-- dump date   	20140618_235359
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
541229000001	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
541229000002	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
541229000003	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229000004	active site
541229000005	catalytic residues [active]
541229000006	DNA binding site [nucleotide binding]
541229000007	Int/Topo IB signature motif; other site
541229000008	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
541229000009	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
541229000010	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000011	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
541229000012	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
541229000013	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
541229000014	DNA binding residues [nucleotide binding]
541229000015	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
541229000016	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
541229000017	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229000018	active site
541229000019	catalytic residues [active]
541229000020	DNA binding site [nucleotide binding]
541229000021	Int/Topo IB signature motif; other site
541229000022	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
541229000023	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
541229000024	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000025	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000026	putative active site [active]
541229000027	putative NTP binding site [chemical binding]; other site
541229000028	putative nucleic acid binding site [nucleotide binding]; other site
541229000029	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
541229000030	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000031	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000032	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
541229000033	delta endotoxin; Region: Endotoxin_M; pfam00555
541229000034	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
541229000035	putative metal binding site [ion binding]; other site
541229000036	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
541229000037	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
541229000038	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000039	active site
541229000040	DNA binding site [nucleotide binding]
541229000041	Int/Topo IB signature motif; other site
541229000042	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
541229000043	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
541229000044	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000045	active site
541229000046	DNA binding site [nucleotide binding]
541229000047	Int/Topo IB signature motif; other site
541229000048	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
541229000049	IHF dimer interface [polypeptide binding]; other site
541229000050	IHF - DNA interface [nucleotide binding]; other site
541229000051	Transposase IS200 like; Region: Y1_Tnp; pfam01797
541229000052	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229000053	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229000054	Probable transposase; Region: OrfB_IS605; pfam01385
541229000055	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
541229000056	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
541229000057	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
541229000058	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
541229000059	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
541229000060	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
541229000061	shikimate binding site; other site
541229000062	NAD(P) binding site [chemical binding]; other site
541229000063	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
541229000064	Archaeal S-adenosylmethionine synthetase [Amino acid transport and metabolism]; Region: MetK; COG1812
541229000065	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
541229000066	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
541229000067	active site
541229000068	nucleotide-binding site [chemical binding]; other site
541229000069	metal-binding site [ion binding]
541229000070	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229000071	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229000072	active site
541229000073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229000074	putative substrate translocation pore; other site
541229000075	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229000076	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
541229000077	acyl-activating enzyme (AAE) consensus motif; other site
541229000078	AMP binding site [chemical binding]; other site
541229000079	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229000080	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
541229000081	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
541229000082	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
541229000083	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
541229000084	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
541229000085	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000086	active site
541229000087	Int/Topo IB signature motif; other site
541229000088	DNA binding site [nucleotide binding]
541229000089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229000090	Integrase core domain; Region: rve; pfam00665
541229000091	transposase/IS protein; Provisional; Region: PRK09183
541229000092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000093	Walker A motif; other site
541229000094	ATP binding site [chemical binding]; other site
541229000095	Walker B motif; other site
541229000096	arginine finger; other site
541229000097	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229000098	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
541229000099	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229000100	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229000101	AAA-like domain; Region: AAA_10; pfam12846
541229000102	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000103	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000104	putative active site [active]
541229000105	putative NTP binding site [chemical binding]; other site
541229000106	putative nucleic acid binding site [nucleotide binding]; other site
541229000107	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000108	active site
541229000109	AAA-like domain; Region: AAA_10; pfam12846
541229000110	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
541229000111	Mg binding site [ion binding]; other site
541229000112	nucleotide binding site [chemical binding]; other site
541229000113	putative protofilament interface [polypeptide binding]; other site
541229000114	MobA/MobL family; Region: MobA_MobL; pfam03389
541229000115	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000116	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000117	putative active site [active]
541229000118	putative NTP binding site [chemical binding]; other site
541229000119	putative nucleic acid binding site [nucleotide binding]; other site
541229000120	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000121	active site
541229000122	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
541229000123	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
541229000124	DNA topoisomerase III; Provisional; Region: PRK07726
541229000125	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
541229000126	active site
541229000127	putative interdomain interaction site [polypeptide binding]; other site
541229000128	putative metal-binding site [ion binding]; other site
541229000129	putative nucleotide binding site [chemical binding]; other site
541229000130	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
541229000131	domain I; other site
541229000132	DNA binding groove [nucleotide binding]
541229000133	phosphate binding site [ion binding]; other site
541229000134	domain II; other site
541229000135	domain III; other site
541229000136	nucleotide binding site [chemical binding]; other site
541229000137	catalytic site [active]
541229000138	domain IV; other site
541229000139	AAA domain; Region: AAA_31; pfam13614
541229000140	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
541229000141	AAA domain; Region: AAA_31; pfam13614
541229000142	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
541229000143	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229000144	Walker A motif; other site
541229000145	ATP binding site [chemical binding]; other site
541229000146	Walker B motif; other site
541229000147	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229000148	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229000149	CARDB; Region: CARDB; pfam07705
541229000150	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
541229000151	putative active site [active]
541229000152	catalytic site [active]
541229000153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229000154	binding surface
541229000155	TPR motif; other site
541229000156	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
541229000157	putative active site [active]
541229000158	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229000159	dimerization interface [polypeptide binding]; other site
541229000160	putative DNA binding site [nucleotide binding]; other site
541229000161	putative Zn2+ binding site [ion binding]; other site
541229000162	Helix-turn-helix domain; Region: HTH_17; pfam12728
541229000163	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
541229000164	S-layer homology domain; Region: SLH; pfam00395
541229000165	S-layer homology domain; Region: SLH; pfam00395
541229000166	S-layer homology domain; Region: SLH; pfam00395
541229000167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000168	non-specific DNA binding site [nucleotide binding]; other site
541229000169	salt bridge; other site
541229000170	sequence-specific DNA binding site [nucleotide binding]; other site
541229000171	potential frameshift: common BLAST hit: gi|208701934|ref|YP_002267220.1| proline-rich protein
541229000172	CryBP1 protein; Region: CryBP1; pfam07029
541229000173	Holin family; Region: Phage_holin_4; pfam05105
541229000174	N-acetyltransferase; Region: Acetyltransf_2; cl00949
541229000175	N-acetyltransferase; Region: Acetyltransf_2; cl00949
541229000176	Fic family protein [Function unknown]; Region: COG3177
541229000177	Fic/DOC family; Region: Fic; pfam02661
541229000178	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229000179	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
541229000180	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229000181	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229000182	Probable transposase; Region: OrfB_IS605; pfam01385
541229000183	Transposase IS200 like; Region: Y1_Tnp; pfam01797
541229000184	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
541229000185	N-acetyltransferase; Region: Acetyltransf_2; cl00949
541229000186	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
541229000187	conformational flexibility of ligand binding pocket; other site
541229000188	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
541229000189	active site
541229000190	ADP-ribosylating toxin turn-turn motif; other site
541229000191	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000192	EamA-like transporter family; Region: EamA; pfam00892
541229000193	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229000194	EamA-like transporter family; Region: EamA; pfam00892
541229000195	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229000196	dimerization interface [polypeptide binding]; other site
541229000197	putative DNA binding site [nucleotide binding]; other site
541229000198	putative Zn2+ binding site [ion binding]; other site
541229000199	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229000200	SEC-C motif; Region: SEC-C; pfam02810
541229000201	Flagellin N-methylase; Region: FliB; pfam03692
541229000202	transposase/IS protein; Provisional; Region: PRK09183
541229000203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000204	Walker A motif; other site
541229000205	ATP binding site [chemical binding]; other site
541229000206	Walker B motif; other site
541229000207	arginine finger; other site
541229000208	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229000209	Integrase core domain; Region: rve; pfam00665
541229000210	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
541229000211	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
541229000212	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229000213	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
541229000214	Helix-turn-helix domain; Region: HTH_17; pfam12728
541229000215	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000216	active site
541229000217	Int/Topo IB signature motif; other site
541229000218	DNA binding site [nucleotide binding]
541229000219	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229000220	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000221	non-specific DNA binding site [nucleotide binding]; other site
541229000222	salt bridge; other site
541229000223	sequence-specific DNA binding site [nucleotide binding]; other site
541229000224	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229000225	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229000226	peptide binding site [polypeptide binding]; other site
541229000227	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
541229000228	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229000229	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
541229000230	IHF dimer interface [polypeptide binding]; other site
541229000231	IHF - DNA interface [nucleotide binding]; other site
541229000232	alanyl-tRNA synthetase; Provisional; Region: PRK01584
541229000233	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000234	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000235	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
541229000236	DNA polymerase IV; Reviewed; Region: PRK03103
541229000237	active site
541229000238	DNA binding site [nucleotide binding]
541229000239	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
541229000240	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
541229000241	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000242	active site
541229000243	DNA binding site [nucleotide binding]
541229000244	Int/Topo IB signature motif; other site
541229000245	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000246	active site
541229000247	DNA binding site [nucleotide binding]
541229000248	Int/Topo IB signature motif; other site
541229000249	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
541229000250	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229000251	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
541229000252	YolD-like protein; Region: YolD; pfam08863
541229000253	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
541229000254	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229000255	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229000256	DNA binding residues [nucleotide binding]
541229000257	Putative zinc-finger; Region: zf-HC2; pfam13490
541229000258	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
541229000259	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229000260	EamA-like transporter family; Region: EamA; pfam00892
541229000261	EamA-like transporter family; Region: EamA; pfam00892
541229000262	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
541229000263	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229000264	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229000265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229000266	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229000267	dimerization interface [polypeptide binding]; other site
541229000268	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
541229000269	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000270	YolD-like protein; Region: YolD; pfam08863
541229000271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000272	Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443
541229000273	Walker A motif; other site
541229000274	ATP binding site [chemical binding]; other site
541229000275	Walker B motif; other site
541229000276	Family description; Region: UvrD_C_2; pfam13538
541229000277	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229000278	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
541229000279	LXG domain of WXG superfamily; Region: LXG; pfam04740
541229000280	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
541229000281	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229000282	catalytic residues [active]
541229000283	Predicted membrane protein [Function unknown]; Region: COG2311
541229000284	Protein of unknown function (DUF418); Region: DUF418; cl12135
541229000285	Protein of unknown function (DUF418); Region: DUF418; pfam04235
541229000286	CAAX protease self-immunity; Region: Abi; pfam02517
541229000287	integrase; Provisional; Region: int; PHA02601
541229000288	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
541229000289	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229000290	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229000291	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229000292	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229000293	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
541229000294	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000295	putative active site [active]
541229000296	putative NTP binding site [chemical binding]; other site
541229000297	putative nucleic acid binding site [nucleotide binding]; other site
541229000298	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000299	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000300	Type II intron maturase; Region: Intron_maturas2; pfam01348
541229000301	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
541229000302	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000303	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000304	putative active site [active]
541229000305	putative NTP binding site [chemical binding]; other site
541229000306	putative nucleic acid binding site [nucleotide binding]; other site
541229000307	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000308	active site
541229000309	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
541229000310	N-acetyl-D-glucosamine binding site [chemical binding]; other site
541229000311	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000312	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000313	putative active site [active]
541229000314	putative NTP binding site [chemical binding]; other site
541229000315	putative nucleic acid binding site [nucleotide binding]; other site
541229000316	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000317	active site
541229000318	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
541229000319	AAA-like domain; Region: AAA_10; pfam12846
541229000320	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000321	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000322	putative active site [active]
541229000323	putative NTP binding site [chemical binding]; other site
541229000324	putative nucleic acid binding site [nucleotide binding]; other site
541229000325	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000326	active site
541229000327	PrgI family protein; Region: PrgI; pfam12666
541229000328	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
541229000329	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
541229000330	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
541229000331	active site
541229000332	metal binding site [ion binding]; metal-binding site
541229000333	interdomain interaction site; other site
541229000334	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000335	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000336	putative active site [active]
541229000337	putative NTP binding site [chemical binding]; other site
541229000338	putative nucleic acid binding site [nucleotide binding]; other site
541229000339	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000340	active site
541229000341	ARID/BRIGHT DNA binding domain; Region: ARID; cl02633
541229000342	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
541229000343	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229000344	Walker A motif; other site
541229000345	ATP binding site [chemical binding]; other site
541229000346	Walker B motif; other site
541229000347	AAA domain; Region: AAA_31; pfam13614
541229000348	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
541229000349	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
541229000350	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
541229000351	S-layer homology domain; Region: SLH; pfam00395
541229000352	S-layer homology domain; Region: SLH; pfam00395
541229000353	S-layer homology domain; Region: SLH; pfam00395
541229000354	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
541229000355	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229000356	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
541229000357	DNA binding residues [nucleotide binding]
541229000358	Transcriptional regulators [Transcription]; Region: MarR; COG1846
541229000359	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
541229000360	nucleotide binding site [chemical binding]; other site
541229000361	Replication-relaxation; Region: Replic_Relax; pfam13814
541229000362	Domain of unknown function (DUF373); Region: DUF373; cl12079
541229000363	transposase/IS protein; Provisional; Region: PRK09183
541229000364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000365	Walker A motif; other site
541229000366	ATP binding site [chemical binding]; other site
541229000367	Walker B motif; other site
541229000368	arginine finger; other site
541229000369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229000370	Integrase core domain; Region: rve; pfam00665
541229000371	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000372	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000373	putative active site [active]
541229000374	putative nucleic acid binding site [nucleotide binding]; other site
541229000375	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000376	Type II intron maturase; Region: Intron_maturas2; pfam01348
541229000377	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000378	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000379	putative active site [active]
541229000380	putative NTP binding site [chemical binding]; other site
541229000381	putative nucleic acid binding site [nucleotide binding]; other site
541229000382	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
541229000383	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000384	active site
541229000385	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
541229000386	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
541229000387	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
541229000388	DNA polymerase III subunit beta; Validated; Region: PRK05643
541229000389	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
541229000390	putative DNA binding surface [nucleotide binding]; other site
541229000391	dimer interface [polypeptide binding]; other site
541229000392	beta-clamp/clamp loader binding surface; other site
541229000393	beta-clamp/translesion DNA polymerase binding surface; other site
541229000394	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
541229000395	PRTRC system protein A; Region: PRTRC_A; TIGR03735
541229000396	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
541229000397	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
541229000398	ATP binding site [chemical binding]; other site
541229000399	substrate interface [chemical binding]; other site
541229000400	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
541229000401	active site
541229000402	NTP binding site [chemical binding]; other site
541229000403	metal binding triad [ion binding]; metal-binding site
541229000404	antibiotic binding site [chemical binding]; other site
541229000405	HEPN domain; Region: HEPN; pfam05168
541229000406	hypothetical protein; Provisional; Region: PRK06850
541229000407	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
541229000408	Active Sites [active]
541229000409	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229000410	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000411	non-specific DNA binding site [nucleotide binding]; other site
541229000412	salt bridge; other site
541229000413	sequence-specific DNA binding site [nucleotide binding]; other site
541229000414	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
541229000415	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229000416	active site
541229000417	catalytic residues [active]
541229000418	DNA binding site [nucleotide binding]
541229000419	Int/Topo IB signature motif; other site
541229000420	Domain of unknown function (DUF955); Region: DUF955; pfam06114
541229000421	TPR repeat; Region: TPR_11; pfam13414
541229000422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229000423	binding surface
541229000424	TPR motif; other site
541229000425	TPR repeat; Region: TPR_11; pfam13414
541229000426	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
541229000427	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
541229000428	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
541229000429	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
541229000430	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
541229000431	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
541229000432	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
541229000433	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
541229000434	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
541229000435	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
541229000436	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
541229000437	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
541229000438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229000439	S-adenosylmethionine binding site [chemical binding]; other site
541229000440	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000441	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000442	putative active site [active]
541229000443	putative NTP binding site [chemical binding]; other site
541229000444	putative nucleic acid binding site [nucleotide binding]; other site
541229000445	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
541229000446	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
541229000447	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229000448	nucleotide binding region [chemical binding]; other site
541229000449	ATP-binding site [chemical binding]; other site
541229000450	Nuclease-related domain; Region: NERD; pfam08378
541229000451	DNA topoisomerase III; Provisional; Region: PRK07726
541229000452	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
541229000453	active site
541229000454	putative interdomain interaction site [polypeptide binding]; other site
541229000455	putative metal-binding site [ion binding]; other site
541229000456	putative nucleotide binding site [chemical binding]; other site
541229000457	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
541229000458	domain I; other site
541229000459	DNA binding groove [nucleotide binding]
541229000460	phosphate binding site [ion binding]; other site
541229000461	domain II; other site
541229000462	domain III; other site
541229000463	nucleotide binding site [chemical binding]; other site
541229000464	catalytic site [active]
541229000465	domain IV; other site
541229000466	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
541229000467	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229000468	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229000469	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229000470	Staphylococcal nuclease homologues; Region: SNc; smart00318
541229000471	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
541229000472	Catalytic site; other site
541229000473	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
541229000474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229000475	dimerization interface [polypeptide binding]; other site
541229000476	putative DNA binding site [nucleotide binding]; other site
541229000477	putative Zn2+ binding site [ion binding]; other site
541229000478	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229000479	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229000480	TPR motif; other site
541229000481	binding surface
541229000482	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
541229000483	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000484	active site
541229000485	DNA binding site [nucleotide binding]
541229000486	Int/Topo IB signature motif; other site
541229000487	N-acetyltransferase; Region: Acetyltransf_2; cl00949
541229000488	putative transposase OrfB; Reviewed; Region: PHA02517
541229000489	HTH-like domain; Region: HTH_21; pfam13276
541229000490	Integrase core domain; Region: rve; pfam00665
541229000491	Integrase core domain; Region: rve_2; pfam13333
541229000492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229000493	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229000494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229000495	Transposase; Region: HTH_Tnp_1; cl17663
541229000496	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229000497	Transposase IS200 like; Region: Y1_Tnp; pfam01797
541229000498	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229000499	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
541229000500	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229000501	Probable transposase; Region: OrfB_IS605; pfam01385
541229000502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
541229000503	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229000504	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229000505	Probable transposase; Region: OrfB_IS605; pfam01385
541229000506	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229000507	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229000508	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229000509	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229000510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
541229000511	potential frameshift: common BLAST hit: gi|163943334|ref|YP_001642564.1| integrase catalytic region
541229000512	DDE domain; Region: DDE_Tnp_IS240; pfam13610
541229000513	DDE domain; Region: DDE_Tnp_IS240; pfam13610
541229000514	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229000515	dimerization interface [polypeptide binding]; other site
541229000516	putative DNA binding site [nucleotide binding]; other site
541229000517	putative Zn2+ binding site [ion binding]; other site
541229000518	SdpI/YhfL protein family; Region: SdpI; pfam13630
541229000519	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
541229000520	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
541229000521	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
541229000522	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
541229000523	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
541229000524	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
541229000525	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
541229000526	active site
541229000527	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229000528	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229000529	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229000530	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
541229000531	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229000532	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
541229000533	dimerization interface [polypeptide binding]; other site
541229000534	substrate binding pocket [chemical binding]; other site
541229000535	Transposase domain (DUF772); Region: DUF772; pfam05598
541229000536	HTH domain; Region: HTH_11; pfam08279
541229000537	Mga helix-turn-helix domain; Region: Mga; pfam05043
541229000538	Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495
541229000539	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
541229000540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229000541	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229000542	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
541229000543	Bacillus thuringiensis delta-Endotoxin, middle domain; Region: Endotoxin_mid; pfam09131
541229000544	delta endotoxin; Region: Endotoxin_C; pfam03944
541229000545	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
541229000546	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
541229000547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229000548	dimerization interface [polypeptide binding]; other site
541229000549	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229000550	dimer interface [polypeptide binding]; other site
541229000551	putative CheW interface [polypeptide binding]; other site
541229000552	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
541229000553	TrkA-C domain; Region: TrkA_C; pfam02080
541229000554	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
541229000555	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
541229000556	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229000557	amidase catalytic site [active]
541229000558	Zn binding residues [ion binding]; other site
541229000559	substrate binding site [chemical binding]; other site
541229000560	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
541229000561	delta endotoxin; Region: Endotoxin_M; pfam00555
541229000562	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
541229000563	putative metal binding site [ion binding]; other site
541229000564	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
541229000565	delta endotoxin; Region: Endotoxin_M; pfam00555
541229000566	delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085
541229000567	putative metal binding site [ion binding]; other site
541229000568	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
541229000569	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000570	active site
541229000571	DNA binding site [nucleotide binding]
541229000572	Int/Topo IB signature motif; other site
541229000573	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
541229000574	ADP-ribose binding site [chemical binding]; other site
541229000575	delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945
541229000576	Bacillus thuringiensis delta-Endotoxin, middle domain; Region: Endotoxin_mid; pfam09131
541229000577	delta endotoxin; Region: Endotoxin_C; pfam03944
541229000578	Phage capsid family; Region: Phage_capsid; pfam05065
541229000579	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
541229000580	Phage-related minor tail protein [Function unknown]; Region: COG5280
541229000581	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
541229000582	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
541229000583	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
541229000584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229000585	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229000586	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229000587	Holin family; Region: Phage_holin_4; cl01989
541229000588	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229000589	amidase catalytic site [active]
541229000590	Zn binding residues [ion binding]; other site
541229000591	substrate binding site [chemical binding]; other site
541229000592	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229000593	Helix-turn-helix domain; Region: HTH_17; cl17695
541229000594	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
541229000595	active site
541229000596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229000597	TPR motif; other site
541229000598	binding surface
541229000599	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
541229000600	plasmid segregation protein ParM; Provisional; Region: PRK13917
541229000601	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
541229000602	Mg binding site [ion binding]; other site
541229000603	nucleotide binding site [chemical binding]; other site
541229000604	putative protofilament interface [polypeptide binding]; other site
541229000605	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
541229000606	DNA binding residues [nucleotide binding]
541229000607	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
541229000608	Domain of unknown function (DUF955); Region: DUF955; pfam06114
541229000609	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229000610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000611	non-specific DNA binding site [nucleotide binding]; other site
541229000612	salt bridge; other site
541229000613	sequence-specific DNA binding site [nucleotide binding]; other site
541229000614	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
541229000615	sequence-specific DNA binding site [nucleotide binding]; other site
541229000616	salt bridge; other site
541229000617	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
541229000618	ORF6C domain; Region: ORF6C; pfam10552
541229000619	dUTPase; Region: dUTPase_2; pfam08761
541229000620	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
541229000621	active site
541229000622	homodimer interface [polypeptide binding]; other site
541229000623	metal binding site [ion binding]; metal-binding site
541229000624	Domain of unknown function (DUF3797); Region: DUF3797; pfam12677
541229000625	Protein involved in mRNA turnover and stability [RNA processing and modification]; Region: SSM4; COG5183
541229000626	YopX protein; Region: YopX; pfam09643
541229000627	Recombination protein U; Region: RecU; pfam03838
541229000628	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
541229000629	positive control sigma-like factor; Validated; Region: PRK06930
541229000630	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229000631	DNA binding residues [nucleotide binding]
541229000632	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000633	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000634	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
541229000635	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
541229000636	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
541229000637	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000638	active site
541229000639	DNA binding site [nucleotide binding]
541229000640	Int/Topo IB signature motif; other site
541229000641	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
541229000642	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
541229000643	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000644	active site
541229000645	DNA binding site [nucleotide binding]
541229000646	Int/Topo IB signature motif; other site
541229000647	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229000648	Walker A motif; other site
541229000649	ATP binding site [chemical binding]; other site
541229000650	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000651	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000652	putative active site [active]
541229000653	putative NTP binding site [chemical binding]; other site
541229000654	putative nucleic acid binding site [nucleotide binding]; other site
541229000655	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000656	active site
541229000657	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229000658	Walker B motif; other site
541229000659	AAA-like domain; Region: AAA_10; pfam12846
541229000660	Domain of unknown function DUF87; Region: DUF87; pfam01935
541229000661	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
541229000662	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229000663	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229000664	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229000665	S-layer homology domain; Region: SLH; pfam00395
541229000666	S-layer homology domain; Region: SLH; pfam00395
541229000667	S-layer homology domain; Region: SLH; pfam00395
541229000668	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
541229000669	AAA domain; Region: AAA_31; pfam13614
541229000670	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
541229000671	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229000672	Walker A motif; other site
541229000673	ATP binding site [chemical binding]; other site
541229000674	Walker B motif; other site
541229000675	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
541229000676	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
541229000677	YopX protein; Region: YopX; pfam09643
541229000678	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
541229000679	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
541229000680	Fic/DOC family; Region: Fic; cl00960
541229000681	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
541229000682	DNA binding residues [nucleotide binding]
541229000683	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
541229000684	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000685	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
541229000686	active site
541229000687	DNA binding site [nucleotide binding]
541229000688	Int/Topo IB signature motif; other site
541229000689	DNA topoisomerase III; Provisional; Region: PRK07726
541229000690	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
541229000691	active site
541229000692	putative interdomain interaction site [polypeptide binding]; other site
541229000693	putative metal-binding site [ion binding]; other site
541229000694	putative nucleotide binding site [chemical binding]; other site
541229000695	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
541229000696	domain I; other site
541229000697	DNA binding groove [nucleotide binding]
541229000698	phosphate binding site [ion binding]; other site
541229000699	domain II; other site
541229000700	domain III; other site
541229000701	nucleotide binding site [chemical binding]; other site
541229000702	catalytic site [active]
541229000703	domain IV; other site
541229000704	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229000705	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229000706	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229000707	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
541229000708	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229000709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
541229000710	TPR motif; other site
541229000711	binding surface
541229000712	bacterial Hfq-like; Region: Hfq; cd01716
541229000713	hexamer interface [polypeptide binding]; other site
541229000714	Sm1 motif; other site
541229000715	RNA binding site [nucleotide binding]; other site
541229000716	Sm2 motif; other site
541229000717	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229000718	transposase/IS protein; Provisional; Region: PRK09183
541229000719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000720	Walker A motif; other site
541229000721	ATP binding site [chemical binding]; other site
541229000722	Walker B motif; other site
541229000723	arginine finger; other site
541229000724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229000725	Integrase core domain; Region: rve; pfam00665
541229000726	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229000727	dimerization interface [polypeptide binding]; other site
541229000728	putative DNA binding site [nucleotide binding]; other site
541229000729	putative Zn2+ binding site [ion binding]; other site
541229000730	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229000731	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229000732	DNA binding residues [nucleotide binding]
541229000733	dimerization interface [polypeptide binding]; other site
541229000734	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
541229000735	UDP-glucoronosyl and UDP-glucosyl transferase; Region: UDPGT; pfam00201
541229000736	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
541229000737	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229000738	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
541229000739	putative active site [active]
541229000740	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
541229000741	Mg binding site [ion binding]; other site
541229000742	nucleotide binding site [chemical binding]; other site
541229000743	putative protofilament interface [polypeptide binding]; other site
541229000744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000745	non-specific DNA binding site [nucleotide binding]; other site
541229000746	salt bridge; other site
541229000747	sequence-specific DNA binding site [nucleotide binding]; other site
541229000748	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229000749	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000750	non-specific DNA binding site [nucleotide binding]; other site
541229000751	salt bridge; other site
541229000752	sequence-specific DNA binding site [nucleotide binding]; other site
541229000753	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
541229000754	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
541229000755	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229000756	active site
541229000757	catalytic residues [active]
541229000758	DNA binding site [nucleotide binding]
541229000759	Int/Topo IB signature motif; other site
541229000760	Helix-turn-helix domain; Region: HTH_17; pfam12728
541229000761	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
541229000762	Mg binding site [ion binding]; other site
541229000763	nucleotide binding site [chemical binding]; other site
541229000764	putative protofilament interface [polypeptide binding]; other site
541229000765	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229000766	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
541229000767	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
541229000768	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229000769	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229000770	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229000771	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229000772	Transcriptional regulator PadR-like family; Region: PadR; cl17335
541229000773	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
541229000774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229000775	sequence-specific DNA binding site [nucleotide binding]; other site
541229000776	salt bridge; other site
541229000777	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
541229000778	YolD-like protein; Region: YolD; pfam08863
541229000779	Protein of unknown function, DUF606; Region: DUF606; pfam04657
541229000780	Protein of unknown function, DUF606; Region: DUF606; pfam04657
541229000781	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229000782	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229000783	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
541229000784	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
541229000785	active site 2 [active]
541229000786	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
541229000787	Y-family of DNA polymerases; Region: PolY; cl12025
541229000788	active site
541229000789	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
541229000790	YueH-like protein; Region: YueH; pfam14166
541229000791	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
541229000792	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229000793	active site
541229000794	DNA binding site [nucleotide binding]
541229000795	Int/Topo IB signature motif; other site
541229000796	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229000797	Integrase core domain; Region: rve; pfam00665
541229000798	transposase/IS protein; Provisional; Region: PRK09183
541229000799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000800	Walker A motif; other site
541229000801	ATP binding site [chemical binding]; other site
541229000802	Walker B motif; other site
541229000803	arginine finger; other site
541229000804	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
541229000805	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
541229000806	active site
541229000807	ATP binding site [chemical binding]; other site
541229000808	substrate binding site [chemical binding]; other site
541229000809	activation loop (A-loop); other site
541229000810	AAA domain; Region: AAA_11; pfam13086
541229000811	Part of AAA domain; Region: AAA_19; pfam13245
541229000812	AAA domain; Region: AAA_30; pfam13604
541229000813	AAA domain; Region: AAA_12; pfam13087
541229000814	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229000815	dimerization interface [polypeptide binding]; other site
541229000816	putative DNA binding site [nucleotide binding]; other site
541229000817	putative Zn2+ binding site [ion binding]; other site
541229000818	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229000819	bacterial Hfq-like; Region: Hfq; cd01716
541229000820	hexamer interface [polypeptide binding]; other site
541229000821	Sm1 motif; other site
541229000822	RNA binding site [nucleotide binding]; other site
541229000823	Sm2 motif; other site
541229000824	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
541229000825	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229000826	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
541229000827	catalytic residues [active]
541229000828	catalytic nucleophile [active]
541229000829	Presynaptic Site I dimer interface [polypeptide binding]; other site
541229000830	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
541229000831	Synaptic Flat tetramer interface [polypeptide binding]; other site
541229000832	Synaptic Site I dimer interface [polypeptide binding]; other site
541229000833	DNA binding site [nucleotide binding]
541229000834	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
541229000835	Protein of unknown function, DUF393; Region: DUF393; pfam04134
541229000836	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
541229000837	active site
541229000838	catalytic triad [active]
541229000839	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
541229000840	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
541229000841	ATP binding site [chemical binding]; other site
541229000842	substrate interface [chemical binding]; other site
541229000843	KDPG and KHG aldolase; Region: Aldolase; cl17259
541229000844	Initiator Replication protein; Region: Rep_3; pfam01051
541229000845	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
541229000846	Putative zinc-finger; Region: zf-HC2; pfam13490
541229000847	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
541229000848	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
541229000849	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229000850	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229000851	DNA binding residues [nucleotide binding]
541229000852	conjugal transfer protein TrbE; Provisional; Region: PRK13830
541229000853	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
541229000854	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229000855	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229000856	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
541229000857	AAA-like domain; Region: AAA_10; pfam12846
541229000858	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229000859	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229000860	putative active site [active]
541229000861	putative NTP binding site [chemical binding]; other site
541229000862	putative nucleic acid binding site [nucleotide binding]; other site
541229000863	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229000864	active site
541229000865	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229000866	Walker A motif; other site
541229000867	ATP binding site [chemical binding]; other site
541229000868	TcpE family; Region: TcpE; pfam12648
541229000869	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
541229000870	Replication-relaxation; Region: Replic_Relax; pfam13814
541229000871	AAA-like domain; Region: AAA_10; pfam12846
541229000872	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
541229000873	Replication protein; Region: Rep_1; cl02412
541229000874	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
541229000875	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
541229000876	DnaA N-terminal domain; Region: DnaA_N; pfam11638
541229000877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000878	Walker A motif; other site
541229000879	ATP binding site [chemical binding]; other site
541229000880	Walker B motif; other site
541229000881	arginine finger; other site
541229000882	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
541229000883	DnaA box-binding interface [nucleotide binding]; other site
541229000884	DNA polymerase III subunit beta; Validated; Region: PRK05643
541229000885	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
541229000886	putative DNA binding surface [nucleotide binding]; other site
541229000887	dimer interface [polypeptide binding]; other site
541229000888	beta-clamp/clamp loader binding surface; other site
541229000889	beta-clamp/translesion DNA polymerase binding surface; other site
541229000890	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
541229000891	recombination protein F; Reviewed; Region: recF; PRK00064
541229000892	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
541229000893	Walker A/P-loop; other site
541229000894	ATP binding site [chemical binding]; other site
541229000895	Q-loop/lid; other site
541229000896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229000897	ABC transporter signature motif; other site
541229000898	Walker B; other site
541229000899	D-loop; other site
541229000900	H-loop/switch region; other site
541229000901	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
541229000902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229000903	Mg2+ binding site [ion binding]; other site
541229000904	G-X-G motif; other site
541229000905	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
541229000906	anchoring element; other site
541229000907	dimer interface [polypeptide binding]; other site
541229000908	ATP binding site [chemical binding]; other site
541229000909	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
541229000910	active site
541229000911	putative metal-binding site [ion binding]; other site
541229000912	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
541229000913	DNA gyrase subunit A; Validated; Region: PRK05560
541229000914	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
541229000915	CAP-like domain; other site
541229000916	active site
541229000917	primary dimer interface [polypeptide binding]; other site
541229000918	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229000919	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229000920	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229000921	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229000922	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229000923	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229000924	YaaC-like Protein; Region: YaaC; pfam14175
541229000925	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
541229000926	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
541229000927	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
541229000928	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
541229000929	active site
541229000930	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
541229000931	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229000932	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
541229000933	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
541229000934	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
541229000935	active site
541229000936	multimer interface [polypeptide binding]; other site
541229000937	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
541229000938	predicted active site [active]
541229000939	catalytic triad [active]
541229000940	seryl-tRNA synthetase; Provisional; Region: PRK05431
541229000941	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
541229000942	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
541229000943	dimer interface [polypeptide binding]; other site
541229000944	active site
541229000945	motif 1; other site
541229000946	motif 2; other site
541229000947	motif 3; other site
541229000948	Domain of unknown function (DUF3797); Region: DUF3797; pfam12677
541229000949	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229000950	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
541229000951	DNA binding residues [nucleotide binding]
541229000952	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
541229000953	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
541229000954	Substrate-binding site [chemical binding]; other site
541229000955	Substrate specificity [chemical binding]; other site
541229000956	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
541229000957	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
541229000958	Substrate-binding site [chemical binding]; other site
541229000959	Substrate specificity [chemical binding]; other site
541229000960	Isochorismatase family; Region: Isochorismatase; pfam00857
541229000961	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
541229000962	catalytic triad [active]
541229000963	conserved cis-peptide bond; other site
541229000964	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
541229000965	nucleoside/Zn binding site; other site
541229000966	dimer interface [polypeptide binding]; other site
541229000967	catalytic motif [active]
541229000968	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
541229000969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229000970	Walker A motif; other site
541229000971	ATP binding site [chemical binding]; other site
541229000972	Walker B motif; other site
541229000973	arginine finger; other site
541229000974	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
541229000975	hypothetical protein; Validated; Region: PRK00153
541229000976	recombination protein RecR; Reviewed; Region: recR; PRK00076
541229000977	RecR protein; Region: RecR; pfam02132
541229000978	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
541229000979	putative active site [active]
541229000980	putative metal-binding site [ion binding]; other site
541229000981	tetramer interface [polypeptide binding]; other site
541229000982	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
541229000983	pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862
541229000984	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
541229000985	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
541229000986	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
541229000987	homodimer interface [polypeptide binding]; other site
541229000988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229000989	catalytic residue [active]
541229000990	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
541229000991	thymidylate kinase; Validated; Region: tmk; PRK00698
541229000992	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
541229000993	TMP-binding site; other site
541229000994	ATP-binding site [chemical binding]; other site
541229000995	DNA polymerase III subunit delta'; Validated; Region: PRK08058
541229000996	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
541229000997	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
541229000998	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
541229000999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001000	S-adenosylmethionine binding site [chemical binding]; other site
541229001001	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
541229001002	putative active site [active]
541229001003	GIY-YIG motif/motif A; other site
541229001004	putative metal binding site [ion binding]; other site
541229001005	Predicted methyltransferases [General function prediction only]; Region: COG0313
541229001006	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
541229001007	putative SAM binding site [chemical binding]; other site
541229001008	putative homodimer interface [polypeptide binding]; other site
541229001009	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
541229001010	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229001011	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
541229001012	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
541229001013	active site
541229001014	HIGH motif; other site
541229001015	KMSKS motif; other site
541229001016	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
541229001017	tRNA binding surface [nucleotide binding]; other site
541229001018	anticodon binding site; other site
541229001019	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
541229001020	dimer interface [polypeptide binding]; other site
541229001021	putative tRNA-binding site [nucleotide binding]; other site
541229001022	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
541229001023	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
541229001024	active site
541229001025	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
541229001026	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
541229001027	putative active site [active]
541229001028	putative metal binding site [ion binding]; other site
541229001029	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
541229001030	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
541229001031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001032	S-adenosylmethionine binding site [chemical binding]; other site
541229001033	sporulation peptidase YabG; Region: spore_yabG; TIGR02855
541229001034	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
541229001035	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
541229001036	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
541229001037	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
541229001038	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
541229001039	pur operon repressor; Provisional; Region: PRK09213
541229001040	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
541229001041	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229001042	active site
541229001043	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
541229001044	homotrimer interaction site [polypeptide binding]; other site
541229001045	putative active site [active]
541229001046	regulatory protein SpoVG; Reviewed; Region: PRK13259
541229001047	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
541229001048	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
541229001049	Substrate binding site; other site
541229001050	Mg++ binding site; other site
541229001051	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
541229001052	active site
541229001053	substrate binding site [chemical binding]; other site
541229001054	CoA binding site [chemical binding]; other site
541229001055	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
541229001056	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
541229001057	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229001058	active site
541229001059	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
541229001060	putative active site [active]
541229001061	catalytic residue [active]
541229001062	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
541229001063	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
541229001064	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
541229001065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229001066	ATP binding site [chemical binding]; other site
541229001067	putative Mg++ binding site [ion binding]; other site
541229001068	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229001069	nucleotide binding region [chemical binding]; other site
541229001070	ATP-binding site [chemical binding]; other site
541229001071	TRCF domain; Region: TRCF; pfam03461
541229001072	stage V sporulation protein T; Region: spore_V_T; TIGR02851
541229001073	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
541229001074	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
541229001075	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
541229001076	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
541229001077	putative SAM binding site [chemical binding]; other site
541229001078	putative homodimer interface [polypeptide binding]; other site
541229001079	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
541229001080	homodimer interface [polypeptide binding]; other site
541229001081	metal binding site [ion binding]; metal-binding site
541229001082	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
541229001083	homodimer interface [polypeptide binding]; other site
541229001084	active site
541229001085	putative chemical substrate binding site [chemical binding]; other site
541229001086	metal binding site [ion binding]; metal-binding site
541229001087	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229001088	RNA binding surface [nucleotide binding]; other site
541229001089	sporulation protein YabP; Region: spore_yabP; TIGR02892
541229001090	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
541229001091	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
541229001092	Septum formation initiator; Region: DivIC; pfam04977
541229001093	hypothetical protein; Provisional; Region: PRK08582
541229001094	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
541229001095	RNA binding site [nucleotide binding]; other site
541229001096	stage II sporulation protein E; Region: spore_II_E; TIGR02865
541229001097	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
541229001098	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
541229001099	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
541229001100	Ligand Binding Site [chemical binding]; other site
541229001101	TilS substrate binding domain; Region: TilS; pfam09179
541229001102	tRNA(Ile)-lysidine synthetase, C-terminal domain; Region: lysidine_TilS_C; TIGR02433
541229001103	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229001104	active site
541229001105	FtsH Extracellular; Region: FtsH_ext; pfam06480
541229001106	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
541229001107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229001108	Walker A motif; other site
541229001109	ATP binding site [chemical binding]; other site
541229001110	Walker B motif; other site
541229001111	arginine finger; other site
541229001112	Peptidase family M41; Region: Peptidase_M41; pfam01434
541229001113	pantothenate kinase; Reviewed; Region: PRK13318
541229001114	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
541229001115	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
541229001116	dimerization interface [polypeptide binding]; other site
541229001117	domain crossover interface; other site
541229001118	redox-dependent activation switch; other site
541229001119	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
541229001120	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
541229001121	dimer interface [polypeptide binding]; other site
541229001122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229001123	catalytic residue [active]
541229001124	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
541229001125	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
541229001126	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
541229001127	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
541229001128	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
541229001129	glutamine binding [chemical binding]; other site
541229001130	catalytic triad [active]
541229001131	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
541229001132	4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650
541229001133	homodimer interface [polypeptide binding]; other site
541229001134	substrate-cofactor binding pocket; other site
541229001135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229001136	catalytic residue [active]
541229001137	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
541229001138	dihydropteroate synthase; Region: DHPS; TIGR01496
541229001139	substrate binding pocket [chemical binding]; other site
541229001140	dimer interface [polypeptide binding]; other site
541229001141	inhibitor binding site; inhibition site
541229001142	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
541229001143	homooctamer interface [polypeptide binding]; other site
541229001144	active site
541229001145	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
541229001146	catalytic center binding site [active]
541229001147	ATP binding site [chemical binding]; other site
541229001148	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229001149	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229001150	non-specific DNA binding site [nucleotide binding]; other site
541229001151	salt bridge; other site
541229001152	sequence-specific DNA binding site [nucleotide binding]; other site
541229001153	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
541229001154	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
541229001155	FMN binding site [chemical binding]; other site
541229001156	active site
541229001157	catalytic residues [active]
541229001158	substrate binding site [chemical binding]; other site
541229001159	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
541229001160	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
541229001161	dimer interface [polypeptide binding]; other site
541229001162	putative anticodon binding site; other site
541229001163	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
541229001164	motif 1; other site
541229001165	active site
541229001166	motif 2; other site
541229001167	motif 3; other site
541229001168	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229001169	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229001170	DNA-binding site [nucleotide binding]; DNA binding site
541229001171	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229001172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229001173	homodimer interface [polypeptide binding]; other site
541229001174	catalytic residue [active]
541229001175	Proline dehydrogenase; Region: Pro_dh; cl03282
541229001176	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
541229001177	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
541229001178	UvrB/uvrC motif; Region: UVR; pfam02151
541229001179	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
541229001180	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
541229001181	ADP binding site [chemical binding]; other site
541229001182	phosphagen binding site; other site
541229001183	substrate specificity loop; other site
541229001184	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
541229001185	Clp amino terminal domain; Region: Clp_N; pfam02861
541229001186	Clp amino terminal domain; Region: Clp_N; pfam02861
541229001187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229001188	Walker A motif; other site
541229001189	ATP binding site [chemical binding]; other site
541229001190	Walker B motif; other site
541229001191	arginine finger; other site
541229001192	UvrB/uvrC motif; Region: UVR; pfam02151
541229001193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229001194	Walker A motif; other site
541229001195	ATP binding site [chemical binding]; other site
541229001196	Walker B motif; other site
541229001197	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
541229001198	DNA repair protein RadA; Provisional; Region: PRK11823
541229001199	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
541229001200	Walker A motif/ATP binding site; other site
541229001201	ATP binding site [chemical binding]; other site
541229001202	Walker B motif; other site
541229001203	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
541229001204	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
541229001205	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
541229001206	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
541229001207	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
541229001208	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
541229001209	putative active site [active]
541229001210	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
541229001211	substrate binding site; other site
541229001212	dimer interface; other site
541229001213	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
541229001214	homotrimer interaction site [polypeptide binding]; other site
541229001215	zinc binding site [ion binding]; other site
541229001216	CDP-binding sites; other site
541229001217	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
541229001218	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
541229001219	HIGH motif; other site
541229001220	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
541229001221	active site
541229001222	KMSKS motif; other site
541229001223	serine O-acetyltransferase; Region: cysE; TIGR01172
541229001224	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
541229001225	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
541229001226	trimer interface [polypeptide binding]; other site
541229001227	active site
541229001228	substrate binding site [chemical binding]; other site
541229001229	CoA binding site [chemical binding]; other site
541229001230	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
541229001231	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
541229001232	active site
541229001233	HIGH motif; other site
541229001234	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
541229001235	KMSKS motif; other site
541229001236	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
541229001237	tRNA binding surface [nucleotide binding]; other site
541229001238	anticodon binding site; other site
541229001239	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
541229001240	active site
541229001241	metal binding site [ion binding]; metal-binding site
541229001242	dimerization interface [polypeptide binding]; other site
541229001243	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
541229001244	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
541229001245	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
541229001246	YacP-like NYN domain; Region: NYN_YacP; pfam05991
541229001247	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
541229001248	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229001249	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
541229001250	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
541229001251	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
541229001252	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
541229001253	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
541229001254	putative homodimer interface [polypeptide binding]; other site
541229001255	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
541229001256	heterodimer interface [polypeptide binding]; other site
541229001257	homodimer interface [polypeptide binding]; other site
541229001258	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
541229001259	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
541229001260	23S rRNA interface [nucleotide binding]; other site
541229001261	L7/L12 interface [polypeptide binding]; other site
541229001262	putative thiostrepton binding site; other site
541229001263	L25 interface [polypeptide binding]; other site
541229001264	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
541229001265	mRNA/rRNA interface [nucleotide binding]; other site
541229001266	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
541229001267	23S rRNA interface [nucleotide binding]; other site
541229001268	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
541229001269	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
541229001270	core dimer interface [polypeptide binding]; other site
541229001271	peripheral dimer interface [polypeptide binding]; other site
541229001272	L10 interface [polypeptide binding]; other site
541229001273	L11 interface [polypeptide binding]; other site
541229001274	putative EF-Tu interaction site [polypeptide binding]; other site
541229001275	putative EF-G interaction site [polypeptide binding]; other site
541229001276	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
541229001277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001278	S-adenosylmethionine binding site [chemical binding]; other site
541229001279	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
541229001280	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
541229001281	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
541229001282	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
541229001283	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
541229001284	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
541229001285	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
541229001286	RPB10 interaction site [polypeptide binding]; other site
541229001287	RPB1 interaction site [polypeptide binding]; other site
541229001288	RPB11 interaction site [polypeptide binding]; other site
541229001289	RPB3 interaction site [polypeptide binding]; other site
541229001290	RPB12 interaction site [polypeptide binding]; other site
541229001291	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
541229001292	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
541229001293	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
541229001294	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
541229001295	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
541229001296	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
541229001297	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
541229001298	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
541229001299	G-loop; other site
541229001300	DNA binding site [nucleotide binding]
541229001301	hypothetical protein; Provisional; Region: PRK06683
541229001302	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
541229001303	S17 interaction site [polypeptide binding]; other site
541229001304	S8 interaction site; other site
541229001305	16S rRNA interaction site [nucleotide binding]; other site
541229001306	streptomycin interaction site [chemical binding]; other site
541229001307	23S rRNA interaction site [nucleotide binding]; other site
541229001308	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
541229001309	30S ribosomal protein S7; Validated; Region: PRK05302
541229001310	elongation factor G; Reviewed; Region: PRK00007
541229001311	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
541229001312	G1 box; other site
541229001313	putative GEF interaction site [polypeptide binding]; other site
541229001314	GTP/Mg2+ binding site [chemical binding]; other site
541229001315	Switch I region; other site
541229001316	G2 box; other site
541229001317	G3 box; other site
541229001318	Switch II region; other site
541229001319	G4 box; other site
541229001320	G5 box; other site
541229001321	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
541229001322	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
541229001323	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
541229001324	elongation factor Tu; Reviewed; Region: PRK00049
541229001325	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
541229001326	G1 box; other site
541229001327	GEF interaction site [polypeptide binding]; other site
541229001328	GTP/Mg2+ binding site [chemical binding]; other site
541229001329	Switch I region; other site
541229001330	G2 box; other site
541229001331	G3 box; other site
541229001332	Switch II region; other site
541229001333	G4 box; other site
541229001334	G5 box; other site
541229001335	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
541229001336	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
541229001337	Antibiotic Binding Site [chemical binding]; other site
541229001338	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
541229001339	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
541229001340	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
541229001341	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
541229001342	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
541229001343	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
541229001344	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
541229001345	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
541229001346	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
541229001347	putative translocon binding site; other site
541229001348	protein-rRNA interface [nucleotide binding]; other site
541229001349	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
541229001350	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
541229001351	G-X-X-G motif; other site
541229001352	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
541229001353	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
541229001354	23S rRNA interface [nucleotide binding]; other site
541229001355	5S rRNA interface [nucleotide binding]; other site
541229001356	putative antibiotic binding site [chemical binding]; other site
541229001357	L25 interface [polypeptide binding]; other site
541229001358	L27 interface [polypeptide binding]; other site
541229001359	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
541229001360	23S rRNA interface [nucleotide binding]; other site
541229001361	putative translocon interaction site; other site
541229001362	signal recognition particle (SRP54) interaction site; other site
541229001363	L23 interface [polypeptide binding]; other site
541229001364	trigger factor interaction site; other site
541229001365	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
541229001366	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
541229001367	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
541229001368	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
541229001369	RNA binding site [nucleotide binding]; other site
541229001370	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
541229001371	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
541229001372	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
541229001373	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
541229001374	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
541229001375	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
541229001376	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
541229001377	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
541229001378	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
541229001379	5S rRNA interface [nucleotide binding]; other site
541229001380	L27 interface [polypeptide binding]; other site
541229001381	23S rRNA interface [nucleotide binding]; other site
541229001382	L5 interface [polypeptide binding]; other site
541229001383	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
541229001384	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
541229001385	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
541229001386	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
541229001387	23S rRNA binding site [nucleotide binding]; other site
541229001388	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
541229001389	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
541229001390	SecY translocase; Region: SecY; pfam00344
541229001391	adenylate kinase; Reviewed; Region: adk; PRK00279
541229001392	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
541229001393	AMP-binding site [chemical binding]; other site
541229001394	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
541229001395	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
541229001396	active site
541229001397	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
541229001398	rRNA binding site [nucleotide binding]; other site
541229001399	predicted 30S ribosome binding site; other site
541229001400	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
541229001401	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
541229001402	30S ribosomal protein S13; Region: bact_S13; TIGR03631
541229001403	30S ribosomal protein S11; Validated; Region: PRK05309
541229001404	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
541229001405	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
541229001406	alphaNTD - beta interaction site [polypeptide binding]; other site
541229001407	alphaNTD homodimer interface [polypeptide binding]; other site
541229001408	alphaNTD - beta' interaction site [polypeptide binding]; other site
541229001409	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
541229001410	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
541229001411	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
541229001412	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
541229001413	Walker A/P-loop; other site
541229001414	ATP binding site [chemical binding]; other site
541229001415	Q-loop/lid; other site
541229001416	ABC transporter signature motif; other site
541229001417	Walker B; other site
541229001418	D-loop; other site
541229001419	H-loop/switch region; other site
541229001420	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
541229001421	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
541229001422	Walker A/P-loop; other site
541229001423	ATP binding site [chemical binding]; other site
541229001424	Q-loop/lid; other site
541229001425	ABC transporter signature motif; other site
541229001426	Walker B; other site
541229001427	D-loop; other site
541229001428	H-loop/switch region; other site
541229001429	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
541229001430	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
541229001431	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
541229001432	dimerization interface 3.5A [polypeptide binding]; other site
541229001433	active site
541229001434	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
541229001435	23S rRNA interface [nucleotide binding]; other site
541229001436	L3 interface [polypeptide binding]; other site
541229001437	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
541229001438	Protein of unknown function (DUF2521); Region: DUF2521; pfam10730
541229001439	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
541229001440	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
541229001441	active site
541229001442	metal binding site [ion binding]; metal-binding site
541229001443	Domain of unknown function DUF59; Region: DUF59; cl00941
541229001444	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
541229001445	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
541229001446	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
541229001447	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229001448	Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949
541229001449	NodB motif; other site
541229001450	putative active site [active]
541229001451	putative catalytic site [active]
541229001452	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
541229001453	Arginase family; Region: Arginase; cd09989
541229001454	agmatinase; Region: agmatinase; TIGR01230
541229001455	active site
541229001456	Mn binding site [ion binding]; other site
541229001457	oligomer interface [polypeptide binding]; other site
541229001458	Uncharacterized conserved protein [Function unknown]; Region: COG1624
541229001459	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
541229001460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
541229001461	YbbR-like protein; Region: YbbR; pfam07949
541229001462	YbbR-like protein; Region: YbbR; pfam07949
541229001463	YbbR-like protein; Region: YbbR; pfam07949
541229001464	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
541229001465	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
541229001466	active site
541229001467	substrate binding site [chemical binding]; other site
541229001468	metal binding site [ion binding]; metal-binding site
541229001469	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
541229001470	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
541229001471	glutaminase active site [active]
541229001472	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
541229001473	dimer interface [polypeptide binding]; other site
541229001474	active site
541229001475	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
541229001476	dimer interface [polypeptide binding]; other site
541229001477	active site
541229001478	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
541229001479	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229001480	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
541229001481	Predicted membrane protein [Function unknown]; Region: COG2259
541229001482	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859
541229001483	classical (c) SDRs; Region: SDR_c; cd05233
541229001484	NAD(P) binding site [chemical binding]; other site
541229001485	active site
541229001486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001487	ABC-ATPase subunit interface; other site
541229001488	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
541229001489	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
541229001490	Walker A/P-loop; other site
541229001491	ATP binding site [chemical binding]; other site
541229001492	Q-loop/lid; other site
541229001493	ABC transporter signature motif; other site
541229001494	Walker B; other site
541229001495	D-loop; other site
541229001496	H-loop/switch region; other site
541229001497	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
541229001498	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
541229001499	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
541229001500	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
541229001501	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229001502	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
541229001503	putative NAD(P) binding site [chemical binding]; other site
541229001504	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
541229001505	FAD binding domain; Region: FAD_binding_4; pfam01565
541229001506	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229001507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229001508	putative substrate translocation pore; other site
541229001509	Domain of unknown function (DUF3981); Region: DUF3981; pfam13139
541229001510	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
541229001511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229001512	putative substrate translocation pore; other site
541229001513	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
541229001514	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
541229001515	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
541229001516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001517	dimer interface [polypeptide binding]; other site
541229001518	conserved gate region; other site
541229001519	putative PBP binding loops; other site
541229001520	ABC-ATPase subunit interface; other site
541229001521	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229001522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001523	dimer interface [polypeptide binding]; other site
541229001524	conserved gate region; other site
541229001525	putative PBP binding loops; other site
541229001526	ABC-ATPase subunit interface; other site
541229001527	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
541229001528	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229001529	Walker A/P-loop; other site
541229001530	ATP binding site [chemical binding]; other site
541229001531	Q-loop/lid; other site
541229001532	ABC transporter signature motif; other site
541229001533	Walker B; other site
541229001534	D-loop; other site
541229001535	H-loop/switch region; other site
541229001536	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
541229001537	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
541229001538	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229001539	Walker A/P-loop; other site
541229001540	ATP binding site [chemical binding]; other site
541229001541	Q-loop/lid; other site
541229001542	ABC transporter signature motif; other site
541229001543	Walker B; other site
541229001544	D-loop; other site
541229001545	H-loop/switch region; other site
541229001546	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
541229001547	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229001548	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229001549	peptide binding site [polypeptide binding]; other site
541229001550	YusW-like protein; Region: YusW; pfam14039
541229001551	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229001552	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229001553	peptide binding site [polypeptide binding]; other site
541229001554	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229001555	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229001556	peptide binding site [polypeptide binding]; other site
541229001557	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229001558	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229001559	active site
541229001560	catalytic tetrad [active]
541229001561	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634
541229001562	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
541229001563	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
541229001564	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
541229001565	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
541229001566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001567	dimer interface [polypeptide binding]; other site
541229001568	conserved gate region; other site
541229001569	putative PBP binding loops; other site
541229001570	ABC-ATPase subunit interface; other site
541229001571	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
541229001572	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
541229001573	dimerization interface [polypeptide binding]; other site
541229001574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229001575	membrane-bound complex binding site; other site
541229001576	hinge residues; other site
541229001577	DNA binding domain, excisionase family; Region: excise; TIGR01764
541229001578	PBP superfamily domain; Region: PBP_like; pfam12727
541229001579	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229001580	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229001581	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
541229001582	putative dimerization interface [polypeptide binding]; other site
541229001583	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229001584	EamA-like transporter family; Region: EamA; pfam00892
541229001585	YrzO-like protein; Region: YrzO; pfam14142
541229001586	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
541229001587	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
541229001588	putative acyl-acceptor binding pocket; other site
541229001589	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229001590	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229001591	DNA binding site [nucleotide binding]
541229001592	domain linker motif; other site
541229001593	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
541229001594	putative ligand binding site [chemical binding]; other site
541229001595	putative dimerization interface [polypeptide binding]; other site
541229001596	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229001597	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229001598	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229001599	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229001600	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
541229001601	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
541229001602	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
541229001603	active site
541229001604	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
541229001605	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
541229001606	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
541229001607	N-acetyl-D-glucosamine binding site [chemical binding]; other site
541229001608	catalytic residue [active]
541229001609	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
541229001610	nucleotide binding site/active site [active]
541229001611	HIT family signature motif; other site
541229001612	catalytic residue [active]
541229001613	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229001614	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229001615	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229001616	ABC transporter; Region: ABC_tran_2; pfam12848
541229001617	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229001618	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
541229001619	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
541229001620	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
541229001621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001622	dimer interface [polypeptide binding]; other site
541229001623	conserved gate region; other site
541229001624	putative PBP binding loops; other site
541229001625	ABC-ATPase subunit interface; other site
541229001626	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229001627	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
541229001628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001629	dimer interface [polypeptide binding]; other site
541229001630	conserved gate region; other site
541229001631	putative PBP binding loops; other site
541229001632	ABC-ATPase subunit interface; other site
541229001633	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
541229001634	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229001635	Walker A/P-loop; other site
541229001636	ATP binding site [chemical binding]; other site
541229001637	Q-loop/lid; other site
541229001638	ABC transporter signature motif; other site
541229001639	Walker B; other site
541229001640	D-loop; other site
541229001641	H-loop/switch region; other site
541229001642	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
541229001643	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
541229001644	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229001645	Walker A/P-loop; other site
541229001646	ATP binding site [chemical binding]; other site
541229001647	Q-loop/lid; other site
541229001648	ABC transporter signature motif; other site
541229001649	Walker B; other site
541229001650	D-loop; other site
541229001651	H-loop/switch region; other site
541229001652	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
541229001653	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229001654	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229001655	active site
541229001656	motif I; other site
541229001657	motif II; other site
541229001658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229001659	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
541229001660	Protein of unknown function (DUF3948); Region: DUF3948; pfam13134
541229001661	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
541229001662	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
541229001663	dimer interface [polypeptide binding]; other site
541229001664	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
541229001665	active site
541229001666	Fe binding site [ion binding]; other site
541229001667	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
541229001668	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
541229001669	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
541229001670	amino acid transporter; Region: 2A0306; TIGR00909
541229001671	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
541229001672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229001673	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229001674	putative substrate translocation pore; other site
541229001675	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
541229001676	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
541229001677	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
541229001678	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
541229001679	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
541229001680	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
541229001681	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
541229001682	helicase 45; Provisional; Region: PTZ00424
541229001683	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
541229001684	ATP binding site [chemical binding]; other site
541229001685	Mg++ binding site [ion binding]; other site
541229001686	motif III; other site
541229001687	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229001688	nucleotide binding region [chemical binding]; other site
541229001689	ATP-binding site [chemical binding]; other site
541229001690	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
541229001691	Rhomboid family; Region: Rhomboid; pfam01694
541229001692	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
541229001693	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
541229001694	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
541229001695	alanine racemase; Reviewed; Region: alr; PRK00053
541229001696	active site
541229001697	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
541229001698	dimer interface [polypeptide binding]; other site
541229001699	substrate binding site [chemical binding]; other site
541229001700	catalytic residues [active]
541229001701	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
541229001702	PemK-like protein; Region: PemK; pfam02452
541229001703	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
541229001704	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
541229001705	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
541229001706	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
541229001707	RNA binding site [nucleotide binding]; other site
541229001708	hypothetical protein; Provisional; Region: PRK04351
541229001709	SprT homologues; Region: SprT; cl01182
541229001710	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
541229001711	Glycoprotease family; Region: Peptidase_M22; pfam00814
541229001712	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
541229001713	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
541229001714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229001715	Coenzyme A binding pocket [chemical binding]; other site
541229001716	UGMP family protein; Validated; Region: PRK09604
541229001717	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
541229001718	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
541229001719	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229001720	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229001721	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229001722	ABC transporter; Region: ABC_tran_2; pfam12848
541229001723	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229001724	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
541229001725	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
541229001726	CoA binding domain; Region: CoA_binding; pfam02629
541229001727	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
541229001728	CAAX protease self-immunity; Region: Abi; pfam02517
541229001729	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
541229001730	oligomerisation interface [polypeptide binding]; other site
541229001731	mobile loop; other site
541229001732	roof hairpin; other site
541229001733	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
541229001734	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
541229001735	ring oligomerisation interface [polypeptide binding]; other site
541229001736	ATP/Mg binding site [chemical binding]; other site
541229001737	stacking interactions; other site
541229001738	hinge regions; other site
541229001739	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
541229001740	Uncharacterized conserved protein [Function unknown]; Region: COG5444
541229001741	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
541229001742	GMP synthase; Reviewed; Region: guaA; PRK00074
541229001743	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
541229001744	AMP/PPi binding site [chemical binding]; other site
541229001745	candidate oxyanion hole; other site
541229001746	catalytic triad [active]
541229001747	potential glutamine specificity residues [chemical binding]; other site
541229001748	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
541229001749	ATP Binding subdomain [chemical binding]; other site
541229001750	Ligand Binding sites [chemical binding]; other site
541229001751	Dimerization subdomain; other site
541229001752	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
541229001753	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229001754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229001755	active site
541229001756	phosphorylation site [posttranslational modification]
541229001757	intermolecular recognition site; other site
541229001758	dimerization interface [polypeptide binding]; other site
541229001759	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229001760	DNA binding site [nucleotide binding]
541229001761	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229001762	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229001763	dimerization interface [polypeptide binding]; other site
541229001764	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229001765	dimer interface [polypeptide binding]; other site
541229001766	phosphorylation site [posttranslational modification]
541229001767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229001768	ATP binding site [chemical binding]; other site
541229001769	Mg2+ binding site [ion binding]; other site
541229001770	G-X-G motif; other site
541229001771	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229001772	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229001773	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229001774	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
541229001775	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
541229001776	catalytic residues [active]
541229001777	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
541229001778	putative catalytic site [active]
541229001779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229001780	Integrase core domain; Region: rve; pfam00665
541229001781	transposase/IS protein; Provisional; Region: PRK09183
541229001782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229001783	Walker A motif; other site
541229001784	ATP binding site [chemical binding]; other site
541229001785	Walker B motif; other site
541229001786	arginine finger; other site
541229001787	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
541229001788	putative ligand binding site [chemical binding]; other site
541229001789	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229001790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001791	S-adenosylmethionine binding site [chemical binding]; other site
541229001792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001793	S-adenosylmethionine binding site [chemical binding]; other site
541229001794	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
541229001795	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
541229001796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229001797	NAD(P) binding site [chemical binding]; other site
541229001798	active site
541229001799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001800	S-adenosylmethionine binding site [chemical binding]; other site
541229001801	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229001802	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
541229001803	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229001804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229001805	active site
541229001806	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229001807	EamA-like transporter family; Region: EamA; pfam00892
541229001808	EamA-like transporter family; Region: EamA; pfam00892
541229001809	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
541229001810	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
541229001811	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
541229001812	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
541229001813	NAD binding site [chemical binding]; other site
541229001814	ATP-grasp domain; Region: ATP-grasp; pfam02222
541229001815	adenylosuccinate lyase; Provisional; Region: PRK07492
541229001816	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
541229001817	tetramer interface [polypeptide binding]; other site
541229001818	active site
541229001819	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
541229001820	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
541229001821	ATP binding site [chemical binding]; other site
541229001822	active site
541229001823	substrate binding site [chemical binding]; other site
541229001824	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
541229001825	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
541229001826	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
541229001827	putative active site [active]
541229001828	catalytic triad [active]
541229001829	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
541229001830	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
541229001831	dimerization interface [polypeptide binding]; other site
541229001832	ATP binding site [chemical binding]; other site
541229001833	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
541229001834	dimerization interface [polypeptide binding]; other site
541229001835	ATP binding site [chemical binding]; other site
541229001836	amidophosphoribosyltransferase; Provisional; Region: PRK06781
541229001837	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
541229001838	active site
541229001839	tetramer interface [polypeptide binding]; other site
541229001840	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229001841	active site
541229001842	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
541229001843	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
541229001844	dimerization interface [polypeptide binding]; other site
541229001845	putative ATP binding site [chemical binding]; other site
541229001846	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
541229001847	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
541229001848	active site
541229001849	substrate binding site [chemical binding]; other site
541229001850	cosubstrate binding site; other site
541229001851	catalytic site [active]
541229001852	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
541229001853	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
541229001854	purine monophosphate binding site [chemical binding]; other site
541229001855	dimer interface [polypeptide binding]; other site
541229001856	putative catalytic residues [active]
541229001857	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
541229001858	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
541229001859	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
541229001860	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
541229001861	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
541229001862	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
541229001863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229001864	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229001865	putative substrate translocation pore; other site
541229001866	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229001867	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229001868	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
541229001869	putative dimerization interface [polypeptide binding]; other site
541229001870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
541229001871	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
541229001872	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
541229001873	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
541229001874	PcrB family; Region: PcrB; pfam01884
541229001875	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
541229001876	substrate binding site [chemical binding]; other site
541229001877	putative active site [active]
541229001878	dimer interface [polypeptide binding]; other site
541229001879	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
541229001880	Part of AAA domain; Region: AAA_19; pfam13245
541229001881	Family description; Region: UvrD_C_2; pfam13538
541229001882	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
541229001883	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
541229001884	nucleotide binding pocket [chemical binding]; other site
541229001885	K-X-D-G motif; other site
541229001886	catalytic site [active]
541229001887	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
541229001888	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
541229001889	Dimer interface [polypeptide binding]; other site
541229001890	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
541229001891	putative dimer interface [polypeptide binding]; other site
541229001892	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
541229001893	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
541229001894	putative dimer interface [polypeptide binding]; other site
541229001895	hypothetical protein; Provisional; Region: PRK10621
541229001896	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229001897	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
541229001898	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
541229001899	Glutamate binding site [chemical binding]; other site
541229001900	homodimer interface [polypeptide binding]; other site
541229001901	NAD binding site [chemical binding]; other site
541229001902	catalytic residues [active]
541229001903	Isochorismatase family; Region: Isochorismatase; pfam00857
541229001904	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
541229001905	catalytic triad [active]
541229001906	conserved cis-peptide bond; other site
541229001907	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
541229001908	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
541229001909	Walker A/P-loop; other site
541229001910	ATP binding site [chemical binding]; other site
541229001911	Q-loop/lid; other site
541229001912	ABC transporter signature motif; other site
541229001913	Walker B; other site
541229001914	D-loop; other site
541229001915	H-loop/switch region; other site
541229001916	NIL domain; Region: NIL; pfam09383
541229001917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229001918	dimer interface [polypeptide binding]; other site
541229001919	conserved gate region; other site
541229001920	ABC-ATPase subunit interface; other site
541229001921	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
541229001922	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
541229001923	Protein of unknown function (DUF3926); Region: DUF3926; pfam13080
541229001924	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
541229001925	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
541229001926	P loop; other site
541229001927	Nucleotide binding site [chemical binding]; other site
541229001928	DTAP/Switch II; other site
541229001929	Switch I; other site
541229001930	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
541229001931	putative dimer interface [polypeptide binding]; other site
541229001932	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229001933	MarR family; Region: MarR; pfam01047
541229001934	MarR family; Region: MarR_2; cl17246
541229001935	yiaA/B two helix domain; Region: YiaAB; pfam05360
541229001936	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
541229001937	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
541229001938	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
541229001939	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
541229001940	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
541229001941	GatB domain; Region: GatB_Yqey; pfam02637
541229001942	putative lipid kinase; Reviewed; Region: PRK13337
541229001943	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
541229001944	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
541229001945	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229001946	motif II; other site
541229001947	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
541229001948	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229001949	inhibitor-cofactor binding pocket; inhibition site
541229001950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229001951	catalytic residue [active]
541229001952	PAS domain; Region: PAS_9; pfam13426
541229001953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229001954	putative active site [active]
541229001955	heme pocket [chemical binding]; other site
541229001956	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
541229001957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229001958	Walker A motif; other site
541229001959	ATP binding site [chemical binding]; other site
541229001960	Walker B motif; other site
541229001961	arginine finger; other site
541229001962	succinic semialdehyde dehydrogenase; Region: PLN02278
541229001963	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
541229001964	tetramerization interface [polypeptide binding]; other site
541229001965	NAD(P) binding site [chemical binding]; other site
541229001966	catalytic residues [active]
541229001967	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229001968	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
541229001969	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
541229001970	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
541229001971	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229001972	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
541229001973	putative active site [active]
541229001974	putative metal binding site [ion binding]; other site
541229001975	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229001976	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229001977	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229001978	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
541229001979	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
541229001980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229001981	S-adenosylmethionine binding site [chemical binding]; other site
541229001982	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
541229001983	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
541229001984	FMN binding site [chemical binding]; other site
541229001985	active site
541229001986	catalytic residues [active]
541229001987	substrate binding site [chemical binding]; other site
541229001988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
541229001989	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
541229001990	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
541229001991	Protein of unknown function DUF45; Region: DUF45; pfam01863
541229001992	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
541229001993	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
541229001994	active site
541229001995	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
541229001996	M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018
541229001997	amidohydrolase; Region: amidohydrolases; TIGR01891
541229001998	metal binding site [ion binding]; metal-binding site
541229001999	putative dimer interface [polypeptide binding]; other site
541229002000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229002001	S-adenosylmethionine binding site [chemical binding]; other site
541229002002	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
541229002003	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
541229002004	catalytic residue [active]
541229002005	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
541229002006	catalytic residues [active]
541229002007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229002008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229002009	peroxiredoxin; Region: AhpC; TIGR03137
541229002010	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
541229002011	dimer interface [polypeptide binding]; other site
541229002012	decamer (pentamer of dimers) interface [polypeptide binding]; other site
541229002013	catalytic triad [active]
541229002014	peroxidatic and resolving cysteines [active]
541229002015	5-methylribose kinase; Reviewed; Region: PRK12396
541229002016	Phosphotransferase enzyme family; Region: APH; pfam01636
541229002017	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
541229002018	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
541229002019	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
541229002020	intersubunit interface [polypeptide binding]; other site
541229002021	active site
541229002022	Zn2+ binding site [ion binding]; other site
541229002023	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229002024	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229002025	ABC-ATPase subunit  interface; other site
541229002026	dimer interface [polypeptide binding]; other site
541229002027	putative PBP binding regions; other site
541229002028	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229002029	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229002030	ABC-ATPase subunit  interface; other site
541229002031	dimer interface [polypeptide binding]; other site
541229002032	putative PBP binding regions; other site
541229002033	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
541229002034	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
541229002035	putative ligand binding residues [chemical binding]; other site
541229002036	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
541229002037	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229002038	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
541229002039	DNA binding domain, excisionase family; Region: excise; TIGR01764
541229002040	Sm and related proteins; Region: Sm_like; cl00259
541229002041	Sm1 motif; other site
541229002042	RNA binding site [nucleotide binding]; other site
541229002043	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
541229002044	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229002045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229002046	dimer interface [polypeptide binding]; other site
541229002047	phosphorylation site [posttranslational modification]
541229002048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229002049	ATP binding site [chemical binding]; other site
541229002050	Mg2+ binding site [ion binding]; other site
541229002051	G-X-G motif; other site
541229002052	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
541229002053	hypothetical protein; Provisional; Region: PRK06851
541229002054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229002055	Walker A motif; other site
541229002056	ATP binding site [chemical binding]; other site
541229002057	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
541229002058	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
541229002059	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
541229002060	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
541229002061	[2Fe-2S] cluster binding site [ion binding]; other site
541229002062	Fatty acid desaturase; Region: FA_desaturase; pfam00487
541229002063	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
541229002064	putative di-iron ligands [ion binding]; other site
541229002065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
541229002066	putative PBP binding loops; other site
541229002067	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229002068	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
541229002069	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229002070	substrate binding pocket [chemical binding]; other site
541229002071	membrane-bound complex binding site; other site
541229002072	hinge residues; other site
541229002073	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
541229002074	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
541229002075	Walker A/P-loop; other site
541229002076	ATP binding site [chemical binding]; other site
541229002077	Q-loop/lid; other site
541229002078	ABC transporter signature motif; other site
541229002079	Walker B; other site
541229002080	D-loop; other site
541229002081	H-loop/switch region; other site
541229002082	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
541229002083	HAMP domain; Region: HAMP; pfam00672
541229002084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229002085	dimer interface [polypeptide binding]; other site
541229002086	putative CheW interface [polypeptide binding]; other site
541229002087	Arginine repressor [Transcription]; Region: ArgR; COG1438
541229002088	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
541229002089	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
541229002090	arginine deiminase; Provisional; Region: PRK01388
541229002091	ornithine carbamoyltransferase; Validated; Region: PRK02102
541229002092	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
541229002093	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
541229002094	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
541229002095	carbamate kinase; Reviewed; Region: PRK12686
541229002096	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
541229002097	putative substrate binding site [chemical binding]; other site
541229002098	nucleotide binding site [chemical binding]; other site
541229002099	nucleotide binding site [chemical binding]; other site
541229002100	homodimer interface [polypeptide binding]; other site
541229002101	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
541229002102	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
541229002103	ligand binding site [chemical binding]; other site
541229002104	flexible hinge region; other site
541229002105	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
541229002106	putative switch regulator; other site
541229002107	non-specific DNA interactions [nucleotide binding]; other site
541229002108	DNA binding site [nucleotide binding]
541229002109	sequence specific DNA binding site [nucleotide binding]; other site
541229002110	putative cAMP binding site [chemical binding]; other site
541229002111	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
541229002112	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
541229002113	FAD binding domain; Region: FAD_binding_4; pfam01565
541229002114	Berberine and berberine like; Region: BBE; pfam08031
541229002115	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
541229002116	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
541229002117	Ca binding site [ion binding]; other site
541229002118	active site
541229002119	catalytic site [active]
541229002120	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229002121	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
541229002122	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
541229002123	active site turn [active]
541229002124	phosphorylation site [posttranslational modification]
541229002125	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
541229002126	putative catalytic site [active]
541229002127	putative metal binding site [ion binding]; other site
541229002128	putative phosphate binding site [ion binding]; other site
541229002129	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
541229002130	Predicted membrane protein [Function unknown]; Region: COG1511
541229002131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002132	DNA topoisomerase III; Provisional; Region: PRK07726
541229002133	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
541229002134	active site
541229002135	putative interdomain interaction site [polypeptide binding]; other site
541229002136	putative metal-binding site [ion binding]; other site
541229002137	putative nucleotide binding site [chemical binding]; other site
541229002138	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
541229002139	domain I; other site
541229002140	DNA binding groove [nucleotide binding]
541229002141	phosphate binding site [ion binding]; other site
541229002142	domain II; other site
541229002143	domain III; other site
541229002144	nucleotide binding site [chemical binding]; other site
541229002145	catalytic site [active]
541229002146	domain IV; other site
541229002147	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
541229002148	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
541229002149	substrate binding site [chemical binding]; other site
541229002150	multimerization interface [polypeptide binding]; other site
541229002151	ATP binding site [chemical binding]; other site
541229002152	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
541229002153	thiamine phosphate binding site [chemical binding]; other site
541229002154	active site
541229002155	pyrophosphate binding site [ion binding]; other site
541229002156	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
541229002157	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
541229002158	HAMP domain; Region: HAMP; pfam00672
541229002159	dimerization interface [polypeptide binding]; other site
541229002160	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229002161	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229002162	dimer interface [polypeptide binding]; other site
541229002163	putative CheW interface [polypeptide binding]; other site
541229002164	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229002165	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
541229002166	acyl-activating enzyme (AAE) consensus motif; other site
541229002167	AMP binding site [chemical binding]; other site
541229002168	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229002169	thioester reductase domain; Region: Thioester-redct; TIGR01746
541229002170	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
541229002171	putative NAD(P) binding site [chemical binding]; other site
541229002172	active site
541229002173	putative substrate binding site [chemical binding]; other site
541229002174	Domain of unknown function DUF77; Region: DUF77; pfam01910
541229002175	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
541229002176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002177	dimer interface [polypeptide binding]; other site
541229002178	conserved gate region; other site
541229002179	putative PBP binding loops; other site
541229002180	ABC-ATPase subunit interface; other site
541229002181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
541229002182	NMT1/THI5 like; Region: NMT1; pfam09084
541229002183	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
541229002184	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
541229002185	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
541229002186	Walker A/P-loop; other site
541229002187	ATP binding site [chemical binding]; other site
541229002188	Q-loop/lid; other site
541229002189	ABC transporter signature motif; other site
541229002190	Walker B; other site
541229002191	D-loop; other site
541229002192	H-loop/switch region; other site
541229002193	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229002194	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229002195	Walker A/P-loop; other site
541229002196	ATP binding site [chemical binding]; other site
541229002197	Q-loop/lid; other site
541229002198	ABC transporter signature motif; other site
541229002199	Walker B; other site
541229002200	D-loop; other site
541229002201	H-loop/switch region; other site
541229002202	ABC transporter; Region: ABC_tran_2; pfam12848
541229002203	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229002204	Glyco_18 domain; Region: Glyco_18; smart00636
541229002205	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
541229002206	active site
541229002207	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229002208	Interdomain contacts; other site
541229002209	Cytokine receptor motif; other site
541229002210	Cellulose binding domain; Region: CBM_2; pfam00553
541229002211	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
541229002212	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229002213	catalytic residues [active]
541229002214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229002215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229002216	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
541229002217	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229002218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002219	putative substrate translocation pore; other site
541229002220	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229002221	non-specific DNA binding site [nucleotide binding]; other site
541229002222	salt bridge; other site
541229002223	sequence-specific DNA binding site [nucleotide binding]; other site
541229002224	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
541229002225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002226	putative substrate translocation pore; other site
541229002227	Uncharacterized conserved protein [Function unknown]; Region: COG3379
541229002228	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
541229002229	YesK-like protein; Region: YesK; pfam14150
541229002230	prolyl-tRNA synthetase; Provisional; Region: PRK08661
541229002231	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
541229002232	dimer interface [polypeptide binding]; other site
541229002233	motif 1; other site
541229002234	active site
541229002235	motif 2; other site
541229002236	motif 3; other site
541229002237	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
541229002238	anticodon binding site; other site
541229002239	zinc-binding site [ion binding]; other site
541229002240	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
541229002241	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
541229002242	nucleotide binding site [chemical binding]; other site
541229002243	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
541229002244	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
541229002245	putative metal binding site [ion binding]; other site
541229002246	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
541229002247	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
541229002248	putative metal binding site [ion binding]; other site
541229002249	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
541229002250	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
541229002251	putative metal binding site [ion binding]; other site
541229002252	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
541229002253	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
541229002254	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
541229002255	sarco/endoplasmic reticulum calcium-translocating P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116
541229002256	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229002257	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
541229002258	Soluble P-type ATPase [General function prediction only]; Region: COG4087
541229002259	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
541229002260	Protein of unknown function (DUF1128); Region: DUF1128; pfam06569
541229002261	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
541229002262	Low molecular weight phosphatase family; Region: LMWPc; cd00115
541229002263	active site
541229002264	Domain of unknown function (DUF4075); Region: DUF4075; pfam13294
541229002265	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
541229002266	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
541229002267	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229002268	Soluble P-type ATPase [General function prediction only]; Region: COG4087
541229002269	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229002270	EamA-like transporter family; Region: EamA; pfam00892
541229002271	EamA-like transporter family; Region: EamA; pfam00892
541229002272	YhhN-like protein; Region: YhhN; pfam07947
541229002273	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
541229002274	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229002275	Catalytic site [active]
541229002276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229002277	binding surface
541229002278	TPR motif; other site
541229002279	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229002280	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229002281	Predicted membrane protein [Function unknown]; Region: COG2510
541229002282	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
541229002283	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
541229002284	calcium/proton exchanger (cax); Region: cax; TIGR00378
541229002285	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
541229002286	YfkD-like protein; Region: YfkD; pfam14167
541229002287	Radical SAM superfamily; Region: Radical_SAM; pfam04055
541229002288	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229002289	FeS/SAM binding site; other site
541229002290	YfkB-like domain; Region: YfkB; pfam08756
541229002291	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
541229002292	Fumarase C-terminus; Region: Fumerase_C; pfam05683
541229002293	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
541229002294	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
541229002295	NodB motif; other site
541229002296	active site
541229002297	catalytic site [active]
541229002298	Cd binding site [ion binding]; other site
541229002299	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
541229002300	endonuclease III; Region: ENDO3c; smart00478
541229002301	minor groove reading motif; other site
541229002302	helix-hairpin-helix signature motif; other site
541229002303	substrate binding pocket [chemical binding]; other site
541229002304	active site
541229002305	TRAM domain; Region: TRAM; pfam01938
541229002306	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
541229002307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229002308	S-adenosylmethionine binding site [chemical binding]; other site
541229002309	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
541229002310	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
541229002311	dimerization interface 3.5A [polypeptide binding]; other site
541229002312	active site
541229002313	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
541229002314	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229002315	Walker A motif; other site
541229002316	ATP binding site [chemical binding]; other site
541229002317	Walker B motif; other site
541229002318	arginine finger; other site
541229002319	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
541229002320	hypothetical protein; Validated; Region: PRK06748
541229002321	S-methylmethionine transporter; Provisional; Region: PRK11387
541229002322	acetylornithine deacetylase; Validated; Region: PRK08596
541229002323	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
541229002324	metal binding site [ion binding]; metal-binding site
541229002325	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229002326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229002327	non-specific DNA binding site [nucleotide binding]; other site
541229002328	salt bridge; other site
541229002329	sequence-specific DNA binding site [nucleotide binding]; other site
541229002330	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
541229002331	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
541229002332	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
541229002333	glutaminase A; Region: Gln_ase; TIGR03814
541229002334	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
541229002335	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
541229002336	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229002337	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229002338	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
541229002339	active site turn [active]
541229002340	phosphorylation site [posttranslational modification]
541229002341	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229002342	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229002343	Sm and related proteins; Region: Sm_like; cl00259
541229002344	heptamer interface [polypeptide binding]; other site
541229002345	Sm1 motif; other site
541229002346	hexamer interface [polypeptide binding]; other site
541229002347	RNA binding site [nucleotide binding]; other site
541229002348	Sm2 motif; other site
541229002349	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
541229002350	active site
541229002351	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229002352	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
541229002353	active site
541229002354	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
541229002355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229002356	NAD(P) binding site [chemical binding]; other site
541229002357	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
541229002358	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
541229002359	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
541229002360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229002361	NAD(P) binding site [chemical binding]; other site
541229002362	active site
541229002363	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229002364	active site
541229002365	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229002366	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229002367	active site
541229002368	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
541229002369	Pyruvate formate lyase 1; Region: PFL1; cd01678
541229002370	coenzyme A binding site [chemical binding]; other site
541229002371	active site
541229002372	catalytic residues [active]
541229002373	glycine loop; other site
541229002374	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
541229002375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229002376	FeS/SAM binding site; other site
541229002377	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
541229002378	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
541229002379	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
541229002380	YfhE-like protein; Region: YfhE; pfam14152
541229002381	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229002382	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
541229002383	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
541229002384	active site
541229002385	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
541229002386	TIGR01777 family protein; Region: yfcH
541229002387	putative NAD(P) binding site [chemical binding]; other site
541229002388	putative active site [active]
541229002389	recombination regulator RecX; Provisional; Region: recX; PRK14135
541229002390	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
541229002391	Small acid-soluble spore protein K family; Region: SspK; pfam08176
541229002392	WVELL protein; Region: WVELL; pfam14043
541229002393	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
541229002394	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
541229002395	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
541229002396	minor groove reading motif; other site
541229002397	helix-hairpin-helix signature motif; other site
541229002398	substrate binding pocket [chemical binding]; other site
541229002399	active site
541229002400	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
541229002401	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
541229002402	DNA binding and oxoG recognition site [nucleotide binding]
541229002403	YgaB-like protein; Region: YgaB; pfam14182
541229002404	hypothetical protein; Provisional; Region: PRK13662
541229002405	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229002406	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229002407	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
541229002408	Walker A/P-loop; other site
541229002409	ATP binding site [chemical binding]; other site
541229002410	Q-loop/lid; other site
541229002411	ABC transporter signature motif; other site
541229002412	Walker B; other site
541229002413	D-loop; other site
541229002414	H-loop/switch region; other site
541229002415	Predicted membrane protein [Function unknown]; Region: COG4129
541229002416	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
541229002417	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
541229002418	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
541229002419	active site
541229002420	dimer interface [polypeptide binding]; other site
541229002421	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
541229002422	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
541229002423	active site
541229002424	FMN binding site [chemical binding]; other site
541229002425	substrate binding site [chemical binding]; other site
541229002426	3Fe-4S cluster binding site [ion binding]; other site
541229002427	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
541229002428	domain_subunit interface; other site
541229002429	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
541229002430	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229002431	inhibitor-cofactor binding pocket; inhibition site
541229002432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229002433	catalytic residue [active]
541229002434	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
541229002435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229002436	Walker A/P-loop; other site
541229002437	ATP binding site [chemical binding]; other site
541229002438	Q-loop/lid; other site
541229002439	ABC transporter signature motif; other site
541229002440	Walker B; other site
541229002441	D-loop; other site
541229002442	H-loop/switch region; other site
541229002443	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
541229002444	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
541229002445	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
541229002446	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
541229002447	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
541229002448	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
541229002449	catalytic triad [active]
541229002450	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
541229002451	metal binding site 2 [ion binding]; metal-binding site
541229002452	putative DNA binding helix; other site
541229002453	metal binding site 1 [ion binding]; metal-binding site
541229002454	dimer interface [polypeptide binding]; other site
541229002455	structural Zn2+ binding site [ion binding]; other site
541229002456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229002457	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229002458	Coenzyme A binding pocket [chemical binding]; other site
541229002459	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
541229002460	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
541229002461	hypothetical protein; Provisional; Region: PRK12378
541229002462	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229002463	nudix motif; other site
541229002464	Transglycosylase; Region: Transgly; pfam00912
541229002465	Thioredoxin; Region: Thioredoxin_4; pfam13462
541229002466	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
541229002467	epoxyqueuosine reductase; Region: TIGR00276
541229002468	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
541229002469	4Fe-4S binding domain; Region: Fer4; cl02805
541229002470	Putative amidase domain; Region: Amidase_6; pfam12671
541229002471	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
541229002472	PAS fold; Region: PAS_4; pfam08448
541229002473	PAS domain; Region: PAS_9; pfam13426
541229002474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229002475	putative active site [active]
541229002476	heme pocket [chemical binding]; other site
541229002477	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229002478	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229002479	metal binding site [ion binding]; metal-binding site
541229002480	active site
541229002481	I-site; other site
541229002482	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229002483	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
541229002484	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
541229002485	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
541229002486	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229002487	heme-binding site [chemical binding]; other site
541229002488	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002489	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
541229002490	Leucine-rich repeats; other site
541229002491	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002492	Substrate binding site [chemical binding]; other site
541229002493	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002494	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002495	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002496	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002497	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002498	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229002499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229002500	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229002501	Coenzyme A binding pocket [chemical binding]; other site
541229002502	BCCT family transporter; Region: BCCT; pfam02028
541229002503	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
541229002504	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
541229002505	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
541229002506	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
541229002507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
541229002508	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
541229002509	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
541229002510	Cache domain; Region: Cache_1; pfam02743
541229002511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229002512	dimerization interface [polypeptide binding]; other site
541229002513	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229002514	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229002515	dimer interface [polypeptide binding]; other site
541229002516	putative CheW interface [polypeptide binding]; other site
541229002517	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
541229002518	PAS domain; Region: PAS; smart00091
541229002519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229002520	ATP binding site [chemical binding]; other site
541229002521	Mg2+ binding site [ion binding]; other site
541229002522	G-X-G motif; other site
541229002523	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
541229002524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229002525	active site
541229002526	phosphorylation site [posttranslational modification]
541229002527	intermolecular recognition site; other site
541229002528	dimerization interface [polypeptide binding]; other site
541229002529	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
541229002530	Citrate transporter; Region: CitMHS; pfam03600
541229002531	hypothetical protein; Provisional; Region: PRK12784
541229002532	NosL; Region: NosL; cl01769
541229002533	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
541229002534	Ankyrin repeat; Region: Ank; pfam00023
541229002535	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
541229002536	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
541229002537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229002538	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
541229002539	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
541229002540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229002541	Walker A/P-loop; other site
541229002542	ATP binding site [chemical binding]; other site
541229002543	Q-loop/lid; other site
541229002544	ABC transporter signature motif; other site
541229002545	Walker B; other site
541229002546	D-loop; other site
541229002547	H-loop/switch region; other site
541229002548	TOBE domain; Region: TOBE_2; pfam08402
541229002549	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
541229002550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002551	dimer interface [polypeptide binding]; other site
541229002552	conserved gate region; other site
541229002553	putative PBP binding loops; other site
541229002554	ABC-ATPase subunit interface; other site
541229002555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
541229002556	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
541229002557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002558	dimer interface [polypeptide binding]; other site
541229002559	conserved gate region; other site
541229002560	putative PBP binding loops; other site
541229002561	ABC-ATPase subunit interface; other site
541229002562	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
541229002563	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
541229002564	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229002565	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
541229002566	active site
541229002567	metal binding site [ion binding]; metal-binding site
541229002568	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229002569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229002570	active site
541229002571	phosphorylation site [posttranslational modification]
541229002572	intermolecular recognition site; other site
541229002573	dimerization interface [polypeptide binding]; other site
541229002574	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229002575	DNA binding site [nucleotide binding]
541229002576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229002577	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229002578	dimer interface [polypeptide binding]; other site
541229002579	phosphorylation site [posttranslational modification]
541229002580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229002581	ATP binding site [chemical binding]; other site
541229002582	Mg2+ binding site [ion binding]; other site
541229002583	G-X-G motif; other site
541229002584	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
541229002585	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
541229002586	putative active site [active]
541229002587	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
541229002588	Cache domain; Region: Cache_1; pfam02743
541229002589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229002590	dimerization interface [polypeptide binding]; other site
541229002591	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229002592	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229002593	dimer interface [polypeptide binding]; other site
541229002594	putative CheW interface [polypeptide binding]; other site
541229002595	sensory histidine kinase DcuS; Provisional; Region: PRK11086
541229002596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229002597	ATP binding site [chemical binding]; other site
541229002598	Mg2+ binding site [ion binding]; other site
541229002599	G-X-G motif; other site
541229002600	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
541229002601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229002602	active site
541229002603	phosphorylation site [posttranslational modification]
541229002604	intermolecular recognition site; other site
541229002605	dimerization interface [polypeptide binding]; other site
541229002606	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
541229002607	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
541229002608	Malic enzyme, N-terminal domain; Region: malic; pfam00390
541229002609	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
541229002610	putative NAD(P) binding site [chemical binding]; other site
541229002611	EamA-like transporter family; Region: EamA; pfam00892
541229002612	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229002613	EamA-like transporter family; Region: EamA; pfam00892
541229002614	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229002615	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229002616	DNA-binding site [nucleotide binding]; DNA binding site
541229002617	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229002618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229002619	homodimer interface [polypeptide binding]; other site
541229002620	catalytic residue [active]
541229002621	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
541229002622	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229002623	Coenzyme A binding pocket [chemical binding]; other site
541229002624	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229002625	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229002626	dimerization interface [polypeptide binding]; other site
541229002627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229002628	dimer interface [polypeptide binding]; other site
541229002629	phosphorylation site [posttranslational modification]
541229002630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229002631	ATP binding site [chemical binding]; other site
541229002632	Mg2+ binding site [ion binding]; other site
541229002633	G-X-G motif; other site
541229002634	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229002635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229002636	active site
541229002637	phosphorylation site [posttranslational modification]
541229002638	intermolecular recognition site; other site
541229002639	dimerization interface [polypeptide binding]; other site
541229002640	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229002641	DNA binding site [nucleotide binding]
541229002642	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
541229002643	Arrestin_N terminal like; Region: LDB19; pfam13002
541229002644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229002645	Coenzyme A binding pocket [chemical binding]; other site
541229002646	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
541229002647	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
541229002648	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
541229002649	catalytic loop [active]
541229002650	iron binding site [ion binding]; other site
541229002651	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
541229002652	4Fe-4S binding domain; Region: Fer4; pfam00037
541229002653	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
541229002654	[4Fe-4S] binding site [ion binding]; other site
541229002655	molybdopterin cofactor binding site; other site
541229002656	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
541229002657	molybdopterin cofactor binding site; other site
541229002658	Uncharacterized conserved protein [Function unknown]; Region: COG2427
541229002659	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
541229002660	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
541229002661	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
541229002662	putative active site [active]
541229002663	catalytic site [active]
541229002664	putative metal binding site [ion binding]; other site
541229002665	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
541229002666	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
541229002667	hexamer interface [polypeptide binding]; other site
541229002668	ligand binding site [chemical binding]; other site
541229002669	putative active site [active]
541229002670	NAD(P) binding site [chemical binding]; other site
541229002671	amino acid transporter; Region: 2A0306; TIGR00909
541229002672	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
541229002673	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229002674	dimerization interface [polypeptide binding]; other site
541229002675	putative DNA binding site [nucleotide binding]; other site
541229002676	putative Zn2+ binding site [ion binding]; other site
541229002677	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
541229002678	metal-binding site [ion binding]
541229002679	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
541229002680	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
541229002681	metal-binding site [ion binding]
541229002682	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229002683	Soluble P-type ATPase [General function prediction only]; Region: COG4087
541229002684	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
541229002685	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
541229002686	active site
541229002687	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229002688	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229002689	non-specific DNA binding site [nucleotide binding]; other site
541229002690	salt bridge; other site
541229002691	sequence-specific DNA binding site [nucleotide binding]; other site
541229002692	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229002693	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229002694	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229002695	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
541229002696	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
541229002697	active site
541229002698	Zn binding site [ion binding]; other site
541229002699	Uncharacterized conserved protein [Function unknown]; Region: COG0398
541229002700	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229002701	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
541229002702	VanW like protein; Region: VanW; pfam04294
541229002703	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
541229002704	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229002705	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229002706	Nucleoside recognition; Region: Gate; pfam07670
541229002707	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229002708	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229002709	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
541229002710	putative metal binding site [ion binding]; other site
541229002711	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
541229002712	Domain of unknown function DUF21; Region: DUF21; pfam01595
541229002713	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
541229002714	Transporter associated domain; Region: CorC_HlyC; smart01091
541229002715	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
541229002716	Aspartase; Region: Aspartase; cd01357
541229002717	active sites [active]
541229002718	tetramer interface [polypeptide binding]; other site
541229002719	L-lactate permease; Region: Lactate_perm; cl00701
541229002720	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
541229002721	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229002722	dimerization interface [polypeptide binding]; other site
541229002723	putative Zn2+ binding site [ion binding]; other site
541229002724	putative DNA binding site [nucleotide binding]; other site
541229002725	acid-soluble spore protein H; Provisional; Region: sspH; PRK01625
541229002726	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
541229002727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002728	putative substrate translocation pore; other site
541229002729	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
541229002730	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
541229002731	siderophore binding site; other site
541229002732	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229002733	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229002734	ABC-ATPase subunit  interface; other site
541229002735	dimer interface [polypeptide binding]; other site
541229002736	putative PBP binding regions; other site
541229002737	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
541229002738	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229002739	ABC-ATPase subunit  interface; other site
541229002740	dimer interface [polypeptide binding]; other site
541229002741	putative PBP binding regions; other site
541229002742	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
541229002743	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
541229002744	Walker A/P-loop; other site
541229002745	ATP binding site [chemical binding]; other site
541229002746	Q-loop/lid; other site
541229002747	ABC transporter signature motif; other site
541229002748	Walker B; other site
541229002749	D-loop; other site
541229002750	H-loop/switch region; other site
541229002751	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229002752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229002753	S-adenosylmethionine binding site [chemical binding]; other site
541229002754	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
541229002755	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
541229002756	substrate-cofactor binding pocket; other site
541229002757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229002758	catalytic residue [active]
541229002759	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
541229002760	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
541229002761	NAD binding site [chemical binding]; other site
541229002762	homodimer interface [polypeptide binding]; other site
541229002763	active site
541229002764	putative substrate binding site [chemical binding]; other site
541229002765	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229002766	nudix motif; other site
541229002767	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
541229002768	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
541229002769	metal ion-dependent adhesion site (MIDAS); other site
541229002770	MoxR-like ATPases [General function prediction only]; Region: COG0714
541229002771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229002772	Walker A motif; other site
541229002773	ATP binding site [chemical binding]; other site
541229002774	Walker B motif; other site
541229002775	arginine finger; other site
541229002776	cardiolipin synthetase; Reviewed; Region: PRK12452
541229002777	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
541229002778	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
541229002779	putative active site [active]
541229002780	catalytic site [active]
541229002781	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
541229002782	putative active site [active]
541229002783	catalytic site [active]
541229002784	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229002785	PAS domain; Region: PAS_9; pfam13426
541229002786	putative active site [active]
541229002787	heme pocket [chemical binding]; other site
541229002788	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229002789	metal binding site [ion binding]; metal-binding site
541229002790	active site
541229002791	I-site; other site
541229002792	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229002793	Amino acid permease; Region: AA_permease_2; pfam13520
541229002794	Spore germination protein; Region: Spore_permease; cl17796
541229002795	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229002796	DNA-binding site [nucleotide binding]; DNA binding site
541229002797	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
541229002798	UTRA domain; Region: UTRA; pfam07702
541229002799	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
541229002800	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
541229002801	active site turn [active]
541229002802	phosphorylation site [posttranslational modification]
541229002803	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229002804	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
541229002805	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
541229002806	Ca binding site [ion binding]; other site
541229002807	active site
541229002808	catalytic site [active]
541229002809	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
541229002810	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
541229002811	Spore germination protein; Region: Spore_permease; cl17796
541229002812	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229002813	CAAX protease self-immunity; Region: Abi; pfam02517
541229002814	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229002815	active site
541229002816	ATP binding site [chemical binding]; other site
541229002817	substrate binding site [chemical binding]; other site
541229002818	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229002819	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
541229002820	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
541229002821	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
541229002822	Walker A/P-loop; other site
541229002823	ATP binding site [chemical binding]; other site
541229002824	Q-loop/lid; other site
541229002825	ABC transporter signature motif; other site
541229002826	Walker B; other site
541229002827	D-loop; other site
541229002828	H-loop/switch region; other site
541229002829	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
541229002830	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229002831	substrate binding pocket [chemical binding]; other site
541229002832	membrane-bound complex binding site; other site
541229002833	hinge residues; other site
541229002834	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
541229002835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002836	dimer interface [polypeptide binding]; other site
541229002837	conserved gate region; other site
541229002838	putative PBP binding loops; other site
541229002839	ABC-ATPase subunit interface; other site
541229002840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002841	dimer interface [polypeptide binding]; other site
541229002842	conserved gate region; other site
541229002843	putative PBP binding loops; other site
541229002844	ABC-ATPase subunit interface; other site
541229002845	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229002846	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229002847	putative active site [active]
541229002848	putative NTP binding site [chemical binding]; other site
541229002849	putative nucleic acid binding site [nucleotide binding]; other site
541229002850	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229002851	active site
541229002852	S-methylmethionine transporter; Provisional; Region: PRK11387
541229002853	OsmC-like protein; Region: OsmC; pfam02566
541229002854	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
541229002855	nucleotide binding site/active site [active]
541229002856	HIT family signature motif; other site
541229002857	catalytic residue [active]
541229002858	RNA polymerase sigma factor; Provisional; Region: PRK12542
541229002859	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229002860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229002861	DNA binding residues [nucleotide binding]
541229002862	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
541229002863	Predicted transcriptional regulator [Transcription]; Region: COG2378
541229002864	HTH domain; Region: HTH_11; pfam08279
541229002865	WYL domain; Region: WYL; pfam13280
541229002866	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
541229002867	RibD C-terminal domain; Region: RibD_C; cl17279
541229002868	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
541229002869	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229002870	dimerization interface [polypeptide binding]; other site
541229002871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229002872	dimer interface [polypeptide binding]; other site
541229002873	phosphorylation site [posttranslational modification]
541229002874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229002875	ATP binding site [chemical binding]; other site
541229002876	Mg2+ binding site [ion binding]; other site
541229002877	G-X-G motif; other site
541229002878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229002879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229002880	active site
541229002881	phosphorylation site [posttranslational modification]
541229002882	intermolecular recognition site; other site
541229002883	dimerization interface [polypeptide binding]; other site
541229002884	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229002885	DNA binding site [nucleotide binding]
541229002886	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
541229002887	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
541229002888	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
541229002889	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
541229002890	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
541229002891	Sulfate transporter family; Region: Sulfate_transp; pfam00916
541229002892	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
541229002893	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
541229002894	Ligand Binding Site [chemical binding]; other site
541229002895	Protein of unknown function (DUF4027); Region: DUF4027; pfam13219
541229002896	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
541229002897	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
541229002898	peptide binding site [polypeptide binding]; other site
541229002899	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
541229002900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002901	dimer interface [polypeptide binding]; other site
541229002902	conserved gate region; other site
541229002903	putative PBP binding loops; other site
541229002904	ABC-ATPase subunit interface; other site
541229002905	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
541229002906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229002907	putative PBP binding loops; other site
541229002908	ABC-ATPase subunit interface; other site
541229002909	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
541229002910	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229002911	Walker A/P-loop; other site
541229002912	ATP binding site [chemical binding]; other site
541229002913	Q-loop/lid; other site
541229002914	ABC transporter signature motif; other site
541229002915	Walker B; other site
541229002916	D-loop; other site
541229002917	H-loop/switch region; other site
541229002918	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
541229002919	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
541229002920	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229002921	Walker A/P-loop; other site
541229002922	ATP binding site [chemical binding]; other site
541229002923	Q-loop/lid; other site
541229002924	ABC transporter signature motif; other site
541229002925	Walker B; other site
541229002926	D-loop; other site
541229002927	H-loop/switch region; other site
541229002928	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
541229002929	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
541229002930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002931	putative substrate translocation pore; other site
541229002932	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229002933	MarR family; Region: MarR; pfam01047
541229002934	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
541229002935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002936	putative substrate translocation pore; other site
541229002937	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229002938	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229002939	DNA binding site [nucleotide binding]
541229002940	domain linker motif; other site
541229002941	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
541229002942	dimerization interface [polypeptide binding]; other site
541229002943	ligand binding site [chemical binding]; other site
541229002944	sodium binding site [ion binding]; other site
541229002945	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
541229002946	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
541229002947	substrate binding site [chemical binding]; other site
541229002948	dimer interface [polypeptide binding]; other site
541229002949	ATP binding site [chemical binding]; other site
541229002950	D-ribose pyranase; Provisional; Region: PRK11797
541229002951	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
541229002952	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
541229002953	Walker A/P-loop; other site
541229002954	ATP binding site [chemical binding]; other site
541229002955	Q-loop/lid; other site
541229002956	ABC transporter signature motif; other site
541229002957	Walker B; other site
541229002958	D-loop; other site
541229002959	H-loop/switch region; other site
541229002960	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
541229002961	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
541229002962	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
541229002963	TM-ABC transporter signature motif; other site
541229002964	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
541229002965	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
541229002966	ligand binding site [chemical binding]; other site
541229002967	dimerization interface [polypeptide binding]; other site
541229002968	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
541229002969	active site
541229002970	intersubunit interactions; other site
541229002971	catalytic residue [active]
541229002972	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
541229002973	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
541229002974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229002975	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229002976	putative substrate translocation pore; other site
541229002977	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
541229002978	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
541229002979	putative NAD(P) binding site [chemical binding]; other site
541229002980	catalytic Zn binding site [ion binding]; other site
541229002981	Ion channel; Region: Ion_trans_2; pfam07885
541229002982	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
541229002983	Zn binding site [ion binding]; other site
541229002984	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
541229002985	putative catalytic site [active]
541229002986	metal binding site A [ion binding]; metal-binding site
541229002987	phosphate binding site [ion binding]; other site
541229002988	metal binding site C [ion binding]; metal-binding site
541229002989	metal binding site B [ion binding]; metal-binding site
541229002990	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229002991	non-specific DNA binding site [nucleotide binding]; other site
541229002992	salt bridge; other site
541229002993	sequence-specific DNA binding site [nucleotide binding]; other site
541229002994	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229002995	sequence-specific DNA binding site [nucleotide binding]; other site
541229002996	salt bridge; other site
541229002997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229002998	non-specific DNA binding site [nucleotide binding]; other site
541229002999	salt bridge; other site
541229003000	sequence-specific DNA binding site [nucleotide binding]; other site
541229003001	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
541229003002	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
541229003003	DNA binding residues [nucleotide binding]
541229003004	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
541229003005	recombination and repair protein RecT; Reviewed; Region: recT; PRK09846
541229003006	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229003007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229003008	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
541229003009	Walker A motif; other site
541229003010	ATP binding site [chemical binding]; other site
541229003011	Walker B motif; other site
541229003012	Uncharacterized conserved protein [Function unknown]; Region: COG5582
541229003013	UPF0302 domain; Region: UPF0302; pfam08864
541229003014	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
541229003015	Homeodomain-like domain; Region: HTH_23; pfam13384
541229003016	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
541229003017	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229003018	Prophage antirepressor [Transcription]; Region: COG3617
541229003019	BRO family, N-terminal domain; Region: Bro-N; smart01040
541229003020	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
541229003021	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
541229003022	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229003023	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
541229003024	catalytic residues [active]
541229003025	catalytic nucleophile [active]
541229003026	Presynaptic Site I dimer interface [polypeptide binding]; other site
541229003027	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
541229003028	Synaptic Flat tetramer interface [polypeptide binding]; other site
541229003029	Synaptic Site I dimer interface [polypeptide binding]; other site
541229003030	DNA binding site [nucleotide binding]
541229003031	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
541229003032	DNA-binding interface [nucleotide binding]; DNA binding site
541229003033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
541229003034	Terminase-like family; Region: Terminase_6; pfam03237
541229003035	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
541229003036	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
541229003037	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
541229003038	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
541229003039	H-type lectin domain; Region: H_lectin; pfam09458
541229003040	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
541229003041	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
541229003042	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229003043	amidase catalytic site [active]
541229003044	Zn binding residues [ion binding]; other site
541229003045	substrate binding site [chemical binding]; other site
541229003046	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229003047	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
541229003048	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
541229003049	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229003050	Replication-relaxation; Region: Replic_Relax; pfam13814
541229003051	Helix-turn-helix domain; Region: HTH_36; pfam13730
541229003052	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
541229003053	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
541229003054	dimer interface [polypeptide binding]; other site
541229003055	active site
541229003056	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
541229003057	substrate binding site [chemical binding]; other site
541229003058	catalytic residue [active]
541229003059	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
541229003060	FAD binding domain; Region: FAD_binding_4; pfam01565
541229003061	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
541229003062	VanZ like family; Region: VanZ; pfam04892
541229003063	RDD family; Region: RDD; pfam06271
541229003064	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
541229003065	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
541229003066	Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044
541229003067	homodimer interface [polypeptide binding]; other site
541229003068	putative GKAP docking site [polypeptide binding]; other site
541229003069	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229003070	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229003071	dimer interface [polypeptide binding]; other site
541229003072	putative CheW interface [polypeptide binding]; other site
541229003073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
541229003074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
541229003075	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229003076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229003077	non-specific DNA binding site [nucleotide binding]; other site
541229003078	salt bridge; other site
541229003079	sequence-specific DNA binding site [nucleotide binding]; other site
541229003080	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
541229003081	active site
541229003082	catalytic site [active]
541229003083	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
541229003084	Archaeal flagella protein; Region: Arch_fla_DE; cl01322
541229003085	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
541229003086	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
541229003087	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
541229003088	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
541229003089	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229003090	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229003091	non-specific DNA binding site [nucleotide binding]; other site
541229003092	salt bridge; other site
541229003093	sequence-specific DNA binding site [nucleotide binding]; other site
541229003094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229003095	Coenzyme A binding pocket [chemical binding]; other site
541229003096	Protein of unknown function (DUF4022); Region: DUF4022; pfam13214
541229003097	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
541229003098	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
541229003099	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
541229003100	TrkA-N domain; Region: TrkA_N; pfam02254
541229003101	TrkA-C domain; Region: TrkA_C; pfam02080
541229003102	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
541229003103	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
541229003104	Subunit I/III interface [polypeptide binding]; other site
541229003105	Subunit III/IV interface [polypeptide binding]; other site
541229003106	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
541229003107	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
541229003108	D-pathway; other site
541229003109	Putative ubiquinol binding site [chemical binding]; other site
541229003110	Low-spin heme (heme b) binding site [chemical binding]; other site
541229003111	Putative water exit pathway; other site
541229003112	Binuclear center (heme o3/CuB) [ion binding]; other site
541229003113	K-pathway; other site
541229003114	Putative proton exit pathway; other site
541229003115	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
541229003116	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
541229003117	S-methylmethionine transporter; Provisional; Region: PRK11387
541229003118	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
541229003119	putative active site [active]
541229003120	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
541229003121	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
541229003122	metal binding site [ion binding]; metal-binding site
541229003123	dimer interface [polypeptide binding]; other site
541229003124	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
541229003125	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
541229003126	Na binding site [ion binding]; other site
541229003127	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229003128	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
541229003129	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
541229003130	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
541229003131	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
541229003132	Nucleoside recognition; Region: Gate; pfam07670
541229003133	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
541229003134	Nucleoside recognition; Region: Gate; pfam07670
541229003135	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
541229003136	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
541229003137	G1 box; other site
541229003138	GTP/Mg2+ binding site [chemical binding]; other site
541229003139	Switch I region; other site
541229003140	G2 box; other site
541229003141	G3 box; other site
541229003142	Switch II region; other site
541229003143	G4 box; other site
541229003144	G5 box; other site
541229003145	FeoA domain; Region: FeoA; pfam04023
541229003146	phosphate binding protein; Region: ptsS_2; TIGR02136
541229003147	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
541229003148	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
541229003149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003150	dimer interface [polypeptide binding]; other site
541229003151	conserved gate region; other site
541229003152	putative PBP binding loops; other site
541229003153	ABC-ATPase subunit interface; other site
541229003154	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
541229003155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003156	dimer interface [polypeptide binding]; other site
541229003157	conserved gate region; other site
541229003158	putative PBP binding loops; other site
541229003159	ABC-ATPase subunit interface; other site
541229003160	AAA domain; Region: AAA_33; pfam13671
541229003161	AAA domain; Region: AAA_17; pfam13207
541229003162	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
541229003163	Protein export membrane protein; Region: SecD_SecF; cl14618
541229003164	FOG: CBS domain [General function prediction only]; Region: COG0517
541229003165	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
541229003166	Domain of unknown function (DUF3960); Region: DUF3960; pfam13142
541229003167	Protein of unknown function (DUF3965); Region: DUF3965; pfam13112
541229003168	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229003169	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229003170	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229003171	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229003172	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229003173	Putative transcription activator [Transcription]; Region: TenA; COG0819
541229003174	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
541229003175	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
541229003176	Walker A/P-loop; other site
541229003177	ATP binding site [chemical binding]; other site
541229003178	Q-loop/lid; other site
541229003179	ABC transporter signature motif; other site
541229003180	Walker B; other site
541229003181	D-loop; other site
541229003182	H-loop/switch region; other site
541229003183	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
541229003184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003185	dimer interface [polypeptide binding]; other site
541229003186	conserved gate region; other site
541229003187	putative PBP binding loops; other site
541229003188	ABC-ATPase subunit interface; other site
541229003189	NMT1/THI5 like; Region: NMT1; pfam09084
541229003190	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
541229003191	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
541229003192	thiamine phosphate binding site [chemical binding]; other site
541229003193	active site
541229003194	pyrophosphate binding site [ion binding]; other site
541229003195	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
541229003196	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
541229003197	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
541229003198	thiS-thiF/thiG interaction site; other site
541229003199	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
541229003200	ThiS interaction site; other site
541229003201	putative active site [active]
541229003202	tetramer interface [polypeptide binding]; other site
541229003203	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
541229003204	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
541229003205	ATP binding site [chemical binding]; other site
541229003206	substrate interface [chemical binding]; other site
541229003207	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
541229003208	dimer interface [polypeptide binding]; other site
541229003209	substrate binding site [chemical binding]; other site
541229003210	ATP binding site [chemical binding]; other site
541229003211	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
541229003212	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
541229003213	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229003214	Soluble P-type ATPase [General function prediction only]; Region: COG4087
541229003215	potassium-transporting ATPase subunit C; Provisional; Region: PRK13997
541229003216	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
541229003217	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
541229003218	Ligand Binding Site [chemical binding]; other site
541229003219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003220	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229003221	putative substrate translocation pore; other site
541229003222	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229003223	MarR family; Region: MarR; pfam01047
541229003224	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
541229003225	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
541229003226	active site
541229003227	nucleophile elbow; other site
541229003228	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
541229003229	short chain dehydrogenase; Provisional; Region: PRK06701
541229003230	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
541229003231	NAD binding site [chemical binding]; other site
541229003232	metal binding site [ion binding]; metal-binding site
541229003233	active site
541229003234	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
541229003235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
541229003236	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
541229003237	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
541229003238	putative substrate binding site [chemical binding]; other site
541229003239	putative ATP binding site [chemical binding]; other site
541229003240	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
541229003241	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
541229003242	substrate binding [chemical binding]; other site
541229003243	active site
541229003244	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
541229003245	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
541229003246	active site turn [active]
541229003247	phosphorylation site [posttranslational modification]
541229003248	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
541229003249	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229003250	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
541229003251	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229003252	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229003253	DNA binding site [nucleotide binding]
541229003254	domain linker motif; other site
541229003255	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
541229003256	dimerization interface [polypeptide binding]; other site
541229003257	ligand binding site [chemical binding]; other site
541229003258	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
541229003259	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229003260	catalytic residues [active]
541229003261	putative disulfide oxidoreductase; Provisional; Region: PRK03113
541229003262	YhdB-like protein; Region: YhdB; pfam14148
541229003263	Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798
541229003264	Spore germination protein; Region: Spore_permease; pfam03845
541229003265	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229003266	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
541229003267	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
541229003268	putative FMN binding site [chemical binding]; other site
541229003269	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
541229003270	SpoVR like protein; Region: SpoVR; pfam04293
541229003271	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
541229003272	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229003273	MarR family; Region: MarR_2; pfam12802
541229003274	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
541229003275	Protein of unknown function (DUF3238); Region: DUF3238; pfam11579
541229003276	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
541229003277	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229003278	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229003279	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
541229003280	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
541229003281	active site residue [active]
541229003282	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
541229003283	putative homodimer interface [polypeptide binding]; other site
541229003284	putative homotetramer interface [polypeptide binding]; other site
541229003285	putative metal binding site [ion binding]; other site
541229003286	putative homodimer-homodimer interface [polypeptide binding]; other site
541229003287	putative allosteric switch controlling residues; other site
541229003288	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
541229003289	CPxP  motif; other site
541229003290	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
541229003291	active site residue [active]
541229003292	Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523
541229003293	active site residue [active]
541229003294	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
541229003295	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
541229003296	CPxP  motif; other site
541229003297	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
541229003298	active site residue [active]
541229003299	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
541229003300	active site residue [active]
541229003301	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
541229003302	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229003303	Transcriptional regulator [Transcription]; Region: LytR; COG1316
541229003304	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
541229003305	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
541229003306	NADP binding site [chemical binding]; other site
541229003307	dimer interface [polypeptide binding]; other site
541229003308	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
541229003309	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
541229003310	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
541229003311	PhoU domain; Region: PhoU; pfam01895
541229003312	PhoU domain; Region: PhoU; pfam01895
541229003313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003314	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229003315	putative substrate translocation pore; other site
541229003316	Uncharacterized conserved protein [Function unknown]; Region: COG3589
541229003317	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
541229003318	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
541229003319	HTH domain; Region: HTH_11; pfam08279
541229003320	Mga helix-turn-helix domain; Region: Mga; pfam05043
541229003321	PRD domain; Region: PRD; pfam00874
541229003322	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
541229003323	active site
541229003324	P-loop; other site
541229003325	phosphorylation site [posttranslational modification]
541229003326	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
541229003327	active site
541229003328	phosphorylation site [posttranslational modification]
541229003329	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
541229003330	active site
541229003331	methionine cluster; other site
541229003332	phosphorylation site [posttranslational modification]
541229003333	metal binding site [ion binding]; metal-binding site
541229003334	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
541229003335	active site
541229003336	P-loop; other site
541229003337	phosphorylation site [posttranslational modification]
541229003338	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
541229003339	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
541229003340	Uncharacterized conserved protein [Function unknown]; Region: COG3589
541229003341	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
541229003342	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229003343	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229003344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
541229003345	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
541229003346	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229003347	FtsX-like permease family; Region: FtsX; pfam02687
541229003348	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229003349	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229003350	Walker A/P-loop; other site
541229003351	ATP binding site [chemical binding]; other site
541229003352	Q-loop/lid; other site
541229003353	ABC transporter signature motif; other site
541229003354	Walker B; other site
541229003355	D-loop; other site
541229003356	H-loop/switch region; other site
541229003357	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
541229003358	HlyD family secretion protein; Region: HlyD_3; pfam13437
541229003359	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
541229003360	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
541229003361	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
541229003362	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229003363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003364	dimer interface [polypeptide binding]; other site
541229003365	conserved gate region; other site
541229003366	ABC-ATPase subunit interface; other site
541229003367	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
541229003368	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
541229003369	dimanganese center [ion binding]; other site
541229003370	CotJB protein; Region: CotJB; pfam12652
541229003371	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
541229003372	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229003373	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229003374	active site
541229003375	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
541229003376	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
541229003377	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
541229003378	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
541229003379	putative DNA binding site [nucleotide binding]; other site
541229003380	putative homodimer interface [polypeptide binding]; other site
541229003381	Uncharacterized conserved protein [Function unknown]; Region: COG3339
541229003382	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229003383	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229003384	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
541229003385	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
541229003386	Protein of unknown function (DUF3992); Region: DUF3992; pfam13157
541229003387	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229003388	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
541229003389	active site
541229003390	metal binding site [ion binding]; metal-binding site
541229003391	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229003392	Interdomain contacts; other site
541229003393	Cytokine receptor motif; other site
541229003394	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
541229003395	amino acid transporter; Region: 2A0306; TIGR00909
541229003396	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
541229003397	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
541229003398	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
541229003399	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
541229003400	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
541229003401	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
541229003402	putative active site [active]
541229003403	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
541229003404	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
541229003405	putative active site [active]
541229003406	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
541229003407	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
541229003408	active site turn [active]
541229003409	phosphorylation site [posttranslational modification]
541229003410	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229003411	Uncharacterized conserved protein [Function unknown]; Region: COG3589
541229003412	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
541229003413	DoxX; Region: DoxX; pfam07681
541229003414	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
541229003415	hypothetical protein; Provisional; Region: PRK06770
541229003416	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229003417	EamA-like transporter family; Region: EamA; pfam00892
541229003418	EamA-like transporter family; Region: EamA; pfam00892
541229003419	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
541229003420	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
541229003421	AsnC family; Region: AsnC_trans_reg; pfam01037
541229003422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229003423	Coenzyme A binding pocket [chemical binding]; other site
541229003424	short chain dehydrogenase; Provisional; Region: PRK06138
541229003425	classical (c) SDRs; Region: SDR_c; cd05233
541229003426	NAD(P) binding site [chemical binding]; other site
541229003427	active site
541229003428	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
541229003429	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
541229003430	DNA binding residues [nucleotide binding]
541229003431	putative dimer interface [polypeptide binding]; other site
541229003432	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229003433	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229003434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229003435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229003436	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229003437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003439	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229003440	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229003441	dimerization interface [polypeptide binding]; other site
541229003442	putative DNA binding site [nucleotide binding]; other site
541229003443	putative Zn2+ binding site [ion binding]; other site
541229003444	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
541229003445	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229003446	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
541229003447	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
541229003448	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
541229003449	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
541229003450	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229003451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003452	putative substrate translocation pore; other site
541229003453	intracellular protease, PfpI family; Region: PfpI; TIGR01382
541229003454	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
541229003455	proposed catalytic triad [active]
541229003456	conserved cys residue [active]
541229003457	hydroperoxidase II; Provisional; Region: katE; PRK11249
541229003458	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
541229003459	tetramer interface [polypeptide binding]; other site
541229003460	heme binding pocket [chemical binding]; other site
541229003461	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
541229003462	domain interactions; other site
541229003463	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
541229003464	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
541229003465	Spore germination protein; Region: Spore_permease; cl17796
541229003466	glutamate racemase; Provisional; Region: PRK00865
541229003467	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
541229003468	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
541229003469	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
541229003470	tetrameric interface [polypeptide binding]; other site
541229003471	activator binding site; other site
541229003472	NADP binding site [chemical binding]; other site
541229003473	substrate binding site [chemical binding]; other site
541229003474	catalytic residues [active]
541229003475	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229003476	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
541229003477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229003478	Walker A/P-loop; other site
541229003479	ATP binding site [chemical binding]; other site
541229003480	Q-loop/lid; other site
541229003481	ABC transporter signature motif; other site
541229003482	Walker B; other site
541229003483	D-loop; other site
541229003484	H-loop/switch region; other site
541229003485	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229003486	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
541229003487	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
541229003488	Walker A/P-loop; other site
541229003489	ATP binding site [chemical binding]; other site
541229003490	Q-loop/lid; other site
541229003491	ABC transporter signature motif; other site
541229003492	Walker B; other site
541229003493	D-loop; other site
541229003494	H-loop/switch region; other site
541229003495	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
541229003496	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229003497	substrate binding pocket [chemical binding]; other site
541229003498	membrane-bound complex binding site; other site
541229003499	hinge residues; other site
541229003500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003501	dimer interface [polypeptide binding]; other site
541229003502	conserved gate region; other site
541229003503	putative PBP binding loops; other site
541229003504	ABC-ATPase subunit interface; other site
541229003505	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
541229003506	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
541229003507	Walker A/P-loop; other site
541229003508	ATP binding site [chemical binding]; other site
541229003509	Q-loop/lid; other site
541229003510	ABC transporter signature motif; other site
541229003511	Walker B; other site
541229003512	D-loop; other site
541229003513	H-loop/switch region; other site
541229003514	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
541229003515	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
541229003516	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
541229003517	Protein of unknown function (DUF445); Region: DUF445; pfam04286
541229003518	hypothetical protein; Provisional; Region: PRK13676
541229003519	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
541229003520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229003521	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229003522	Probable transposase; Region: OrfB_IS605; pfam01385
541229003523	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229003524	acetolactate synthase; Reviewed; Region: PRK08617
541229003525	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
541229003526	PYR/PP interface [polypeptide binding]; other site
541229003527	dimer interface [polypeptide binding]; other site
541229003528	TPP binding site [chemical binding]; other site
541229003529	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
541229003530	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
541229003531	TPP-binding site [chemical binding]; other site
541229003532	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
541229003533	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
541229003534	active site
541229003535	DNA binding site [nucleotide binding]
541229003536	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
541229003537	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
541229003538	active site
541229003539	motif I; other site
541229003540	motif II; other site
541229003541	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
541229003542	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
541229003543	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
541229003544	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003545	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003546	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003547	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003548	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003549	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003550	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003551	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229003552	amidase catalytic site [active]
541229003553	Zn binding residues [ion binding]; other site
541229003554	substrate binding site [chemical binding]; other site
541229003555	S-layer homology domain; Region: SLH; pfam00395
541229003556	S-layer homology domain; Region: SLH; pfam00395
541229003557	S-layer homology domain; Region: SLH; pfam00395
541229003558	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
541229003559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229003560	FeS/SAM binding site; other site
541229003561	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
541229003562	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
541229003563	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
541229003564	acyl-activating enzyme (AAE) consensus motif; other site
541229003565	acyl-activating enzyme (AAE) consensus motif; other site
541229003566	putative AMP binding site [chemical binding]; other site
541229003567	putative active site [active]
541229003568	putative CoA binding site [chemical binding]; other site
541229003569	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
541229003570	Sulfate transporter family; Region: Sulfate_transp; pfam00916
541229003571	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
541229003572	stage V sporulation protein B; Region: spore_V_B; TIGR02900
541229003573	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
541229003574	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
541229003575	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
541229003576	S-layer homology domain; Region: SLH; pfam00395
541229003577	S-layer homology domain; Region: SLH; pfam00395
541229003578	S-layer homology domain; Region: SLH; pfam00395
541229003579	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
541229003580	O-Antigen ligase; Region: Wzy_C; cl04850
541229003581	enoyl-CoA hydratase; Provisional; Region: PRK07659
541229003582	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
541229003583	substrate binding site [chemical binding]; other site
541229003584	oxyanion hole (OAH) forming residues; other site
541229003585	trimer interface [polypeptide binding]; other site
541229003586	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
541229003587	metal binding site [ion binding]; metal-binding site
541229003588	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
541229003589	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
541229003590	putative oligomer interface [polypeptide binding]; other site
541229003591	putative active site [active]
541229003592	metal binding site [ion binding]; metal-binding site
541229003593	S-layer homology domain; Region: SLH; pfam00395
541229003594	S-layer homology domain; Region: SLH; pfam00395
541229003595	S-layer homology domain; Region: SLH; pfam00395
541229003596	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
541229003597	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
541229003598	active site
541229003599	metal binding site [ion binding]; metal-binding site
541229003600	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
541229003601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229003602	S-adenosylmethionine binding site [chemical binding]; other site
541229003603	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
541229003604	proline racemase; Provisional; Region: PRK13969
541229003605	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
541229003606	ornithine cyclodeaminase; Validated; Region: PRK08618
541229003607	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
541229003608	NAD(P) binding site [chemical binding]; other site
541229003609	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
541229003610	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
541229003611	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
541229003612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003613	dimer interface [polypeptide binding]; other site
541229003614	conserved gate region; other site
541229003615	putative PBP binding loops; other site
541229003616	ABC-ATPase subunit interface; other site
541229003617	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229003618	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
541229003619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229003620	dimer interface [polypeptide binding]; other site
541229003621	conserved gate region; other site
541229003622	putative PBP binding loops; other site
541229003623	ABC-ATPase subunit interface; other site
541229003624	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
541229003625	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229003626	Walker A/P-loop; other site
541229003627	ATP binding site [chemical binding]; other site
541229003628	Q-loop/lid; other site
541229003629	ABC transporter signature motif; other site
541229003630	Walker B; other site
541229003631	D-loop; other site
541229003632	H-loop/switch region; other site
541229003633	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
541229003634	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229003635	Q-loop/lid; other site
541229003636	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
541229003637	ABC transporter signature motif; other site
541229003638	Walker B; other site
541229003639	D-loop; other site
541229003640	H-loop/switch region; other site
541229003641	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
541229003642	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
541229003643	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
541229003644	catalytic residues [active]
541229003645	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
541229003646	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
541229003647	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
541229003648	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
541229003649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003650	putative substrate translocation pore; other site
541229003651	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
541229003652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229003653	putative active site [active]
541229003654	heme pocket [chemical binding]; other site
541229003655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229003656	ATP binding site [chemical binding]; other site
541229003657	Mg2+ binding site [ion binding]; other site
541229003658	G-X-G motif; other site
541229003659	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
541229003660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229003661	active site
541229003662	phosphorylation site [posttranslational modification]
541229003663	intermolecular recognition site; other site
541229003664	dimerization interface [polypeptide binding]; other site
541229003665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
541229003666	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
541229003667	active site
541229003668	8-oxo-dGMP binding site [chemical binding]; other site
541229003669	nudix motif; other site
541229003670	metal binding site [ion binding]; metal-binding site
541229003671	PLD-like domain; Region: PLDc_2; pfam13091
541229003672	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
541229003673	putative homodimer interface [polypeptide binding]; other site
541229003674	putative active site [active]
541229003675	catalytic site [active]
541229003676	DEAD-like helicases superfamily; Region: DEXDc; smart00487
541229003677	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229003678	ATP binding site [chemical binding]; other site
541229003679	putative Mg++ binding site [ion binding]; other site
541229003680	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
541229003681	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229003682	nucleotide binding region [chemical binding]; other site
541229003683	ATP-binding site [chemical binding]; other site
541229003684	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
541229003685	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229003686	replicative DNA helicase; Provisional; Region: PRK06749
541229003687	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
541229003688	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
541229003689	Walker A motif; other site
541229003690	ATP binding site [chemical binding]; other site
541229003691	Walker B motif; other site
541229003692	DNA binding loops [nucleotide binding]
541229003693	Uncharacterized conserved protein [Function unknown]; Region: COG5464
541229003694	Predicted transcriptional regulators [Transcription]; Region: COG1378
541229003695	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
541229003696	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
541229003697	C-terminal domain interface [polypeptide binding]; other site
541229003698	sugar binding site [chemical binding]; other site
541229003699	hypothetical protein; Provisional; Region: PRK10621
541229003700	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229003701	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229003702	EamA-like transporter family; Region: EamA; pfam00892
541229003703	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229003704	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229003705	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
541229003706	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
541229003707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003708	putative substrate translocation pore; other site
541229003709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003710	hypothetical protein; Provisional; Region: PRK06770
541229003711	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
541229003712	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
541229003713	active site
541229003714	catalytic site [active]
541229003715	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229003716	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229003717	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
541229003718	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
541229003719	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
541229003720	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
541229003721	CGNR zinc finger; Region: zf-CGNR; pfam11706
541229003722	HPP family; Region: HPP; pfam04982
541229003723	YmzC-like protein; Region: YmzC; pfam14157
541229003724	Transcriptional regulators [Transcription]; Region: MarR; COG1846
541229003725	MarR family; Region: MarR_2; pfam12802
541229003726	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
541229003727	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
541229003728	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229003729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229003730	putative substrate translocation pore; other site
541229003731	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229003732	putative DNA binding site [nucleotide binding]; other site
541229003733	dimerization interface [polypeptide binding]; other site
541229003734	putative Zn2+ binding site [ion binding]; other site
541229003735	VanZ like family; Region: VanZ; pfam04892
541229003736	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
541229003737	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
541229003738	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
541229003739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229003740	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
541229003741	dihydroxyacetone kinase; Provisional; Region: PRK14479
541229003742	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
541229003743	DAK2 domain; Region: Dak2; pfam02734
541229003744	Bacterial SH3 domain; Region: SH3_3; cl17532
541229003745	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
541229003746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229003747	non-specific DNA binding site [nucleotide binding]; other site
541229003748	salt bridge; other site
541229003749	sequence-specific DNA binding site [nucleotide binding]; other site
541229003750	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229003751	transposase/IS protein; Provisional; Region: PRK09183
541229003752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229003753	Walker A motif; other site
541229003754	ATP binding site [chemical binding]; other site
541229003755	Walker B motif; other site
541229003756	arginine finger; other site
541229003757	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229003758	Integrase core domain; Region: rve; pfam00665
541229003759	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229003760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229003761	TPR motif; other site
541229003762	binding surface
541229003763	S-layer homology domain; Region: SLH; pfam00395
541229003764	S-layer homology domain; Region: SLH; pfam00395
541229003765	S-layer homology domain; Region: SLH; pfam00395
541229003766	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
541229003767	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229003768	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229003769	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
541229003770	Putative zinc-finger; Region: zf-HC2; pfam13490
541229003771	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
541229003772	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
541229003773	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229003774	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229003775	DNA binding residues [nucleotide binding]
541229003776	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229003777	Predicted membrane protein [Function unknown]; Region: COG2261
541229003778	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
541229003779	anti sigma factor interaction site; other site
541229003780	regulatory phosphorylation site [posttranslational modification]; other site
541229003781	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
541229003782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229003783	ATP binding site [chemical binding]; other site
541229003784	Mg2+ binding site [ion binding]; other site
541229003785	G-X-G motif; other site
541229003786	RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941
541229003787	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229003788	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
541229003789	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229003790	DNA binding residues [nucleotide binding]
541229003791	Ferritin-like domain; Region: Ferritin; pfam00210
541229003792	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
541229003793	dinuclear metal binding motif [ion binding]; other site
541229003794	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
541229003795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229003796	active site
541229003797	phosphorylation site [posttranslational modification]
541229003798	intermolecular recognition site; other site
541229003799	dimerization interface [polypeptide binding]; other site
541229003800	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
541229003801	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
541229003802	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
541229003803	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
541229003804	CHASE3 domain; Region: CHASE3; pfam05227
541229003805	GAF domain; Region: GAF_2; pfam13185
541229003806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229003807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229003808	dimer interface [polypeptide binding]; other site
541229003809	phosphorylation site [posttranslational modification]
541229003810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229003811	ATP binding site [chemical binding]; other site
541229003812	Mg2+ binding site [ion binding]; other site
541229003813	G-X-G motif; other site
541229003814	Response regulator receiver domain; Region: Response_reg; pfam00072
541229003815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229003816	active site
541229003817	phosphorylation site [posttranslational modification]
541229003818	intermolecular recognition site; other site
541229003819	dimerization interface [polypeptide binding]; other site
541229003820	Protein of unknown function (DUF4028); Region: DUF4028; pfam13220
541229003821	hypothetical protein; Provisional; Region: PRK12856
541229003822	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229003823	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229003824	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229003825	Transposase; Region: HTH_Tnp_1; cl17663
541229003826	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229003827	putative transposase OrfB; Reviewed; Region: PHA02517
541229003828	HTH-like domain; Region: HTH_21; pfam13276
541229003829	Integrase core domain; Region: rve; pfam00665
541229003830	Integrase core domain; Region: rve_2; pfam13333
541229003831	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229003832	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229003833	putative active site [active]
541229003834	putative NTP binding site [chemical binding]; other site
541229003835	putative nucleic acid binding site [nucleotide binding]; other site
541229003836	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229003837	active site
541229003838	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229003839	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
541229003840	NADP binding site [chemical binding]; other site
541229003841	dimer interface [polypeptide binding]; other site
541229003842	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
541229003843	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
541229003844	active site
541229003845	Protein of unknown function (DUF2639); Region: DUF2639; pfam11121
541229003846	YhzD-like protein; Region: YhzD; pfam14120
541229003847	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
541229003848	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229003849	active site
541229003850	metal binding site [ion binding]; metal-binding site
541229003851	DNA binding site [nucleotide binding]
541229003852	AAA domain; Region: AAA_27; pfam13514
541229003853	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
541229003854	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
541229003855	generic binding surface II; other site
541229003856	generic binding surface I; other site
541229003857	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229003858	Zn2+ binding site [ion binding]; other site
541229003859	Mg2+ binding site [ion binding]; other site
541229003860	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
541229003861	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
541229003862	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
541229003863	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229003864	Zn binding site [ion binding]; other site
541229003865	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
541229003866	Zn binding site [ion binding]; other site
541229003867	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
541229003868	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229003869	Zn binding site [ion binding]; other site
541229003870	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
541229003871	Zn binding site [ion binding]; other site
541229003872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
541229003873	TPR motif; other site
541229003874	binding surface
541229003875	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229003876	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
541229003877	Sporulation protein YhaL; Region: Spore_YhaL; pfam14147
541229003878	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
541229003879	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
541229003880	Domain of unknown function (DUF3994); Region: DUF3994; pfam13159
541229003881	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
541229003882	Cupin; Region: Cupin_1; smart00835
541229003883	Cupin; Region: Cupin_1; smart00835
541229003884	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229003885	non-specific DNA binding site [nucleotide binding]; other site
541229003886	salt bridge; other site
541229003887	sequence-specific DNA binding site [nucleotide binding]; other site
541229003888	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
541229003889	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
541229003890	amphipathic channel; other site
541229003891	Asn-Pro-Ala signature motifs; other site
541229003892	glycerol kinase; Provisional; Region: glpK; PRK00047
541229003893	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
541229003894	N- and C-terminal domain interface [polypeptide binding]; other site
541229003895	active site
541229003896	MgATP binding site [chemical binding]; other site
541229003897	catalytic site [active]
541229003898	metal binding site [ion binding]; metal-binding site
541229003899	glycerol binding site [chemical binding]; other site
541229003900	homotetramer interface [polypeptide binding]; other site
541229003901	homodimer interface [polypeptide binding]; other site
541229003902	FBP binding site [chemical binding]; other site
541229003903	protein IIAGlc interface [polypeptide binding]; other site
541229003904	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
541229003905	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229003906	Transcriptional regulator PadR-like family; Region: PadR; cl17335
541229003907	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
541229003908	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229003909	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229003910	DNA binding residues [nucleotide binding]
541229003911	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
541229003912	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229003913	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
541229003914	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
541229003915	Part of AAA domain; Region: AAA_19; pfam13245
541229003916	Family description; Region: UvrD_C_2; pfam13538
541229003917	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
541229003918	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
541229003919	Protein of unknown function (DUF1878); Region: DUF1878; pfam08963
541229003920	transcriptional regulator Hpr; Provisional; Region: PRK13777
541229003921	MarR family; Region: MarR; pfam01047
541229003922	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
541229003923	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
541229003924	HIT family signature motif; other site
541229003925	catalytic residue [active]
541229003926	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229003927	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229003928	Walker A/P-loop; other site
541229003929	ATP binding site [chemical binding]; other site
541229003930	Q-loop/lid; other site
541229003931	ABC transporter signature motif; other site
541229003932	Walker B; other site
541229003933	D-loop; other site
541229003934	H-loop/switch region; other site
541229003935	potential frameshift: common BLAST hit: gi|296501764|ref|YP_003663464.1| protein EcsB
541229003936	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
541229003937	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
541229003938	EcsC protein family; Region: EcsC; pfam12787
541229003939	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
541229003940	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
541229003941	nucleophilic elbow; other site
541229003942	catalytic triad; other site
541229003943	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229003944	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229003945	Uncharacterized conserved protein [Function unknown]; Region: COG3402
541229003946	Predicted membrane protein [Function unknown]; Region: COG3428
541229003947	Bacterial PH domain; Region: DUF304; pfam03703
541229003948	Bacterial PH domain; Region: DUF304; cl01348
541229003949	Bacterial PH domain; Region: DUF304; pfam03703
541229003950	Protein of unknown function (DUF975); Region: DUF975; cl10504
541229003951	Protein of unknown function (DUF975); Region: DUF975; cl10504
541229003952	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
541229003953	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229003954	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229003955	Collagen binding domain; Region: Collagen_bind; pfam05737
541229003956	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
541229003957	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003958	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003959	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003960	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003961	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003962	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003963	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003964	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003965	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003966	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003967	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003968	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003969	Cna protein B-type domain; Region: Cna_B; pfam05738
541229003970	Biofilm formation and stress response factor; Region: BsmA; pfam10014
541229003971	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
541229003972	classical (c) SDRs; Region: SDR_c; cd05233
541229003973	NAD(P) binding site [chemical binding]; other site
541229003974	active site
541229003975	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229003976	EamA-like transporter family; Region: EamA; pfam00892
541229003977	EamA-like transporter family; Region: EamA; pfam00892
541229003978	Uncharacterized conserved protein [Function unknown]; Region: COG3402
541229003979	Bacterial PH domain; Region: DUF304; pfam03703
541229003980	Bacterial PH domain; Region: DUF304; pfam03703
541229003981	Bacterial PH domain; Region: DUF304; pfam03703
541229003982	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
541229003983	Transglycosylase; Region: Transgly; pfam00912
541229003984	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
541229003985	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229003986	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
541229003987	substrate binding site [chemical binding]; other site
541229003988	active site
541229003989	ferrochelatase; Provisional; Region: PRK12435
541229003990	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
541229003991	C-terminal domain interface [polypeptide binding]; other site
541229003992	active site
541229003993	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
541229003994	active site
541229003995	N-terminal domain interface [polypeptide binding]; other site
541229003996	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
541229003997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229003998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229003999	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
541229004000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
541229004001	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
541229004002	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
541229004003	generic binding surface I; other site
541229004004	generic binding surface II; other site
541229004005	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
541229004006	putative active site [active]
541229004007	putative catalytic site [active]
541229004008	putative Mg binding site IVb [ion binding]; other site
541229004009	putative phosphate binding site [ion binding]; other site
541229004010	putative DNA binding site [nucleotide binding]; other site
541229004011	putative Mg binding site IVa [ion binding]; other site
541229004012	Penicillinase repressor; Region: Pencillinase_R; pfam03965
541229004013	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
541229004014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229004015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229004016	Predicted membrane protein [Function unknown]; Region: COG1511
541229004017	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
541229004018	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
541229004019	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
541229004020	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
541229004021	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
541229004022	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589
541229004023	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229004024	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229004025	Coenzyme A binding pocket [chemical binding]; other site
541229004026	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229004027	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229004028	DNA binding site [nucleotide binding]
541229004029	domain linker motif; other site
541229004030	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
541229004031	putative dimerization interface [polypeptide binding]; other site
541229004032	putative ligand binding site [chemical binding]; other site
541229004033	YhfH-like protein; Region: YhfH; pfam14149
541229004034	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
541229004035	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
541229004036	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
541229004037	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
541229004038	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
541229004039	acyl-activating enzyme (AAE) consensus motif; other site
541229004040	putative AMP binding site [chemical binding]; other site
541229004041	putative active site [active]
541229004042	putative CoA binding site [chemical binding]; other site
541229004043	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
541229004044	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229004045	substrate binding pocket [chemical binding]; other site
541229004046	membrane-bound complex binding site; other site
541229004047	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
541229004048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004049	dimer interface [polypeptide binding]; other site
541229004050	conserved gate region; other site
541229004051	putative PBP binding loops; other site
541229004052	ABC-ATPase subunit interface; other site
541229004053	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
541229004054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004055	dimer interface [polypeptide binding]; other site
541229004056	conserved gate region; other site
541229004057	putative PBP binding loops; other site
541229004058	ABC-ATPase subunit interface; other site
541229004059	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
541229004060	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
541229004061	Walker A/P-loop; other site
541229004062	ATP binding site [chemical binding]; other site
541229004063	Q-loop/lid; other site
541229004064	ABC transporter signature motif; other site
541229004065	Walker B; other site
541229004066	D-loop; other site
541229004067	H-loop/switch region; other site
541229004068	TOBE-like domain; Region: TOBE_3; pfam12857
541229004069	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
541229004070	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
541229004071	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229004072	putative active site [active]
541229004073	putative metal binding site [ion binding]; other site
541229004074	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
541229004075	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229004076	Zn2+ binding site [ion binding]; other site
541229004077	Mg2+ binding site [ion binding]; other site
541229004078	Putative zinc-finger; Region: zf-HC2; pfam13490
541229004079	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
541229004080	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
541229004081	RNA polymerase sigma factor; Provisional; Region: PRK12541
541229004082	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229004083	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229004084	DNA binding residues [nucleotide binding]
541229004085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229004086	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
541229004087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229004088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
541229004089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229004090	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229004091	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229004092	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229004093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229004094	dimer interface [polypeptide binding]; other site
541229004095	phosphorylation site [posttranslational modification]
541229004096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229004097	ATP binding site [chemical binding]; other site
541229004098	Mg2+ binding site [ion binding]; other site
541229004099	G-X-G motif; other site
541229004100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229004101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229004102	active site
541229004103	phosphorylation site [posttranslational modification]
541229004104	intermolecular recognition site; other site
541229004105	dimerization interface [polypeptide binding]; other site
541229004106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229004107	DNA binding site [nucleotide binding]
541229004108	CAAX protease self-immunity; Region: Abi; pfam02517
541229004109	Peptidase family M48; Region: Peptidase_M48; pfam01435
541229004110	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
541229004111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229004112	dimerization interface [polypeptide binding]; other site
541229004113	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229004114	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229004115	dimer interface [polypeptide binding]; other site
541229004116	putative CheW interface [polypeptide binding]; other site
541229004117	S-layer homology domain; Region: SLH; pfam00395
541229004118	S-layer homology domain; Region: SLH; pfam00395
541229004119	S-layer homology domain; Region: SLH; pfam00395
541229004120	S-layer homology domain; Region: SLH; pfam00395
541229004121	S-layer homology domain; Region: SLH; pfam00395
541229004122	S-layer homology domain; Region: SLH; pfam00395
541229004123	malate synthase A; Region: malate_syn_A; TIGR01344
541229004124	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
541229004125	active site
541229004126	isocitrate lyase; Provisional; Region: PRK15063
541229004127	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
541229004128	tetramer interface [polypeptide binding]; other site
541229004129	active site
541229004130	Mg2+/Mn2+ binding site [ion binding]; other site
541229004131	Phosphotransferase enzyme family; Region: APH; pfam01636
541229004132	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
541229004133	active site
541229004134	substrate binding site [chemical binding]; other site
541229004135	ATP binding site [chemical binding]; other site
541229004136	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
541229004137	DNA-binding site [nucleotide binding]; DNA binding site
541229004138	RNA-binding motif; other site
541229004139	ComK protein; Region: ComK; pfam06338
541229004140	Uncharacterized conserved protein [Function unknown]; Region: COG0398
541229004141	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229004142	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
541229004143	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229004144	Catalytic site [active]
541229004145	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229004146	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
541229004147	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
541229004148	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
541229004149	Part of AAA domain; Region: AAA_19; pfam13245
541229004150	Family description; Region: UvrD_C_2; pfam13538
541229004151	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
541229004152	hypothetical protein; Provisional; Region: PRK07758
541229004153	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
541229004154	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
541229004155	Spore germination protein GerPC; Region: GerPC; pfam10737
541229004156	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
541229004157	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
541229004158	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
541229004159	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
541229004160	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
541229004161	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
541229004162	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229004163	inhibitor-cofactor binding pocket; inhibition site
541229004164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229004165	catalytic residue [active]
541229004166	hypothetical protein; Provisional; Region: PRK13673
541229004167	Protein of unknown function (DUF2777); Region: DUF2777; pfam10949
541229004168	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
541229004169	active site
541229004170	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
541229004171	dimer interface [polypeptide binding]; other site
541229004172	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
541229004173	Ligand Binding Site [chemical binding]; other site
541229004174	Molecular Tunnel; other site
541229004175	ferrochelatase; Provisional; Region: PRK12435
541229004176	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
541229004177	C-terminal domain interface [polypeptide binding]; other site
541229004178	active site
541229004179	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
541229004180	active site
541229004181	N-terminal domain interface [polypeptide binding]; other site
541229004182	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
541229004183	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
541229004184	tetramer interface [polypeptide binding]; other site
541229004185	heme binding pocket [chemical binding]; other site
541229004186	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
541229004187	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
541229004188	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
541229004189	active site
541229004190	catalytic site [active]
541229004191	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229004192	non-specific DNA binding site [nucleotide binding]; other site
541229004193	salt bridge; other site
541229004194	sequence-specific DNA binding site [nucleotide binding]; other site
541229004195	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229004196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
541229004197	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
541229004198	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
541229004199	S1 domain; Region: S1_2; pfam13509
541229004200	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
541229004201	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
541229004202	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229004203	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229004204	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229004205	Protein of unknown function (DUF3813); Region: DUF3813; pfam12758
541229004206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229004207	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229004208	active site
541229004209	motif I; other site
541229004210	motif II; other site
541229004211	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
541229004212	YjzC-like protein; Region: YjzC; pfam14168
541229004213	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
541229004214	Clp amino terminal domain; Region: Clp_N; pfam02861
541229004215	Clp amino terminal domain; Region: Clp_N; pfam02861
541229004216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229004217	Walker A motif; other site
541229004218	ATP binding site [chemical binding]; other site
541229004219	Walker B motif; other site
541229004220	arginine finger; other site
541229004221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229004222	Walker A motif; other site
541229004223	ATP binding site [chemical binding]; other site
541229004224	Walker B motif; other site
541229004225	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
541229004226	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
541229004227	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229004228	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
541229004229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229004230	NAD(P) binding site [chemical binding]; other site
541229004231	active site
541229004232	ComZ; Region: ComZ; pfam10815
541229004233	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
541229004234	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
541229004235	dimer interface [polypeptide binding]; other site
541229004236	active site
541229004237	CoA binding pocket [chemical binding]; other site
541229004238	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
541229004239	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
541229004240	dimer interface [polypeptide binding]; other site
541229004241	active site
541229004242	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
541229004243	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
541229004244	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
541229004245	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
541229004246	active site
541229004247	HIGH motif; other site
541229004248	dimer interface [polypeptide binding]; other site
541229004249	KMSKS motif; other site
541229004250	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
541229004251	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229004252	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229004253	peptide binding site [polypeptide binding]; other site
541229004254	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
541229004255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004256	dimer interface [polypeptide binding]; other site
541229004257	conserved gate region; other site
541229004258	putative PBP binding loops; other site
541229004259	ABC-ATPase subunit interface; other site
541229004260	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229004261	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
541229004262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004263	dimer interface [polypeptide binding]; other site
541229004264	conserved gate region; other site
541229004265	putative PBP binding loops; other site
541229004266	ABC-ATPase subunit interface; other site
541229004267	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
541229004268	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229004269	Walker A/P-loop; other site
541229004270	ATP binding site [chemical binding]; other site
541229004271	Q-loop/lid; other site
541229004272	ABC transporter signature motif; other site
541229004273	Walker B; other site
541229004274	D-loop; other site
541229004275	H-loop/switch region; other site
541229004276	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
541229004277	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
541229004278	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
541229004279	Walker A/P-loop; other site
541229004280	ATP binding site [chemical binding]; other site
541229004281	Q-loop/lid; other site
541229004282	ABC transporter signature motif; other site
541229004283	Walker B; other site
541229004284	D-loop; other site
541229004285	H-loop/switch region; other site
541229004286	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
541229004287	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
541229004288	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
541229004289	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229004290	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229004291	peptide binding site [polypeptide binding]; other site
541229004292	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
541229004293	ArsC family; Region: ArsC; pfam03960
541229004294	putative catalytic residues [active]
541229004295	thiol/disulfide switch; other site
541229004296	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
541229004297	adaptor protein; Provisional; Region: PRK02315
541229004298	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
541229004299	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
541229004300	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
541229004301	putative active site [active]
541229004302	catalytic site [active]
541229004303	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
541229004304	putative active site [active]
541229004305	catalytic site [active]
541229004306	Competence protein CoiA-like family; Region: CoiA; cl11541
541229004307	oligoendopeptidase F; Region: pepF; TIGR00181
541229004308	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
541229004309	active site
541229004310	Zn binding site [ion binding]; other site
541229004311	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
541229004312	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
541229004313	catalytic residues [active]
541229004314	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
541229004315	apolar tunnel; other site
541229004316	heme binding site [chemical binding]; other site
541229004317	dimerization interface [polypeptide binding]; other site
541229004318	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
541229004319	putative active site [active]
541229004320	putative metal binding residues [ion binding]; other site
541229004321	signature motif; other site
541229004322	putative triphosphate binding site [ion binding]; other site
541229004323	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
541229004324	synthetase active site [active]
541229004325	NTP binding site [chemical binding]; other site
541229004326	metal binding site [ion binding]; metal-binding site
541229004327	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
541229004328	ATP-NAD kinase; Region: NAD_kinase; pfam01513
541229004329	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
541229004330	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
541229004331	active site
541229004332	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
541229004333	trimer interface [polypeptide binding]; other site
541229004334	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
541229004335	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
541229004336	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
541229004337	active site
541229004338	metal binding site [ion binding]; metal-binding site
541229004339	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
541229004340	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
541229004341	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229004342	active site
541229004343	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229004344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229004345	S-adenosylmethionine binding site [chemical binding]; other site
541229004346	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
541229004347	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229004348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229004349	S-adenosylmethionine binding site [chemical binding]; other site
541229004350	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
541229004351	catalytic residues [active]
541229004352	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
541229004353	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
541229004354	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229004355	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
541229004356	active site
541229004357	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
541229004358	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
541229004359	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
541229004360	NAD binding site [chemical binding]; other site
541229004361	substrate binding site [chemical binding]; other site
541229004362	homodimer interface [polypeptide binding]; other site
541229004363	active site
541229004364	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
541229004365	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
541229004366	NADP binding site [chemical binding]; other site
541229004367	active site
541229004368	putative substrate binding site [chemical binding]; other site
541229004369	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
541229004370	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
541229004371	NAD binding site [chemical binding]; other site
541229004372	homotetramer interface [polypeptide binding]; other site
541229004373	homodimer interface [polypeptide binding]; other site
541229004374	substrate binding site [chemical binding]; other site
541229004375	active site
541229004376	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
541229004377	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
541229004378	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
541229004379	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
541229004380	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
541229004381	Part of AAA domain; Region: AAA_19; pfam13245
541229004382	Family description; Region: UvrD_C_2; pfam13538
541229004383	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229004384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229004385	Coenzyme A binding pocket [chemical binding]; other site
541229004386	hypothetical protein; Provisional; Region: PRK13679
541229004387	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
541229004388	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
541229004389	Putative esterase; Region: Esterase; pfam00756
541229004390	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229004391	EamA-like transporter family; Region: EamA; pfam00892
541229004392	EamA-like transporter family; Region: EamA; pfam00892
541229004393	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
541229004394	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
541229004395	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
541229004396	Na binding site [ion binding]; other site
541229004397	anthranilate synthase component I; Provisional; Region: PRK13570
541229004398	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
541229004399	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
541229004400	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
541229004401	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
541229004402	glutamine binding [chemical binding]; other site
541229004403	catalytic triad [active]
541229004404	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
541229004405	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
541229004406	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
541229004407	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
541229004408	active site
541229004409	ribulose/triose binding site [chemical binding]; other site
541229004410	phosphate binding site [ion binding]; other site
541229004411	substrate (anthranilate) binding pocket [chemical binding]; other site
541229004412	product (indole) binding pocket [chemical binding]; other site
541229004413	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
541229004414	active site
541229004415	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
541229004416	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
541229004417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229004418	catalytic residue [active]
541229004419	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
541229004420	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
541229004421	substrate binding site [chemical binding]; other site
541229004422	active site
541229004423	catalytic residues [active]
541229004424	heterodimer interface [polypeptide binding]; other site
541229004425	Protein of unknown function (DUF4029); Region: DUF4029; pfam13221
541229004426	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
541229004427	L-lactate permease; Region: Lactate_perm; cl00701
541229004428	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
541229004429	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
541229004430	Double zinc ribbon; Region: DZR; pfam12773
541229004431	Predicted membrane protein [Function unknown]; Region: COG4640
541229004432	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
541229004433	YARHG domain; Region: YARHG; pfam13308
541229004434	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
541229004435	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229004436	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229004437	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
541229004438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229004439	Coenzyme A binding pocket [chemical binding]; other site
541229004440	Protein of unknown function (DUF3908); Region: DUF3908; pfam13048
541229004441	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229004442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229004443	S-adenosylmethionine binding site [chemical binding]; other site
541229004444	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
541229004445	NADPH bind site [chemical binding]; other site
541229004446	putative FMN binding site [chemical binding]; other site
541229004447	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
541229004448	putative FMN binding site [chemical binding]; other site
541229004449	NADPH bind site [chemical binding]; other site
541229004450	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
541229004451	YcaO-like family; Region: YcaO; pfam02624
541229004452	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
541229004453	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
541229004454	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
541229004455	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
541229004456	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
541229004457	E3 interaction surface; other site
541229004458	lipoyl attachment site [posttranslational modification]; other site
541229004459	e3 binding domain; Region: E3_binding; pfam02817
541229004460	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
541229004461	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
541229004462	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
541229004463	TPP-binding site [chemical binding]; other site
541229004464	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
541229004465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229004466	salt bridge; other site
541229004467	non-specific DNA binding site [nucleotide binding]; other site
541229004468	sequence-specific DNA binding site [nucleotide binding]; other site
541229004469	Domain of unknown function (DUF3976); Region: DUF3976; pfam13121
541229004470	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229004471	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
541229004472	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
541229004473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229004474	S-adenosylmethionine binding site [chemical binding]; other site
541229004475	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
541229004476	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229004477	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
541229004478	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
541229004479	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229004480	Catalytic site [active]
541229004481	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
541229004482	Domain of unknown function (DUF4047); Region: DUF4047; pfam13256
541229004483	Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389
541229004484	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229004485	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229004486	non-specific DNA binding site [nucleotide binding]; other site
541229004487	salt bridge; other site
541229004488	sequence-specific DNA binding site [nucleotide binding]; other site
541229004489	Anti-repressor SinI; Region: SinI; pfam08671
541229004490	Anti-repressor SinI; Region: SinI; pfam08671
541229004491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
541229004492	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
541229004493	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
541229004494	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
541229004495	NAD(P) binding site [chemical binding]; other site
541229004496	catalytic residues [active]
541229004497	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
541229004498	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
541229004499	Walker A/P-loop; other site
541229004500	ATP binding site [chemical binding]; other site
541229004501	Q-loop/lid; other site
541229004502	ABC transporter signature motif; other site
541229004503	Walker B; other site
541229004504	D-loop; other site
541229004505	H-loop/switch region; other site
541229004506	TOBE domain; Region: TOBE_2; pfam08402
541229004507	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
541229004508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004509	dimer interface [polypeptide binding]; other site
541229004510	conserved gate region; other site
541229004511	putative PBP binding loops; other site
541229004512	ABC-ATPase subunit interface; other site
541229004513	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
541229004514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004515	dimer interface [polypeptide binding]; other site
541229004516	conserved gate region; other site
541229004517	putative PBP binding loops; other site
541229004518	ABC-ATPase subunit interface; other site
541229004519	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
541229004520	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
541229004521	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
541229004522	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
541229004523	active site
541229004524	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
541229004525	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
541229004526	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
541229004527	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
541229004528	active site
541229004529	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
541229004530	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
541229004531	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
541229004532	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
541229004533	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
541229004534	Cysteine-rich domain; Region: CCG; pfam02754
541229004535	Cysteine-rich domain; Region: CCG; pfam02754
541229004536	FAD binding domain; Region: FAD_binding_4; pfam01565
541229004537	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
541229004538	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
541229004539	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
541229004540	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
541229004541	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
541229004542	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
541229004543	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229004544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229004545	active site
541229004546	phosphorylation site [posttranslational modification]
541229004547	intermolecular recognition site; other site
541229004548	dimerization interface [polypeptide binding]; other site
541229004549	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229004550	DNA binding site [nucleotide binding]
541229004551	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
541229004552	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229004553	dimerization interface [polypeptide binding]; other site
541229004554	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229004555	dimer interface [polypeptide binding]; other site
541229004556	phosphorylation site [posttranslational modification]
541229004557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229004558	ATP binding site [chemical binding]; other site
541229004559	Mg2+ binding site [ion binding]; other site
541229004560	G-X-G motif; other site
541229004561	Transcriptional regulators [Transcription]; Region: FadR; COG2186
541229004562	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229004563	DNA-binding site [nucleotide binding]; DNA binding site
541229004564	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
541229004565	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
541229004566	Cysteine-rich domain; Region: CCG; pfam02754
541229004567	Cysteine-rich domain; Region: CCG; pfam02754
541229004568	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
541229004569	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
541229004570	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
541229004571	Uncharacterized conserved protein [Function unknown]; Region: COG1556
541229004572	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
541229004573	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
541229004574	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
541229004575	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
541229004576	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
541229004577	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
541229004578	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
541229004579	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
541229004580	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
541229004581	dimer interaction site [polypeptide binding]; other site
541229004582	substrate-binding tunnel; other site
541229004583	active site
541229004584	catalytic site [active]
541229004585	substrate binding site [chemical binding]; other site
541229004586	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
541229004587	poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719
541229004588	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229004589	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
541229004590	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
541229004591	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
541229004592	NAD(P) binding site [chemical binding]; other site
541229004593	homotetramer interface [polypeptide binding]; other site
541229004594	homodimer interface [polypeptide binding]; other site
541229004595	active site
541229004596	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
541229004597	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
541229004598	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
541229004599	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
541229004600	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
541229004601	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
541229004602	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
541229004603	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
541229004604	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
541229004605	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
541229004606	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
541229004607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229004608	Walker A/P-loop; other site
541229004609	ATP binding site [chemical binding]; other site
541229004610	Q-loop/lid; other site
541229004611	ABC transporter signature motif; other site
541229004612	Walker B; other site
541229004613	D-loop; other site
541229004614	H-loop/switch region; other site
541229004615	TOBE domain; Region: TOBE_2; pfam08402
541229004616	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
541229004617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004618	dimer interface [polypeptide binding]; other site
541229004619	conserved gate region; other site
541229004620	putative PBP binding loops; other site
541229004621	ABC-ATPase subunit interface; other site
541229004622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229004623	dimer interface [polypeptide binding]; other site
541229004624	conserved gate region; other site
541229004625	putative PBP binding loops; other site
541229004626	ABC-ATPase subunit interface; other site
541229004627	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
541229004628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229004629	motif II; other site
541229004630	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
541229004631	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229004632	catalytic residue [active]
541229004633	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
541229004634	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
541229004635	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
541229004636	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
541229004637	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229004638	heme-binding site [chemical binding]; other site
541229004639	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004640	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
541229004641	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004642	Leucine-rich repeats; other site
541229004643	Substrate binding site [chemical binding]; other site
541229004644	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004645	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004646	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004647	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004648	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004649	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
541229004650	LRR adjacent; Region: LRR_adjacent; pfam08191
541229004651	S-layer homology domain; Region: SLH; pfam00395
541229004652	S-layer homology domain; Region: SLH; pfam00395
541229004653	S-layer homology domain; Region: SLH; pfam00395
541229004654	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
541229004655	intersubunit interface [polypeptide binding]; other site
541229004656	active site
541229004657	Zn2+ binding site [ion binding]; other site
541229004658	FOG: CBS domain [General function prediction only]; Region: COG0517
541229004659	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
541229004660	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
541229004661	NodB motif; other site
541229004662	putative active site [active]
541229004663	putative catalytic site [active]
541229004664	Zn binding site [ion binding]; other site
541229004665	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
541229004666	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
541229004667	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229004668	dimer interface [polypeptide binding]; other site
541229004669	phosphorylation site [posttranslational modification]
541229004670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229004671	ATP binding site [chemical binding]; other site
541229004672	Mg2+ binding site [ion binding]; other site
541229004673	G-X-G motif; other site
541229004674	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229004675	MarR family; Region: MarR; pfam01047
541229004676	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
541229004677	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
541229004678	active site
541229004679	Zn binding site [ion binding]; other site
541229004680	DinB superfamily; Region: DinB_2; pfam12867
541229004681	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
541229004682	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229004683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229004684	dimer interface [polypeptide binding]; other site
541229004685	phosphorylation site [posttranslational modification]
541229004686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229004687	ATP binding site [chemical binding]; other site
541229004688	Mg2+ binding site [ion binding]; other site
541229004689	G-X-G motif; other site
541229004690	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
541229004691	Ligand Binding Site [chemical binding]; other site
541229004692	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
541229004693	active site
541229004694	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
541229004695	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
541229004696	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
541229004697	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953
541229004698	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
541229004699	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229004700	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229004701	Coenzyme A binding pocket [chemical binding]; other site
541229004702	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
541229004703	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
541229004704	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
541229004705	Class I ribonucleotide reductase; Region: RNR_I; cd01679
541229004706	active site
541229004707	dimer interface [polypeptide binding]; other site
541229004708	catalytic residues [active]
541229004709	effector binding site; other site
541229004710	R2 peptide binding site; other site
541229004711	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
541229004712	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
541229004713	dimer interface [polypeptide binding]; other site
541229004714	putative radical transfer pathway; other site
541229004715	diiron center [ion binding]; other site
541229004716	tyrosyl radical; other site
541229004717	Predicted transcriptional regulators [Transcription]; Region: COG1725
541229004718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229004719	DNA-binding site [nucleotide binding]; DNA binding site
541229004720	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229004721	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229004722	Walker A/P-loop; other site
541229004723	ATP binding site [chemical binding]; other site
541229004724	Q-loop/lid; other site
541229004725	ABC transporter signature motif; other site
541229004726	Walker B; other site
541229004727	D-loop; other site
541229004728	H-loop/switch region; other site
541229004729	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229004730	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229004731	Walker A/P-loop; other site
541229004732	ATP binding site [chemical binding]; other site
541229004733	Q-loop/lid; other site
541229004734	ABC transporter signature motif; other site
541229004735	Walker B; other site
541229004736	D-loop; other site
541229004737	H-loop/switch region; other site
541229004738	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
541229004739	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
541229004740	CAAX protease self-immunity; Region: Abi; pfam02517
541229004741	Protein of unknown function (DUF3913); Region: DUF3913; pfam13052
541229004742	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
541229004743	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229004744	putative DNA binding site [nucleotide binding]; other site
541229004745	putative Zn2+ binding site [ion binding]; other site
541229004746	AsnC family; Region: AsnC_trans_reg; pfam01037
541229004747	Uncharacterized conserved protein [Function unknown]; Region: COG2128
541229004748	Isochorismatase family; Region: Isochorismatase; pfam00857
541229004749	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
541229004750	catalytic triad [active]
541229004751	conserved cis-peptide bond; other site
541229004752	SseB protein; Region: SseB; cl06279
541229004753	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
541229004754	dimer interface [polypeptide binding]; other site
541229004755	catalytic triad [active]
541229004756	Nitronate monooxygenase; Region: NMO; pfam03060
541229004757	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
541229004758	FMN binding site [chemical binding]; other site
541229004759	substrate binding site [chemical binding]; other site
541229004760	putative catalytic residue [active]
541229004761	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
541229004762	DltD N-terminal region; Region: DltD_N; pfam04915
541229004763	DltD central region; Region: DltD_M; pfam04918
541229004764	DltD C-terminal region; Region: DltD_C; pfam04914
541229004765	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
541229004766	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
541229004767	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
541229004768	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
541229004769	acyl-activating enzyme (AAE) consensus motif; other site
541229004770	AMP binding site [chemical binding]; other site
541229004771	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
541229004772	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
541229004773	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
541229004774	metal binding site [ion binding]; metal-binding site
541229004775	dimer interface [polypeptide binding]; other site
541229004776	flavodoxin; Provisional; Region: PRK06756
541229004777	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
541229004778	Phosphotransferase enzyme family; Region: APH; pfam01636
541229004779	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229004780	active site
541229004781	substrate binding site [chemical binding]; other site
541229004782	ATP binding site [chemical binding]; other site
541229004783	multidrug efflux protein; Reviewed; Region: PRK01766
541229004784	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
541229004785	cation binding site [ion binding]; other site
541229004786	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
541229004787	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
541229004788	Regulatory protein YrvL; Region: YrvL; pfam14184
541229004789	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229004790	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
541229004791	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
541229004792	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
541229004793	Cation transport protein; Region: TrkH; pfam02386
541229004794	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
541229004795	hypothetical protein; Provisional; Region: PRK03094
541229004796	Protein of unknown function (DUF3911); Region: DUF3911; pfam13050
541229004797	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
541229004798	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
541229004799	homodimer interface [polypeptide binding]; other site
541229004800	substrate-cofactor binding pocket; other site
541229004801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229004802	catalytic residue [active]
541229004803	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
541229004804	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
541229004805	PYR/PP interface [polypeptide binding]; other site
541229004806	dimer interface [polypeptide binding]; other site
541229004807	TPP binding site [chemical binding]; other site
541229004808	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
541229004809	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
541229004810	TPP-binding site [chemical binding]; other site
541229004811	dimer interface [polypeptide binding]; other site
541229004812	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
541229004813	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
541229004814	putative valine binding site [chemical binding]; other site
541229004815	dimer interface [polypeptide binding]; other site
541229004816	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
541229004817	ketol-acid reductoisomerase; Provisional; Region: PRK05479
541229004818	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
541229004819	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
541229004820	2-isopropylmalate synthase; Validated; Region: PRK00915
541229004821	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
541229004822	active site
541229004823	catalytic residues [active]
541229004824	metal binding site [ion binding]; metal-binding site
541229004825	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
541229004826	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
541229004827	tartrate dehydrogenase; Region: TTC; TIGR02089
541229004828	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
541229004829	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
541229004830	substrate binding site [chemical binding]; other site
541229004831	ligand binding site [chemical binding]; other site
541229004832	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
541229004833	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
541229004834	substrate binding site [chemical binding]; other site
541229004835	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
541229004836	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
541229004837	dimer interface [polypeptide binding]; other site
541229004838	motif 1; other site
541229004839	active site
541229004840	motif 2; other site
541229004841	motif 3; other site
541229004842	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
541229004843	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
541229004844	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
541229004845	histidinol dehydrogenase; Region: hisD; TIGR00069
541229004846	NAD binding site [chemical binding]; other site
541229004847	dimerization interface [polypeptide binding]; other site
541229004848	product binding site; other site
541229004849	substrate binding site [chemical binding]; other site
541229004850	zinc binding site [ion binding]; other site
541229004851	catalytic residues [active]
541229004852	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
541229004853	putative active site pocket [active]
541229004854	4-fold oligomerization interface [polypeptide binding]; other site
541229004855	metal binding residues [ion binding]; metal-binding site
541229004856	3-fold/trimer interface [polypeptide binding]; other site
541229004857	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
541229004858	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
541229004859	putative active site [active]
541229004860	oxyanion strand; other site
541229004861	catalytic triad [active]
541229004862	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
541229004863	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
541229004864	catalytic residues [active]
541229004865	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
541229004866	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
541229004867	substrate binding site [chemical binding]; other site
541229004868	glutamase interaction surface [polypeptide binding]; other site
541229004869	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
541229004870	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
541229004871	metal binding site [ion binding]; metal-binding site
541229004872	histidinol-phosphatase; Validated; Region: PRK06740
541229004873	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
541229004874	dimer interface [polypeptide binding]; other site
541229004875	active site
541229004876	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
541229004877	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
541229004878	putative ligand binding site [chemical binding]; other site
541229004879	putative NAD binding site [chemical binding]; other site
541229004880	catalytic site [active]
541229004881	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
541229004882	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
541229004883	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
541229004884	Sulfatase; Region: Sulfatase; pfam00884
541229004885	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
541229004886	diaminopimelate decarboxylase; Region: lysA; TIGR01048
541229004887	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
541229004888	active site
541229004889	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
541229004890	substrate binding site [chemical binding]; other site
541229004891	catalytic residues [active]
541229004892	dimer interface [polypeptide binding]; other site
541229004893	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
541229004894	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
541229004895	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
541229004896	Active Sites [active]
541229004897	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
541229004898	ATP-sulfurylase; Region: ATPS; cd00517
541229004899	active site
541229004900	HXXH motif; other site
541229004901	flexible loop; other site
541229004902	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
541229004903	AAA domain; Region: AAA_18; pfam13238
541229004904	ligand-binding site [chemical binding]; other site
541229004905	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
541229004906	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
541229004907	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
541229004908	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
541229004909	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
541229004910	diphthine synthase; Region: dph5; TIGR00522
541229004911	active site
541229004912	SAM binding site [chemical binding]; other site
541229004913	homodimer interface [polypeptide binding]; other site
541229004914	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
541229004915	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
541229004916	putative active site [active]
541229004917	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
541229004918	putative active site [active]
541229004919	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
541229004920	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
541229004921	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
541229004922	Na2 binding site [ion binding]; other site
541229004923	putative substrate binding site 1 [chemical binding]; other site
541229004924	Na binding site 1 [ion binding]; other site
541229004925	putative substrate binding site 2 [chemical binding]; other site
541229004926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
541229004927	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229004928	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229004929	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
541229004930	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
541229004931	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
541229004932	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
541229004933	Vpu protein; Region: Vpu; pfam00558
541229004934	PspA/IM30 family; Region: PspA_IM30; pfam04012
541229004935	potential frameshift: common BLAST hit: gi|376265378|ref|YP_005118090.1| Transporter LiaF
541229004936	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
541229004937	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229004938	Histidine kinase; Region: HisKA_3; pfam07730
541229004939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229004940	ATP binding site [chemical binding]; other site
541229004941	Mg2+ binding site [ion binding]; other site
541229004942	G-X-G motif; other site
541229004943	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229004944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229004945	active site
541229004946	phosphorylation site [posttranslational modification]
541229004947	intermolecular recognition site; other site
541229004948	dimerization interface [polypeptide binding]; other site
541229004949	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229004950	DNA binding residues [nucleotide binding]
541229004951	dimerization interface [polypeptide binding]; other site
541229004952	Protein of unknown function (DUF3992); Region: DUF3922; pfam13059
541229004953	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
541229004954	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229004955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229004956	S-adenosylmethionine binding site [chemical binding]; other site
541229004957	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
541229004958	Peptidase family M50; Region: Peptidase_M50; pfam02163
541229004959	active site
541229004960	putative substrate binding region [chemical binding]; other site
541229004961	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
541229004962	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
541229004963	heme-binding site [chemical binding]; other site
541229004964	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
541229004965	FAD binding pocket [chemical binding]; other site
541229004966	FAD binding motif [chemical binding]; other site
541229004967	phosphate binding motif [ion binding]; other site
541229004968	beta-alpha-beta structure motif; other site
541229004969	NAD binding pocket [chemical binding]; other site
541229004970	Heme binding  pocket [chemical binding]; other site
541229004971	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
541229004972	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
541229004973	ligand binding site [chemical binding]; other site
541229004974	flexible hinge region; other site
541229004975	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
541229004976	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229004977	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
541229004978	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
541229004979	Transglycosylase; Region: Transgly; pfam00912
541229004980	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
541229004981	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229004982	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
541229004983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
541229004984	putative active site [active]
541229004985	heme pocket [chemical binding]; other site
541229004986	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229004987	dimer interface [polypeptide binding]; other site
541229004988	phosphorylation site [posttranslational modification]
541229004989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229004990	ATP binding site [chemical binding]; other site
541229004991	Mg2+ binding site [ion binding]; other site
541229004992	G-X-G motif; other site
541229004993	Protein of unknown function DUF72; Region: DUF72; pfam01904
541229004994	Protein of unknown function (DUF3924); Region: DUF3924; pfam13062
541229004995	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
541229004996	active site
541229004997	DNA binding site [nucleotide binding]
541229004998	Int/Topo IB signature motif; other site
541229004999	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229005000	dimerization interface [polypeptide binding]; other site
541229005001	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229005002	dimer interface [polypeptide binding]; other site
541229005003	phosphorylation site [posttranslational modification]
541229005004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229005005	ATP binding site [chemical binding]; other site
541229005006	Mg2+ binding site [ion binding]; other site
541229005007	G-X-G motif; other site
541229005008	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
541229005009	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
541229005010	Predicted integral membrane protein [Function unknown]; Region: COG0392
541229005011	Uncharacterized conserved protein [Function unknown]; Region: COG2898
541229005012	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
541229005013	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
541229005014	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
541229005015	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
541229005016	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
541229005017	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
541229005018	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229005019	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
541229005020	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
541229005021	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
541229005022	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
541229005023	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229005024	RNA binding surface [nucleotide binding]; other site
541229005025	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
541229005026	active site
541229005027	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
541229005028	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
541229005029	catalytic residues [active]
541229005030	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
541229005031	ResB-like family; Region: ResB; pfam05140
541229005032	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
541229005033	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
541229005034	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229005035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229005036	active site
541229005037	phosphorylation site [posttranslational modification]
541229005038	intermolecular recognition site; other site
541229005039	dimerization interface [polypeptide binding]; other site
541229005040	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229005041	DNA binding site [nucleotide binding]
541229005042	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
541229005043	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229005044	dimerization interface [polypeptide binding]; other site
541229005045	PAS domain; Region: PAS; smart00091
541229005046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229005047	dimer interface [polypeptide binding]; other site
541229005048	phosphorylation site [posttranslational modification]
541229005049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229005050	ATP binding site [chemical binding]; other site
541229005051	Mg2+ binding site [ion binding]; other site
541229005052	G-X-G motif; other site
541229005053	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
541229005054	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229005055	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229005056	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
541229005057	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229005058	Predicted membrane protein [Function unknown]; Region: COG3601
541229005059	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
541229005060	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
541229005061	DEAD-like helicases superfamily; Region: DEXDc; smart00487
541229005062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229005063	ATP binding site [chemical binding]; other site
541229005064	putative Mg++ binding site [ion binding]; other site
541229005065	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229005066	nucleotide binding region [chemical binding]; other site
541229005067	ATP-binding site [chemical binding]; other site
541229005068	CAAX protease self-immunity; Region: Abi; pfam02517
541229005069	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229005070	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
541229005071	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229005072	putative active site [active]
541229005073	putative metal binding site [ion binding]; other site
541229005074	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229005075	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
541229005076	DNA binding residues [nucleotide binding]
541229005077	B12 binding domain; Region: B12-binding_2; pfam02607
541229005078	adaptor protein; Provisional; Region: PRK02899
541229005079	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
541229005080	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
541229005081	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
541229005082	NAD(P) binding site [chemical binding]; other site
541229005083	Domain of unknown function (DUF3961); Region: DUF3961; pfam13106
541229005084	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229005085	amidase catalytic site [active]
541229005086	Zn binding residues [ion binding]; other site
541229005087	substrate binding site [chemical binding]; other site
541229005088	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
541229005089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
541229005090	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229005091	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
541229005092	active site
541229005093	homodimer interface [polypeptide binding]; other site
541229005094	homotetramer interface [polypeptide binding]; other site
541229005095	cytidylate kinase; Provisional; Region: cmk; PRK00023
541229005096	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
541229005097	CMP-binding site; other site
541229005098	The sites determining sugar specificity; other site
541229005099	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
541229005100	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
541229005101	RNA binding site [nucleotide binding]; other site
541229005102	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
541229005103	RNA binding site [nucleotide binding]; other site
541229005104	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
541229005105	RNA binding site [nucleotide binding]; other site
541229005106	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
541229005107	RNA binding site [nucleotide binding]; other site
541229005108	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
541229005109	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
541229005110	homotetramer interface [polypeptide binding]; other site
541229005111	FMN binding site [chemical binding]; other site
541229005112	homodimer contacts [polypeptide binding]; other site
541229005113	putative active site [active]
541229005114	putative substrate binding site [chemical binding]; other site
541229005115	YpzI-like protein; Region: YpzI; pfam14140
541229005116	YIEGIA protein; Region: YIEGIA; pfam14045
541229005117	GTP-binding protein Der; Reviewed; Region: PRK00093
541229005118	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
541229005119	G1 box; other site
541229005120	GTP/Mg2+ binding site [chemical binding]; other site
541229005121	Switch I region; other site
541229005122	G2 box; other site
541229005123	Switch II region; other site
541229005124	G3 box; other site
541229005125	G4 box; other site
541229005126	G5 box; other site
541229005127	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
541229005128	G1 box; other site
541229005129	GTP/Mg2+ binding site [chemical binding]; other site
541229005130	Switch I region; other site
541229005131	G2 box; other site
541229005132	G3 box; other site
541229005133	Switch II region; other site
541229005134	G4 box; other site
541229005135	G5 box; other site
541229005136	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
541229005137	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
541229005138	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
541229005139	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
541229005140	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
541229005141	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
541229005142	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
541229005143	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
541229005144	IHF dimer interface [polypeptide binding]; other site
541229005145	IHF - DNA interface [nucleotide binding]; other site
541229005146	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
541229005147	homodecamer interface [polypeptide binding]; other site
541229005148	GTP cyclohydrolase I; Provisional; Region: PLN03044
541229005149	active site
541229005150	putative catalytic site residues [active]
541229005151	zinc binding site [ion binding]; other site
541229005152	GTP-CH-I/GFRP interaction surface; other site
541229005153	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
541229005154	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
541229005155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229005156	S-adenosylmethionine binding site [chemical binding]; other site
541229005157	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
541229005158	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
541229005159	substrate binding pocket [chemical binding]; other site
541229005160	chain length determination region; other site
541229005161	substrate-Mg2+ binding site; other site
541229005162	catalytic residues [active]
541229005163	aspartate-rich region 1; other site
541229005164	active site lid residues [active]
541229005165	aspartate-rich region 2; other site
541229005166	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
541229005167	active site
541229005168	multimer interface [polypeptide binding]; other site
541229005169	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
541229005170	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
541229005171	Tetramer interface [polypeptide binding]; other site
541229005172	active site
541229005173	FMN-binding site [chemical binding]; other site
541229005174	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
541229005175	active site
541229005176	dimer interface [polypeptide binding]; other site
541229005177	metal binding site [ion binding]; metal-binding site
541229005178	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
541229005179	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229005180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229005181	homodimer interface [polypeptide binding]; other site
541229005182	catalytic residue [active]
541229005183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229005184	binding surface
541229005185	TPR motif; other site
541229005186	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
541229005187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229005188	binding surface
541229005189	TPR motif; other site
541229005190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229005191	binding surface
541229005192	TPR motif; other site
541229005193	hypothetical protein; Provisional; Region: PRK03636
541229005194	UPF0302 domain; Region: UPF0302; pfam08864
541229005195	IDEAL domain; Region: IDEAL; pfam08858
541229005196	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
541229005197	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
541229005198	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
541229005199	iron-sulfur cluster [ion binding]; other site
541229005200	[2Fe-2S] cluster binding site [ion binding]; other site
541229005201	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
541229005202	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
541229005203	interchain domain interface [polypeptide binding]; other site
541229005204	intrachain domain interface; other site
541229005205	heme bH binding site [chemical binding]; other site
541229005206	Qi binding site; other site
541229005207	heme bL binding site [chemical binding]; other site
541229005208	Qo binding site; other site
541229005209	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
541229005210	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
541229005211	interchain domain interface [polypeptide binding]; other site
541229005212	intrachain domain interface; other site
541229005213	Qi binding site; other site
541229005214	Qo binding site; other site
541229005215	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
541229005216	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
541229005217	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
541229005218	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
541229005219	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577
541229005220	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
541229005221	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
541229005222	active site
541229005223	Fe-S cluster binding site [ion binding]; other site
541229005224	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229005225	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229005226	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229005227	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229005228	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
541229005229	homodimer interface [polypeptide binding]; other site
541229005230	metal binding site [ion binding]; metal-binding site
541229005231	dihydrodipicolinate reductase; Provisional; Region: PRK00048
541229005232	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
541229005233	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
541229005234	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
541229005235	active site
541229005236	dimer interfaces [polypeptide binding]; other site
541229005237	catalytic residues [active]
541229005238	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
541229005239	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
541229005240	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
541229005241	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
541229005242	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
541229005243	active site
541229005244	NTP binding site [chemical binding]; other site
541229005245	metal binding triad [ion binding]; metal-binding site
541229005246	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
541229005247	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
541229005248	Biotin operon repressor [Transcription]; Region: BirA; COG1654
541229005249	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
541229005250	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
541229005251	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
541229005252	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
541229005253	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
541229005254	oligomerization interface [polypeptide binding]; other site
541229005255	active site
541229005256	metal binding site [ion binding]; metal-binding site
541229005257	pantoate--beta-alanine ligase; Region: panC; TIGR00018
541229005258	Pantoate-beta-alanine ligase; Region: PanC; cd00560
541229005259	active site
541229005260	ATP-binding site [chemical binding]; other site
541229005261	pantoate-binding site; other site
541229005262	HXXH motif; other site
541229005263	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
541229005264	tetramerization interface [polypeptide binding]; other site
541229005265	active site
541229005266	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
541229005267	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
541229005268	active site
541229005269	catalytic site [active]
541229005270	substrate binding site [chemical binding]; other site
541229005271	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
541229005272	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
541229005273	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
541229005274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
541229005275	aspartate aminotransferase; Provisional; Region: PRK05764
541229005276	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229005277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229005278	homodimer interface [polypeptide binding]; other site
541229005279	catalytic residue [active]
541229005280	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
541229005281	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
541229005282	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229005283	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
541229005284	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
541229005285	minor groove reading motif; other site
541229005286	helix-hairpin-helix signature motif; other site
541229005287	substrate binding pocket [chemical binding]; other site
541229005288	active site
541229005289	Transglycosylase; Region: Transgly; pfam00912
541229005290	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
541229005291	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229005292	Fibronectin type III domain; Region: fn3; pfam00041
541229005293	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
541229005294	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
541229005295	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
541229005296	YppF-like protein; Region: YppF; pfam14178
541229005297	YppG-like protein; Region: YppG; pfam14179
541229005298	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
541229005299	hypothetical protein; Provisional; Region: PRK13660
541229005300	cell division protein GpsB; Provisional; Region: PRK14127
541229005301	DivIVA domain; Region: DivI1A_domain; TIGR03544
541229005302	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
541229005303	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
541229005304	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
541229005305	Protein of unknown function (DUF3921); Region: DUF3921; pfam13060
541229005306	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
541229005307	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
541229005308	active site
541229005309	Zn binding site [ion binding]; other site
541229005310	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229005311	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229005312	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
541229005313	active site
541229005314	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229005315	active site
541229005316	xanthine permease; Region: pbuX; TIGR03173
541229005317	Predicted membrane protein [Function unknown]; Region: COG2311
541229005318	Protein of unknown function (DUF418); Region: DUF418; cl12135
541229005319	Protein of unknown function (DUF418); Region: DUF418; pfam04235
541229005320	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
541229005321	Dynamin family; Region: Dynamin_N; pfam00350
541229005322	G1 box; other site
541229005323	GTP/Mg2+ binding site [chemical binding]; other site
541229005324	G2 box; other site
541229005325	Switch I region; other site
541229005326	G3 box; other site
541229005327	Switch II region; other site
541229005328	G4 box; other site
541229005329	G5 box; other site
541229005330	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
541229005331	Dynamin family; Region: Dynamin_N; pfam00350
541229005332	G1 box; other site
541229005333	GTP/Mg2+ binding site [chemical binding]; other site
541229005334	G2 box; other site
541229005335	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
541229005336	G3 box; other site
541229005337	Switch II region; other site
541229005338	GTP/Mg2+ binding site [chemical binding]; other site
541229005339	G4 box; other site
541229005340	G5 box; other site
541229005341	Protein of unknown function (DUF3931); Region: DUF3931; pfam13082
541229005342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229005343	Coenzyme A binding pocket [chemical binding]; other site
541229005344	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
541229005345	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
541229005346	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
541229005347	active site residue [active]
541229005348	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
541229005349	active site residue [active]
541229005350	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
541229005351	Predicted membrane protein [Function unknown]; Region: COG3766
541229005352	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
541229005353	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
541229005354	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229005355	5'-3' exonuclease; Region: 53EXOc; smart00475
541229005356	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
541229005357	active site
541229005358	metal binding site 1 [ion binding]; metal-binding site
541229005359	putative 5' ssDNA interaction site; other site
541229005360	metal binding site 3; metal-binding site
541229005361	metal binding site 2 [ion binding]; metal-binding site
541229005362	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
541229005363	putative DNA binding site [nucleotide binding]; other site
541229005364	putative metal binding site [ion binding]; other site
541229005365	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
541229005366	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
541229005367	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
541229005368	Chain length determinant protein; Region: Wzz; cl15801
541229005369	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
541229005370	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
541229005371	Bacterial sugar transferase; Region: Bac_transf; pfam02397
541229005372	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
541229005373	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
541229005374	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
541229005375	O-Antigen ligase; Region: Wzy_C; pfam04932
541229005376	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229005377	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
541229005378	active site
541229005379	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
541229005380	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229005381	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
541229005382	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005383	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005384	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005385	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005386	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005387	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005388	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005389	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005390	Domain of unknown function DUF11; Region: DUF11; cl17728
541229005391	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005392	Domain of unknown function DUF11; Region: DUF11; cl17728
541229005393	Domain of unknown function DUF11; Region: DUF11; cl17728
541229005394	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005395	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005396	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005397	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005398	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005399	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005400	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005401	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005402	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005403	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005404	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005405	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005406	Domain of unknown function DUF11; Region: DUF11; cl17728
541229005407	Domain of unknown function DUF11; Region: DUF11; cl17728
541229005408	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005409	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229005410	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
541229005411	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
541229005412	Isochorismatase family; Region: Isochorismatase; pfam00857
541229005413	catalytic triad [active]
541229005414	conserved cis-peptide bond; other site
541229005415	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229005416	EamA-like transporter family; Region: EamA; pfam00892
541229005417	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
541229005418	RNA/DNA hybrid binding site [nucleotide binding]; other site
541229005419	active site
541229005420	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
541229005421	active site
541229005422	catalytic residues [active]
541229005423	QueT transporter; Region: QueT; pfam06177
541229005424	hypothetical protein; Validated; Region: PRK07708
541229005425	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
541229005426	RNA/DNA hybrid binding site [nucleotide binding]; other site
541229005427	active site
541229005428	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
541229005429	Protein of unknown function (DUF2564); Region: DUF2564; pfam10819
541229005430	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
541229005431	DNA-binding site [nucleotide binding]; DNA binding site
541229005432	RNA-binding motif; other site
541229005433	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
541229005434	LysE type translocator; Region: LysE; pfam01810
541229005435	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
541229005436	Protein of unknown function, DUF485; Region: DUF485; pfam04341
541229005437	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
541229005438	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
541229005439	Na binding site [ion binding]; other site
541229005440	aminotransferase; Validated; Region: PRK07678
541229005441	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229005442	inhibitor-cofactor binding pocket; inhibition site
541229005443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229005444	catalytic residue [active]
541229005445	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
541229005446	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
541229005447	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
541229005448	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
541229005449	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
541229005450	DNA binding residues [nucleotide binding]
541229005451	drug binding residues [chemical binding]; other site
541229005452	dimer interface [polypeptide binding]; other site
541229005453	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
541229005454	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
541229005455	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
541229005456	Predicted membrane protein [Function unknown]; Region: COG2323
541229005457	Uncharacterized conserved protein [Function unknown]; Region: COG1434
541229005458	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
541229005459	putative active site [active]
541229005460	Tic20-like protein; Region: Tic20; pfam09685
541229005461	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
541229005462	dimer interface [polypeptide binding]; other site
541229005463	FMN binding site [chemical binding]; other site
541229005464	NADPH bind site [chemical binding]; other site
541229005465	RNA polymerase factor sigma-70; Validated; Region: PRK06811
541229005466	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229005467	DNA binding residues [nucleotide binding]
541229005468	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229005469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005470	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229005471	putative substrate translocation pore; other site
541229005472	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229005473	dimerization interface [polypeptide binding]; other site
541229005474	putative DNA binding site [nucleotide binding]; other site
541229005475	putative Zn2+ binding site [ion binding]; other site
541229005476	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229005477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005478	putative substrate translocation pore; other site
541229005479	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229005480	active site
541229005481	metal binding site [ion binding]; metal-binding site
541229005482	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229005483	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
541229005484	bacterial Hfq-like; Region: Hfq; cd01716
541229005485	hexamer interface [polypeptide binding]; other site
541229005486	Sm1 motif; other site
541229005487	RNA binding site [nucleotide binding]; other site
541229005488	Sm2 motif; other site
541229005489	HD domain; Region: HD_3; pfam13023
541229005490	flagellar motor switch protein; Reviewed; Region: PRK06782
541229005491	CheC-like family; Region: CheC; pfam04509
541229005492	CheC-like family; Region: CheC; pfam04509
541229005493	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
541229005494	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
541229005495	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
541229005496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229005497	Protein of unknown function (DUF327); Region: DUF327; pfam03885
541229005498	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
541229005499	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
541229005500	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
541229005501	flagellar capping protein; Validated; Region: fliD; PRK06798
541229005502	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
541229005503	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
541229005504	Flagellar protein FliS; Region: FliS; cl00654
541229005505	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
541229005506	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
541229005507	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
541229005508	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
541229005509	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
541229005510	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
541229005511	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
541229005512	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
541229005513	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
541229005514	FliG C-terminal domain; Region: FliG_C; pfam01706
541229005515	flagellar assembly protein H; Validated; Region: fliH; PRK06800
541229005516	Flagellar assembly protein FliH; Region: FliH; pfam02108
541229005517	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
541229005518	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229005519	Walker A motif; other site
541229005520	ATP binding site [chemical binding]; other site
541229005521	Walker B motif; other site
541229005522	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
541229005523	flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792
541229005524	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
541229005525	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
541229005526	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
541229005527	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
541229005528	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
541229005529	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
541229005530	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
541229005531	Response regulator receiver domain; Region: Response_reg; pfam00072
541229005532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229005533	active site
541229005534	phosphorylation site [posttranslational modification]
541229005535	intermolecular recognition site; other site
541229005536	dimerization interface [polypeptide binding]; other site
541229005537	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
541229005538	flagellin; Provisional; Region: PRK12807
541229005539	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
541229005540	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
541229005541	flagellin; Reviewed; Region: PRK08869
541229005542	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
541229005543	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
541229005544	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
541229005545	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
541229005546	N-acetyl-D-glucosamine binding site [chemical binding]; other site
541229005547	catalytic residue [active]
541229005548	flagellar motor switch protein; Validated; Region: PRK06789
541229005549	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
541229005550	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
541229005551	flagellar motor switch protein; Validated; Region: PRK06788
541229005552	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
541229005553	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
541229005554	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
541229005555	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
541229005556	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
541229005557	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
541229005558	FHIPEP family; Region: FHIPEP; pfam00771
541229005559	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889
541229005560	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
541229005561	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
541229005562	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
541229005563	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
541229005564	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
541229005565	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
541229005566	active site
541229005567	non-prolyl cis peptide bond; other site
541229005568	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
541229005569	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
541229005570	Predicted transcriptional regulators [Transcription]; Region: COG1378
541229005571	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
541229005572	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
541229005573	C-terminal domain interface [polypeptide binding]; other site
541229005574	sugar binding site [chemical binding]; other site
541229005575	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
541229005576	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
541229005577	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
541229005578	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
541229005579	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
541229005580	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
541229005581	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
541229005582	DXD motif; other site
541229005583	PilZ domain; Region: PilZ; pfam07238
541229005584	PilZ domain; Region: PilZ; pfam07238
541229005585	small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861
541229005586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229005587	non-specific DNA binding site [nucleotide binding]; other site
541229005588	salt bridge; other site
541229005589	sequence-specific DNA binding site [nucleotide binding]; other site
541229005590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005591	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229005592	putative substrate translocation pore; other site
541229005593	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
541229005594	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
541229005595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229005596	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229005597	dimerization interface [polypeptide binding]; other site
541229005598	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
541229005599	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229005600	Walker A/P-loop; other site
541229005601	ATP binding site [chemical binding]; other site
541229005602	Q-loop/lid; other site
541229005603	ABC transporter signature motif; other site
541229005604	Walker B; other site
541229005605	D-loop; other site
541229005606	H-loop/switch region; other site
541229005607	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
541229005608	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
541229005609	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
541229005610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229005611	dimer interface [polypeptide binding]; other site
541229005612	conserved gate region; other site
541229005613	putative PBP binding loops; other site
541229005614	ABC-ATPase subunit interface; other site
541229005615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229005616	dimer interface [polypeptide binding]; other site
541229005617	conserved gate region; other site
541229005618	putative PBP binding loops; other site
541229005619	ABC-ATPase subunit interface; other site
541229005620	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
541229005621	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
541229005622	Beta-Casp domain; Region: Beta-Casp; smart01027
541229005623	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
541229005624	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229005625	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229005626	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
541229005627	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
541229005628	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
541229005629	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229005630	catalytic core [active]
541229005631	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
541229005632	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229005633	hypothetical protein; Provisional; Region: PRK09272
541229005634	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229005635	dimerization interface [polypeptide binding]; other site
541229005636	putative Zn2+ binding site [ion binding]; other site
541229005637	putative DNA binding site [nucleotide binding]; other site
541229005638	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
541229005639	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
541229005640	active site
541229005641	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
541229005642	dimer interface [polypeptide binding]; other site
541229005643	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
541229005644	Ligand Binding Site [chemical binding]; other site
541229005645	Molecular Tunnel; other site
541229005646	RNA polymerase factor sigma-70; Validated; Region: PRK06811
541229005647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229005648	DNA binding residues [nucleotide binding]
541229005649	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
541229005650	VPS10 domain; Region: VPS10; smart00602
541229005651	VPS10 domain; Region: VPS10; smart00602
541229005652	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
541229005653	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
541229005654	Protein of unknown function (DUF3940); Region: DUF3940; pfam13076
541229005655	Transcriptional regulators [Transcription]; Region: GntR; COG1802
541229005656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229005657	DNA-binding site [nucleotide binding]; DNA binding site
541229005658	FCD domain; Region: FCD; pfam07729
541229005659	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229005660	EamA-like transporter family; Region: EamA; pfam00892
541229005661	EamA-like transporter family; Region: EamA; pfam00892
541229005662	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
541229005663	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
541229005664	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
541229005665	Predicted permeases [General function prediction only]; Region: COG0701
541229005666	TIGR03943 family protein; Region: TIGR03943
541229005667	Methyltransferase domain; Region: Methyltransf_24; pfam13578
541229005668	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
541229005669	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
541229005670	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
541229005671	DNA binding residues [nucleotide binding]
541229005672	putative dimer interface [polypeptide binding]; other site
541229005673	short chain dehydrogenase; Provisional; Region: PRK06123
541229005674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229005675	NAD(P) binding site [chemical binding]; other site
541229005676	active site
541229005677	fumarate hydratase; Reviewed; Region: fumC; PRK00485
541229005678	Class II fumarases; Region: Fumarase_classII; cd01362
541229005679	active site
541229005680	tetramer interface [polypeptide binding]; other site
541229005681	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
541229005682	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
541229005683	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
541229005684	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
541229005685	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
541229005686	active site pocket [active]
541229005687	oxyanion hole [active]
541229005688	catalytic triad [active]
541229005689	active site nucleophile [active]
541229005690	Protein of unknown function (DUF3942); Region: DUF3942; pfam13078
541229005691	Penicillinase repressor; Region: Pencillinase_R; pfam03965
541229005692	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
541229005693	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
541229005694	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
541229005695	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
541229005696	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
541229005697	catalytic residues [active]
541229005698	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
541229005699	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229005700	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
541229005701	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229005702	non-specific DNA binding site [nucleotide binding]; other site
541229005703	salt bridge; other site
541229005704	sequence-specific DNA binding site [nucleotide binding]; other site
541229005705	Cupin domain; Region: Cupin_2; pfam07883
541229005706	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
541229005707	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
541229005708	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229005709	catalytic residue [active]
541229005710	Protein of unknown function (DUF445); Region: DUF445; pfam04286
541229005711	Pleckstrin homology-like domain; Region: PH-like; cl17171
541229005712	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
541229005713	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229005714	DNA binding residues [nucleotide binding]
541229005715	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229005716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229005717	active site
541229005718	phosphorylation site [posttranslational modification]
541229005719	intermolecular recognition site; other site
541229005720	dimerization interface [polypeptide binding]; other site
541229005721	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229005722	DNA binding residues [nucleotide binding]
541229005723	dimerization interface [polypeptide binding]; other site
541229005724	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229005725	Histidine kinase; Region: HisKA_3; pfam07730
541229005726	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229005727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229005728	Walker A/P-loop; other site
541229005729	ATP binding site [chemical binding]; other site
541229005730	Q-loop/lid; other site
541229005731	ABC transporter signature motif; other site
541229005732	Walker B; other site
541229005733	D-loop; other site
541229005734	H-loop/switch region; other site
541229005735	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
541229005736	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
541229005737	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
541229005738	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
541229005739	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
541229005740	putative active site [active]
541229005741	catalytic site [active]
541229005742	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
541229005743	PLD-like domain; Region: PLDc_2; pfam13091
541229005744	putative active site [active]
541229005745	catalytic site [active]
541229005746	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
541229005747	putative nucleotide binding site [chemical binding]; other site
541229005748	uridine monophosphate binding site [chemical binding]; other site
541229005749	homohexameric interface [polypeptide binding]; other site
541229005750	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
541229005751	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
541229005752	aspartate ammonia-lyase; Provisional; Region: PRK14515
541229005753	Aspartase; Region: Aspartase; cd01357
541229005754	active sites [active]
541229005755	tetramer interface [polypeptide binding]; other site
541229005756	malate dehydrogenase; Provisional; Region: PRK13529
541229005757	Malic enzyme, N-terminal domain; Region: malic; pfam00390
541229005758	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
541229005759	NAD(P) binding site [chemical binding]; other site
541229005760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229005761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229005762	ATP binding site [chemical binding]; other site
541229005763	Mg2+ binding site [ion binding]; other site
541229005764	G-X-G motif; other site
541229005765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229005766	Response regulator receiver domain; Region: Response_reg; pfam00072
541229005767	active site
541229005768	phosphorylation site [posttranslational modification]
541229005769	intermolecular recognition site; other site
541229005770	dimerization interface [polypeptide binding]; other site
541229005771	YcbB domain; Region: YcbB; pfam08664
541229005772	SWIM zinc finger; Region: SWIM; pfam04434
541229005773	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
541229005774	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
541229005775	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229005776	ATP binding site [chemical binding]; other site
541229005777	putative Mg++ binding site [ion binding]; other site
541229005778	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229005779	nucleotide binding region [chemical binding]; other site
541229005780	ATP-binding site [chemical binding]; other site
541229005781	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
541229005782	dimer interface [polypeptide binding]; other site
541229005783	active site
541229005784	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229005785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229005786	non-specific DNA binding site [nucleotide binding]; other site
541229005787	salt bridge; other site
541229005788	sequence-specific DNA binding site [nucleotide binding]; other site
541229005789	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229005790	aspartate kinase; Reviewed; Region: PRK06635
541229005791	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
541229005792	putative nucleotide binding site [chemical binding]; other site
541229005793	putative catalytic residues [active]
541229005794	putative Mg ion binding site [ion binding]; other site
541229005795	putative aspartate binding site [chemical binding]; other site
541229005796	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
541229005797	putative allosteric regulatory site; other site
541229005798	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
541229005799	putative allosteric regulatory residue; other site
541229005800	DoxX-like family; Region: DoxX_3; pfam13781
541229005801	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
541229005802	YndJ-like protein; Region: YndJ; pfam14158
541229005803	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
541229005804	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229005805	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229005806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005807	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229005808	putative substrate translocation pore; other site
541229005809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005810	putative substrate translocation pore; other site
541229005811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005812	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229005813	putative substrate translocation pore; other site
541229005814	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
541229005815	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
541229005816	dimer interface [polypeptide binding]; other site
541229005817	active site
541229005818	CoA binding pocket [chemical binding]; other site
541229005819	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
541229005820	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
541229005821	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
541229005822	HflX GTPase family; Region: HflX; cd01878
541229005823	G1 box; other site
541229005824	GTP/Mg2+ binding site [chemical binding]; other site
541229005825	Switch I region; other site
541229005826	G2 box; other site
541229005827	G3 box; other site
541229005828	Switch II region; other site
541229005829	G4 box; other site
541229005830	G5 box; other site
541229005831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005832	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229005833	putative substrate translocation pore; other site
541229005834	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
541229005835	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
541229005836	dimer interface [polypeptide binding]; other site
541229005837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229005838	catalytic residue [active]
541229005839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229005840	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
541229005841	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
541229005842	Na2 binding site [ion binding]; other site
541229005843	putative substrate binding site 1 [chemical binding]; other site
541229005844	Na binding site 1 [ion binding]; other site
541229005845	putative substrate binding site 2 [chemical binding]; other site
541229005846	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229005847	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
541229005848	NodB motif; other site
541229005849	putative active site [active]
541229005850	putative catalytic site [active]
541229005851	putative Zn binding site [ion binding]; other site
541229005852	Mor transcription activator family; Region: Mor; cl02360
541229005853	Predicted membrane protein [Function unknown]; Region: COG2323
541229005854	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
541229005855	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
541229005856	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
541229005857	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
541229005858	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
541229005859	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
541229005860	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
541229005861	methionine sulfoxide reductase A; Provisional; Region: PRK14054
541229005862	short chain dehydrogenase; Provisional; Region: PRK12747
541229005863	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
541229005864	NADP binding site [chemical binding]; other site
541229005865	homodimer interface [polypeptide binding]; other site
541229005866	active site
541229005867	substrate binding site [chemical binding]; other site
541229005868	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
541229005869	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
541229005870	homodimer interface [polypeptide binding]; other site
541229005871	substrate-cofactor binding pocket; other site
541229005872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229005873	catalytic residue [active]
541229005874	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725
541229005875	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
541229005876	PYR/PP interface [polypeptide binding]; other site
541229005877	dimer interface [polypeptide binding]; other site
541229005878	TPP binding site [chemical binding]; other site
541229005879	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
541229005880	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
541229005881	TPP-binding site [chemical binding]; other site
541229005882	dimer interface [polypeptide binding]; other site
541229005883	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
541229005884	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
541229005885	putative valine binding site [chemical binding]; other site
541229005886	dimer interface [polypeptide binding]; other site
541229005887	ketol-acid reductoisomerase; Provisional; Region: PRK05479
541229005888	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
541229005889	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
541229005890	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
541229005891	threonine dehydratase; Validated; Region: PRK08639
541229005892	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
541229005893	tetramer interface [polypeptide binding]; other site
541229005894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229005895	catalytic residue [active]
541229005896	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
541229005897	putative Ile/Val binding site [chemical binding]; other site
541229005898	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
541229005899	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
541229005900	putative active site [active]
541229005901	putative metal binding site [ion binding]; other site
541229005902	Protein of unknown function (DUF554); Region: DUF554; pfam04474
541229005903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229005904	Coenzyme A binding pocket [chemical binding]; other site
541229005905	drug efflux system protein MdtG; Provisional; Region: PRK09874
541229005906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229005907	putative substrate translocation pore; other site
541229005908	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
541229005909	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
541229005910	putative active site [active]
541229005911	metal binding site [ion binding]; metal-binding site
541229005912	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
541229005913	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229005914	LytTr DNA-binding domain; Region: LytTR; pfam04397
541229005915	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
541229005916	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
541229005917	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
541229005918	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
541229005919	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229005920	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229005921	Coenzyme A binding pocket [chemical binding]; other site
541229005922	5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493
541229005923	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
541229005924	active site
541229005925	putative substrate binding pocket [chemical binding]; other site
541229005926	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229005927	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229005928	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229005929	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229005930	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229005931	peptide binding site [polypeptide binding]; other site
541229005932	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229005933	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229005934	Coenzyme A binding pocket [chemical binding]; other site
541229005935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229005936	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229005937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229005938	active site
541229005939	phosphorylation site [posttranslational modification]
541229005940	intermolecular recognition site; other site
541229005941	dimerization interface [polypeptide binding]; other site
541229005942	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229005943	DNA binding site [nucleotide binding]
541229005944	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229005945	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229005946	dimerization interface [polypeptide binding]; other site
541229005947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229005948	dimer interface [polypeptide binding]; other site
541229005949	phosphorylation site [posttranslational modification]
541229005950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229005951	ATP binding site [chemical binding]; other site
541229005952	Mg2+ binding site [ion binding]; other site
541229005953	G-X-G motif; other site
541229005954	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229005955	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229005956	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229005957	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
541229005958	manganese transport protein MntH; Reviewed; Region: PRK00701
541229005959	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
541229005960	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
541229005961	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
541229005962	active site residue [active]
541229005963	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
541229005964	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
541229005965	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
541229005966	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
541229005967	Amino acid permease; Region: AA_permease_2; pfam13520
541229005968	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229005969	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229005970	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229005971	Peptidase M60-like family; Region: M60-like; pfam13402
541229005972	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
541229005973	sugar binding site [chemical binding]; other site
541229005974	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
541229005975	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
541229005976	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229005977	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229005978	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229005979	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229005980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229005981	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229005982	Coenzyme A binding pocket [chemical binding]; other site
541229005983	hypothetical protein; Provisional; Region: PRK12856
541229005984	CAAX protease self-immunity; Region: Abi; pfam02517
541229005985	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229005986	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229005987	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
541229005988	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229005989	DNA binding residues [nucleotide binding]
541229005990	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
541229005991	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
541229005992	intersubunit interface [polypeptide binding]; other site
541229005993	active site
541229005994	catalytic residue [active]
541229005995	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229005996	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229005997	Nucleoside recognition; Region: Gate; pfam07670
541229005998	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229005999	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
541229006000	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
541229006001	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
541229006002	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
541229006003	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
541229006004	active site
541229006005	catalytic motif [active]
541229006006	Zn binding site [ion binding]; other site
541229006007	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
541229006008	hypothetical protein; Provisional; Region: PRK01631
541229006009	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
541229006010	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229006011	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229006012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229006013	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229006014	dimerization interface [polypeptide binding]; other site
541229006015	Family description; Region: DsbD_2; pfam13386
541229006016	proline aminopeptidase P II; Provisional; Region: PRK10879
541229006017	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
541229006018	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
541229006019	active site
541229006020	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
541229006021	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
541229006022	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
541229006023	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
541229006024	Multicopper oxidase; Region: Cu-oxidase; pfam00394
541229006025	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
541229006026	DNA topoisomerase III; Provisional; Region: PRK07726
541229006027	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
541229006028	active site
541229006029	putative interdomain interaction site [polypeptide binding]; other site
541229006030	putative metal-binding site [ion binding]; other site
541229006031	putative nucleotide binding site [chemical binding]; other site
541229006032	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
541229006033	domain I; other site
541229006034	DNA binding groove [nucleotide binding]
541229006035	phosphate binding site [ion binding]; other site
541229006036	domain II; other site
541229006037	domain III; other site
541229006038	nucleotide binding site [chemical binding]; other site
541229006039	catalytic site [active]
541229006040	domain IV; other site
541229006041	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
541229006042	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
541229006043	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
541229006044	Sodium Bile acid symporter family; Region: SBF; cl17470
541229006045	azoreductase; Provisional; Region: PRK13555
541229006046	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
541229006047	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229006048	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
541229006049	dimer interface [polypeptide binding]; other site
541229006050	substrate binding site [chemical binding]; other site
541229006051	metal binding site [ion binding]; metal-binding site
541229006052	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
541229006053	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
541229006054	YtkA-like; Region: YtkA; pfam13115
541229006055	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
541229006056	EamA-like transporter family; Region: EamA; pfam00892
541229006057	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229006058	EamA-like transporter family; Region: EamA; pfam00892
541229006059	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229006060	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229006061	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229006062	dimerization interface [polypeptide binding]; other site
541229006063	Predicted transcriptional regulator [Transcription]; Region: COG1959
541229006064	Transcriptional regulator; Region: Rrf2; pfam02082
541229006065	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
541229006066	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
541229006067	catalytic residues [active]
541229006068	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
541229006069	dimer interface [polypeptide binding]; other site
541229006070	FMN binding site [chemical binding]; other site
541229006071	Amidase; Region: Amidase; cl11426
541229006072	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229006073	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229006074	non-specific DNA binding site [nucleotide binding]; other site
541229006075	salt bridge; other site
541229006076	sequence-specific DNA binding site [nucleotide binding]; other site
541229006077	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229006078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229006079	non-specific DNA binding site [nucleotide binding]; other site
541229006080	salt bridge; other site
541229006081	sequence-specific DNA binding site [nucleotide binding]; other site
541229006082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229006083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229006084	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229006085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229006086	AAA domain; Region: AAA_23; pfam13476
541229006087	Walker A/P-loop; other site
541229006088	ATP binding site [chemical binding]; other site
541229006089	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229006090	Walker B; other site
541229006091	D-loop; other site
541229006092	H-loop/switch region; other site
541229006093	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
541229006094	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229006095	active site
541229006096	metal binding site [ion binding]; metal-binding site
541229006097	DNA binding site [nucleotide binding]
541229006098	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
541229006099	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229006100	ATP binding site [chemical binding]; other site
541229006101	putative Mg++ binding site [ion binding]; other site
541229006102	helicase superfamily c-terminal domain; Region: HELICc; smart00490
541229006103	ATP-binding site [chemical binding]; other site
541229006104	Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896
541229006105	nucleotide binding site [chemical binding]; other site
541229006106	Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241
541229006107	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
541229006108	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
541229006109	active site
541229006110	substrate binding site [chemical binding]; other site
541229006111	catalytic site [active]
541229006112	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
541229006113	active site
541229006114	DNA binding site [nucleotide binding]
541229006115	catalytic site [active]
541229006116	dUTPase; Region: dUTPase_2; pfam08761
541229006117	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
541229006118	active site
541229006119	homodimer interface [polypeptide binding]; other site
541229006120	metal binding site [ion binding]; metal-binding site
541229006121	'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl15779
541229006122	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
541229006123	DNA methylase; Region: N6_N4_Mtase; pfam01555
541229006124	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564
541229006125	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229006126	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229006127	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
541229006128	catalytic residues [active]
541229006129	catalytic nucleophile [active]
541229006130	Presynaptic Site I dimer interface [polypeptide binding]; other site
541229006131	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
541229006132	Synaptic Flat tetramer interface [polypeptide binding]; other site
541229006133	Synaptic Site I dimer interface [polypeptide binding]; other site
541229006134	DNA binding site [nucleotide binding]
541229006135	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
541229006136	DNA-binding interface [nucleotide binding]; DNA binding site
541229006137	Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022
541229006138	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
541229006139	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
541229006140	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
541229006141	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
541229006142	Head fiber protein; Region: Phage_head_fibr; pfam11133
541229006143	phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126
541229006144	Phage protein; Region: DUF3647; pfam12363
541229006145	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
541229006146	Phage-related protein [Function unknown]; Region: COG5412
541229006147	Phage tail protein; Region: Sipho_tail; pfam05709
541229006148	Phage tail protein; Region: Sipho_tail; cl17486
541229006149	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
541229006150	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
541229006151	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
541229006152	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229006153	active site
541229006154	catalytic residues [active]
541229006155	DNA binding site [nucleotide binding]
541229006156	Int/Topo IB signature motif; other site
541229006157	Holin family; Region: Phage_holin_4; pfam05105
541229006158	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
541229006159	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
541229006160	active site
541229006161	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
541229006162	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
541229006163	non-specific DNA binding site [nucleotide binding]; other site
541229006164	sequence-specific DNA binding site [nucleotide binding]; other site
541229006165	salt bridge; other site
541229006166	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229006167	Replication-relaxation; Region: Replic_Relax; pfam13814
541229006168	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229006169	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
541229006170	catalytic residues [active]
541229006171	catalytic nucleophile [active]
541229006172	Recombinase; Region: Recombinase; pfam07508
541229006173	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229006174	Recombinase; Region: Recombinase; pfam07508
541229006175	Amidase; Region: Amidase; cl11426
541229006176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
541229006177	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
541229006178	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
541229006179	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
541229006180	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
541229006181	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
541229006182	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229006183	NAD binding site [chemical binding]; other site
541229006184	dimer interface [polypeptide binding]; other site
541229006185	substrate binding site [chemical binding]; other site
541229006186	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
541229006187	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229006188	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
541229006189	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
541229006190	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
541229006191	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
541229006192	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
541229006193	putative ligand binding site [chemical binding]; other site
541229006194	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
541229006195	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
541229006196	Walker A/P-loop; other site
541229006197	ATP binding site [chemical binding]; other site
541229006198	Q-loop/lid; other site
541229006199	ABC transporter signature motif; other site
541229006200	Walker B; other site
541229006201	D-loop; other site
541229006202	H-loop/switch region; other site
541229006203	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
541229006204	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
541229006205	Walker A/P-loop; other site
541229006206	ATP binding site [chemical binding]; other site
541229006207	Q-loop/lid; other site
541229006208	ABC transporter signature motif; other site
541229006209	Walker B; other site
541229006210	D-loop; other site
541229006211	H-loop/switch region; other site
541229006212	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
541229006213	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
541229006214	TM-ABC transporter signature motif; other site
541229006215	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
541229006216	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
541229006217	TM-ABC transporter signature motif; other site
541229006218	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229006219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229006220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
541229006221	dimerization interface [polypeptide binding]; other site
541229006222	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
541229006223	active site 1 [active]
541229006224	dimer interface [polypeptide binding]; other site
541229006225	hexamer interface [polypeptide binding]; other site
541229006226	active site 2 [active]
541229006227	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
541229006228	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229006229	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229006230	putative Zn2+ binding site [ion binding]; other site
541229006231	putative DNA binding site [nucleotide binding]; other site
541229006232	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
541229006233	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
541229006234	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
541229006235	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
541229006236	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
541229006237	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
541229006238	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
541229006239	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229006240	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
541229006241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229006242	Walker A/P-loop; other site
541229006243	ATP binding site [chemical binding]; other site
541229006244	Q-loop/lid; other site
541229006245	ABC transporter signature motif; other site
541229006246	Walker B; other site
541229006247	D-loop; other site
541229006248	H-loop/switch region; other site
541229006249	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
541229006250	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229006251	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
541229006252	Walker A/P-loop; other site
541229006253	ATP binding site [chemical binding]; other site
541229006254	Q-loop/lid; other site
541229006255	ABC transporter signature motif; other site
541229006256	Walker B; other site
541229006257	D-loop; other site
541229006258	H-loop/switch region; other site
541229006259	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
541229006260	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229006261	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
541229006262	active site
541229006263	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229006264	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229006265	active site
541229006266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229006267	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229006268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
541229006269	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
541229006270	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
541229006271	inhibitor-cofactor binding pocket; inhibition site
541229006272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229006273	catalytic residue [active]
541229006274	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
541229006275	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
541229006276	trimer interface [polypeptide binding]; other site
541229006277	active site
541229006278	substrate binding site [chemical binding]; other site
541229006279	CoA binding site [chemical binding]; other site
541229006280	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
541229006281	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
541229006282	putative dimer interface [polypeptide binding]; other site
541229006283	catalytic triad [active]
541229006284	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229006285	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
541229006286	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
541229006287	dimer interface [polypeptide binding]; other site
541229006288	FMN binding site [chemical binding]; other site
541229006289	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229006290	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229006291	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229006292	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229006293	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229006294	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
541229006295	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229006296	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229006297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229006298	Walker A/P-loop; other site
541229006299	ATP binding site [chemical binding]; other site
541229006300	Q-loop/lid; other site
541229006301	ABC transporter signature motif; other site
541229006302	Walker B; other site
541229006303	D-loop; other site
541229006304	H-loop/switch region; other site
541229006305	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229006306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229006307	active site
541229006308	phosphorylation site [posttranslational modification]
541229006309	intermolecular recognition site; other site
541229006310	dimerization interface [polypeptide binding]; other site
541229006311	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229006312	DNA binding site [nucleotide binding]
541229006313	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229006314	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229006315	dimerization interface [polypeptide binding]; other site
541229006316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229006317	dimer interface [polypeptide binding]; other site
541229006318	phosphorylation site [posttranslational modification]
541229006319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229006320	ATP binding site [chemical binding]; other site
541229006321	Mg2+ binding site [ion binding]; other site
541229006322	G-X-G motif; other site
541229006323	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
541229006324	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
541229006325	classical (c) SDRs; Region: SDR_c; cd05233
541229006326	NAD(P) binding site [chemical binding]; other site
541229006327	active site
541229006328	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
541229006329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229006330	S-adenosylmethionine binding site [chemical binding]; other site
541229006331	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
541229006332	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229006333	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
541229006334	NodB motif; other site
541229006335	active site
541229006336	catalytic site [active]
541229006337	metal binding site [ion binding]; metal-binding site
541229006338	SdpI/YhfL protein family; Region: SdpI; pfam13630
541229006339	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692
541229006340	nudix motif; other site
541229006341	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
541229006342	homoserine dehydrogenase; Provisional; Region: PRK06349
541229006343	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
541229006344	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
541229006345	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
541229006346	threonine synthase; Reviewed; Region: PRK06721
541229006347	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
541229006348	homodimer interface [polypeptide binding]; other site
541229006349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229006350	catalytic residue [active]
541229006351	homoserine kinase; Provisional; Region: PRK01212
541229006352	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
541229006353	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
541229006354	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
541229006355	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
541229006356	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229006357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229006358	active site
541229006359	phosphorylation site [posttranslational modification]
541229006360	intermolecular recognition site; other site
541229006361	dimerization interface [polypeptide binding]; other site
541229006362	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229006363	DNA binding site [nucleotide binding]
541229006364	HAMP domain; Region: HAMP; pfam00672
541229006365	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229006366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229006367	dimer interface [polypeptide binding]; other site
541229006368	phosphorylation site [posttranslational modification]
541229006369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229006370	ATP binding site [chemical binding]; other site
541229006371	Mg2+ binding site [ion binding]; other site
541229006372	G-X-G motif; other site
541229006373	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229006374	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
541229006375	NodB motif; other site
541229006376	active site
541229006377	catalytic site [active]
541229006378	Zn binding site [ion binding]; other site
541229006379	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
541229006380	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
541229006381	MgtC family; Region: MgtC; pfam02308
541229006382	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
541229006383	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006384	Coenzyme A binding pocket [chemical binding]; other site
541229006385	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
541229006386	IucA / IucC family; Region: IucA_IucC; pfam04183
541229006387	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
541229006388	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
541229006389	IucA / IucC family; Region: IucA_IucC; pfam04183
541229006390	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
541229006391	acyl-CoA synthetase; Validated; Region: PRK08308
541229006392	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
541229006393	acyl-activating enzyme (AAE) consensus motif; other site
541229006394	AMP binding site [chemical binding]; other site
541229006395	active site
541229006396	CoA binding site [chemical binding]; other site
541229006397	acyl carrier protein; Provisional; Region: PRK07639
541229006398	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
541229006399	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
541229006400	Metal-binding active site; metal-binding site
541229006401	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
541229006402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229006403	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229006404	putative substrate translocation pore; other site
541229006405	Lysine efflux permease [General function prediction only]; Region: COG1279
541229006406	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229006407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229006408	DNA-binding site [nucleotide binding]; DNA binding site
541229006409	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229006410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229006411	homodimer interface [polypeptide binding]; other site
541229006412	catalytic residue [active]
541229006413	Protein of unknown function (DUF3933); Region: DUF3933; pfam13069
541229006414	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
541229006415	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
541229006416	active site
541229006417	nucleophile elbow; other site
541229006418	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
541229006419	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
541229006420	Domain of unknown function (DUF4083); Region: DUF4083; pfam13314
541229006421	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
541229006422	nudix motif; other site
541229006423	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
541229006424	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
541229006425	homodimer interface [polypeptide binding]; other site
541229006426	NAD binding pocket [chemical binding]; other site
541229006427	ATP binding pocket [chemical binding]; other site
541229006428	Mg binding site [ion binding]; other site
541229006429	active-site loop [active]
541229006430	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
541229006431	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229006432	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
541229006433	active site
541229006434	catalytic residues [active]
541229006435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229006436	dimerization interface [polypeptide binding]; other site
541229006437	putative DNA binding site [nucleotide binding]; other site
541229006438	putative Zn2+ binding site [ion binding]; other site
541229006439	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229006440	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229006441	active site
541229006442	catalytic tetrad [active]
541229006443	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229006444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229006445	putative substrate translocation pore; other site
541229006446	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
541229006447	Protein of unknown function (DUF664); Region: DUF664; pfam04978
541229006448	DinB superfamily; Region: DinB_2; pfam12867
541229006449	GTPase RsgA; Reviewed; Region: PRK01889
541229006450	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
541229006451	RNA binding site [nucleotide binding]; other site
541229006452	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
541229006453	GTPase/Zn-binding domain interface [polypeptide binding]; other site
541229006454	GTP/Mg2+ binding site [chemical binding]; other site
541229006455	G4 box; other site
541229006456	G5 box; other site
541229006457	G1 box; other site
541229006458	Switch I region; other site
541229006459	G2 box; other site
541229006460	G3 box; other site
541229006461	Switch II region; other site
541229006462	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
541229006463	Cache domain; Region: Cache_1; pfam02743
541229006464	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229006465	dimerization interface [polypeptide binding]; other site
541229006466	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229006467	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229006468	dimer interface [polypeptide binding]; other site
541229006469	putative CheW interface [polypeptide binding]; other site
541229006470	Protein of unknown function (DUF3979); Region: DUF3979; pfam13141
541229006471	Uncharacterized membrane protein [Function unknown]; Region: COG3949
541229006472	Ferritin-like domain; Region: Ferritin; pfam00210
541229006473	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
541229006474	dimerization interface [polypeptide binding]; other site
541229006475	DPS ferroxidase diiron center [ion binding]; other site
541229006476	ion pore; other site
541229006477	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
541229006478	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
541229006479	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
541229006480	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
541229006481	Protein of unknown function (DUF3896); Region: DUF3896; pfam13035
541229006482	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
541229006483	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229006484	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229006485	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229006486	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229006487	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229006488	active site
541229006489	catalytic tetrad [active]
541229006490	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
541229006491	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
541229006492	P-loop, Walker A motif; other site
541229006493	Base recognition motif; other site
541229006494	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
541229006495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229006496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006497	Coenzyme A binding pocket [chemical binding]; other site
541229006498	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
541229006499	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
541229006500	metal binding site [ion binding]; metal-binding site
541229006501	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
541229006502	NADH(P)-binding; Region: NAD_binding_10; pfam13460
541229006503	NAD binding site [chemical binding]; other site
541229006504	active site
541229006505	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
541229006506	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
541229006507	active site
541229006508	FMN binding site [chemical binding]; other site
541229006509	substrate binding site [chemical binding]; other site
541229006510	homotetramer interface [polypeptide binding]; other site
541229006511	catalytic residue [active]
541229006512	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
541229006513	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
541229006514	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229006515	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229006516	peptide binding site [polypeptide binding]; other site
541229006517	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
541229006518	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229006519	active site
541229006520	metal binding site [ion binding]; metal-binding site
541229006521	short chain dehydrogenase; Provisional; Region: PRK08309
541229006522	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229006523	catalytic core [active]
541229006524	CotH protein; Region: CotH; pfam08757
541229006525	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
541229006526	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
541229006527	nudix motif; other site
541229006528	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229006529	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229006530	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
541229006531	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
541229006532	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
541229006533	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
541229006534	Cl binding site [ion binding]; other site
541229006535	oligomer interface [polypeptide binding]; other site
541229006536	Predicted permeases [General function prediction only]; Region: COG0701
541229006537	Predicted membrane protein [Function unknown]; Region: COG3689
541229006538	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
541229006539	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
541229006540	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
541229006541	putative active site [active]
541229006542	catalytic site [active]
541229006543	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
541229006544	putative active site [active]
541229006545	catalytic site [active]
541229006546	Coat F domain; Region: Coat_F; pfam07875
541229006547	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
541229006548	NADH(P)-binding; Region: NAD_binding_10; pfam13460
541229006549	NAD binding site [chemical binding]; other site
541229006550	substrate binding site [chemical binding]; other site
541229006551	putative active site [active]
541229006552	Protein of unknown function (DUF456); Region: DUF456; pfam04306
541229006553	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
541229006554	Domain of unknown function DUF21; Region: DUF21; pfam01595
541229006555	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
541229006556	Transporter associated domain; Region: CorC_HlyC; smart01091
541229006557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229006558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229006559	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
541229006560	FOG: CBS domain [General function prediction only]; Region: COG0517
541229006561	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
541229006562	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
541229006563	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
541229006564	dimer interface [polypeptide binding]; other site
541229006565	putative tRNA-binding site [nucleotide binding]; other site
541229006566	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
541229006567	DinB superfamily; Region: DinB_2; pfam12867
541229006568	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
541229006569	stage II sporulation protein P; Region: spore_II_P; TIGR02867
541229006570	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229006571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006572	Coenzyme A binding pocket [chemical binding]; other site
541229006573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229006574	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
541229006575	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
541229006576	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
541229006577	nudix motif; other site
541229006578	amidase; Provisional; Region: PRK06828
541229006579	Amidase; Region: Amidase; pfam01425
541229006580	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229006581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229006582	putative substrate translocation pore; other site
541229006583	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
541229006584	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
541229006585	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
541229006586	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
541229006587	stage II sporulation protein P; Region: spore_II_P; TIGR02867
541229006588	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229006589	catalytic core [active]
541229006590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229006591	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229006592	active site
541229006593	motif I; other site
541229006594	motif II; other site
541229006595	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229006596	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229006597	MarR family; Region: MarR; pfam01047
541229006598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229006599	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229006600	putative substrate translocation pore; other site
541229006601	DinB superfamily; Region: DinB_2; pfam12867
541229006602	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
541229006603	alanine racemase; Reviewed; Region: alr; PRK00053
541229006604	active site
541229006605	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
541229006606	dimer interface [polypeptide binding]; other site
541229006607	substrate binding site [chemical binding]; other site
541229006608	catalytic residues [active]
541229006609	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229006610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229006611	S-adenosylmethionine binding site [chemical binding]; other site
541229006612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006613	Coenzyme A binding pocket [chemical binding]; other site
541229006614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006615	Coenzyme A binding pocket [chemical binding]; other site
541229006616	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229006617	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
541229006618	glycosyltransferase, MGT family; Region: MGT; TIGR01426
541229006619	active site
541229006620	TDP-binding site; other site
541229006621	acceptor substrate-binding pocket; other site
541229006622	homodimer interface [polypeptide binding]; other site
541229006623	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229006624	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229006625	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229006626	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229006627	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229006628	DNA-binding site [nucleotide binding]; DNA binding site
541229006629	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229006630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229006631	homodimer interface [polypeptide binding]; other site
541229006632	catalytic residue [active]
541229006633	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006634	Coenzyme A binding pocket [chemical binding]; other site
541229006635	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229006636	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
541229006637	active site
541229006638	metal binding site [ion binding]; metal-binding site
541229006639	Src Homology 3 domain superfamily; Region: SH3; cl17036
541229006640	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229006641	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006642	Coenzyme A binding pocket [chemical binding]; other site
541229006643	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
541229006644	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229006645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006646	Coenzyme A binding pocket [chemical binding]; other site
541229006647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006648	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229006649	Coenzyme A binding pocket [chemical binding]; other site
541229006650	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
541229006651	Predicted acetyltransferase [General function prediction only]; Region: COG3393
541229006652	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006653	Coenzyme A binding pocket [chemical binding]; other site
541229006654	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
541229006655	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229006656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229006657	S-adenosylmethionine binding site [chemical binding]; other site
541229006658	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
541229006659	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
541229006660	Potassium binding sites [ion binding]; other site
541229006661	Cesium cation binding sites [ion binding]; other site
541229006662	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
541229006663	DEAD-like helicases superfamily; Region: DEXDc; smart00487
541229006664	ATP binding site [chemical binding]; other site
541229006665	putative Mg++ binding site [ion binding]; other site
541229006666	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229006667	nucleotide binding region [chemical binding]; other site
541229006668	ATP-binding site [chemical binding]; other site
541229006669	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
541229006670	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229006671	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
541229006672	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229006673	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
541229006674	NADP binding site [chemical binding]; other site
541229006675	dimer interface [polypeptide binding]; other site
541229006676	RNA polymerase sigma factor; Provisional; Region: PRK12543
541229006677	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229006678	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229006679	DNA binding residues [nucleotide binding]
541229006680	Domain of unknown function (DUF3600); Region: DUF3600; pfam12207
541229006681	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
541229006682	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229006683	Protein of unknown function (DUF3925); Region: DUF3925; pfam13063
541229006684	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
541229006685	catalytic residues [active]
541229006686	dimer interface [polypeptide binding]; other site
541229006687	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
541229006688	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
541229006689	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
541229006690	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
541229006691	Protein of unknown function DUF58; Region: DUF58; pfam01882
541229006692	MoxR-like ATPases [General function prediction only]; Region: COG0714
541229006693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229006694	Walker A motif; other site
541229006695	ATP binding site [chemical binding]; other site
541229006696	Walker B motif; other site
541229006697	arginine finger; other site
541229006698	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
541229006699	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
541229006700	[4Fe-4S] binding site [ion binding]; other site
541229006701	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
541229006702	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
541229006703	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
541229006704	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
541229006705	molybdopterin cofactor binding site; other site
541229006706	nitrate reductase, beta subunit; Region: narH; TIGR01660
541229006707	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
541229006708	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
541229006709	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
541229006710	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
541229006711	ligand binding site [chemical binding]; other site
541229006712	flexible hinge region; other site
541229006713	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
541229006714	putative switch regulator; other site
541229006715	non-specific DNA interactions [nucleotide binding]; other site
541229006716	DNA binding site [nucleotide binding]
541229006717	sequence specific DNA binding site [nucleotide binding]; other site
541229006718	putative cAMP binding site [chemical binding]; other site
541229006719	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
541229006720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229006721	FeS/SAM binding site; other site
541229006722	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
541229006723	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
541229006724	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
541229006725	ATP binding site [chemical binding]; other site
541229006726	substrate interface [chemical binding]; other site
541229006727	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
541229006728	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
541229006729	dimer interface [polypeptide binding]; other site
541229006730	putative functional site; other site
541229006731	putative MPT binding site; other site
541229006732	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
541229006733	MoaE homodimer interface [polypeptide binding]; other site
541229006734	MoaD interaction [polypeptide binding]; other site
541229006735	active site residues [active]
541229006736	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
541229006737	MoaE interaction surface [polypeptide binding]; other site
541229006738	MoeB interaction surface [polypeptide binding]; other site
541229006739	thiocarboxylated glycine; other site
541229006740	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
541229006741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229006742	putative substrate translocation pore; other site
541229006743	Predicted permeases [General function prediction only]; Region: COG0679
541229006744	precorrin-2 dehydrogenase; Validated; Region: PRK06719
541229006745	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
541229006746	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
541229006747	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
541229006748	putative active site [active]
541229006749	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
541229006750	putative active site [active]
541229006751	bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168
541229006752	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
541229006753	active site
541229006754	SAM binding site [chemical binding]; other site
541229006755	homodimer interface [polypeptide binding]; other site
541229006756	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
541229006757	[2Fe-2S] cluster binding site [ion binding]; other site
541229006758	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
541229006759	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229006760	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
541229006761	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
541229006762	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
541229006763	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
541229006764	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
541229006765	Hemerythrin-like domain; Region: Hr-like; cd12108
541229006766	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
541229006767	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
541229006768	PGAP1-like protein; Region: PGAP1; pfam07819
541229006769	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
541229006770	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
541229006771	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
541229006772	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229006773	Zn2+ binding site [ion binding]; other site
541229006774	Mg2+ binding site [ion binding]; other site
541229006775	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
541229006776	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229006777	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229006778	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229006779	ABC transporter; Region: ABC_tran_2; pfam12848
541229006780	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229006781	Bax inhibitor 1 like; Region: BaxI_1; cl17691
541229006782	Domain of unknown function (DUF4318); Region: DUF4318; pfam14201
541229006783	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
541229006784	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
541229006785	dimer interface [polypeptide binding]; other site
541229006786	ssDNA binding site [nucleotide binding]; other site
541229006787	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229006788	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
541229006789	Virulence factor; Region: Virulence_fact; pfam13769
541229006790	HEAT repeats; Region: HEAT_2; pfam13646
541229006791	HEAT repeats; Region: HEAT_2; pfam13646
541229006792	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
541229006793	Protein of unknown function, DUF393; Region: DUF393; pfam04134
541229006794	Disulphide isomerase; Region: Disulph_isomer; pfam06491
541229006795	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
541229006796	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
541229006797	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
541229006798	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
541229006799	active site
541229006800	HIGH motif; other site
541229006801	KMSK motif region; other site
541229006802	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
541229006803	tRNA binding surface [nucleotide binding]; other site
541229006804	anticodon binding site; other site
541229006805	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229006806	Methyltransferase domain; Region: Methyltransf_12; pfam08242
541229006807	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
541229006808	binding surface
541229006809	TPR motif; other site
541229006810	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
541229006811	putative active site [active]
541229006812	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229006813	binding surface
541229006814	TPR motif; other site
541229006815	TPR repeat; Region: TPR_11; pfam13414
541229006816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229006817	binding surface
541229006818	TPR motif; other site
541229006819	Tetratricopeptide repeat; Region: TPR_16; pfam13432
541229006820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229006821	binding surface
541229006822	TPR motif; other site
541229006823	TPR repeat; Region: TPR_11; pfam13414
541229006824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229006825	binding surface
541229006826	TPR motif; other site
541229006827	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229006828	binding surface
541229006829	TPR motif; other site
541229006830	Tetratricopeptide repeat; Region: TPR_16; pfam13432
541229006831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229006832	binding surface
541229006833	TPR motif; other site
541229006834	Tetratricopeptide repeat; Region: TPR_9; pfam13371
541229006835	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
541229006836	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
541229006837	HIGH motif; other site
541229006838	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
541229006839	active site
541229006840	KMSKS motif; other site
541229006841	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
541229006842	tRNA binding surface [nucleotide binding]; other site
541229006843	anticodon binding site; other site
541229006844	Protein of unknown function (DUF418); Region: DUF418; cl12135
541229006845	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229006846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229006847	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229006848	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229006849	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
541229006850	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
541229006851	Zn binding site [ion binding]; other site
541229006852	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
541229006853	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
541229006854	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
541229006855	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
541229006856	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
541229006857	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
541229006858	Dimer interface [polypeptide binding]; other site
541229006859	anticodon binding site; other site
541229006860	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
541229006861	homodimer interface [polypeptide binding]; other site
541229006862	motif 1; other site
541229006863	motif 2; other site
541229006864	active site
541229006865	motif 3; other site
541229006866	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
541229006867	metal ion-dependent adhesion site (MIDAS); other site
541229006868	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
541229006869	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229006870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229006871	Walker A motif; other site
541229006872	ATP binding site [chemical binding]; other site
541229006873	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229006874	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229006875	SseB protein; Region: SseB; cl06279
541229006876	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229006877	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
541229006878	Domain of unknown function (DUF4284); Region: DUF4284; pfam14112
541229006879	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229006880	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
541229006881	catalytic nucleophile [active]
541229006882	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229006883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229006884	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229006885	GAD-like domain; Region: GAD-like; pfam08887
541229006886	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
541229006887	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
541229006888	Na2 binding site [ion binding]; other site
541229006889	putative substrate binding site 1 [chemical binding]; other site
541229006890	Na binding site 1 [ion binding]; other site
541229006891	putative substrate binding site 2 [chemical binding]; other site
541229006892	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229006893	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
541229006894	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
541229006895	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
541229006896	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229006897	motif II; other site
541229006898	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
541229006899	fructuronate transporter; Provisional; Region: PRK10034; cl15264
541229006900	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
541229006901	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
541229006902	putative active site [active]
541229006903	metal binding site [ion binding]; metal-binding site
541229006904	aspartate racemase; Region: asp_race; TIGR00035
541229006905	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
541229006906	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
541229006907	homodimer interaction site [polypeptide binding]; other site
541229006908	cofactor binding site; other site
541229006909	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229006910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006911	Coenzyme A binding pocket [chemical binding]; other site
541229006912	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
541229006913	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229006914	salt bridge; other site
541229006915	non-specific DNA binding site [nucleotide binding]; other site
541229006916	sequence-specific DNA binding site [nucleotide binding]; other site
541229006917	hypothetical protein; Validated; Region: PRK06769
541229006918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229006919	active site
541229006920	motif I; other site
541229006921	motif II; other site
541229006922	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229006923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229006924	Coenzyme A binding pocket [chemical binding]; other site
541229006925	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229006926	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229006927	Walker A/P-loop; other site
541229006928	ATP binding site [chemical binding]; other site
541229006929	Q-loop/lid; other site
541229006930	ABC transporter signature motif; other site
541229006931	Walker B; other site
541229006932	D-loop; other site
541229006933	H-loop/switch region; other site
541229006934	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
541229006935	YpjP-like protein; Region: YpjP; pfam14005
541229006936	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
541229006937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229006938	motif II; other site
541229006939	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229006940	Phosphotransferase enzyme family; Region: APH; pfam01636
541229006941	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229006942	substrate binding site [chemical binding]; other site
541229006943	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229006944	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229006945	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
541229006946	thymidylate synthase; Region: thym_sym; TIGR03284
541229006947	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
541229006948	dimerization interface [polypeptide binding]; other site
541229006949	active site
541229006950	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
541229006951	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
541229006952	folate binding site [chemical binding]; other site
541229006953	NADP+ binding site [chemical binding]; other site
541229006954	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
541229006955	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229006956	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
541229006957	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229006958	azoreductase; Reviewed; Region: PRK00170
541229006959	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229006960	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
541229006961	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
541229006962	putative acyl-acceptor binding pocket; other site
541229006963	Haemolysin-III related; Region: HlyIII; cl03831
541229006964	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
541229006965	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
541229006966	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
541229006967	Protein of unknown function (DUF2535); Region: DUF2535; pfam10751
541229006968	EDD domain protein, DegV family; Region: DegV; TIGR00762
541229006969	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
541229006970	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
541229006971	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
541229006972	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
541229006973	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
541229006974	Cu(I) binding site [ion binding]; other site
541229006975	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
541229006976	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
541229006977	putative dimer interface [polypeptide binding]; other site
541229006978	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
541229006979	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
541229006980	active site
541229006981	dimer interface [polypeptide binding]; other site
541229006982	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
541229006983	Ligand Binding Site [chemical binding]; other site
541229006984	Molecular Tunnel; other site
541229006985	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229006986	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
541229006987	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
541229006988	active site
541229006989	metal binding site [ion binding]; metal-binding site
541229006990	Bacterial SH3 domain; Region: SH3_3; cl17532
541229006991	Bacterial SH3 domain; Region: SH3_3; cl17532
541229006992	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
541229006993	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
541229006994	siderophore binding site; other site
541229006995	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
541229006996	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
541229006997	homodimer interface [polypeptide binding]; other site
541229006998	substrate-cofactor binding pocket; other site
541229006999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229007000	catalytic residue [active]
541229007001	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
541229007002	FMN binding site [chemical binding]; other site
541229007003	dimer interface [polypeptide binding]; other site
541229007004	Isochorismatase family; Region: Isochorismatase; pfam00857
541229007005	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
541229007006	catalytic triad [active]
541229007007	conserved cis-peptide bond; other site
541229007008	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
541229007009	nudix motif; other site
541229007010	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
541229007011	Mechanosensitive ion channel; Region: MS_channel; pfam00924
541229007012	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
541229007013	GAF domain; Region: GAF; pfam01590
541229007014	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229007015	Histidine kinase; Region: HisKA_3; pfam07730
541229007016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229007017	ATP binding site [chemical binding]; other site
541229007018	Mg2+ binding site [ion binding]; other site
541229007019	G-X-G motif; other site
541229007020	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229007021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229007022	active site
541229007023	phosphorylation site [posttranslational modification]
541229007024	intermolecular recognition site; other site
541229007025	dimerization interface [polypeptide binding]; other site
541229007026	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229007027	DNA binding residues [nucleotide binding]
541229007028	dimerization interface [polypeptide binding]; other site
541229007029	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
541229007030	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
541229007031	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
541229007032	putative active site [active]
541229007033	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
541229007034	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
541229007035	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
541229007036	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
541229007037	NAD binding site [chemical binding]; other site
541229007038	substrate binding site [chemical binding]; other site
541229007039	catalytic Zn binding site [ion binding]; other site
541229007040	tetramer interface [polypeptide binding]; other site
541229007041	structural Zn binding site [ion binding]; other site
541229007042	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229007043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229007044	dimer interface [polypeptide binding]; other site
541229007045	conserved gate region; other site
541229007046	ABC-ATPase subunit interface; other site
541229007047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
541229007048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229007049	Integrase core domain; Region: rve; pfam00665
541229007050	transposase/IS protein; Provisional; Region: PRK09183
541229007051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229007052	Walker A motif; other site
541229007053	ATP binding site [chemical binding]; other site
541229007054	Walker B motif; other site
541229007055	arginine finger; other site
541229007056	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
541229007057	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
541229007058	N- and C-terminal domain interface [polypeptide binding]; other site
541229007059	active site
541229007060	catalytic site [active]
541229007061	metal binding site [ion binding]; metal-binding site
541229007062	carbohydrate binding site [chemical binding]; other site
541229007063	ATP binding site [chemical binding]; other site
541229007064	fructuronate transporter; Provisional; Region: PRK10034; cl15264
541229007065	GntP family permease; Region: GntP_permease; pfam02447
541229007066	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
541229007067	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
541229007068	Protein of unknown function (DUF2711); Region: DUF2711; pfam10924
541229007069	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229007070	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229007071	active site
541229007072	Predicted flavoprotein [General function prediction only]; Region: COG0431
541229007073	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229007074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007075	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229007076	putative substrate translocation pore; other site
541229007077	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
541229007078	Uncharacterized conserved protein [Function unknown]; Region: COG1434
541229007079	putative active site [active]
541229007080	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
541229007081	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
541229007082	Walker A/P-loop; other site
541229007083	ATP binding site [chemical binding]; other site
541229007084	Q-loop/lid; other site
541229007085	ABC transporter signature motif; other site
541229007086	Walker B; other site
541229007087	D-loop; other site
541229007088	H-loop/switch region; other site
541229007089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229007090	dimer interface [polypeptide binding]; other site
541229007091	conserved gate region; other site
541229007092	ABC-ATPase subunit interface; other site
541229007093	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
541229007094	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
541229007095	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
541229007096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
541229007097	Protein of unknown function (DUF524); Region: DUF524; pfam04411
541229007098	polar chromosome segregation protein; Reviewed; Region: racA; PRK13182
541229007099	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
541229007100	DNA binding residues [nucleotide binding]
541229007101	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
541229007102	Domain of unknown function DUF21; Region: DUF21; pfam01595
541229007103	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
541229007104	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
541229007105	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
541229007106	NAD(P) binding site [chemical binding]; other site
541229007107	catalytic residues [active]
541229007108	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
541229007109	Histidine kinase N terminal; Region: HisK_N; pfam09385
541229007110	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229007111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229007112	dimer interface [polypeptide binding]; other site
541229007113	phosphorylation site [posttranslational modification]
541229007114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229007115	ATP binding site [chemical binding]; other site
541229007116	Mg2+ binding site [ion binding]; other site
541229007117	G-X-G motif; other site
541229007118	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
541229007119	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
541229007120	hypothetical protein; Provisional; Region: PRK06917
541229007121	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229007122	inhibitor-cofactor binding pocket; inhibition site
541229007123	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229007124	catalytic residue [active]
541229007125	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
541229007126	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
541229007127	acetylornithine deacetylase; Validated; Region: PRK06915
541229007128	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
541229007129	metal binding site [ion binding]; metal-binding site
541229007130	dimer interface [polypeptide binding]; other site
541229007131	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
541229007132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229007133	Coenzyme A binding pocket [chemical binding]; other site
541229007134	PAS fold; Region: PAS_4; pfam08448
541229007135	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
541229007136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229007137	Walker A motif; other site
541229007138	ATP binding site [chemical binding]; other site
541229007139	Walker B motif; other site
541229007140	arginine finger; other site
541229007141	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
541229007142	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
541229007143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229007144	FeS/SAM binding site; other site
541229007145	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
541229007146	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
541229007147	toxin interface [polypeptide binding]; other site
541229007148	Zn binding site [ion binding]; other site
541229007149	hypothetical protein; Provisional; Region: PRK13672
541229007150	Protein of unknown function (DUF3930); Region: DUF3930; pfam13067
541229007151	YozD-like protein; Region: YozD; pfam14162
541229007152	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
541229007153	Catalytic domain of Protein Kinases; Region: PKc; cd00180
541229007154	active site
541229007155	ATP binding site [chemical binding]; other site
541229007156	substrate binding site [chemical binding]; other site
541229007157	activation loop (A-loop); other site
541229007158	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
541229007159	SpoOM protein; Region: Spo0M; pfam07070
541229007160	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
541229007161	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
541229007162	active site
541229007163	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
541229007164	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
541229007165	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229007166	catalytic residues [active]
541229007167	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229007168	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229007169	Protein of unknown function (DUF3947); Region: DUF3947; pfam13135
541229007170	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
541229007171	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
541229007172	active site
541229007173	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
541229007174	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
541229007175	YolD-like protein; Region: YolD; pfam08863
541229007176	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
541229007177	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
541229007178	classical (c) SDRs; Region: SDR_c; cd05233
541229007179	NAD(P) binding site [chemical binding]; other site
541229007180	active site
541229007181	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
541229007182	KTSC domain; Region: KTSC; pfam13619
541229007183	Transglycosylase; Region: Transgly; pfam00912
541229007184	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
541229007185	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229007186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229007188	putative substrate translocation pore; other site
541229007189	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
541229007190	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
541229007191	dimer interface [polypeptide binding]; other site
541229007192	Citrate synthase; Region: Citrate_synt; pfam00285
541229007193	active site
541229007194	coenzyme A binding site [chemical binding]; other site
541229007195	citrylCoA binding site [chemical binding]; other site
541229007196	oxalacetate/citrate binding site [chemical binding]; other site
541229007197	catalytic triad [active]
541229007198	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
541229007199	2-methylcitrate dehydratase; Region: prpD; TIGR02330
541229007200	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
541229007201	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
541229007202	tetramer interface [polypeptide binding]; other site
541229007203	active site
541229007204	Mg2+/Mn2+ binding site [ion binding]; other site
541229007205	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
541229007206	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
541229007207	active site
541229007208	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
541229007209	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
541229007210	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
541229007211	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
541229007212	tetrameric interface [polypeptide binding]; other site
541229007213	NAD binding site [chemical binding]; other site
541229007214	catalytic residues [active]
541229007215	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
541229007216	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
541229007217	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
541229007218	substrate binding site [chemical binding]; other site
541229007219	oxyanion hole (OAH) forming residues; other site
541229007220	trimer interface [polypeptide binding]; other site
541229007221	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
541229007222	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
541229007223	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
541229007224	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
541229007225	active site
541229007226	metal binding site [ion binding]; metal-binding site
541229007227	DNA binding site [nucleotide binding]
541229007228	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
541229007229	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
541229007230	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
541229007231	Walker A/P-loop; other site
541229007232	ATP binding site [chemical binding]; other site
541229007233	Q-loop/lid; other site
541229007234	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
541229007235	ABC transporter signature motif; other site
541229007236	Walker B; other site
541229007237	D-loop; other site
541229007238	H-loop/switch region; other site
541229007239	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229007240	dimerization interface [polypeptide binding]; other site
541229007241	putative DNA binding site [nucleotide binding]; other site
541229007242	putative Zn2+ binding site [ion binding]; other site
541229007243	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
541229007244	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
541229007245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007246	putative substrate translocation pore; other site
541229007247	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
541229007248	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
541229007249	putative NAD(P) binding site [chemical binding]; other site
541229007250	active site
541229007251	isochorismate synthase DhbC; Validated; Region: PRK06923
541229007252	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
541229007253	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
541229007254	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
541229007255	acyl-activating enzyme (AAE) consensus motif; other site
541229007256	active site
541229007257	AMP binding site [chemical binding]; other site
541229007258	substrate binding site [chemical binding]; other site
541229007259	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
541229007260	hydrophobic substrate binding pocket; other site
541229007261	Isochorismatase family; Region: Isochorismatase; pfam00857
541229007262	active site
541229007263	conserved cis-peptide bond; other site
541229007264	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
541229007265	Condensation domain; Region: Condensation; pfam00668
541229007266	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
541229007267	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
541229007268	acyl-activating enzyme (AAE) consensus motif; other site
541229007269	AMP binding site [chemical binding]; other site
541229007270	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007271	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
541229007272	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
541229007273	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007274	acyl-activating enzyme (AAE) consensus motif; other site
541229007275	AMP binding site [chemical binding]; other site
541229007276	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007277	MbtH-like protein; Region: MbtH; pfam03621
541229007278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007279	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229007280	putative substrate translocation pore; other site
541229007281	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
541229007282	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
541229007283	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
541229007284	IHF dimer interface [polypeptide binding]; other site
541229007285	IHF - DNA interface [nucleotide binding]; other site
541229007286	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
541229007287	DinB family; Region: DinB; cl17821
541229007288	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
541229007289	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
541229007290	active site
541229007291	catalytic triad [active]
541229007292	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229007293	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
541229007294	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
541229007295	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229007296	RNA binding surface [nucleotide binding]; other site
541229007297	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
541229007298	probable active site [active]
541229007299	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
541229007300	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
541229007301	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
541229007302	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
541229007303	active site
541229007304	dimer interface [polypeptide binding]; other site
541229007305	motif 1; other site
541229007306	motif 2; other site
541229007307	motif 3; other site
541229007308	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
541229007309	anticodon binding site; other site
541229007310	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229007311	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229007312	Walker A/P-loop; other site
541229007313	ATP binding site [chemical binding]; other site
541229007314	Q-loop/lid; other site
541229007315	ABC transporter signature motif; other site
541229007316	Walker B; other site
541229007317	D-loop; other site
541229007318	H-loop/switch region; other site
541229007319	FtsX-like permease family; Region: FtsX; pfam02687
541229007320	FtsX-like permease family; Region: FtsX; pfam02687
541229007321	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229007322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
541229007324	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
541229007325	pyruvate oxidase; Provisional; Region: PRK08611
541229007326	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
541229007327	PYR/PP interface [polypeptide binding]; other site
541229007328	dimer interface [polypeptide binding]; other site
541229007329	tetramer interface [polypeptide binding]; other site
541229007330	TPP binding site [chemical binding]; other site
541229007331	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
541229007332	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
541229007333	TPP-binding site [chemical binding]; other site
541229007334	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
541229007335	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229007336	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
541229007337	active site
541229007338	dimerization interface [polypeptide binding]; other site
541229007339	Protein of unknown function (DUF2441); Region: DUF2441; pfam10386
541229007340	Protein of unknown function, DUF606; Region: DUF606; pfam04657
541229007341	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
541229007342	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
541229007343	ligand binding site [chemical binding]; other site
541229007344	flexible hinge region; other site
541229007345	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
541229007346	Protein of unknown function, DUF606; Region: DUF606; pfam04657
541229007347	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
541229007348	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
541229007349	Transcriptional regulators [Transcription]; Region: MarR; COG1846
541229007350	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
541229007351	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
541229007352	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229007353	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229007354	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229007355	MMPL family; Region: MMPL; pfam03176
541229007356	MMPL family; Region: MMPL; pfam03176
541229007357	Protein of unknown function (DUF4021); Region: DUF4021; pfam13213
541229007358	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
541229007359	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
541229007360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229007361	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229007362	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229007363	Coenzyme A binding pocket [chemical binding]; other site
541229007364	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229007365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229007366	Coenzyme A binding pocket [chemical binding]; other site
541229007367	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
541229007368	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
541229007369	putative acetyltransferase YhhY; Provisional; Region: PRK10140
541229007370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229007371	Coenzyme A binding pocket [chemical binding]; other site
541229007372	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229007373	EamA-like transporter family; Region: EamA; pfam00892
541229007374	EamA-like transporter family; Region: EamA; pfam00892
541229007375	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
541229007376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229007377	non-specific DNA binding site [nucleotide binding]; other site
541229007378	salt bridge; other site
541229007379	sequence-specific DNA binding site [nucleotide binding]; other site
541229007380	Cupin domain; Region: Cupin_2; pfam07883
541229007381	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
541229007382	protoporphyrinogen oxidase; Provisional; Region: PRK12416
541229007383	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229007384	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229007385	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229007386	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229007387	Cold-inducible protein YdjO; Region: YdjO; pfam14169
541229007388	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
541229007389	DNA-binding site [nucleotide binding]; DNA binding site
541229007390	RNA-binding motif; other site
541229007391	CAAX protease self-immunity; Region: Abi; pfam02517
541229007392	AAA domain; Region: AAA_17; pfam13207
541229007393	AAA domain; Region: AAA_18; pfam13238
541229007394	hypothetical protein; Provisional; Region: PRK06770
541229007395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229007396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229007397	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229007398	dimerization interface [polypeptide binding]; other site
541229007399	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728
541229007400	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
541229007401	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
541229007402	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
541229007403	active site
541229007404	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
541229007405	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
541229007406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229007407	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229007408	dimerization interface [polypeptide binding]; other site
541229007409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
541229007410	MOSC domain; Region: MOSC; pfam03473
541229007411	3-alpha domain; Region: 3-alpha; pfam03475
541229007412	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
541229007413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229007414	Coenzyme A binding pocket [chemical binding]; other site
541229007415	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
541229007416	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229007417	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229007418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229007419	Walker A/P-loop; other site
541229007420	ATP binding site [chemical binding]; other site
541229007421	Q-loop/lid; other site
541229007422	ABC transporter signature motif; other site
541229007423	Walker B; other site
541229007424	D-loop; other site
541229007425	H-loop/switch region; other site
541229007426	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229007427	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229007428	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
541229007429	Walker A/P-loop; other site
541229007430	ATP binding site [chemical binding]; other site
541229007431	Q-loop/lid; other site
541229007432	ABC transporter signature motif; other site
541229007433	Walker B; other site
541229007434	D-loop; other site
541229007435	H-loop/switch region; other site
541229007436	potential frameshift: common BLAST hit: gi|217961387|ref|YP_002339955.1| MazG nucleotide pyrophosphohydrolase domain family protein
541229007437	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
541229007438	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
541229007439	Septum formation initiator; Region: DivIC; cl17659
541229007440	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
541229007441	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
541229007442	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
541229007443	Int/Topo IB signature motif; other site
541229007444	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229007445	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
541229007446	TAP-like protein; Region: Abhydrolase_4; pfam08386
541229007447	Homeodomain-like domain; Region: HTH_23; pfam13384
541229007448	Phage terminase, small subunit; Region: Terminase_4; cl01525
541229007449	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
541229007450	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229007451	amidase catalytic site [active]
541229007452	Zn binding residues [ion binding]; other site
541229007453	substrate binding site [chemical binding]; other site
541229007454	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229007455	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
541229007456	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
541229007457	LysE type translocator; Region: LysE; cl00565
541229007458	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
541229007459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229007460	non-specific DNA binding site [nucleotide binding]; other site
541229007461	salt bridge; other site
541229007462	sequence-specific DNA binding site [nucleotide binding]; other site
541229007463	Cupin domain; Region: Cupin_2; pfam07883
541229007464	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
541229007465	Domain of unknown function (DUF4183); Region: DUF4183; pfam13799
541229007466	BclB C-terminal domain; Region: exospore_TM; TIGR03721
541229007467	Cupin; Region: Cupin_1; smart00835
541229007468	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
541229007469	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229007470	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
541229007471	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229007472	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
541229007473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
541229007474	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
541229007475	Domain of unknown function (DUF3974); Region: DUF3974; pfam13120
541229007476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
541229007477	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
541229007478	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
541229007479	active site
541229007480	P-loop; other site
541229007481	phosphorylation site [posttranslational modification]
541229007482	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
541229007483	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
541229007484	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
541229007485	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
541229007486	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
541229007487	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
541229007488	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
541229007489	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229007490	catalytic residue [active]
541229007491	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
541229007492	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
541229007493	tetramer interface [polypeptide binding]; other site
541229007494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229007495	catalytic residue [active]
541229007496	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229007497	MarR family; Region: MarR; pfam01047
541229007498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007499	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229007500	putative substrate translocation pore; other site
541229007501	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229007502	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
541229007503	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
541229007504	ATP binding site [chemical binding]; other site
541229007505	Mg++ binding site [ion binding]; other site
541229007506	motif III; other site
541229007507	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229007508	nucleotide binding region [chemical binding]; other site
541229007509	ATP-binding site [chemical binding]; other site
541229007510	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229007511	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229007512	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229007513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007514	putative substrate translocation pore; other site
541229007515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229007516	Q-loop/lid; other site
541229007517	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229007518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229007519	S-adenosylmethionine binding site [chemical binding]; other site
541229007520	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
541229007521	dimer interface [polypeptide binding]; other site
541229007522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229007523	S-adenosylmethionine binding site [chemical binding]; other site
541229007524	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
541229007525	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
541229007526	dimer interface [polypeptide binding]; other site
541229007527	PYR/PP interface [polypeptide binding]; other site
541229007528	TPP binding site [chemical binding]; other site
541229007529	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
541229007530	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
541229007531	TPP-binding site [chemical binding]; other site
541229007532	dimer interface [polypeptide binding]; other site
541229007533	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229007534	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229007535	putative DNA binding site [nucleotide binding]; other site
541229007536	putative Zn2+ binding site [ion binding]; other site
541229007537	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229007538	catalytic core [active]
541229007539	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229007540	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
541229007541	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
541229007542	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
541229007543	metal binding site [ion binding]; metal-binding site
541229007544	dimer interface [polypeptide binding]; other site
541229007545	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
541229007546	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
541229007547	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
541229007548	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229007549	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229007550	DNA binding residues [nucleotide binding]
541229007551	dimerization interface [polypeptide binding]; other site
541229007552	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229007553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229007554	non-specific DNA binding site [nucleotide binding]; other site
541229007555	salt bridge; other site
541229007556	sequence-specific DNA binding site [nucleotide binding]; other site
541229007557	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229007558	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229007559	Cut8; Region: Cut8; pfam08559
541229007560	hypothetical protein; Provisional; Region: PRK10621
541229007561	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229007562	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
541229007563	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
541229007564	trimer interface [polypeptide binding]; other site
541229007565	active site
541229007566	substrate binding site [chemical binding]; other site
541229007567	CoA binding site [chemical binding]; other site
541229007568	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
541229007569	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229007570	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
541229007571	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
541229007572	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
541229007573	active site
541229007574	catalytic triad [active]
541229007575	oxyanion hole [active]
541229007576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229007577	putative substrate translocation pore; other site
541229007578	Condensation domain; Region: Condensation; pfam00668
541229007579	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229007580	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
541229007581	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007582	acyl-activating enzyme (AAE) consensus motif; other site
541229007583	AMP binding site [chemical binding]; other site
541229007584	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007585	Condensation domain; Region: Condensation; pfam00668
541229007586	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229007587	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
541229007588	Condensation domain; Region: Condensation; pfam00668
541229007589	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229007590	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007591	acyl-activating enzyme (AAE) consensus motif; other site
541229007592	AMP binding site [chemical binding]; other site
541229007593	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007594	Condensation domain; Region: Condensation; pfam00668
541229007595	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229007596	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
541229007597	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
541229007598	acyl-activating enzyme (AAE) consensus motif; other site
541229007599	AMP binding site [chemical binding]; other site
541229007600	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007601	Condensation domain; Region: Condensation; pfam00668
541229007602	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229007603	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
541229007604	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007605	acyl-activating enzyme (AAE) consensus motif; other site
541229007606	AMP binding site [chemical binding]; other site
541229007607	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007608	peptide synthase; Provisional; Region: PRK12467
541229007609	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
541229007610	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007611	acyl-activating enzyme (AAE) consensus motif; other site
541229007612	AMP binding site [chemical binding]; other site
541229007613	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007614	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
541229007615	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007616	acyl-activating enzyme (AAE) consensus motif; other site
541229007617	AMP binding site [chemical binding]; other site
541229007618	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007619	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
541229007620	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229007621	acyl-activating enzyme (AAE) consensus motif; other site
541229007622	AMP binding site [chemical binding]; other site
541229007623	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229007624	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
541229007625	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
541229007626	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
541229007627	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
541229007628	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
541229007629	transmembrane helices; other site
541229007630	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229007631	amino acid carrier protein; Region: agcS; TIGR00835
541229007632	glutaminase; Reviewed; Region: PRK12357
541229007633	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
541229007634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229007635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229007636	ATP binding site [chemical binding]; other site
541229007637	Mg2+ binding site [ion binding]; other site
541229007638	G-X-G motif; other site
541229007639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229007640	Response regulator receiver domain; Region: Response_reg; pfam00072
541229007641	active site
541229007642	phosphorylation site [posttranslational modification]
541229007643	intermolecular recognition site; other site
541229007644	dimerization interface [polypeptide binding]; other site
541229007645	YcbB domain; Region: YcbB; pfam08664
541229007646	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229007647	Spore germination protein; Region: Spore_permease; pfam03845
541229007648	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
541229007649	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
541229007650	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491
541229007651	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
541229007652	amino acid transporter; Region: 2A0306; TIGR00909
541229007653	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
541229007654	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
541229007655	GIY-YIG motif/motif A; other site
541229007656	active site
541229007657	catalytic site [active]
541229007658	putative DNA binding site [nucleotide binding]; other site
541229007659	metal binding site [ion binding]; metal-binding site
541229007660	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
541229007661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229007662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229007663	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229007664	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229007665	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229007666	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
541229007667	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
541229007668	PAS fold; Region: PAS_4; pfam08448
541229007669	PAS domain S-box; Region: sensory_box; TIGR00229
541229007670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229007671	putative active site [active]
541229007672	heme pocket [chemical binding]; other site
541229007673	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
541229007674	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229007675	putative active site [active]
541229007676	heme pocket [chemical binding]; other site
541229007677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229007678	dimer interface [polypeptide binding]; other site
541229007679	phosphorylation site [posttranslational modification]
541229007680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229007681	ATP binding site [chemical binding]; other site
541229007682	Mg2+ binding site [ion binding]; other site
541229007683	G-X-G motif; other site
541229007684	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229007685	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229007686	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
541229007687	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
541229007688	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
541229007689	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
541229007690	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
541229007691	active site
541229007692	nucleophile elbow; other site
541229007693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229007694	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229007695	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229007696	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
541229007697	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
541229007698	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229007699	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
541229007700	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229007701	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
541229007702	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229007703	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229007704	DNA binding residues [nucleotide binding]
541229007705	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
541229007706	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229007707	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229007708	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229007709	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229007710	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229007711	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229007712	beta-lactamase TEM; Provisional; Region: PRK15442
541229007713	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
541229007714	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
541229007715	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229007716	putative active site [active]
541229007717	putative metal binding site [ion binding]; other site
541229007718	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
541229007719	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229007720	Walker A/P-loop; other site
541229007721	ATP binding site [chemical binding]; other site
541229007722	Q-loop/lid; other site
541229007723	ABC transporter signature motif; other site
541229007724	Walker B; other site
541229007725	D-loop; other site
541229007726	H-loop/switch region; other site
541229007727	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
541229007728	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
541229007729	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229007730	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229007731	Protein of unknown function (DUF523); Region: DUF523; pfam04463
541229007732	Uncharacterized conserved protein [Function unknown]; Region: COG3272
541229007733	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
541229007734	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
541229007735	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
541229007736	FAD binding site [chemical binding]; other site
541229007737	homotetramer interface [polypeptide binding]; other site
541229007738	substrate binding pocket [chemical binding]; other site
541229007739	catalytic base [active]
541229007740	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
541229007741	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
541229007742	ATP-grasp domain; Region: ATP-grasp_4; cl17255
541229007743	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
541229007744	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
541229007745	carboxyltransferase (CT) interaction site; other site
541229007746	biotinylation site [posttranslational modification]; other site
541229007747	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
541229007748	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
541229007749	active site
541229007750	catalytic residues [active]
541229007751	metal binding site [ion binding]; metal-binding site
541229007752	enoyl-CoA hydratase; Provisional; Region: PRK07657
541229007753	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
541229007754	substrate binding site [chemical binding]; other site
541229007755	oxyanion hole (OAH) forming residues; other site
541229007756	trimer interface [polypeptide binding]; other site
541229007757	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
541229007758	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
541229007759	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
541229007760	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
541229007761	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
541229007762	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
541229007763	acyl-activating enzyme (AAE) consensus motif; other site
541229007764	putative AMP binding site [chemical binding]; other site
541229007765	putative active site [active]
541229007766	putative CoA binding site [chemical binding]; other site
541229007767	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229007768	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229007769	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229007770	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229007771	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229007772	Coenzyme A binding pocket [chemical binding]; other site
541229007773	Protein of unknown function (DUF3956); Region: DUF3956; pfam13104
541229007774	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229007775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229007776	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229007777	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
541229007778	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229007779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229007780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229007781	dimer interface [polypeptide binding]; other site
541229007782	phosphorylation site [posttranslational modification]
541229007783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229007784	ATP binding site [chemical binding]; other site
541229007785	Mg2+ binding site [ion binding]; other site
541229007786	G-X-G motif; other site
541229007787	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229007788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229007789	active site
541229007790	phosphorylation site [posttranslational modification]
541229007791	intermolecular recognition site; other site
541229007792	dimerization interface [polypeptide binding]; other site
541229007793	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229007794	DNA binding site [nucleotide binding]
541229007795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229007796	Zn2+ binding site [ion binding]; other site
541229007797	Mg2+ binding site [ion binding]; other site
541229007798	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
541229007799	S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714
541229007800	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229007801	Coenzyme A binding pocket [chemical binding]; other site
541229007802	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
541229007803	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229007804	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229007805	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
541229007806	active site
541229007807	Zn binding site [ion binding]; other site
541229007808	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
541229007809	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
541229007810	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
541229007811	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
541229007812	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229007813	Cna protein B-type domain; Region: Cna_B; pfam05738
541229007814	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
541229007815	Cna protein B-type domain; Region: Cna_B; pfam05738
541229007816	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
541229007817	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
541229007818	active site
541229007819	catalytic site [active]
541229007820	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
541229007821	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
541229007822	Cna protein B-type domain; Region: Cna_B; pfam05738
541229007823	Cna protein B-type domain; Region: Cna_B; pfam05738
541229007824	Cna protein B-type domain; Region: Cna_B; pfam05738
541229007825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
541229007826	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
541229007827	putative hydrophobic ligand binding site [chemical binding]; other site
541229007828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229007829	AAA domain; Region: AAA_21; pfam13304
541229007830	Walker A/P-loop; other site
541229007831	ATP binding site [chemical binding]; other site
541229007832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229007833	ABC transporter signature motif; other site
541229007834	Walker B; other site
541229007835	D-loop; other site
541229007836	H-loop/switch region; other site
541229007837	ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238
541229007838	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
541229007839	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
541229007840	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
541229007841	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229007842	DNA binding residues [nucleotide binding]
541229007843	drug binding residues [chemical binding]; other site
541229007844	dimer interface [polypeptide binding]; other site
541229007845	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
541229007846	short chain dehydrogenase; Provisional; Region: PRK07041
541229007847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229007848	NAD(P) binding site [chemical binding]; other site
541229007849	active site
541229007850	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
541229007851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229007852	Integrase core domain; Region: rve; pfam00665
541229007853	transposase/IS protein; Provisional; Region: PRK09183
541229007854	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229007855	Walker A motif; other site
541229007856	ATP binding site [chemical binding]; other site
541229007857	Walker B motif; other site
541229007858	arginine finger; other site
541229007859	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229007860	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
541229007861	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229007862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229007863	S-adenosylmethionine binding site [chemical binding]; other site
541229007864	Phosphotransferase enzyme family; Region: APH; pfam01636
541229007865	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
541229007866	active site
541229007867	substrate binding site [chemical binding]; other site
541229007868	ATP binding site [chemical binding]; other site
541229007869	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229007870	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
541229007871	active site
541229007872	ATP binding site [chemical binding]; other site
541229007873	substrate binding site [chemical binding]; other site
541229007874	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
541229007875	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229007876	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
541229007877	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
541229007878	active site
541229007879	Zn binding site [ion binding]; other site
541229007880	Protein of unknown function (DUF4030); Region: DUF4030; pfam13222
541229007881	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229007882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229007883	DNA-binding site [nucleotide binding]; DNA binding site
541229007884	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229007885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229007886	homodimer interface [polypeptide binding]; other site
541229007887	catalytic residue [active]
541229007888	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
541229007889	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
541229007890	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
541229007891	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
541229007892	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
541229007893	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
541229007894	putative NAD(P) binding site [chemical binding]; other site
541229007895	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
541229007896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229007897	NAD(P) binding site [chemical binding]; other site
541229007898	active site
541229007899	Predicted membrane protein [Function unknown]; Region: COG2323
541229007900	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229007901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229007902	S-adenosylmethionine binding site [chemical binding]; other site
541229007903	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
541229007904	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
541229007905	conserved cys residue [active]
541229007906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229007907	S-adenosylmethionine binding site [chemical binding]; other site
541229007908	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
541229007909	Strictosidine synthase; Region: Str_synth; pfam03088
541229007910	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
541229007911	catalytic core domain of  class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674
541229007912	active site
541229007913	HIGH motif; other site
541229007914	KMSKS motif; other site
541229007915	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
541229007916	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
541229007917	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229007918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229007919	active site
541229007920	phosphorylation site [posttranslational modification]
541229007921	intermolecular recognition site; other site
541229007922	dimerization interface [polypeptide binding]; other site
541229007923	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229007924	DNA binding site [nucleotide binding]
541229007925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229007926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
541229007927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229007928	ATP binding site [chemical binding]; other site
541229007929	Mg2+ binding site [ion binding]; other site
541229007930	G-X-G motif; other site
541229007931	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
541229007932	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229007933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229007934	ABC transporter; Region: ABC_tran_2; pfam12848
541229007935	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229007936	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229007937	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229007938	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
541229007939	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229007940	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229007941	Walker A/P-loop; other site
541229007942	ATP binding site [chemical binding]; other site
541229007943	Q-loop/lid; other site
541229007944	ABC transporter signature motif; other site
541229007945	Walker B; other site
541229007946	D-loop; other site
541229007947	H-loop/switch region; other site
541229007948	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229007949	FtsX-like permease family; Region: FtsX; pfam02687
541229007950	hypothetical protein; Provisional; Region: PRK06760
541229007951	Protein of unknown function (DUF3914); Region: DUF3914; pfam13053
541229007952	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
541229007953	homoserine dehydrogenase; Validated; Region: PRK06813
541229007954	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
541229007955	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229007956	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229007957	DNA-binding site [nucleotide binding]; DNA binding site
541229007958	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229007959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229007960	homodimer interface [polypeptide binding]; other site
541229007961	catalytic residue [active]
541229007962	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
541229007963	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
541229007964	ATP-grasp domain; Region: ATP-grasp_4; cl17255
541229007965	Putative transcription activator [Transcription]; Region: TenA; COG0819
541229007966	Protein of unknown function (DUF3937); Region: DUF3937; pfam13073
541229007967	probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601
541229007968	Protein of unknown function (DUF3962); Region: DUF3962; pfam13111
541229007969	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
541229007970	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
541229007971	Int/Topo IB signature motif; other site
541229007972	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229007973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229007974	non-specific DNA binding site [nucleotide binding]; other site
541229007975	salt bridge; other site
541229007976	sequence-specific DNA binding site [nucleotide binding]; other site
541229007977	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229007978	non-specific DNA binding site [nucleotide binding]; other site
541229007979	salt bridge; other site
541229007980	sequence-specific DNA binding site [nucleotide binding]; other site
541229007981	Helix-turn-helix domain; Region: HTH_17; pfam12728
541229007982	Helix-turn-helix domain; Region: HTH_36; pfam13730
541229007983	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229007984	hypothetical protein; Validated; Region: PRK08116
541229007985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229007986	Walker A motif; other site
541229007987	ATP binding site [chemical binding]; other site
541229007988	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
541229007989	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229007990	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
541229007991	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
541229007992	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
541229007993	Septum formation initiator; Region: DivIC; cl17659
541229007994	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
541229007995	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
541229007996	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
541229007997	Int/Topo IB signature motif; other site
541229007998	Homeodomain-like domain; Region: HTH_23; pfam13384
541229007999	Phage terminase, small subunit; Region: Terminase_4; cl01525
541229008000	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
541229008001	Phage portal protein; Region: Phage_portal; pfam04860
541229008002	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
541229008003	oligomer interface [polypeptide binding]; other site
541229008004	active site residues [active]
541229008005	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
541229008006	Phage capsid family; Region: Phage_capsid; pfam05065
541229008007	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
541229008008	Phage-related protein [Function unknown]; Region: COG5412
541229008009	Phage-related protein [Function unknown]; Region: COG4722
541229008010	Phage tail protein; Region: Sipho_tail; cl17486
541229008011	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
541229008012	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
541229008013	vacuolar sorting protein SNF7-like; Provisional; Region: PTZ00446
541229008014	Haemolysin XhlA; Region: XhlA; pfam10779
541229008015	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229008016	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229008017	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229008018	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229008019	amidase catalytic site [active]
541229008020	Zn binding residues [ion binding]; other site
541229008021	substrate binding site [chemical binding]; other site
541229008022	Bacterial SH3 domain; Region: SH3_3; cl17532
541229008023	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229008024	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
541229008025	Protein of unknown function (DUF3959); Region: DUF3959; pfam13105
541229008026	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
541229008027	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
541229008028	Protein of unknown function; Region: DUF3658; pfam12395
541229008029	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
541229008030	Cytochrome P450; Region: p450; cl12078
541229008031	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
541229008032	trimer interface [polypeptide binding]; other site
541229008033	active site
541229008034	substrate binding site [chemical binding]; other site
541229008035	CoA binding site [chemical binding]; other site
541229008036	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
541229008037	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229008038	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229008039	Cytochrome P450; Region: p450; cl12078
541229008040	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
541229008041	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
541229008042	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229008043	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229008044	active site
541229008045	motif I; other site
541229008046	motif II; other site
541229008047	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229008048	PAS domain S-box; Region: sensory_box; TIGR00229
541229008049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229008050	putative active site [active]
541229008051	heme pocket [chemical binding]; other site
541229008052	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
541229008053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229008054	dimer interface [polypeptide binding]; other site
541229008055	phosphorylation site [posttranslational modification]
541229008056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229008057	ATP binding site [chemical binding]; other site
541229008058	Mg2+ binding site [ion binding]; other site
541229008059	G-X-G motif; other site
541229008060	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229008061	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229008062	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229008063	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229008064	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
541229008065	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229008066	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
541229008067	glycosyltransferase, MGT family; Region: MGT; TIGR01426
541229008068	active site
541229008069	TDP-binding site; other site
541229008070	acceptor substrate-binding pocket; other site
541229008071	homodimer interface [polypeptide binding]; other site
541229008072	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
541229008073	aspartate racemase; Region: asp_race; TIGR00035
541229008074	hypothetical protein; Provisional; Region: PRK13661
541229008075	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229008076	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
541229008077	Walker A/P-loop; other site
541229008078	ATP binding site [chemical binding]; other site
541229008079	Q-loop/lid; other site
541229008080	ABC transporter signature motif; other site
541229008081	Walker B; other site
541229008082	D-loop; other site
541229008083	H-loop/switch region; other site
541229008084	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
541229008085	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229008086	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
541229008087	Walker A/P-loop; other site
541229008088	ATP binding site [chemical binding]; other site
541229008089	Q-loop/lid; other site
541229008090	ABC transporter signature motif; other site
541229008091	Walker B; other site
541229008092	D-loop; other site
541229008093	H-loop/switch region; other site
541229008094	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
541229008095	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
541229008096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229008097	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229008098	dimer interface [polypeptide binding]; other site
541229008099	phosphorylation site [posttranslational modification]
541229008100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229008101	ATP binding site [chemical binding]; other site
541229008102	Mg2+ binding site [ion binding]; other site
541229008103	G-X-G motif; other site
541229008104	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
541229008105	nudix motif; other site
541229008106	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
541229008107	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
541229008108	active site
541229008109	ATP binding site [chemical binding]; other site
541229008110	substrate binding site [chemical binding]; other site
541229008111	activation loop (A-loop); other site
541229008112	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
541229008113	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229008114	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
541229008115	NAD(P) binding site [chemical binding]; other site
541229008116	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
541229008117	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
541229008118	active site
541229008119	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229008120	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229008121	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229008122	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
541229008123	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
541229008124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008125	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229008126	putative substrate translocation pore; other site
541229008127	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229008128	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229008129	VanZ like family; Region: VanZ; pfam04892
541229008130	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
541229008131	EDD domain protein, DegV family; Region: DegV; TIGR00762
541229008132	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
541229008133	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229008134	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229008135	non-specific DNA binding site [nucleotide binding]; other site
541229008136	salt bridge; other site
541229008137	sequence-specific DNA binding site [nucleotide binding]; other site
541229008138	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
541229008139	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229008140	DNA binding residues [nucleotide binding]
541229008141	Trm112p-like protein; Region: Trm112p; pfam03966
541229008142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229008143	S-adenosylmethionine binding site [chemical binding]; other site
541229008144	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008145	Coenzyme A binding pocket [chemical binding]; other site
541229008146	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
541229008147	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
541229008148	active site
541229008149	catalytic site [active]
541229008150	metal binding site [ion binding]; metal-binding site
541229008151	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
541229008152	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229008153	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229008154	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
541229008155	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229008156	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229008157	DNA-binding site [nucleotide binding]; DNA binding site
541229008158	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229008159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229008160	homodimer interface [polypeptide binding]; other site
541229008161	catalytic residue [active]
541229008162	EamA-like transporter family; Region: EamA; pfam00892
541229008163	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229008164	EamA-like transporter family; Region: EamA; pfam00892
541229008165	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
541229008166	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
541229008167	active site
541229008168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008169	Coenzyme A binding pocket [chemical binding]; other site
541229008170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
541229008171	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689
541229008172	nudix motif; other site
541229008173	probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601
541229008174	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229008175	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229008176	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
541229008177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008178	putative substrate translocation pore; other site
541229008179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229008180	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008181	Coenzyme A binding pocket [chemical binding]; other site
541229008182	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229008183	nudix motif; other site
541229008184	DNA polymerase III subunit beta; Validated; Region: PRK06673
541229008185	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
541229008186	putative DNA binding surface [nucleotide binding]; other site
541229008187	dimer interface [polypeptide binding]; other site
541229008188	beta-clamp/clamp loader binding surface; other site
541229008189	beta-clamp/translesion DNA polymerase binding surface; other site
541229008190	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
541229008191	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
541229008192	translation initiation factor IF-2; Provisional; Region: PRK14845
541229008193	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
541229008194	homotrimer interaction site [polypeptide binding]; other site
541229008195	putative active site [active]
541229008196	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
541229008197	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
541229008198	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
541229008199	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
541229008200	YxiJ-like protein; Region: YxiJ; pfam14176
541229008201	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
541229008202	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
541229008203	active site
541229008204	nucleophile elbow; other site
541229008205	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
541229008206	pentamer interface [polypeptide binding]; other site
541229008207	dodecaamer interface [polypeptide binding]; other site
541229008208	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229008209	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008210	Coenzyme A binding pocket [chemical binding]; other site
541229008211	metal-dependent hydrolase; Provisional; Region: PRK13291
541229008212	DinB superfamily; Region: DinB_2; pfam12867
541229008213	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008214	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229008215	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
541229008216	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
541229008217	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
541229008218	GIY-YIG motif/motif A; other site
541229008219	active site
541229008220	catalytic site [active]
541229008221	putative DNA binding site [nucleotide binding]; other site
541229008222	metal binding site [ion binding]; metal-binding site
541229008223	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008225	Coenzyme A binding pocket [chemical binding]; other site
541229008226	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
541229008227	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
541229008228	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
541229008229	active site
541229008230	ATP binding site [chemical binding]; other site
541229008231	substrate binding site [chemical binding]; other site
541229008232	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
541229008233	nudix motif; other site
541229008234	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
541229008235	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229008236	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
541229008237	MepB protein; Region: MepB; pfam08877
541229008238	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
541229008239	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
541229008240	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229008241	motif II; other site
541229008242	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
541229008243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229008244	active site
541229008245	phosphorylation site [posttranslational modification]
541229008246	intermolecular recognition site; other site
541229008247	dimerization interface [polypeptide binding]; other site
541229008248	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229008249	DNA binding site [nucleotide binding]
541229008250	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
541229008251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229008252	dimerization interface [polypeptide binding]; other site
541229008253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229008254	dimer interface [polypeptide binding]; other site
541229008255	phosphorylation site [posttranslational modification]
541229008256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229008257	ATP binding site [chemical binding]; other site
541229008258	Mg2+ binding site [ion binding]; other site
541229008259	G-X-G motif; other site
541229008260	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
541229008261	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229008262	putative DNA binding site [nucleotide binding]; other site
541229008263	putative Zn2+ binding site [ion binding]; other site
541229008264	AsnC family; Region: AsnC_trans_reg; pfam01037
541229008265	DinB superfamily; Region: DinB_2; pfam12867
541229008266	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
541229008267	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229008268	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229008269	Walker A/P-loop; other site
541229008270	ATP binding site [chemical binding]; other site
541229008271	Q-loop/lid; other site
541229008272	ABC transporter signature motif; other site
541229008273	Walker B; other site
541229008274	D-loop; other site
541229008275	H-loop/switch region; other site
541229008276	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
541229008277	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229008278	FtsX-like permease family; Region: FtsX; pfam02687
541229008279	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229008280	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
541229008281	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
541229008282	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229008283	tyrosine decarboxylase; Region: PLN02880
541229008284	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
541229008285	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229008286	catalytic residue [active]
541229008287	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
541229008288	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
541229008289	acyl-activating enzyme (AAE) consensus motif; other site
541229008290	AMP binding site [chemical binding]; other site
541229008291	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229008292	Condensation domain; Region: Condensation; pfam00668
541229008293	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229008294	Nonribosomal peptide synthase; Region: NRPS; pfam08415
541229008295	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
541229008296	acyl-activating enzyme (AAE) consensus motif; other site
541229008297	AMP binding site [chemical binding]; other site
541229008298	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
541229008299	Condensation domain; Region: Condensation; pfam00668
541229008300	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
541229008301	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
541229008302	putative FMN binding site [chemical binding]; other site
541229008303	NADPH bind site [chemical binding]; other site
541229008304	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
541229008305	carbohydrate binding site [chemical binding]; other site
541229008306	pullulanase, type I; Region: pulA_typeI; TIGR02104
541229008307	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
541229008308	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
541229008309	Ca binding site [ion binding]; other site
541229008310	active site
541229008311	catalytic site [active]
541229008312	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229008313	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229008314	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
541229008315	active site
541229008316	Zn binding site [ion binding]; other site
541229008317	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
541229008318	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
541229008319	active site
541229008320	metal binding site [ion binding]; metal-binding site
541229008321	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
541229008322	DinB superfamily; Region: DinB_2; pfam12867
541229008323	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
541229008324	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907
541229008325	SecY translocase; Region: SecY; pfam00344
541229008326	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229008327	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229008328	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
541229008329	hypothetical protein; Provisional; Region: PRK07236
541229008330	FAD binding domain; Region: FAD_binding_3; pfam01494
541229008331	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
541229008332	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
541229008333	EamA-like transporter family; Region: EamA; pfam00892
541229008334	EamA-like transporter family; Region: EamA; pfam00892
541229008335	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229008336	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229008337	DNA-binding site [nucleotide binding]; DNA binding site
541229008338	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229008339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229008340	homodimer interface [polypeptide binding]; other site
541229008341	catalytic residue [active]
541229008342	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229008343	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
541229008344	putative NAD(P) binding site [chemical binding]; other site
541229008345	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
541229008346	TAP-like protein; Region: Abhydrolase_4; pfam08386
541229008347	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
541229008348	Mg binding site [ion binding]; other site
541229008349	nucleotide binding site [chemical binding]; other site
541229008350	putative protofilament interface [polypeptide binding]; other site
541229008351	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
541229008352	Predicted membrane protein [Function unknown]; Region: COG4129
541229008353	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
541229008354	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229008355	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
541229008356	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
541229008357	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
541229008358	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
541229008359	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
541229008360	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
541229008361	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229008362	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229008363	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
541229008364	arylformamidase; Region: trp_arylform; TIGR03035
541229008365	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
541229008366	kynureninase; Region: kynureninase; TIGR01814
541229008367	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229008368	catalytic residue [active]
541229008369	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229008370	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229008371	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229008372	nudix motif; other site
541229008373	N-acetyltransferase; Region: Acetyltransf_2; cl00949
541229008374	Major royal jelly protein; Region: MRJP; pfam03022
541229008375	Protein of unknown function (DUF3977); Region: DUF3977; pfam13122
541229008376	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
541229008377	GAF domain; Region: GAF; pfam01590
541229008378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229008379	Walker A motif; other site
541229008380	ATP binding site [chemical binding]; other site
541229008381	Walker B motif; other site
541229008382	arginine finger; other site
541229008383	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
541229008384	NIPSNAP; Region: NIPSNAP; pfam07978
541229008385	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
541229008386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008387	Coenzyme A binding pocket [chemical binding]; other site
541229008388	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
541229008389	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
541229008390	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
541229008391	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229008392	S-adenosylmethionine binding site [chemical binding]; other site
541229008393	Rrf2 family protein; Region: rrf2_super; TIGR00738
541229008394	Transcriptional regulator; Region: Rrf2; pfam02082
541229008395	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
541229008396	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
541229008397	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229008398	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229008399	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
541229008400	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
541229008401	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
541229008402	E3 interaction surface; other site
541229008403	lipoyl attachment site [posttranslational modification]; other site
541229008404	e3 binding domain; Region: E3_binding; pfam02817
541229008405	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
541229008406	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
541229008407	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
541229008408	alpha subunit interface [polypeptide binding]; other site
541229008409	TPP binding site [chemical binding]; other site
541229008410	heterodimer interface [polypeptide binding]; other site
541229008411	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
541229008412	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
541229008413	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
541229008414	tetramer interface [polypeptide binding]; other site
541229008415	TPP-binding site [chemical binding]; other site
541229008416	heterodimer interface [polypeptide binding]; other site
541229008417	phosphorylation loop region [posttranslational modification]
541229008418	DinB superfamily; Region: DinB_2; pfam12867
541229008419	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
541229008420	short chain dehydrogenase; Provisional; Region: PRK06914
541229008421	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
541229008422	NADP binding site [chemical binding]; other site
541229008423	active site
541229008424	steroid binding site; other site
541229008425	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
541229008426	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
541229008427	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
541229008428	nudix motif; other site
541229008429	Protein phosphatase 2C; Region: PP2C_2; pfam13672
541229008430	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
541229008431	nucleotide binding site/active site [active]
541229008432	HIT family signature motif; other site
541229008433	catalytic residue [active]
541229008434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229008435	dimer interface [polypeptide binding]; other site
541229008436	conserved gate region; other site
541229008437	putative PBP binding loops; other site
541229008438	ABC-ATPase subunit interface; other site
541229008439	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
541229008440	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
541229008441	Walker A/P-loop; other site
541229008442	ATP binding site [chemical binding]; other site
541229008443	Q-loop/lid; other site
541229008444	ABC transporter signature motif; other site
541229008445	Walker B; other site
541229008446	D-loop; other site
541229008447	H-loop/switch region; other site
541229008448	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
541229008449	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
541229008450	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
541229008451	Clp protease; Region: CLP_protease; pfam00574
541229008452	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
541229008453	oligomer interface [polypeptide binding]; other site
541229008454	active site residues [active]
541229008455	RNA polymerase factor sigma-70; Validated; Region: PRK06704
541229008456	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229008457	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
541229008458	DNA binding residues [nucleotide binding]
541229008459	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
541229008460	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
541229008461	catalytic loop [active]
541229008462	iron binding site [ion binding]; other site
541229008463	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
541229008464	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229008465	active site
541229008466	dimer interface [polypeptide binding]; other site
541229008467	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008468	Coenzyme A binding pocket [chemical binding]; other site
541229008469	Chitin binding domain; Region: Chitin_bind_3; pfam03067
541229008470	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229008471	Interdomain contacts; other site
541229008472	Cytokine receptor motif; other site
541229008473	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229008474	Interdomain contacts; other site
541229008475	Cytokine receptor motif; other site
541229008476	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
541229008477	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
541229008478	glycosyltransferase, MGT family; Region: MGT; TIGR01426
541229008479	active site
541229008480	TDP-binding site; other site
541229008481	acceptor substrate-binding pocket; other site
541229008482	homodimer interface [polypeptide binding]; other site
541229008483	Uncharacterized conserved protein [Function unknown]; Region: COG1262
541229008484	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
541229008485	topology modulation protein; Reviewed; Region: PRK08118
541229008486	AAA domain; Region: AAA_17; pfam13207
541229008487	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
541229008488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229008489	S-adenosylmethionine binding site [chemical binding]; other site
541229008490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
541229008491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008492	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229008493	Coenzyme A binding pocket [chemical binding]; other site
541229008494	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
541229008495	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
541229008496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008497	Coenzyme A binding pocket [chemical binding]; other site
541229008498	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229008499	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229008500	Protein of unknown function (DUF952); Region: DUF952; pfam06108
541229008501	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008502	Coenzyme A binding pocket [chemical binding]; other site
541229008503	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
541229008504	Part of AAA domain; Region: AAA_19; pfam13245
541229008505	Family description; Region: UvrD_C_2; pfam13538
541229008506	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
541229008507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
541229008508	HTH-like domain; Region: HTH_21; pfam13276
541229008509	Integrase core domain; Region: rve; pfam00665
541229008510	Integrase core domain; Region: rve_2; pfam13333
541229008511	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229008512	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229008513	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229008514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229008515	S-adenosylmethionine binding site [chemical binding]; other site
541229008516	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
541229008517	putative active site pocket [active]
541229008518	dimerization interface [polypeptide binding]; other site
541229008519	putative catalytic residue [active]
541229008520	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
541229008521	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229008522	ATP binding site [chemical binding]; other site
541229008523	putative Mg++ binding site [ion binding]; other site
541229008524	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229008525	nucleotide binding region [chemical binding]; other site
541229008526	ATP-binding site [chemical binding]; other site
541229008527	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
541229008528	HRDC domain; Region: HRDC; pfam00570
541229008529	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
541229008530	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
541229008531	Protein of unknown function (DUF4017); Region: DUF4017; pfam13209
541229008532	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
541229008533	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
541229008534	active site
541229008535	Zn binding site [ion binding]; other site
541229008536	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
541229008537	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
541229008538	DHHA2 domain; Region: DHHA2; pfam02833
541229008539	Chitin binding domain; Region: Chitin_bind_3; pfam03067
541229008540	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229008541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008542	Coenzyme A binding pocket [chemical binding]; other site
541229008543	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229008544	Zn2+ binding site [ion binding]; other site
541229008545	Mg2+ binding site [ion binding]; other site
541229008546	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
541229008547	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229008548	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
541229008549	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
541229008550	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
541229008551	NAD(P) binding site [chemical binding]; other site
541229008552	catalytic residues [active]
541229008553	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
541229008554	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
541229008555	inhibitor site; inhibition site
541229008556	active site
541229008557	dimer interface [polypeptide binding]; other site
541229008558	catalytic residue [active]
541229008559	Proline racemase; Region: Pro_racemase; pfam05544
541229008560	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
541229008561	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
541229008562	Proline racemase; Region: Pro_racemase; pfam05544
541229008563	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
541229008564	hydroxyglutarate oxidase; Provisional; Region: PRK11728
541229008565	PAS domain; Region: PAS_9; pfam13426
541229008566	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
541229008567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229008568	Walker A motif; other site
541229008569	ATP binding site [chemical binding]; other site
541229008570	Walker B motif; other site
541229008571	arginine finger; other site
541229008572	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
541229008573	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
541229008574	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
541229008575	catalytic loop [active]
541229008576	iron binding site [ion binding]; other site
541229008577	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
541229008578	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
541229008579	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
541229008580	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
541229008581	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229008582	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
541229008583	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229008584	Zn2+ binding site [ion binding]; other site
541229008585	Mg2+ binding site [ion binding]; other site
541229008586	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229008587	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229008588	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
541229008589	DltD N-terminal region; Region: DltD_N; pfam04915
541229008590	DltD central region; Region: DltD_M; pfam04918
541229008591	DltD C-terminal region; Region: DltD_C; pfam04914
541229008592	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008593	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229008594	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229008595	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229008596	peptide binding site [polypeptide binding]; other site
541229008597	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229008598	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229008599	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
541229008600	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
541229008601	active site
541229008602	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
541229008603	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
541229008604	Septum formation initiator; Region: DivIC; pfam04977
541229008605	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229008606	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229008607	active site
541229008608	catalytic tetrad [active]
541229008609	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
541229008610	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
541229008611	conserved cys residue [active]
541229008612	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
541229008613	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
541229008614	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
541229008615	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229008616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229008617	S-adenosylmethionine binding site [chemical binding]; other site
541229008618	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
541229008619	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229008620	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
541229008621	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
541229008622	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
541229008623	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229008624	dimerization interface [polypeptide binding]; other site
541229008625	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229008626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229008627	dimer interface [polypeptide binding]; other site
541229008628	phosphorylation site [posttranslational modification]
541229008629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229008630	ATP binding site [chemical binding]; other site
541229008631	Mg2+ binding site [ion binding]; other site
541229008632	G-X-G motif; other site
541229008633	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229008634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229008635	active site
541229008636	phosphorylation site [posttranslational modification]
541229008637	intermolecular recognition site; other site
541229008638	dimerization interface [polypeptide binding]; other site
541229008639	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229008640	DNA binding site [nucleotide binding]
541229008641	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
541229008642	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229008643	motif II; other site
541229008644	bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697
541229008645	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
541229008646	Phosphotransferase enzyme family; Region: APH; pfam01636
541229008647	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229008648	active site
541229008649	substrate binding site [chemical binding]; other site
541229008650	ATP binding site [chemical binding]; other site
541229008651	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
541229008652	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
541229008653	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
541229008654	Zn binding site [ion binding]; other site
541229008655	EDD domain protein, DegV family; Region: DegV; TIGR00762
541229008656	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
541229008657	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
541229008658	Coenzyme A binding pocket [chemical binding]; other site
541229008659	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
541229008660	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008662	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229008663	putative substrate translocation pore; other site
541229008664	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
541229008665	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
541229008666	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
541229008667	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
541229008668	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
541229008669	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
541229008670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008671	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229008672	putative substrate translocation pore; other site
541229008673	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
541229008674	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
541229008675	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
541229008676	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
541229008677	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
541229008678	active site
541229008679	Protein of unknown function (DUF3970); Region: DUF3970; pfam13113
541229008680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229008681	S-adenosylmethionine binding site [chemical binding]; other site
541229008682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008683	putative substrate translocation pore; other site
541229008684	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229008685	aspartate aminotransferase; Provisional; Region: PRK07681
541229008686	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229008687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229008688	homodimer interface [polypeptide binding]; other site
541229008689	catalytic residue [active]
541229008690	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
541229008691	pantothenate kinase; Provisional; Region: PRK13317
541229008692	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
541229008693	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
541229008694	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
541229008695	Protein of unknown function (DUF4052); Region: DUF4052; pfam13261
541229008696	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229008697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229008698	Walker A/P-loop; other site
541229008699	ATP binding site [chemical binding]; other site
541229008700	Q-loop/lid; other site
541229008701	ABC transporter signature motif; other site
541229008702	Walker B; other site
541229008703	D-loop; other site
541229008704	H-loop/switch region; other site
541229008705	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229008706	DNA-binding site [nucleotide binding]; DNA binding site
541229008707	DinB family; Region: DinB; cl17821
541229008708	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
541229008709	Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413
541229008710	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
541229008711	Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501
541229008712	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
541229008713	Domain of unknown function DUF20; Region: UPF0118; pfam01594
541229008714	HNH endonuclease; Region: HNH_5; pfam14279
541229008715	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
541229008716	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
541229008717	active site
541229008718	dimer interface [polypeptide binding]; other site
541229008719	non-prolyl cis peptide bond; other site
541229008720	insertion regions; other site
541229008721	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
541229008722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
541229008723	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
541229008724	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229008725	substrate binding pocket [chemical binding]; other site
541229008726	membrane-bound complex binding site; other site
541229008727	hinge residues; other site
541229008728	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
541229008729	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
541229008730	Walker A/P-loop; other site
541229008731	ATP binding site [chemical binding]; other site
541229008732	Q-loop/lid; other site
541229008733	ABC transporter signature motif; other site
541229008734	Walker B; other site
541229008735	D-loop; other site
541229008736	H-loop/switch region; other site
541229008737	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229008738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229008739	Protein of unknown function (DUF402); Region: DUF402; pfam04167
541229008740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
541229008741	binding surface
541229008742	TPR motif; other site
541229008743	hypothetical protein; Provisional; Region: PRK09620
541229008744	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
541229008745	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
541229008746	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
541229008747	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
541229008748	DinB superfamily; Region: DinB_2; pfam12867
541229008749	Protein of unknown function (DUF664); Region: DUF664; pfam04978
541229008750	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
541229008751	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008752	Coenzyme A binding pocket [chemical binding]; other site
541229008753	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008754	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229008755	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
541229008756	active site
541229008757	NTP binding site [chemical binding]; other site
541229008758	metal binding triad [ion binding]; metal-binding site
541229008759	antibiotic binding site [chemical binding]; other site
541229008760	A new structural DNA glycosylase; Region: AlkD_like; cl11434
541229008761	active site
541229008762	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
541229008763	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229008764	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
541229008765	catalytic residue [active]
541229008766	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229008767	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
541229008768	active site
541229008769	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229008770	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
541229008771	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
541229008772	conserved cys residue [active]
541229008773	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229008774	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
541229008775	NodB motif; other site
541229008776	active site
541229008777	catalytic site [active]
541229008778	Zn binding site [ion binding]; other site
541229008779	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
541229008780	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
541229008781	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
541229008782	Sulfatase; Region: Sulfatase; pfam00884
541229008783	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
541229008784	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229008785	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229008786	ABC transporter; Region: ABC_tran_2; pfam12848
541229008787	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229008788	MMPL family; Region: MMPL; pfam03176
541229008789	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
541229008790	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229008791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229008792	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
541229008793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008794	Coenzyme A binding pocket [chemical binding]; other site
541229008795	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
541229008796	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
541229008797	hinge; other site
541229008798	active site
541229008799	prephenate dehydrogenase; Validated; Region: PRK06545
541229008800	prephenate dehydrogenase; Validated; Region: PRK08507
541229008801	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
541229008802	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
541229008803	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229008804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229008805	homodimer interface [polypeptide binding]; other site
541229008806	catalytic residue [active]
541229008807	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
541229008808	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
541229008809	Tetramer interface [polypeptide binding]; other site
541229008810	active site
541229008811	FMN-binding site [chemical binding]; other site
541229008812	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
541229008813	Chorismate mutase type II; Region: CM_2; cl00693
541229008814	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
541229008815	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
541229008816	Domain of unknown function (DUF4020); Region: DUF4020; pfam13212
541229008817	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
541229008818	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
541229008819	Isochorismatase family; Region: Isochorismatase; pfam00857
541229008820	catalytic triad [active]
541229008821	conserved cis-peptide bond; other site
541229008822	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229008824	Coenzyme A binding pocket [chemical binding]; other site
541229008825	YfzA-like protein; Region: YfzA; pfam14118
541229008826	hypothetical protein; Provisional; Region: PRK06762
541229008827	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
541229008828	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229008829	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229008830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
541229008831	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
541229008832	FAD binding domain; Region: FAD_binding_4; pfam01565
541229008833	Berberine and berberine like; Region: BBE; pfam08031
541229008834	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
541229008835	malate:quinone oxidoreductase; Validated; Region: PRK05257
541229008836	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
541229008837	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
541229008838	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
541229008839	ligand binding site [chemical binding]; other site
541229008840	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
541229008841	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
541229008842	TM-ABC transporter signature motif; other site
541229008843	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
541229008844	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
541229008845	TM-ABC transporter signature motif; other site
541229008846	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
541229008847	ABC transporter signature motif; other site
541229008848	Walker B; other site
541229008849	D-loop; other site
541229008850	H-loop/switch region; other site
541229008851	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
541229008852	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
541229008853	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
541229008854	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
541229008855	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
541229008856	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
541229008857	putative N- and C-terminal domain interface [polypeptide binding]; other site
541229008858	putative active site [active]
541229008859	putative MgATP binding site [chemical binding]; other site
541229008860	catalytic site [active]
541229008861	metal binding site [ion binding]; metal-binding site
541229008862	putative carbohydrate binding site [chemical binding]; other site
541229008863	Cupin domain; Region: Cupin_2; pfam07883
541229008864	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
541229008865	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
541229008866	putative active site; other site
541229008867	catalytic residue [active]
541229008868	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229008869	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
541229008870	active site
541229008871	metal binding site [ion binding]; metal-binding site
541229008872	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
541229008873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008874	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229008875	putative substrate translocation pore; other site
541229008876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229008877	putative DNA binding site [nucleotide binding]; other site
541229008878	putative Zn2+ binding site [ion binding]; other site
541229008879	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229008880	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229008881	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229008882	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
541229008883	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
541229008884	putative catalytic cysteine [active]
541229008885	gamma-glutamyl kinase; Provisional; Region: PRK05429
541229008886	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
541229008887	nucleotide binding site [chemical binding]; other site
541229008888	homotetrameric interface [polypeptide binding]; other site
541229008889	putative phosphate binding site [ion binding]; other site
541229008890	putative allosteric binding site; other site
541229008891	PUA domain; Region: PUA; pfam01472
541229008892	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
541229008893	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
541229008894	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
541229008895	M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654
541229008896	putative metal binding site [ion binding]; other site
541229008897	putative dimer interface [polypeptide binding]; other site
541229008898	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
541229008899	Transcriptional regulator [Transcription]; Region: IclR; COG1414
541229008900	Bacterial transcriptional regulator; Region: IclR; pfam01614
541229008901	S-methylmethionine transporter; Provisional; Region: PRK11387
541229008902	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
541229008903	active site
541229008904	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229008905	active site
541229008906	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229008907	MarR family; Region: MarR_2; pfam12802
541229008908	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
541229008909	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
541229008910	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
541229008911	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
541229008912	putative di-iron ligands [ion binding]; other site
541229008913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
541229008914	Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547
541229008915	VanW like protein; Region: VanW; pfam04294
541229008916	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
541229008917	dimer interface [polypeptide binding]; other site
541229008918	Alkaline phosphatase homologues; Region: alkPPc; smart00098
541229008919	active site
541229008920	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
541229008921	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229008922	salt bridge; other site
541229008923	non-specific DNA binding site [nucleotide binding]; other site
541229008924	sequence-specific DNA binding site [nucleotide binding]; other site
541229008925	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
541229008926	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229008927	motif II; other site
541229008928	uridine kinase; Provisional; Region: PRK07667
541229008929	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229008930	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229008931	Coenzyme A binding pocket [chemical binding]; other site
541229008932	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229008933	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
541229008934	active site
541229008935	metal binding site [ion binding]; metal-binding site
541229008936	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
541229008937	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229008938	Transcriptional regulator PadR-like family; Region: PadR; cl17335
541229008939	MoxR-like ATPases [General function prediction only]; Region: COG0714
541229008940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229008941	Walker A motif; other site
541229008942	ATP binding site [chemical binding]; other site
541229008943	Walker B motif; other site
541229008944	arginine finger; other site
541229008945	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
541229008946	Protein of unknown function DUF58; Region: DUF58; pfam01882
541229008947	Domain of unknown function (DUF4018); Region: DUF4018; pfam13210
541229008948	proline/glycine betaine transporter; Provisional; Region: PRK10642
541229008949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229008950	putative substrate translocation pore; other site
541229008951	acetylornithine aminotransferase; Provisional; Region: PRK02627
541229008952	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229008953	inhibitor-cofactor binding pocket; inhibition site
541229008954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229008955	catalytic residue [active]
541229008956	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
541229008957	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
541229008958	tetramer interface [polypeptide binding]; other site
541229008959	heme binding pocket [chemical binding]; other site
541229008960	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
541229008961	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
541229008962	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
541229008963	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
541229008964	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
541229008965	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
541229008966	active site
541229008967	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
541229008968	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229008969	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229008970	Protein of unknown function (DUF3902); Region: DUF3902; pfam13042
541229008971	Uncharacterized conserved protein [Function unknown]; Region: COG1359
541229008972	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
541229008973	dimer interface [polypeptide binding]; other site
541229008974	FMN binding site [chemical binding]; other site
541229008975	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229008976	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229008977	putative DNA binding site [nucleotide binding]; other site
541229008978	putative Zn2+ binding site [ion binding]; other site
541229008979	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
541229008980	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
541229008981	G1 box; other site
541229008982	putative GEF interaction site [polypeptide binding]; other site
541229008983	GTP/Mg2+ binding site [chemical binding]; other site
541229008984	Switch I region; other site
541229008985	G2 box; other site
541229008986	G3 box; other site
541229008987	Switch II region; other site
541229008988	G4 box; other site
541229008989	G5 box; other site
541229008990	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
541229008991	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
541229008992	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
541229008993	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
541229008994	nudix motif; other site
541229008995	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
541229008996	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
541229008997	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
541229008998	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
541229008999	putative NAD(P) binding site [chemical binding]; other site
541229009000	active site
541229009001	transposase/IS protein; Provisional; Region: PRK09183
541229009002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229009003	Walker A motif; other site
541229009004	ATP binding site [chemical binding]; other site
541229009005	Walker B motif; other site
541229009006	arginine finger; other site
541229009007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229009008	Integrase core domain; Region: rve; pfam00665
541229009009	CAAX protease self-immunity; Region: Abi; pfam02517
541229009010	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009011	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009012	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
541229009013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229009014	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
541229009015	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229009016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009017	Coenzyme A binding pocket [chemical binding]; other site
541229009018	Domain of unknown function (DUF3980); Region: DUF3980; pfam13140
541229009019	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
541229009020	nudix motif; other site
541229009021	EamA-like transporter family; Region: EamA; pfam00892
541229009022	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229009023	EamA-like transporter family; Region: EamA; pfam00892
541229009024	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229009025	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229009026	DNA-binding site [nucleotide binding]; DNA binding site
541229009027	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229009028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229009029	homodimer interface [polypeptide binding]; other site
541229009030	catalytic residue [active]
541229009031	hypothetical protein; Validated; Region: PRK00124
541229009032	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
541229009033	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
541229009034	uridine kinase; Validated; Region: PRK06696
541229009035	AAA domain; Region: AAA_18; pfam13238
541229009036	active site
541229009037	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
541229009038	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229009039	active site
541229009040	metal binding site [ion binding]; metal-binding site
541229009041	Phosphotransferase enzyme family; Region: APH; pfam01636
541229009042	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
541229009043	active site
541229009044	ATP binding site [chemical binding]; other site
541229009045	substrate binding site [chemical binding]; other site
541229009046	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
541229009047	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229009048	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229009049	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229009050	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229009051	Coenzyme A binding pocket [chemical binding]; other site
541229009052	lysine transporter; Provisional; Region: PRK10836
541229009053	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
541229009054	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
541229009055	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229009056	HAMP domain; Region: HAMP; pfam00672
541229009057	dimerization interface [polypeptide binding]; other site
541229009058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229009059	dimer interface [polypeptide binding]; other site
541229009060	phosphorylation site [posttranslational modification]
541229009061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229009062	ATP binding site [chemical binding]; other site
541229009063	Mg2+ binding site [ion binding]; other site
541229009064	G-X-G motif; other site
541229009065	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229009066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229009067	active site
541229009068	phosphorylation site [posttranslational modification]
541229009069	intermolecular recognition site; other site
541229009070	dimerization interface [polypeptide binding]; other site
541229009071	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229009072	DNA binding site [nucleotide binding]
541229009073	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
541229009074	FtsX-like permease family; Region: FtsX; pfam02687
541229009075	FtsX-like permease family; Region: FtsX; pfam02687
541229009076	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229009077	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229009078	Walker A/P-loop; other site
541229009079	ATP binding site [chemical binding]; other site
541229009080	Q-loop/lid; other site
541229009081	ABC transporter signature motif; other site
541229009082	Walker B; other site
541229009083	D-loop; other site
541229009084	H-loop/switch region; other site
541229009085	hypothetical protein; Provisional; Region: PRK06760; cl11698
541229009086	Methyltransferase domain; Region: Methyltransf_11; pfam08241
541229009087	S-adenosylmethionine binding site [chemical binding]; other site
541229009088	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
541229009089	putative active site [active]
541229009090	nucleotide binding site [chemical binding]; other site
541229009091	nudix motif; other site
541229009092	putative metal binding site [ion binding]; other site
541229009093	Cephalosporin hydroxylase; Region: CmcI; pfam04989
541229009094	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
541229009095	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229009096	Catalytic site [active]
541229009097	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229009098	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229009099	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229009100	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229009101	NAD-dependent deacetylase; Provisional; Region: PRK00481
541229009102	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
541229009103	NAD+ binding site [chemical binding]; other site
541229009104	substrate binding site [chemical binding]; other site
541229009105	Zn binding site [ion binding]; other site
541229009106	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
541229009107	putative substrate binding pocket [chemical binding]; other site
541229009108	AC domain interface; other site
541229009109	catalytic triad [active]
541229009110	AB domain interface; other site
541229009111	interchain disulfide; other site
541229009112	Predicted membrane protein [Function unknown]; Region: COG3817
541229009113	Protein of unknown function (DUF979); Region: DUF979; pfam06166
541229009114	Protein of unknown function (DUF969); Region: DUF969; pfam06149
541229009115	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
541229009116	putative active site [active]
541229009117	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
541229009118	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
541229009119	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
541229009120	Transcriptional regulator [Transcription]; Region: IclR; COG1414
541229009121	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
541229009122	Bacterial transcriptional regulator; Region: IclR; pfam01614
541229009123	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
541229009124	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
541229009125	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229009126	Catalytic site [active]
541229009127	CutC family; Region: CutC; cl01218
541229009128	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009129	putative DNA binding site [nucleotide binding]; other site
541229009130	putative Zn2+ binding site [ion binding]; other site
541229009131	DinB superfamily; Region: DinB_2; pfam12867
541229009132	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
541229009133	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
541229009134	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
541229009135	Uncharacterized conserved protein [Function unknown]; Region: COG1434
541229009136	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
541229009137	putative active site [active]
541229009138	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229009139	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229009140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
541229009141	Nucleoside recognition; Region: Gate; pfam07670
541229009142	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
541229009143	Phosphotransferase enzyme family; Region: APH; pfam01636
541229009144	putative active site [active]
541229009145	putative substrate binding site [chemical binding]; other site
541229009146	ATP binding site [chemical binding]; other site
541229009147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009148	Coenzyme A binding pocket [chemical binding]; other site
541229009149	Protein of unknown function (DUF2691); Region: DUF2691; pfam10903
541229009150	Uncharacterized conserved protein [Function unknown]; Region: COG1633
541229009151	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
541229009152	dinuclear metal binding motif [ion binding]; other site
541229009153	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229009154	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229009155	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
541229009156	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
541229009157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229009158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229009159	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
541229009160	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
541229009161	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009162	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009163	Erythromycin esterase; Region: Erythro_esteras; pfam05139
541229009164	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
541229009165	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
541229009166	putative active site [active]
541229009167	putative metal binding site [ion binding]; other site
541229009168	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
541229009169	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229009170	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229009171	TAP-like protein; Region: Abhydrolase_4; pfam08386
541229009172	Isochorismatase family; Region: Isochorismatase; pfam00857
541229009173	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
541229009174	catalytic triad [active]
541229009175	dimer interface [polypeptide binding]; other site
541229009176	conserved cis-peptide bond; other site
541229009177	Isochorismatase family; Region: Isochorismatase; pfam00857
541229009178	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
541229009179	catalytic triad [active]
541229009180	dimer interface [polypeptide binding]; other site
541229009181	conserved cis-peptide bond; other site
541229009182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
541229009183	Amidohydrolase family; Region: Amidohydro_3; pfam07969
541229009184	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
541229009185	active site
541229009186	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229009187	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229009188	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229009189	dimerization interface [polypeptide binding]; other site
541229009190	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229009191	MarR family; Region: MarR; pfam01047
541229009192	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
541229009193	Cl binding site [ion binding]; other site
541229009194	oligomer interface [polypeptide binding]; other site
541229009195	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
541229009196	plasmid segregation protein ParM; Provisional; Region: PRK13917
541229009197	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
541229009198	Mg binding site [ion binding]; other site
541229009199	nucleotide binding site [chemical binding]; other site
541229009200	putative protofilament interface [polypeptide binding]; other site
541229009201	Heat induced stress protein YflT; Region: YflT; pfam11181
541229009202	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229009203	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
541229009204	Spore germination protein; Region: Spore_permease; cl17796
541229009205	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
541229009206	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
541229009207	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
541229009208	TspO/MBR family; Region: TspO_MBR; pfam03073
541229009209	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
541229009210	DNA photolyase; Region: DNA_photolyase; pfam00875
541229009211	Adenoviral protein L1 52/55-kDa; Region: Adeno_52K; pfam03052
541229009212	Carbonic anhydrase; Region: Pro_CA; pfam00484
541229009213	zinc binding site [ion binding]; other site
541229009214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
541229009215	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
541229009216	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
541229009217	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
541229009218	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
541229009219	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229009220	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
541229009221	NodB motif; other site
541229009222	active site
541229009223	catalytic site [active]
541229009224	Zn binding site [ion binding]; other site
541229009225	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229009226	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009227	Coenzyme A binding pocket [chemical binding]; other site
541229009228	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
541229009229	UbiA prenyltransferase family; Region: UbiA; pfam01040
541229009230	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
541229009231	Low molecular weight phosphatase family; Region: LMWPc; cd00115
541229009232	active site
541229009233	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
541229009234	arsenical-resistance protein; Region: acr3; TIGR00832
541229009235	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229009236	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
541229009237	putative metal binding site [ion binding]; other site
541229009238	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009239	dimerization interface [polypeptide binding]; other site
541229009240	putative DNA binding site [nucleotide binding]; other site
541229009241	putative Zn2+ binding site [ion binding]; other site
541229009242	DinB superfamily; Region: DinB_2; pfam12867
541229009243	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
541229009244	RibD C-terminal domain; Region: RibD_C; cl17279
541229009245	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
541229009246	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
541229009247	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
541229009248	putative NAD(P) binding site [chemical binding]; other site
541229009249	active site
541229009250	putative substrate binding site [chemical binding]; other site
541229009251	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229009252	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229009253	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229009254	Protein of unknown function (DUF3914); Region: DUF3914; pfam13053
541229009255	CAAX protease self-immunity; Region: Abi; pfam02517
541229009256	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229009257	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009258	Coenzyme A binding pocket [chemical binding]; other site
541229009259	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
541229009260	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229009261	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229009262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009263	putative substrate translocation pore; other site
541229009264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229009265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229009266	short chain dehydrogenase; Provisional; Region: PRK12746
541229009267	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
541229009268	NADP binding site [chemical binding]; other site
541229009269	homodimer interface [polypeptide binding]; other site
541229009270	active site
541229009271	substrate binding site [chemical binding]; other site
541229009272	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
541229009273	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009274	putative DNA binding site [nucleotide binding]; other site
541229009275	putative Zn2+ binding site [ion binding]; other site
541229009276	AsnC family; Region: AsnC_trans_reg; pfam01037
541229009277	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
541229009278	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
541229009279	metal binding site [ion binding]; metal-binding site
541229009280	AAA domain; Region: AAA_11; pfam13086
541229009281	Part of AAA domain; Region: AAA_19; pfam13245
541229009282	Erp protein C-terminus; Region: Erp_C; pfam06780
541229009283	AAA domain; Region: AAA_30; pfam13604
541229009284	AAA domain; Region: AAA_12; pfam13087
541229009285	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
541229009286	putative active site [active]
541229009287	catalytic site [active]
541229009288	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229009289	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
541229009290	active site
541229009291	metal binding site [ion binding]; metal-binding site
541229009292	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
541229009293	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
541229009294	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009295	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009296	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009297	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009298	putative monooxygenase; Provisional; Region: PRK11118
541229009299	DoxX-like family; Region: DoxX_2; pfam13564
541229009300	Transcriptional regulators [Transcription]; Region: MarR; COG1846
541229009301	MarR family; Region: MarR_2; pfam12802
541229009302	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
541229009303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229009304	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229009305	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229009306	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
541229009307	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
541229009308	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
541229009309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229009310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229009311	active site
541229009312	phosphorylation site [posttranslational modification]
541229009313	intermolecular recognition site; other site
541229009314	dimerization interface [polypeptide binding]; other site
541229009315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229009316	DNA binding site [nucleotide binding]
541229009317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229009318	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229009319	dimerization interface [polypeptide binding]; other site
541229009320	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229009321	dimer interface [polypeptide binding]; other site
541229009322	phosphorylation site [posttranslational modification]
541229009323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229009324	ATP binding site [chemical binding]; other site
541229009325	G-X-G motif; other site
541229009326	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
541229009327	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
541229009328	CAAX protease self-immunity; Region: Abi; pfam02517
541229009329	Putative sensor; Region: Sensor; pfam13796
541229009330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229009331	Histidine kinase; Region: HisKA_3; pfam07730
541229009332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229009333	ATP binding site [chemical binding]; other site
541229009334	Mg2+ binding site [ion binding]; other site
541229009335	G-X-G motif; other site
541229009336	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229009337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229009338	active site
541229009339	phosphorylation site [posttranslational modification]
541229009340	intermolecular recognition site; other site
541229009341	dimerization interface [polypeptide binding]; other site
541229009342	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229009343	DNA binding residues [nucleotide binding]
541229009344	dimerization interface [polypeptide binding]; other site
541229009345	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229009346	FtsX-like permease family; Region: FtsX; pfam02687
541229009347	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229009348	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229009349	Walker A/P-loop; other site
541229009350	ATP binding site [chemical binding]; other site
541229009351	Q-loop/lid; other site
541229009352	ABC transporter signature motif; other site
541229009353	Walker B; other site
541229009354	D-loop; other site
541229009355	H-loop/switch region; other site
541229009356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229009357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229009358	dimer interface [polypeptide binding]; other site
541229009359	phosphorylation site [posttranslational modification]
541229009360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229009361	ATP binding site [chemical binding]; other site
541229009362	Mg2+ binding site [ion binding]; other site
541229009363	G-X-G motif; other site
541229009364	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229009365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229009366	active site
541229009367	phosphorylation site [posttranslational modification]
541229009368	intermolecular recognition site; other site
541229009369	dimerization interface [polypeptide binding]; other site
541229009370	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229009371	DNA binding site [nucleotide binding]
541229009372	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
541229009373	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565
541229009374	putative metal binding site [ion binding]; other site
541229009375	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
541229009376	Cytochrome P450; Region: p450; pfam00067
541229009377	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
541229009378	Flavodoxin; Region: Flavodoxin_1; pfam00258
541229009379	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
541229009380	FAD binding pocket [chemical binding]; other site
541229009381	FAD binding motif [chemical binding]; other site
541229009382	catalytic residues [active]
541229009383	NAD binding pocket [chemical binding]; other site
541229009384	phosphate binding motif [ion binding]; other site
541229009385	beta-alpha-beta structure motif; other site
541229009386	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
541229009387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009388	putative substrate translocation pore; other site
541229009389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009390	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
541229009391	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
541229009392	D-cysteine desulfhydrase; Validated; Region: PRK03910
541229009393	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
541229009394	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229009395	catalytic residue [active]
541229009396	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
541229009397	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229009398	active site
541229009399	metal binding site [ion binding]; metal-binding site
541229009400	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
541229009401	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
541229009402	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
541229009403	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
541229009404	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
541229009405	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
541229009406	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
541229009407	hypothetical protein; Provisional; Region: PRK06762
541229009408	AAA domain; Region: AAA_33; pfam13671
541229009409	Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702
541229009410	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
541229009411	FAD binding domain; Region: FAD_binding_4; pfam01565
541229009412	Berberine and berberine like; Region: BBE; pfam08031
541229009413	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229009414	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229009415	Walker A/P-loop; other site
541229009416	ATP binding site [chemical binding]; other site
541229009417	Q-loop/lid; other site
541229009418	ABC transporter signature motif; other site
541229009419	Walker B; other site
541229009420	D-loop; other site
541229009421	H-loop/switch region; other site
541229009422	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
541229009423	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229009424	FtsX-like permease family; Region: FtsX; pfam02687
541229009425	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009426	dimerization interface [polypeptide binding]; other site
541229009427	putative DNA binding site [nucleotide binding]; other site
541229009428	Predicted transcriptional regulator [Transcription]; Region: COG2345
541229009429	putative Zn2+ binding site [ion binding]; other site
541229009430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009431	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229009432	putative substrate translocation pore; other site
541229009433	DinB superfamily; Region: DinB_2; pfam12867
541229009434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229009435	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229009436	dimerization interface [polypeptide binding]; other site
541229009437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229009438	dimer interface [polypeptide binding]; other site
541229009439	phosphorylation site [posttranslational modification]
541229009440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229009441	ATP binding site [chemical binding]; other site
541229009442	Mg2+ binding site [ion binding]; other site
541229009443	G-X-G motif; other site
541229009444	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229009445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229009446	active site
541229009447	phosphorylation site [posttranslational modification]
541229009448	intermolecular recognition site; other site
541229009449	dimerization interface [polypeptide binding]; other site
541229009450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229009451	DNA binding site [nucleotide binding]
541229009452	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229009453	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229009454	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229009455	2TM domain; Region: 2TM; pfam13239
541229009456	F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763
541229009457	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
541229009458	putative dimer interface [polypeptide binding]; other site
541229009459	catalytic triad [active]
541229009460	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
541229009461	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
541229009462	dimer interaction site [polypeptide binding]; other site
541229009463	substrate-binding tunnel; other site
541229009464	active site
541229009465	catalytic site [active]
541229009466	substrate binding site [chemical binding]; other site
541229009467	Uncharacterized conserved protein [Function unknown]; Region: COG4198
541229009468	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
541229009469	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
541229009470	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
541229009471	putative ligand binding site [chemical binding]; other site
541229009472	putative NAD binding site [chemical binding]; other site
541229009473	putative catalytic site [active]
541229009474	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
541229009475	L-serine binding site [chemical binding]; other site
541229009476	ACT domain interface; other site
541229009477	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
541229009478	homodimer interface [polypeptide binding]; other site
541229009479	substrate-cofactor binding pocket; other site
541229009480	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229009481	catalytic residue [active]
541229009482	Domain of unknown function (DUF378); Region: DUF378; cl00943
541229009483	Cupin domain; Region: Cupin_2; cl17218
541229009484	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
541229009485	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229009486	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
541229009487	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
541229009488	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
541229009489	active site
541229009490	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815
541229009491	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229009492	substrate binding site [chemical binding]; other site
541229009493	amidase catalytic site [active]
541229009494	Zn binding residues [ion binding]; other site
541229009495	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229009496	S-layer homology domain; Region: SLH; pfam00395
541229009497	S-layer homology domain; Region: SLH; pfam00395
541229009498	S-layer homology domain; Region: SLH; pfam00395
541229009499	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
541229009500	A new structural DNA glycosylase; Region: AlkD_like; cd06561
541229009501	active site
541229009502	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
541229009503	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
541229009504	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
541229009505	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
541229009506	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
541229009507	putative active site [active]
541229009508	putative metal binding site [ion binding]; other site
541229009509	NETI protein; Region: NETI; pfam14044
541229009510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229009512	putative substrate translocation pore; other site
541229009513	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229009514	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229009515	TAP-like protein; Region: Abhydrolase_4; pfam08386
541229009516	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229009517	MarR family; Region: MarR_2; pfam12802
541229009518	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229009519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009520	putative substrate translocation pore; other site
541229009521	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009522	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009523	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009524	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009525	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
541229009526	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
541229009527	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
541229009528	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229009529	SWIM zinc finger; Region: SWIM; pfam04434
541229009530	YwiC-like protein; Region: YwiC; pfam14256
541229009531	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
541229009532	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229009533	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
541229009534	Walker A/P-loop; other site
541229009535	ATP binding site [chemical binding]; other site
541229009536	Q-loop/lid; other site
541229009537	ABC transporter signature motif; other site
541229009538	Walker B; other site
541229009539	D-loop; other site
541229009540	H-loop/switch region; other site
541229009541	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229009542	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
541229009543	Walker A/P-loop; other site
541229009544	ATP binding site [chemical binding]; other site
541229009545	Q-loop/lid; other site
541229009546	ABC transporter signature motif; other site
541229009547	Walker B; other site
541229009548	D-loop; other site
541229009549	H-loop/switch region; other site
541229009550	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
541229009551	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
541229009552	Predicted membrane protein [Function unknown]; Region: COG1288
541229009553	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
541229009554	Endonuclease I; Region: Endonuclease_1; pfam04231
541229009555	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
541229009556	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
541229009557	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229009558	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
541229009559	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229009560	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229009561	non-specific DNA binding site [nucleotide binding]; other site
541229009562	salt bridge; other site
541229009563	sequence-specific DNA binding site [nucleotide binding]; other site
541229009564	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
541229009565	putative deacylase active site [active]
541229009566	histidyl-tRNA synthetase; Provisional; Region: PRK12420
541229009567	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
541229009568	dimer interface [polypeptide binding]; other site
541229009569	motif 1; other site
541229009570	active site
541229009571	motif 2; other site
541229009572	motif 3; other site
541229009573	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
541229009574	anticodon binding site; other site
541229009575	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229009576	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
541229009577	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
541229009578	dimer interface [polypeptide binding]; other site
541229009579	FMN binding site [chemical binding]; other site
541229009580	pyruvate kinase; Validated; Region: PRK06739
541229009581	active site
541229009582	domain interfaces; other site
541229009583	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
541229009584	classical (c) SDRs; Region: SDR_c; cd05233
541229009585	NAD(P) binding site [chemical binding]; other site
541229009586	active site
541229009587	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
541229009588	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229009589	Walker A/P-loop; other site
541229009590	ATP binding site [chemical binding]; other site
541229009591	Q-loop/lid; other site
541229009592	ABC transporter signature motif; other site
541229009593	Walker B; other site
541229009594	D-loop; other site
541229009595	H-loop/switch region; other site
541229009596	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229009597	sequence-specific DNA binding site [nucleotide binding]; other site
541229009598	salt bridge; other site
541229009599	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
541229009600	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229009601	motif II; other site
541229009602	Phosphotransferase enzyme family; Region: APH; pfam01636
541229009603	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229009604	active site
541229009605	ATP binding site [chemical binding]; other site
541229009606	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
541229009607	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
541229009608	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229009609	Coenzyme A binding pocket [chemical binding]; other site
541229009610	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
541229009611	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
541229009612	nudix motif; other site
541229009613	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
541229009614	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
541229009615	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229009616	putative metal binding site [ion binding]; other site
541229009617	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
541229009618	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
541229009619	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
541229009620	Probable transposase; Region: OrfB_IS605; pfam01385
541229009621	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229009622	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
541229009623	maltose O-acetyltransferase; Provisional; Region: PRK10092
541229009624	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
541229009625	active site
541229009626	substrate binding site [chemical binding]; other site
541229009627	trimer interface [polypeptide binding]; other site
541229009628	CoA binding site [chemical binding]; other site
541229009629	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
541229009630	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
541229009631	active site
541229009632	HIGH motif; other site
541229009633	dimer interface [polypeptide binding]; other site
541229009634	KMSKS motif; other site
541229009635	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464
541229009636	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
541229009637	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
541229009638	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
541229009639	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
541229009640	Domain of unknown function DUF20; Region: UPF0118; pfam01594
541229009641	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
541229009642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009643	Coenzyme A binding pocket [chemical binding]; other site
541229009644	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229009645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229009646	S-adenosylmethionine binding site [chemical binding]; other site
541229009647	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
541229009648	CGNR zinc finger; Region: zf-CGNR; pfam11706
541229009649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009650	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229009651	putative substrate translocation pore; other site
541229009652	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
541229009653	hypothetical protein; Provisional; Region: PRK04164
541229009654	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229009655	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
541229009656	Domain of unknown function DUF21; Region: DUF21; pfam01595
541229009657	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
541229009658	Transporter associated domain; Region: CorC_HlyC; smart01091
541229009659	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
541229009660	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
541229009661	DNA binding residues [nucleotide binding]
541229009662	putative dimer interface [polypeptide binding]; other site
541229009663	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
541229009664	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
541229009665	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
541229009666	substrate binding site; other site
541229009667	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
541229009668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229009669	NAD(P) binding site [chemical binding]; other site
541229009670	active site
541229009671	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
541229009672	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229009673	Methyltransferase domain; Region: Methyltransf_12; pfam08242
541229009674	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
541229009675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229009676	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
541229009677	NAD(P) binding site [chemical binding]; other site
541229009678	active site
541229009679	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
541229009680	Src Homology 3 domain superfamily; Region: SH3; cl17036
541229009681	EamA-like transporter family; Region: EamA; pfam00892
541229009682	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229009683	EamA-like transporter family; Region: EamA; pfam00892
541229009684	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
541229009685	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
541229009686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
541229009687	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
541229009688	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
541229009689	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
541229009690	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
541229009691	N- and C-terminal domain interface [polypeptide binding]; other site
541229009692	active site
541229009693	catalytic site [active]
541229009694	metal binding site [ion binding]; metal-binding site
541229009695	carbohydrate binding site [chemical binding]; other site
541229009696	ATP binding site [chemical binding]; other site
541229009697	GntP family permease; Region: GntP_permease; pfam02447
541229009698	fructuronate transporter; Provisional; Region: PRK10034; cl15264
541229009699	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
541229009700	active site
541229009701	intersubunit interactions; other site
541229009702	catalytic residue [active]
541229009703	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
541229009704	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
541229009705	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
541229009706	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
541229009707	TPP-binding site [chemical binding]; other site
541229009708	dimer interface [polypeptide binding]; other site
541229009709	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
541229009710	PYR/PP interface [polypeptide binding]; other site
541229009711	dimer interface [polypeptide binding]; other site
541229009712	TPP binding site [chemical binding]; other site
541229009713	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
541229009714	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
541229009715	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
541229009716	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
541229009717	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229009718	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
541229009719	putative NAD(P) binding site [chemical binding]; other site
541229009720	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
541229009721	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
541229009722	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
541229009723	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229009724	putative NAD(P) binding site [chemical binding]; other site
541229009725	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
541229009726	classical (c) SDRs; Region: SDR_c; cd05233
541229009727	NAD(P) binding site [chemical binding]; other site
541229009728	active site
541229009729	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229009730	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229009731	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
541229009732	active site
541229009733	Zn binding site [ion binding]; other site
541229009734	Viral enhancin protein; Region: Enhancin; pfam03272
541229009735	Peptidase M60-like family; Region: M60-like; pfam13402
541229009736	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
541229009737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229009738	dimerization interface [polypeptide binding]; other site
541229009739	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229009740	dimer interface [polypeptide binding]; other site
541229009741	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
541229009742	putative CheW interface [polypeptide binding]; other site
541229009743	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
541229009744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229009745	motif II; other site
541229009746	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
541229009747	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
541229009748	catalytic motif [active]
541229009749	Zn binding site [ion binding]; other site
541229009750	RibD C-terminal domain; Region: RibD_C; cl17279
541229009751	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
541229009752	dimerization interface [polypeptide binding]; other site
541229009753	active site
541229009754	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229009755	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
541229009756	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
541229009757	dimer interface [polypeptide binding]; other site
541229009758	FMN binding site [chemical binding]; other site
541229009759	BNR repeat-like domain; Region: BNR_2; pfam13088
541229009760	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229009761	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229009762	active site
541229009763	catalytic tetrad [active]
541229009764	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229009765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009766	putative substrate translocation pore; other site
541229009767	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
541229009768	active site 1 [active]
541229009769	dimer interface [polypeptide binding]; other site
541229009770	hexamer interface [polypeptide binding]; other site
541229009771	active site 2 [active]
541229009772	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
541229009773	hexamer interface [polypeptide binding]; other site
541229009774	active site 2 [active]
541229009775	hypothetical protein; Provisional; Region: PRK02487
541229009776	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
541229009777	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
541229009778	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
541229009779	PhnA protein; Region: PhnA; pfam03831
541229009780	putative transporter; Provisional; Region: PRK11660
541229009781	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
541229009782	Sulfate transporter family; Region: Sulfate_transp; pfam00916
541229009783	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
541229009784	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009785	dimerization interface [polypeptide binding]; other site
541229009786	putative DNA binding site [nucleotide binding]; other site
541229009787	putative Zn2+ binding site [ion binding]; other site
541229009788	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
541229009789	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
541229009790	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
541229009791	IDEAL domain; Region: IDEAL; pfam08858
541229009792	Transcriptional regulator; Region: Rrf2; pfam02082
541229009793	Rrf2 family protein; Region: rrf2_super; TIGR00738
541229009794	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
541229009795	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
541229009796	ArsC family; Region: ArsC; pfam03960
541229009797	putative catalytic residues [active]
541229009798	thiol/disulfide switch; other site
541229009799	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229009800	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009801	dimerization interface [polypeptide binding]; other site
541229009802	putative DNA binding site [nucleotide binding]; other site
541229009803	putative Zn2+ binding site [ion binding]; other site
541229009804	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
541229009805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229009806	DNA-binding site [nucleotide binding]; DNA binding site
541229009807	UTRA domain; Region: UTRA; pfam07702
541229009808	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229009809	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229009810	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229009811	putative oxidoreductase; Provisional; Region: PRK10206
541229009812	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
541229009813	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
541229009814	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
541229009815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
541229009816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229009817	S-adenosylmethionine binding site [chemical binding]; other site
541229009818	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229009819	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
541229009820	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229009821	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009822	dimerization interface [polypeptide binding]; other site
541229009823	putative DNA binding site [nucleotide binding]; other site
541229009824	putative Zn2+ binding site [ion binding]; other site
541229009825	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229009826	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229009827	active site
541229009828	catalytic tetrad [active]
541229009829	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
541229009830	putative hydrophobic ligand binding site [chemical binding]; other site
541229009831	protein interface [polypeptide binding]; other site
541229009832	gate; other site
541229009833	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
541229009834	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
541229009835	putative active site [active]
541229009836	putative catalytic triad [active]
541229009837	Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838
541229009838	catalytic triad [active]
541229009839	oxyanion hole [active]
541229009840	active site
541229009841	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229009842	Phosphotransferase enzyme family; Region: APH; pfam01636
541229009843	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
541229009844	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
541229009845	Uncharacterized conserved protein [Function unknown]; Region: COG0327
541229009846	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
541229009847	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
541229009848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009849	Coenzyme A binding pocket [chemical binding]; other site
541229009850	C factor cell-cell signaling protein; Provisional; Region: PRK09009
541229009851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229009852	NAD(P) binding site [chemical binding]; other site
541229009853	active site
541229009854	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229009855	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229009856	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
541229009857	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
541229009858	acyl-activating enzyme (AAE) consensus motif; other site
541229009859	AMP binding site [chemical binding]; other site
541229009860	active site
541229009861	CoA binding site [chemical binding]; other site
541229009862	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
541229009863	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229009864	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009865	dimerization interface [polypeptide binding]; other site
541229009866	putative DNA binding site [nucleotide binding]; other site
541229009867	putative Zn2+ binding site [ion binding]; other site
541229009868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229009869	dimerization interface [polypeptide binding]; other site
541229009870	putative DNA binding site [nucleotide binding]; other site
541229009871	putative Zn2+ binding site [ion binding]; other site
541229009872	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
541229009873	active site
541229009874	Glyco_18 domain; Region: Glyco_18; smart00636
541229009875	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
541229009876	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
541229009877	NodB motif; other site
541229009878	putative active site [active]
541229009879	putative catalytic site [active]
541229009880	putative Zn binding site [ion binding]; other site
541229009881	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
541229009882	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
541229009883	DXD motif; other site
541229009884	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
541229009885	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
541229009886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229009887	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229009888	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
541229009889	active site
541229009890	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
541229009891	VPS10 domain; Region: VPS10; smart00602
541229009892	Protein of unknown function (DUF3963); Region: DUF3963; pfam13124
541229009893	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
541229009894	HTH domain; Region: HTH_11; pfam08279
541229009895	WYL domain; Region: WYL; pfam13280
541229009896	ABC-2 type transporter; Region: ABC2_membrane; cl17235
541229009897	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
541229009898	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229009899	Walker A/P-loop; other site
541229009900	ATP binding site [chemical binding]; other site
541229009901	Q-loop/lid; other site
541229009902	ABC transporter signature motif; other site
541229009903	Walker B; other site
541229009904	D-loop; other site
541229009905	H-loop/switch region; other site
541229009906	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
541229009907	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229009908	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229009909	hydroxylamine reductase; Provisional; Region: PRK12310
541229009910	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
541229009911	ACS interaction site; other site
541229009912	CODH interaction site; other site
541229009913	metal cluster binding site [ion binding]; other site
541229009914	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229009915	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
541229009916	active site
541229009917	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
541229009918	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
541229009919	metal binding site [ion binding]; metal-binding site
541229009920	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
541229009921	hypothetical protein; Provisional; Region: PRK06771
541229009922	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229009923	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229009924	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
541229009925	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
541229009926	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
541229009927	dimer interface [polypeptide binding]; other site
541229009928	ligand binding site [chemical binding]; other site
541229009929	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
541229009930	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
541229009931	ligand binding site [chemical binding]; other site
541229009932	flexible hinge region; other site
541229009933	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
541229009934	Protein of unknown function, DUF606; Region: DUF606; pfam04657
541229009935	Protein of unknown function, DUF606; Region: DUF606; pfam04657
541229009936	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229009937	putative transport protein YifK; Provisional; Region: PRK10746
541229009938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229009939	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
541229009940	putative substrate translocation pore; other site
541229009941	Haemolysin XhlA; Region: XhlA; pfam10779
541229009942	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
541229009943	classical (c) SDRs; Region: SDR_c; cd05233
541229009944	NAD(P) binding site [chemical binding]; other site
541229009945	active site
541229009946	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
541229009947	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
541229009948	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
541229009949	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
541229009950	transmembrane helices; other site
541229009951	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229009952	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229009953	Coenzyme A binding pocket [chemical binding]; other site
541229009954	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
541229009955	putative ligand binding residues [chemical binding]; other site
541229009956	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
541229009957	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229009958	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229009959	ABC-ATPase subunit  interface; other site
541229009960	dimer interface [polypeptide binding]; other site
541229009961	putative PBP binding regions; other site
541229009962	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229009963	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229009964	ABC-ATPase subunit  interface; other site
541229009965	dimer interface [polypeptide binding]; other site
541229009966	putative PBP binding regions; other site
541229009967	Protein of unknown function (DUF817); Region: DUF817; pfam05675
541229009968	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
541229009969	DinB superfamily; Region: DinB_2; pfam12867
541229009970	DinB family; Region: DinB; cl17821
541229009971	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
541229009972	Protein of unknown function (DUF2690); Region: DUF2690; pfam10901
541229009973	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229009974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229009975	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229009976	dimerization interface [polypeptide binding]; other site
541229009977	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229009978	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
541229009979	NADP binding site [chemical binding]; other site
541229009980	dimer interface [polypeptide binding]; other site
541229009981	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229009982	catalytic core [active]
541229009983	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229009984	Coenzyme A binding pocket [chemical binding]; other site
541229009985	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
541229009986	MutS domain III; Region: MutS_III; pfam05192
541229009987	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229009988	Walker A/P-loop; other site
541229009989	ATP binding site [chemical binding]; other site
541229009990	Q-loop/lid; other site
541229009991	ABC transporter signature motif; other site
541229009992	Walker B; other site
541229009993	D-loop; other site
541229009994	H-loop/switch region; other site
541229009995	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
541229009996	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
541229009997	active site
541229009998	Na/Ca binding site [ion binding]; other site
541229009999	catalytic site [active]
541229010000	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
541229010001	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
541229010002	oligoendopeptidase F; Region: pepF; TIGR00181
541229010003	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
541229010004	active site
541229010005	Zn binding site [ion binding]; other site
541229010006	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
541229010007	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
541229010008	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
541229010009	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229010010	DNA binding residues [nucleotide binding]
541229010011	drug binding residues [chemical binding]; other site
541229010012	dimer interface [polypeptide binding]; other site
541229010013	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
541229010014	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
541229010015	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
541229010016	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
541229010017	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
541229010018	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
541229010019	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229010020	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229010021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229010022	putative substrate translocation pore; other site
541229010023	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229010024	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229010025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229010026	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
541229010027	putative dimerization interface [polypeptide binding]; other site
541229010028	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
541229010029	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
541229010030	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
541229010031	active site
541229010032	catalytic site [active]
541229010033	metal binding site [ion binding]; metal-binding site
541229010034	FAD binding domain; Region: FAD_binding_3; pfam01494
541229010035	hypothetical protein; Provisional; Region: PRK07236
541229010036	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
541229010037	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229010038	dimerization interface [polypeptide binding]; other site
541229010039	putative DNA binding site [nucleotide binding]; other site
541229010040	putative Zn2+ binding site [ion binding]; other site
541229010041	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
541229010042	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
541229010043	putative NAD(P) binding site [chemical binding]; other site
541229010044	Uncharacterized conserved protein [Function unknown]; Region: COG0397
541229010045	hypothetical protein; Validated; Region: PRK00029
541229010046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
541229010047	TPR motif; other site
541229010048	binding surface
541229010049	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229010050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229010051	TPR motif; other site
541229010052	binding surface
541229010053	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
541229010054	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
541229010055	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
541229010056	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
541229010057	FAD binding domain; Region: FAD_binding_4; pfam01565
541229010058	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
541229010059	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229010060	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229010061	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
541229010062	active site
541229010063	catalytic site [active]
541229010064	putative metal binding site [ion binding]; other site
541229010065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
541229010066	Chitin binding domain; Region: Chitin_bind_3; pfam03067
541229010067	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229010068	Interdomain contacts; other site
541229010069	Cytokine receptor motif; other site
541229010070	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229010071	Interdomain contacts; other site
541229010072	Cytokine receptor motif; other site
541229010073	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
541229010074	Fic/DOC family; Region: Fic; pfam02661
541229010075	Fic family protein [Function unknown]; Region: COG3177
541229010076	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229010077	Spore germination protein; Region: Spore_permease; cl17796
541229010078	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
541229010079	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
541229010080	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
541229010081	PKC phosphorylation site [posttranslational modification]; other site
541229010082	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
541229010083	Peptidase M60-like family; Region: M60-like; pfam13402
541229010084	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
541229010085	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229010086	Interdomain contacts; other site
541229010087	Cytokine receptor motif; other site
541229010088	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
541229010089	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
541229010090	PAS domain S-box; Region: sensory_box; TIGR00229
541229010091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229010092	putative active site [active]
541229010093	heme pocket [chemical binding]; other site
541229010094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229010095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229010096	metal binding site [ion binding]; metal-binding site
541229010097	active site
541229010098	I-site; other site
541229010099	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229010100	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229010101	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229010102	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229010103	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229010104	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229010105	beta-channel forming cytolysin; Region: hlyII; TIGR01002
541229010106	S-layer homology domain; Region: SLH; pfam00395
541229010107	S-layer homology domain; Region: SLH; pfam00395
541229010108	S-layer homology domain; Region: SLH; pfam00395
541229010109	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
541229010110	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
541229010111	active site
541229010112	metal binding site [ion binding]; metal-binding site
541229010113	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
541229010114	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
541229010115	TQXA domain; Region: TQXA_dom; TIGR03934
541229010116	Cna protein B-type domain; Region: Cna_B; pfam05738
541229010117	Cna protein B-type domain; Region: Cna_B; pfam05738
541229010118	Cna protein B-type domain; Region: Cna_B; pfam05738
541229010119	Cna protein B-type domain; Region: Cna_B; pfam05738
541229010120	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
541229010121	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
541229010122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229010123	dimer interface [polypeptide binding]; other site
541229010124	phosphorylation site [posttranslational modification]
541229010125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229010126	ATP binding site [chemical binding]; other site
541229010127	Mg2+ binding site [ion binding]; other site
541229010128	G-X-G motif; other site
541229010129	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
541229010130	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
541229010131	FOG: PKD repeat [General function prediction only]; Region: COG3291
541229010132	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
541229010133	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
541229010134	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
541229010135	MgtC family; Region: MgtC; pfam02308
541229010136	Predicted acetyltransferase [General function prediction only]; Region: COG3981
541229010137	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229010138	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
541229010139	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
541229010140	putative metal binding site [ion binding]; other site
541229010141	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229010142	active site
541229010143	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229010144	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
541229010145	substrate binding pocket [chemical binding]; other site
541229010146	membrane-bound complex binding site; other site
541229010147	hinge residues; other site
541229010148	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
541229010149	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
541229010150	Walker A/P-loop; other site
541229010151	ATP binding site [chemical binding]; other site
541229010152	Q-loop/lid; other site
541229010153	ABC transporter signature motif; other site
541229010154	Walker B; other site
541229010155	D-loop; other site
541229010156	H-loop/switch region; other site
541229010157	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
541229010158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229010159	dimer interface [polypeptide binding]; other site
541229010160	conserved gate region; other site
541229010161	putative PBP binding loops; other site
541229010162	ABC-ATPase subunit interface; other site
541229010163	VanW like protein; Region: VanW; pfam04294
541229010164	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
541229010165	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
541229010166	exonuclease; Provisional; Region: PRK06722
541229010167	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
541229010168	active site
541229010169	catalytic site [active]
541229010170	substrate binding site [chemical binding]; other site
541229010171	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
541229010172	DNA-binding site [nucleotide binding]; DNA binding site
541229010173	RNA-binding motif; other site
541229010174	flavodoxin; Provisional; Region: PRK06703
541229010175	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
541229010176	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
541229010177	nudix motif; other site
541229010178	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
541229010179	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
541229010180	trimer interface [polypeptide binding]; other site
541229010181	active site
541229010182	substrate binding site [chemical binding]; other site
541229010183	CoA binding site [chemical binding]; other site
541229010184	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010185	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010186	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010187	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010188	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010189	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010190	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010191	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010192	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010193	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010194	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010195	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010196	conserved repeat domain; Region: B_ant_repeat; TIGR01451
541229010197	short chain dehydrogenase; Provisional; Region: PRK06924
541229010198	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
541229010199	NADP binding site [chemical binding]; other site
541229010200	homodimer interface [polypeptide binding]; other site
541229010201	active site
541229010202	Predicted acetyltransferase [General function prediction only]; Region: COG3393
541229010203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229010204	argininosuccinate lyase; Provisional; Region: PRK06705
541229010205	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
541229010206	active sites [active]
541229010207	tetramer interface [polypeptide binding]; other site
541229010208	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229010209	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229010210	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
541229010211	active site
541229010212	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
541229010213	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
541229010214	Na binding site [ion binding]; other site
541229010215	Protein of unknown function (DUF997); Region: DUF997; pfam06196
541229010216	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
541229010217	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
541229010218	NAD(P) binding site [chemical binding]; other site
541229010219	catalytic residues [active]
541229010220	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
541229010221	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
541229010222	NAD(P) binding site [chemical binding]; other site
541229010223	homotetramer interface [polypeptide binding]; other site
541229010224	homodimer interface [polypeptide binding]; other site
541229010225	active site
541229010226	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
541229010227	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
541229010228	Divergent PAP2 family; Region: DUF212; pfam02681
541229010229	Predicted permeases [General function prediction only]; Region: RarD; COG2962
541229010230	EamA-like transporter family; Region: EamA; pfam00892
541229010231	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
541229010232	Domain of unknown function DUF59; Region: DUF59; pfam01883
541229010233	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
541229010234	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
541229010235	Walker A motif; other site
541229010236	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
541229010237	MoaE interaction surface [polypeptide binding]; other site
541229010238	MoeB interaction surface [polypeptide binding]; other site
541229010239	thiocarboxylated glycine; other site
541229010240	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
541229010241	MoaE homodimer interface [polypeptide binding]; other site
541229010242	MoaD interaction [polypeptide binding]; other site
541229010243	active site residues [active]
541229010244	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
541229010245	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
541229010246	dimer interface [polypeptide binding]; other site
541229010247	putative functional site; other site
541229010248	putative MPT binding site; other site
541229010249	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
541229010250	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
541229010251	ATP binding site [chemical binding]; other site
541229010252	substrate interface [chemical binding]; other site
541229010253	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
541229010254	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
541229010255	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229010256	FeS/SAM binding site; other site
541229010257	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
541229010258	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
541229010259	Uncharacterized conserved protein [Function unknown]; Region: COG5609
541229010260	Uncharacterized conserved protein [Function unknown]; Region: COG2427
541229010261	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
541229010262	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
541229010263	catalytic loop [active]
541229010264	iron binding site [ion binding]; other site
541229010265	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
541229010266	4Fe-4S binding domain; Region: Fer4; pfam00037
541229010267	4Fe-4S binding domain; Region: Fer4; pfam00037
541229010268	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
541229010269	[4Fe-4S] binding site [ion binding]; other site
541229010270	molybdopterin cofactor binding site; other site
541229010271	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
541229010272	molybdopterin cofactor binding site; other site
541229010273	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229010274	spore germination protein (amino acid permease); Region: 2A0309; TIGR00912
541229010275	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
541229010276	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
541229010277	amino acid transporter; Region: 2A0306; TIGR00909
541229010278	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
541229010279	Tubulin like; Region: Tubulin_2; pfam13809
541229010280	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
541229010281	metal ion-dependent adhesion site (MIDAS); other site
541229010282	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229010283	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
541229010284	active site
541229010285	metal binding site [ion binding]; metal-binding site
541229010286	Methyltransferase domain; Region: Methyltransf_31; pfam13847
541229010287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229010288	S-adenosylmethionine binding site [chemical binding]; other site
541229010289	O-methyltransferase; Region: Methyltransf_2; pfam00891
541229010290	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229010291	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229010292	peptide binding site [polypeptide binding]; other site
541229010293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
541229010294	HTH-like domain; Region: HTH_21; pfam13276
541229010295	Integrase core domain; Region: rve; pfam00665
541229010296	Integrase core domain; Region: rve_2; pfam13333
541229010297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229010298	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229010299	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229010300	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229010301	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229010302	peptide binding site [polypeptide binding]; other site
541229010303	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
541229010304	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
541229010305	peptide binding site [polypeptide binding]; other site
541229010306	Transcriptional regulator [Transcription]; Region: LytR; COG1316
541229010307	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229010308	DNA binding residues [nucleotide binding]
541229010309	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229010310	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
541229010311	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229010312	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229010313	Walker A/P-loop; other site
541229010314	ATP binding site [chemical binding]; other site
541229010315	Q-loop/lid; other site
541229010316	ABC transporter signature motif; other site
541229010317	Walker B; other site
541229010318	D-loop; other site
541229010319	H-loop/switch region; other site
541229010320	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229010321	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229010322	Predicted transcriptional regulator [Transcription]; Region: COG2378
541229010323	HTH domain; Region: HTH_11; pfam08279
541229010324	WYL domain; Region: WYL; pfam13280
541229010325	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
541229010326	dimer interface [polypeptide binding]; other site
541229010327	putative oxidoreductase; Provisional; Region: PRK11579
541229010328	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
541229010329	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
541229010330	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
541229010331	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
541229010332	CAP-like domain; other site
541229010333	active site
541229010334	primary dimer interface [polypeptide binding]; other site
541229010335	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229010336	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229010337	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229010338	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
541229010339	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
541229010340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229010341	ATP binding site [chemical binding]; other site
541229010342	Mg2+ binding site [ion binding]; other site
541229010343	G-X-G motif; other site
541229010344	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
541229010345	anchoring element; other site
541229010346	dimer interface [polypeptide binding]; other site
541229010347	ATP binding site [chemical binding]; other site
541229010348	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
541229010349	active site
541229010350	putative metal-binding site [ion binding]; other site
541229010351	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
541229010352	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
541229010353	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
541229010354	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
541229010355	protein binding site [polypeptide binding]; other site
541229010356	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
541229010357	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229010358	FeS/SAM binding site; other site
541229010359	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
541229010360	Class III ribonucleotide reductase; Region: RNR_III; cd01675
541229010361	effector binding site; other site
541229010362	active site
541229010363	Zn binding site [ion binding]; other site
541229010364	glycine loop; other site
541229010365	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
541229010366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
541229010367	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
541229010368	active site
541229010369	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
541229010370	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229010371	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229010372	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
541229010373	active site
541229010374	acid-soluble spore protein N; Provisional; Region: sspN; PRK09398
541229010375	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
541229010376	DNA polymerase III subunit epsilon; Validated; Region: PRK06807
541229010377	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
541229010378	active site
541229010379	catalytic site [active]
541229010380	substrate binding site [chemical binding]; other site
541229010381	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
541229010382	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
541229010383	catalytic residues [active]
541229010384	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229010385	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229010386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229010387	Walker A/P-loop; other site
541229010388	ATP binding site [chemical binding]; other site
541229010389	Q-loop/lid; other site
541229010390	ABC transporter signature motif; other site
541229010391	Walker B; other site
541229010392	D-loop; other site
541229010393	H-loop/switch region; other site
541229010394	aconitate hydratase; Validated; Region: PRK09277
541229010395	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
541229010396	substrate binding site [chemical binding]; other site
541229010397	ligand binding site [chemical binding]; other site
541229010398	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
541229010399	substrate binding site [chemical binding]; other site
541229010400	acid-soluble spore protein O; Provisional; Region: sspO; PRK02984
541229010401	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229010402	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
541229010403	NodB motif; other site
541229010404	active site
541229010405	catalytic site [active]
541229010406	metal binding site [ion binding]; metal-binding site
541229010407	Small acid-soluble spore protein P family; Region: SspP; cl12105
541229010408	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
541229010409	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
541229010410	putative dimer interface [polypeptide binding]; other site
541229010411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229010412	putative substrate translocation pore; other site
541229010413	putative transporter; Provisional; Region: PRK10054
541229010414	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
541229010415	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
541229010416	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229010417	nudix motif; other site
541229010418	SAP domain; Region: SAP; cl02640
541229010419	acetyl-CoA acetyltransferase; Provisional; Region: PRK06690
541229010420	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
541229010421	dimer interface [polypeptide binding]; other site
541229010422	active site
541229010423	acyl-CoA synthetase; Validated; Region: PRK07638
541229010424	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
541229010425	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
541229010426	acyl-activating enzyme (AAE) consensus motif; other site
541229010427	acyl-activating enzyme (AAE) consensus motif; other site
541229010428	AMP binding site [chemical binding]; other site
541229010429	active site
541229010430	CoA binding site [chemical binding]; other site
541229010431	BioY family; Region: BioY; pfam02632
541229010432	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
541229010433	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
541229010434	dimer interface [polypeptide binding]; other site
541229010435	acyl-activating enzyme (AAE) consensus motif; other site
541229010436	putative active site [active]
541229010437	AMP binding site [chemical binding]; other site
541229010438	putative CoA binding site [chemical binding]; other site
541229010439	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229010440	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229010441	non-specific DNA binding site [nucleotide binding]; other site
541229010442	salt bridge; other site
541229010443	sequence-specific DNA binding site [nucleotide binding]; other site
541229010444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229010445	Coenzyme A binding pocket [chemical binding]; other site
541229010446	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
541229010447	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229010448	amidase catalytic site [active]
541229010449	Zn binding residues [ion binding]; other site
541229010450	substrate binding site [chemical binding]; other site
541229010451	active site
541229010452	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
541229010453	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229010454	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229010455	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229010456	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229010457	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
541229010458	dimer interface [polypeptide binding]; other site
541229010459	putative metal binding site [ion binding]; other site
541229010460	PAS domain S-box; Region: sensory_box; TIGR00229
541229010461	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229010462	putative active site [active]
541229010463	heme pocket [chemical binding]; other site
541229010464	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
541229010465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229010466	putative active site [active]
541229010467	heme pocket [chemical binding]; other site
541229010468	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229010469	dimer interface [polypeptide binding]; other site
541229010470	phosphorylation site [posttranslational modification]
541229010471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229010472	ATP binding site [chemical binding]; other site
541229010473	Mg2+ binding site [ion binding]; other site
541229010474	G-X-G motif; other site
541229010475	Predicted esterase [General function prediction only]; Region: COG0400
541229010476	putative hydrolase; Provisional; Region: PRK11460
541229010477	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
541229010478	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229010479	Zn binding site [ion binding]; other site
541229010480	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
541229010481	Zn binding site [ion binding]; other site
541229010482	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
541229010483	Na binding site [ion binding]; other site
541229010484	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
541229010485	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
541229010486	active site
541229010487	FMN binding site [chemical binding]; other site
541229010488	substrate binding site [chemical binding]; other site
541229010489	3Fe-4S cluster binding site [ion binding]; other site
541229010490	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
541229010491	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
541229010492	FMN binding site [chemical binding]; other site
541229010493	active site
541229010494	substrate binding site [chemical binding]; other site
541229010495	catalytic residue [active]
541229010496	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
541229010497	agmatinase; Region: agmatinase; TIGR01230
541229010498	Agmatinase-like family; Region: Agmatinase-like; cd09990
541229010499	active site
541229010500	oligomer interface [polypeptide binding]; other site
541229010501	Mn binding site [ion binding]; other site
541229010502	imidazolonepropionase; Validated; Region: PRK09356
541229010503	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
541229010504	active site
541229010505	urocanate hydratase; Provisional; Region: PRK05414
541229010506	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
541229010507	active sites [active]
541229010508	tetramer interface [polypeptide binding]; other site
541229010509	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
541229010510	hexamer interface [polypeptide binding]; other site
541229010511	RNA binding site [nucleotide binding]; other site
541229010512	Histidine-zinc binding site [chemical binding]; other site
541229010513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229010514	S-adenosylmethionine binding site [chemical binding]; other site
541229010515	DJ-1 family protein; Region: not_thiJ; TIGR01383
541229010516	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
541229010517	conserved cys residue [active]
541229010518	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
541229010519	AAA domain; Region: AAA_28; pfam13521
541229010520	active site
541229010521	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
541229010522	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
541229010523	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
541229010524	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
541229010525	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
541229010526	EamA-like transporter family; Region: EamA; pfam00892
541229010527	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
541229010528	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
541229010529	metal binding site [ion binding]; metal-binding site
541229010530	dimer interface [polypeptide binding]; other site
541229010531	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
541229010532	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
541229010533	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229010534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229010535	Walker A/P-loop; other site
541229010536	ATP binding site [chemical binding]; other site
541229010537	Q-loop/lid; other site
541229010538	ABC transporter signature motif; other site
541229010539	Walker B; other site
541229010540	D-loop; other site
541229010541	H-loop/switch region; other site
541229010542	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
541229010543	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229010544	The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452
541229010545	putative dimerization interface [polypeptide binding]; other site
541229010546	putative substrate binding pocket [chemical binding]; other site
541229010547	holin-like protein; Validated; Region: PRK01658
541229010548	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
541229010549	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229010550	nudix motif; other site
541229010551	Domain of unknown function (DUF3903); Region: DUF3903; pfam13043
541229010552	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
541229010553	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
541229010554	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
541229010555	active site
541229010556	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229010557	Bacterial SH3 domain; Region: SH3_3; cl17532
541229010558	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229010559	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229010560	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
541229010561	Walker A/P-loop; other site
541229010562	ATP binding site [chemical binding]; other site
541229010563	Q-loop/lid; other site
541229010564	ABC transporter signature motif; other site
541229010565	Walker B; other site
541229010566	D-loop; other site
541229010567	H-loop/switch region; other site
541229010568	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229010569	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
541229010570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229010571	Walker A/P-loop; other site
541229010572	ATP binding site [chemical binding]; other site
541229010573	Q-loop/lid; other site
541229010574	ABC transporter signature motif; other site
541229010575	Walker B; other site
541229010576	D-loop; other site
541229010577	H-loop/switch region; other site
541229010578	hypothetical protein; Provisional; Region: PRK01844
541229010579	Protein of unknown function (DUF2522); Region: DUF2522; pfam10747
541229010580	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
541229010581	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
541229010582	TPP-binding site [chemical binding]; other site
541229010583	dimer interface [polypeptide binding]; other site
541229010584	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
541229010585	PYR/PP interface [polypeptide binding]; other site
541229010586	dimer interface [polypeptide binding]; other site
541229010587	TPP binding site [chemical binding]; other site
541229010588	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
541229010589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229010590	dimer interface [polypeptide binding]; other site
541229010591	conserved gate region; other site
541229010592	ABC-ATPase subunit interface; other site
541229010593	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
541229010594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229010595	dimer interface [polypeptide binding]; other site
541229010596	conserved gate region; other site
541229010597	ABC-ATPase subunit interface; other site
541229010598	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
541229010599	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
541229010600	Walker A/P-loop; other site
541229010601	ATP binding site [chemical binding]; other site
541229010602	Q-loop/lid; other site
541229010603	ABC transporter signature motif; other site
541229010604	Walker B; other site
541229010605	D-loop; other site
541229010606	H-loop/switch region; other site
541229010607	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
541229010608	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229010609	membrane-bound complex binding site; other site
541229010610	hinge residues; other site
541229010611	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
541229010612	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
541229010613	active site
541229010614	metal binding site [ion binding]; metal-binding site
541229010615	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229010616	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
541229010617	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
541229010618	hypothetical protein; Provisional; Region: PRK01546
541229010619	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229010620	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
541229010621	catalytic residues [active]
541229010622	catalytic nucleophile [active]
541229010623	LexA repressor; Validated; Region: PRK00215
541229010624	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229010625	putative DNA binding site [nucleotide binding]; other site
541229010626	putative Zn2+ binding site [ion binding]; other site
541229010627	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
541229010628	Catalytic site [active]
541229010629	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
541229010630	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
541229010631	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
541229010632	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229010633	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229010634	glutamine synthetase, type I; Region: GlnA; TIGR00653
541229010635	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
541229010636	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
541229010637	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
541229010638	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229010639	DNA binding residues [nucleotide binding]
541229010640	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
541229010641	Aluminium resistance protein; Region: Alum_res; pfam06838
541229010642	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
541229010643	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
541229010644	HflX GTPase family; Region: HflX; cd01878
541229010645	G1 box; other site
541229010646	GTP/Mg2+ binding site [chemical binding]; other site
541229010647	Switch I region; other site
541229010648	G2 box; other site
541229010649	G3 box; other site
541229010650	Switch II region; other site
541229010651	G4 box; other site
541229010652	G5 box; other site
541229010653	Predicted membrane protein [Function unknown]; Region: COG2860
541229010654	UPF0126 domain; Region: UPF0126; pfam03458
541229010655	UPF0126 domain; Region: UPF0126; pfam03458
541229010656	stage V sporulation protein K; Region: spore_V_K; TIGR02881
541229010657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229010658	Walker A motif; other site
541229010659	ATP binding site [chemical binding]; other site
541229010660	Walker B motif; other site
541229010661	arginine finger; other site
541229010662	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
541229010663	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229010664	active site
541229010665	catalytic residues [active]
541229010666	DNA binding site [nucleotide binding]
541229010667	Int/Topo IB signature motif; other site
541229010668	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
541229010669	HTH-like domain; Region: HTH_21; pfam13276
541229010670	Integrase core domain; Region: rve; pfam00665
541229010671	Integrase core domain; Region: rve_2; pfam13333
541229010672	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
541229010673	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229010674	Helix-turn-helix domain; Region: HTH_28; pfam13518
541229010675	bacterial Hfq-like; Region: Hfq; cd01716
541229010676	hexamer interface [polypeptide binding]; other site
541229010677	Sm1 motif; other site
541229010678	RNA binding site [nucleotide binding]; other site
541229010679	Sm2 motif; other site
541229010680	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
541229010681	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
541229010682	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229010683	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229010684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
541229010685	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
541229010686	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
541229010687	active site
541229010688	phosphorylation site [posttranslational modification]
541229010689	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
541229010690	active site
541229010691	P-loop; other site
541229010692	phosphorylation site [posttranslational modification]
541229010693	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
541229010694	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
541229010695	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
541229010696	putative substrate binding site [chemical binding]; other site
541229010697	putative ATP binding site [chemical binding]; other site
541229010698	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
541229010699	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
541229010700	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
541229010701	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
541229010702	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
541229010703	dimer interface [polypeptide binding]; other site
541229010704	active site
541229010705	metal binding site [ion binding]; metal-binding site
541229010706	Predicted membrane protein [Function unknown]; Region: COG2322
541229010707	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
541229010708	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
541229010709	Glyco_18 domain; Region: Glyco_18; smart00636
541229010710	putative active site [active]
541229010711	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
541229010712	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229010713	putative active site [active]
541229010714	putative metal binding site [ion binding]; other site
541229010715	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
541229010716	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
541229010717	IHF dimer interface [polypeptide binding]; other site
541229010718	IHF - DNA interface [nucleotide binding]; other site
541229010719	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229010720	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229010721	Coenzyme A binding pocket [chemical binding]; other site
541229010722	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
541229010723	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
541229010724	metal-binding site [ion binding]
541229010725	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
541229010726	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
541229010727	metal-binding site [ion binding]
541229010728	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229010729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229010730	motif II; other site
541229010731	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
541229010732	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
541229010733	metal-binding site [ion binding]
541229010734	Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157
541229010735	putative homodimer interface [polypeptide binding]; other site
541229010736	putative homotetramer interface [polypeptide binding]; other site
541229010737	allosteric switch controlling residues; other site
541229010738	putative metal binding site [ion binding]; other site
541229010739	putative homodimer-homodimer interface [polypeptide binding]; other site
541229010740	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229010741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229010742	DNA binding residues [nucleotide binding]
541229010743	dimerization interface [polypeptide binding]; other site
541229010744	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229010745	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229010746	S-adenosylmethionine binding site [chemical binding]; other site
541229010747	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
541229010748	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
541229010749	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
541229010750	Walker A/P-loop; other site
541229010751	ATP binding site [chemical binding]; other site
541229010752	Q-loop/lid; other site
541229010753	ABC transporter signature motif; other site
541229010754	Walker B; other site
541229010755	D-loop; other site
541229010756	H-loop/switch region; other site
541229010757	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229010758	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229010759	ABC-ATPase subunit  interface; other site
541229010760	dimer interface [polypeptide binding]; other site
541229010761	putative PBP binding regions; other site
541229010762	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229010763	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229010764	ABC-ATPase subunit  interface; other site
541229010765	dimer interface [polypeptide binding]; other site
541229010766	putative PBP binding regions; other site
541229010767	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
541229010768	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
541229010769	putative ligand binding residues [chemical binding]; other site
541229010770	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
541229010771	active site
541229010772	putative catalytic site [active]
541229010773	DNA binding site [nucleotide binding]
541229010774	putative phosphate binding site [ion binding]; other site
541229010775	metal binding site A [ion binding]; metal-binding site
541229010776	AP binding site [nucleotide binding]; other site
541229010777	metal binding site B [ion binding]; metal-binding site
541229010778	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
541229010779	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
541229010780	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229010781	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229010782	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
541229010783	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
541229010784	DNA binding site [nucleotide binding]
541229010785	active site
541229010786	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
541229010787	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
541229010788	endonuclease III; Region: ENDO3c; smart00478
541229010789	minor groove reading motif; other site
541229010790	helix-hairpin-helix signature motif; other site
541229010791	substrate binding pocket [chemical binding]; other site
541229010792	active site
541229010793	peptidase T; Region: peptidase-T; TIGR01882
541229010794	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
541229010795	metal binding site [ion binding]; metal-binding site
541229010796	dimer interface [polypeptide binding]; other site
541229010797	Predicted membrane protein [Function unknown]; Region: COG2364
541229010798	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229010799	hypothetical protein; Provisional; Region: PRK06764
541229010800	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229010801	catalytic core [active]
541229010802	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229010803	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
541229010804	PAS domain S-box; Region: sensory_box; TIGR00229
541229010805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229010806	putative active site [active]
541229010807	heme pocket [chemical binding]; other site
541229010808	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229010809	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229010810	metal binding site [ion binding]; metal-binding site
541229010811	active site
541229010812	I-site; other site
541229010813	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229010814	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
541229010815	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
541229010816	active site
541229010817	homodimer interface [polypeptide binding]; other site
541229010818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229010819	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
541229010820	NAD(P) binding site [chemical binding]; other site
541229010821	active site
541229010822	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
541229010823	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
541229010824	NAD(P) binding site [chemical binding]; other site
541229010825	homodimer interface [polypeptide binding]; other site
541229010826	substrate binding site [chemical binding]; other site
541229010827	active site
541229010828	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
541229010829	Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787
541229010830	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
541229010831	holin-like protein; Validated; Region: PRK01658
541229010832	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
541229010833	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229010834	DNA-binding site [nucleotide binding]; DNA binding site
541229010835	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229010836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229010837	homodimer interface [polypeptide binding]; other site
541229010838	catalytic residue [active]
541229010839	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
541229010840	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229010841	DNA-binding site [nucleotide binding]; DNA binding site
541229010842	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
541229010843	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
541229010844	beta-galactosidase; Region: BGL; TIGR03356
541229010845	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
541229010846	active site
541229010847	catalytic site [active]
541229010848	Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843
541229010849	putative active site [active]
541229010850	putative catalytic triad [active]
541229010851	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
541229010852	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229010853	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
541229010854	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229010855	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
541229010856	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
541229010857	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
541229010858	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
541229010859	Sulfatase; Region: Sulfatase; pfam00884
541229010860	transposase/IS protein; Provisional; Region: PRK09183
541229010861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229010862	Walker A motif; other site
541229010863	ATP binding site [chemical binding]; other site
541229010864	Walker B motif; other site
541229010865	arginine finger; other site
541229010866	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
541229010867	Integrase core domain; Region: rve; pfam00665
541229010868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229010869	binding surface
541229010870	TPR motif; other site
541229010871	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
541229010872	G1 box; other site
541229010873	GTP/Mg2+ binding site [chemical binding]; other site
541229010874	Switch I region; other site
541229010875	G3 box; other site
541229010876	Switch II region; other site
541229010877	G4 box; other site
541229010878	G5 box; other site
541229010879	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
541229010880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229010881	ATP binding site [chemical binding]; other site
541229010882	Mg2+ binding site [ion binding]; other site
541229010883	G-X-G motif; other site
541229010884	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
541229010885	ATP binding site [chemical binding]; other site
541229010886	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
541229010887	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
541229010888	MutS domain I; Region: MutS_I; pfam01624
541229010889	MutS domain II; Region: MutS_II; pfam05188
541229010890	MutS domain III; Region: MutS_III; pfam05192
541229010891	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
541229010892	Walker A/P-loop; other site
541229010893	ATP binding site [chemical binding]; other site
541229010894	Q-loop/lid; other site
541229010895	ABC transporter signature motif; other site
541229010896	Walker B; other site
541229010897	D-loop; other site
541229010898	H-loop/switch region; other site
541229010899	Outer spore coat protein E (CotE); Region: CotE; pfam10628
541229010900	Predicted membrane protein [Function unknown]; Region: COG4550
541229010901	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
541229010902	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
541229010903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229010904	FeS/SAM binding site; other site
541229010905	TRAM domain; Region: TRAM; pfam01938
541229010906	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
541229010907	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
541229010908	TPP-binding site [chemical binding]; other site
541229010909	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
541229010910	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
541229010911	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
541229010912	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
541229010913	dimer interface [polypeptide binding]; other site
541229010914	PYR/PP interface [polypeptide binding]; other site
541229010915	TPP binding site [chemical binding]; other site
541229010916	substrate binding site [chemical binding]; other site
541229010917	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
541229010918	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
541229010919	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
541229010920	active site
541229010921	dimer interface [polypeptide binding]; other site
541229010922	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
541229010923	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
541229010924	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
541229010925	putative active site [active]
541229010926	metal binding site [ion binding]; metal-binding site
541229010927	homodimer binding site [polypeptide binding]; other site
541229010928	phosphodiesterase; Provisional; Region: PRK12704
541229010929	Uncharacterized conserved protein [Function unknown]; Region: COG3334
541229010930	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229010931	Zn2+ binding site [ion binding]; other site
541229010932	Mg2+ binding site [ion binding]; other site
541229010933	recombinase A; Provisional; Region: recA; PRK09354
541229010934	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
541229010935	hexamer interface [polypeptide binding]; other site
541229010936	Walker A motif; other site
541229010937	ATP binding site [chemical binding]; other site
541229010938	Walker B motif; other site
541229010939	competence damage-inducible protein A; Provisional; Region: PRK00549
541229010940	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
541229010941	putative MPT binding site; other site
541229010942	Competence-damaged protein; Region: CinA; pfam02464
541229010943	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
541229010944	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
541229010945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229010946	non-specific DNA binding site [nucleotide binding]; other site
541229010947	salt bridge; other site
541229010948	sequence-specific DNA binding site [nucleotide binding]; other site
541229010949	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
541229010950	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
541229010951	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
541229010952	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
541229010953	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
541229010954	classical (c) SDRs; Region: SDR_c; cd05233
541229010955	NAD(P) binding site [chemical binding]; other site
541229010956	active site
541229010957	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
541229010958	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
541229010959	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
541229010960	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
541229010961	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
541229010962	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
541229010963	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
541229010964	TM-ABC transporter signature motif; other site
541229010965	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
541229010966	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
541229010967	TM-ABC transporter signature motif; other site
541229010968	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
541229010969	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
541229010970	Walker A/P-loop; other site
541229010971	ATP binding site [chemical binding]; other site
541229010972	Q-loop/lid; other site
541229010973	ABC transporter signature motif; other site
541229010974	Walker B; other site
541229010975	D-loop; other site
541229010976	H-loop/switch region; other site
541229010977	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
541229010978	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
541229010979	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
541229010980	ligand binding site [chemical binding]; other site
541229010981	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
541229010982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229010983	DNA-binding site [nucleotide binding]; DNA binding site
541229010984	UTRA domain; Region: UTRA; pfam07702
541229010985	Tetraspanin family; Region: Tetraspannin; pfam00335
541229010986	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
541229010987	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229010988	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
541229010989	YlzJ-like protein; Region: YlzJ; pfam14035
541229010990	Clp protease; Region: CLP_protease; pfam00574
541229010991	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
541229010992	active site
541229010993	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
541229010994	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229010995	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
541229010996	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
541229010997	dihydrodipicolinate synthase; Region: dapA; TIGR00674
541229010998	dimer interface [polypeptide binding]; other site
541229010999	active site
541229011000	catalytic residue [active]
541229011001	aspartate kinase I; Reviewed; Region: PRK08210
541229011002	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
541229011003	nucleotide binding site [chemical binding]; other site
541229011004	substrate binding site [chemical binding]; other site
541229011005	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
541229011006	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
541229011007	Flavoprotein; Region: Flavoprotein; cl08021
541229011008	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229011009	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
541229011010	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
541229011011	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
541229011012	active site
541229011013	N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123
541229011014	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
541229011015	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229011016	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229011017	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229011018	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
541229011019	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229011020	Phage tail protein; Region: Sipho_tail; pfam05709
541229011021	Phage tail protein; Region: Sipho_tail; cl17486
541229011022	Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730
541229011023	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
541229011024	Phage-related protein [Function unknown]; Region: COG5412
541229011025	membrane protein P6; Region: PHA01399
541229011026	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
541229011027	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
541229011028	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
541229011029	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
541229011030	oligomer interface [polypeptide binding]; other site
541229011031	active site residues [active]
541229011032	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
541229011033	Phage-related protein [Function unknown]; Region: COG4695; cl01923
541229011034	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
541229011035	Phage terminase, small subunit; Region: Terminase_4; cl01525
541229011036	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
541229011037	HNH endonuclease; Region: HNH; pfam01844
541229011038	active site
541229011039	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
541229011040	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
541229011041	active site
541229011042	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
541229011043	Int/Topo IB signature motif; other site
541229011044	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
541229011045	Protein of unknown function (DUF3983); Region: DUF3983; pfam13137
541229011046	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
541229011047	Protein of unknown function (DUF3954); Region: DUF3954; pfam13128
541229011048	replicative DNA helicase; Provisional; Region: PRK06749
541229011049	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
541229011050	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
541229011051	Walker A motif; other site
541229011052	ATP binding site [chemical binding]; other site
541229011053	Walker B motif; other site
541229011054	DNA binding loops [nucleotide binding]
541229011055	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229011056	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229011057	sequence-specific DNA binding site [nucleotide binding]; other site
541229011058	salt bridge; other site
541229011059	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229011060	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229011061	non-specific DNA binding site [nucleotide binding]; other site
541229011062	salt bridge; other site
541229011063	sequence-specific DNA binding site [nucleotide binding]; other site
541229011064	Domain of unknown function (DUF955); Region: DUF955; cl01076
541229011065	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229011066	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
541229011067	catalytic residues [active]
541229011068	catalytic nucleophile [active]
541229011069	Recombinase; Region: Recombinase; pfam07508
541229011070	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
541229011071	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
541229011072	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
541229011073	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
541229011074	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
541229011075	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
541229011076	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
541229011077	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
541229011078	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
541229011079	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
541229011080	NodB motif; other site
541229011081	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
541229011082	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
541229011083	RNase E interface [polypeptide binding]; other site
541229011084	trimer interface [polypeptide binding]; other site
541229011085	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
541229011086	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
541229011087	RNase E interface [polypeptide binding]; other site
541229011088	trimer interface [polypeptide binding]; other site
541229011089	active site
541229011090	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
541229011091	putative nucleic acid binding region [nucleotide binding]; other site
541229011092	G-X-X-G motif; other site
541229011093	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
541229011094	RNA binding site [nucleotide binding]; other site
541229011095	domain interface; other site
541229011096	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
541229011097	16S/18S rRNA binding site [nucleotide binding]; other site
541229011098	S13e-L30e interaction site [polypeptide binding]; other site
541229011099	25S rRNA binding site [nucleotide binding]; other site
541229011100	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
541229011101	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
541229011102	active site
541229011103	Riboflavin kinase; Region: Flavokinase; pfam01687
541229011104	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
541229011105	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
541229011106	RNA binding site [nucleotide binding]; other site
541229011107	active site
541229011108	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
541229011109	Protein of unknown function (DUF503); Region: DUF503; pfam04456
541229011110	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
541229011111	translation initiation factor IF-2; Region: IF-2; TIGR00487
541229011112	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
541229011113	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
541229011114	G1 box; other site
541229011115	putative GEF interaction site [polypeptide binding]; other site
541229011116	GTP/Mg2+ binding site [chemical binding]; other site
541229011117	Switch I region; other site
541229011118	G2 box; other site
541229011119	G3 box; other site
541229011120	Switch II region; other site
541229011121	G4 box; other site
541229011122	G5 box; other site
541229011123	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
541229011124	Translation-initiation factor 2; Region: IF-2; pfam11987
541229011125	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
541229011126	hypothetical protein; Provisional; Region: PRK07714
541229011127	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
541229011128	putative RNA binding cleft [nucleotide binding]; other site
541229011129	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
541229011130	NusA N-terminal domain; Region: NusA_N; pfam08529
541229011131	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
541229011132	RNA binding site [nucleotide binding]; other site
541229011133	homodimer interface [polypeptide binding]; other site
541229011134	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
541229011135	G-X-X-G motif; other site
541229011136	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
541229011137	G-X-X-G motif; other site
541229011138	ribosome maturation protein RimP; Reviewed; Region: PRK00092
541229011139	Sm and related proteins; Region: Sm_like; cl00259
541229011140	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
541229011141	putative oligomer interface [polypeptide binding]; other site
541229011142	putative RNA binding site [nucleotide binding]; other site
541229011143	DNA polymerase III PolC; Validated; Region: polC; PRK00448
541229011144	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
541229011145	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
541229011146	generic binding surface II; other site
541229011147	generic binding surface I; other site
541229011148	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
541229011149	active site
541229011150	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
541229011151	active site
541229011152	catalytic site [active]
541229011153	substrate binding site [chemical binding]; other site
541229011154	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
541229011155	prolyl-tRNA synthetase; Provisional; Region: PRK09194
541229011156	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
541229011157	dimer interface [polypeptide binding]; other site
541229011158	motif 1; other site
541229011159	active site
541229011160	motif 2; other site
541229011161	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
541229011162	putative deacylase active site [active]
541229011163	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
541229011164	active site
541229011165	motif 3; other site
541229011166	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
541229011167	anticodon binding site; other site
541229011168	RIP metalloprotease RseP; Region: TIGR00054
541229011169	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
541229011170	active site
541229011171	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
541229011172	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
541229011173	protein binding site [polypeptide binding]; other site
541229011174	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
541229011175	putative substrate binding region [chemical binding]; other site
541229011176	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
541229011177	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
541229011178	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
541229011179	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
541229011180	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
541229011181	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
541229011182	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
541229011183	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
541229011184	catalytic residue [active]
541229011185	putative FPP diphosphate  binding site; other site
541229011186	putative FPP binding hydrophobic cleft; other site
541229011187	dimer interface [polypeptide binding]; other site
541229011188	putative IPP diphosphate binding site; other site
541229011189	ribosome recycling factor; Reviewed; Region: frr; PRK00083
541229011190	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
541229011191	hinge region; other site
541229011192	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
541229011193	putative nucleotide binding site [chemical binding]; other site
541229011194	uridine monophosphate binding site [chemical binding]; other site
541229011195	homohexameric interface [polypeptide binding]; other site
541229011196	elongation factor Ts; Provisional; Region: tsf; PRK09377
541229011197	UBA/TS-N domain; Region: UBA; pfam00627
541229011198	Elongation factor TS; Region: EF_TS; pfam00889
541229011199	Elongation factor TS; Region: EF_TS; pfam00889
541229011200	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
541229011201	rRNA interaction site [nucleotide binding]; other site
541229011202	S8 interaction site; other site
541229011203	putative laminin-1 binding site; other site
541229011204	transcriptional repressor CodY; Validated; Region: PRK04158
541229011205	CodY GAF-like domain; Region: CodY; pfam06018
541229011206	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
541229011207	potential frameshift: common BLAST hit: gi|296504324|ref|YP_003666024.1| ATP-dependent protease ATP-binding subunit
541229011208	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
541229011209	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
541229011210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229011211	Walker A motif; other site
541229011212	ATP binding site [chemical binding]; other site
541229011213	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
541229011214	active site
541229011215	HslU subunit interaction site [polypeptide binding]; other site
541229011216	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
541229011217	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
541229011218	active site
541229011219	Int/Topo IB signature motif; other site
541229011220	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
541229011221	Glucose inhibited division protein A; Region: GIDA; pfam01134
541229011222	DNA topoisomerase I; Validated; Region: PRK05582
541229011223	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
541229011224	active site
541229011225	interdomain interaction site; other site
541229011226	putative metal-binding site [ion binding]; other site
541229011227	nucleotide binding site [chemical binding]; other site
541229011228	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
541229011229	domain I; other site
541229011230	DNA binding groove [nucleotide binding]
541229011231	phosphate binding site [ion binding]; other site
541229011232	domain II; other site
541229011233	domain III; other site
541229011234	nucleotide binding site [chemical binding]; other site
541229011235	catalytic site [active]
541229011236	domain IV; other site
541229011237	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
541229011238	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
541229011239	DNA protecting protein DprA; Region: dprA; TIGR00732
541229011240	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
541229011241	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
541229011242	CoA binding domain; Region: CoA_binding; smart00881
541229011243	CoA-ligase; Region: Ligase_CoA; pfam00549
541229011244	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
541229011245	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
541229011246	CoA-ligase; Region: Ligase_CoA; pfam00549
541229011247	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
541229011248	RNA/DNA hybrid binding site [nucleotide binding]; other site
541229011249	active site
541229011250	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
541229011251	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
541229011252	GTP/Mg2+ binding site [chemical binding]; other site
541229011253	G4 box; other site
541229011254	G5 box; other site
541229011255	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
541229011256	G1 box; other site
541229011257	G1 box; other site
541229011258	GTP/Mg2+ binding site [chemical binding]; other site
541229011259	Switch I region; other site
541229011260	G2 box; other site
541229011261	G2 box; other site
541229011262	G3 box; other site
541229011263	G3 box; other site
541229011264	Switch II region; other site
541229011265	Switch II region; other site
541229011266	G4 box; other site
541229011267	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
541229011268	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
541229011269	Catalytic site [active]
541229011270	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
541229011271	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
541229011272	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
541229011273	RimM N-terminal domain; Region: RimM; pfam01782
541229011274	PRC-barrel domain; Region: PRC; pfam05239
541229011275	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
541229011276	KH domain; Region: KH_4; pfam13083
541229011277	G-X-X-G motif; other site
541229011278	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
541229011279	signal recognition particle protein; Provisional; Region: PRK10867
541229011280	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
541229011281	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
541229011282	P loop; other site
541229011283	GTP binding site [chemical binding]; other site
541229011284	Signal peptide binding domain; Region: SRP_SPB; pfam02978
541229011285	putative DNA-binding protein; Validated; Region: PRK00118
541229011286	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
541229011287	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
541229011288	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
541229011289	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
541229011290	P loop; other site
541229011291	GTP binding site [chemical binding]; other site
541229011292	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
541229011293	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
541229011294	Walker A/P-loop; other site
541229011295	ATP binding site [chemical binding]; other site
541229011296	Q-loop/lid; other site
541229011297	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
541229011298	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
541229011299	ABC transporter signature motif; other site
541229011300	Walker B; other site
541229011301	D-loop; other site
541229011302	H-loop/switch region; other site
541229011303	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
541229011304	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
541229011305	dimerization interface [polypeptide binding]; other site
541229011306	active site
541229011307	metal binding site [ion binding]; metal-binding site
541229011308	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
541229011309	dsRNA binding site [nucleotide binding]; other site
541229011310	acyl carrier protein; Provisional; Region: acpP; PRK00982
541229011311	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
541229011312	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
541229011313	NAD(P) binding site [chemical binding]; other site
541229011314	homotetramer interface [polypeptide binding]; other site
541229011315	homodimer interface [polypeptide binding]; other site
541229011316	active site
541229011317	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
541229011318	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
541229011319	putative phosphate acyltransferase; Provisional; Region: PRK05331
541229011320	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
541229011321	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
541229011322	active site 2 [active]
541229011323	active site 1 [active]
541229011324	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
541229011325	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
541229011326	generic binding surface II; other site
541229011327	ssDNA binding site; other site
541229011328	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229011329	ATP binding site [chemical binding]; other site
541229011330	putative Mg++ binding site [ion binding]; other site
541229011331	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229011332	nucleotide binding region [chemical binding]; other site
541229011333	ATP-binding site [chemical binding]; other site
541229011334	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
541229011335	DAK2 domain; Region: Dak2; pfam02734
541229011336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
541229011337	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
541229011338	Thiamine pyrophosphokinase; Region: TPK; cd07995
541229011339	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
541229011340	active site
541229011341	dimerization interface [polypeptide binding]; other site
541229011342	thiamine binding site [chemical binding]; other site
541229011343	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
541229011344	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
541229011345	substrate binding site [chemical binding]; other site
541229011346	hexamer interface [polypeptide binding]; other site
541229011347	metal binding site [ion binding]; metal-binding site
541229011348	GTPase RsgA; Reviewed; Region: PRK00098
541229011349	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
541229011350	RNA binding site [nucleotide binding]; other site
541229011351	homodimer interface [polypeptide binding]; other site
541229011352	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
541229011353	GTPase/Zn-binding domain interface [polypeptide binding]; other site
541229011354	GTP/Mg2+ binding site [chemical binding]; other site
541229011355	G4 box; other site
541229011356	G5 box; other site
541229011357	G1 box; other site
541229011358	Switch I region; other site
541229011359	G2 box; other site
541229011360	G3 box; other site
541229011361	Switch II region; other site
541229011362	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
541229011363	Catalytic domain of Protein Kinases; Region: PKc; cd00180
541229011364	active site
541229011365	ATP binding site [chemical binding]; other site
541229011366	substrate binding site [chemical binding]; other site
541229011367	activation loop (A-loop); other site
541229011368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
541229011369	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
541229011370	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
541229011371	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
541229011372	Protein phosphatase 2C; Region: PP2C; pfam00481
541229011373	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
541229011374	active site
541229011375	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
541229011376	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229011377	FeS/SAM binding site; other site
541229011378	16S rRNA methyltransferase B; Provisional; Region: PRK14902
541229011379	NusB family; Region: NusB; pfam01029
541229011380	putative RNA binding site [nucleotide binding]; other site
541229011381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229011382	S-adenosylmethionine binding site [chemical binding]; other site
541229011383	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
541229011384	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
541229011385	putative active site [active]
541229011386	substrate binding site [chemical binding]; other site
541229011387	putative cosubstrate binding site; other site
541229011388	catalytic site [active]
541229011389	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
541229011390	substrate binding site [chemical binding]; other site
541229011391	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
541229011392	active site
541229011393	catalytic residues [active]
541229011394	metal binding site [ion binding]; metal-binding site
541229011395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229011396	primosomal protein N' Region: priA; TIGR00595
541229011397	ATP binding site [chemical binding]; other site
541229011398	putative Mg++ binding site [ion binding]; other site
541229011399	helicase superfamily c-terminal domain; Region: HELICc; smart00490
541229011400	nucleotide binding region [chemical binding]; other site
541229011401	ATP-binding site [chemical binding]; other site
541229011402	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
541229011403	Flavoprotein; Region: Flavoprotein; pfam02441
541229011404	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
541229011405	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
541229011406	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
541229011407	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
541229011408	catalytic site [active]
541229011409	G-X2-G-X-G-K; other site
541229011410	hypothetical protein; Provisional; Region: PRK04323
541229011411	hypothetical protein; Provisional; Region: PRK11820
541229011412	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
541229011413	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
541229011414	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
541229011415	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
541229011416	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229011417	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
541229011418	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229011419	motif II; other site
541229011420	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
541229011421	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
541229011422	Domain of unknown function (DUF814); Region: DUF814; pfam05670
541229011423	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
541229011424	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
541229011425	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
541229011426	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
541229011427	active site
541229011428	DinB superfamily; Region: DinB_2; pfam12867
541229011429	YoqO-like protein; Region: YoqO; pfam14037
541229011430	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
541229011431	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
541229011432	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
541229011433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229011434	motif II; other site
541229011435	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229011436	active site
541229011437	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
541229011438	active site
541229011439	dimer interface [polypeptide binding]; other site
541229011440	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
541229011441	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
541229011442	heterodimer interface [polypeptide binding]; other site
541229011443	active site
541229011444	FMN binding site [chemical binding]; other site
541229011445	homodimer interface [polypeptide binding]; other site
541229011446	substrate binding site [chemical binding]; other site
541229011447	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
541229011448	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
541229011449	FAD binding pocket [chemical binding]; other site
541229011450	FAD binding motif [chemical binding]; other site
541229011451	phosphate binding motif [ion binding]; other site
541229011452	beta-alpha-beta structure motif; other site
541229011453	NAD binding pocket [chemical binding]; other site
541229011454	Iron coordination center [ion binding]; other site
541229011455	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
541229011456	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
541229011457	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
541229011458	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
541229011459	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
541229011460	ATP-grasp domain; Region: ATP-grasp_4; cl17255
541229011461	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
541229011462	IMP binding site; other site
541229011463	dimer interface [polypeptide binding]; other site
541229011464	interdomain contacts; other site
541229011465	partial ornithine binding site; other site
541229011466	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
541229011467	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
541229011468	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
541229011469	catalytic site [active]
541229011470	subunit interface [polypeptide binding]; other site
541229011471	dihydroorotase; Validated; Region: pyrC; PRK09357
541229011472	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
541229011473	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
541229011474	active site
541229011475	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
541229011476	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
541229011477	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
541229011478	uracil transporter; Provisional; Region: PRK10720
541229011479	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
541229011480	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229011481	active site
541229011482	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
541229011483	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229011484	RNA binding surface [nucleotide binding]; other site
541229011485	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
541229011486	active site
541229011487	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
541229011488	lipoprotein signal peptidase; Provisional; Region: PRK14787
541229011489	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
541229011490	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
541229011491	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
541229011492	active site
541229011493	HIGH motif; other site
541229011494	nucleotide binding site [chemical binding]; other site
541229011495	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
541229011496	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
541229011497	active site
541229011498	KMSKS motif; other site
541229011499	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
541229011500	tRNA binding surface [nucleotide binding]; other site
541229011501	anticodon binding site; other site
541229011502	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
541229011503	DivIVA protein; Region: DivIVA; pfam05103
541229011504	DivIVA domain; Region: DivI1A_domain; TIGR03544
541229011505	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
541229011506	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
541229011507	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229011508	RNA binding surface [nucleotide binding]; other site
541229011509	YGGT family; Region: YGGT; pfam02325
541229011510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
541229011511	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
541229011512	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
541229011513	catalytic residue [active]
541229011514	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
541229011515	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
541229011516	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
541229011517	sporulation sigma factor SigG; Reviewed; Region: PRK08215
541229011518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229011519	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229011520	DNA binding residues [nucleotide binding]
541229011521	sporulation sigma factor SigE; Reviewed; Region: PRK08301
541229011522	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229011523	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229011524	DNA binding residues [nucleotide binding]
541229011525	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
541229011526	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
541229011527	cell division protein FtsZ; Validated; Region: PRK09330
541229011528	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
541229011529	nucleotide binding site [chemical binding]; other site
541229011530	SulA interaction site; other site
541229011531	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
541229011532	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
541229011533	nucleotide binding site [chemical binding]; other site
541229011534	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
541229011535	Cell division protein FtsA; Region: FtsA; pfam14450
541229011536	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
541229011537	Cell division protein FtsQ; Region: FtsQ; pfam03799
541229011538	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
541229011539	FAD binding domain; Region: FAD_binding_4; pfam01565
541229011540	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
541229011541	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
541229011542	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
541229011543	active site
541229011544	homodimer interface [polypeptide binding]; other site
541229011545	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
541229011546	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
541229011547	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
541229011548	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
541229011549	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
541229011550	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
541229011551	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
541229011552	Mg++ binding site [ion binding]; other site
541229011553	putative catalytic motif [active]
541229011554	putative substrate binding site [chemical binding]; other site
541229011555	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
541229011556	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
541229011557	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
541229011558	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
541229011559	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
541229011560	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229011561	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229011562	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
541229011563	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229011564	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229011565	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229011566	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
541229011567	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
541229011568	Cell division protein FtsL; Region: FtsL; cl11433
541229011569	MraW methylase family; Region: Methyltransf_5; pfam01795
541229011570	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
541229011571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
541229011572	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
541229011573	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
541229011574	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
541229011575	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
541229011576	hypothetical protein; Provisional; Region: PRK13688
541229011577	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229011578	Coenzyme A binding pocket [chemical binding]; other site
541229011579	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
541229011580	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
541229011581	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
541229011582	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
541229011583	hypothetical protein; Provisional; Region: PRK13670
541229011584	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
541229011585	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
541229011586	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
541229011587	protein binding site [polypeptide binding]; other site
541229011588	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
541229011589	hypothetical protein; Provisional; Region: PRK10279
541229011590	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
541229011591	active site
541229011592	nucleophile elbow; other site
541229011593	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
541229011594	Nucleoside recognition; Region: Gate; pfam07670
541229011595	Nucleoside recognition; Region: Gate; pfam07670
541229011596	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
541229011597	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
541229011598	active site
541229011599	(T/H)XGH motif; other site
541229011600	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
541229011601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229011602	S-adenosylmethionine binding site [chemical binding]; other site
541229011603	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
541229011604	Protein of unknown function (DUF964); Region: DUF964; pfam06133
541229011605	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229011606	catalytic core [active]
541229011607	YlbE-like protein; Region: YlbE; pfam14003
541229011608	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
541229011609	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
541229011610	YugN-like family; Region: YugN; pfam08868
541229011611	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
541229011612	HTH-like domain; Region: HTH_21; pfam13276
541229011613	Integrase core domain; Region: rve; pfam00665
541229011614	Integrase core domain; Region: rve_2; pfam13333
541229011615	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
541229011616	active site
541229011617	catalytic triad [active]
541229011618	dimer interface [polypeptide binding]; other site
541229011619	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
541229011620	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
541229011621	putative active site [active]
541229011622	putative NTP binding site [chemical binding]; other site
541229011623	putative nucleic acid binding site [nucleotide binding]; other site
541229011624	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
541229011625	active site
541229011626	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
541229011627	cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737
541229011628	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
541229011629	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
541229011630	Subunit I/III interface [polypeptide binding]; other site
541229011631	Subunit III/IV interface [polypeptide binding]; other site
541229011632	cytochrome aa3 quinol oxidase, subunit I; Region: QoxB; TIGR02882
541229011633	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
541229011634	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
541229011635	D-pathway; other site
541229011636	Low-spin heme binding site [chemical binding]; other site
541229011637	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
541229011638	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
541229011639	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
541229011640	Cytochrome c; Region: Cytochrom_C; pfam00034
541229011641	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
541229011642	UbiA prenyltransferase family; Region: UbiA; pfam01040
541229011643	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
541229011644	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
541229011645	pyruvate carboxylase; Reviewed; Region: PRK12999
541229011646	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
541229011647	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
541229011648	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
541229011649	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
541229011650	active site
541229011651	catalytic residues [active]
541229011652	metal binding site [ion binding]; metal-binding site
541229011653	homodimer binding site [polypeptide binding]; other site
541229011654	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
541229011655	carboxyltransferase (CT) interaction site; other site
541229011656	biotinylation site [posttranslational modification]; other site
541229011657	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
541229011658	hypothetical protein; Provisional; Region: PRK13666
541229011659	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
541229011660	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
541229011661	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
541229011662	putative active site [active]
541229011663	PhoH-like protein; Region: PhoH; pfam02562
541229011664	hypothetical protein; Provisional; Region: PRK06733
541229011665	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
541229011666	YlaH-like protein; Region: YlaH; pfam14036
541229011667	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
541229011668	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
541229011669	G1 box; other site
541229011670	putative GEF interaction site [polypeptide binding]; other site
541229011671	GTP/Mg2+ binding site [chemical binding]; other site
541229011672	Switch I region; other site
541229011673	G2 box; other site
541229011674	G3 box; other site
541229011675	Switch II region; other site
541229011676	G4 box; other site
541229011677	G5 box; other site
541229011678	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
541229011679	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
541229011680	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
541229011681	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
541229011682	active site
541229011683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
541229011684	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
541229011685	hypothetical protein; Provisional; Region: PRK04387
541229011686	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
541229011687	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
541229011688	homodimer interface [polypeptide binding]; other site
541229011689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229011690	catalytic residue [active]
541229011691	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
541229011692	transglutaminase; Provisional; Region: tgl; PRK03187
541229011693	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
541229011694	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
541229011695	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
541229011696	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
541229011697	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
541229011698	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
541229011699	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229011700	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
541229011701	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
541229011702	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
541229011703	E3 interaction surface; other site
541229011704	lipoyl attachment site [posttranslational modification]; other site
541229011705	e3 binding domain; Region: E3_binding; pfam02817
541229011706	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
541229011707	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
541229011708	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
541229011709	alpha subunit interface [polypeptide binding]; other site
541229011710	TPP binding site [chemical binding]; other site
541229011711	heterodimer interface [polypeptide binding]; other site
541229011712	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
541229011713	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
541229011714	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
541229011715	TPP-binding site [chemical binding]; other site
541229011716	heterodimer interface [polypeptide binding]; other site
541229011717	tetramer interface [polypeptide binding]; other site
541229011718	phosphorylation loop region [posttranslational modification]
541229011719	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
541229011720	active site
541229011721	catalytic residues [active]
541229011722	metal binding site [ion binding]; metal-binding site
541229011723	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229011724	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229011725	active site
541229011726	motif I; other site
541229011727	motif II; other site
541229011728	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229011729	hypothetical protein; Provisional; Region: PRK13667
541229011730	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
541229011731	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229011732	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
541229011733	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
541229011734	TrkA-N domain; Region: TrkA_N; pfam02254
541229011735	TrkA-C domain; Region: TrkA_C; pfam02080
541229011736	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
541229011737	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
541229011738	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
541229011739	metal binding site [ion binding]; metal-binding site
541229011740	putative dimer interface [polypeptide binding]; other site
541229011741	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
541229011742	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
541229011743	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
541229011744	trimer interface [polypeptide binding]; other site
541229011745	active site
541229011746	substrate binding site [chemical binding]; other site
541229011747	CoA binding site [chemical binding]; other site
541229011748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229011749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229011750	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229011751	dimerization interface [polypeptide binding]; other site
541229011752	FOG: CBS domain [General function prediction only]; Region: COG0517
541229011753	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
541229011754	Antirepressor AbbA; Region: AbbA_antirepres; pfam14156
541229011755	Protein of unknown function (DUF458); Region: DUF458; cl00861
541229011756	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
541229011757	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
541229011758	catalytic residues [active]
541229011759	Protein of unknown function (DUF3993); Region: DUF3993; pfam13158
541229011760	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229011761	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
541229011762	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
541229011763	short chain dehydrogenase; Provisional; Region: PRK07677
541229011764	NAD(P) binding site [chemical binding]; other site
541229011765	substrate binding site [chemical binding]; other site
541229011766	homotetramer interface [polypeptide binding]; other site
541229011767	active site
541229011768	homodimer interface [polypeptide binding]; other site
541229011769	phosphodiesterase YaeI; Provisional; Region: PRK11340
541229011770	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
541229011771	putative active site [active]
541229011772	putative metal binding site [ion binding]; other site
541229011773	polyphosphate kinase; Provisional; Region: PRK05443
541229011774	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
541229011775	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
541229011776	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
541229011777	putative domain interface [polypeptide binding]; other site
541229011778	putative active site [active]
541229011779	catalytic site [active]
541229011780	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
541229011781	putative domain interface [polypeptide binding]; other site
541229011782	putative active site [active]
541229011783	catalytic site [active]
541229011784	exopolyphosphatase; Region: exo_poly_only; TIGR03706
541229011785	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
541229011786	YkyB-like protein; Region: YkyB; pfam14177
541229011787	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
541229011788	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229011789	I-site; other site
541229011790	active site
541229011791	metal binding site [ion binding]; metal-binding site
541229011792	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229011793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229011794	putative substrate translocation pore; other site
541229011795	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229011796	Transcriptional regulator PadR-like family; Region: PadR; cl17335
541229011797	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
541229011798	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
541229011799	THF binding site; other site
541229011800	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
541229011801	substrate binding site [chemical binding]; other site
541229011802	THF binding site; other site
541229011803	zinc-binding site [ion binding]; other site
541229011804	Competence protein J (ComJ); Region: ComJ; pfam11033
541229011805	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
541229011806	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
541229011807	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
541229011808	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229011809	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229011810	dimer interface [polypeptide binding]; other site
541229011811	phosphorylation site [posttranslational modification]
541229011812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229011813	ATP binding site [chemical binding]; other site
541229011814	Mg2+ binding site [ion binding]; other site
541229011815	G-X-G motif; other site
541229011816	aminotransferase A; Validated; Region: PRK07683
541229011817	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229011818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229011819	homodimer interface [polypeptide binding]; other site
541229011820	catalytic residue [active]
541229011821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229011822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229011823	DNA binding site [nucleotide binding]
541229011824	domain linker motif; other site
541229011825	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
541229011826	putative dimerization interface [polypeptide binding]; other site
541229011827	putative ligand binding site [chemical binding]; other site
541229011828	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
541229011829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229011830	dimer interface [polypeptide binding]; other site
541229011831	conserved gate region; other site
541229011832	putative PBP binding loops; other site
541229011833	ABC-ATPase subunit interface; other site
541229011834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229011835	dimer interface [polypeptide binding]; other site
541229011836	conserved gate region; other site
541229011837	putative PBP binding loops; other site
541229011838	ABC-ATPase subunit interface; other site
541229011839	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
541229011840	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
541229011841	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
541229011842	homodimer interface [polypeptide binding]; other site
541229011843	maltodextrin glucosidase; Provisional; Region: PRK10785
541229011844	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
541229011845	active site
541229011846	homodimer interface [polypeptide binding]; other site
541229011847	catalytic site [active]
541229011848	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
541229011849	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
541229011850	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
541229011851	Ca binding site [ion binding]; other site
541229011852	active site
541229011853	catalytic site [active]
541229011854	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
541229011855	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
541229011856	Walker A/P-loop; other site
541229011857	ATP binding site [chemical binding]; other site
541229011858	Q-loop/lid; other site
541229011859	ABC transporter signature motif; other site
541229011860	Walker B; other site
541229011861	D-loop; other site
541229011862	H-loop/switch region; other site
541229011863	TOBE domain; Region: TOBE_2; pfam08402
541229011864	hypothetical protein; Provisional; Region: PRK06720
541229011865	NAD(P) binding site [chemical binding]; other site
541229011866	Protein of unknown function (DUF3997); Region: DUF3997; pfam13162
541229011867	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
541229011868	Predicted ATPase [General function prediction only]; Region: COG3910
541229011869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229011870	Walker A/P-loop; other site
541229011871	ATP binding site [chemical binding]; other site
541229011872	Q-loop/lid; other site
541229011873	ABC transporter signature motif; other site
541229011874	Walker B; other site
541229011875	D-loop; other site
541229011876	H-loop/switch region; other site
541229011877	putative acyltransferase; Provisional; Region: PRK05790
541229011878	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
541229011879	dimer interface [polypeptide binding]; other site
541229011880	active site
541229011881	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
541229011882	nudix motif; other site
541229011883	Protein of unknown function (DUF3928); Region: DUF3928; pfam13065
541229011884	hypothetical protein; Validated; Region: PRK07668
541229011885	hypothetical protein; Validated; Region: PRK07668
541229011886	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229011887	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229011888	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
541229011889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229011890	NAD(P) binding site [chemical binding]; other site
541229011891	active site
541229011892	YvrJ protein family; Region: YvrJ; pfam12841
541229011893	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
541229011894	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
541229011895	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
541229011896	Phosphotransferase enzyme family; Region: APH; pfam01636
541229011897	Predicted amidohydrolase [General function prediction only]; Region: COG0388
541229011898	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
541229011899	putative active site [active]
541229011900	catalytic triad [active]
541229011901	putative dimer interface [polypeptide binding]; other site
541229011902	transaminase; Reviewed; Region: PRK08068
541229011903	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229011904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229011905	homodimer interface [polypeptide binding]; other site
541229011906	catalytic residue [active]
541229011907	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
541229011908	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
541229011909	dimer interface [polypeptide binding]; other site
541229011910	active site
541229011911	catalytic residue [active]
541229011912	metal binding site [ion binding]; metal-binding site
541229011913	2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552
541229011914	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
541229011915	methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754
541229011916	intersubunit interface [polypeptide binding]; other site
541229011917	active site
541229011918	Zn2+ binding site [ion binding]; other site
541229011919	ARD/ARD' family; Region: ARD; pfam03079
541229011920	Cupin domain; Region: Cupin_2; pfam07883
541229011921	Protein of unknown function (DUF3909); Region: DUF3909; pfam13077
541229011922	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
541229011923	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
541229011924	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
541229011925	Beta-lactamase; Region: Beta-lactamase; pfam00144
541229011926	PAS domain; Region: PAS_8; pfam13188
541229011927	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229011928	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229011929	metal binding site [ion binding]; metal-binding site
541229011930	active site
541229011931	I-site; other site
541229011932	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
541229011933	dimer interface [polypeptide binding]; other site
541229011934	FMN binding site [chemical binding]; other site
541229011935	Protein of unknown function (DUF3915); Region: DUF3915; pfam13054
541229011936	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
541229011937	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
541229011938	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
541229011939	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
541229011940	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
541229011941	dimerization domain swap beta strand [polypeptide binding]; other site
541229011942	regulatory protein interface [polypeptide binding]; other site
541229011943	active site
541229011944	regulatory phosphorylation site [posttranslational modification]; other site
541229011945	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229011946	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
541229011947	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
541229011948	active site turn [active]
541229011949	phosphorylation site [posttranslational modification]
541229011950	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
541229011951	HPr interaction site; other site
541229011952	glycerol kinase (GK) interaction site [polypeptide binding]; other site
541229011953	active site
541229011954	phosphorylation site [posttranslational modification]
541229011955	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
541229011956	transcriptional antiterminator BglG; Provisional; Region: PRK09772
541229011957	CAT RNA binding domain; Region: CAT_RBD; smart01061
541229011958	PRD domain; Region: PRD; pfam00874
541229011959	PRD domain; Region: PRD; pfam00874
541229011960	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229011961	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229011962	active site
541229011963	motif I; other site
541229011964	motif II; other site
541229011965	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229011966	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
541229011967	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229011968	DNA-binding site [nucleotide binding]; DNA binding site
541229011969	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
541229011970	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
541229011971	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
541229011972	active site
541229011973	trimer interface [polypeptide binding]; other site
541229011974	allosteric site; other site
541229011975	active site lid [active]
541229011976	hexamer (dimer of trimers) interface [polypeptide binding]; other site
541229011977	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
541229011978	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
541229011979	active site
541229011980	dimer interface [polypeptide binding]; other site
541229011981	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
541229011982	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229011983	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
541229011984	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
541229011985	Domain of unknown function (DUF309); Region: DUF309; pfam03745
541229011986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229011987	Coenzyme A binding pocket [chemical binding]; other site
541229011988	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
541229011989	active site
541229011990	Predicted secreted protein [Function unknown]; Region: COG4086
541229011991	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
541229011992	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229011993	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
541229011994	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
541229011995	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229011996	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
541229011997	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
541229011998	stage V sporulation protein AD; Validated; Region: PRK08304
541229011999	stage V sporulation protein AD; Provisional; Region: PRK12404
541229012000	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
541229012001	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
541229012002	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
541229012003	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
541229012004	Na2 binding site [ion binding]; other site
541229012005	putative substrate binding site 1 [chemical binding]; other site
541229012006	Na binding site 1 [ion binding]; other site
541229012007	putative substrate binding site 2 [chemical binding]; other site
541229012008	sporulation sigma factor SigF; Validated; Region: PRK05572
541229012009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229012010	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
541229012011	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229012012	DNA binding residues [nucleotide binding]
541229012013	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
541229012014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229012015	ATP binding site [chemical binding]; other site
541229012016	Mg2+ binding site [ion binding]; other site
541229012017	G-X-G motif; other site
541229012018	anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886
541229012019	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
541229012020	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229012021	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
541229012022	Predicted transcriptional regulators [Transcription]; Region: COG1725
541229012023	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229012024	DNA-binding site [nucleotide binding]; DNA binding site
541229012025	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229012026	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229012027	Walker A/P-loop; other site
541229012028	ATP binding site [chemical binding]; other site
541229012029	Q-loop/lid; other site
541229012030	ABC transporter signature motif; other site
541229012031	Walker B; other site
541229012032	D-loop; other site
541229012033	H-loop/switch region; other site
541229012034	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229012035	MarR family; Region: MarR; pfam01047
541229012036	MarR family; Region: MarR_2; cl17246
541229012037	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
541229012038	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
541229012039	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
541229012040	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
541229012041	oligomer interface [polypeptide binding]; other site
541229012042	metal binding site [ion binding]; metal-binding site
541229012043	metal binding site [ion binding]; metal-binding site
541229012044	putative Cl binding site [ion binding]; other site
541229012045	aspartate ring; other site
541229012046	basic sphincter; other site
541229012047	hydrophobic gate; other site
541229012048	periplasmic entrance; other site
541229012049	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
541229012050	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
541229012051	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
541229012052	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
541229012053	purine nucleoside phosphorylase; Provisional; Region: PRK08202
541229012054	phosphopentomutase; Provisional; Region: PRK05362
541229012055	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
541229012056	YtkA-like; Region: YtkA; pfam13115
541229012057	YtkA-like; Region: YtkA; pfam13115
541229012058	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
541229012059	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
541229012060	active site
541229012061	Int/Topo IB signature motif; other site
541229012062	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
541229012063	ferric uptake regulator; Provisional; Region: fur; PRK09462
541229012064	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
541229012065	metal binding site 2 [ion binding]; metal-binding site
541229012066	putative DNA binding helix; other site
541229012067	metal binding site 1 [ion binding]; metal-binding site
541229012068	dimer interface [polypeptide binding]; other site
541229012069	structural Zn2+ binding site [ion binding]; other site
541229012070	stage II sporulation protein M; Region: spo_II_M; TIGR02831
541229012071	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229012072	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229012073	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
541229012074	dimer interface [polypeptide binding]; other site
541229012075	ADP-ribose binding site [chemical binding]; other site
541229012076	active site
541229012077	nudix motif; other site
541229012078	metal binding site [ion binding]; metal-binding site
541229012079	Protein of unknown function (DUF3936); Region: DUF3936; pfam13072
541229012080	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229012081	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229012082	active site
541229012083	catalytic tetrad [active]
541229012084	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229012085	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229012086	active site
541229012087	catalytic tetrad [active]
541229012088	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
541229012089	Protein of unknown function (DUF3886); Region: DUF3886; pfam13025
541229012090	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
541229012091	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
541229012092	putative active site [active]
541229012093	putative metal binding site [ion binding]; other site
541229012094	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
541229012095	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
541229012096	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229012097	Predicted permease [General function prediction only]; Region: COG2056
541229012098	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
541229012099	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
541229012100	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229012101	Coenzyme A binding pocket [chemical binding]; other site
541229012102	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229012103	Protein of unknown function (DUF2552); Region: DUF2552; pfam10827
541229012104	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
541229012105	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
541229012106	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
541229012107	catalytic motif [active]
541229012108	Zn binding site [ion binding]; other site
541229012109	RibD C-terminal domain; Region: RibD_C; cl17279
541229012110	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
541229012111	Lumazine binding domain; Region: Lum_binding; pfam00677
541229012112	Lumazine binding domain; Region: Lum_binding; pfam00677
541229012113	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
541229012114	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
541229012115	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
541229012116	dimerization interface [polypeptide binding]; other site
541229012117	active site
541229012118	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
541229012119	homopentamer interface [polypeptide binding]; other site
541229012120	active site
541229012121	biotin synthase; Validated; Region: PRK06256
541229012122	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229012123	FeS/SAM binding site; other site
541229012124	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
541229012125	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
541229012126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229012127	S-adenosylmethionine binding site [chemical binding]; other site
541229012128	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229012129	Protein of unknown function (DUF452); Region: DUF452; cl01062
541229012130	TAP-like protein; Region: Abhydrolase_4; pfam08386
541229012131	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
541229012132	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
541229012133	substrate-cofactor binding pocket; other site
541229012134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012135	catalytic residue [active]
541229012136	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
541229012137	AAA domain; Region: AAA_26; pfam13500
541229012138	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
541229012139	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229012140	inhibitor-cofactor binding pocket; inhibition site
541229012141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012142	catalytic residue [active]
541229012143	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
541229012144	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
541229012145	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418
541229012146	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
541229012147	active site
541229012148	metal binding site [ion binding]; metal-binding site
541229012149	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
541229012150	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
541229012151	active site
541229012152	catalytic triad [active]
541229012153	oxyanion hole [active]
541229012154	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229012155	dimerization interface [polypeptide binding]; other site
541229012156	putative DNA binding site [nucleotide binding]; other site
541229012157	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229012158	putative Zn2+ binding site [ion binding]; other site
541229012159	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
541229012160	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
541229012161	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
541229012162	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
541229012163	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
541229012164	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
541229012165	HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410
541229012166	ornithine carbamoyltransferase; Provisional; Region: PRK00779
541229012167	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
541229012168	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
541229012169	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
541229012170	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229012171	inhibitor-cofactor binding pocket; inhibition site
541229012172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012173	catalytic residue [active]
541229012174	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
541229012175	nucleotide binding site [chemical binding]; other site
541229012176	N-acetyl-L-glutamate binding site [chemical binding]; other site
541229012177	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
541229012178	heterotetramer interface [polypeptide binding]; other site
541229012179	active site pocket [active]
541229012180	cleavage site
541229012181	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
541229012182	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
541229012183	YqzH-like protein; Region: YqzH; pfam14164
541229012184	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
541229012185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229012186	NAD(P) binding site [chemical binding]; other site
541229012187	active site
541229012188	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229012189	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679
541229012190	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
541229012191	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
541229012192	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
541229012193	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
541229012194	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
541229012195	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
541229012196	putative L-serine binding site [chemical binding]; other site
541229012197	ribonuclease Z; Region: RNase_Z; TIGR02651
541229012198	Protein of unknown function (DUF3932); Region: DUF3932; pfam13068
541229012199	magnesium-transporting ATPase; Provisional; Region: PRK15122
541229012200	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
541229012201	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
541229012202	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
541229012203	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
541229012204	Soluble P-type ATPase [General function prediction only]; Region: COG4087
541229012205	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
541229012206	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
541229012207	MgtC family; Region: MgtC; pfam02308
541229012208	DNA polymerase IV; Validated; Region: PRK01810
541229012209	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
541229012210	active site
541229012211	DNA binding site [nucleotide binding]
541229012212	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
541229012213	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
541229012214	peptidase T-like protein; Region: PepT-like; TIGR01883
541229012215	metal binding site [ion binding]; metal-binding site
541229012216	putative dimer interface [polypeptide binding]; other site
541229012217	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229012218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229012219	Protein of unknown function (DUF3894); Region: DUF3894; pfam13033
541229012220	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
541229012221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
541229012222	Predicted membrane protein [Function unknown]; Region: COG4129
541229012223	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
541229012224	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
541229012225	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
541229012226	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
541229012227	Walker A/P-loop; other site
541229012228	ATP binding site [chemical binding]; other site
541229012229	Q-loop/lid; other site
541229012230	ABC transporter signature motif; other site
541229012231	Walker B; other site
541229012232	D-loop; other site
541229012233	H-loop/switch region; other site
541229012234	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
541229012235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229012236	dimer interface [polypeptide binding]; other site
541229012237	conserved gate region; other site
541229012238	putative PBP binding loops; other site
541229012239	ABC-ATPase subunit interface; other site
541229012240	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
541229012241	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
541229012242	substrate binding pocket [chemical binding]; other site
541229012243	membrane-bound complex binding site; other site
541229012244	hinge residues; other site
541229012245	Disulphide isomerase; Region: Disulph_isomer; pfam06491
541229012246	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
541229012247	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
541229012248	nudix motif; other site
541229012249	Predicted membrane protein [Function unknown]; Region: COG2323
541229012250	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
541229012251	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
541229012252	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
541229012253	E3 interaction surface; other site
541229012254	lipoyl attachment site [posttranslational modification]; other site
541229012255	e3 binding domain; Region: E3_binding; pfam02817
541229012256	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
541229012257	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
541229012258	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
541229012259	alpha subunit interface [polypeptide binding]; other site
541229012260	TPP binding site [chemical binding]; other site
541229012261	heterodimer interface [polypeptide binding]; other site
541229012262	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
541229012263	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
541229012264	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
541229012265	tetramer interface [polypeptide binding]; other site
541229012266	TPP-binding site [chemical binding]; other site
541229012267	heterodimer interface [polypeptide binding]; other site
541229012268	phosphorylation loop region [posttranslational modification]
541229012269	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
541229012270	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
541229012271	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229012272	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
541229012273	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
541229012274	nucleotide binding site [chemical binding]; other site
541229012275	Acetokinase family; Region: Acetate_kinase; cl17229
541229012276	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
541229012277	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
541229012278	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
541229012279	NAD binding site [chemical binding]; other site
541229012280	Phe binding site; other site
541229012281	phosphate butyryltransferase; Validated; Region: PRK07742
541229012282	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
541229012283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229012284	putative active site [active]
541229012285	heme pocket [chemical binding]; other site
541229012286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229012287	putative active site [active]
541229012288	heme pocket [chemical binding]; other site
541229012289	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229012290	Walker A motif; other site
541229012291	ATP binding site [chemical binding]; other site
541229012292	Walker B motif; other site
541229012293	arginine finger; other site
541229012294	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
541229012295	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
541229012296	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
541229012297	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
541229012298	active site
541229012299	catalytic site [active]
541229012300	metal binding site [ion binding]; metal-binding site
541229012301	dimer interface [polypeptide binding]; other site
541229012302	YycC-like protein; Region: YycC; pfam14174
541229012303	hypothetical protein; Provisional; Region: PRK06770
541229012304	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
541229012305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229012306	active site
541229012307	phosphorylation site [posttranslational modification]
541229012308	intermolecular recognition site; other site
541229012309	dimerization interface [polypeptide binding]; other site
541229012310	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
541229012311	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
541229012312	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
541229012313	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
541229012314	potential frameshift: common BLAST hit: gi|218231559|ref|YP_002368977.1| DNA repair protein RecN
541229012315	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
541229012316	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
541229012317	ABC transporter signature motif; other site
541229012318	Walker B; other site
541229012319	D-loop; other site
541229012320	H-loop/switch region; other site
541229012321	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
541229012322	Walker A/P-loop; other site
541229012323	ATP binding site [chemical binding]; other site
541229012324	Q-loop/lid; other site
541229012325	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
541229012326	arginine repressor; Provisional; Region: PRK04280
541229012327	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
541229012328	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
541229012329	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229012330	RNA binding surface [nucleotide binding]; other site
541229012331	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
541229012332	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
541229012333	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
541229012334	TPP-binding site; other site
541229012335	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
541229012336	PYR/PP interface [polypeptide binding]; other site
541229012337	dimer interface [polypeptide binding]; other site
541229012338	TPP binding site [chemical binding]; other site
541229012339	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
541229012340	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
541229012341	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
541229012342	substrate binding pocket [chemical binding]; other site
541229012343	chain length determination region; other site
541229012344	substrate-Mg2+ binding site; other site
541229012345	catalytic residues [active]
541229012346	aspartate-rich region 1; other site
541229012347	active site lid residues [active]
541229012348	aspartate-rich region 2; other site
541229012349	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063
541229012350	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
541229012351	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
541229012352	generic binding surface II; other site
541229012353	generic binding surface I; other site
541229012354	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
541229012355	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
541229012356	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
541229012357	homodimer interface [polypeptide binding]; other site
541229012358	NADP binding site [chemical binding]; other site
541229012359	substrate binding site [chemical binding]; other site
541229012360	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
541229012361	putative RNA binding site [nucleotide binding]; other site
541229012362	Asp23 family; Region: Asp23; pfam03780
541229012363	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
541229012364	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
541229012365	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
541229012366	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
541229012367	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
541229012368	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
541229012369	carboxyltransferase (CT) interaction site; other site
541229012370	biotinylation site [posttranslational modification]; other site
541229012371	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
541229012372	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
541229012373	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
541229012374	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
541229012375	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
541229012376	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
541229012377	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
541229012378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229012379	Walker A motif; other site
541229012380	ATP binding site [chemical binding]; other site
541229012381	Walker B motif; other site
541229012382	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
541229012383	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229012384	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229012385	elongation factor P; Validated; Region: PRK00529
541229012386	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
541229012387	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
541229012388	RNA binding site [nucleotide binding]; other site
541229012389	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
541229012390	RNA binding site [nucleotide binding]; other site
541229012391	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
541229012392	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
541229012393	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
541229012394	active site
541229012395	Dehydroquinase class II; Region: DHquinase_II; pfam01220
541229012396	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
541229012397	trimer interface [polypeptide binding]; other site
541229012398	active site
541229012399	dimer interface [polypeptide binding]; other site
541229012400	Conserved membrane protein YqhR; Region: YqhR; pfam11085
541229012401	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
541229012402	Carbon starvation protein CstA; Region: CstA; pfam02554
541229012403	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
541229012404	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
541229012405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229012406	motif II; other site
541229012407	manganese transport transcriptional regulator; Provisional; Region: PRK03902
541229012408	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
541229012409	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
541229012410	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
541229012411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229012412	FeS/SAM binding site; other site
541229012413	Predicted transcriptional regulators [Transcription]; Region: COG1695
541229012414	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
541229012415	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
541229012416	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
541229012417	active site residue [active]
541229012418	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229012419	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229012420	DNA binding site [nucleotide binding]
541229012421	domain linker motif; other site
541229012422	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
541229012423	putative dimerization interface [polypeptide binding]; other site
541229012424	putative ligand binding site [chemical binding]; other site
541229012425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229012426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229012427	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229012428	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229012429	Protein of unknown function (DUF3975); Region: DUF3975; pfam13126
541229012430	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
541229012431	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
541229012432	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
541229012433	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229012434	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229012435	Walker A/P-loop; other site
541229012436	ATP binding site [chemical binding]; other site
541229012437	Q-loop/lid; other site
541229012438	ABC transporter signature motif; other site
541229012439	Walker B; other site
541229012440	D-loop; other site
541229012441	H-loop/switch region; other site
541229012442	Predicted transcriptional regulators [Transcription]; Region: COG1725
541229012443	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229012444	DNA-binding site [nucleotide binding]; DNA binding site
541229012445	Protein of unknown function (DUF3929); Region: DUF3929; pfam13066
541229012446	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
541229012447	tetramer interface [polypeptide binding]; other site
541229012448	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012449	catalytic residue [active]
541229012450	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
541229012451	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
541229012452	tetramer interface [polypeptide binding]; other site
541229012453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012454	catalytic residue [active]
541229012455	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
541229012456	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
541229012457	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
541229012458	DEAD-like helicases superfamily; Region: DEXDc; smart00487
541229012459	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229012460	ATP binding site [chemical binding]; other site
541229012461	putative Mg++ binding site [ion binding]; other site
541229012462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229012463	nucleotide binding region [chemical binding]; other site
541229012464	ATP-binding site [chemical binding]; other site
541229012465	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
541229012466	YqzE-like protein; Region: YqzE; pfam14038
541229012467	Shikimate kinase; Region: SKI; pfam01202
541229012468	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
541229012469	ADP binding site [chemical binding]; other site
541229012470	magnesium binding site [ion binding]; other site
541229012471	putative shikimate binding site; other site
541229012472	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
541229012473	ComG operon protein 7; Region: ComGG; pfam14173
541229012474	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
541229012475	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
541229012476	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
541229012477	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
541229012478	Type II/IV secretion system protein; Region: T2SE; pfam00437
541229012479	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
541229012480	Walker A motif; other site
541229012481	ATP binding site [chemical binding]; other site
541229012482	Walker B motif; other site
541229012483	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229012484	putative DNA binding site [nucleotide binding]; other site
541229012485	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
541229012486	putative Zn2+ binding site [ion binding]; other site
541229012487	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
541229012488	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
541229012489	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
541229012490	Protein of unknown function (DUF3912); Region: DUF3912; pfam13051
541229012491	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
541229012492	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
541229012493	Protein of unknown function (DUF3966); Region: DUF3966; pfam13110
541229012494	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
541229012495	homodimer interface [polypeptide binding]; other site
541229012496	active site
541229012497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229012498	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229012499	Probable transposase; Region: OrfB_IS605; pfam01385
541229012500	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
541229012501	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
541229012502	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
541229012503	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
541229012504	substrate binding pocket [chemical binding]; other site
541229012505	dimer interface [polypeptide binding]; other site
541229012506	inhibitor binding site; inhibition site
541229012507	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
541229012508	B12 binding site [chemical binding]; other site
541229012509	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
541229012510	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
541229012511	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
541229012512	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
541229012513	FAD binding site [chemical binding]; other site
541229012514	cystathionine gamma-synthase; Reviewed; Region: PRK08247
541229012515	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
541229012516	homodimer interface [polypeptide binding]; other site
541229012517	substrate-cofactor binding pocket; other site
541229012518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012519	catalytic residue [active]
541229012520	cystathionine beta-lyase; Provisional; Region: PRK08064
541229012521	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
541229012522	homodimer interface [polypeptide binding]; other site
541229012523	substrate-cofactor binding pocket; other site
541229012524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012525	catalytic residue [active]
541229012526	Isochorismatase family; Region: Isochorismatase; pfam00857
541229012527	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
541229012528	catalytic triad [active]
541229012529	conserved cis-peptide bond; other site
541229012530	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229012531	dimerization interface [polypeptide binding]; other site
541229012532	putative DNA binding site [nucleotide binding]; other site
541229012533	putative Zn2+ binding site [ion binding]; other site
541229012534	Uncharacterized conserved protein [Function unknown]; Region: COG1565
541229012535	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
541229012536	Protein of unknown function (DUF2759); Region: DUF2759; pfam10958
541229012537	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
541229012538	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
541229012539	nucleotide binding site [chemical binding]; other site
541229012540	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
541229012541	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
541229012542	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
541229012543	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
541229012544	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
541229012545	active site
541229012546	Substrate binding site; other site
541229012547	Mg++ binding site; other site
541229012548	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
541229012549	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
541229012550	active site
541229012551	metal binding site [ion binding]; metal-binding site
541229012552	substrate binding site [chemical binding]; other site
541229012553	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
541229012554	PhoU domain; Region: PhoU; pfam01895
541229012555	PhoU domain; Region: PhoU; pfam01895
541229012556	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
541229012557	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
541229012558	Walker A/P-loop; other site
541229012559	ATP binding site [chemical binding]; other site
541229012560	Q-loop/lid; other site
541229012561	ABC transporter signature motif; other site
541229012562	Walker B; other site
541229012563	D-loop; other site
541229012564	H-loop/switch region; other site
541229012565	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
541229012566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229012567	dimer interface [polypeptide binding]; other site
541229012568	conserved gate region; other site
541229012569	putative PBP binding loops; other site
541229012570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
541229012571	ABC-ATPase subunit interface; other site
541229012572	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
541229012573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229012574	dimer interface [polypeptide binding]; other site
541229012575	conserved gate region; other site
541229012576	putative PBP binding loops; other site
541229012577	ABC-ATPase subunit interface; other site
541229012578	PBP superfamily domain; Region: PBP_like_2; cl17296
541229012579	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229012580	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229012581	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229012582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229012583	putative substrate translocation pore; other site
541229012584	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229012585	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
541229012586	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
541229012587	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
541229012588	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
541229012589	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
541229012590	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
541229012591	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
541229012592	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
541229012593	metal binding site 2 [ion binding]; metal-binding site
541229012594	putative DNA binding helix; other site
541229012595	metal binding site 1 [ion binding]; metal-binding site
541229012596	dimer interface [polypeptide binding]; other site
541229012597	structural Zn2+ binding site [ion binding]; other site
541229012598	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
541229012599	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229012600	ABC-ATPase subunit  interface; other site
541229012601	dimer interface [polypeptide binding]; other site
541229012602	putative PBP binding regions; other site
541229012603	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
541229012604	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
541229012605	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229012606	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229012607	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229012608	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229012609	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
541229012610	endonuclease IV; Provisional; Region: PRK01060
541229012611	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
541229012612	AP (apurinic/apyrimidinic) site pocket; other site
541229012613	DNA interaction; other site
541229012614	Metal-binding active site; metal-binding site
541229012615	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
541229012616	DEAD-like helicases superfamily; Region: DEXDc; smart00487
541229012617	ATP binding site [chemical binding]; other site
541229012618	Mg++ binding site [ion binding]; other site
541229012619	motif III; other site
541229012620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229012621	nucleotide binding region [chemical binding]; other site
541229012622	ATP-binding site [chemical binding]; other site
541229012623	YqfQ-like protein; Region: YqfQ; pfam14181
541229012624	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
541229012625	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
541229012626	Uncharacterized conserved protein [Function unknown]; Region: COG0327
541229012627	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
541229012628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
541229012629	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
541229012630	Uncharacterized conserved protein [Function unknown]; Region: COG0327
541229012631	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
541229012632	Family of unknown function (DUF633); Region: DUF633; pfam04816
541229012633	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
541229012634	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
541229012635	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
541229012636	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
541229012637	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
541229012638	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229012639	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
541229012640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229012641	DNA binding residues [nucleotide binding]
541229012642	DNA primase; Validated; Region: dnaG; PRK05667
541229012643	CHC2 zinc finger; Region: zf-CHC2; pfam01807
541229012644	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
541229012645	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
541229012646	active site
541229012647	metal binding site [ion binding]; metal-binding site
541229012648	interdomain interaction site; other site
541229012649	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
541229012650	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
541229012651	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
541229012652	PEP synthetase regulatory protein; Provisional; Region: PRK05339
541229012653	HTH domain; Region: HTH_11; pfam08279
541229012654	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
541229012655	FOG: CBS domain [General function prediction only]; Region: COG0517
541229012656	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
541229012657	Recombination protein O N terminal; Region: RecO_N; pfam11967
541229012658	Recombination protein O C terminal; Region: RecO_C; pfam02565
541229012659	YqzL-like protein; Region: YqzL; pfam14006
541229012660	GTPase Era; Reviewed; Region: era; PRK00089
541229012661	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
541229012662	G1 box; other site
541229012663	GTP/Mg2+ binding site [chemical binding]; other site
541229012664	Switch I region; other site
541229012665	G2 box; other site
541229012666	Switch II region; other site
541229012667	G3 box; other site
541229012668	G4 box; other site
541229012669	G5 box; other site
541229012670	KH domain; Region: KH_2; pfam07650
541229012671	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
541229012672	active site
541229012673	catalytic motif [active]
541229012674	Zn binding site [ion binding]; other site
541229012675	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
541229012676	metal-binding heat shock protein; Provisional; Region: PRK00016
541229012677	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
541229012678	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
541229012679	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229012680	Zn2+ binding site [ion binding]; other site
541229012681	Mg2+ binding site [ion binding]; other site
541229012682	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
541229012683	PhoH-like protein; Region: PhoH; pfam02562
541229012684	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
541229012685	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
541229012686	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
541229012687	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
541229012688	Yqey-like protein; Region: YqeY; pfam09424
541229012689	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
541229012690	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
541229012691	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
541229012692	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229012693	FeS/SAM binding site; other site
541229012694	TRAM domain; Region: TRAM; cl01282
541229012695	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
541229012696	RNA methyltransferase, RsmE family; Region: TIGR00046
541229012697	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
541229012698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229012699	S-adenosylmethionine binding site [chemical binding]; other site
541229012700	chaperone protein DnaJ; Provisional; Region: PRK14280
541229012701	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
541229012702	HSP70 interaction site [polypeptide binding]; other site
541229012703	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
541229012704	substrate binding site [polypeptide binding]; other site
541229012705	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
541229012706	Zn binding sites [ion binding]; other site
541229012707	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
541229012708	dimer interface [polypeptide binding]; other site
541229012709	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
541229012710	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
541229012711	nucleotide binding site [chemical binding]; other site
541229012712	NEF interaction site [polypeptide binding]; other site
541229012713	SBD interface [polypeptide binding]; other site
541229012714	GrpE; Region: GrpE; pfam01025
541229012715	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
541229012716	dimer interface [polypeptide binding]; other site
541229012717	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
541229012718	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
541229012719	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
541229012720	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
541229012721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229012722	FeS/SAM binding site; other site
541229012723	HemN C-terminal domain; Region: HemN_C; pfam06969
541229012724	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229012725	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
541229012726	GTP-binding protein LepA; Provisional; Region: PRK05433
541229012727	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
541229012728	G1 box; other site
541229012729	putative GEF interaction site [polypeptide binding]; other site
541229012730	GTP/Mg2+ binding site [chemical binding]; other site
541229012731	Switch I region; other site
541229012732	G2 box; other site
541229012733	G3 box; other site
541229012734	Switch II region; other site
541229012735	G4 box; other site
541229012736	G5 box; other site
541229012737	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
541229012738	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
541229012739	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
541229012740	Protein of unknown function (DUF3679); Region: DUF3679; pfam12438
541229012741	germination protease; Provisional; Region: PRK02858
541229012742	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
541229012743	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
541229012744	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
541229012745	YqzM-like protein; Region: YqzM; pfam14141
541229012746	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
541229012747	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
541229012748	Competence protein; Region: Competence; pfam03772
541229012749	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229012750	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
541229012751	catalytic motif [active]
541229012752	Zn binding site [ion binding]; other site
541229012753	SLBB domain; Region: SLBB; pfam10531
541229012754	comEA protein; Region: comE; TIGR01259
541229012755	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
541229012756	late competence protein ComER; Validated; Region: PRK07680
541229012757	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
541229012758	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
541229012759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229012760	S-adenosylmethionine binding site [chemical binding]; other site
541229012761	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
541229012762	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
541229012763	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229012764	Zn2+ binding site [ion binding]; other site
541229012765	Mg2+ binding site [ion binding]; other site
541229012766	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
541229012767	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
541229012768	active site
541229012769	(T/H)XGH motif; other site
541229012770	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
541229012771	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
541229012772	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
541229012773	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
541229012774	shikimate binding site; other site
541229012775	NAD(P) binding site [chemical binding]; other site
541229012776	GTPase YqeH; Provisional; Region: PRK13796
541229012777	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
541229012778	GTP/Mg2+ binding site [chemical binding]; other site
541229012779	G4 box; other site
541229012780	G5 box; other site
541229012781	G1 box; other site
541229012782	Switch I region; other site
541229012783	G2 box; other site
541229012784	G3 box; other site
541229012785	Switch II region; other site
541229012786	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
541229012787	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229012788	active site
541229012789	motif I; other site
541229012790	motif II; other site
541229012791	Sporulation inhibitor A; Region: Sda; pfam08970
541229012792	phosphatidylserine decarboxylase; Provisional; Region: PRK03140
541229012793	sporulation sigma factor SigK; Reviewed; Region: PRK05803
541229012794	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229012795	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229012796	DNA binding residues [nucleotide binding]
541229012797	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
541229012798	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
541229012799	dimer interface [polypeptide binding]; other site
541229012800	FMN binding site [chemical binding]; other site
541229012801	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
541229012802	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
541229012803	synthetase active site [active]
541229012804	NTP binding site [chemical binding]; other site
541229012805	metal binding site [ion binding]; metal-binding site
541229012806	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
541229012807	dimer interface [polypeptide binding]; other site
541229012808	Alkaline phosphatase homologues; Region: alkPPc; smart00098
541229012809	active site
541229012810	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229012811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229012812	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229012813	Coenzyme A binding pocket [chemical binding]; other site
541229012814	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229012815	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229012816	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
541229012817	catalytic site [active]
541229012818	DoxX; Region: DoxX; cl17842
541229012819	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
541229012820	catalytic core [active]
541229012821	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
541229012822	translocation protein TolB; Provisional; Region: tolB; PRK04792
541229012823	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
541229012824	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
541229012825	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
541229012826	putative active site [active]
541229012827	catalytic triad [active]
541229012828	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
541229012829	putative integrin binding motif; other site
541229012830	PA/protease domain interface [polypeptide binding]; other site
541229012831	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
541229012832	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
541229012833	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
541229012834	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
541229012835	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
541229012836	cofactor binding site; other site
541229012837	metal binding site [ion binding]; metal-binding site
541229012838	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
541229012839	aromatic arch; other site
541229012840	DCoH dimer interaction site [polypeptide binding]; other site
541229012841	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
541229012842	DCoH tetramer interaction site [polypeptide binding]; other site
541229012843	substrate binding site [chemical binding]; other site
541229012844	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
541229012845	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
541229012846	putative metal binding site [ion binding]; other site
541229012847	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
541229012848	active site
541229012849	Predicted membrane protein [Function unknown]; Region: COG2259
541229012850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229012851	non-specific DNA binding site [nucleotide binding]; other site
541229012852	salt bridge; other site
541229012853	sequence-specific DNA binding site [nucleotide binding]; other site
541229012854	Cupin domain; Region: Cupin_2; pfam07883
541229012855	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
541229012856	active site 2 [active]
541229012857	active site 1 [active]
541229012858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229012859	Coenzyme A binding pocket [chemical binding]; other site
541229012860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229012861	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229012862	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
541229012863	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
541229012864	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
541229012865	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
541229012866	Walker A/P-loop; other site
541229012867	ATP binding site [chemical binding]; other site
541229012868	Q-loop/lid; other site
541229012869	ABC transporter signature motif; other site
541229012870	Walker B; other site
541229012871	D-loop; other site
541229012872	H-loop/switch region; other site
541229012873	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
541229012874	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229012875	ABC-ATPase subunit  interface; other site
541229012876	dimer interface [polypeptide binding]; other site
541229012877	putative PBP binding regions; other site
541229012878	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
541229012879	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
541229012880	intersubunit interface [polypeptide binding]; other site
541229012881	YrhC-like protein; Region: YrhC; pfam14143
541229012882	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
541229012883	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
541229012884	putative catalytic cysteine [active]
541229012885	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
541229012886	putative active site [active]
541229012887	metal binding site [ion binding]; metal-binding site
541229012888	cystathionine beta-lyase; Provisional; Region: PRK07671
541229012889	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
541229012890	homodimer interface [polypeptide binding]; other site
541229012891	substrate-cofactor binding pocket; other site
541229012892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012893	catalytic residue [active]
541229012894	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
541229012895	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
541229012896	dimer interface [polypeptide binding]; other site
541229012897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229012898	catalytic residue [active]
541229012899	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
541229012900	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
541229012901	Methyltransferase domain; Region: Methyltransf_23; pfam13489
541229012902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229012903	S-adenosylmethionine binding site [chemical binding]; other site
541229012904	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
541229012905	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
541229012906	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
541229012907	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
541229012908	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229012909	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
541229012910	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
541229012911	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
541229012912	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
541229012913	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
541229012914	ATP-binding site [chemical binding]; other site
541229012915	Sugar specificity; other site
541229012916	Pyrimidine base specificity; other site
541229012917	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
541229012918	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
541229012919	Peptidase family U32; Region: Peptidase_U32; pfam01136
541229012920	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
541229012921	Protein of unknown function (DUF556); Region: DUF556; cl00822
541229012922	Peptidase family U32; Region: Peptidase_U32; pfam01136
541229012923	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
541229012924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229012925	S-adenosylmethionine binding site [chemical binding]; other site
541229012926	YceG-like family; Region: YceG; pfam02618
541229012927	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
541229012928	dimerization interface [polypeptide binding]; other site
541229012929	hypothetical protein; Provisional; Region: PRK13678
541229012930	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
541229012931	hypothetical protein; Provisional; Region: PRK05473
541229012932	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
541229012933	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
541229012934	motif 1; other site
541229012935	active site
541229012936	motif 2; other site
541229012937	motif 3; other site
541229012938	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
541229012939	DHHA1 domain; Region: DHHA1; pfam02272
541229012940	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
541229012941	Domain of unknown function DUF20; Region: UPF0118; pfam01594
541229012942	Protein of unknown function (DUF3918); Region: DUF3918; pfam13056
541229012943	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
541229012944	AAA domain; Region: AAA_30; pfam13604
541229012945	Family description; Region: UvrD_C_2; pfam13538
541229012946	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229012947	TPR motif; other site
541229012948	binding surface
541229012949	TPR repeat; Region: TPR_11; pfam13414
541229012950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229012951	binding surface
541229012952	TPR motif; other site
541229012953	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229012954	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229012955	binding surface
541229012956	TPR motif; other site
541229012957	TPR repeat; Region: TPR_11; pfam13414
541229012958	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
541229012959	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
541229012960	Ligand Binding Site [chemical binding]; other site
541229012961	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
541229012962	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
541229012963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229012964	catalytic residue [active]
541229012965	Predicted transcriptional regulator [Transcription]; Region: COG1959
541229012966	Transcriptional regulator; Region: Rrf2; pfam02082
541229012967	recombination factor protein RarA; Reviewed; Region: PRK13342
541229012968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229012969	Walker A motif; other site
541229012970	ATP binding site [chemical binding]; other site
541229012971	Walker B motif; other site
541229012972	arginine finger; other site
541229012973	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
541229012974	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
541229012975	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
541229012976	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
541229012977	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
541229012978	putative ATP binding site [chemical binding]; other site
541229012979	putative substrate interface [chemical binding]; other site
541229012980	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
541229012981	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
541229012982	dimer interface [polypeptide binding]; other site
541229012983	anticodon binding site; other site
541229012984	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
541229012985	homodimer interface [polypeptide binding]; other site
541229012986	motif 1; other site
541229012987	active site
541229012988	motif 2; other site
541229012989	GAD domain; Region: GAD; pfam02938
541229012990	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
541229012991	motif 3; other site
541229012992	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
541229012993	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
541229012994	dimer interface [polypeptide binding]; other site
541229012995	motif 1; other site
541229012996	active site
541229012997	motif 2; other site
541229012998	motif 3; other site
541229012999	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
541229013000	anticodon binding site; other site
541229013001	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
541229013002	putative active site [active]
541229013003	dimerization interface [polypeptide binding]; other site
541229013004	putative tRNAtyr binding site [nucleotide binding]; other site
541229013005	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
541229013006	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229013007	Zn2+ binding site [ion binding]; other site
541229013008	Mg2+ binding site [ion binding]; other site
541229013009	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
541229013010	synthetase active site [active]
541229013011	NTP binding site [chemical binding]; other site
541229013012	metal binding site [ion binding]; metal-binding site
541229013013	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
541229013014	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
541229013015	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229013016	active site
541229013017	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
541229013018	DHH family; Region: DHH; pfam01368
541229013019	DHHA1 domain; Region: DHHA1; pfam02272
541229013020	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
541229013021	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
541229013022	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
541229013023	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
541229013024	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
541229013025	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
541229013026	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
541229013027	Protein export membrane protein; Region: SecD_SecF; pfam02355
541229013028	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
541229013029	stage V sporulation protein B; Region: spore_V_B; TIGR02900
541229013030	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
541229013031	Predicted membrane protein [Function unknown]; Region: COG2323
541229013032	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
541229013033	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
541229013034	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
541229013035	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
541229013036	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
541229013037	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
541229013038	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
541229013039	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
541229013040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229013041	Walker A motif; other site
541229013042	ATP binding site [chemical binding]; other site
541229013043	Walker B motif; other site
541229013044	arginine finger; other site
541229013045	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
541229013046	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
541229013047	RuvA N terminal domain; Region: RuvA_N; pfam01330
541229013048	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
541229013049	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
541229013050	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
541229013051	putative ligand binding residues [chemical binding]; other site
541229013052	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
541229013053	BofC C-terminal domain; Region: BofC_C; pfam08955
541229013054	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
541229013055	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229013056	quinolinate synthetase; Provisional; Region: PRK09375
541229013057	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
541229013058	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
541229013059	dimerization interface [polypeptide binding]; other site
541229013060	active site
541229013061	L-aspartate oxidase; Provisional; Region: PRK08071
541229013062	L-aspartate oxidase; Provisional; Region: PRK06175
541229013063	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
541229013064	cysteine desulfurase; Provisional; Region: PRK02948
541229013065	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
541229013066	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229013067	catalytic residue [active]
541229013068	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
541229013069	HTH domain; Region: HTH_11; pfam08279
541229013070	3H domain; Region: 3H; pfam02829
541229013071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
541229013072	MOSC domain; Region: MOSC; pfam03473
541229013073	3-alpha domain; Region: 3-alpha; pfam03475
541229013074	prephenate dehydratase; Provisional; Region: PRK11898
541229013075	Prephenate dehydratase; Region: PDT; pfam00800
541229013076	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
541229013077	putative L-Phe binding site [chemical binding]; other site
541229013078	FtsX-like permease family; Region: FtsX; pfam02687
541229013079	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229013080	FtsX-like permease family; Region: FtsX; pfam02687
541229013081	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229013082	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229013083	Walker A/P-loop; other site
541229013084	ATP binding site [chemical binding]; other site
541229013085	Q-loop/lid; other site
541229013086	ABC transporter signature motif; other site
541229013087	Walker B; other site
541229013088	D-loop; other site
541229013089	H-loop/switch region; other site
541229013090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229013091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
541229013092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229013093	ATP binding site [chemical binding]; other site
541229013094	Mg2+ binding site [ion binding]; other site
541229013095	G-X-G motif; other site
541229013096	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229013097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229013098	active site
541229013099	phosphorylation site [posttranslational modification]
541229013100	intermolecular recognition site; other site
541229013101	dimerization interface [polypeptide binding]; other site
541229013102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229013103	DNA binding site [nucleotide binding]
541229013104	GTPase CgtA; Reviewed; Region: obgE; PRK12297
541229013105	GTP1/OBG; Region: GTP1_OBG; pfam01018
541229013106	Obg GTPase; Region: Obg; cd01898
541229013107	G1 box; other site
541229013108	GTP/Mg2+ binding site [chemical binding]; other site
541229013109	Switch I region; other site
541229013110	G2 box; other site
541229013111	G3 box; other site
541229013112	Switch II region; other site
541229013113	G4 box; other site
541229013114	G5 box; other site
541229013115	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
541229013116	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
541229013117	hypothetical protein; Provisional; Region: PRK14553
541229013118	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
541229013119	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
541229013120	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
541229013121	homodimer interface [polypeptide binding]; other site
541229013122	oligonucleotide binding site [chemical binding]; other site
541229013123	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
541229013124	Peptidase family M50; Region: Peptidase_M50; pfam02163
541229013125	active site
541229013126	putative substrate binding region [chemical binding]; other site
541229013127	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229013128	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229013129	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
541229013130	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
541229013131	Switch I; other site
541229013132	Switch II; other site
541229013133	septum formation inhibitor; Reviewed; Region: minC; PRK00513
541229013134	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
541229013135	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
541229013136	rod shape-determining protein MreC; Provisional; Region: PRK13922
541229013137	rod shape-determining protein MreC; Region: MreC; pfam04085
541229013138	rod shape-determining protein MreB; Provisional; Region: PRK13927
541229013139	MreB and similar proteins; Region: MreB_like; cd10225
541229013140	nucleotide binding site [chemical binding]; other site
541229013141	Mg binding site [ion binding]; other site
541229013142	putative protofilament interaction site [polypeptide binding]; other site
541229013143	RodZ interaction site [polypeptide binding]; other site
541229013144	hypothetical protein; Reviewed; Region: PRK00024
541229013145	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
541229013146	MPN+ (JAMM) motif; other site
541229013147	Zinc-binding site [ion binding]; other site
541229013148	Maf-like protein; Region: Maf; pfam02545
541229013149	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
541229013150	active site
541229013151	dimer interface [polypeptide binding]; other site
541229013152	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
541229013153	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
541229013154	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
541229013155	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
541229013156	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
541229013157	active site
541229013158	HIGH motif; other site
541229013159	nucleotide binding site [chemical binding]; other site
541229013160	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
541229013161	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
541229013162	active site
541229013163	KMSKS motif; other site
541229013164	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
541229013165	tRNA binding surface [nucleotide binding]; other site
541229013166	anticodon binding site; other site
541229013167	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
541229013168	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
541229013169	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
541229013170	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
541229013171	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
541229013172	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
541229013173	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
541229013174	inhibitor-cofactor binding pocket; inhibition site
541229013175	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229013176	catalytic residue [active]
541229013177	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
541229013178	dimer interface [polypeptide binding]; other site
541229013179	active site
541229013180	Schiff base residues; other site
541229013181	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
541229013182	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
541229013183	active site
541229013184	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
541229013185	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
541229013186	domain interfaces; other site
541229013187	active site
541229013188	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
541229013189	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
541229013190	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
541229013191	tRNA; other site
541229013192	putative tRNA binding site [nucleotide binding]; other site
541229013193	putative NADP binding site [chemical binding]; other site
541229013194	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
541229013195	Transcriptional regulators [Transcription]; Region: MarR; COG1846
541229013196	MarR family; Region: MarR; pfam01047
541229013197	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
541229013198	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
541229013199	G1 box; other site
541229013200	GTP/Mg2+ binding site [chemical binding]; other site
541229013201	Switch I region; other site
541229013202	G2 box; other site
541229013203	G3 box; other site
541229013204	Switch II region; other site
541229013205	G4 box; other site
541229013206	G5 box; other site
541229013207	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
541229013208	Found in ATP-dependent protease La (LON); Region: LON; smart00464
541229013209	Found in ATP-dependent protease La (LON); Region: LON; smart00464
541229013210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229013211	Walker A motif; other site
541229013212	ATP binding site [chemical binding]; other site
541229013213	Walker B motif; other site
541229013214	arginine finger; other site
541229013215	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
541229013216	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
541229013217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229013218	Walker A motif; other site
541229013219	ATP binding site [chemical binding]; other site
541229013220	Walker B motif; other site
541229013221	arginine finger; other site
541229013222	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
541229013223	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
541229013224	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
541229013225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229013226	Walker A motif; other site
541229013227	ATP binding site [chemical binding]; other site
541229013228	Walker B motif; other site
541229013229	arginine finger; other site
541229013230	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
541229013231	trigger factor; Provisional; Region: tig; PRK01490
541229013232	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
541229013233	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
541229013234	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
541229013235	pentamer interface [polypeptide binding]; other site
541229013236	dodecaamer interface [polypeptide binding]; other site
541229013237	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
541229013238	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229013239	non-specific DNA binding site [nucleotide binding]; other site
541229013240	salt bridge; other site
541229013241	sequence-specific DNA binding site [nucleotide binding]; other site
541229013242	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
541229013243	Helix-turn-helix domain; Region: HTH_36; pfam13730
541229013244	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
541229013245	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
541229013246	catalytic residues [active]
541229013247	catalytic nucleophile [active]
541229013248	Presynaptic Site I dimer interface [polypeptide binding]; other site
541229013249	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
541229013250	Synaptic Flat tetramer interface [polypeptide binding]; other site
541229013251	Synaptic Site I dimer interface [polypeptide binding]; other site
541229013252	DNA binding site [nucleotide binding]
541229013253	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
541229013254	trimer interface [polypeptide binding]; other site
541229013255	active site
541229013256	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229013257	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
541229013258	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229013259	active site
541229013260	catalytic residues [active]
541229013261	DNA binding site [nucleotide binding]
541229013262	Int/Topo IB signature motif; other site
541229013263	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
541229013264	active site
541229013265	metal binding site [ion binding]; metal-binding site
541229013266	homotetramer interface [polypeptide binding]; other site
541229013267	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
541229013268	active site
541229013269	dimerization interface [polypeptide binding]; other site
541229013270	ribonuclease PH; Reviewed; Region: rph; PRK00173
541229013271	Ribonuclease PH; Region: RNase_PH_bact; cd11362
541229013272	hexamer interface [polypeptide binding]; other site
541229013273	active site
541229013274	Sporulation and spore germination; Region: Germane; pfam10646
541229013275	Spore germination protein [General function prediction only]; Region: COG5401
541229013276	Sporulation and spore germination; Region: Germane; pfam10646
541229013277	glutamate racemase; Provisional; Region: PRK00865
541229013278	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229013279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229013280	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
541229013281	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
541229013282	potential catalytic triad [active]
541229013283	conserved cys residue [active]
541229013284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229013285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229013286	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
541229013287	intracellular protease, PfpI family; Region: PfpI; TIGR01382
541229013288	potential catalytic triad [active]
541229013289	conserved cys residue [active]
541229013290	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229013291	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229013292	DNA binding residues [nucleotide binding]
541229013293	dimerization interface [polypeptide binding]; other site
541229013294	putative uracil/xanthine transporter; Provisional; Region: PRK11412
541229013295	putative deaminase; Validated; Region: PRK06846
541229013296	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
541229013297	active site
541229013298	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
541229013299	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229013300	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229013301	non-specific DNA binding site [nucleotide binding]; other site
541229013302	salt bridge; other site
541229013303	sequence-specific DNA binding site [nucleotide binding]; other site
541229013304	Cupin domain; Region: Cupin_2; pfam07883
541229013305	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
541229013306	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
541229013307	amphipathic channel; other site
541229013308	Asn-Pro-Ala signature motifs; other site
541229013309	Predicted transcriptional regulator [Transcription]; Region: COG1959
541229013310	Transcriptional regulator; Region: Rrf2; pfam02082
541229013311	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
541229013312	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
541229013313	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229013314	Walker A/P-loop; other site
541229013315	ATP binding site [chemical binding]; other site
541229013316	Q-loop/lid; other site
541229013317	ABC transporter signature motif; other site
541229013318	Walker B; other site
541229013319	D-loop; other site
541229013320	H-loop/switch region; other site
541229013321	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
541229013322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229013323	active site
541229013324	motif I; other site
541229013325	motif II; other site
541229013326	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
541229013327	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
541229013328	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
541229013329	ligand binding site [chemical binding]; other site
541229013330	flagellar motor protein MotA; Validated; Region: PRK08124
541229013331	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
541229013332	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
541229013333	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
541229013334	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
541229013335	active site
541229013336	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
541229013337	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
541229013338	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
541229013339	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
541229013340	L-aspartate oxidase; Provisional; Region: PRK06175
541229013341	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
541229013342	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
541229013343	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
541229013344	putative Iron-sulfur protein interface [polypeptide binding]; other site
541229013345	proximal heme binding site [chemical binding]; other site
541229013346	distal heme binding site [chemical binding]; other site
541229013347	putative dimer interface [polypeptide binding]; other site
541229013348	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
541229013349	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
541229013350	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
541229013351	GIY-YIG motif/motif A; other site
541229013352	active site
541229013353	catalytic site [active]
541229013354	putative DNA binding site [nucleotide binding]; other site
541229013355	metal binding site [ion binding]; metal-binding site
541229013356	UvrB/uvrC motif; Region: UVR; pfam02151
541229013357	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
541229013358	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229013359	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
541229013360	catalytic residues [active]
541229013361	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
541229013362	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
541229013363	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
541229013364	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
541229013365	Ligand binding site [chemical binding]; other site
541229013366	Electron transfer flavoprotein domain; Region: ETF; pfam01012
541229013367	enoyl-CoA hydratase; Provisional; Region: PRK07658
541229013368	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
541229013369	substrate binding site [chemical binding]; other site
541229013370	oxyanion hole (OAH) forming residues; other site
541229013371	trimer interface [polypeptide binding]; other site
541229013372	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
541229013373	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229013374	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229013375	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
541229013376	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
541229013377	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
541229013378	acyl-activating enzyme (AAE) consensus motif; other site
541229013379	putative AMP binding site [chemical binding]; other site
541229013380	putative active site [active]
541229013381	putative CoA binding site [chemical binding]; other site
541229013382	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
541229013383	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
541229013384	siderophore binding site; other site
541229013385	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229013386	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229013387	ABC-ATPase subunit  interface; other site
541229013388	dimer interface [polypeptide binding]; other site
541229013389	putative PBP binding regions; other site
541229013390	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229013391	ABC-ATPase subunit  interface; other site
541229013392	dimer interface [polypeptide binding]; other site
541229013393	putative PBP binding regions; other site
541229013394	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
541229013395	DinB family; Region: DinB; pfam05163
541229013396	DinB superfamily; Region: DinB_2; pfam12867
541229013397	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
541229013398	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
541229013399	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229013400	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
541229013401	Walker A/P-loop; other site
541229013402	ATP binding site [chemical binding]; other site
541229013403	Q-loop/lid; other site
541229013404	ABC transporter signature motif; other site
541229013405	Walker B; other site
541229013406	D-loop; other site
541229013407	H-loop/switch region; other site
541229013408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229013409	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229013410	dimer interface [polypeptide binding]; other site
541229013411	phosphorylation site [posttranslational modification]
541229013412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229013413	ATP binding site [chemical binding]; other site
541229013414	Mg2+ binding site [ion binding]; other site
541229013415	G-X-G motif; other site
541229013416	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229013417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229013418	active site
541229013419	phosphorylation site [posttranslational modification]
541229013420	intermolecular recognition site; other site
541229013421	dimerization interface [polypeptide binding]; other site
541229013422	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229013423	DNA binding site [nucleotide binding]
541229013424	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
541229013425	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
541229013426	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
541229013427	putative RNA binding site [nucleotide binding]; other site
541229013428	Methyltransferase domain; Region: Methyltransf_26; pfam13659
541229013429	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314
541229013430	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
541229013431	active site
541229013432	catalytic site [active]
541229013433	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
541229013434	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
541229013435	Walker A/P-loop; other site
541229013436	ATP binding site [chemical binding]; other site
541229013437	Q-loop/lid; other site
541229013438	ABC transporter signature motif; other site
541229013439	Walker B; other site
541229013440	D-loop; other site
541229013441	H-loop/switch region; other site
541229013442	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
541229013443	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229013444	ABC-ATPase subunit  interface; other site
541229013445	dimer interface [polypeptide binding]; other site
541229013446	putative PBP binding regions; other site
541229013447	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
541229013448	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
541229013449	intersubunit interface [polypeptide binding]; other site
541229013450	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013451	heme-binding site [chemical binding]; other site
541229013452	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013453	heme-binding site [chemical binding]; other site
541229013454	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013455	heme-binding site [chemical binding]; other site
541229013456	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013457	heme-binding site [chemical binding]; other site
541229013458	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013459	heme-binding site [chemical binding]; other site
541229013460	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013461	heme-binding site [chemical binding]; other site
541229013462	heme uptake protein IsdC; Region: IsdC; TIGR03656
541229013463	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
541229013464	heme-binding site [chemical binding]; other site
541229013465	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
541229013466	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
541229013467	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
541229013468	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229013469	RNA binding surface [nucleotide binding]; other site
541229013470	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
541229013471	probable active site [active]
541229013472	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
541229013473	MutS domain III; Region: MutS_III; pfam05192
541229013474	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
541229013475	Walker A/P-loop; other site
541229013476	ATP binding site [chemical binding]; other site
541229013477	Q-loop/lid; other site
541229013478	ABC transporter signature motif; other site
541229013479	Walker B; other site
541229013480	D-loop; other site
541229013481	H-loop/switch region; other site
541229013482	Smr domain; Region: Smr; pfam01713
541229013483	hypothetical protein; Provisional; Region: PRK08609
541229013484	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
541229013485	active site
541229013486	primer binding site [nucleotide binding]; other site
541229013487	NTP  binding site [chemical binding]; other site
541229013488	metal binding triad [ion binding]; metal-binding site
541229013489	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
541229013490	active site
541229013491	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
541229013492	Colicin V production protein; Region: Colicin_V; pfam02674
541229013493	cell division protein ZapA; Provisional; Region: PRK14126
541229013494	ribonuclease HIII; Provisional; Region: PRK00996
541229013495	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
541229013496	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
541229013497	RNA/DNA hybrid binding site [nucleotide binding]; other site
541229013498	active site
541229013499	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
541229013500	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
541229013501	putative dimer interface [polypeptide binding]; other site
541229013502	putative anticodon binding site; other site
541229013503	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
541229013504	homodimer interface [polypeptide binding]; other site
541229013505	motif 1; other site
541229013506	motif 2; other site
541229013507	active site
541229013508	motif 3; other site
541229013509	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
541229013510	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
541229013511	putative tRNA-binding site [nucleotide binding]; other site
541229013512	B3/4 domain; Region: B3_4; pfam03483
541229013513	tRNA synthetase B5 domain; Region: B5; smart00874
541229013514	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
541229013515	dimer interface [polypeptide binding]; other site
541229013516	motif 1; other site
541229013517	motif 3; other site
541229013518	motif 2; other site
541229013519	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
541229013520	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
541229013521	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
541229013522	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
541229013523	dimer interface [polypeptide binding]; other site
541229013524	motif 1; other site
541229013525	active site
541229013526	motif 2; other site
541229013527	motif 3; other site
541229013528	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
541229013529	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
541229013530	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
541229013531	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
541229013532	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229013533	Zn2+ binding site [ion binding]; other site
541229013534	Mg2+ binding site [ion binding]; other site
541229013535	CAAX protease self-immunity; Region: Abi; pfam02517
541229013536	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
541229013537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229013538	putative substrate translocation pore; other site
541229013539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229013540	HlyD family secretion protein; Region: HlyD_3; pfam13437
541229013541	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229013542	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229013543	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
541229013544	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
541229013545	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
541229013546	oligomer interface [polypeptide binding]; other site
541229013547	active site
541229013548	metal binding site [ion binding]; metal-binding site
541229013549	dUTPase; Region: dUTPase_2; pfam08761
541229013550	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
541229013551	active site
541229013552	homodimer interface [polypeptide binding]; other site
541229013553	metal binding site [ion binding]; metal-binding site
541229013554	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
541229013555	23S rRNA binding site [nucleotide binding]; other site
541229013556	L21 binding site [polypeptide binding]; other site
541229013557	L13 binding site [polypeptide binding]; other site
541229013558	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
541229013559	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
541229013560	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
541229013561	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
541229013562	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
541229013563	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
541229013564	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
541229013565	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
541229013566	active site
541229013567	dimer interface [polypeptide binding]; other site
541229013568	motif 1; other site
541229013569	motif 2; other site
541229013570	motif 3; other site
541229013571	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
541229013572	anticodon binding site; other site
541229013573	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
541229013574	primosomal protein DnaI; Reviewed; Region: PRK08939
541229013575	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
541229013576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229013577	Walker A motif; other site
541229013578	ATP binding site [chemical binding]; other site
541229013579	Walker B motif; other site
541229013580	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
541229013581	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
541229013582	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
541229013583	ATP cone domain; Region: ATP-cone; pfam03477
541229013584	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
541229013585	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
541229013586	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
541229013587	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
541229013588	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
541229013589	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
541229013590	CoA-binding site [chemical binding]; other site
541229013591	ATP-binding [chemical binding]; other site
541229013592	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
541229013593	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
541229013594	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
541229013595	DNA binding site [nucleotide binding]
541229013596	catalytic residue [active]
541229013597	H2TH interface [polypeptide binding]; other site
541229013598	putative catalytic residues [active]
541229013599	turnover-facilitating residue; other site
541229013600	intercalation triad [nucleotide binding]; other site
541229013601	8OG recognition residue [nucleotide binding]; other site
541229013602	putative reading head residues; other site
541229013603	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
541229013604	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
541229013605	DNA polymerase I; Provisional; Region: PRK05755
541229013606	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
541229013607	active site
541229013608	metal binding site 1 [ion binding]; metal-binding site
541229013609	putative 5' ssDNA interaction site; other site
541229013610	metal binding site 3; metal-binding site
541229013611	metal binding site 2 [ion binding]; metal-binding site
541229013612	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
541229013613	putative DNA binding site [nucleotide binding]; other site
541229013614	putative metal binding site [ion binding]; other site
541229013615	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
541229013616	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
541229013617	active site
541229013618	DNA binding site [nucleotide binding]
541229013619	catalytic site [active]
541229013620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229013621	dimerization interface [polypeptide binding]; other site
541229013622	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
541229013623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229013624	putative active site [active]
541229013625	heme pocket [chemical binding]; other site
541229013626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229013627	dimer interface [polypeptide binding]; other site
541229013628	phosphorylation site [posttranslational modification]
541229013629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229013630	ATP binding site [chemical binding]; other site
541229013631	Mg2+ binding site [ion binding]; other site
541229013632	G-X-G motif; other site
541229013633	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229013634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229013635	active site
541229013636	phosphorylation site [posttranslational modification]
541229013637	intermolecular recognition site; other site
541229013638	dimerization interface [polypeptide binding]; other site
541229013639	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229013640	DNA binding site [nucleotide binding]
541229013641	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
541229013642	active site 2 [active]
541229013643	active site 1 [active]
541229013644	malate dehydrogenase; Reviewed; Region: PRK06223
541229013645	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
541229013646	NAD(P) binding site [chemical binding]; other site
541229013647	dimer interface [polypeptide binding]; other site
541229013648	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229013649	substrate binding site [chemical binding]; other site
541229013650	isocitrate dehydrogenase; Reviewed; Region: PRK07006
541229013651	isocitrate dehydrogenase; Validated; Region: PRK07362
541229013652	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
541229013653	dimer interface [polypeptide binding]; other site
541229013654	Citrate synthase; Region: Citrate_synt; pfam00285
541229013655	active site
541229013656	citrylCoA binding site [chemical binding]; other site
541229013657	oxalacetate/citrate binding site [chemical binding]; other site
541229013658	coenzyme A binding site [chemical binding]; other site
541229013659	catalytic triad [active]
541229013660	Protein of unknown function (DUF441); Region: DUF441; pfam04284
541229013661	sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872
541229013662	Domain of unknown function DUF20; Region: UPF0118; pfam01594
541229013663	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
541229013664	pyruvate kinase; Provisional; Region: PRK06354
541229013665	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
541229013666	domain interfaces; other site
541229013667	active site
541229013668	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
541229013669	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
541229013670	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
541229013671	active site
541229013672	ADP/pyrophosphate binding site [chemical binding]; other site
541229013673	dimerization interface [polypeptide binding]; other site
541229013674	allosteric effector site; other site
541229013675	fructose-1,6-bisphosphate binding site; other site
541229013676	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
541229013677	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
541229013678	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
541229013679	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
541229013680	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
541229013681	Transcriptional regulators [Transcription]; Region: FadR; COG2186
541229013682	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229013683	DNA-binding site [nucleotide binding]; DNA binding site
541229013684	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
541229013685	Malic enzyme, N-terminal domain; Region: malic; pfam00390
541229013686	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
541229013687	putative NAD(P) binding site [chemical binding]; other site
541229013688	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
541229013689	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
541229013690	active site
541229013691	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
541229013692	generic binding surface II; other site
541229013693	generic binding surface I; other site
541229013694	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
541229013695	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
541229013696	DHH family; Region: DHH; pfam01368
541229013697	DHHA1 domain; Region: DHHA1; pfam02272
541229013698	YtpI-like protein; Region: YtpI; pfam14007
541229013699	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
541229013700	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
541229013701	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229013702	DNA-binding site [nucleotide binding]; DNA binding site
541229013703	DRTGG domain; Region: DRTGG; pfam07085
541229013704	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
541229013705	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
541229013706	active site 2 [active]
541229013707	active site 1 [active]
541229013708	metal-dependent hydrolase; Provisional; Region: PRK00685
541229013709	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
541229013710	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
541229013711	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
541229013712	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
541229013713	active site
541229013714	Protein of unknown function (DUF3221); Region: DUF3221; pfam11518
541229013715	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
541229013716	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
541229013717	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229013718	Coenzyme A binding pocket [chemical binding]; other site
541229013719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229013720	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229013721	Coenzyme A binding pocket [chemical binding]; other site
541229013722	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
541229013723	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
541229013724	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
541229013725	hexamer interface [polypeptide binding]; other site
541229013726	ligand binding site [chemical binding]; other site
541229013727	putative active site [active]
541229013728	NAD(P) binding site [chemical binding]; other site
541229013729	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
541229013730	classical (c) SDRs; Region: SDR_c; cd05233
541229013731	NAD(P) binding site [chemical binding]; other site
541229013732	active site
541229013733	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
541229013734	Ligand Binding Site [chemical binding]; other site
541229013735	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
541229013736	argininosuccinate lyase; Provisional; Region: PRK00855
541229013737	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
541229013738	active sites [active]
541229013739	tetramer interface [polypeptide binding]; other site
541229013740	argininosuccinate synthase; Provisional; Region: PRK13820
541229013741	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
541229013742	ANP binding site [chemical binding]; other site
541229013743	Substrate Binding Site II [chemical binding]; other site
541229013744	Substrate Binding Site I [chemical binding]; other site
541229013745	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229013746	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229013747	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229013748	EcsC protein family; Region: EcsC; pfam12787
541229013749	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
541229013750	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
541229013751	nudix motif; other site
541229013752	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
541229013753	propionate/acetate kinase; Provisional; Region: PRK12379
541229013754	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
541229013755	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229013756	S-adenosylmethionine binding site [chemical binding]; other site
541229013757	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
541229013758	dimer interface [polypeptide binding]; other site
541229013759	catalytic triad [active]
541229013760	peroxidatic and resolving cysteines [active]
541229013761	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
541229013762	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
541229013763	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
541229013764	ATP-NAD kinase; Region: NAD_kinase; pfam01513
541229013765	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
541229013766	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
541229013767	active site
541229013768	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229013769	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
541229013770	dimer interface [polypeptide binding]; other site
541229013771	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
541229013772	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
541229013773	active site
541229013774	acyl-activating enzyme (AAE) consensus motif; other site
541229013775	putative CoA binding site [chemical binding]; other site
541229013776	AMP binding site [chemical binding]; other site
541229013777	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
541229013778	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
541229013779	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
541229013780	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
541229013781	Ligand Binding Site [chemical binding]; other site
541229013782	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
541229013783	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
541229013784	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229013785	catalytic residue [active]
541229013786	septation ring formation regulator EzrA; Provisional; Region: PRK04778
541229013787	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229013788	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229013789	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
541229013790	dimerization interface [polypeptide binding]; other site
541229013791	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229013792	EamA-like transporter family; Region: EamA; pfam00892
541229013793	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229013794	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229013795	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
541229013796	GAF domain; Region: GAF_2; pfam13185
541229013797	methionine gamma-lyase; Provisional; Region: PRK06767
541229013798	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
541229013799	homodimer interface [polypeptide binding]; other site
541229013800	substrate-cofactor binding pocket; other site
541229013801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229013802	catalytic residue [active]
541229013803	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
541229013804	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
541229013805	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229013806	RNA binding surface [nucleotide binding]; other site
541229013807	Uncharacterized conserved protein [Function unknown]; Region: COG4748
541229013808	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
541229013809	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
541229013810	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
541229013811	active site
541229013812	HIGH motif; other site
541229013813	dimer interface [polypeptide binding]; other site
541229013814	KMSKS motif; other site
541229013815	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229013816	RNA binding surface [nucleotide binding]; other site
541229013817	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
541229013818	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229013819	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229013820	DNA binding residues [nucleotide binding]
541229013821	maltose O-acetyltransferase; Provisional; Region: PRK10092
541229013822	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
541229013823	active site
541229013824	substrate binding site [chemical binding]; other site
541229013825	trimer interface [polypeptide binding]; other site
541229013826	CoA binding site [chemical binding]; other site
541229013827	acetyl-CoA synthetase; Provisional; Region: PRK04319
541229013828	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
541229013829	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
541229013830	active site
541229013831	acyl-activating enzyme (AAE) consensus motif; other site
541229013832	putative CoA binding site [chemical binding]; other site
541229013833	AMP binding site [chemical binding]; other site
541229013834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229013835	Coenzyme A binding pocket [chemical binding]; other site
541229013836	FOG: CBS domain [General function prediction only]; Region: COG0517
541229013837	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
541229013838	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
541229013839	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
541229013840	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
541229013841	active site
541229013842	Zn binding site [ion binding]; other site
541229013843	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
541229013844	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229013845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229013846	active site
541229013847	phosphorylation site [posttranslational modification]
541229013848	intermolecular recognition site; other site
541229013849	dimerization interface [polypeptide binding]; other site
541229013850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229013851	DNA binding site [nucleotide binding]
541229013852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229013853	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229013854	dimerization interface [polypeptide binding]; other site
541229013855	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229013856	dimer interface [polypeptide binding]; other site
541229013857	phosphorylation site [posttranslational modification]
541229013858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229013859	ATP binding site [chemical binding]; other site
541229013860	Mg2+ binding site [ion binding]; other site
541229013861	G-X-G motif; other site
541229013862	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
541229013863	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
541229013864	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
541229013865	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
541229013866	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
541229013867	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
541229013868	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
541229013869	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955
541229013870	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
541229013871	Protein of unknown function (DUF3917); Region: DUF3917; pfam13055
541229013872	Protein of unknown function (DUF3949); Region: DUF3949; pfam13133
541229013873	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
541229013874	catabolite control protein A; Region: ccpA; TIGR01481
541229013875	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229013876	DNA binding site [nucleotide binding]
541229013877	domain linker motif; other site
541229013878	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
541229013879	dimerization interface [polypeptide binding]; other site
541229013880	effector binding site; other site
541229013881	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
541229013882	putative dimer interface [polypeptide binding]; other site
541229013883	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
541229013884	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
541229013885	putative dimer interface [polypeptide binding]; other site
541229013886	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
541229013887	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
541229013888	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
541229013889	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
541229013890	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
541229013891	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
541229013892	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229013893	Coenzyme A binding pocket [chemical binding]; other site
541229013894	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229013895	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229013896	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229013897	EamA-like transporter family; Region: EamA; pfam00892
541229013898	EamA-like transporter family; Region: EamA; pfam00892
541229013899	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
541229013900	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229013901	DNA binding residues [nucleotide binding]
541229013902	putative dimer interface [polypeptide binding]; other site
541229013903	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
541229013904	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
541229013905	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
541229013906	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
541229013907	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
541229013908	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
541229013909	active site
541229013910	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
541229013911	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229013912	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
541229013913	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
541229013914	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
541229013915	active site
541229013916	metal binding site [ion binding]; metal-binding site
541229013917	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
541229013918	putative tRNA-binding site [nucleotide binding]; other site
541229013919	hypothetical protein; Provisional; Region: PRK13668
541229013920	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229013921	catalytic residues [active]
541229013922	NTPase; Reviewed; Region: PRK03114
541229013923	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
541229013924	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
541229013925	oligomer interface [polypeptide binding]; other site
541229013926	active site
541229013927	metal binding site [ion binding]; metal-binding site
541229013928	Predicted small secreted protein [Function unknown]; Region: COG5584
541229013929	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229013930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229013931	S-adenosylmethionine binding site [chemical binding]; other site
541229013932	Phosphotransferase enzyme family; Region: APH; pfam01636
541229013933	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
541229013934	active site
541229013935	substrate binding site [chemical binding]; other site
541229013936	ATP binding site [chemical binding]; other site
541229013937	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
541229013938	pullulanase, type I; Region: pulA_typeI; TIGR02104
541229013939	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
541229013940	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
541229013941	Ca binding site [ion binding]; other site
541229013942	active site
541229013943	catalytic site [active]
541229013944	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
541229013945	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
541229013946	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
541229013947	dipeptidase PepV; Reviewed; Region: PRK07318
541229013948	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
541229013949	active site
541229013950	metal binding site [ion binding]; metal-binding site
541229013951	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
541229013952	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
541229013953	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229013954	RNA binding surface [nucleotide binding]; other site
541229013955	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
541229013956	active site
541229013957	uracil binding [chemical binding]; other site
541229013958	stage V sporulation protein B; Region: spore_V_B; TIGR02900
541229013959	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
541229013960	HI0933-like protein; Region: HI0933_like; pfam03486
541229013961	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229013962	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
541229013963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229013964	putative substrate translocation pore; other site
541229013965	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229013966	dimerization interface [polypeptide binding]; other site
541229013967	putative DNA binding site [nucleotide binding]; other site
541229013968	putative Zn2+ binding site [ion binding]; other site
541229013969	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
541229013970	putative hydrophobic ligand binding site [chemical binding]; other site
541229013971	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
541229013972	Protein of unknown function (DUF2758); Region: DUF2758; pfam10957
541229013973	Protein of unknown function (DUF2553); Region: DUF2553; pfam10830
541229013974	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
541229013975	glucose-1-dehydrogenase; Provisional; Region: PRK08936
541229013976	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
541229013977	NAD binding site [chemical binding]; other site
541229013978	homodimer interface [polypeptide binding]; other site
541229013979	active site
541229013980	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
541229013981	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
541229013982	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
541229013983	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
541229013984	MoaE interaction surface [polypeptide binding]; other site
541229013985	MoeB interaction surface [polypeptide binding]; other site
541229013986	thiocarboxylated glycine; other site
541229013987	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
541229013988	MoaE homodimer interface [polypeptide binding]; other site
541229013989	MoaD interaction [polypeptide binding]; other site
541229013990	active site residues [active]
541229013991	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
541229013992	Walker A motif; other site
541229013993	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
541229013994	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
541229013995	dimer interface [polypeptide binding]; other site
541229013996	putative functional site; other site
541229013997	putative MPT binding site; other site
541229013998	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
541229013999	trimer interface [polypeptide binding]; other site
541229014000	dimer interface [polypeptide binding]; other site
541229014001	putative active site [active]
541229014002	thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475
541229014003	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
541229014004	ATP binding site [chemical binding]; other site
541229014005	substrate interface [chemical binding]; other site
541229014006	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
541229014007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229014008	FeS/SAM binding site; other site
541229014009	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
541229014010	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
541229014011	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
541229014012	active site residue [active]
541229014013	homoserine O-acetyltransferase; Provisional; Region: PRK06765
541229014014	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
541229014015	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
541229014016	Spore germination protein; Region: Spore_permease; pfam03845
541229014017	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
541229014018	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
541229014019	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
541229014020	putative nucleotide binding site [chemical binding]; other site
541229014021	putative metal binding site [ion binding]; other site
541229014022	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
541229014023	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
541229014024	HIGH motif; other site
541229014025	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
541229014026	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
541229014027	active site
541229014028	KMSKS motif; other site
541229014029	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
541229014030	tRNA binding surface [nucleotide binding]; other site
541229014031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229014032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229014033	putative substrate translocation pore; other site
541229014034	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
541229014035	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
541229014036	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
541229014037	TrkA-C domain; Region: TrkA_C; pfam02080
541229014038	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
541229014039	Int/Topo IB signature motif; other site
541229014040	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229014041	FtsX-like permease family; Region: FtsX; pfam02687
541229014042	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229014043	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229014044	Walker A/P-loop; other site
541229014045	ATP binding site [chemical binding]; other site
541229014046	Q-loop/lid; other site
541229014047	ABC transporter signature motif; other site
541229014048	Walker B; other site
541229014049	D-loop; other site
541229014050	H-loop/switch region; other site
541229014051	Predicted membrane protein [Function unknown]; Region: COG2311
541229014052	Protein of unknown function (DUF418); Region: DUF418; cl12135
541229014053	Protein of unknown function (DUF418); Region: DUF418; pfam04235
541229014054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229014055	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229014056	Probable transposase; Region: OrfB_IS605; pfam01385
541229014057	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229014058	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
541229014059	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
541229014060	catalytic residues [active]
541229014061	Protein of unknown function (DUF2524); Region: DUF2524; pfam10732
541229014062	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
541229014063	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229014064	FeS/SAM binding site; other site
541229014065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229014066	S-adenosylmethionine binding site [chemical binding]; other site
541229014067	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
541229014068	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229014069	Walker A/P-loop; other site
541229014070	ATP binding site [chemical binding]; other site
541229014071	Q-loop/lid; other site
541229014072	ABC transporter signature motif; other site
541229014073	Walker B; other site
541229014074	D-loop; other site
541229014075	H-loop/switch region; other site
541229014076	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
541229014077	aspartate racemase; Region: asp_race; TIGR00035
541229014078	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
541229014079	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
541229014080	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
541229014081	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
541229014082	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229014083	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229014084	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
541229014085	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
541229014086	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
541229014087	trimer interface [polypeptide binding]; other site
541229014088	putative metal binding site [ion binding]; other site
541229014089	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
541229014090	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
541229014091	active site
541229014092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229014093	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
541229014094	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
541229014095	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
541229014096	GTP binding site; other site
541229014097	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
541229014098	MPT binding site; other site
541229014099	trimer interface [polypeptide binding]; other site
541229014100	S-adenosylmethionine synthetase; Validated; Region: PRK05250
541229014101	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
541229014102	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
541229014103	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
541229014104	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
541229014105	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
541229014106	active site
541229014107	substrate-binding site [chemical binding]; other site
541229014108	metal-binding site [ion binding]
541229014109	ATP binding site [chemical binding]; other site
541229014110	ATP synthase I chain; Region: ATP_synt_I; pfam03899
541229014111	EamA-like transporter family; Region: EamA; pfam00892
541229014112	EamA-like transporter family; Region: EamA; pfam00892
541229014113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
541229014114	Uncharacterized conserved protein [Function unknown]; Region: COG0327
541229014115	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
541229014116	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
541229014117	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
541229014118	WxL domain surface cell wall-binding; Region: WxL; pfam13731
541229014119	WxL domain surface cell wall-binding; Region: WxL; pfam13731
541229014120	WxL domain surface cell wall-binding; Region: WxL; pfam13731
541229014121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229014122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229014123	ATP binding site [chemical binding]; other site
541229014124	Mg2+ binding site [ion binding]; other site
541229014125	G-X-G motif; other site
541229014126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229014127	dimer interface [polypeptide binding]; other site
541229014128	phosphorylation site [posttranslational modification]
541229014129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229014130	ATP binding site [chemical binding]; other site
541229014131	Mg2+ binding site [ion binding]; other site
541229014132	G-X-G motif; other site
541229014133	hydroperoxidase II; Provisional; Region: katE; PRK11249
541229014134	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
541229014135	heme binding pocket [chemical binding]; other site
541229014136	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
541229014137	domain interactions; other site
541229014138	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
541229014139	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
541229014140	TAP-like protein; Region: Abhydrolase_4; pfam08386
541229014141	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
541229014142	TM-ABC transporter signature motif; other site
541229014143	Sulfatase; Region: Sulfatase; pfam00884
541229014144	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
541229014145	Protein of unknown function (DUF3986); Region: DUF3986; pfam13143
541229014146	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
541229014147	NMT1-like family; Region: NMT1_2; pfam13379
541229014148	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
541229014149	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
541229014150	Walker A/P-loop; other site
541229014151	ATP binding site [chemical binding]; other site
541229014152	Q-loop/lid; other site
541229014153	ABC transporter signature motif; other site
541229014154	Walker B; other site
541229014155	D-loop; other site
541229014156	H-loop/switch region; other site
541229014157	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
541229014158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229014159	dimer interface [polypeptide binding]; other site
541229014160	conserved gate region; other site
541229014161	putative PBP binding loops; other site
541229014162	ABC-ATPase subunit interface; other site
541229014163	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
541229014164	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229014165	motif II; other site
541229014166	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
541229014167	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
541229014168	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
541229014169	nudix motif; other site
541229014170	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
541229014171	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229014172	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
541229014173	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
541229014174	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229014175	DNA binding residues [nucleotide binding]
541229014176	dimer interface [polypeptide binding]; other site
541229014177	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
541229014178	S-ribosylhomocysteinase; Provisional; Region: PRK02260
541229014179	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
541229014180	active site clefts [active]
541229014181	zinc binding site [ion binding]; other site
541229014182	dimer interface [polypeptide binding]; other site
541229014183	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
541229014184	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
541229014185	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
541229014186	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
541229014187	Uncharacterized conserved protein [Function unknown]; Region: COG1434
541229014188	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
541229014189	putative active site [active]
541229014190	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229014191	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229014192	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229014193	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229014194	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
541229014195	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
541229014196	Predicted membrane protein [Function unknown]; Region: COG3766
541229014197	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
541229014198	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
541229014199	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
541229014200	G1 box; other site
541229014201	GTP/Mg2+ binding site [chemical binding]; other site
541229014202	Switch I region; other site
541229014203	G2 box; other site
541229014204	G3 box; other site
541229014205	Switch II region; other site
541229014206	G4 box; other site
541229014207	G5 box; other site
541229014208	Nucleoside recognition; Region: Gate; pfam07670
541229014209	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
541229014210	Nucleoside recognition; Region: Gate; pfam07670
541229014211	FeoA domain; Region: FeoA; pfam04023
541229014212	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
541229014213	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229014214	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229014215	dimerization interface [polypeptide binding]; other site
541229014216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229014217	dimer interface [polypeptide binding]; other site
541229014218	phosphorylation site [posttranslational modification]
541229014219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229014220	ATP binding site [chemical binding]; other site
541229014221	Mg2+ binding site [ion binding]; other site
541229014222	G-X-G motif; other site
541229014223	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229014224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229014225	active site
541229014226	phosphorylation site [posttranslational modification]
541229014227	intermolecular recognition site; other site
541229014228	dimerization interface [polypeptide binding]; other site
541229014229	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229014230	DNA binding site [nucleotide binding]
541229014231	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
541229014232	active site
541229014233	catalytic site [active]
541229014234	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229014235	active site
541229014236	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
541229014237	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
541229014238	Cold-inducible protein YdjO; Region: YdjO; pfam14169
541229014239	FtsX-like permease family; Region: FtsX; pfam02687
541229014240	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229014241	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229014242	Walker A/P-loop; other site
541229014243	ATP binding site [chemical binding]; other site
541229014244	Q-loop/lid; other site
541229014245	ABC transporter signature motif; other site
541229014246	Walker B; other site
541229014247	D-loop; other site
541229014248	H-loop/switch region; other site
541229014249	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
541229014250	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229014251	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229014252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229014253	S-adenosylmethionine binding site [chemical binding]; other site
541229014254	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229014255	FtsX-like permease family; Region: FtsX; pfam02687
541229014256	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229014257	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229014258	Walker A/P-loop; other site
541229014259	ATP binding site [chemical binding]; other site
541229014260	Q-loop/lid; other site
541229014261	ABC transporter signature motif; other site
541229014262	Walker B; other site
541229014263	D-loop; other site
541229014264	H-loop/switch region; other site
541229014265	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
541229014266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
541229014267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
541229014268	SdpI/YhfL protein family; Region: SdpI; pfam13630
541229014269	Predicted integral membrane protein [Function unknown]; Region: COG5658
541229014270	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
541229014271	SdpI/YhfL protein family; Region: SdpI; pfam13630
541229014272	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229014273	dimerization interface [polypeptide binding]; other site
541229014274	putative DNA binding site [nucleotide binding]; other site
541229014275	putative Zn2+ binding site [ion binding]; other site
541229014276	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229014277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229014278	active site
541229014279	phosphorylation site [posttranslational modification]
541229014280	intermolecular recognition site; other site
541229014281	dimerization interface [polypeptide binding]; other site
541229014282	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229014283	DNA binding site [nucleotide binding]
541229014284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229014285	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
541229014286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229014287	ATP binding site [chemical binding]; other site
541229014288	Mg2+ binding site [ion binding]; other site
541229014289	G-X-G motif; other site
541229014290	FtsX-like permease family; Region: FtsX; pfam02687
541229014291	FtsX-like permease family; Region: FtsX; pfam02687
541229014292	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229014293	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229014294	Walker A/P-loop; other site
541229014295	ATP binding site [chemical binding]; other site
541229014296	Q-loop/lid; other site
541229014297	ABC transporter signature motif; other site
541229014298	Walker B; other site
541229014299	D-loop; other site
541229014300	H-loop/switch region; other site
541229014301	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229014302	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229014303	GntP family permease; Region: GntP_permease; pfam02447
541229014304	fructuronate transporter; Provisional; Region: PRK10034; cl15264
541229014305	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
541229014306	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
541229014307	DNA-binding site [nucleotide binding]; DNA binding site
541229014308	UTRA domain; Region: UTRA; pfam07702
541229014309	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
541229014310	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
541229014311	substrate binding site [chemical binding]; other site
541229014312	ATP binding site [chemical binding]; other site
541229014313	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
541229014314	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
541229014315	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229014316	catalytic residue [active]
541229014317	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
541229014318	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
541229014319	active site
541229014320	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
541229014321	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
541229014322	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
541229014323	dimerization interface [polypeptide binding]; other site
541229014324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229014325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229014326	dimer interface [polypeptide binding]; other site
541229014327	phosphorylation site [posttranslational modification]
541229014328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229014329	ATP binding site [chemical binding]; other site
541229014330	Mg2+ binding site [ion binding]; other site
541229014331	G-X-G motif; other site
541229014332	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229014333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229014334	active site
541229014335	phosphorylation site [posttranslational modification]
541229014336	intermolecular recognition site; other site
541229014337	dimerization interface [polypeptide binding]; other site
541229014338	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229014339	DNA binding site [nucleotide binding]
541229014340	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
541229014341	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
541229014342	active site
541229014343	octamer interface [polypeptide binding]; other site
541229014344	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
541229014345	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
541229014346	acyl-activating enzyme (AAE) consensus motif; other site
541229014347	putative AMP binding site [chemical binding]; other site
541229014348	putative active site [active]
541229014349	putative CoA binding site [chemical binding]; other site
541229014350	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
541229014351	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
541229014352	substrate binding site [chemical binding]; other site
541229014353	oxyanion hole (OAH) forming residues; other site
541229014354	trimer interface [polypeptide binding]; other site
541229014355	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
541229014356	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
541229014357	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
541229014358	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
541229014359	dimer interface [polypeptide binding]; other site
541229014360	tetramer interface [polypeptide binding]; other site
541229014361	PYR/PP interface [polypeptide binding]; other site
541229014362	TPP binding site [chemical binding]; other site
541229014363	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
541229014364	TPP-binding site; other site
541229014365	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
541229014366	chorismate binding enzyme; Region: Chorismate_bind; cl10555
541229014367	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
541229014368	UbiA prenyltransferase family; Region: UbiA; pfam01040
541229014369	regulatory protein, yteA family; Region: bacill_yteA; TIGR02890
541229014370	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
541229014371	DNA-binding site [nucleotide binding]; DNA binding site
541229014372	RNA-binding motif; other site
541229014373	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
541229014374	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
541229014375	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229014376	DNA binding residues [nucleotide binding]
541229014377	dimer interface [polypeptide binding]; other site
541229014378	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
541229014379	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
541229014380	active site flap/lid [active]
541229014381	nucleophilic elbow; other site
541229014382	catalytic triad [active]
541229014383	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
541229014384	homodimer interface [polypeptide binding]; other site
541229014385	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
541229014386	active site pocket [active]
541229014387	glycogen synthase; Provisional; Region: glgA; PRK00654
541229014388	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
541229014389	ADP-binding pocket [chemical binding]; other site
541229014390	homodimer interface [polypeptide binding]; other site
541229014391	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
541229014392	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
541229014393	ligand binding site; other site
541229014394	oligomer interface; other site
541229014395	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
541229014396	dimer interface [polypeptide binding]; other site
541229014397	N-terminal domain interface [polypeptide binding]; other site
541229014398	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
541229014399	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
541229014400	ligand binding site; other site
541229014401	oligomer interface; other site
541229014402	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
541229014403	dimer interface [polypeptide binding]; other site
541229014404	N-terminal domain interface [polypeptide binding]; other site
541229014405	sulfate 1 binding site; other site
541229014406	glycogen branching enzyme; Provisional; Region: PRK12313
541229014407	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
541229014408	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
541229014409	active site
541229014410	catalytic site [active]
541229014411	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
541229014412	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
541229014413	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
541229014414	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
541229014415	putative active site [active]
541229014416	catalytic triad [active]
541229014417	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
541229014418	PA/protease domain interface [polypeptide binding]; other site
541229014419	putative integrin binding motif; other site
541229014420	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
541229014421	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
541229014422	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
541229014423	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
541229014424	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229014425	NAD binding site [chemical binding]; other site
541229014426	dimer interface [polypeptide binding]; other site
541229014427	substrate binding site [chemical binding]; other site
541229014428	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
541229014429	MgtC family; Region: MgtC; pfam02308
541229014430	Ion channel; Region: Ion_trans_2; pfam07885
541229014431	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
541229014432	TrkA-N domain; Region: TrkA_N; pfam02254
541229014433	YugN-like family; Region: YugN; pfam08868
541229014434	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
541229014435	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
541229014436	active site
541229014437	dimer interface [polypeptide binding]; other site
541229014438	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
541229014439	dimer interface [polypeptide binding]; other site
541229014440	active site
541229014441	Domain of unknown function (DUF378); Region: DUF378; pfam04070
541229014442	general stress protein 13; Validated; Region: PRK08059
541229014443	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
541229014444	RNA binding site [nucleotide binding]; other site
541229014445	hypothetical protein; Validated; Region: PRK07682
541229014446	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229014447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229014448	homodimer interface [polypeptide binding]; other site
541229014449	catalytic residue [active]
541229014450	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
541229014451	AsnC family; Region: AsnC_trans_reg; pfam01037
541229014452	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
541229014453	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
541229014454	dimerization interface [polypeptide binding]; other site
541229014455	ligand binding site [chemical binding]; other site
541229014456	NADP binding site [chemical binding]; other site
541229014457	catalytic site [active]
541229014458	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
541229014459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
541229014460	nucleophilic elbow; other site
541229014461	catalytic triad; other site
541229014462	Domain of unknown function (DUF1871); Region: DUF1871; pfam08958
541229014463	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
541229014464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
541229014465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229014466	homodimer interface [polypeptide binding]; other site
541229014467	catalytic residue [active]
541229014468	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
541229014469	E-class dimer interface [polypeptide binding]; other site
541229014470	P-class dimer interface [polypeptide binding]; other site
541229014471	active site
541229014472	Cu2+ binding site [ion binding]; other site
541229014473	Zn2+ binding site [ion binding]; other site
541229014474	Kinase associated protein B; Region: KapB; pfam08810
541229014475	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
541229014476	active site
541229014477	catalytic site [active]
541229014478	substrate binding site [chemical binding]; other site
541229014479	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
541229014480	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
541229014481	transmembrane helices; other site
541229014482	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
541229014483	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
541229014484	active site
541229014485	glycyl-tRNA synthetase; Provisional; Region: PRK04173
541229014486	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
541229014487	motif 1; other site
541229014488	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
541229014489	active site
541229014490	motif 2; other site
541229014491	motif 3; other site
541229014492	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
541229014493	anticodon binding site; other site
541229014494	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
541229014495	CoenzymeA binding site [chemical binding]; other site
541229014496	subunit interaction site [polypeptide binding]; other site
541229014497	PHB binding site; other site
541229014498	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
541229014499	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
541229014500	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
541229014501	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
541229014502	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
541229014503	active site
541229014504	tetramer interface; other site
541229014505	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
541229014506	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
541229014507	active site
541229014508	substrate binding site [chemical binding]; other site
541229014509	metal binding site [ion binding]; metal-binding site
541229014510	Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372
541229014511	Uncharacterized conserved protein [Function unknown]; Region: COG1624
541229014512	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
541229014513	Divergent PAP2 family; Region: DUF212; cl00855
541229014514	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
541229014515	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
541229014516	multifunctional aminopeptidase A; Provisional; Region: PRK00913
541229014517	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
541229014518	interface (dimer of trimers) [polypeptide binding]; other site
541229014519	Substrate-binding/catalytic site; other site
541229014520	Zn-binding sites [ion binding]; other site
541229014521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
541229014522	Putative membrane protein; Region: YuiB; pfam14068
541229014523	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
541229014524	nudix motif; other site
541229014525	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
541229014526	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229014527	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
541229014528	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229014529	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229014530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
541229014531	H+ Antiporter protein; Region: 2A0121; TIGR00900
541229014532	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229014533	putative substrate translocation pore; other site
541229014534	Helix-turn-helix domain; Region: HTH_36; pfam13730
541229014535	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
541229014536	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
541229014537	putative DNA binding site [nucleotide binding]; other site
541229014538	dimerization interface [polypeptide binding]; other site
541229014539	Protein of unknown function (DUF523); Region: DUF523; pfam04463
541229014540	Helix-turn-helix domain; Region: HTH_36; pfam13730
541229014541	Replication-relaxation; Region: Replic_Relax; pfam13814
541229014542	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
541229014543	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229014544	non-specific DNA binding site [nucleotide binding]; other site
541229014545	salt bridge; other site
541229014546	sequence-specific DNA binding site [nucleotide binding]; other site
541229014547	hypothetical protein; Region: PHA02436
541229014548	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
541229014549	amidase catalytic site [active]
541229014550	Zn binding residues [ion binding]; other site
541229014551	substrate binding site [chemical binding]; other site
541229014552	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229014553	Holin family; Region: Phage_holin_4; pfam05105
541229014554	Haemolysin XhlA; Region: XhlA; pfam10779
541229014555	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
541229014556	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
541229014557	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
541229014558	Phage tail protein; Region: Sipho_tail; cl17486
541229014559	Phage-related minor tail protein [Function unknown]; Region: COG5280
541229014560	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
541229014561	membrane protein P6; Region: PHA01399
541229014562	Phage-related protein [Function unknown]; Region: COG5412
541229014563	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
541229014564	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
541229014565	Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135
541229014566	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
541229014567	Phage capsid family; Region: Phage_capsid; pfam05065
541229014568	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
541229014569	Phage portal protein; Region: Phage_portal; pfam04860
541229014570	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
541229014571	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
541229014572	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
541229014573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229014574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229014575	Walker A motif; other site
541229014576	ATP binding site [chemical binding]; other site
541229014577	Walker B motif; other site
541229014578	arginine finger; other site
541229014579	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
541229014580	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
541229014581	ORF6C domain; Region: ORF6C; pfam10552
541229014582	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229014583	non-specific DNA binding site [nucleotide binding]; other site
541229014584	salt bridge; other site
541229014585	sequence-specific DNA binding site [nucleotide binding]; other site
541229014586	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229014587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229014588	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229014589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229014590	non-specific DNA binding site [nucleotide binding]; other site
541229014591	salt bridge; other site
541229014592	sequence-specific DNA binding site [nucleotide binding]; other site
541229014593	integrase; Provisional; Region: int; PHA02601
541229014594	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
541229014595	Int/Topo IB signature motif; other site
541229014596	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
541229014597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
541229014598	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229014599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229014600	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
541229014601	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
541229014602	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
541229014603	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
541229014604	hypothetical protein; Provisional; Region: PRK13669
541229014605	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
541229014606	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229014607	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
541229014608	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229014609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229014610	Walker A/P-loop; other site
541229014611	ATP binding site [chemical binding]; other site
541229014612	Q-loop/lid; other site
541229014613	ABC transporter signature motif; other site
541229014614	Walker B; other site
541229014615	D-loop; other site
541229014616	H-loop/switch region; other site
541229014617	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
541229014618	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
541229014619	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
541229014620	PhnA protein; Region: PhnA; pfam03831
541229014621	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
541229014622	CAAX protease self-immunity; Region: Abi; pfam02517
541229014623	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
541229014624	active site
541229014625	NTP binding site [chemical binding]; other site
541229014626	metal binding triad [ion binding]; metal-binding site
541229014627	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
541229014628	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
541229014629	NifU-like domain; Region: NifU; pfam01106
541229014630	spore coat protein YutH; Region: spore_yutH; TIGR02905
541229014631	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
541229014632	tetramer interfaces [polypeptide binding]; other site
541229014633	binuclear metal-binding site [ion binding]; other site
541229014634	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229014635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229014636	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
541229014637	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229014638	active site
541229014639	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
541229014640	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
541229014641	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
541229014642	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
541229014643	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229014644	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
541229014645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229014646	active site
541229014647	motif I; other site
541229014648	motif II; other site
541229014649	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229014650	Predicted transcriptional regulator [Transcription]; Region: COG2345
541229014651	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229014652	putative Zn2+ binding site [ion binding]; other site
541229014653	putative DNA binding site [nucleotide binding]; other site
541229014654	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
541229014655	Uncharacterized conserved protein [Function unknown]; Region: COG2445
541229014656	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
541229014657	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
541229014658	putative active site [active]
541229014659	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
541229014660	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
541229014661	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229014662	RNA binding surface [nucleotide binding]; other site
541229014663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229014664	Coenzyme A binding pocket [chemical binding]; other site
541229014665	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
541229014666	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
541229014667	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
541229014668	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
541229014669	DNA binding residues [nucleotide binding]
541229014670	dimer interface [polypeptide binding]; other site
541229014671	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
541229014672	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
541229014673	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
541229014674	catalytic core [active]
541229014675	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
541229014676	putative deacylase active site [active]
541229014677	lipoyl synthase; Provisional; Region: PRK05481
541229014678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229014679	FeS/SAM binding site; other site
541229014680	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229014681	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229014682	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
541229014683	Uncharacterized conserved protein [Function unknown]; Region: COG3377
541229014684	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
541229014685	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
541229014686	active site
541229014687	metal binding site [ion binding]; metal-binding site
541229014688	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
541229014689	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
541229014690	FeS assembly protein SufB; Region: sufB; TIGR01980
541229014691	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
541229014692	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
541229014693	trimerization site [polypeptide binding]; other site
541229014694	active site
541229014695	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
541229014696	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
541229014697	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
541229014698	catalytic residue [active]
541229014699	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
541229014700	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
541229014701	FeS assembly protein SufD; Region: sufD; TIGR01981
541229014702	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
541229014703	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
541229014704	Walker A/P-loop; other site
541229014705	ATP binding site [chemical binding]; other site
541229014706	Q-loop/lid; other site
541229014707	ABC transporter signature motif; other site
541229014708	Walker B; other site
541229014709	D-loop; other site
541229014710	H-loop/switch region; other site
541229014711	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
541229014712	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
541229014713	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
541229014714	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
541229014715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
541229014716	ABC-ATPase subunit interface; other site
541229014717	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
541229014718	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
541229014719	Walker A/P-loop; other site
541229014720	ATP binding site [chemical binding]; other site
541229014721	Q-loop/lid; other site
541229014722	ABC transporter signature motif; other site
541229014723	Walker B; other site
541229014724	D-loop; other site
541229014725	H-loop/switch region; other site
541229014726	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
541229014727	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
541229014728	catalytic residues [active]
541229014729	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
541229014730	putative active site [active]
541229014731	putative metal binding site [ion binding]; other site
541229014732	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
541229014733	lipoyl attachment site [posttranslational modification]; other site
541229014734	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
541229014735	ArsC family; Region: ArsC; pfam03960
541229014736	putative ArsC-like catalytic residues; other site
541229014737	putative TRX-like catalytic residues [active]
541229014738	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
541229014739	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
541229014740	active site
541229014741	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
541229014742	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
541229014743	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229014744	NAD binding site [chemical binding]; other site
541229014745	dimer interface [polypeptide binding]; other site
541229014746	substrate binding site [chemical binding]; other site
541229014747	Coat F domain; Region: Coat_F; pfam07875
541229014748	CAAX protease self-immunity; Region: Abi; pfam02517
541229014749	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229014750	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229014751	WHG domain; Region: WHG; pfam13305
541229014752	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
541229014753	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
541229014754	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
541229014755	active site
541229014756	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
541229014757	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
541229014758	dimer interface [polypeptide binding]; other site
541229014759	active site
541229014760	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
541229014761	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
541229014762	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
541229014763	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
541229014764	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
541229014765	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
541229014766	substrate binding site [chemical binding]; other site
541229014767	oxyanion hole (OAH) forming residues; other site
541229014768	YuzL-like protein; Region: YuzL; pfam14115
541229014769	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229014770	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
541229014771	Proline dehydrogenase; Region: Pro_dh; cl03282
541229014772	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
541229014773	Domain of unknown function DUF77; Region: DUF77; pfam01910
541229014774	Cache domain; Region: Cache_1; pfam02743
541229014775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229014776	dimerization interface [polypeptide binding]; other site
541229014777	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229014778	dimer interface [polypeptide binding]; other site
541229014779	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229014780	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229014781	dimer interface [polypeptide binding]; other site
541229014782	putative CheW interface [polypeptide binding]; other site
541229014783	Predicted transcriptional regulators [Transcription]; Region: COG1378
541229014784	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
541229014785	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
541229014786	C-terminal domain interface [polypeptide binding]; other site
541229014787	sugar binding site [chemical binding]; other site
541229014788	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229014789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229014790	putative substrate translocation pore; other site
541229014791	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
541229014792	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
541229014793	OxaA-like protein precursor; Validated; Region: PRK01622
541229014794	Uncharacterized conserved protein [Function unknown]; Region: COG1284
541229014795	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
541229014796	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
541229014797	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
541229014798	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229014799	hypothetical protein; Provisional; Region: PRK06758
541229014800	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
541229014801	active site
541229014802	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229014803	non-specific DNA binding site [nucleotide binding]; other site
541229014804	salt bridge; other site
541229014805	sequence-specific DNA binding site [nucleotide binding]; other site
541229014806	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229014807	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229014808	Protein of unknown function (DUF3978); Region: DUF3978; pfam13123
541229014809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
541229014810	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
541229014811	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229014812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229014813	active site
541229014814	phosphorylation site [posttranslational modification]
541229014815	intermolecular recognition site; other site
541229014816	dimerization interface [polypeptide binding]; other site
541229014817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229014818	DNA binding site [nucleotide binding]
541229014819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
541229014820	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229014821	dimer interface [polypeptide binding]; other site
541229014822	phosphorylation site [posttranslational modification]
541229014823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229014824	ATP binding site [chemical binding]; other site
541229014825	Mg2+ binding site [ion binding]; other site
541229014826	G-X-G motif; other site
541229014827	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
541229014828	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
541229014829	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
541229014830	active site
541229014831	HIGH motif; other site
541229014832	KMSKS motif; other site
541229014833	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
541229014834	tRNA binding surface [nucleotide binding]; other site
541229014835	anticodon binding site; other site
541229014836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229014837	S-adenosylmethionine binding site [chemical binding]; other site
541229014838	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
541229014839	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229014840	dimerization interface [polypeptide binding]; other site
541229014841	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229014842	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229014843	dimer interface [polypeptide binding]; other site
541229014844	putative CheW interface [polypeptide binding]; other site
541229014845	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
541229014846	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229014847	dimerization interface [polypeptide binding]; other site
541229014848	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229014849	dimer interface [polypeptide binding]; other site
541229014850	putative CheW interface [polypeptide binding]; other site
541229014851	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
541229014852	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229014853	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229014854	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
541229014855	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
541229014856	active site
541229014857	Zn binding site [ion binding]; other site
541229014858	Pirin-related protein [General function prediction only]; Region: COG1741
541229014859	Pirin; Region: Pirin; pfam02678
541229014860	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
541229014861	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
541229014862	MarR family; Region: MarR_2; pfam12802
541229014863	Protein of unknown function (DUF3920); Region: DUF3920; pfam13058
541229014864	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
541229014865	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
541229014866	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
541229014867	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
541229014868	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
541229014869	TrkA-C domain; Region: TrkA_C; pfam02080
541229014870	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229014871	amino acid carrier protein; Region: agcS; TIGR00835
541229014872	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
541229014873	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
541229014874	dimerization interface [polypeptide binding]; other site
541229014875	DPS ferroxidase diiron center [ion binding]; other site
541229014876	ion pore; other site
541229014877	DinB family; Region: DinB; cl17821
541229014878	DinB superfamily; Region: DinB_2; pfam12867
541229014879	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
541229014880	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
541229014881	metal binding site [ion binding]; metal-binding site
541229014882	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
541229014883	Ferritin-like domain; Region: Ferritin; pfam00210
541229014884	ferroxidase diiron center [ion binding]; other site
541229014885	Predicted membrane protein [Function unknown]; Region: COG2311
541229014886	Protein of unknown function (DUF418); Region: DUF418; cl12135
541229014887	Protein of unknown function (DUF418); Region: DUF418; pfam04235
541229014888	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229014889	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229014890	Nucleoside recognition; Region: Gate; pfam07670
541229014891	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229014892	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229014893	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229014894	Nucleoside recognition; Region: Gate; pfam07670
541229014895	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229014896	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229014897	amino acid carrier protein; Region: agcS; TIGR00835
541229014898	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
541229014899	amino acid carrier protein; Region: agcS; TIGR00835
541229014900	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
541229014901	NADH(P)-binding; Region: NAD_binding_10; pfam13460
541229014902	NAD binding site [chemical binding]; other site
541229014903	substrate binding site [chemical binding]; other site
541229014904	putative active site [active]
541229014905	Peptidase M60-like family; Region: M60-like; pfam13402
541229014906	Viral enhancin protein; Region: Enhancin; pfam03272
541229014907	TQXA domain; Region: TQXA_dom; TIGR03934
541229014908	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
541229014909	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
541229014910	active site
541229014911	catalytic tetrad [active]
541229014912	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
541229014913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229014914	putative substrate translocation pore; other site
541229014915	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229014916	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229014917	dimerization interface [polypeptide binding]; other site
541229014918	putative DNA binding site [nucleotide binding]; other site
541229014919	putative Zn2+ binding site [ion binding]; other site
541229014920	Uncharacterized conserved protein [Function unknown]; Region: COG2427
541229014921	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
541229014922	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229014923	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
541229014924	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
541229014925	active site
541229014926	HIGH motif; other site
541229014927	dimer interface [polypeptide binding]; other site
541229014928	KMSKS motif; other site
541229014929	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
541229014930	RNA binding surface [nucleotide binding]; other site
541229014931	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436
541229014932	FAD binding domain; Region: FAD_binding_4; pfam01565
541229014933	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
541229014934	SET domain; Region: SET; pfam00856
541229014935	Domain of unknown function (DUF4077); Region: DUF4077; pfam13295
541229014936	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229014937	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229014938	dimer interface [polypeptide binding]; other site
541229014939	putative CheW interface [polypeptide binding]; other site
541229014940	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
541229014941	putative phosphate binding site [ion binding]; other site
541229014942	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
541229014943	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
541229014944	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
541229014945	camphor resistance protein CrcB; Provisional; Region: PRK14219
541229014946	camphor resistance protein CrcB; Provisional; Region: PRK14205
541229014947	Protein of unknown function (DUF3947); Region: DUF3947; pfam13135
541229014948	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
541229014949	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
541229014950	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
541229014951	Coenzyme A binding pocket [chemical binding]; other site
541229014952	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
541229014953	Nuclease-related domain; Region: NERD; pfam08378
541229014954	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
541229014955	Isochorismatase family; Region: Isochorismatase; pfam00857
541229014956	catalytic triad [active]
541229014957	conserved cis-peptide bond; other site
541229014958	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
541229014959	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229014960	putative DNA binding site [nucleotide binding]; other site
541229014961	putative Zn2+ binding site [ion binding]; other site
541229014962	AsnC family; Region: AsnC_trans_reg; pfam01037
541229014963	MarR family; Region: MarR_2; pfam12802
541229014964	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
541229014965	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
541229014966	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
541229014967	Walker A/P-loop; other site
541229014968	ATP binding site [chemical binding]; other site
541229014969	Q-loop/lid; other site
541229014970	ABC transporter signature motif; other site
541229014971	Walker B; other site
541229014972	D-loop; other site
541229014973	H-loop/switch region; other site
541229014974	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229014975	ABC-ATPase subunit  interface; other site
541229014976	dimer interface [polypeptide binding]; other site
541229014977	putative PBP binding regions; other site
541229014978	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229014979	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229014980	ABC-ATPase subunit  interface; other site
541229014981	dimer interface [polypeptide binding]; other site
541229014982	putative PBP binding regions; other site
541229014983	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
541229014984	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
541229014985	putative ligand binding residues [chemical binding]; other site
541229014986	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229014987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229014988	active site
541229014989	phosphorylation site [posttranslational modification]
541229014990	intermolecular recognition site; other site
541229014991	dimerization interface [polypeptide binding]; other site
541229014992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229014993	DNA binding site [nucleotide binding]
541229014994	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
541229014995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
541229014996	Coenzyme A binding pocket [chemical binding]; other site
541229014997	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
541229014998	SmpB-tmRNA interface; other site
541229014999	ribonuclease R; Region: RNase_R; TIGR02063
541229015000	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
541229015001	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
541229015002	RNB domain; Region: RNB; pfam00773
541229015003	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
541229015004	RNA binding site [nucleotide binding]; other site
541229015005	Esterase/lipase [General function prediction only]; Region: COG1647
541229015006	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
541229015007	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
541229015008	holin-like protein; Validated; Region: PRK01658
541229015009	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455
541229015010	active site
541229015011	enolase; Provisional; Region: eno; PRK00077
541229015012	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
541229015013	dimer interface [polypeptide binding]; other site
541229015014	metal binding site [ion binding]; metal-binding site
541229015015	substrate binding pocket [chemical binding]; other site
541229015016	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
541229015017	phosphoglyceromutase; Provisional; Region: PRK05434
541229015018	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
541229015019	triosephosphate isomerase; Provisional; Region: PRK14565
541229015020	substrate binding site [chemical binding]; other site
541229015021	dimer interface [polypeptide binding]; other site
541229015022	catalytic triad [active]
541229015023	Phosphoglycerate kinase; Region: PGK; pfam00162
541229015024	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
541229015025	substrate binding site [chemical binding]; other site
541229015026	hinge regions; other site
541229015027	ADP binding site [chemical binding]; other site
541229015028	catalytic site [active]
541229015029	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
541229015030	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
541229015031	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
541229015032	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
541229015033	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
541229015034	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
541229015035	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
541229015036	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
541229015037	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
541229015038	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
541229015039	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229015040	Histidine kinase; Region: HisKA_3; pfam07730
541229015041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229015042	ATP binding site [chemical binding]; other site
541229015043	Mg2+ binding site [ion binding]; other site
541229015044	G-X-G motif; other site
541229015045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229015046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229015047	active site
541229015048	phosphorylation site [posttranslational modification]
541229015049	intermolecular recognition site; other site
541229015050	dimerization interface [polypeptide binding]; other site
541229015051	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229015052	DNA binding residues [nucleotide binding]
541229015053	dimerization interface [polypeptide binding]; other site
541229015054	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
541229015055	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
541229015056	stage V sporulation protein AD; Provisional; Region: PRK12404
541229015057	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
541229015058	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
541229015059	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
541229015060	Predicted membrane protein [Function unknown]; Region: COG2323
541229015061	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
541229015062	Clp protease; Region: CLP_protease; pfam00574
541229015063	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
541229015064	oligomer interface [polypeptide binding]; other site
541229015065	active site residues [active]
541229015066	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
541229015067	dimerization domain swap beta strand [polypeptide binding]; other site
541229015068	regulatory protein interface [polypeptide binding]; other site
541229015069	active site
541229015070	regulatory phosphorylation site [posttranslational modification]; other site
541229015071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
541229015072	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
541229015073	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
541229015074	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
541229015075	phosphate binding site [ion binding]; other site
541229015076	putative substrate binding pocket [chemical binding]; other site
541229015077	dimer interface [polypeptide binding]; other site
541229015078	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
541229015079	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
541229015080	putative active site [active]
541229015081	nucleotide binding site [chemical binding]; other site
541229015082	nudix motif; other site
541229015083	putative metal binding site [ion binding]; other site
541229015084	Domain of unknown function (DUF368); Region: DUF368; pfam04018
541229015085	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
541229015086	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
541229015087	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
541229015088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229015089	binding surface
541229015090	TPR motif; other site
541229015091	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229015092	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229015093	binding surface
541229015094	Tetratricopeptide repeat; Region: TPR_16; pfam13432
541229015095	TPR motif; other site
541229015096	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
541229015097	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
541229015098	trimer interface [polypeptide binding]; other site
541229015099	active site
541229015100	substrate binding site [chemical binding]; other site
541229015101	CoA binding site [chemical binding]; other site
541229015102	pyrophosphatase PpaX; Provisional; Region: PRK13288
541229015103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229015104	active site
541229015105	motif I; other site
541229015106	motif II; other site
541229015107	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
541229015108	HPr kinase/phosphorylase; Provisional; Region: PRK05428
541229015109	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
541229015110	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
541229015111	Hpr binding site; other site
541229015112	active site
541229015113	homohexamer subunit interaction site [polypeptide binding]; other site
541229015114	Predicted membrane protein [Function unknown]; Region: COG1950
541229015115	Domain of unknown function (DUF4275); Region: DUF4275; pfam14101
541229015116	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
541229015117	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
541229015118	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
541229015119	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
541229015120	excinuclease ABC subunit B; Provisional; Region: PRK05298
541229015121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229015122	ATP binding site [chemical binding]; other site
541229015123	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229015124	nucleotide binding region [chemical binding]; other site
541229015125	ATP-binding site [chemical binding]; other site
541229015126	Ultra-violet resistance protein B; Region: UvrB; pfam12344
541229015127	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
541229015128	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
541229015129	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229015130	DNA binding residues [nucleotide binding]
541229015131	dimer interface [polypeptide binding]; other site
541229015132	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
541229015133	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229015134	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229015135	non-specific DNA binding site [nucleotide binding]; other site
541229015136	salt bridge; other site
541229015137	sequence-specific DNA binding site [nucleotide binding]; other site
541229015138	Predicted membrane protein [Function unknown]; Region: COG2855
541229015139	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229015140	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229015141	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
541229015142	putative dimerization interface [polypeptide binding]; other site
541229015143	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
541229015144	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
541229015145	DNA binding residues [nucleotide binding]
541229015146	putative dimer interface [polypeptide binding]; other site
541229015147	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
541229015148	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
541229015149	hypothetical protein; Provisional; Region: PRK12855
541229015150	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
541229015151	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
541229015152	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
541229015153	Walker A/P-loop; other site
541229015154	ATP binding site [chemical binding]; other site
541229015155	Q-loop/lid; other site
541229015156	ABC transporter signature motif; other site
541229015157	Walker B; other site
541229015158	D-loop; other site
541229015159	H-loop/switch region; other site
541229015160	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
541229015161	protein binding site [polypeptide binding]; other site
541229015162	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
541229015163	C-terminal peptidase (prc); Region: prc; TIGR00225
541229015164	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
541229015165	protein binding site [polypeptide binding]; other site
541229015166	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
541229015167	Catalytic dyad [active]
541229015168	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
541229015169	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
541229015170	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
541229015171	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
541229015172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229015173	Walker A/P-loop; other site
541229015174	ATP binding site [chemical binding]; other site
541229015175	Q-loop/lid; other site
541229015176	ABC transporter signature motif; other site
541229015177	Walker B; other site
541229015178	D-loop; other site
541229015179	H-loop/switch region; other site
541229015180	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
541229015181	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
541229015182	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
541229015183	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
541229015184	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
541229015185	nucleotide binding region [chemical binding]; other site
541229015186	ATP-binding site [chemical binding]; other site
541229015187	SEC-C motif; Region: SEC-C; pfam02810
541229015188	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
541229015189	30S subunit binding site; other site
541229015190	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
541229015191	DNA-binding site [nucleotide binding]; DNA binding site
541229015192	RNA-binding motif; other site
541229015193	comF family protein; Region: comF; TIGR00201
541229015194	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229015195	active site
541229015196	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
541229015197	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229015198	ATP binding site [chemical binding]; other site
541229015199	putative Mg++ binding site [ion binding]; other site
541229015200	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229015201	nucleotide binding region [chemical binding]; other site
541229015202	ATP-binding site [chemical binding]; other site
541229015203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
541229015204	Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304
541229015205	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229015206	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229015207	Predicted transcriptional regulators [Transcription]; Region: COG1733
541229015208	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
541229015209	dimerization interface [polypeptide binding]; other site
541229015210	putative DNA binding site [nucleotide binding]; other site
541229015211	putative Zn2+ binding site [ion binding]; other site
541229015212	EDD domain protein, DegV family; Region: DegV; TIGR00762
541229015213	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
541229015214	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
541229015215	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
541229015216	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
541229015217	Transcriptional regulator [Transcription]; Region: LytR; COG1316
541229015218	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
541229015219	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
541229015220	active site
541229015221	homodimer interface [polypeptide binding]; other site
541229015222	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
541229015223	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
541229015224	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
541229015225	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
541229015226	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
541229015227	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
541229015228	Mg++ binding site [ion binding]; other site
541229015229	putative catalytic motif [active]
541229015230	substrate binding site [chemical binding]; other site
541229015231	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
541229015232	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
541229015233	NodB motif; other site
541229015234	active site
541229015235	catalytic site [active]
541229015236	Zn binding site [ion binding]; other site
541229015237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
541229015238	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
541229015239	Walker A motif; other site
541229015240	ATP binding site [chemical binding]; other site
541229015241	Walker B motif; other site
541229015242	arginine finger; other site
541229015243	Transcriptional antiterminator [Transcription]; Region: COG3933
541229015244	PRD domain; Region: PRD; pfam00874
541229015245	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
541229015246	active pocket/dimerization site; other site
541229015247	active site
541229015248	phosphorylation site [posttranslational modification]
541229015249	PRD domain; Region: PRD; pfam00874
541229015250	A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754
541229015251	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
541229015252	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
541229015253	Chromate transporter; Region: Chromate_transp; pfam02417
541229015254	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
541229015255	putative active site [active]
541229015256	YdjC motif; other site
541229015257	Mg binding site [ion binding]; other site
541229015258	putative homodimer interface [polypeptide binding]; other site
541229015259	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
541229015260	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
541229015261	NAD binding site [chemical binding]; other site
541229015262	sugar binding site [chemical binding]; other site
541229015263	divalent metal binding site [ion binding]; other site
541229015264	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229015265	dimer interface [polypeptide binding]; other site
541229015266	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
541229015267	active site
541229015268	methionine cluster; other site
541229015269	phosphorylation site [posttranslational modification]
541229015270	metal binding site [ion binding]; metal-binding site
541229015271	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
541229015272	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
541229015273	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
541229015274	active site
541229015275	P-loop; other site
541229015276	phosphorylation site [posttranslational modification]
541229015277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229015278	S-adenosylmethionine binding site [chemical binding]; other site
541229015279	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706
541229015280	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
541229015281	methionine cluster; other site
541229015282	active site
541229015283	phosphorylation site [posttranslational modification]
541229015284	metal binding site [ion binding]; metal-binding site
541229015285	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
541229015286	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
541229015287	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
541229015288	active site
541229015289	P-loop; other site
541229015290	phosphorylation site [posttranslational modification]
541229015291	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
541229015292	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
541229015293	Acyltransferase family; Region: Acyl_transf_3; pfam01757
541229015294	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
541229015295	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
541229015296	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
541229015297	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
541229015298	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
541229015299	Predicted membrane protein [Function unknown]; Region: COG1511
541229015300	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
541229015301	Transcriptional regulator [Transcription]; Region: LysR; COG0583
541229015302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
541229015303	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
541229015304	putative dimerization interface [polypeptide binding]; other site
541229015305	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
541229015306	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
541229015307	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
541229015308	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
541229015309	transmembrane helices; other site
541229015310	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
541229015311	ThiC-associated domain; Region: ThiC-associated; pfam13667
541229015312	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
541229015313	L-lactate permease; Region: Lactate_perm; cl00701
541229015314	glycolate transporter; Provisional; Region: PRK09695
541229015315	Tic20-like protein; Region: Tic20; pfam09685
541229015316	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
541229015317	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
541229015318	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
541229015319	Sulfatase; Region: Sulfatase; pfam00884
541229015320	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
541229015321	homodimer interface [polypeptide binding]; other site
541229015322	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
541229015323	substrate-cofactor binding pocket; other site
541229015324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229015325	catalytic residue [active]
541229015326	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015327	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015328	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015329	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015330	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015331	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
541229015332	NlpC/P60 family; Region: NLPC_P60; pfam00877
541229015333	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
541229015334	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
541229015335	Nucleoside recognition; Region: Gate; pfam07670
541229015336	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
541229015337	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
541229015338	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
541229015339	DXD motif; other site
541229015340	BCCT family transporter; Region: BCCT; pfam02028
541229015341	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015342	Bacterial SH3 domain; Region: SH3_3; pfam08239
541229015343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
541229015344	Protein of unknown function (DUF3910); Region: DUF3910; pfam13049
541229015345	Predicted membrane protein [Function unknown]; Region: COG4640
541229015346	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
541229015347	Double zinc ribbon; Region: DZR; pfam12773
541229015348	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
541229015349	Double zinc ribbon; Region: DZR; pfam12773
541229015350	SNF2 Helicase protein; Region: DUF3670; pfam12419
541229015351	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
541229015352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
541229015353	ATP binding site [chemical binding]; other site
541229015354	putative Mg++ binding site [ion binding]; other site
541229015355	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229015356	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
541229015357	nucleotide binding region [chemical binding]; other site
541229015358	ATP-binding site [chemical binding]; other site
541229015359	Predicted integral membrane protein [Function unknown]; Region: COG5652
541229015360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
541229015361	Transposase; Region: DEDD_Tnp_IS110; pfam01548
541229015362	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
541229015363	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
541229015364	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
541229015365	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
541229015366	ComK protein; Region: ComK; cl11560
541229015367	RNA polymerase factor sigma-70; Validated; Region: PRK06759
541229015368	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229015369	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229015370	DNA binding residues [nucleotide binding]
541229015371	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
541229015372	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
541229015373	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
541229015374	FtsX-like permease family; Region: FtsX; pfam02687
541229015375	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
541229015376	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
541229015377	Walker A/P-loop; other site
541229015378	ATP binding site [chemical binding]; other site
541229015379	Q-loop/lid; other site
541229015380	ABC transporter signature motif; other site
541229015381	Walker B; other site
541229015382	D-loop; other site
541229015383	H-loop/switch region; other site
541229015384	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
541229015385	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
541229015386	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
541229015387	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229015388	non-specific DNA binding site [nucleotide binding]; other site
541229015389	salt bridge; other site
541229015390	sequence-specific DNA binding site [nucleotide binding]; other site
541229015391	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
541229015392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229015393	putative substrate translocation pore; other site
541229015394	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
541229015395	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
541229015396	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
541229015397	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
541229015398	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229015399	dimerization interface [polypeptide binding]; other site
541229015400	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229015401	dimer interface [polypeptide binding]; other site
541229015402	phosphorylation site [posttranslational modification]
541229015403	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229015404	ATP binding site [chemical binding]; other site
541229015405	Mg2+ binding site [ion binding]; other site
541229015406	G-X-G motif; other site
541229015407	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229015408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229015409	active site
541229015410	phosphorylation site [posttranslational modification]
541229015411	intermolecular recognition site; other site
541229015412	dimerization interface [polypeptide binding]; other site
541229015413	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229015414	DNA binding site [nucleotide binding]
541229015415	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
541229015416	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
541229015417	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
541229015418	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
541229015419	active site
541229015420	phosphorylation site [posttranslational modification]
541229015421	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
541229015422	HTH domain; Region: HTH_11; pfam08279
541229015423	HTH domain; Region: HTH_11; pfam08279
541229015424	PRD domain; Region: PRD; pfam00874
541229015425	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
541229015426	active site
541229015427	P-loop; other site
541229015428	phosphorylation site [posttranslational modification]
541229015429	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
541229015430	active site
541229015431	phosphorylation site [posttranslational modification]
541229015432	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
541229015433	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
541229015434	NAD binding site [chemical binding]; other site
541229015435	homodimer interface [polypeptide binding]; other site
541229015436	active site
541229015437	substrate binding site [chemical binding]; other site
541229015438	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
541229015439	membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379
541229015440	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
541229015441	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
541229015442	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
541229015443	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
541229015444	active site
541229015445	Cupin domain; Region: Cupin_2; cl17218
541229015446	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229015447	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
541229015448	putative ADP-binding pocket [chemical binding]; other site
541229015449	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229015450	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
541229015451	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
541229015452	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229015453	putative homodimer interface [polypeptide binding]; other site
541229015454	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229015455	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
541229015456	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
541229015457	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
541229015458	trimer interface [polypeptide binding]; other site
541229015459	active site
541229015460	substrate binding site [chemical binding]; other site
541229015461	CoA binding site [chemical binding]; other site
541229015462	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
541229015463	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
541229015464	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
541229015465	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
541229015466	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
541229015467	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
541229015468	Bacterial sugar transferase; Region: Bac_transf; pfam02397
541229015469	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
541229015470	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
541229015471	active site
541229015472	tetramer interface; other site
541229015473	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
541229015474	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
541229015475	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
541229015476	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
541229015477	Chain length determinant protein; Region: Wzz; cl15801
541229015478	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
541229015479	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
541229015480	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
541229015481	rod shape-determining protein Mbl; Provisional; Region: PRK13928
541229015482	MreB and similar proteins; Region: MreB_like; cd10225
541229015483	nucleotide binding site [chemical binding]; other site
541229015484	Mg binding site [ion binding]; other site
541229015485	putative protofilament interaction site [polypeptide binding]; other site
541229015486	RodZ interaction site [polypeptide binding]; other site
541229015487	Stage III sporulation protein D; Region: SpoIIID; cl17560
541229015488	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
541229015489	Peptidase family M23; Region: Peptidase_M23; pfam01551
541229015490	CcmB protein; Region: CcmB; cl17444
541229015491	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
541229015492	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229015493	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229015494	Walker A/P-loop; other site
541229015495	ATP binding site [chemical binding]; other site
541229015496	Q-loop/lid; other site
541229015497	ABC transporter signature motif; other site
541229015498	Walker B; other site
541229015499	D-loop; other site
541229015500	H-loop/switch region; other site
541229015501	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
541229015502	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
541229015503	Q-loop/lid; other site
541229015504	ABC transporter signature motif; other site
541229015505	Walker B; other site
541229015506	D-loop; other site
541229015507	H-loop/switch region; other site
541229015508	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
541229015509	LytTr DNA-binding domain; Region: LytTR; pfam04397
541229015510	Stage II sporulation protein; Region: SpoIID; pfam08486
541229015511	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
541229015512	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
541229015513	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
541229015514	hinge; other site
541229015515	active site
541229015516	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
541229015517	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
541229015518	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
541229015519	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
541229015520	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
541229015521	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
541229015522	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
541229015523	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
541229015524	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
541229015525	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
541229015526	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
541229015527	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
541229015528	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
541229015529	4Fe-4S binding domain; Region: Fer4; cl02805
541229015530	4Fe-4S binding domain; Region: Fer4; pfam00037
541229015531	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
541229015532	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
541229015533	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
541229015534	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
541229015535	NADH dehydrogenase subunit C; Validated; Region: PRK07735
541229015536	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
541229015537	NADH dehydrogenase subunit B; Validated; Region: PRK06411
541229015538	NADH dehydrogenase subunit A; Validated; Region: PRK07756
541229015539	PAS domain S-box; Region: sensory_box; TIGR00229
541229015540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229015541	putative active site [active]
541229015542	heme pocket [chemical binding]; other site
541229015543	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229015544	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229015545	metal binding site [ion binding]; metal-binding site
541229015546	active site
541229015547	I-site; other site
541229015548	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229015549	Protein of unknown function (DUF975); Region: DUF975; cl10504
541229015550	Protein of unknown function (DUF975); Region: DUF975; cl10504
541229015551	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
541229015552	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
541229015553	gamma subunit interface [polypeptide binding]; other site
541229015554	epsilon subunit interface [polypeptide binding]; other site
541229015555	LBP interface [polypeptide binding]; other site
541229015556	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
541229015557	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
541229015558	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
541229015559	alpha subunit interaction interface [polypeptide binding]; other site
541229015560	Walker A motif; other site
541229015561	ATP binding site [chemical binding]; other site
541229015562	Walker B motif; other site
541229015563	inhibitor binding site; inhibition site
541229015564	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
541229015565	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
541229015566	core domain interface [polypeptide binding]; other site
541229015567	delta subunit interface [polypeptide binding]; other site
541229015568	epsilon subunit interface [polypeptide binding]; other site
541229015569	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
541229015570	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
541229015571	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
541229015572	beta subunit interaction interface [polypeptide binding]; other site
541229015573	Walker A motif; other site
541229015574	ATP binding site [chemical binding]; other site
541229015575	Walker B motif; other site
541229015576	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
541229015577	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
541229015578	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
541229015579	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
541229015580	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
541229015581	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
541229015582	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
541229015583	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
541229015584	ATP synthase I chain; Region: ATP_synt_I; pfam03899
541229015585	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
541229015586	Protein of unknown function (DUF4024); Region: DUF4024; pfam13216
541229015587	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
541229015588	active site
541229015589	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
541229015590	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
541229015591	dimer interface [polypeptide binding]; other site
541229015592	active site
541229015593	glycine-pyridoxal phosphate binding site [chemical binding]; other site
541229015594	folate binding site [chemical binding]; other site
541229015595	hypothetical protein; Provisional; Region: PRK13690
541229015596	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
541229015597	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
541229015598	Low molecular weight phosphatase family; Region: LMWPc; cd00115
541229015599	active site
541229015600	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
541229015601	HPr interaction site; other site
541229015602	glycerol kinase (GK) interaction site [polypeptide binding]; other site
541229015603	active site
541229015604	phosphorylation site [posttranslational modification]
541229015605	Predicted membrane protein [Function unknown]; Region: COG2259
541229015606	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
541229015607	Protein of unknown function (DUF3935); Region: DUF3935; pfam13071
541229015608	Predicted membrane protein [Function unknown]; Region: COG1971
541229015609	Domain of unknown function DUF; Region: DUF204; pfam02659
541229015610	Domain of unknown function DUF; Region: DUF204; pfam02659
541229015611	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
541229015612	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
541229015613	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
541229015614	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
541229015615	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
541229015616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229015617	S-adenosylmethionine binding site [chemical binding]; other site
541229015618	peptide chain release factor 1; Validated; Region: prfA; PRK00591
541229015619	This domain is found in peptide chain release factors; Region: PCRF; smart00937
541229015620	RF-1 domain; Region: RF-1; pfam00472
541229015621	thymidine kinase; Provisional; Region: PRK04296
541229015622	LabA_like proteins; Region: LabA_like/DUF88; cl10034
541229015623	putative metal binding site [ion binding]; other site
541229015624	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
541229015625	transcription termination factor Rho; Provisional; Region: rho; PRK09376
541229015626	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
541229015627	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
541229015628	RNA binding site [nucleotide binding]; other site
541229015629	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
541229015630	multimer interface [polypeptide binding]; other site
541229015631	Walker A motif; other site
541229015632	ATP binding site [chemical binding]; other site
541229015633	Walker B motif; other site
541229015634	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
541229015635	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
541229015636	putative active site [active]
541229015637	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
541229015638	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
541229015639	hinge; other site
541229015640	active site
541229015641	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
541229015642	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
541229015643	intersubunit interface [polypeptide binding]; other site
541229015644	active site
541229015645	zinc binding site [ion binding]; other site
541229015646	Na+ binding site [ion binding]; other site
541229015647	Response regulator receiver domain; Region: Response_reg; pfam00072
541229015648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229015649	active site
541229015650	phosphorylation site [posttranslational modification]
541229015651	intermolecular recognition site; other site
541229015652	dimerization interface [polypeptide binding]; other site
541229015653	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
541229015654	CTP synthetase; Validated; Region: pyrG; PRK05380
541229015655	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
541229015656	Catalytic site [active]
541229015657	active site
541229015658	UTP binding site [chemical binding]; other site
541229015659	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
541229015660	active site
541229015661	putative oxyanion hole; other site
541229015662	catalytic triad [active]
541229015663	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
541229015664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229015665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229015666	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
541229015667	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
541229015668	FAD binding site [chemical binding]; other site
541229015669	homotetramer interface [polypeptide binding]; other site
541229015670	substrate binding pocket [chemical binding]; other site
541229015671	catalytic base [active]
541229015672	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
541229015673	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
541229015674	FAD binding site [chemical binding]; other site
541229015675	homotetramer interface [polypeptide binding]; other site
541229015676	substrate binding pocket [chemical binding]; other site
541229015677	catalytic base [active]
541229015678	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
541229015679	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
541229015680	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
541229015681	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
541229015682	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
541229015683	dimer interface [polypeptide binding]; other site
541229015684	active site
541229015685	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
541229015686	4Fe-4S binding domain; Region: Fer4; cl02805
541229015687	Cysteine-rich domain; Region: CCG; pfam02754
541229015688	Cysteine-rich domain; Region: CCG; pfam02754
541229015689	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
541229015690	PLD-like domain; Region: PLDc_2; pfam13091
541229015691	putative active site [active]
541229015692	catalytic site [active]
541229015693	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
541229015694	PLD-like domain; Region: PLDc_2; pfam13091
541229015695	putative active site [active]
541229015696	catalytic site [active]
541229015697	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
541229015698	Domain of unknown function (DUF4084); Region: DUF4084; pfam13321
541229015699	PAS domain S-box; Region: sensory_box; TIGR00229
541229015700	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229015701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229015702	metal binding site [ion binding]; metal-binding site
541229015703	active site
541229015704	I-site; other site
541229015705	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
541229015706	Bacillus PapR protein; Region: Bacillus_PapR; pfam05968
541229015707	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
541229015708	non-specific DNA binding site [nucleotide binding]; other site
541229015709	salt bridge; other site
541229015710	sequence-specific DNA binding site [nucleotide binding]; other site
541229015711	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
541229015712	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
541229015713	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
541229015714	active site
541229015715	Zn binding site [ion binding]; other site
541229015716	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229015717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229015718	active site
541229015719	phosphorylation site [posttranslational modification]
541229015720	intermolecular recognition site; other site
541229015721	dimerization interface [polypeptide binding]; other site
541229015722	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229015723	DNA binding residues [nucleotide binding]
541229015724	dimerization interface [polypeptide binding]; other site
541229015725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229015726	Histidine kinase; Region: HisKA_3; pfam07730
541229015727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229015728	ATP binding site [chemical binding]; other site
541229015729	Mg2+ binding site [ion binding]; other site
541229015730	G-X-G motif; other site
541229015731	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
541229015732	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
541229015733	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229015734	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
541229015735	Walker A/P-loop; other site
541229015736	ATP binding site [chemical binding]; other site
541229015737	Q-loop/lid; other site
541229015738	ABC transporter signature motif; other site
541229015739	Walker B; other site
541229015740	D-loop; other site
541229015741	H-loop/switch region; other site
541229015742	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
541229015743	active site
541229015744	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
541229015745	Collagen binding domain; Region: Collagen_bind; pfam05737
541229015746	Collagen binding domain; Region: Collagen_bind; pfam05737
541229015747	Collagen binding domain; Region: Collagen_bind; pfam05737
541229015748	Collagen binding domain; Region: Collagen_bind; pfam05737
541229015749	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015750	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015751	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015752	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015753	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015754	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015755	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015756	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
541229015757	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015758	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015759	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015760	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015761	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
541229015762	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015763	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015764	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015765	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015766	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015767	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015768	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
541229015769	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015770	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015771	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015772	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015773	Cna protein B-type domain; Region: Cna_B; pfam05738
541229015774	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
541229015775	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
541229015776	PA/protease or protease-like domain interface [polypeptide binding]; other site
541229015777	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
541229015778	Peptidase family M28; Region: Peptidase_M28; pfam04389
541229015779	metal binding site [ion binding]; metal-binding site
541229015780	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
541229015781	RNA polymerase sigma factor; Provisional; Region: PRK12522
541229015782	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
541229015783	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
541229015784	DNA binding residues [nucleotide binding]
541229015785	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
541229015786	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
541229015787	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
541229015788	active site
541229015789	HIGH motif; other site
541229015790	KMSK motif region; other site
541229015791	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
541229015792	tRNA binding surface [nucleotide binding]; other site
541229015793	anticodon binding site; other site
541229015794	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
541229015795	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
541229015796	putative dimer interface [polypeptide binding]; other site
541229015797	catalytic triad [active]
541229015798	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
541229015799	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
541229015800	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
541229015801	agmatinase; Region: agmatinase; TIGR01230
541229015802	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
541229015803	putative active site [active]
541229015804	Mn binding site [ion binding]; other site
541229015805	spermidine synthase; Provisional; Region: PRK00811
541229015806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229015807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229015808	Major Facilitator Superfamily; Region: MFS_1; pfam07690
541229015809	putative substrate translocation pore; other site
541229015810	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
541229015811	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
541229015812	DNA binding residues [nucleotide binding]
541229015813	putative dimer interface [polypeptide binding]; other site
541229015814	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
541229015815	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
541229015816	active site
541229015817	catalytic site [active]
541229015818	metal binding site [ion binding]; metal-binding site
541229015819	dimer interface [polypeptide binding]; other site
541229015820	Transglycosylase; Region: Transgly; pfam00912
541229015821	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
541229015822	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
541229015823	YwhD family; Region: YwhD; pfam08741
541229015824	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
541229015825	Peptidase family M50; Region: Peptidase_M50; pfam02163
541229015826	active site
541229015827	putative substrate binding region [chemical binding]; other site
541229015828	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
541229015829	active site 1 [active]
541229015830	dimer interface [polypeptide binding]; other site
541229015831	hexamer interface [polypeptide binding]; other site
541229015832	active site 2 [active]
541229015833	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
541229015834	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
541229015835	Zn2+ binding site [ion binding]; other site
541229015836	Mg2+ binding site [ion binding]; other site
541229015837	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
541229015838	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
541229015839	intersubunit interface [polypeptide binding]; other site
541229015840	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
541229015841	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
541229015842	Walker A/P-loop; other site
541229015843	ATP binding site [chemical binding]; other site
541229015844	Q-loop/lid; other site
541229015845	ABC transporter signature motif; other site
541229015846	Walker B; other site
541229015847	D-loop; other site
541229015848	H-loop/switch region; other site
541229015849	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
541229015850	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229015851	ABC-ATPase subunit  interface; other site
541229015852	dimer interface [polypeptide binding]; other site
541229015853	putative PBP binding regions; other site
541229015854	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
541229015855	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
541229015856	ABC-ATPase subunit  interface; other site
541229015857	dimer interface [polypeptide binding]; other site
541229015858	putative PBP binding regions; other site
541229015859	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
541229015860	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
541229015861	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
541229015862	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
541229015863	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
541229015864	putative heme peroxidase; Provisional; Region: PRK12276
541229015865	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
541229015866	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
541229015867	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
541229015868	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
541229015869	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
541229015870	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
541229015871	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
541229015872	Ion channel; Region: Ion_trans_2; pfam07885
541229015873	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
541229015874	TrkA-N domain; Region: TrkA_N; pfam02254
541229015875	TrkA-C domain; Region: TrkA_C; pfam02080
541229015876	putative uracil/xanthine transporter; Provisional; Region: PRK11412
541229015877	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
541229015878	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229015879	motif II; other site
541229015880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229015881	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
541229015882	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
541229015883	ligand binding site [chemical binding]; other site
541229015884	active site
541229015885	UGI interface [polypeptide binding]; other site
541229015886	catalytic site [active]
541229015887	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
541229015888	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
541229015889	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
541229015890	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
541229015891	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
541229015892	Walker A/P-loop; other site
541229015893	ATP binding site [chemical binding]; other site
541229015894	Q-loop/lid; other site
541229015895	ABC transporter signature motif; other site
541229015896	Walker B; other site
541229015897	D-loop; other site
541229015898	H-loop/switch region; other site
541229015899	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
541229015900	active site
541229015901	catalytic triad [active]
541229015902	oxyanion hole [active]
541229015903	Transcriptional regulators [Transcription]; Region: PurR; COG1609
541229015904	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
541229015905	DNA binding site [nucleotide binding]
541229015906	domain linker motif; other site
541229015907	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
541229015908	putative dimerization interface [polypeptide binding]; other site
541229015909	putative ligand binding site [chemical binding]; other site
541229015910	Predicted membrane protein [Function unknown]; Region: COG2364
541229015911	homoserine dehydrogenase; Provisional; Region: PRK06349
541229015912	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
541229015913	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
541229015914	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
541229015915	Homoserine O-succinyltransferase; Region: HTS; pfam04204
541229015916	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
541229015917	proposed active site lysine [active]
541229015918	conserved cys residue [active]
541229015919	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702
541229015920	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
541229015921	homodimer interface [polypeptide binding]; other site
541229015922	substrate-cofactor binding pocket; other site
541229015923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
541229015924	catalytic residue [active]
541229015925	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
541229015926	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
541229015927	Cl- selectivity filter; other site
541229015928	Cl- binding residues [ion binding]; other site
541229015929	pore gating glutamate residue; other site
541229015930	dimer interface [polypeptide binding]; other site
541229015931	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
541229015932	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
541229015933	active site
541229015934	motif I; other site
541229015935	motif II; other site
541229015936	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
541229015937	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
541229015938	ligand binding site [chemical binding]; other site
541229015939	flexible hinge region; other site
541229015940	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
541229015941	azoreductase; Provisional; Region: PRK13556
541229015942	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
541229015943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229015944	active site
541229015945	phosphorylation site [posttranslational modification]
541229015946	intermolecular recognition site; other site
541229015947	dimerization interface [polypeptide binding]; other site
541229015948	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
541229015949	DNA binding residues [nucleotide binding]
541229015950	dimerization interface [polypeptide binding]; other site
541229015951	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
541229015952	GAF domain; Region: GAF; pfam01590
541229015953	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
541229015954	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
541229015955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
541229015956	Histidine kinase; Region: HisKA_3; pfam07730
541229015957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229015958	ATP binding site [chemical binding]; other site
541229015959	Mg2+ binding site [ion binding]; other site
541229015960	G-X-G motif; other site
541229015961	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
541229015962	dimer interface [polypeptide binding]; other site
541229015963	substrate binding site [chemical binding]; other site
541229015964	ATP binding site [chemical binding]; other site
541229015965	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
541229015966	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
541229015967	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
541229015968	metal binding site [ion binding]; metal-binding site
541229015969	active site
541229015970	I-site; other site
541229015971	Protein of unknown function (DUF466); Region: DUF466; pfam04328
541229015972	carbon starvation protein A; Provisional; Region: PRK15015
541229015973	Carbon starvation protein CstA; Region: CstA; pfam02554
541229015974	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
541229015975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229015976	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
541229015977	active site
541229015978	phosphorylation site [posttranslational modification]
541229015979	intermolecular recognition site; other site
541229015980	dimerization interface [polypeptide binding]; other site
541229015981	LytTr DNA-binding domain; Region: LytTR; pfam04397
541229015982	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
541229015983	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
541229015984	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
541229015985	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
541229015986	Predicted membrane protein [Function unknown]; Region: COG2860
541229015987	UPF0126 domain; Region: UPF0126; pfam03458
541229015988	UPF0126 domain; Region: UPF0126; pfam03458
541229015989	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
541229015990	heme-binding site [chemical binding]; other site
541229015991	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
541229015992	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229015993	dimer interface [polypeptide binding]; other site
541229015994	putative CheW interface [polypeptide binding]; other site
541229015995	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
541229015996	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
541229015997	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229015998	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
541229015999	Ligand binding site; other site
541229016000	Putative Catalytic site; other site
541229016001	DXD motif; other site
541229016002	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
541229016003	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
541229016004	active site
541229016005	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
541229016006	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
541229016007	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
541229016008	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
541229016009	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
541229016010	Ligand binding site; other site
541229016011	Putative Catalytic site; other site
541229016012	DXD motif; other site
541229016013	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
541229016014	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229016015	NAD(P) binding site [chemical binding]; other site
541229016016	active site
541229016017	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229016018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229016019	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
541229016020	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229016021	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229016022	ABC transporter; Region: ABC_tran_2; pfam12848
541229016023	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
541229016024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
541229016025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
541229016026	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
541229016027	Protein export membrane protein; Region: SecD_SecF; cl14618
541229016028	methionine sulfoxide reductase A; Provisional; Region: PRK14054
541229016029	methionine sulfoxide reductase B; Provisional; Region: PRK00222
541229016030	SelR domain; Region: SelR; pfam01641
541229016031	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
541229016032	antiholin-like protein LrgB; Provisional; Region: PRK04288
541229016033	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
541229016034	two-component response regulator; Provisional; Region: PRK14084
541229016035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229016036	active site
541229016037	phosphorylation site [posttranslational modification]
541229016038	intermolecular recognition site; other site
541229016039	dimerization interface [polypeptide binding]; other site
541229016040	LytTr DNA-binding domain; Region: LytTR; pfam04397
541229016041	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
541229016042	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
541229016043	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
541229016044	Histidine kinase; Region: His_kinase; pfam06580
541229016045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229016046	ATP binding site [chemical binding]; other site
541229016047	Mg2+ binding site [ion binding]; other site
541229016048	G-X-G motif; other site
541229016049	benzoate transport; Region: 2A0115; TIGR00895
541229016050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
541229016051	putative substrate translocation pore; other site
541229016052	BCCT family transporter; Region: BCCT; pfam02028
541229016053	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
541229016054	active site
541229016055	dimer interface [polypeptide binding]; other site
541229016056	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
541229016057	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
541229016058	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
541229016059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
541229016060	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
541229016061	NAD(P) binding site [chemical binding]; other site
541229016062	active site
541229016063	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
541229016064	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
541229016065	UDP-glucose 4-epimerase; Region: PLN02240
541229016066	NAD binding site [chemical binding]; other site
541229016067	homodimer interface [polypeptide binding]; other site
541229016068	active site
541229016069	substrate binding site [chemical binding]; other site
541229016070	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
541229016071	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
541229016072	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
541229016073	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
541229016074	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
541229016075	ATP binding site [chemical binding]; other site
541229016076	Mg++ binding site [ion binding]; other site
541229016077	motif III; other site
541229016078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
541229016079	nucleotide binding region [chemical binding]; other site
541229016080	ATP-binding site [chemical binding]; other site
541229016081	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
541229016082	RNA binding site [nucleotide binding]; other site
541229016083	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
541229016084	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
541229016085	active site
541229016086	oligoendopeptidase F; Region: pepF; TIGR00181
541229016087	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
541229016088	active site
541229016089	Zn binding site [ion binding]; other site
541229016090	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
541229016091	FeS/SAM binding site; other site
541229016092	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
541229016093	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
541229016094	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
541229016095	GAF domain; Region: GAF_3; pfam13492
541229016096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229016097	PAS domain; Region: PAS_9; pfam13426
541229016098	putative active site [active]
541229016099	heme pocket [chemical binding]; other site
541229016100	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229016101	dimer interface [polypeptide binding]; other site
541229016102	phosphorylation site [posttranslational modification]
541229016103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229016104	ATP binding site [chemical binding]; other site
541229016105	Mg2+ binding site [ion binding]; other site
541229016106	G-X-G motif; other site
541229016107	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
541229016108	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
541229016109	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
541229016110	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
541229016111	protein binding site [polypeptide binding]; other site
541229016112	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
541229016113	YycH protein; Region: YycI; pfam09648
541229016114	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
541229016115	YycH protein; Region: YycH; pfam07435
541229016116	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
541229016117	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
541229016118	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
541229016119	dimerization interface [polypeptide binding]; other site
541229016120	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
541229016121	putative active site [active]
541229016122	heme pocket [chemical binding]; other site
541229016123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
541229016124	dimer interface [polypeptide binding]; other site
541229016125	phosphorylation site [posttranslational modification]
541229016126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
541229016127	ATP binding site [chemical binding]; other site
541229016128	Mg2+ binding site [ion binding]; other site
541229016129	G-X-G motif; other site
541229016130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
541229016131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
541229016132	active site
541229016133	phosphorylation site [posttranslational modification]
541229016134	intermolecular recognition site; other site
541229016135	dimerization interface [polypeptide binding]; other site
541229016136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
541229016137	DNA binding site [nucleotide binding]
541229016138	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
541229016139	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
541229016140	GDP-binding site [chemical binding]; other site
541229016141	ACT binding site; other site
541229016142	IMP binding site; other site
541229016143	replicative DNA helicase; Provisional; Region: PRK05748
541229016144	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
541229016145	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
541229016146	Walker A motif; other site
541229016147	ATP binding site [chemical binding]; other site
541229016148	Walker B motif; other site
541229016149	DNA binding loops [nucleotide binding]
541229016150	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
541229016151	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
541229016152	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
541229016153	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
541229016154	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
541229016155	DHH family; Region: DHH; pfam01368
541229016156	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
541229016157	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
541229016158	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
541229016159	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
541229016160	dimer interface [polypeptide binding]; other site
541229016161	ssDNA binding site [nucleotide binding]; other site
541229016162	tetramer (dimer of dimers) interface [polypeptide binding]; other site
541229016163	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
541229016164	GTP-binding protein YchF; Reviewed; Region: PRK09601
541229016165	YchF GTPase; Region: YchF; cd01900
541229016166	G1 box; other site
541229016167	GTP/Mg2+ binding site [chemical binding]; other site
541229016168	Switch I region; other site
541229016169	G2 box; other site
541229016170	Switch II region; other site
541229016171	G3 box; other site
541229016172	G4 box; other site
541229016173	G5 box; other site
541229016174	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
541229016175	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
541229016176	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
541229016177	Mechanosensitive ion channel; Region: MS_channel; pfam00924
541229016178	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
541229016179	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
541229016180	ParB-like nuclease domain; Region: ParB; smart00470
541229016181	KorB domain; Region: KorB; pfam08535
541229016182	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
541229016183	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
541229016184	P-loop; other site
541229016185	Magnesium ion binding site [ion binding]; other site
541229016186	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
541229016187	Magnesium ion binding site [ion binding]; other site
541229016188	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
541229016189	ParB-like nuclease domain; Region: ParBc; pfam02195
541229016190	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
541229016191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
541229016192	S-adenosylmethionine binding site [chemical binding]; other site
541229016193	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
541229016194	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
541229016195	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
541229016196	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
541229016197	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
541229016198	trmE is a tRNA modification GTPase; Region: trmE; cd04164
541229016199	G1 box; other site
541229016200	GTP/Mg2+ binding site [chemical binding]; other site
541229016201	Switch I region; other site
541229016202	G2 box; other site
541229016203	Switch II region; other site
541229016204	G3 box; other site
541229016205	G4 box; other site
541229016206	G5 box; other site
541229016207	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
541229016208	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
541229016209	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
541229016210	G-X-X-G motif; other site
541229016211	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
541229016212	RxxxH motif; other site
541229016213	OxaA-like protein precursor; Validated; Region: PRK02944
541229016214	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
541229016215	ribonuclease P; Reviewed; Region: rnpA; PRK00499
541229016216	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
541229016217	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
541229016218	Interdomain contacts; other site
541229016219	Cytokine receptor motif; other site
541229016220	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
541229016221	Replication protein; Region: Rep_1; cl02412
541229016222	Replication initiation factor; Region: Rep_trans; pfam02486
541229016223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
541229016224	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
541229016225	Probable transposase; Region: OrfB_IS605; pfam01385
541229016226	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
541229016227	MarR family; Region: MarR_2; pfam12802
541229016228	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
541229016229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
541229016230	TPR motif; other site
541229016231	binding surface
541229016232	Tetratricopeptide repeat; Region: TPR_12; pfam13424
541229016233	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
541229016234	sequence-specific DNA binding site [nucleotide binding]; other site
541229016235	salt bridge; other site
541229016236	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
541229016237	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
541229016238	Replication protein; Region: Rep_1; cl02412
541229016239	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
541229016240	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
541229016241	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
541229016242	active site
541229016243	catalytic residues [active]
541229016244	DNA binding site [nucleotide binding]
541229016245	Int/Topo IB signature motif; other site
541229016246	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
541229016247	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
541229016248	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
541229016249	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
541229016250	non-specific DNA interactions [nucleotide binding]; other site
541229016251	DNA binding site [nucleotide binding]
541229016252	sequence specific DNA binding site [nucleotide binding]; other site
541229016253	putative cAMP binding site [chemical binding]; other site
541229016254	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076