binding]; other site 1286404016282 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1286404016283 delta endotoxin; Region: Endotoxin_M; pfam00555 1286404016284 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1286404016285 putative metal binding site [ion binding]; other site 1286404016286 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1286404016287 delta endotoxin; Region: Endotoxin_M; pfam00555 1286404016288 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1286404016289 putative metal binding site [ion binding]; other site 1286404016290 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1286404016291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404016292 active site 1286404016293 DNA binding site [nucleotide binding] 1286404016294 Int/Topo IB signature motif; other site 1286404016295 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1286404016296 ADP-ribose binding site [chemical binding]; other site 1286404016297 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1286404016298 Bacillus thuringiensis delta-Endotoxin, middle domain; Region: Endotoxin_mid; pfam09131 1286404016299 delta endotoxin; Region: Endotoxin_C; pfam03944 1286404016300 DNA polymerase IV; Reviewed; Region: PRK03103 1286404016301 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1286404016302 active site 1286404016303 DNA binding site [nucleotide binding] 1286404016304 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286404016305 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1286404016306 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404016307 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404016308 active site 1286404016309 Zn binding site [ion binding]; other site 1286404016310 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1286404016311 catalytic core [active] 1286404016312 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1286404016313 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016314 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016315 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1286404016316 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1286404016317 putative catalytic site [active] 1286404016318 putative metal binding site [ion binding]; other site 1286404016319 putative phosphate binding site [ion binding]; other site 1286404016320 Nuclease-related domain; Region: NERD; pfam08378 1286404016321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1286404016322 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1286404016323 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1286404016324 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016325 dimerization interface [polypeptide binding]; other site 1286404016326 putative DNA binding site [nucleotide binding]; other site 1286404016327 putative Zn2+ binding site [ion binding]; other site 1286404016328 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404016329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404016330 TPR motif; other site 1286404016331 binding surface 1286404016332 PA14 domain; Region: PA14; cl08459 1286404016333 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 1286404016334 HTH domain; Region: HTH_11; pfam08279 1286404016335 Mga helix-turn-helix domain; Region: Mga; pfam05043 1286404016336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016337 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1286404016338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404016339 ATP binding site [chemical binding]; other site 1286404016340 G-X-G motif; other site 1286404016341 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1286404016342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404016343 active site 1286404016344 phosphorylation site [posttranslational modification] 1286404016345 intermolecular recognition site; other site 1286404016346 dimerization interface [polypeptide binding]; other site 1286404016347 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1286404016348 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1286404016349 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1286404016350 NAD binding site [chemical binding]; other site 1286404016351 Membrane transport protein; Region: Mem_trans; pfam03547 1286404016352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1286404016353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1286404016354 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1286404016355 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1286404016356 transmembrane helices; other site 1286404016357 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1286404016358 TPP-binding site [chemical binding]; other site 1286404016359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404016360 non-specific DNA binding site [nucleotide binding]; other site 1286404016361 salt bridge; other site 1286404016362 sequence-specific DNA binding site [nucleotide binding]; other site 1286404016363 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1286404016364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1286404016365 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1286404016366 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286404016367 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1286404016368 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1286404016369 active site 1286404016370 ADP-ribosylating toxin turn-turn motif; other site 1286404016371 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 1286404016372 active site 1286404016373 conformational flexibility of ligand binding pocket; other site 1286404016374 ADP-ribosylating toxin turn-turn motif; other site 1286404016375 PA14 domain; Region: PA14; cl08459 1286404016376 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 1286404016377 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1286404016378 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1286404016379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1286404016380 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 1286404016381 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1286404016382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404016383 active site 1286404016384 DNA binding site [nucleotide binding] 1286404016385 Int/Topo IB signature motif; other site 1286404016386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016387 dimerization interface [polypeptide binding]; other site 1286404016388 putative DNA binding site [nucleotide binding]; other site 1286404016389 putative Zn2+ binding site [ion binding]; other site 1286404016390 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1286404016391 active site 1286404016392 8-oxo-dGMP binding site [chemical binding]; other site 1286404016393 nudix motif; other site 1286404016394 metal binding site [ion binding]; metal-binding site 1286404016395 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1286404016396 putative active site [active] 1286404016397 Tar ligand binding domain homologue; Region: TarH; pfam02203 1286404016398 Cache domain; Region: Cache_1; pfam02743 1286404016399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404016400 dimerization interface [polypeptide binding]; other site 1286404016401 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1286404016402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404016403 dimer interface [polypeptide binding]; other site 1286404016404 putative CheW interface [polypeptide binding]; other site 1286404016405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1286404016406 TPR motif; other site 1286404016407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404016408 binding surface 1286404016409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404016410 TPR motif; other site 1286404016411 binding surface 1286404016412 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1286404016413 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404016414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286404016415 active site 1286404016416 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404016417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1286404016418 active site 1286404016419 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1286404016420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404016421 NAD(P) binding site [chemical binding]; other site 1286404016422 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1286404016423 active site 1286404016424 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404016425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404016426 NAD(P) binding site [chemical binding]; other site 1286404016427 active site 1286404016428 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1286404016429 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1286404016430 inhibitor-cofactor binding pocket; inhibition site 1286404016431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404016432 catalytic residue [active] 1286404016433 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1286404016434 ligand binding site; other site 1286404016435 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1286404016436 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1286404016437 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1286404016438 pseudaminic acid synthase; Region: PseI; TIGR03586 1286404016439 NeuB family; Region: NeuB; pfam03102 1286404016440 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1286404016441 NeuB binding interface [polypeptide binding]; other site 1286404016442 putative substrate binding site [chemical binding]; other site 1286404016443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1286404016444 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1286404016445 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1286404016446 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1286404016447 phosphate binding motif [ion binding]; other site 1286404016448 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1286404016449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1286404016450 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1286404016451 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404016452 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1286404016453 active site residue [active] 1286404016454 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404016455 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404016456 Walker A/P-loop; other site 1286404016457 ATP binding site [chemical binding]; other site 1286404016458 Q-loop/lid; other site 1286404016459 ABC transporter signature motif; other site 1286404016460 Walker B; other site 1286404016461 D-loop; other site 1286404016462 H-loop/switch region; other site 1286404016463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404016464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404016465 active site 1286404016466 phosphorylation site [posttranslational modification] 1286404016467 intermolecular recognition site; other site 1286404016468 dimerization interface [polypeptide binding]; other site 1286404016469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404016470 DNA binding site [nucleotide binding] 1286404016471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404016472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404016473 dimer interface [polypeptide binding]; other site 1286404016474 phosphorylation site [posttranslational modification] 1286404016475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404016476 ATP binding site [chemical binding]; other site 1286404016477 Mg2+ binding site [ion binding]; other site 1286404016478 G-X-G motif; other site 1286404016479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404016480 H+ Antiporter protein; Region: 2A0121; TIGR00900 1286404016481 putative substrate translocation pore; other site 1286404016482 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 1286404016483 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1286404016484 Ca binding site [ion binding]; other site 1286404016485 active site 1286404016486 catalytic site [active] 1286404016487 Aamy_C domain; Region: Aamy_C; smart00632 1286404016488 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 1286404016489 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1286404016490 starch-binding site 2 [chemical binding]; other site 1286404016491 starch-binding site 1 [chemical binding]; other site 1286404016492 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1286404016493 Putative esterase; Region: Esterase; pfam00756 1286404016494 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1286404016495 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1286404016496 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1286404016497 acyl-activating enzyme (AAE) consensus motif; other site 1286404016498 active site 1286404016499 AMP binding site [chemical binding]; other site 1286404016500 CoA binding site [chemical binding]; other site 1286404016501 Predicted membrane protein [Function unknown]; Region: COG2259 1286404016502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404016503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404016504 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404016505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404016506 putative substrate translocation pore; other site 1286404016507 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1286404016508 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1286404016509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1286404016510 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1286404016511 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1286404016512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1286404016513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1286404016514 active site 1286404016515 phosphorylation site [posttranslational modification] 1286404016516 intermolecular recognition site; other site 1286404016517 dimerization interface [polypeptide binding]; other site 1286404016518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1286404016519 DNA binding site [nucleotide binding] 1286404016520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404016521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404016522 dimerization interface [polypeptide binding]; other site 1286404016523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1286404016524 dimer interface [polypeptide binding]; other site 1286404016525 phosphorylation site [posttranslational modification] 1286404016526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404016527 ATP binding site [chemical binding]; other site 1286404016528 Mg2+ binding site [ion binding]; other site 1286404016529 G-X-G motif; other site 1286404016530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404016531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404016532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404016533 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1286404016534 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1286404016535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404016536 active site 1286404016537 DNA binding site [nucleotide binding] 1286404016538 Int/Topo IB signature motif; other site 1286404016539 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1286404016540 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1286404016541 active site 1286404016542 Zn binding site [ion binding]; other site 1286404016543 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 1286404016544 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1286404016545 active site 1286404016546 catalytic residues [active] 1286404016547 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1286404016548 Endonuclease I; Region: Endonuclease_1; pfam04231 1286404016549 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1286404016550 Stage II sporulation protein; Region: SpoIID; pfam08486 1286404016551 Stage II sporulation protein; Region: SpoIID; pfam08486 1286404016552 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1286404016553 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286404016554 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286404016555 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1286404016556 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286404016557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1286404016558 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1286404016559 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1286404016560 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1286404016561 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1286404016562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1286404016563 Divalent cation transporter; Region: MgtE; pfam01769 1286404016564 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1286404016565 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404016566 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404016567 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1286404016568 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1286404016569 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404016570 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404016571 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404016572 active site 1286404016573 catalytic residues [active] 1286404016574 DNA binding site [nucleotide binding] 1286404016575 Int/Topo IB signature motif; other site 1286404016576 bacterial Hfq-like; Region: Hfq; cd01716 1286404016577 hexamer interface [polypeptide binding]; other site 1286404016578 Sm1 motif; other site 1286404016579 RNA binding site [nucleotide binding]; other site 1286404016580 Sm2 motif; other site 1286404016581 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1286404016582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404016583 DNA-binding site [nucleotide binding]; DNA binding site 1286404016584 FCD domain; Region: FCD; pfam07729 1286404016585 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1286404016586 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1286404016587 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1286404016588 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1286404016589 homodimer interface [polypeptide binding]; other site 1286404016590 putative substrate binding pocket [chemical binding]; other site 1286404016591 diiron center [ion binding]; other site 1286404016592 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1286404016593 DNA-binding site [nucleotide binding]; DNA binding site 1286404016594 RNA-binding motif; other site 1286404016595 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1286404016596 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1286404016597 FOG: PKD repeat [General function prediction only]; Region: COG3291 1286404016598 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1286404016599 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1286404016600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404016601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404016602 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1286404016603 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1286404016604 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1286404016605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1286404016606 dimerization interface [polypeptide binding]; other site 1286404016607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404016608 dimer interface [polypeptide binding]; other site 1286404016609 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1286404016610 putative CheW interface [polypeptide binding]; other site 1286404016611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016612 dimerization interface [polypeptide binding]; other site 1286404016613 putative DNA binding site [nucleotide binding]; other site 1286404016614 putative Zn2+ binding site [ion binding]; other site 1286404016615 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1286404016616 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1286404016617 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1286404016618 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1286404016619 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1286404016620 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404016621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404016622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404016623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404016624 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1286404016625 transposase/IS protein; Provisional; Region: PRK09183 1286404016626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404016627 Walker A motif; other site 1286404016628 ATP binding site [chemical binding]; other site 1286404016629 Walker B motif; other site 1286404016630 arginine finger; other site 1286404016631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404016632 Integrase core domain; Region: rve; pfam00665 1286404016633 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1286404016634 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1286404016635 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1286404016636 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1286404016637 putative active site [active] 1286404016638 putative catalytic triad [active] 1286404016639 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1286404016640 active site 1286404016641 catalytic residues [active] 1286404016642 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016643 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016644 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1286404016645 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1286404016646 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1286404016647 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1286404016648 active site 1286404016649 catalytic residues [active] 1286404016650 Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857 1286404016651 Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857 1286404016652 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404016653 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404016654 active site 1286404016655 catalytic residues [active] 1286404016656 DNA binding site [nucleotide binding] 1286404016657 Int/Topo IB signature motif; other site 1286404016658 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404016659 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404016660 DNA binding residues [nucleotide binding] 1286404016661 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1286404016662 DNA binding residues [nucleotide binding] 1286404016663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404016664 Integrase core domain; Region: rve; pfam00665 1286404016665 transposase/IS protein; Provisional; Region: PRK09183 1286404016666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404016667 Walker A motif; other site 1286404016668 ATP binding site [chemical binding]; other site 1286404016669 Walker B motif; other site 1286404016670 arginine finger; other site 1286404016671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016672 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 1286404016673 active site 1286404016674 catalytic triad [active] 1286404016675 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1286404016676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404016677 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016678 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404016679 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404016680 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1286404016681 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1286404016682 active site 1286404016683 nucleophile elbow; other site 1286404016684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016685 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404016686 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016687 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016688 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1286404016689 short chain dehydrogenase; Provisional; Region: PRK12747 1286404016690 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1286404016691 NADP binding site [chemical binding]; other site 1286404016692 homodimer interface [polypeptide binding]; other site 1286404016693 active site 1286404016694 substrate binding site [chemical binding]; other site 1286404016695 EamA-like transporter family; Region: EamA; pfam00892 1286404016696 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404016697 EamA-like transporter family; Region: EamA; pfam00892 1286404016698 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404016699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404016700 DNA-binding site [nucleotide binding]; DNA binding site 1286404016701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404016702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404016703 homodimer interface [polypeptide binding]; other site 1286404016704 catalytic residue [active] 1286404016705 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 1286404016706 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1286404016707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404016708 putative substrate translocation pore; other site 1286404016709 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1286404016710 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1286404016711 active site 1286404016712 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1286404016713 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286404016714 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286404016715 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1286404016716 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1286404016717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1286404016718 NAD(P) binding site [chemical binding]; other site 1286404016719 active site 1286404016720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404016721 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286404016722 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1286404016723 spore coat protein YutH; Region: spore_yutH; TIGR02905 1286404016724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1286404016725 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1286404016726 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1286404016727 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1286404016728 active site 1286404016729 ATP binding site [chemical binding]; other site 1286404016730 spore coat protein YutH; Region: spore_yutH; TIGR02905 1286404016731 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1286404016732 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286404016733 IHF dimer interface [polypeptide binding]; other site 1286404016734 IHF - DNA interface [nucleotide binding]; other site 1286404016735 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1286404016736 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1286404016737 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1286404016738 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1286404016739 dimer interface [polypeptide binding]; other site 1286404016740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404016741 catalytic residue [active] 1286404016742 ParB-like nuclease domain; Region: ParBc; pfam02195 1286404016743 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1286404016744 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1286404016745 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404016746 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404016747 acyl-activating enzyme (AAE) consensus motif; other site 1286404016748 AMP binding site [chemical binding]; other site 1286404016749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404016750 Condensation domain; Region: Condensation; pfam00668 1286404016751 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404016752 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404016753 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404016754 acyl-activating enzyme (AAE) consensus motif; other site 1286404016755 AMP binding site [chemical binding]; other site 1286404016756 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404016757 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1286404016758 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1286404016759 acyl-activating enzyme (AAE) consensus motif; other site 1286404016760 active site 1286404016761 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1286404016762 Condensation domain; Region: Condensation; pfam00668 1286404016763 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404016764 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404016765 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404016766 acyl-activating enzyme (AAE) consensus motif; other site 1286404016767 AMP binding site [chemical binding]; other site 1286404016768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404016769 Condensation domain; Region: Condensation; pfam00668 1286404016770 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404016771 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404016772 acyl-activating enzyme (AAE) consensus motif; other site 1286404016773 AMP binding site [chemical binding]; other site 1286404016774 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404016775 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1286404016776 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1286404016777 active site 1286404016778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404016779 putative transporter; Provisional; Region: PRK10054 1286404016780 putative substrate translocation pore; other site 1286404016781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016782 putative DNA binding site [nucleotide binding]; other site 1286404016783 putative Zn2+ binding site [ion binding]; other site 1286404016784 EamA-like transporter family; Region: EamA; pfam00892 1286404016785 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1286404016786 FCD domain; Region: FCD; pfam07729 1286404016787 EamA-like transporter family; Region: EamA; pfam00892 1286404016788 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1286404016789 EamA-like transporter family; Region: EamA; pfam00892 1286404016790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404016791 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404016792 Probable transposase; Region: OrfB_IS605; pfam01385 1286404016793 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404016794 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1286404016795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404016796 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404016797 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404016798 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 1286404016799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404016800 FeS/SAM binding site; other site 1286404016801 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1286404016802 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1286404016803 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404016804 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1286404016805 IHF dimer interface [polypeptide binding]; other site 1286404016806 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1286404016807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404016808 putative substrate translocation pore; other site 1286404016809 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404016810 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404016811 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1286404016812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404016813 putative DNA binding site [nucleotide binding]; other site 1286404016814 putative Zn2+ binding site [ion binding]; other site 1286404016815 AsnC family; Region: AsnC_trans_reg; pfam01037 1286404016816 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1286404016817 EamA-like transporter family; Region: EamA; pfam00892 1286404016818 EamA-like transporter family; Region: EamA; pfam00892 1286404016819 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1286404016820 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1286404016821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016822 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404016823 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404016824 putative active site [active] 1286404016825 putative NTP binding site [chemical binding]; other site 1286404016826 putative nucleic acid binding site [nucleotide binding]; other site 1286404016827 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286404016828 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016829 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1286404016830 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1286404016831 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1286404016832 DNA binding residues [nucleotide binding] 1286404016833 dimer interface [polypeptide binding]; other site 1286404016834 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1286404016835 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404016836 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404016837 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1286404016838 homodimer interface [polypeptide binding]; other site 1286404016839 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1286404016840 active site 1286404016841 TDP-binding site; other site 1286404016842 acceptor substrate-binding pocket; other site 1286404016843 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1286404016844 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404016845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016846 DNA polymerase IV; Reviewed; Region: PRK03103 1286404016847 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1286404016848 active site 1286404016849 DNA binding site [nucleotide binding] 1286404016850 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1286404016851 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1286404016852 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1286404016853 Ligand Binding Site [chemical binding]; other site 1286404016854 Molecular Tunnel; other site 1286404016855 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016856 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1286404016857 active site 1286404016858 dimer interface [polypeptide binding]; other site 1286404016859 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1286404016860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1286404016861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1286404016862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1286404016863 dimerization interface [polypeptide binding]; other site 1286404016864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1286404016865 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1286404016866 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1286404016867 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1286404016868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1286404016869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1286404016870 Coenzyme A binding pocket [chemical binding]; other site 1286404016871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1286404016872 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1286404016873 MarR family; Region: MarR; pfam01047 1286404016874 Predicted membrane protein [Function unknown]; Region: COG2364 1286404016875 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1286404016876 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1286404016877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1286404016878 DNA-binding site [nucleotide binding]; DNA binding site 1286404016879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1286404016880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404016881 homodimer interface [polypeptide binding]; other site 1286404016882 catalytic residue [active] 1286404016883 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1286404016884 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1286404016885 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1286404016886 inhibitor site; inhibition site 1286404016887 active site 1286404016888 dimer interface [polypeptide binding]; other site 1286404016889 catalytic residue [active] 1286404016890 amino acid transporter; Region: 2A0306; TIGR00909 1286404016891 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1286404016892 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1286404016893 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1286404016894 Predicted transcriptional regulators [Transcription]; Region: COG1378 1286404016895 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1286404016896 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1286404016897 C-terminal domain interface [polypeptide binding]; other site 1286404016898 sugar binding site [chemical binding]; other site 1286404016899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1286404016900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1286404016901 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1286404016902 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1286404016903 catalytic residues [active] 1286404016904 Predicted membrane protein [Function unknown]; Region: COG2311 1286404016905 Protein of unknown function (DUF418); Region: DUF418; cl12135 1286404016906 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1286404016907 CAAX protease self-immunity; Region: Abi; pfam02517 1286404016908 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1286404016909 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404016910 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404016911 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404016912 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404016913 MarR family; Region: MarR_2; pfam12802 1286404016914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404016915 TPR motif; other site 1286404016916 binding surface 1286404016917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404016918 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 1286404016919 Replication initiation factor; Region: Rep_trans; pfam02486 1286404016920 hypothetical protein; Region: PHA00547 1286404016921 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286404016922 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404016923 Interdomain contacts; other site 1286404016924 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1286404016925 Interdomain contacts; other site 1286404016926 Cytokine receptor motif; other site 1286404016927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404016928 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1286404016929 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1286404016930 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404016931 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1286404016932 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404016933 active site 1286404016934 catalytic residues [active] 1286404016935 DNA binding site [nucleotide binding] 1286404016936 Int/Topo IB signature motif; other site 1286404016937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016938 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016939 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1286404016940 delta endotoxin; Region: Endotoxin_M; pfam00555 1286404016941 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1286404016942 putative metal binding site [ion binding]; other site 1286404016943 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404016944 amidase catalytic site [active] 1286404016945 Zn binding residues [ion binding]; other site 1286404016946 substrate binding site [chemical binding]; other site 1286404016947 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1286404016948 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1286404016949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404016950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404016951 Integrase core domain; Region: rve; pfam00665 1286404016952 transposase/IS protein; Provisional; Region: PRK09183 1286404016953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404016954 Walker A motif; other site 1286404016955 ATP binding site [chemical binding]; other site 1286404016956 Walker B motif; other site 1286404016957 arginine finger; other site 1286404016958 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404016959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404016960 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404016961 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1286404016962 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404016963 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404016964 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1286404016965 AAA-like domain; Region: AAA_10; pfam12846 1286404016966 TcpE family; Region: TcpE; pfam12648 1286404016967 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1286404016968 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404016969 AAA-like domain; Region: AAA_10; pfam12846 1286404016970 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1286404016971 MARCKS family; Region: MARCKS; pfam02063 1286404016972 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 1286404016973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1286404016974 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1286404016975 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1286404016976 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1286404016977 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286404016978 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404016979 Walker A motif; other site 1286404016980 ATP binding site [chemical binding]; other site 1286404016981 Walker B motif; other site 1286404016982 AAA domain; Region: AAA_31; pfam13614 1286404016983 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1286404016984 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286404016985 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1286404016986 S-layer homology domain; Region: SLH; pfam00395 1286404016987 S-layer homology domain; Region: SLH; pfam00395 1286404016988 S-layer homology domain; Region: SLH; pfam00395 1286404016989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404016990 non-specific DNA binding site [nucleotide binding]; other site 1286404016991 salt bridge; other site 1286404016992 sequence-specific DNA binding site [nucleotide binding]; other site 1286404016993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404016994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404016995 sequence-specific DNA binding site [nucleotide binding]; other site 1286404016996 salt bridge; other site 1286404016997 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404016998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404016999 non-specific DNA binding site [nucleotide binding]; other site 1286404017000 salt bridge; other site 1286404017001 sequence-specific DNA binding site [nucleotide binding]; other site 1286404017002 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1286404017003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1286404017004 active site 1286404017005 phosphorylation site [posttranslational modification] 1286404017006 intermolecular recognition site; other site 1286404017007 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1286404017008 DNA binding residues [nucleotide binding] 1286404017009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1286404017010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1286404017011 ATP binding site [chemical binding]; other site 1286404017012 Mg2+ binding site [ion binding]; other site 1286404017013 G-X-G motif; other site 1286404017014 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1286404017015 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1286404017016 transposase/IS protein; Provisional; Region: PRK09183 1286404017017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404017018 Walker A motif; other site 1286404017019 ATP binding site [chemical binding]; other site 1286404017020 Walker B motif; other site 1286404017021 arginine finger; other site 1286404017022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404017023 Integrase core domain; Region: rve; pfam00665 1286404017024 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404017025 Mg binding site [ion binding]; other site 1286404017026 nucleotide binding site [chemical binding]; other site 1286404017027 putative protofilament interface [polypeptide binding]; other site 1286404017028 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1286404017029 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1286404017030 active site 1286404017031 catalytic residues [active] 1286404017032 DNA binding site [nucleotide binding] 1286404017033 Int/Topo IB signature motif; other site 1286404017034 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404017035 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404017036 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404017037 putative active site [active] 1286404017038 putative NTP binding site [chemical binding]; other site 1286404017039 putative nucleic acid binding site [nucleotide binding]; other site 1286404017040 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286404017041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404017042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1286404017043 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1286404017044 delta endotoxin; Region: Endotoxin_M; pfam00555 1286404017045 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1286404017046 putative metal binding site [ion binding]; other site 1286404017047 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1286404017048 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1286404017049 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404017050 active site 1286404017051 DNA binding site [nucleotide binding] 1286404017052 Int/Topo IB signature motif; other site 1286404017053 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1286404017054 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1286404017055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404017056 active site 1286404017057 DNA binding site [nucleotide binding] 1286404017058 Int/Topo IB signature motif; other site 1286404017059 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1286404017060 IHF dimer interface [polypeptide binding]; other site 1286404017061 IHF - DNA interface [nucleotide binding]; other site 1286404017062 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1286404017063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404017064 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404017065 Probable transposase; Region: OrfB_IS605; pfam01385 1286404017066 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1286404017067 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 1286404017068 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1286404017069 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1286404017070 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1286404017071 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1286404017072 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1286404017073 shikimate binding site; other site 1286404017074 NAD(P) binding site [chemical binding]; other site 1286404017075 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286404017076 Archaeal S-adenosylmethionine synthetase [Amino acid transport and metabolism]; Region: MetK; COG1812 1286404017077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1286404017078 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1286404017079 active site 1286404017080 nucleotide-binding site [chemical binding]; other site 1286404017081 metal-binding site [ion binding] 1286404017082 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1286404017083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1286404017084 active site 1286404017085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404017086 putative substrate translocation pore; other site 1286404017087 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017088 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404017089 acyl-activating enzyme (AAE) consensus motif; other site 1286404017090 AMP binding site [chemical binding]; other site 1286404017091 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017092 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1286404017093 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1286404017094 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1286404017095 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1286404017096 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1286404017097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1286404017098 active site 1286404017099 Int/Topo IB signature motif; other site 1286404017100 DNA binding site [nucleotide binding] 1286404017101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404017102 Integrase core domain; Region: rve; pfam00665 1286404017103 transposase/IS protein; Provisional; Region: PRK09183 1286404017104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404017105 Walker A motif; other site 1286404017106 ATP binding site [chemical binding]; other site 1286404017107 Walker B motif; other site 1286404017108 arginine finger; other site 1286404017109 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1286404017110 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1286404017111 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1286404017112 NlpC/P60 family; Region: NLPC_P60; pfam00877 1286404017113 Domain of unknown function DUF87; Region: DUF87; pfam01935 1286404017114 AAA-like domain; Region: AAA_10; pfam12846 1286404017115 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1286404017116 Mg binding site [ion binding]; other site 1286404017117 nucleotide binding site [chemical binding]; other site 1286404017118 putative protofilament interface [polypeptide binding]; other site 1286404017119 MobA/MobL family; Region: MobA_MobL; pfam03389 1286404017120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404017121 ATP binding site [chemical binding]; other site 1286404017122 Walker B motif; other site 1286404017123 DNA topoisomerase III; Provisional; Region: PRK07726 1286404017124 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1286404017125 active site 1286404017126 putative interdomain interaction site [polypeptide binding]; other site 1286404017127 putative metal-binding site [ion binding]; other site 1286404017128 putative nucleotide binding site [chemical binding]; other site 1286404017129 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1286404017130 domain I; other site 1286404017131 DNA binding groove [nucleotide binding] 1286404017132 phosphate binding site [ion binding]; other site 1286404017133 domain II; other site 1286404017134 domain III; other site 1286404017135 nucleotide binding site [chemical binding]; other site 1286404017136 catalytic site [active] 1286404017137 domain IV; other site 1286404017138 AAA domain; Region: AAA_31; pfam13614 1286404017139 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286404017140 AAA domain; Region: AAA_31; pfam13614 1286404017141 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286404017142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404017143 Walker A motif; other site 1286404017144 ATP binding site [chemical binding]; other site 1286404017145 Walker B motif; other site 1286404017146 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404017147 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404017148 CARDB; Region: CARDB; pfam07705 1286404017149 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1286404017150 putative active site [active] 1286404017151 catalytic site [active] 1286404017152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404017153 binding surface 1286404017154 TPR motif; other site 1286404017155 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1286404017156 putative active site [active] 1286404017157 chaperone protein DnaJ; Provisional; Region: PRK14279 1286404017158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1286404017159 dimerization interface [polypeptide binding]; other site 1286404017160 putative DNA binding site [nucleotide binding]; other site 1286404017161 putative Zn2+ binding site [ion binding]; other site 1286404017162 Helix-turn-helix domain; Region: HTH_17; pfam12728 1286404017163 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1286404017164 S-layer homology domain; Region: SLH; pfam00395 1286404017165 S-layer homology domain; Region: SLH; pfam00395 1286404017166 S-layer homology domain; Region: SLH; pfam00395 1286404017167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404017168 non-specific DNA binding site [nucleotide binding]; other site 1286404017169 salt bridge; other site 1286404017170 sequence-specific DNA binding site [nucleotide binding]; other site 1286404017171 MAEBL; Provisional; Region: PTZ00121 1286404017172 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1286404017173 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1286404017174 catalytic residues [active] 1286404017175 catalytic nucleophile [active] 1286404017176 Presynaptic Site I dimer interface [polypeptide binding]; other site 1286404017177 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1286404017178 Synaptic Flat tetramer interface [polypeptide binding]; other site 1286404017179 Synaptic Site I dimer interface [polypeptide binding]; other site 1286404017180 DNA binding site [nucleotide binding] 1286404017181 Helix-turn-helix domain; Region: HTH_17; cl17695 1286404017182 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1286404017183 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 1286404017184 YolD-like protein; Region: YolD; pfam08863 1286404017185 PAS domain S-box; Region: sensory_box; TIGR00229 1286404017186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1286404017187 putative active site [active] 1286404017188 heme pocket [chemical binding]; other site 1286404017189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1286404017190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1286404017191 metal binding site [ion binding]; metal-binding site 1286404017192 active site 1286404017193 I-site; other site 1286404017194 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1286404017195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404017196 Integrase core domain; Region: rve; pfam00665 1286404017197 transposase/IS protein; Provisional; Region: PRK09183 1286404017198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404017199 Walker A motif; other site 1286404017200 ATP binding site [chemical binding]; other site 1286404017201 Walker B motif; other site 1286404017202 arginine finger; other site 1286404017203 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1286404017204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1286404017205 TPR motif; other site 1286404017206 binding surface 1286404017207 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 1286404017208 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1286404017209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404017210 Walker A/P-loop; other site 1286404017211 ATP binding site [chemical binding]; other site 1286404017212 Q-loop/lid; other site 1286404017213 ABC transporter signature motif; other site 1286404017214 Walker B; other site 1286404017215 D-loop; other site 1286404017216 H-loop/switch region; other site 1286404017217 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1286404017218 Peptidase C39 family; Region: Peptidase_C39; pfam03412 1286404017219 putative active site [active] 1286404017220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404017221 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1286404017222 Walker A/P-loop; other site 1286404017223 ATP binding site [chemical binding]; other site 1286404017224 Q-loop/lid; other site 1286404017225 ABC transporter signature motif; other site 1286404017226 Walker B; other site 1286404017227 D-loop; other site 1286404017228 H-loop/switch region; other site 1286404017229 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1286404017230 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1286404017231 active site 1286404017232 zinc binding site [ion binding]; other site 1286404017233 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 1286404017234 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 1286404017235 ParB-like nuclease domain; Region: ParBc; pfam02195 1286404017236 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1286404017237 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1286404017238 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286404017239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1286404017240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404017241 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404017242 Probable transposase; Region: OrfB_IS605; pfam01385 1286404017243 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404017244 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1286404017245 catalytic residue [active] 1286404017246 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 1286404017247 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1286404017248 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1286404017249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1286404017250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1286404017251 putative substrate translocation pore; other site 1286404017252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1286404017253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1286404017254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1286404017255 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1286404017256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404017257 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1286404017258 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1286404017259 inhibitor-cofactor binding pocket; inhibition site 1286404017260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1286404017261 catalytic residue [active] 1286404017262 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1286404017263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1286404017264 DNA binding site [nucleotide binding] 1286404017265 domain linker motif; other site 1286404017266 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1286404017267 putative dimerization interface [polypeptide binding]; other site 1286404017268 putative ligand binding site [chemical binding]; other site 1286404017269 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1286404017270 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1286404017271 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017272 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404017273 acyl-activating enzyme (AAE) consensus motif; other site 1286404017274 AMP binding site [chemical binding]; other site 1286404017275 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017276 Condensation domain; Region: Condensation; pfam00668 1286404017277 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017278 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404017279 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017280 acyl-activating enzyme (AAE) consensus motif; other site 1286404017281 AMP binding site [chemical binding]; other site 1286404017282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017283 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1286404017284 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1286404017285 Condensation domain; Region: Condensation; pfam00668 1286404017286 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017287 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404017288 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017289 acyl-activating enzyme (AAE) consensus motif; other site 1286404017290 AMP binding site [chemical binding]; other site 1286404017291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017292 Condensation domain; Region: Condensation; pfam00668 1286404017293 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1286404017294 FkbH-like domain; Region: FkbH; TIGR01686 1286404017295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1286404017296 active site 1286404017297 motif I; other site 1286404017298 motif II; other site 1286404017299 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1286404017300 Beta-lactamase; Region: Beta-lactamase; pfam00144 1286404017301 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cd03493 1286404017302 Iron-sulfur protein interface; other site 1286404017303 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1286404017304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404017305 Walker A/P-loop; other site 1286404017306 ATP binding site [chemical binding]; other site 1286404017307 Q-loop/lid; other site 1286404017308 ABC transporter signature motif; other site 1286404017309 Walker B; other site 1286404017310 D-loop; other site 1286404017311 H-loop/switch region; other site 1286404017312 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1286404017313 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1286404017314 Condensation domain; Region: Condensation; pfam00668 1286404017315 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017316 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017317 acyl-activating enzyme (AAE) consensus motif; other site 1286404017318 AMP binding site [chemical binding]; other site 1286404017319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017320 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1286404017321 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1286404017322 active site 1286404017323 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286404017324 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1286404017325 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1286404017326 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1286404017327 putative NADP binding site [chemical binding]; other site 1286404017328 active site 1286404017329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017330 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017331 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1286404017332 acyl-activating enzyme (AAE) consensus motif; other site 1286404017333 AMP binding site [chemical binding]; other site 1286404017334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404017335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286404017336 active site 1286404017337 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1286404017338 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1286404017339 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1286404017340 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1286404017341 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1286404017342 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286404017343 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1286404017344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1286404017345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1286404017346 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1286404017347 active site 1286404017348 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1286404017349 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1286404017350 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1286404017351 putative active site [active] 1286404017352 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017353 Condensation domain; Region: Condensation; pfam00668 1286404017354 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017355 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404017356 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017357 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017358 acyl-activating enzyme (AAE) consensus motif; other site 1286404017359 AMP binding site [chemical binding]; other site 1286404017360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017361 Condensation domain; Region: Condensation; pfam00668 1286404017362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017363 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404017364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1286404017365 acyl-activating enzyme (AAE) consensus motif; other site 1286404017366 AMP binding site [chemical binding]; other site 1286404017367 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1286404017368 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1286404017369 active site 1286404017370 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1286404017371 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1286404017372 putative NADP binding site [chemical binding]; other site 1286404017373 active site 1286404017374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017375 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1286404017376 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1286404017377 active site 1286404017378 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1286404017379 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1286404017380 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1286404017381 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1286404017382 putative NADP binding site [chemical binding]; other site 1286404017383 active site 1286404017384 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1286404017385 Condensation domain; Region: Condensation; pfam00668 1286404017386 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1286404017387 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1286404017388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1286404017389 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1286404017390 Probable transposase; Region: OrfB_IS605; pfam01385 1286404017391 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1286404017392 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404017393 amidase catalytic site [active] 1286404017394 Zn binding residues [ion binding]; other site 1286404017395 substrate binding site [chemical binding]; other site 1286404017396 Bacterial SH3 domain; Region: SH3_3; pfam08239 1286404017397 Haemolysin XhlA; Region: XhlA; pfam10779 1286404017398 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1286404017399 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1286404017400 amidase catalytic site [active] 1286404017401 Zn binding residues [ion binding]; other site 1286404017402 substrate binding site [chemical binding]; other site 1286404017403 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1286404017404 Peptidase family M23; Region: Peptidase_M23; pfam01551 1286404017405 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1286404017406 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1286404017407 catalytic residue [active] 1286404017408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1286404017409 DNA binding residues [nucleotide binding] 1286404017410 Helix-turn-helix domain; Region: HTH_36; pfam13730 1286404017411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404017412 sequence-specific DNA binding site [nucleotide binding]; other site 1286404017413 salt bridge; other site 1286404017414 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1286404017415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1286404017416 non-specific DNA binding site [nucleotide binding]; other site 1286404017417 salt bridge; other site 1286404017418 sequence-specific DNA binding site [nucleotide binding]; other site 1286404017419 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1286404017420 Domain of unknown function (DUF955); Region: DUF955; cl01076 1286404017421 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1286404017422 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1286404017423 Peptidase family M28; Region: Peptidase_M28; pfam04389 1286404017424 metal binding site [ion binding]; metal-binding site 1286404017425 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1286404017426 active site 1286404017427 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 1286404017428 GIY-YIG motif/motif A; other site 1286404017429 putative active site [active] 1286404017430 putative metal binding site [ion binding]; other site 1286404017431 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1286404017432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1286404017433 ATP binding site [chemical binding]; other site 1286404017434 putative Mg++ binding site [ion binding]; other site 1286404017435 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1286404017436 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1286404017437 homodimer interface [polypeptide binding]; other site 1286404017438 chemical substrate binding site [chemical binding]; other site 1286404017439 oligomer interface [polypeptide binding]; other site 1286404017440 metal binding site [ion binding]; metal-binding site 1286404017441 HNH endonuclease; Region: HNH_2; pfam13391 1286404017442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1286404017443 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1286404017444 active site 1286404017445 8-oxo-dGMP binding site [chemical binding]; other site 1286404017446 nudix motif; other site 1286404017447 metal binding site [ion binding]; metal-binding site 1286404017448 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1286404017449 Thermolysin metallopeptidase, alpha-helical domain; Region: Peptidase_M4_C; pfam02868 1286404017450 Peptidase M60-like family; Region: M60-like; pfam13402 1286404017451 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1286404017452 sugar binding site [chemical binding]; other site 1286404017453 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1286404017454 sugar binding site [chemical binding]; other site 1286404017455 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 1286404017456 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1286404017457 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1286404017458 dimer interface [polypeptide binding]; other site 1286404017459 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1286404017460 putative CheW interface [polypeptide binding]; other site 1286404017461 Protein of unknown function DUF86; Region: DUF86; pfam01934 1286404017462 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1286404017463 active site 1286404017464 NTP binding site [chemical binding]; other site 1286404017465 metal binding triad [ion binding]; metal-binding site 1286404017466 antibiotic binding site [chemical binding]; other site 1286404017467 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1286404017468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1286404017469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404017470 Walker A/P-loop; other site 1286404017471 ATP binding site [chemical binding]; other site 1286404017472 Q-loop/lid; other site 1286404017473 ABC transporter signature motif; other site 1286404017474 Walker B; other site 1286404017475 D-loop; other site 1286404017476 H-loop/switch region; other site 1286404017477 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1286404017478 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1286404017479 active site 1286404017480 zinc binding site [ion binding]; other site 1286404017481 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1286404017482 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1286404017483 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1286404017484 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1286404017485 active site 1286404017486 catalytic residues [active] 1286404017487 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1286404017488 putative active site [active] 1286404017489 putative catalytic triad [active] 1286404017490 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1286404017491 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1286404017492 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1286404017493 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1286404017494 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404017495 FtsX-like permease family; Region: FtsX; pfam02687 1286404017496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1286404017497 FtsX-like permease family; Region: FtsX; pfam02687 1286404017498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1286404017499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1286404017500 ABC transporter signature motif; other site 1286404017501 Walker B; other site 1286404017502 D-loop; other site 1286404017503 H-loop/switch region; other site 1286404017504 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404017505 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404017506 putative active site [active] 1286404017507 putative NTP binding site [chemical binding]; other site 1286404017508 putative nucleic acid binding site [nucleotide binding]; other site 1286404017509 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404017510 active site 1286404017511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1286404017512 Q-loop/lid; other site 1286404017513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404017514 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1286404017515 FeS/SAM binding site; other site 1286404017516 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1286404017517 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 1286404017518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1286404017519 FeS/SAM binding site; other site 1286404017520 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1286404017521 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 1286404017522 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1286404017523 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1286404017524 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1286404017525 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404017526 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404017527 putative active site [active] 1286404017528 putative NTP binding site [chemical binding]; other site 1286404017529 putative nucleic acid binding site [nucleotide binding]; other site 1286404017530 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1286404017531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404017532 active site 1286404017533 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1286404017534 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404017535 putative active site [active] 1286404017536 putative NTP binding site [chemical binding]; other site 1286404017537 putative nucleic acid binding site [nucleotide binding]; other site 1286404017538 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404017539 Type II intron maturase; Region: Intron_maturas2; pfam01348 1286404017540 Replication-relaxation; Region: Replic_Relax; pfam13814 1286404017541 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1286404017542 nucleotide binding site [chemical binding]; other site 1286404017543 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1286404017544 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1286404017545 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1286404017546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1286404017547 Walker A motif; other site 1286404017548 ATP binding site [chemical binding]; other site 1286404017549 Walker B motif; other site 1286404017550 arginine finger; other site 1286404017551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1286404017552 Integrase core domain; Region: rve; pfam00665 1286404017553 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 1286404017554 S-layer homology domain; Region: SLH; pfam00395 1286404017555 S-layer homology domain; Region: SLH; pfam00395 1286404017556 S-layer homology domain; Region: SLH; pfam00395 1286404017557 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1286404017558 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1286404017559 AAA domain; Region: AAA_31; pfam13614 1286404017560 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1286404017561 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1286404017562 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1286404017563 Walker A motif; other site 1286404017564 ATP binding site [chemical binding]; other site 1286404017565 Walker B motif; other site 1286404017566 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1286404017567 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1286404017568 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1286404017569 Recombination protein U; Region: RecU; pfam03838 1286404017570 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1286404017571 Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083 1286404017572 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1286404017573 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1286404017574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1286404017575 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404017576 Helix-turn-helix domain; Region: HTH_28; pfam13518 1286404017577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1286404017578 HTH-like domain; Region: HTH_21; pfam13276 1286404017579 Integrase core domain; Region: rve; pfam00665 1286404017580 Integrase core domain; Region: rve_2; pfam13333 1286404017581 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1286404017582 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1286404017583 active site 1286404017584 catalytic site [active] 1286404017585 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1286404017586 Recombination protein U; Region: RecU; cl01314 1286404017587 Recombination protein U; Region: RecU; cl01314 1286404017588 PrgI family protein; Region: PrgI; pfam12666 1286404017589 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1286404017590 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1286404017591 putative active site [active] 1286404017592 putative NTP binding site [chemical binding]; other site 1286404017593 putative nucleic acid binding site [nucleotide binding]; other site 1286404017594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1286404017595 active site 1286404017596 AAA-like domain; Region: AAA_10; pfam12846 1286404017597 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610