-- dump date 20140618_235453 -- class Genbank::misc_feature -- table misc_feature_note -- id note 930170000001 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 930170000002 Condensation domain; Region: Condensation; pfam00668 930170000003 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 930170000004 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170000005 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 930170000006 acyl-activating enzyme (AAE) consensus motif; other site 930170000007 AMP binding site [chemical binding]; other site 930170000008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170000009 Condensation domain; Region: Condensation; pfam00668 930170000010 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 930170000011 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 930170000012 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170000013 acyl-activating enzyme (AAE) consensus motif; other site 930170000014 AMP binding site [chemical binding]; other site 930170000015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170000016 thioester reductase domain; Region: Thioester-redct; TIGR01746 930170000017 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 930170000018 putative NAD(P) binding site [chemical binding]; other site 930170000019 active site 930170000020 putative substrate binding site [chemical binding]; other site 930170000021 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 930170000022 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930170000023 catalytic residues [active] 930170000024 catalytic nucleophile [active] 930170000025 Presynaptic Site I dimer interface [polypeptide binding]; other site 930170000026 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930170000027 Synaptic Flat tetramer interface [polypeptide binding]; other site 930170000028 Synaptic Site I dimer interface [polypeptide binding]; other site 930170000029 DNA binding site [nucleotide binding] 930170000030 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170000031 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170000032 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930170000033 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930170000034 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170000035 Walker A/P-loop; other site 930170000036 ATP binding site [chemical binding]; other site 930170000037 Q-loop/lid; other site 930170000038 ABC transporter signature motif; other site 930170000039 Walker B; other site 930170000040 D-loop; other site 930170000041 H-loop/switch region; other site 930170000042 Integral membrane protein DUF95; Region: DUF95; pfam01944 930170000043 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 930170000044 active site 930170000045 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930170000046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 930170000047 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170000048 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170000049 Walker A/P-loop; other site 930170000050 ATP binding site [chemical binding]; other site 930170000051 Q-loop/lid; other site 930170000052 ABC transporter signature motif; other site 930170000053 Walker B; other site 930170000054 D-loop; other site 930170000055 H-loop/switch region; other site 930170000056 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930170000057 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170000058 FtsX-like permease family; Region: FtsX; pfam02687 930170000059 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 930170000060 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170000061 SprT-like family; Region: SprT-like; pfam10263 930170000062 CAAX protease self-immunity; Region: Abi; pfam02517 930170000063 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 930170000064 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930170000065 active site 930170000066 catalytic residues [active] 930170000067 DNA binding site [nucleotide binding] 930170000068 Int/Topo IB signature motif; other site 930170000069 Sm and related proteins; Region: Sm_like; cl00259 930170000070 heptamer interface [polypeptide binding]; other site 930170000071 Sm1 motif; other site 930170000072 hexamer interface [polypeptide binding]; other site 930170000073 RNA binding site [nucleotide binding]; other site 930170000074 Sm2 motif; other site 930170000075 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 930170000076 Mg binding site [ion binding]; other site 930170000077 nucleotide binding site [chemical binding]; other site 930170000078 putative protofilament interface [polypeptide binding]; other site 930170000079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170000080 TPR motif; other site 930170000081 binding surface 930170000082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170000083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170000084 non-specific DNA binding site [nucleotide binding]; other site 930170000085 salt bridge; other site 930170000086 sequence-specific DNA binding site [nucleotide binding]; other site 930170000087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170000088 non-specific DNA binding site [nucleotide binding]; other site 930170000089 salt bridge; other site 930170000090 sequence-specific DNA binding site [nucleotide binding]; other site 930170000091 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 930170000092 metal ion-dependent adhesion site (MIDAS); other site 930170000093 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000094 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000095 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000096 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000097 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000098 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000099 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000100 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000101 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170000102 AAA-like domain; Region: AAA_10; pfam12846 930170000103 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 930170000104 Replication-relaxation; Region: Replic_Relax; pfam13814 930170000105 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 930170000106 TcpE family; Region: TcpE; pfam12648 930170000107 AAA-like domain; Region: AAA_10; pfam12846 930170000108 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 930170000109 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170000110 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 930170000111 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170000112 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 930170000113 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930170000114 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 930170000115 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930170000116 cofactor binding site; other site 930170000117 DNA binding site [nucleotide binding] 930170000118 substrate interaction site [chemical binding]; other site 930170000119 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930170000120 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170000121 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170000122 putative active site [active] 930170000123 putative NTP binding site [chemical binding]; other site 930170000124 putative nucleic acid binding site [nucleotide binding]; other site 930170000125 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170000126 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 930170000127 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 930170000128 nucleotide binding site [chemical binding]; other site 930170000129 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170000130 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930170000131 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 930170000132 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 930170000133 putative DNA binding surface [nucleotide binding]; other site 930170000134 dimer interface [polypeptide binding]; other site 930170000135 beta-clamp/translesion DNA polymerase binding surface; other site 930170000136 beta-clamp/clamp loader binding surface; other site 930170000137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170000138 non-specific DNA binding site [nucleotide binding]; other site 930170000139 salt bridge; other site 930170000140 sequence-specific DNA binding site [nucleotide binding]; other site 930170000141 AAA domain; Region: AAA_31; pfam13614 930170000142 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 930170000143 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 930170000144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170000145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170000146 DNA binding residues [nucleotide binding] 930170000147 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170000148 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170000149 putative active site [active] 930170000150 putative NTP binding site [chemical binding]; other site 930170000151 putative nucleic acid binding site [nucleotide binding]; other site 930170000152 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930170000153 active site 930170000154 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 930170000155 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 930170000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170000157 Integrase core domain; Region: rve; pfam00665 930170000158 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930170000159 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930170000160 catalytic residues [active] 930170000161 catalytic nucleophile [active] 930170000162 Presynaptic Site I dimer interface [polypeptide binding]; other site 930170000163 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930170000164 Synaptic Flat tetramer interface [polypeptide binding]; other site 930170000165 Synaptic Site I dimer interface [polypeptide binding]; other site 930170000166 DNA binding site [nucleotide binding] 930170000167 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170000168 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 930170000169 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 930170000170 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170000171 active site 930170000172 DNA binding site [nucleotide binding] 930170000173 Int/Topo IB signature motif; other site 930170000174 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930170000175 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 930170000176 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 930170000177 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170000178 Spore germination protein; Region: Spore_permease; cl17796 930170000179 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170000180 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170000181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170000182 Integrase core domain; Region: rve; pfam00665 930170000183 Integrase core domain; Region: rve; pfam00665 930170000184 Integrase core domain; Region: rve_2; pfam13333 930170000185 Integrase core domain; Region: rve; pfam00665 930170000186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930170000187 Transposase; Region: HTH_Tnp_1; pfam01527 930170000188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170000189 Integrase core domain; Region: rve; pfam00665 930170000190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170000191 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930170000192 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170000193 DNA binding residues [nucleotide binding] 930170000194 Helix-turn-helix domain; Region: HTH_17; pfam12728 930170000195 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930170000196 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170000197 active site 930170000198 DNA binding site [nucleotide binding] 930170000199 Int/Topo IB signature motif; other site 930170000200 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 930170000201 delta endotoxin; Region: Endotoxin_M; pfam00555 930170000202 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 930170000203 putative metal binding site [ion binding]; other site 930170000204 potential frameshift: common BLAST hit: gi|169830964|ref|YP_001716946.1| phage integrase family protein 930170000205 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170000206 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170000207 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170000208 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 930170000209 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170000210 active site 930170000211 DNA binding site [nucleotide binding] 930170000212 Int/Topo IB signature motif; other site 930170000213 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170000214 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170000215 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 930170000216 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 930170000217 PhnA protein; Region: PhnA; pfam03831 930170000218 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 930170000219 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 930170000220 putative transporter; Provisional; Region: PRK11660 930170000221 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930170000222 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930170000223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170000224 dimerization interface [polypeptide binding]; other site 930170000225 putative DNA binding site [nucleotide binding]; other site 930170000226 putative Zn2+ binding site [ion binding]; other site 930170000227 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930170000228 putative active site [active] 930170000229 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930170000230 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930170000231 catalytic residues [active] 930170000232 catalytic nucleophile [active] 930170000233 Presynaptic Site I dimer interface [polypeptide binding]; other site 930170000234 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930170000235 Synaptic Flat tetramer interface [polypeptide binding]; other site 930170000236 Synaptic Site I dimer interface [polypeptide binding]; other site 930170000237 DNA binding site [nucleotide binding] 930170000238 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930170000239 DNA-binding interface [nucleotide binding]; DNA binding site 930170000240 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170000241 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170000242 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930170000243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930170000244 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930170000245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170000246 dimerization interface [polypeptide binding]; other site 930170000247 putative DNA binding site [nucleotide binding]; other site 930170000248 putative Zn2+ binding site [ion binding]; other site 930170000249 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930170000250 bacterial Hfq-like; Region: Hfq; cd01716 930170000251 hexamer interface [polypeptide binding]; other site 930170000252 Sm1 motif; other site 930170000253 RNA binding site [nucleotide binding]; other site 930170000254 Sm2 motif; other site 930170000255 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 930170000256 DnaA N-terminal domain; Region: DnaA_N; pfam11638 930170000257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170000258 Walker A motif; other site 930170000259 ATP binding site [chemical binding]; other site 930170000260 Walker B motif; other site 930170000261 arginine finger; other site 930170000262 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 930170000263 DnaA box-binding interface [nucleotide binding]; other site 930170000264 DNA polymerase III subunit beta; Validated; Region: PRK05643 930170000265 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 930170000266 putative DNA binding surface [nucleotide binding]; other site 930170000267 dimer interface [polypeptide binding]; other site 930170000268 beta-clamp/clamp loader binding surface; other site 930170000269 beta-clamp/translesion DNA polymerase binding surface; other site 930170000270 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 930170000271 recombination protein F; Reviewed; Region: recF; PRK00064 930170000272 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 930170000273 Walker A/P-loop; other site 930170000274 ATP binding site [chemical binding]; other site 930170000275 Q-loop/lid; other site 930170000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170000277 ABC transporter signature motif; other site 930170000278 Walker B; other site 930170000279 D-loop; other site 930170000280 H-loop/switch region; other site 930170000281 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 930170000282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170000283 Mg2+ binding site [ion binding]; other site 930170000284 G-X-G motif; other site 930170000285 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930170000286 anchoring element; other site 930170000287 dimer interface [polypeptide binding]; other site 930170000288 ATP binding site [chemical binding]; other site 930170000289 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930170000290 active site 930170000291 putative metal-binding site [ion binding]; other site 930170000292 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930170000293 DNA gyrase subunit A; Validated; Region: PRK05560 930170000294 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930170000295 CAP-like domain; other site 930170000296 active site 930170000297 primary dimer interface [polypeptide binding]; other site 930170000298 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170000299 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170000300 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170000301 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170000302 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170000303 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170000304 YaaC-like Protein; Region: YaaC; pfam14175 930170000305 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 930170000306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 930170000307 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 930170000308 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930170000309 active site 930170000310 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 930170000311 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170000312 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 930170000313 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 930170000314 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 930170000315 active site 930170000316 multimer interface [polypeptide binding]; other site 930170000317 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 930170000318 predicted active site [active] 930170000319 catalytic triad [active] 930170000320 seryl-tRNA synthetase; Provisional; Region: PRK05431 930170000321 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 930170000322 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 930170000323 dimer interface [polypeptide binding]; other site 930170000324 active site 930170000325 motif 1; other site 930170000326 motif 2; other site 930170000327 motif 3; other site 930170000328 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 930170000329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 930170000330 DNA binding residues [nucleotide binding] 930170000331 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 930170000332 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 930170000333 Substrate-binding site [chemical binding]; other site 930170000334 Substrate specificity [chemical binding]; other site 930170000335 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 930170000336 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 930170000337 Substrate-binding site [chemical binding]; other site 930170000338 Substrate specificity [chemical binding]; other site 930170000339 Isochorismatase family; Region: Isochorismatase; pfam00857 930170000340 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 930170000341 catalytic triad [active] 930170000342 conserved cis-peptide bond; other site 930170000343 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930170000344 nucleoside/Zn binding site; other site 930170000345 dimer interface [polypeptide binding]; other site 930170000346 catalytic motif [active] 930170000347 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 930170000348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170000349 Walker A motif; other site 930170000350 ATP binding site [chemical binding]; other site 930170000351 Walker B motif; other site 930170000352 arginine finger; other site 930170000353 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 930170000354 hypothetical protein; Validated; Region: PRK00153 930170000355 recombination protein RecR; Reviewed; Region: recR; PRK00076 930170000356 RecR protein; Region: RecR; pfam02132 930170000357 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 930170000358 putative active site [active] 930170000359 putative metal-binding site [ion binding]; other site 930170000360 tetramer interface [polypeptide binding]; other site 930170000361 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 930170000362 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 930170000363 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 930170000364 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 930170000365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930170000366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170000367 catalytic residue [active] 930170000368 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 930170000369 thymidylate kinase; Validated; Region: tmk; PRK00698 930170000370 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 930170000371 TMP-binding site; other site 930170000372 ATP-binding site [chemical binding]; other site 930170000373 DNA polymerase III subunit delta'; Validated; Region: PRK08058 930170000374 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 930170000375 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 930170000376 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 930170000377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170000378 S-adenosylmethionine binding site [chemical binding]; other site 930170000379 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 930170000380 GIY-YIG motif/motif A; other site 930170000381 putative active site [active] 930170000382 putative metal binding site [ion binding]; other site 930170000383 Predicted methyltransferases [General function prediction only]; Region: COG0313 930170000384 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 930170000385 putative SAM binding site [chemical binding]; other site 930170000386 putative homodimer interface [polypeptide binding]; other site 930170000387 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 930170000388 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930170000389 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 930170000390 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 930170000391 active site 930170000392 HIGH motif; other site 930170000393 KMSKS motif; other site 930170000394 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 930170000395 tRNA binding surface [nucleotide binding]; other site 930170000396 anticodon binding site; other site 930170000397 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 930170000398 dimer interface [polypeptide binding]; other site 930170000399 putative tRNA-binding site [nucleotide binding]; other site 930170000400 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 930170000401 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 930170000402 active site 930170000403 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 930170000404 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 930170000405 putative active site [active] 930170000406 putative metal binding site [ion binding]; other site 930170000407 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 930170000408 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 930170000409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170000410 S-adenosylmethionine binding site [chemical binding]; other site 930170000411 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 930170000412 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 930170000413 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170000414 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 930170000415 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930170000416 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930170000417 pur operon repressor; Provisional; Region: PRK09213 930170000418 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 930170000419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170000420 active site 930170000421 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 930170000422 homotrimer interaction site [polypeptide binding]; other site 930170000423 putative active site [active] 930170000424 regulatory protein SpoVG; Reviewed; Region: PRK13259 930170000425 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 930170000426 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 930170000427 Substrate binding site; other site 930170000428 Mg++ binding site; other site 930170000429 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 930170000430 active site 930170000431 substrate binding site [chemical binding]; other site 930170000432 CoA binding site [chemical binding]; other site 930170000433 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 930170000434 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 930170000435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170000436 active site 930170000437 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 930170000438 putative active site [active] 930170000439 catalytic residue [active] 930170000440 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 930170000441 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 930170000442 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 930170000443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170000444 ATP binding site [chemical binding]; other site 930170000445 putative Mg++ binding site [ion binding]; other site 930170000446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170000447 nucleotide binding region [chemical binding]; other site 930170000448 ATP-binding site [chemical binding]; other site 930170000449 TRCF domain; Region: TRCF; pfam03461 930170000450 stage V sporulation protein T; Region: spore_V_T; TIGR02851 930170000451 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 930170000452 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930170000453 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 930170000454 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 930170000455 putative SAM binding site [chemical binding]; other site 930170000456 putative homodimer interface [polypeptide binding]; other site 930170000457 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 930170000458 homodimer interface [polypeptide binding]; other site 930170000459 metal binding site [ion binding]; metal-binding site 930170000460 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 930170000461 homodimer interface [polypeptide binding]; other site 930170000462 active site 930170000463 putative chemical substrate binding site [chemical binding]; other site 930170000464 metal binding site [ion binding]; metal-binding site 930170000465 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170000466 RNA binding surface [nucleotide binding]; other site 930170000467 sporulation protein YabP; Region: spore_yabP; TIGR02892 930170000468 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 930170000469 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 930170000470 Septum formation initiator; Region: DivIC; pfam04977 930170000471 hypothetical protein; Provisional; Region: PRK08582 930170000472 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930170000473 RNA binding site [nucleotide binding]; other site 930170000474 stage II sporulation protein E; Region: spore_II_E; TIGR02865 930170000475 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 930170000476 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 930170000477 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 930170000478 Ligand Binding Site [chemical binding]; other site 930170000479 TilS substrate binding domain; Region: TilS; pfam09179 930170000480 TilS substrate C-terminal domain; Region: TilS_C; smart00977 930170000481 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170000482 active site 930170000483 FtsH Extracellular; Region: FtsH_ext; pfam06480 930170000484 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 930170000485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170000486 Walker A motif; other site 930170000487 ATP binding site [chemical binding]; other site 930170000488 Walker B motif; other site 930170000489 arginine finger; other site 930170000490 Peptidase family M41; Region: Peptidase_M41; pfam01434 930170000491 pantothenate kinase; Reviewed; Region: PRK13318 930170000492 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 930170000493 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 930170000494 dimerization interface [polypeptide binding]; other site 930170000495 domain crossover interface; other site 930170000496 redox-dependent activation switch; other site 930170000497 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930170000498 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930170000499 dimer interface [polypeptide binding]; other site 930170000500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170000501 catalytic residue [active] 930170000502 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 930170000503 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 930170000504 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930170000505 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 930170000506 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930170000507 glutamine binding [chemical binding]; other site 930170000508 catalytic triad [active] 930170000509 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930170000510 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 930170000511 homodimer interface [polypeptide binding]; other site 930170000512 substrate-cofactor binding pocket; other site 930170000513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170000514 catalytic residue [active] 930170000515 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 930170000516 dihydropteroate synthase; Region: DHPS; TIGR01496 930170000517 substrate binding pocket [chemical binding]; other site 930170000518 dimer interface [polypeptide binding]; other site 930170000519 inhibitor binding site; inhibition site 930170000520 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 930170000521 homooctamer interface [polypeptide binding]; other site 930170000522 active site 930170000523 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 930170000524 catalytic center binding site [active] 930170000525 ATP binding site [chemical binding]; other site 930170000526 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170000527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170000528 non-specific DNA binding site [nucleotide binding]; other site 930170000529 salt bridge; other site 930170000530 sequence-specific DNA binding site [nucleotide binding]; other site 930170000531 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 930170000532 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 930170000533 FMN binding site [chemical binding]; other site 930170000534 active site 930170000535 catalytic residues [active] 930170000536 substrate binding site [chemical binding]; other site 930170000537 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 930170000538 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 930170000539 dimer interface [polypeptide binding]; other site 930170000540 putative anticodon binding site; other site 930170000541 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 930170000542 motif 1; other site 930170000543 active site 930170000544 motif 2; other site 930170000545 motif 3; other site 930170000546 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 930170000547 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 930170000548 UvrB/uvrC motif; Region: UVR; pfam02151 930170000549 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 930170000550 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 930170000551 ADP binding site [chemical binding]; other site 930170000552 phosphagen binding site; other site 930170000553 substrate specificity loop; other site 930170000554 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 930170000555 Clp amino terminal domain; Region: Clp_N; pfam02861 930170000556 Clp amino terminal domain; Region: Clp_N; pfam02861 930170000557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170000558 Walker A motif; other site 930170000559 ATP binding site [chemical binding]; other site 930170000560 Walker B motif; other site 930170000561 arginine finger; other site 930170000562 UvrB/uvrC motif; Region: UVR; pfam02151 930170000563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170000564 Walker A motif; other site 930170000565 ATP binding site [chemical binding]; other site 930170000566 Walker B motif; other site 930170000567 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930170000568 DNA repair protein RadA; Provisional; Region: PRK11823 930170000569 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 930170000570 Walker A motif/ATP binding site; other site 930170000571 ATP binding site [chemical binding]; other site 930170000572 Walker B motif; other site 930170000573 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 930170000574 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 930170000575 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 930170000576 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 930170000577 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 930170000578 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 930170000579 putative active site [active] 930170000580 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 930170000581 substrate binding site; other site 930170000582 dimer interface; other site 930170000583 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 930170000584 homotrimer interaction site [polypeptide binding]; other site 930170000585 zinc binding site [ion binding]; other site 930170000586 CDP-binding sites; other site 930170000587 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 930170000588 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930170000589 active site 930170000590 HIGH motif; other site 930170000591 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930170000592 active site 930170000593 KMSKS motif; other site 930170000594 serine O-acetyltransferase; Region: cysE; TIGR01172 930170000595 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 930170000596 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 930170000597 trimer interface [polypeptide binding]; other site 930170000598 active site 930170000599 substrate binding site [chemical binding]; other site 930170000600 CoA binding site [chemical binding]; other site 930170000601 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 930170000602 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930170000603 active site 930170000604 HIGH motif; other site 930170000605 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930170000606 KMSKS motif; other site 930170000607 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 930170000608 tRNA binding surface [nucleotide binding]; other site 930170000609 anticodon binding site; other site 930170000610 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 930170000611 active site 930170000612 metal binding site [ion binding]; metal-binding site 930170000613 dimerization interface [polypeptide binding]; other site 930170000614 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 930170000615 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 930170000616 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930170000617 YacP-like NYN domain; Region: NYN_YacP; pfam05991 930170000618 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 930170000619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170000620 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 930170000621 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 930170000622 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 930170000623 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 930170000624 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 930170000625 putative homodimer interface [polypeptide binding]; other site 930170000626 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 930170000627 heterodimer interface [polypeptide binding]; other site 930170000628 homodimer interface [polypeptide binding]; other site 930170000629 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 930170000630 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 930170000631 23S rRNA interface [nucleotide binding]; other site 930170000632 L7/L12 interface [polypeptide binding]; other site 930170000633 putative thiostrepton binding site; other site 930170000634 L25 interface [polypeptide binding]; other site 930170000635 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 930170000636 mRNA/rRNA interface [nucleotide binding]; other site 930170000637 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 930170000638 23S rRNA interface [nucleotide binding]; other site 930170000639 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 930170000640 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 930170000641 core dimer interface [polypeptide binding]; other site 930170000642 peripheral dimer interface [polypeptide binding]; other site 930170000643 L10 interface [polypeptide binding]; other site 930170000644 L11 interface [polypeptide binding]; other site 930170000645 putative EF-Tu interaction site [polypeptide binding]; other site 930170000646 putative EF-G interaction site [polypeptide binding]; other site 930170000647 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 930170000648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170000649 S-adenosylmethionine binding site [chemical binding]; other site 930170000650 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 930170000651 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930170000652 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 930170000653 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930170000654 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 930170000655 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930170000656 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 930170000657 RPB10 interaction site [polypeptide binding]; other site 930170000658 RPB1 interaction site [polypeptide binding]; other site 930170000659 RPB11 interaction site [polypeptide binding]; other site 930170000660 RPB3 interaction site [polypeptide binding]; other site 930170000661 RPB12 interaction site [polypeptide binding]; other site 930170000662 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 930170000663 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 930170000664 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 930170000665 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 930170000666 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 930170000667 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 930170000668 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 930170000669 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 930170000670 G-loop; other site 930170000671 DNA binding site [nucleotide binding] 930170000672 hypothetical protein; Provisional; Region: PRK06683 930170000673 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 930170000674 S17 interaction site [polypeptide binding]; other site 930170000675 S8 interaction site; other site 930170000676 16S rRNA interaction site [nucleotide binding]; other site 930170000677 streptomycin interaction site [chemical binding]; other site 930170000678 23S rRNA interaction site [nucleotide binding]; other site 930170000679 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 930170000680 30S ribosomal protein S7; Validated; Region: PRK05302 930170000681 elongation factor G; Reviewed; Region: PRK00007 930170000682 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 930170000683 G1 box; other site 930170000684 putative GEF interaction site [polypeptide binding]; other site 930170000685 GTP/Mg2+ binding site [chemical binding]; other site 930170000686 Switch I region; other site 930170000687 G2 box; other site 930170000688 G3 box; other site 930170000689 Switch II region; other site 930170000690 G4 box; other site 930170000691 G5 box; other site 930170000692 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 930170000693 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 930170000694 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 930170000695 elongation factor Tu; Reviewed; Region: PRK00049 930170000696 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 930170000697 G1 box; other site 930170000698 GEF interaction site [polypeptide binding]; other site 930170000699 GTP/Mg2+ binding site [chemical binding]; other site 930170000700 Switch I region; other site 930170000701 G2 box; other site 930170000702 G3 box; other site 930170000703 Switch II region; other site 930170000704 G4 box; other site 930170000705 G5 box; other site 930170000706 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 930170000707 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 930170000708 Antibiotic Binding Site [chemical binding]; other site 930170000709 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 930170000710 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 930170000711 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 930170000712 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 930170000713 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 930170000714 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 930170000715 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 930170000716 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 930170000717 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 930170000718 putative translocon binding site; other site 930170000719 protein-rRNA interface [nucleotide binding]; other site 930170000720 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 930170000721 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 930170000722 G-X-X-G motif; other site 930170000723 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 930170000724 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 930170000725 23S rRNA interface [nucleotide binding]; other site 930170000726 5S rRNA interface [nucleotide binding]; other site 930170000727 putative antibiotic binding site [chemical binding]; other site 930170000728 L25 interface [polypeptide binding]; other site 930170000729 L27 interface [polypeptide binding]; other site 930170000730 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 930170000731 23S rRNA interface [nucleotide binding]; other site 930170000732 putative translocon interaction site; other site 930170000733 signal recognition particle (SRP54) interaction site; other site 930170000734 L23 interface [polypeptide binding]; other site 930170000735 trigger factor interaction site; other site 930170000736 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 930170000737 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 930170000738 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 930170000739 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 930170000740 RNA binding site [nucleotide binding]; other site 930170000741 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 930170000742 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 930170000743 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 930170000744 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 930170000745 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 930170000746 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 930170000747 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930170000748 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930170000749 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 930170000750 5S rRNA interface [nucleotide binding]; other site 930170000751 L27 interface [polypeptide binding]; other site 930170000752 23S rRNA interface [nucleotide binding]; other site 930170000753 L5 interface [polypeptide binding]; other site 930170000754 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 930170000755 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 930170000756 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 930170000757 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 930170000758 23S rRNA binding site [nucleotide binding]; other site 930170000759 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 930170000760 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 930170000761 SecY translocase; Region: SecY; pfam00344 930170000762 adenylate kinase; Reviewed; Region: adk; PRK00279 930170000763 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 930170000764 AMP-binding site [chemical binding]; other site 930170000765 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 930170000766 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930170000767 active site 930170000768 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 930170000769 rRNA binding site [nucleotide binding]; other site 930170000770 predicted 30S ribosome binding site; other site 930170000771 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 930170000772 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 930170000773 30S ribosomal protein S13; Region: bact_S13; TIGR03631 930170000774 30S ribosomal protein S11; Validated; Region: PRK05309 930170000775 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 930170000776 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 930170000777 alphaNTD - beta interaction site [polypeptide binding]; other site 930170000778 alphaNTD homodimer interface [polypeptide binding]; other site 930170000779 alphaNTD - beta' interaction site [polypeptide binding]; other site 930170000780 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 930170000781 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 930170000782 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 930170000783 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930170000784 Walker A/P-loop; other site 930170000785 ATP binding site [chemical binding]; other site 930170000786 Q-loop/lid; other site 930170000787 ABC transporter signature motif; other site 930170000788 Walker B; other site 930170000789 D-loop; other site 930170000790 H-loop/switch region; other site 930170000791 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 930170000792 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930170000793 Walker A/P-loop; other site 930170000794 ATP binding site [chemical binding]; other site 930170000795 Q-loop/lid; other site 930170000796 ABC transporter signature motif; other site 930170000797 Walker B; other site 930170000798 D-loop; other site 930170000799 H-loop/switch region; other site 930170000800 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930170000801 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 930170000802 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 930170000803 dimerization interface 3.5A [polypeptide binding]; other site 930170000804 active site 930170000805 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 930170000806 23S rRNA interface [nucleotide binding]; other site 930170000807 L3 interface [polypeptide binding]; other site 930170000808 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 930170000809 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 930170000810 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930170000811 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930170000812 active site 930170000813 metal binding site [ion binding]; metal-binding site 930170000814 Domain of unknown function DUF59; Region: DUF59; pfam01883 930170000815 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 930170000816 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 930170000817 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 930170000818 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170000819 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 930170000820 NodB motif; other site 930170000821 putative active site [active] 930170000822 putative catalytic site [active] 930170000823 potential protein location (hypothetical protein YBT020_00750 [Bacillus thuringiensis YBT-020]) that overlaps RNA (tRNA-E) 930170000824 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 930170000825 Arginase family; Region: Arginase; cd09989 930170000826 agmatinase; Region: agmatinase; TIGR01230 930170000827 active site 930170000828 Mn binding site [ion binding]; other site 930170000829 oligomer interface [polypeptide binding]; other site 930170000830 Uncharacterized conserved protein [Function unknown]; Region: COG1624 930170000831 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 930170000832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 930170000833 YbbR-like protein; Region: YbbR; pfam07949 930170000834 YbbR-like protein; Region: YbbR; pfam07949 930170000835 YbbR-like protein; Region: YbbR; pfam07949 930170000836 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 930170000837 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 930170000838 active site 930170000839 substrate binding site [chemical binding]; other site 930170000840 metal binding site [ion binding]; metal-binding site 930170000841 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 930170000842 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 930170000843 glutaminase active site [active] 930170000844 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930170000845 dimer interface [polypeptide binding]; other site 930170000846 active site 930170000847 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930170000848 dimer interface [polypeptide binding]; other site 930170000849 active site 930170000850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170000851 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930170000852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170000853 DNA-binding site [nucleotide binding]; DNA binding site 930170000854 FCD domain; Region: FCD; pfam07729 930170000855 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 930170000856 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 930170000857 N- and C-terminal domain interface [polypeptide binding]; other site 930170000858 active site 930170000859 catalytic site [active] 930170000860 metal binding site [ion binding]; metal-binding site 930170000861 carbohydrate binding site [chemical binding]; other site 930170000862 ATP binding site [chemical binding]; other site 930170000863 fructuronate transporter; Provisional; Region: PRK10034; cl15264 930170000864 gluconate transporter; Region: gntP; TIGR00791 930170000865 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930170000866 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 930170000867 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 930170000868 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 930170000869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930170000870 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 930170000871 DoxX; Region: DoxX; cl17842 930170000872 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 930170000873 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 930170000874 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 930170000875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170000876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170000877 DNA binding residues [nucleotide binding] 930170000878 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 930170000879 classical (c) SDRs; Region: SDR_c; cd05233 930170000880 NAD(P) binding site [chemical binding]; other site 930170000881 active site 930170000882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170000883 ABC-ATPase subunit interface; other site 930170000884 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 930170000885 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930170000886 Walker A/P-loop; other site 930170000887 ATP binding site [chemical binding]; other site 930170000888 Q-loop/lid; other site 930170000889 ABC transporter signature motif; other site 930170000890 Walker B; other site 930170000891 D-loop; other site 930170000892 H-loop/switch region; other site 930170000893 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930170000894 NIL domain; Region: NIL; pfam09383 930170000895 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930170000896 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930170000897 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930170000898 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 930170000899 putative NAD(P) binding site [chemical binding]; other site 930170000900 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 930170000901 FAD binding domain; Region: FAD_binding_4; pfam01565 930170000902 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 930170000903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170000905 putative substrate translocation pore; other site 930170000906 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 930170000907 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 930170000908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170000909 putative substrate translocation pore; other site 930170000910 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 930170000911 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 930170000912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170000913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170000914 dimer interface [polypeptide binding]; other site 930170000915 conserved gate region; other site 930170000916 putative PBP binding loops; other site 930170000917 ABC-ATPase subunit interface; other site 930170000918 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170000919 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930170000920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170000921 dimer interface [polypeptide binding]; other site 930170000922 conserved gate region; other site 930170000923 putative PBP binding loops; other site 930170000924 ABC-ATPase subunit interface; other site 930170000925 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930170000926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170000927 Walker A/P-loop; other site 930170000928 ATP binding site [chemical binding]; other site 930170000929 Q-loop/lid; other site 930170000930 ABC transporter signature motif; other site 930170000931 Walker B; other site 930170000932 D-loop; other site 930170000933 H-loop/switch region; other site 930170000934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930170000935 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930170000936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170000937 Walker A/P-loop; other site 930170000938 ATP binding site [chemical binding]; other site 930170000939 Q-loop/lid; other site 930170000940 ABC transporter signature motif; other site 930170000941 Walker B; other site 930170000942 D-loop; other site 930170000943 H-loop/switch region; other site 930170000944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 930170000945 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170000946 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170000947 peptide binding site [polypeptide binding]; other site 930170000948 YusW-like protein; Region: YusW; pfam14039 930170000949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170000950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170000951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170000952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170000953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170000954 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930170000955 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930170000956 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170000957 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170000958 peptide binding site [polypeptide binding]; other site 930170000959 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170000960 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170000961 peptide binding site [polypeptide binding]; other site 930170000962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930170000963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930170000964 active site 930170000965 catalytic tetrad [active] 930170000966 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 930170000967 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 930170000968 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 930170000969 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930170000970 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 930170000971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170000972 dimer interface [polypeptide binding]; other site 930170000973 conserved gate region; other site 930170000974 putative PBP binding loops; other site 930170000975 ABC-ATPase subunit interface; other site 930170000976 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 930170000977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930170000978 dimerization interface [polypeptide binding]; other site 930170000979 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170000980 membrane-bound complex binding site; other site 930170000981 hinge residues; other site 930170000982 DNA binding domain, excisionase family; Region: excise; TIGR01764 930170000983 PBP superfamily domain; Region: PBP_like; pfam12727 930170000984 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170000985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170000986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170000987 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 930170000988 putative dimerization interface [polypeptide binding]; other site 930170000989 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170000990 EamA-like transporter family; Region: EamA; pfam00892 930170000991 YrzO-like protein; Region: YrzO; pfam14142 930170000992 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930170000993 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930170000994 putative acyl-acceptor binding pocket; other site 930170000995 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170000996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170000997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170000998 DNA binding site [nucleotide binding] 930170000999 domain linker motif; other site 930170001000 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930170001001 putative ligand binding site [chemical binding]; other site 930170001002 putative dimerization interface [polypeptide binding]; other site 930170001003 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170001004 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170001005 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170001006 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170001007 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 930170001008 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 930170001009 active site 930170001010 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 930170001011 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 930170001012 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 930170001013 lysozyme catalytic site [active] 930170001014 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 930170001015 nucleotide binding site/active site [active] 930170001016 HIT family signature motif; other site 930170001017 catalytic residue [active] 930170001018 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170001019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001021 ABC transporter; Region: ABC_tran_2; pfam12848 930170001022 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170001024 Histidine kinase; Region: HisKA_3; pfam07730 930170001025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170001026 ATP binding site [chemical binding]; other site 930170001027 Mg2+ binding site [ion binding]; other site 930170001028 G-X-G motif; other site 930170001029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170001031 active site 930170001032 phosphorylation site [posttranslational modification] 930170001033 intermolecular recognition site; other site 930170001034 dimerization interface [polypeptide binding]; other site 930170001035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170001036 DNA binding residues [nucleotide binding] 930170001037 dimerization interface [polypeptide binding]; other site 930170001038 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170001039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170001040 Walker A/P-loop; other site 930170001041 ATP binding site [chemical binding]; other site 930170001042 Q-loop/lid; other site 930170001043 ABC transporter signature motif; other site 930170001044 Walker B; other site 930170001045 D-loop; other site 930170001046 H-loop/switch region; other site 930170001047 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 930170001048 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930170001049 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930170001050 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930170001051 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930170001052 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930170001053 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930170001054 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930170001055 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 930170001056 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170001057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170001058 dimer interface [polypeptide binding]; other site 930170001059 conserved gate region; other site 930170001060 putative PBP binding loops; other site 930170001061 ABC-ATPase subunit interface; other site 930170001062 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170001063 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930170001064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170001065 dimer interface [polypeptide binding]; other site 930170001066 conserved gate region; other site 930170001067 putative PBP binding loops; other site 930170001068 ABC-ATPase subunit interface; other site 930170001069 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930170001070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170001071 Walker A/P-loop; other site 930170001072 ATP binding site [chemical binding]; other site 930170001073 Q-loop/lid; other site 930170001074 ABC transporter signature motif; other site 930170001075 Walker B; other site 930170001076 D-loop; other site 930170001077 H-loop/switch region; other site 930170001078 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 930170001079 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 930170001080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170001081 Walker A/P-loop; other site 930170001082 ATP binding site [chemical binding]; other site 930170001083 Q-loop/lid; other site 930170001084 ABC transporter signature motif; other site 930170001085 Walker B; other site 930170001086 D-loop; other site 930170001087 H-loop/switch region; other site 930170001088 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 930170001089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170001090 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170001091 active site 930170001092 motif I; other site 930170001093 motif II; other site 930170001094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170001095 motif II; other site 930170001096 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001097 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001098 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001099 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001100 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001101 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001102 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001103 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 930170001104 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 930170001105 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 930170001106 dimer interface [polypeptide binding]; other site 930170001107 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 930170001108 active site 930170001109 Fe binding site [ion binding]; other site 930170001110 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930170001111 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930170001112 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 930170001113 amino acid transporter; Region: 2A0306; TIGR00909 930170001114 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930170001115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170001116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170001117 putative substrate translocation pore; other site 930170001118 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 930170001119 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 930170001120 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 930170001121 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 930170001122 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930170001123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930170001124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930170001125 helicase 45; Provisional; Region: PTZ00424 930170001126 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930170001127 ATP binding site [chemical binding]; other site 930170001128 Mg++ binding site [ion binding]; other site 930170001129 motif III; other site 930170001130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170001131 nucleotide binding region [chemical binding]; other site 930170001132 ATP-binding site [chemical binding]; other site 930170001133 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 930170001134 Rhomboid family; Region: Rhomboid; pfam01694 930170001135 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 930170001136 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 930170001137 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 930170001138 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 930170001139 alanine racemase; Reviewed; Region: alr; PRK00053 930170001140 active site 930170001141 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930170001142 dimer interface [polypeptide binding]; other site 930170001143 substrate binding site [chemical binding]; other site 930170001144 catalytic residues [active] 930170001145 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 930170001146 PemK-like protein; Region: PemK; pfam02452 930170001147 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 930170001148 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 930170001149 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 930170001150 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 930170001151 RNA binding site [nucleotide binding]; other site 930170001152 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170001153 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170001154 putative active site [active] 930170001155 putative NTP binding site [chemical binding]; other site 930170001156 putative nucleic acid binding site [nucleotide binding]; other site 930170001157 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170001158 SprT homologues; Region: SprT; cl01182 930170001159 SprT-like family; Region: SprT-like; pfam10263 930170001160 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 930170001161 Glycoprotease family; Region: Peptidase_M22; pfam00814 930170001162 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930170001163 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 930170001164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170001165 Coenzyme A binding pocket [chemical binding]; other site 930170001166 UGMP family protein; Validated; Region: PRK09604 930170001167 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930170001168 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930170001169 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170001170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001172 ABC transporter; Region: ABC_tran_2; pfam12848 930170001173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001174 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 930170001175 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 930170001176 CoA binding domain; Region: CoA_binding; pfam02629 930170001177 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 930170001178 CAAX protease self-immunity; Region: Abi; pfam02517 930170001179 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 930170001180 oligomerisation interface [polypeptide binding]; other site 930170001181 mobile loop; other site 930170001182 roof hairpin; other site 930170001183 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 930170001184 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 930170001185 ring oligomerisation interface [polypeptide binding]; other site 930170001186 ATP/Mg binding site [chemical binding]; other site 930170001187 stacking interactions; other site 930170001188 hinge regions; other site 930170001189 Uncharacterized conserved protein [Function unknown]; Region: COG5444 930170001190 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930170001191 GMP synthase; Reviewed; Region: guaA; PRK00074 930170001192 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 930170001193 AMP/PPi binding site [chemical binding]; other site 930170001194 candidate oxyanion hole; other site 930170001195 catalytic triad [active] 930170001196 potential glutamine specificity residues [chemical binding]; other site 930170001197 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 930170001198 ATP Binding subdomain [chemical binding]; other site 930170001199 Ligand Binding sites [chemical binding]; other site 930170001200 Dimerization subdomain; other site 930170001201 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930170001202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170001203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170001204 active site 930170001205 phosphorylation site [posttranslational modification] 930170001206 intermolecular recognition site; other site 930170001207 dimerization interface [polypeptide binding]; other site 930170001208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170001209 DNA binding site [nucleotide binding] 930170001210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170001211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170001212 dimerization interface [polypeptide binding]; other site 930170001213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170001214 dimer interface [polypeptide binding]; other site 930170001215 phosphorylation site [posttranslational modification] 930170001216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170001217 ATP binding site [chemical binding]; other site 930170001218 Mg2+ binding site [ion binding]; other site 930170001219 G-X-G motif; other site 930170001220 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930170001221 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930170001222 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930170001223 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 930170001224 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 930170001225 catalytic residues [active] 930170001226 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 930170001227 putative ligand binding site [chemical binding]; other site 930170001228 putative catalytic site [active] 930170001229 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170001230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170001231 S-adenosylmethionine binding site [chemical binding]; other site 930170001232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170001233 S-adenosylmethionine binding site [chemical binding]; other site 930170001234 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 930170001235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930170001236 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 930170001237 putative NAD(P) binding site [chemical binding]; other site 930170001238 active site 930170001239 putative substrate binding site [chemical binding]; other site 930170001240 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170001241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170001242 S-adenosylmethionine binding site [chemical binding]; other site 930170001243 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 930170001244 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930170001245 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170001246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170001247 active site 930170001248 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170001249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170001250 DNA-binding site [nucleotide binding]; DNA binding site 930170001251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170001252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170001253 homodimer interface [polypeptide binding]; other site 930170001254 catalytic residue [active] 930170001255 Proline dehydrogenase; Region: Pro_dh; cl03282 930170001256 EamA-like transporter family; Region: EamA; pfam00892 930170001257 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170001258 EamA-like transporter family; Region: EamA; pfam00892 930170001259 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 930170001260 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 930170001261 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 930170001262 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 930170001263 NAD binding site [chemical binding]; other site 930170001264 ATP-grasp domain; Region: ATP-grasp; pfam02222 930170001265 adenylosuccinate lyase; Provisional; Region: PRK07492 930170001266 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 930170001267 tetramer interface [polypeptide binding]; other site 930170001268 active site 930170001269 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 930170001270 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 930170001271 ATP binding site [chemical binding]; other site 930170001272 active site 930170001273 substrate binding site [chemical binding]; other site 930170001274 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 930170001275 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 930170001276 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 930170001277 putative active site [active] 930170001278 catalytic triad [active] 930170001279 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 930170001280 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 930170001281 dimerization interface [polypeptide binding]; other site 930170001282 ATP binding site [chemical binding]; other site 930170001283 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 930170001284 dimerization interface [polypeptide binding]; other site 930170001285 ATP binding site [chemical binding]; other site 930170001286 amidophosphoribosyltransferase; Provisional; Region: PRK06781 930170001287 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 930170001288 active site 930170001289 tetramer interface [polypeptide binding]; other site 930170001290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170001291 active site 930170001292 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 930170001293 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 930170001294 dimerization interface [polypeptide binding]; other site 930170001295 putative ATP binding site [chemical binding]; other site 930170001296 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 930170001297 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 930170001298 active site 930170001299 substrate binding site [chemical binding]; other site 930170001300 cosubstrate binding site; other site 930170001301 catalytic site [active] 930170001302 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 930170001303 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 930170001304 purine monophosphate binding site [chemical binding]; other site 930170001305 dimer interface [polypeptide binding]; other site 930170001306 putative catalytic residues [active] 930170001307 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 930170001308 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 930170001309 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 930170001310 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 930170001311 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 930170001312 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 930170001313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 930170001314 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 930170001315 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 930170001316 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 930170001317 PcrB family; Region: PcrB; pfam01884 930170001318 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 930170001319 substrate binding site [chemical binding]; other site 930170001320 putative active site [active] 930170001321 dimer interface [polypeptide binding]; other site 930170001322 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 930170001323 Part of AAA domain; Region: AAA_19; pfam13245 930170001324 Family description; Region: UvrD_C_2; pfam13538 930170001325 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 930170001326 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 930170001327 nucleotide binding pocket [chemical binding]; other site 930170001328 K-X-D-G motif; other site 930170001329 catalytic site [active] 930170001330 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 930170001331 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 930170001332 Dimer interface [polypeptide binding]; other site 930170001333 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 930170001334 putative dimer interface [polypeptide binding]; other site 930170001335 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 930170001336 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 930170001337 putative dimer interface [polypeptide binding]; other site 930170001338 hypothetical protein; Provisional; Region: PRK10621 930170001339 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170001340 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 930170001341 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 930170001342 Glutamate binding site [chemical binding]; other site 930170001343 homodimer interface [polypeptide binding]; other site 930170001344 NAD binding site [chemical binding]; other site 930170001345 catalytic residues [active] 930170001346 Isochorismatase family; Region: Isochorismatase; pfam00857 930170001347 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 930170001348 catalytic triad [active] 930170001349 conserved cis-peptide bond; other site 930170001350 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 930170001351 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930170001352 Walker A/P-loop; other site 930170001353 ATP binding site [chemical binding]; other site 930170001354 Q-loop/lid; other site 930170001355 ABC transporter signature motif; other site 930170001356 Walker B; other site 930170001357 D-loop; other site 930170001358 H-loop/switch region; other site 930170001359 NIL domain; Region: NIL; pfam09383 930170001360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170001361 dimer interface [polypeptide binding]; other site 930170001362 conserved gate region; other site 930170001363 ABC-ATPase subunit interface; other site 930170001364 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930170001365 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930170001366 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 930170001367 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 930170001368 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 930170001369 P loop; other site 930170001370 Nucleotide binding site [chemical binding]; other site 930170001371 DTAP/Switch II; other site 930170001372 Switch I; other site 930170001373 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 930170001374 putative dimer interface [polypeptide binding]; other site 930170001375 MarR family; Region: MarR_2; cl17246 930170001376 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930170001377 MULE transposase domain; Region: MULE; pfam10551 930170001378 yiaA/B two helix domain; Region: YiaAB; pfam05360 930170001379 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 930170001380 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930170001381 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 930170001382 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 930170001383 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 930170001384 GatB domain; Region: GatB_Yqey; pfam02637 930170001385 putative lipid kinase; Reviewed; Region: PRK13337 930170001386 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930170001387 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170001388 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170001389 putative active site [active] 930170001390 putative NTP binding site [chemical binding]; other site 930170001391 putative nucleic acid binding site [nucleotide binding]; other site 930170001392 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170001393 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930170001394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170001395 motif II; other site 930170001396 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 930170001397 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170001398 inhibitor-cofactor binding pocket; inhibition site 930170001399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170001400 catalytic residue [active] 930170001401 PAS domain; Region: PAS_9; pfam13426 930170001402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170001403 putative active site [active] 930170001404 heme pocket [chemical binding]; other site 930170001405 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 930170001406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170001407 Walker A motif; other site 930170001408 ATP binding site [chemical binding]; other site 930170001409 Walker B motif; other site 930170001410 arginine finger; other site 930170001411 succinic semialdehyde dehydrogenase; Region: PLN02278 930170001412 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 930170001413 tetramerization interface [polypeptide binding]; other site 930170001414 NAD(P) binding site [chemical binding]; other site 930170001415 catalytic residues [active] 930170001416 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170001417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001418 non-specific DNA binding site [nucleotide binding]; other site 930170001419 salt bridge; other site 930170001420 sequence-specific DNA binding site [nucleotide binding]; other site 930170001421 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930170001422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 930170001423 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930170001424 putative FMN binding site [chemical binding]; other site 930170001425 NADPH bind site [chemical binding]; other site 930170001426 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930170001427 putative FMN binding site [chemical binding]; other site 930170001428 NADPH bind site [chemical binding]; other site 930170001429 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930170001430 putative FMN binding site [chemical binding]; other site 930170001431 NADPH bind site [chemical binding]; other site 930170001432 YcaO-like family; Region: YcaO; pfam02624 930170001433 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930170001434 NADPH bind site [chemical binding]; other site 930170001435 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170001436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170001437 putative substrate translocation pore; other site 930170001438 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 930170001439 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 930170001440 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170001441 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 930170001442 putative active site [active] 930170001443 putative metal binding site [ion binding]; other site 930170001444 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170001445 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170001446 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170001447 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 930170001448 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 930170001449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170001450 S-adenosylmethionine binding site [chemical binding]; other site 930170001451 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 930170001452 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930170001453 Int/Topo IB signature motif; other site 930170001454 Short C-terminal domain; Region: SHOCT; pfam09851 930170001455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001456 non-specific DNA binding site [nucleotide binding]; other site 930170001457 salt bridge; other site 930170001458 sequence-specific DNA binding site [nucleotide binding]; other site 930170001459 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170001460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001461 non-specific DNA binding site [nucleotide binding]; other site 930170001462 salt bridge; other site 930170001463 sequence-specific DNA binding site [nucleotide binding]; other site 930170001464 dsDNA Poxvirus; Region: Poxvirus; cl17197 930170001465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170001466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001467 non-specific DNA binding site [nucleotide binding]; other site 930170001468 salt bridge; other site 930170001469 sequence-specific DNA binding site [nucleotide binding]; other site 930170001470 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 930170001471 ORF6C domain; Region: ORF6C; pfam10552 930170001472 Helix-turn-helix domain; Region: HTH_17; pfam12728 930170001473 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 930170001474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930170001475 Walker A motif; other site 930170001476 ATP binding site [chemical binding]; other site 930170001477 Walker B motif; other site 930170001478 arginine finger; other site 930170001479 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 930170001480 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930170001481 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 930170001482 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 930170001483 putative metal binding site [ion binding]; other site 930170001484 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 930170001485 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 930170001486 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 930170001487 Int/Topo IB signature motif; other site 930170001488 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 930170001489 HNH endonuclease; Region: HNH; pfam01844 930170001490 active site 930170001491 Phage terminase, small subunit; Region: Terminase_4; cl01525 930170001492 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 930170001493 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 930170001494 Phage-related protein [Function unknown]; Region: COG4695; cl01923 930170001495 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 930170001496 oligomer interface [polypeptide binding]; other site 930170001497 active site residues [active] 930170001498 Phage capsid family; Region: Phage_capsid; pfam05065 930170001499 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 930170001500 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 930170001501 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 930170001502 Phage-related minor tail protein [Function unknown]; Region: COG5280 930170001503 membrane protein P6; Region: PHA01399 930170001504 membrane protein P6; Region: PHA01399 930170001505 Phage tail protein; Region: Sipho_tail; pfam05709 930170001506 Phage tail protein; Region: Sipho_tail; cl17486 930170001507 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 930170001508 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 930170001509 Haemolysin XhlA; Region: XhlA; pfam10779 930170001510 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170001511 amidase catalytic site [active] 930170001512 Zn binding residues [ion binding]; other site 930170001513 substrate binding site [chemical binding]; other site 930170001514 Bacterial SH3 domain; Region: SH3_3; cl17532 930170001515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170001516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170001517 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 930170001518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001519 non-specific DNA binding site [nucleotide binding]; other site 930170001520 salt bridge; other site 930170001521 sequence-specific DNA binding site [nucleotide binding]; other site 930170001522 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930170001523 Replication-relaxation; Region: Replic_Relax; pfam13814 930170001524 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 930170001525 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 930170001526 FMN binding site [chemical binding]; other site 930170001527 active site 930170001528 catalytic residues [active] 930170001529 substrate binding site [chemical binding]; other site 930170001530 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930170001531 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930170001532 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930170001533 GAF domain; Region: GAF_2; pfam13185 930170001534 PAS domain S-box; Region: sensory_box; TIGR00229 930170001535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170001536 putative active site [active] 930170001537 heme pocket [chemical binding]; other site 930170001538 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170001539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170001540 metal binding site [ion binding]; metal-binding site 930170001541 active site 930170001542 I-site; other site 930170001543 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170001544 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 930170001545 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930170001546 PYR/PP interface [polypeptide binding]; other site 930170001547 dimer interface [polypeptide binding]; other site 930170001548 TPP binding site [chemical binding]; other site 930170001549 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170001550 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 930170001551 TPP-binding site [chemical binding]; other site 930170001552 SEFIR domain; Region: SEFIR; pfam08357 930170001553 potential frameshift: common BLAST hit: gi|152976020|ref|YP_001375537.1| integrase catalytic region 930170001554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 930170001555 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 930170001556 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 930170001557 Protein of unknown function DUF45; Region: DUF45; pfam01863 930170001558 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 930170001559 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 930170001560 active site 930170001561 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 930170001562 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930170001563 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 930170001564 metal binding site [ion binding]; metal-binding site 930170001565 putative dimer interface [polypeptide binding]; other site 930170001566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170001567 S-adenosylmethionine binding site [chemical binding]; other site 930170001568 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 930170001569 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 930170001570 catalytic residue [active] 930170001571 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 930170001572 catalytic residues [active] 930170001573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170001574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170001575 peroxiredoxin; Region: AhpC; TIGR03137 930170001576 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 930170001577 dimer interface [polypeptide binding]; other site 930170001578 decamer (pentamer of dimers) interface [polypeptide binding]; other site 930170001579 catalytic triad [active] 930170001580 peroxidatic and resolving cysteines [active] 930170001581 5-methylribose kinase; Reviewed; Region: PRK12396 930170001582 Phosphotransferase enzyme family; Region: APH; pfam01636 930170001583 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 930170001584 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 930170001585 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 930170001586 intersubunit interface [polypeptide binding]; other site 930170001587 active site 930170001588 Zn2+ binding site [ion binding]; other site 930170001589 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170001590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170001591 ABC-ATPase subunit interface; other site 930170001592 dimer interface [polypeptide binding]; other site 930170001593 putative PBP binding regions; other site 930170001594 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170001595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170001596 ABC-ATPase subunit interface; other site 930170001597 dimer interface [polypeptide binding]; other site 930170001598 putative PBP binding regions; other site 930170001599 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170001600 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 930170001601 putative ligand binding residues [chemical binding]; other site 930170001602 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930170001603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170001604 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 930170001605 Uncharacterized conserved protein [Function unknown]; Region: COG3339 930170001606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 930170001607 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 930170001608 Probable transposase; Region: OrfB_IS605; pfam01385 930170001609 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170001610 DNA binding domain, excisionase family; Region: excise; TIGR01764 930170001611 Sm and related proteins; Region: Sm_like; cl00259 930170001612 Sm1 motif; other site 930170001613 RNA binding site [nucleotide binding]; other site 930170001614 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 930170001615 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 930170001616 hypothetical protein; Provisional; Region: PRK06851 930170001617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930170001618 Walker A motif; other site 930170001619 ATP binding site [chemical binding]; other site 930170001620 NTPase; Region: NTPase_1; cl17478 930170001621 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 930170001622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930170001623 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170001624 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170001625 putative transposase OrfB; Reviewed; Region: PHA02517 930170001626 HTH-like domain; Region: HTH_21; pfam13276 930170001627 Integrase core domain; Region: rve; pfam00665 930170001628 Integrase core domain; Region: rve_2; pfam13333 930170001629 benzoate transport; Region: 2A0115; TIGR00895 930170001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170001631 putative substrate translocation pore; other site 930170001632 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 930170001633 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930170001634 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 930170001635 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 930170001636 [2Fe-2S] cluster binding site [ion binding]; other site 930170001637 Fatty acid desaturase; Region: FA_desaturase; pfam00487 930170001638 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 930170001639 putative di-iron ligands [ion binding]; other site 930170001640 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 930170001641 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 930170001642 DXD motif; other site 930170001643 HEAT repeats; Region: HEAT_2; pfam13646 930170001644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170001646 active site 930170001647 phosphorylation site [posttranslational modification] 930170001648 intermolecular recognition site; other site 930170001649 dimerization interface [polypeptide binding]; other site 930170001650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170001651 dimer interface [polypeptide binding]; other site 930170001652 conserved gate region; other site 930170001653 putative PBP binding loops; other site 930170001654 ABC-ATPase subunit interface; other site 930170001655 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930170001656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170001657 substrate binding pocket [chemical binding]; other site 930170001658 membrane-bound complex binding site; other site 930170001659 hinge residues; other site 930170001660 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930170001661 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930170001662 Walker A/P-loop; other site 930170001663 ATP binding site [chemical binding]; other site 930170001664 Q-loop/lid; other site 930170001665 ABC transporter signature motif; other site 930170001666 Walker B; other site 930170001667 D-loop; other site 930170001668 H-loop/switch region; other site 930170001669 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 930170001670 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930170001671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170001672 dimerization interface [polypeptide binding]; other site 930170001673 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170001674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170001675 dimer interface [polypeptide binding]; other site 930170001676 putative CheW interface [polypeptide binding]; other site 930170001677 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930170001678 HAMP domain; Region: HAMP; pfam00672 930170001679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170001680 dimer interface [polypeptide binding]; other site 930170001681 putative CheW interface [polypeptide binding]; other site 930170001682 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930170001683 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930170001684 Ca binding site [ion binding]; other site 930170001685 active site 930170001686 catalytic site [active] 930170001687 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170001688 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 930170001689 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170001690 active site turn [active] 930170001691 phosphorylation site [posttranslational modification] 930170001692 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 930170001693 putative catalytic site [active] 930170001694 putative metal binding site [ion binding]; other site 930170001695 putative phosphate binding site [ion binding]; other site 930170001696 Predicted membrane protein [Function unknown]; Region: COG1511 930170001697 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930170001698 Predicted membrane protein [Function unknown]; Region: COG1511 930170001699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170001700 DNA topoisomerase III; Provisional; Region: PRK07726 930170001701 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 930170001702 active site 930170001703 putative interdomain interaction site [polypeptide binding]; other site 930170001704 putative metal-binding site [ion binding]; other site 930170001705 putative nucleotide binding site [chemical binding]; other site 930170001706 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930170001707 domain I; other site 930170001708 DNA binding groove [nucleotide binding] 930170001709 phosphate binding site [ion binding]; other site 930170001710 domain II; other site 930170001711 domain III; other site 930170001712 nucleotide binding site [chemical binding]; other site 930170001713 catalytic site [active] 930170001714 domain IV; other site 930170001715 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 930170001716 substrate binding site [chemical binding]; other site 930170001717 multimerization interface [polypeptide binding]; other site 930170001718 ATP binding site [chemical binding]; other site 930170001719 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 930170001720 thiamine phosphate binding site [chemical binding]; other site 930170001721 active site 930170001722 pyrophosphate binding site [ion binding]; other site 930170001723 Predicted esterase [General function prediction only]; Region: COG0400 930170001724 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930170001725 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 930170001726 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 930170001727 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930170001728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170001729 dimerization interface [polypeptide binding]; other site 930170001730 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170001731 dimer interface [polypeptide binding]; other site 930170001732 putative CheW interface [polypeptide binding]; other site 930170001733 Domain of unknown function DUF77; Region: DUF77; pfam01910 930170001734 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930170001735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170001736 dimer interface [polypeptide binding]; other site 930170001737 conserved gate region; other site 930170001738 putative PBP binding loops; other site 930170001739 ABC-ATPase subunit interface; other site 930170001740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 930170001741 NMT1/THI5 like; Region: NMT1; pfam09084 930170001742 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930170001743 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930170001744 Walker A/P-loop; other site 930170001745 ATP binding site [chemical binding]; other site 930170001746 Q-loop/lid; other site 930170001747 ABC transporter signature motif; other site 930170001748 Walker B; other site 930170001749 D-loop; other site 930170001750 H-loop/switch region; other site 930170001751 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170001752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170001753 Walker A/P-loop; other site 930170001754 ATP binding site [chemical binding]; other site 930170001755 Q-loop/lid; other site 930170001756 ABC transporter signature motif; other site 930170001757 Walker B; other site 930170001758 D-loop; other site 930170001759 H-loop/switch region; other site 930170001760 ABC transporter; Region: ABC_tran_2; pfam12848 930170001761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170001762 Glyco_18 domain; Region: Glyco_18; smart00636 930170001763 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 930170001764 active site 930170001765 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930170001766 Interdomain contacts; other site 930170001767 Cytokine receptor motif; other site 930170001768 CBD_II domain; Region: CBD_II; smart00637 930170001769 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 930170001770 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170001771 catalytic residues [active] 930170001772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170001773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170001774 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 930170001775 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170001777 putative substrate translocation pore; other site 930170001778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001779 non-specific DNA binding site [nucleotide binding]; other site 930170001780 salt bridge; other site 930170001781 sequence-specific DNA binding site [nucleotide binding]; other site 930170001782 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 930170001783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170001784 putative substrate translocation pore; other site 930170001785 Uncharacterized conserved protein [Function unknown]; Region: COG3379 930170001786 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 930170001787 YesK-like protein; Region: YesK; pfam14150 930170001788 prolyl-tRNA synthetase; Provisional; Region: PRK08661 930170001789 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 930170001790 dimer interface [polypeptide binding]; other site 930170001791 motif 1; other site 930170001792 active site 930170001793 motif 2; other site 930170001794 motif 3; other site 930170001795 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 930170001796 anticodon binding site; other site 930170001797 zinc-binding site [ion binding]; other site 930170001798 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930170001799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930170001800 nucleotide binding site [chemical binding]; other site 930170001801 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 930170001802 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 930170001803 putative metal binding site [ion binding]; other site 930170001804 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 930170001805 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 930170001806 putative metal binding site [ion binding]; other site 930170001807 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 930170001808 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 930170001809 putative metal binding site [ion binding]; other site 930170001810 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 930170001811 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 930170001812 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 930170001813 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 930170001814 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930170001815 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170001816 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930170001817 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 930170001818 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930170001819 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 930170001820 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930170001821 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930170001822 active site 930170001823 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 930170001824 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 930170001825 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 930170001826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170001827 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930170001828 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170001829 EamA-like transporter family; Region: EamA; pfam00892 930170001830 EamA-like transporter family; Region: EamA; pfam00892 930170001831 YhhN-like protein; Region: YhhN; pfam07947 930170001832 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930170001833 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170001834 Catalytic site [active] 930170001835 Tetratricopeptide repeat; Region: TPR_16; pfam13432 930170001836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170001837 binding surface 930170001838 TPR motif; other site 930170001839 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930170001840 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170001841 Predicted membrane protein [Function unknown]; Region: COG2510 930170001842 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 930170001843 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 930170001844 calcium/proton exchanger (cax); Region: cax; TIGR00378 930170001845 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 930170001846 YfkD-like protein; Region: YfkD; pfam14167 930170001847 Radical SAM superfamily; Region: Radical_SAM; pfam04055 930170001848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170001849 FeS/SAM binding site; other site 930170001850 YfkB-like domain; Region: YfkB; pfam08756 930170001851 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 930170001852 Fumarase C-terminus; Region: Fumerase_C; pfam05683 930170001853 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 930170001854 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 930170001855 NodB motif; other site 930170001856 active site 930170001857 catalytic site [active] 930170001858 Cd binding site [ion binding]; other site 930170001859 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930170001860 endonuclease III; Region: ENDO3c; smart00478 930170001861 minor groove reading motif; other site 930170001862 helix-hairpin-helix signature motif; other site 930170001863 substrate binding pocket [chemical binding]; other site 930170001864 active site 930170001865 TRAM domain; Region: TRAM; pfam01938 930170001866 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 930170001867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170001868 S-adenosylmethionine binding site [chemical binding]; other site 930170001869 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 930170001870 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 930170001871 dimerization interface 3.5A [polypeptide binding]; other site 930170001872 active site 930170001873 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 930170001874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170001875 Walker A motif; other site 930170001876 ATP binding site [chemical binding]; other site 930170001877 Walker B motif; other site 930170001878 arginine finger; other site 930170001879 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930170001880 hypothetical protein; Validated; Region: PRK06748 930170001881 S-methylmethionine transporter; Provisional; Region: PRK11387 930170001882 acetylornithine deacetylase; Validated; Region: PRK08596 930170001883 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 930170001884 metal binding site [ion binding]; metal-binding site 930170001885 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170001886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170001887 non-specific DNA binding site [nucleotide binding]; other site 930170001888 salt bridge; other site 930170001889 sequence-specific DNA binding site [nucleotide binding]; other site 930170001890 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 930170001891 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 930170001892 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 930170001893 glutaminase A; Region: Gln_ase; TIGR03814 930170001894 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 930170001895 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 930170001896 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170001897 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170001898 active site turn [active] 930170001899 phosphorylation site [posttranslational modification] 930170001900 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170001901 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170001902 Sm and related proteins; Region: Sm_like; cl00259 930170001903 heptamer interface [polypeptide binding]; other site 930170001904 Sm1 motif; other site 930170001905 hexamer interface [polypeptide binding]; other site 930170001906 RNA binding site [nucleotide binding]; other site 930170001907 Sm2 motif; other site 930170001908 Sm and related proteins; Region: Sm_like; cl00259 930170001909 heptamer interface [polypeptide binding]; other site 930170001910 Sm1 motif; other site 930170001911 hexamer interface [polypeptide binding]; other site 930170001912 RNA binding site [nucleotide binding]; other site 930170001913 Sm2 motif; other site 930170001914 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 930170001915 Ligand binding site; other site 930170001916 Putative Catalytic site; other site 930170001917 DXD motif; other site 930170001918 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170001919 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 930170001920 active site 930170001921 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 930170001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170001923 NAD(P) binding site [chemical binding]; other site 930170001924 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 930170001925 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 930170001926 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930170001927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170001928 NAD(P) binding site [chemical binding]; other site 930170001929 active site 930170001930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170001931 active site 930170001932 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170001933 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170001934 active site 930170001935 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 930170001936 Pyruvate formate lyase 1; Region: PFL1; cd01678 930170001937 coenzyme A binding site [chemical binding]; other site 930170001938 active site 930170001939 catalytic residues [active] 930170001940 glycine loop; other site 930170001941 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 930170001942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170001943 FeS/SAM binding site; other site 930170001944 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 930170001945 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 930170001946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930170001947 YfhE-like protein; Region: YfhE; pfam14152 930170001948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170001949 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 930170001950 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 930170001951 active site 930170001952 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 930170001953 TIGR01777 family protein; Region: yfcH 930170001954 putative NAD(P) binding site [chemical binding]; other site 930170001955 putative active site [active] 930170001956 recombination regulator RecX; Provisional; Region: recX; PRK14135 930170001957 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 930170001958 YpzG-like protein; Region: YpzG; pfam14139 930170001959 Small acid-soluble spore protein K family; Region: SspK; pfam08176 930170001960 WVELL protein; Region: WVELL; pfam14043 930170001961 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 930170001962 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 930170001963 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930170001964 minor groove reading motif; other site 930170001965 helix-hairpin-helix signature motif; other site 930170001966 substrate binding pocket [chemical binding]; other site 930170001967 active site 930170001968 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 930170001969 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 930170001970 DNA binding and oxoG recognition site [nucleotide binding] 930170001971 YgaB-like protein; Region: YgaB; pfam14182 930170001972 hypothetical protein; Provisional; Region: PRK13662 930170001973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170001974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170001975 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930170001976 Walker A/P-loop; other site 930170001977 ATP binding site [chemical binding]; other site 930170001978 Q-loop/lid; other site 930170001979 ABC transporter signature motif; other site 930170001980 Walker B; other site 930170001981 D-loop; other site 930170001982 H-loop/switch region; other site 930170001983 Predicted membrane protein [Function unknown]; Region: COG4129 930170001984 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 930170001985 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 930170001986 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 930170001987 active site 930170001988 dimer interface [polypeptide binding]; other site 930170001989 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 930170001990 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 930170001991 active site 930170001992 FMN binding site [chemical binding]; other site 930170001993 substrate binding site [chemical binding]; other site 930170001994 3Fe-4S cluster binding site [ion binding]; other site 930170001995 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 930170001996 domain_subunit interface; other site 930170001997 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 930170001998 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170001999 inhibitor-cofactor binding pocket; inhibition site 930170002000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170002001 catalytic residue [active] 930170002002 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 930170002003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170002004 Walker A/P-loop; other site 930170002005 ATP binding site [chemical binding]; other site 930170002006 Q-loop/lid; other site 930170002007 ABC transporter signature motif; other site 930170002008 Walker B; other site 930170002009 D-loop; other site 930170002010 H-loop/switch region; other site 930170002011 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 930170002012 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 930170002013 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 930170002014 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 930170002015 Ion channel; Region: Ion_trans_2; pfam07885 930170002016 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 930170002017 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 930170002018 catalytic triad [active] 930170002019 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930170002020 metal binding site 2 [ion binding]; metal-binding site 930170002021 putative DNA binding helix; other site 930170002022 metal binding site 1 [ion binding]; metal-binding site 930170002023 dimer interface [polypeptide binding]; other site 930170002024 structural Zn2+ binding site [ion binding]; other site 930170002025 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 930170002026 potential protein location (hypothetical protein YBT020_02935 [Bacillus thuringiensis YBT-020]) that overlaps RNA (tRNA-H) 930170002027 hypothetical protein; Provisional; Region: PRK12378 930170002028 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170002029 nudix motif; other site 930170002030 Transglycosylase; Region: Transgly; pfam00912 930170002031 Thioredoxin; Region: Thioredoxin_4; pfam13462 930170002032 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 930170002033 epoxyqueuosine reductase; Region: TIGR00276 930170002034 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 930170002035 Putative amidase domain; Region: Amidase_6; pfam12671 930170002036 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 930170002037 PAS fold; Region: PAS_4; pfam08448 930170002038 PAS domain; Region: PAS_9; pfam13426 930170002039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170002040 putative active site [active] 930170002041 heme pocket [chemical binding]; other site 930170002042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170002043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170002044 metal binding site [ion binding]; metal-binding site 930170002045 active site 930170002046 I-site; other site 930170002047 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170002048 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 930170002049 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 930170002050 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 930170002051 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170002052 heme-binding site [chemical binding]; other site 930170002053 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170002054 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930170002055 Leucine rich repeat; Region: LRR_8; pfam13855 930170002056 Substrate binding site [chemical binding]; other site 930170002057 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170002058 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170002059 Leucine rich repeat; Region: LRR_8; pfam13855 930170002060 Leucine rich repeat; Region: LRR_8; pfam13855 930170002061 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930170002062 Leucine rich repeat; Region: LRR_8; pfam13855 930170002063 MARCKS family; Region: MARCKS; pfam02063 930170002064 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 930170002065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170002066 substrate binding pocket [chemical binding]; other site 930170002067 membrane-bound complex binding site; other site 930170002068 hinge residues; other site 930170002069 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930170002070 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930170002071 Walker A/P-loop; other site 930170002072 ATP binding site [chemical binding]; other site 930170002073 Q-loop/lid; other site 930170002074 ABC transporter signature motif; other site 930170002075 Walker B; other site 930170002076 D-loop; other site 930170002077 H-loop/switch region; other site 930170002078 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930170002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002080 dimer interface [polypeptide binding]; other site 930170002081 conserved gate region; other site 930170002082 putative PBP binding loops; other site 930170002083 ABC-ATPase subunit interface; other site 930170002084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002085 dimer interface [polypeptide binding]; other site 930170002086 conserved gate region; other site 930170002087 putative PBP binding loops; other site 930170002088 ABC-ATPase subunit interface; other site 930170002089 BCCT family transporter; Region: BCCT; pfam02028 930170002090 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 930170002091 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 930170002092 FOG: PKD repeat [General function prediction only]; Region: COG3291 930170002093 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 930170002094 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 930170002095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 930170002096 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 930170002097 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 930170002098 Cache domain; Region: Cache_1; pfam02743 930170002099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170002100 dimerization interface [polypeptide binding]; other site 930170002101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170002102 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170002103 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170002104 dimer interface [polypeptide binding]; other site 930170002105 putative CheW interface [polypeptide binding]; other site 930170002106 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 930170002107 PAS domain; Region: PAS; smart00091 930170002108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170002109 ATP binding site [chemical binding]; other site 930170002110 Mg2+ binding site [ion binding]; other site 930170002111 G-X-G motif; other site 930170002112 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 930170002113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170002114 active site 930170002115 phosphorylation site [posttranslational modification] 930170002116 intermolecular recognition site; other site 930170002117 dimerization interface [polypeptide binding]; other site 930170002118 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 930170002119 Citrate transporter; Region: CitMHS; pfam03600 930170002120 hypothetical protein; Provisional; Region: PRK12784 930170002121 NosL; Region: NosL; cl01769 930170002122 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930170002123 Ankyrin repeat; Region: Ank; pfam00023 930170002124 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930170002125 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930170002126 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 930170002127 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 930170002128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170002129 Walker A/P-loop; other site 930170002130 ATP binding site [chemical binding]; other site 930170002131 Q-loop/lid; other site 930170002132 ABC transporter signature motif; other site 930170002133 Walker B; other site 930170002134 D-loop; other site 930170002135 H-loop/switch region; other site 930170002136 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930170002137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002138 dimer interface [polypeptide binding]; other site 930170002139 putative PBP binding loops; other site 930170002140 ABC-ATPase subunit interface; other site 930170002141 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930170002142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930170002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002144 dimer interface [polypeptide binding]; other site 930170002145 conserved gate region; other site 930170002146 putative PBP binding loops; other site 930170002147 ABC-ATPase subunit interface; other site 930170002148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930170002149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930170002150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170002151 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 930170002152 active site 930170002153 metal binding site [ion binding]; metal-binding site 930170002154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170002155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170002156 active site 930170002157 phosphorylation site [posttranslational modification] 930170002158 intermolecular recognition site; other site 930170002159 dimerization interface [polypeptide binding]; other site 930170002160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170002161 DNA binding site [nucleotide binding] 930170002162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170002163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170002164 dimer interface [polypeptide binding]; other site 930170002165 phosphorylation site [posttranslational modification] 930170002166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170002167 ATP binding site [chemical binding]; other site 930170002168 Mg2+ binding site [ion binding]; other site 930170002169 G-X-G motif; other site 930170002170 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930170002171 putative active site [active] 930170002172 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 930170002173 Cache domain; Region: Cache_1; pfam02743 930170002174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170002175 dimerization interface [polypeptide binding]; other site 930170002176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170002177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170002178 dimer interface [polypeptide binding]; other site 930170002179 putative CheW interface [polypeptide binding]; other site 930170002180 sensory histidine kinase DcuS; Provisional; Region: PRK11086 930170002181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170002182 ATP binding site [chemical binding]; other site 930170002183 Mg2+ binding site [ion binding]; other site 930170002184 G-X-G motif; other site 930170002185 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 930170002186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170002187 active site 930170002188 phosphorylation site [posttranslational modification] 930170002189 intermolecular recognition site; other site 930170002190 dimerization interface [polypeptide binding]; other site 930170002191 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 930170002192 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 930170002193 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930170002194 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 930170002195 putative NAD(P) binding site [chemical binding]; other site 930170002196 EamA-like transporter family; Region: EamA; pfam00892 930170002197 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170002198 EamA-like transporter family; Region: EamA; pfam00892 930170002199 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170002200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170002201 DNA-binding site [nucleotide binding]; DNA binding site 930170002202 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170002203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170002204 homodimer interface [polypeptide binding]; other site 930170002205 catalytic residue [active] 930170002206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 930170002207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170002208 Coenzyme A binding pocket [chemical binding]; other site 930170002209 potential frameshift: common BLAST hit: gi|42781520|ref|NP_978767.1| IS4 family transposase 930170002210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170002211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170002212 dimerization interface [polypeptide binding]; other site 930170002213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170002214 dimer interface [polypeptide binding]; other site 930170002215 phosphorylation site [posttranslational modification] 930170002216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170002217 ATP binding site [chemical binding]; other site 930170002218 Mg2+ binding site [ion binding]; other site 930170002219 G-X-G motif; other site 930170002220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170002221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170002222 active site 930170002223 phosphorylation site [posttranslational modification] 930170002224 intermolecular recognition site; other site 930170002225 dimerization interface [polypeptide binding]; other site 930170002226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170002227 DNA binding site [nucleotide binding] 930170002228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 930170002229 Arrestin_N terminal like; Region: LDB19; pfam13002 930170002230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170002231 Coenzyme A binding pocket [chemical binding]; other site 930170002232 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 930170002233 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930170002234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930170002235 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930170002236 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 930170002237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930170002238 catalytic loop [active] 930170002239 iron binding site [ion binding]; other site 930170002240 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 930170002241 4Fe-4S binding domain; Region: Fer4; pfam00037 930170002242 4Fe-4S binding domain; Region: Fer4; pfam00037 930170002243 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 930170002244 [4Fe-4S] binding site [ion binding]; other site 930170002245 molybdopterin cofactor binding site; other site 930170002246 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 930170002247 molybdopterin cofactor binding site; other site 930170002248 Uncharacterized conserved protein [Function unknown]; Region: COG2427 930170002249 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 930170002250 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930170002251 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 930170002252 putative active site [active] 930170002253 catalytic site [active] 930170002254 putative metal binding site [ion binding]; other site 930170002255 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 930170002256 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 930170002257 hexamer interface [polypeptide binding]; other site 930170002258 ligand binding site [chemical binding]; other site 930170002259 putative active site [active] 930170002260 NAD(P) binding site [chemical binding]; other site 930170002261 amino acid transporter; Region: 2A0306; TIGR00909 930170002262 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930170002263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170002264 dimerization interface [polypeptide binding]; other site 930170002265 putative DNA binding site [nucleotide binding]; other site 930170002266 putative Zn2+ binding site [ion binding]; other site 930170002267 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930170002268 metal-binding site [ion binding] 930170002269 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930170002270 Heavy-metal-associated domain; Region: HMA; pfam00403 930170002271 metal-binding site [ion binding] 930170002272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170002273 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930170002274 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 930170002275 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 930170002276 active site 930170002277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170002278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170002279 non-specific DNA binding site [nucleotide binding]; other site 930170002280 salt bridge; other site 930170002281 sequence-specific DNA binding site [nucleotide binding]; other site 930170002282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170002283 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930170002284 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930170002285 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930170002286 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930170002287 active site 930170002288 Zn binding site [ion binding]; other site 930170002289 Uncharacterized conserved protein [Function unknown]; Region: COG0398 930170002290 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170002291 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 930170002292 VanW like protein; Region: VanW; pfam04294 930170002293 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 930170002294 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170002295 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170002296 Nucleoside recognition; Region: Gate; pfam07670 930170002297 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170002298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170002299 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 930170002300 putative metal binding site [ion binding]; other site 930170002301 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930170002302 Domain of unknown function DUF21; Region: DUF21; pfam01595 930170002303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930170002304 Transporter associated domain; Region: CorC_HlyC; smart01091 930170002305 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 930170002306 Aspartase; Region: Aspartase; cd01357 930170002307 active sites [active] 930170002308 tetramer interface [polypeptide binding]; other site 930170002309 L-lactate permease; Region: Lactate_perm; cl00701 930170002310 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 930170002311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170002312 dimerization interface [polypeptide binding]; other site 930170002313 putative Zn2+ binding site [ion binding]; other site 930170002314 putative DNA binding site [nucleotide binding]; other site 930170002315 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 930170002316 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 930170002317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002318 putative substrate translocation pore; other site 930170002319 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 930170002320 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930170002321 siderophore binding site; other site 930170002322 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170002323 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170002324 ABC-ATPase subunit interface; other site 930170002325 dimer interface [polypeptide binding]; other site 930170002326 putative PBP binding regions; other site 930170002327 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930170002328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170002329 ABC-ATPase subunit interface; other site 930170002330 dimer interface [polypeptide binding]; other site 930170002331 putative PBP binding regions; other site 930170002332 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170002333 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930170002334 Walker A/P-loop; other site 930170002335 ATP binding site [chemical binding]; other site 930170002336 Q-loop/lid; other site 930170002337 ABC transporter signature motif; other site 930170002338 Walker B; other site 930170002339 D-loop; other site 930170002340 H-loop/switch region; other site 930170002341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170002342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170002343 S-adenosylmethionine binding site [chemical binding]; other site 930170002344 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 930170002345 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 930170002346 substrate-cofactor binding pocket; other site 930170002347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170002348 catalytic residue [active] 930170002349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930170002350 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 930170002351 NAD binding site [chemical binding]; other site 930170002352 homodimer interface [polypeptide binding]; other site 930170002353 active site 930170002354 putative substrate binding site [chemical binding]; other site 930170002355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170002356 active site 930170002357 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170002358 nudix motif; other site 930170002359 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 930170002360 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 930170002361 metal ion-dependent adhesion site (MIDAS); other site 930170002362 MoxR-like ATPases [General function prediction only]; Region: COG0714 930170002363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170002364 Walker A motif; other site 930170002365 ATP binding site [chemical binding]; other site 930170002366 Walker B motif; other site 930170002367 arginine finger; other site 930170002368 cardiolipin synthetase; Reviewed; Region: PRK12452 930170002369 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930170002370 putative active site [active] 930170002371 catalytic site [active] 930170002372 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930170002373 putative active site [active] 930170002374 catalytic site [active] 930170002375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170002376 PAS domain; Region: PAS_9; pfam13426 930170002377 putative active site [active] 930170002378 heme pocket [chemical binding]; other site 930170002379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170002380 metal binding site [ion binding]; metal-binding site 930170002381 active site 930170002382 I-site; other site 930170002383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170002384 Amino acid permease; Region: AA_permease_2; pfam13520 930170002385 Spore germination protein; Region: Spore_permease; cl17796 930170002386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170002387 DNA-binding site [nucleotide binding]; DNA binding site 930170002388 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 930170002389 UTRA domain; Region: UTRA; pfam07702 930170002390 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 930170002391 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170002392 active site turn [active] 930170002393 phosphorylation site [posttranslational modification] 930170002394 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170002395 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930170002396 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930170002397 Ca binding site [ion binding]; other site 930170002398 active site 930170002399 catalytic site [active] 930170002400 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170002401 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170002402 Spore germination protein; Region: Spore_permease; cl17796 930170002403 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170002404 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170002405 active site 930170002406 ATP binding site [chemical binding]; other site 930170002407 substrate binding site [chemical binding]; other site 930170002408 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170002409 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 930170002410 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930170002411 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930170002412 Walker A/P-loop; other site 930170002413 ATP binding site [chemical binding]; other site 930170002414 Q-loop/lid; other site 930170002415 ABC transporter signature motif; other site 930170002416 Walker B; other site 930170002417 D-loop; other site 930170002418 H-loop/switch region; other site 930170002419 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 930170002420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170002421 substrate binding pocket [chemical binding]; other site 930170002422 membrane-bound complex binding site; other site 930170002423 hinge residues; other site 930170002424 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930170002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002426 dimer interface [polypeptide binding]; other site 930170002427 conserved gate region; other site 930170002428 putative PBP binding loops; other site 930170002429 ABC-ATPase subunit interface; other site 930170002430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002431 dimer interface [polypeptide binding]; other site 930170002432 conserved gate region; other site 930170002433 putative PBP binding loops; other site 930170002434 ABC-ATPase subunit interface; other site 930170002435 S-methylmethionine transporter; Provisional; Region: PRK11387 930170002436 OsmC-like protein; Region: OsmC; pfam02566 930170002437 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 930170002438 nucleotide binding site/active site [active] 930170002439 HIT family signature motif; other site 930170002440 catalytic residue [active] 930170002441 RNA polymerase sigma factor; Provisional; Region: PRK12542 930170002442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170002443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170002444 DNA binding residues [nucleotide binding] 930170002445 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 930170002446 Predicted transcriptional regulator [Transcription]; Region: COG2378 930170002447 HTH domain; Region: HTH_11; pfam08279 930170002448 WYL domain; Region: WYL; pfam13280 930170002449 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930170002450 RibD C-terminal domain; Region: RibD_C; cl17279 930170002451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170002452 dimerization interface [polypeptide binding]; other site 930170002453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170002454 dimer interface [polypeptide binding]; other site 930170002455 phosphorylation site [posttranslational modification] 930170002456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170002457 ATP binding site [chemical binding]; other site 930170002458 Mg2+ binding site [ion binding]; other site 930170002459 G-X-G motif; other site 930170002460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170002461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170002462 active site 930170002463 phosphorylation site [posttranslational modification] 930170002464 intermolecular recognition site; other site 930170002465 dimerization interface [polypeptide binding]; other site 930170002466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170002467 DNA binding site [nucleotide binding] 930170002468 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 930170002469 Probable transposase; Region: OrfB_IS605; pfam01385 930170002470 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170002471 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170002472 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 930170002473 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930170002474 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930170002475 Ligand Binding Site [chemical binding]; other site 930170002476 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 930170002477 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 930170002478 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 930170002479 peptide binding site [polypeptide binding]; other site 930170002480 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 930170002481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002482 dimer interface [polypeptide binding]; other site 930170002483 conserved gate region; other site 930170002484 putative PBP binding loops; other site 930170002485 ABC-ATPase subunit interface; other site 930170002486 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170002487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002488 putative PBP binding loops; other site 930170002489 ABC-ATPase subunit interface; other site 930170002490 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930170002491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170002492 Walker A/P-loop; other site 930170002493 ATP binding site [chemical binding]; other site 930170002494 Q-loop/lid; other site 930170002495 ABC transporter signature motif; other site 930170002496 Walker B; other site 930170002497 D-loop; other site 930170002498 H-loop/switch region; other site 930170002499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 930170002500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930170002501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170002502 Walker A/P-loop; other site 930170002503 ATP binding site [chemical binding]; other site 930170002504 Q-loop/lid; other site 930170002505 ABC transporter signature motif; other site 930170002506 Walker B; other site 930170002507 D-loop; other site 930170002508 H-loop/switch region; other site 930170002509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930170002510 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 930170002511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002512 putative substrate translocation pore; other site 930170002513 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170002514 MarR family; Region: MarR; pfam01047 930170002515 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930170002516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002517 putative substrate translocation pore; other site 930170002518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170002519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170002520 DNA binding site [nucleotide binding] 930170002521 domain linker motif; other site 930170002522 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 930170002523 dimerization interface [polypeptide binding]; other site 930170002524 ligand binding site [chemical binding]; other site 930170002525 sodium binding site [ion binding]; other site 930170002526 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930170002527 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 930170002528 substrate binding site [chemical binding]; other site 930170002529 dimer interface [polypeptide binding]; other site 930170002530 ATP binding site [chemical binding]; other site 930170002531 D-ribose pyranase; Provisional; Region: PRK11797 930170002532 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930170002533 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930170002534 Walker A/P-loop; other site 930170002535 ATP binding site [chemical binding]; other site 930170002536 Q-loop/lid; other site 930170002537 ABC transporter signature motif; other site 930170002538 Walker B; other site 930170002539 D-loop; other site 930170002540 H-loop/switch region; other site 930170002541 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930170002542 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170002543 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930170002544 TM-ABC transporter signature motif; other site 930170002545 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 930170002546 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930170002547 ligand binding site [chemical binding]; other site 930170002548 dimerization interface [polypeptide binding]; other site 930170002549 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 930170002550 active site 930170002551 intersubunit interactions; other site 930170002552 catalytic residue [active] 930170002553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 930170002554 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 930170002555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170002557 putative substrate translocation pore; other site 930170002558 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930170002559 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 930170002560 putative NAD(P) binding site [chemical binding]; other site 930170002561 catalytic Zn binding site [ion binding]; other site 930170002562 Ion channel; Region: Ion_trans_2; pfam07885 930170002563 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 930170002564 Zn binding site [ion binding]; other site 930170002565 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 930170002566 putative catalytic site [active] 930170002567 metal binding site A [ion binding]; metal-binding site 930170002568 phosphate binding site [ion binding]; other site 930170002569 metal binding site C [ion binding]; metal-binding site 930170002570 metal binding site B [ion binding]; metal-binding site 930170002571 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 930170002572 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 930170002573 dimer interface [polypeptide binding]; other site 930170002574 active site 930170002575 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930170002576 substrate binding site [chemical binding]; other site 930170002577 catalytic residue [active] 930170002578 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 930170002579 FAD binding domain; Region: FAD_binding_4; pfam01565 930170002580 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 930170002581 VanZ like family; Region: VanZ; pfam04892 930170002582 RDD family; Region: RDD; pfam06271 930170002583 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 930170002584 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170002585 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170002586 dimer interface [polypeptide binding]; other site 930170002587 putative CheW interface [polypeptide binding]; other site 930170002588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 930170002589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930170002590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170002591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170002592 non-specific DNA binding site [nucleotide binding]; other site 930170002593 salt bridge; other site 930170002594 sequence-specific DNA binding site [nucleotide binding]; other site 930170002595 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 930170002596 active site 930170002597 catalytic site [active] 930170002598 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 930170002599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002600 putative substrate translocation pore; other site 930170002601 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 930170002602 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 930170002603 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 930170002604 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 930170002605 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930170002606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170002607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170002608 non-specific DNA binding site [nucleotide binding]; other site 930170002609 salt bridge; other site 930170002610 sequence-specific DNA binding site [nucleotide binding]; other site 930170002611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170002612 Coenzyme A binding pocket [chemical binding]; other site 930170002613 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 930170002614 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930170002615 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930170002616 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930170002617 TrkA-N domain; Region: TrkA_N; pfam02254 930170002618 TrkA-C domain; Region: TrkA_C; pfam02080 930170002619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 930170002620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170002621 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930170002622 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 930170002623 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 930170002624 Subunit I/III interface [polypeptide binding]; other site 930170002625 Subunit III/IV interface [polypeptide binding]; other site 930170002626 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 930170002627 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 930170002628 D-pathway; other site 930170002629 Putative ubiquinol binding site [chemical binding]; other site 930170002630 Low-spin heme (heme b) binding site [chemical binding]; other site 930170002631 Putative water exit pathway; other site 930170002632 Binuclear center (heme o3/CuB) [ion binding]; other site 930170002633 K-pathway; other site 930170002634 Putative proton exit pathway; other site 930170002635 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 930170002636 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 930170002637 S-methylmethionine transporter; Provisional; Region: PRK11387 930170002638 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930170002639 putative active site [active] 930170002640 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930170002641 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930170002642 metal binding site [ion binding]; metal-binding site 930170002643 dimer interface [polypeptide binding]; other site 930170002644 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 930170002645 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 930170002646 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 930170002647 Na binding site [ion binding]; other site 930170002648 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170002649 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 930170002650 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170002651 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170002652 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 930170002653 Nucleoside recognition; Region: Gate; pfam07670 930170002654 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 930170002655 Nucleoside recognition; Region: Gate; pfam07670 930170002656 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 930170002657 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 930170002658 G1 box; other site 930170002659 GTP/Mg2+ binding site [chemical binding]; other site 930170002660 Switch I region; other site 930170002661 G2 box; other site 930170002662 G3 box; other site 930170002663 Switch II region; other site 930170002664 G4 box; other site 930170002665 G5 box; other site 930170002666 FeoA domain; Region: FeoA; pfam04023 930170002667 phosphate binding protein; Region: ptsS_2; TIGR02136 930170002668 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 930170002669 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 930170002670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002671 dimer interface [polypeptide binding]; other site 930170002672 conserved gate region; other site 930170002673 putative PBP binding loops; other site 930170002674 ABC-ATPase subunit interface; other site 930170002675 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 930170002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002677 dimer interface [polypeptide binding]; other site 930170002678 conserved gate region; other site 930170002679 putative PBP binding loops; other site 930170002680 ABC-ATPase subunit interface; other site 930170002681 AAA domain; Region: AAA_33; pfam13671 930170002682 AAA domain; Region: AAA_17; pfam13207 930170002683 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 930170002684 potential protein location (hypothetical protein YBT020_03880 [Bacillus thuringiensis YBT-020]) that overlaps RNA (tRNA-A) 930170002685 FOG: CBS domain [General function prediction only]; Region: COG0517 930170002686 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 930170002687 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 930170002688 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 930170002689 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170002690 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170002691 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170002692 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170002693 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170002694 Putative transcription activator [Transcription]; Region: TenA; COG0819 930170002695 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930170002696 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930170002697 Walker A/P-loop; other site 930170002698 ATP binding site [chemical binding]; other site 930170002699 Q-loop/lid; other site 930170002700 ABC transporter signature motif; other site 930170002701 Walker B; other site 930170002702 D-loop; other site 930170002703 H-loop/switch region; other site 930170002704 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930170002705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002706 dimer interface [polypeptide binding]; other site 930170002707 conserved gate region; other site 930170002708 putative PBP binding loops; other site 930170002709 ABC-ATPase subunit interface; other site 930170002710 NMT1/THI5 like; Region: NMT1; pfam09084 930170002711 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 930170002712 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 930170002713 thiamine phosphate binding site [chemical binding]; other site 930170002714 active site 930170002715 pyrophosphate binding site [ion binding]; other site 930170002716 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 930170002717 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 930170002718 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 930170002719 thiS-thiF/thiG interaction site; other site 930170002720 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 930170002721 ThiS interaction site; other site 930170002722 putative active site [active] 930170002723 tetramer interface [polypeptide binding]; other site 930170002724 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 930170002725 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930170002726 ATP binding site [chemical binding]; other site 930170002727 substrate interface [chemical binding]; other site 930170002728 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930170002729 dimer interface [polypeptide binding]; other site 930170002730 substrate binding site [chemical binding]; other site 930170002731 ATP binding site [chemical binding]; other site 930170002732 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 930170002733 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 930170002734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170002735 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930170002736 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 930170002737 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 930170002738 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 930170002739 Ligand Binding Site [chemical binding]; other site 930170002740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170002742 putative substrate translocation pore; other site 930170002743 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170002744 MarR family; Region: MarR; pfam01047 930170002745 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 930170002746 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 930170002747 active site 930170002748 nucleophile elbow; other site 930170002749 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170002750 FtsX-like permease family; Region: FtsX; pfam02687 930170002751 FtsX-like permease family; Region: FtsX; pfam02687 930170002752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170002753 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170002754 Walker A/P-loop; other site 930170002755 ATP binding site [chemical binding]; other site 930170002756 Q-loop/lid; other site 930170002757 ABC transporter signature motif; other site 930170002758 Walker B; other site 930170002759 D-loop; other site 930170002760 H-loop/switch region; other site 930170002761 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930170002762 short chain dehydrogenase; Provisional; Region: PRK06701 930170002763 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 930170002764 NAD binding site [chemical binding]; other site 930170002765 metal binding site [ion binding]; metal-binding site 930170002766 active site 930170002767 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 930170002768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 930170002769 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930170002770 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 930170002771 putative substrate binding site [chemical binding]; other site 930170002772 putative ATP binding site [chemical binding]; other site 930170002773 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 930170002774 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 930170002775 substrate binding [chemical binding]; other site 930170002776 active site 930170002777 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 930170002778 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 930170002779 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170002780 active site turn [active] 930170002781 phosphorylation site [posttranslational modification] 930170002782 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170002783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170002784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170002785 DNA binding site [nucleotide binding] 930170002786 domain linker motif; other site 930170002787 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 930170002788 dimerization interface [polypeptide binding]; other site 930170002789 ligand binding site [chemical binding]; other site 930170002790 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170002791 catalytic residues [active] 930170002792 putative disulfide oxidoreductase; Provisional; Region: PRK03113 930170002793 YhdB-like protein; Region: YhdB; pfam14148 930170002794 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 930170002795 Spore germination protein; Region: Spore_permease; cl17796 930170002796 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170002797 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170002798 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170002799 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 930170002800 putative FMN binding site [chemical binding]; other site 930170002801 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 930170002802 SpoVR like protein; Region: SpoVR; pfam04293 930170002803 Restriction endonuclease; Region: Mrr_cat; pfam04471 930170002804 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 930170002805 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 930170002806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170002807 putative DNA binding site [nucleotide binding]; other site 930170002808 putative Zn2+ binding site [ion binding]; other site 930170002809 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170002810 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 930170002811 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 930170002812 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 930170002813 putative homodimer interface [polypeptide binding]; other site 930170002814 putative homotetramer interface [polypeptide binding]; other site 930170002815 putative metal binding site [ion binding]; other site 930170002816 putative homodimer-homodimer interface [polypeptide binding]; other site 930170002817 putative allosteric switch controlling residues; other site 930170002818 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 930170002819 CPxP motif; other site 930170002820 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930170002821 active site residue [active] 930170002822 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 930170002823 active site residue [active] 930170002824 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170002825 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 930170002826 CPxP motif; other site 930170002827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930170002828 active site residue [active] 930170002829 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930170002830 active site residue [active] 930170002831 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 930170002832 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170002833 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 930170002834 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 930170002835 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 930170002836 NADP binding site [chemical binding]; other site 930170002837 dimer interface [polypeptide binding]; other site 930170002838 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 930170002839 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 930170002840 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 930170002841 PhoU domain; Region: PhoU; pfam01895 930170002842 PhoU domain; Region: PhoU; pfam01895 930170002843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002844 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170002845 putative substrate translocation pore; other site 930170002846 Uncharacterized conserved protein [Function unknown]; Region: COG3589 930170002847 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 930170002848 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930170002849 HTH domain; Region: HTH_11; pfam08279 930170002850 Mga helix-turn-helix domain; Region: Mga; pfam05043 930170002851 PRD domain; Region: PRD; pfam00874 930170002852 PRD domain; Region: PRD; pfam00874 930170002853 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930170002854 active site 930170002855 P-loop; other site 930170002856 phosphorylation site [posttranslational modification] 930170002857 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930170002858 active site 930170002859 phosphorylation site [posttranslational modification] 930170002860 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930170002861 active site 930170002862 methionine cluster; other site 930170002863 phosphorylation site [posttranslational modification] 930170002864 metal binding site [ion binding]; metal-binding site 930170002865 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930170002866 active site 930170002867 P-loop; other site 930170002868 phosphorylation site [posttranslational modification] 930170002869 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930170002870 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930170002871 Uncharacterized conserved protein [Function unknown]; Region: COG3589 930170002872 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 930170002873 HEAT repeats; Region: HEAT_2; pfam13646 930170002874 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170002875 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170002876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930170002877 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930170002878 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170002879 FtsX-like permease family; Region: FtsX; pfam02687 930170002880 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170002881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170002882 Walker A/P-loop; other site 930170002883 ATP binding site [chemical binding]; other site 930170002884 Q-loop/lid; other site 930170002885 ABC transporter signature motif; other site 930170002886 Walker B; other site 930170002887 D-loop; other site 930170002888 H-loop/switch region; other site 930170002889 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930170002890 HlyD family secretion protein; Region: HlyD_3; pfam13437 930170002891 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 930170002892 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 930170002893 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170002894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170002895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170002896 dimer interface [polypeptide binding]; other site 930170002897 conserved gate region; other site 930170002898 ABC-ATPase subunit interface; other site 930170002899 FtsX-like permease family; Region: FtsX; pfam02687 930170002900 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170002901 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 930170002902 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 930170002903 dimanganese center [ion binding]; other site 930170002904 CotJB protein; Region: CotJB; pfam12652 930170002905 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 930170002906 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930170002907 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170002908 active site 930170002909 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 930170002910 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 930170002911 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 930170002912 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 930170002913 putative DNA binding site [nucleotide binding]; other site 930170002914 putative homodimer interface [polypeptide binding]; other site 930170002915 Uncharacterized conserved protein [Function unknown]; Region: COG3339 930170002916 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930170002917 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170002918 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 930170002919 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 930170002920 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 930170002921 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170002922 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 930170002923 active site 930170002924 metal binding site [ion binding]; metal-binding site 930170002925 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930170002926 Interdomain contacts; other site 930170002927 Cytokine receptor motif; other site 930170002928 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 930170002929 amino acid transporter; Region: 2A0306; TIGR00909 930170002930 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930170002931 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930170002932 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930170002933 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930170002934 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930170002935 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930170002936 putative active site [active] 930170002937 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 930170002938 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 930170002939 putative active site [active] 930170002940 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170002941 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 930170002942 active site turn [active] 930170002943 phosphorylation site [posttranslational modification] 930170002944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170002945 Uncharacterized conserved protein [Function unknown]; Region: COG3589 930170002946 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 930170002947 DoxX; Region: DoxX; pfam07681 930170002948 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 930170002949 hypothetical protein; Provisional; Region: PRK06770 930170002950 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170002951 EamA-like transporter family; Region: EamA; pfam00892 930170002952 EamA-like transporter family; Region: EamA; pfam00892 930170002953 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930170002954 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930170002955 AsnC family; Region: AsnC_trans_reg; pfam01037 930170002956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170002957 Coenzyme A binding pocket [chemical binding]; other site 930170002958 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170002959 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170002960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170002961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170002962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170002964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002965 Predicted transcriptional regulators [Transcription]; Region: COG1733 930170002966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170002967 dimerization interface [polypeptide binding]; other site 930170002968 putative DNA binding site [nucleotide binding]; other site 930170002969 putative Zn2+ binding site [ion binding]; other site 930170002970 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 930170002971 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170002972 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 930170002973 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 930170002974 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 930170002975 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 930170002976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170002977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170002978 putative substrate translocation pore; other site 930170002979 intracellular protease, PfpI family; Region: PfpI; TIGR01382 930170002980 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 930170002981 proposed catalytic triad [active] 930170002982 conserved cys residue [active] 930170002983 hydroperoxidase II; Provisional; Region: katE; PRK11249 930170002984 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 930170002985 tetramer interface [polypeptide binding]; other site 930170002986 heme binding pocket [chemical binding]; other site 930170002987 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 930170002988 domain interactions; other site 930170002989 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 930170002990 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 930170002991 Spore germination protein; Region: Spore_permease; cl17796 930170002992 glutamate racemase; Provisional; Region: PRK00865 930170002993 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 930170002994 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 930170002995 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 930170002996 tetrameric interface [polypeptide binding]; other site 930170002997 activator binding site; other site 930170002998 NADP binding site [chemical binding]; other site 930170002999 substrate binding site [chemical binding]; other site 930170003000 catalytic residues [active] 930170003001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170003002 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 930170003003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170003004 Walker A/P-loop; other site 930170003005 ATP binding site [chemical binding]; other site 930170003006 Q-loop/lid; other site 930170003007 ABC transporter signature motif; other site 930170003008 Walker B; other site 930170003009 D-loop; other site 930170003010 H-loop/switch region; other site 930170003011 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170003012 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 930170003013 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930170003014 Walker A/P-loop; other site 930170003015 ATP binding site [chemical binding]; other site 930170003016 Q-loop/lid; other site 930170003017 ABC transporter signature motif; other site 930170003018 Walker B; other site 930170003019 D-loop; other site 930170003020 H-loop/switch region; other site 930170003021 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930170003022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170003023 substrate binding pocket [chemical binding]; other site 930170003024 membrane-bound complex binding site; other site 930170003025 hinge residues; other site 930170003026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170003027 dimer interface [polypeptide binding]; other site 930170003028 conserved gate region; other site 930170003029 putative PBP binding loops; other site 930170003030 ABC-ATPase subunit interface; other site 930170003031 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930170003032 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930170003033 Walker A/P-loop; other site 930170003034 ATP binding site [chemical binding]; other site 930170003035 Q-loop/lid; other site 930170003036 ABC transporter signature motif; other site 930170003037 Walker B; other site 930170003038 D-loop; other site 930170003039 H-loop/switch region; other site 930170003040 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170003041 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 930170003042 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 930170003043 Protein of unknown function (DUF445); Region: DUF445; pfam04286 930170003044 hypothetical protein; Provisional; Region: PRK13676 930170003045 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 930170003046 acetolactate synthase; Reviewed; Region: PRK08617 930170003047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930170003048 PYR/PP interface [polypeptide binding]; other site 930170003049 dimer interface [polypeptide binding]; other site 930170003050 TPP binding site [chemical binding]; other site 930170003051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170003052 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 930170003053 TPP-binding site [chemical binding]; other site 930170003054 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 930170003055 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 930170003056 active site 930170003057 DNA binding site [nucleotide binding] 930170003058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 930170003059 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170003060 active site 930170003061 motif I; other site 930170003062 motif II; other site 930170003063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170003064 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170003065 amidase catalytic site [active] 930170003066 Zn binding residues [ion binding]; other site 930170003067 substrate binding site [chemical binding]; other site 930170003068 S-layer homology domain; Region: SLH; pfam00395 930170003069 S-layer homology domain; Region: SLH; pfam00395 930170003070 S-layer homology domain; Region: SLH; pfam00395 930170003071 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 930170003072 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 930170003073 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170003074 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 930170003075 acyl-activating enzyme (AAE) consensus motif; other site 930170003076 acyl-activating enzyme (AAE) consensus motif; other site 930170003077 putative AMP binding site [chemical binding]; other site 930170003078 putative active site [active] 930170003079 putative CoA binding site [chemical binding]; other site 930170003080 putative transposase OrfB; Reviewed; Region: PHA02517 930170003081 HTH-like domain; Region: HTH_21; pfam13276 930170003082 Integrase core domain; Region: rve; pfam00665 930170003083 Integrase core domain; Region: rve_2; pfam13333 930170003084 high affinity sulphate transporter 1; Region: sulP; TIGR00815 930170003085 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930170003086 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930170003087 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 930170003088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930170003089 ATP binding site [chemical binding]; other site 930170003090 putative Mg++ binding site [ion binding]; other site 930170003091 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930170003092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 930170003093 nucleotide binding region [chemical binding]; other site 930170003094 ATP-binding site [chemical binding]; other site 930170003095 stage V sporulation protein B; Region: spore_V_B; TIGR02900 930170003096 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930170003097 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 930170003098 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 930170003099 S-layer homology domain; Region: SLH; pfam00395 930170003100 S-layer homology domain; Region: SLH; pfam00395 930170003101 S-layer homology domain; Region: SLH; pfam00395 930170003102 S-layer homology domain; Region: SLH; pfam00395 930170003103 S-layer homology domain; Region: SLH; pfam00395 930170003104 S-layer homology domain; Region: SLH; pfam00395 930170003105 DHHW protein; Region: DHHW; pfam14286 930170003106 DHHW protein; Region: DHHW; pfam14286 930170003107 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 930170003108 enoyl-CoA hydratase; Provisional; Region: PRK07659 930170003109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930170003110 substrate binding site [chemical binding]; other site 930170003111 oxyanion hole (OAH) forming residues; other site 930170003112 trimer interface [polypeptide binding]; other site 930170003113 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 930170003114 metal binding site [ion binding]; metal-binding site 930170003115 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930170003116 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 930170003117 putative oligomer interface [polypeptide binding]; other site 930170003118 putative active site [active] 930170003119 metal binding site [ion binding]; metal-binding site 930170003120 S-layer homology domain; Region: SLH; pfam00395 930170003121 S-layer homology domain; Region: SLH; pfam00395 930170003122 S-layer homology domain; Region: SLH; pfam00395 930170003123 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930170003124 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930170003125 active site 930170003126 metal binding site [ion binding]; metal-binding site 930170003127 TIGR01177 family protein; Region: TIGR01177 930170003128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170003129 S-adenosylmethionine binding site [chemical binding]; other site 930170003130 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930170003131 MULE transposase domain; Region: MULE; pfam10551 930170003132 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 930170003133 proline racemase; Provisional; Region: PRK13969 930170003134 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 930170003135 ornithine cyclodeaminase; Validated; Region: PRK08618 930170003136 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930170003137 NAD(P) binding site [chemical binding]; other site 930170003138 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930170003139 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 930170003140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170003141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170003142 dimer interface [polypeptide binding]; other site 930170003143 conserved gate region; other site 930170003144 putative PBP binding loops; other site 930170003145 ABC-ATPase subunit interface; other site 930170003146 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170003147 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930170003148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170003149 dimer interface [polypeptide binding]; other site 930170003150 conserved gate region; other site 930170003151 putative PBP binding loops; other site 930170003152 ABC-ATPase subunit interface; other site 930170003153 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930170003154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170003155 Walker A/P-loop; other site 930170003156 ATP binding site [chemical binding]; other site 930170003157 Q-loop/lid; other site 930170003158 ABC transporter signature motif; other site 930170003159 Walker B; other site 930170003160 D-loop; other site 930170003161 H-loop/switch region; other site 930170003162 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 930170003163 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 930170003164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170003165 Walker A/P-loop; other site 930170003166 ATP binding site [chemical binding]; other site 930170003167 Q-loop/lid; other site 930170003168 ABC transporter signature motif; other site 930170003169 Walker B; other site 930170003170 D-loop; other site 930170003171 H-loop/switch region; other site 930170003172 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 930170003173 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 930170003174 active site 930170003175 metal binding site [ion binding]; metal-binding site 930170003176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170003177 Walker B; other site 930170003178 D-loop; other site 930170003179 H-loop/switch region; other site 930170003180 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 930170003181 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 930170003182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170003183 putative substrate translocation pore; other site 930170003184 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 930170003185 PAS domain; Region: PAS; smart00091 930170003186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170003187 ATP binding site [chemical binding]; other site 930170003188 Mg2+ binding site [ion binding]; other site 930170003189 G-X-G motif; other site 930170003190 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 930170003191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170003192 active site 930170003193 phosphorylation site [posttranslational modification] 930170003194 intermolecular recognition site; other site 930170003195 dimerization interface [polypeptide binding]; other site 930170003196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 930170003197 Restriction endonuclease; Region: Mrr_cat; pfam04471 930170003198 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 930170003199 Part of AAA domain; Region: AAA_19; pfam13245 930170003200 Family description; Region: UvrD_C_2; pfam13538 930170003201 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 930170003202 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 930170003203 putative metal binding site [ion binding]; other site 930170003204 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 930170003205 putative metal binding site [ion binding]; other site 930170003206 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 930170003207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930170003208 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 930170003209 Protein of unknown function (DUF524); Region: DUF524; pfam04411 930170003210 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 930170003211 homodimer interface [polypeptide binding]; other site 930170003212 chemical substrate binding site [chemical binding]; other site 930170003213 oligomer interface [polypeptide binding]; other site 930170003214 metal binding site [ion binding]; metal-binding site 930170003215 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 930170003216 GIY-YIG motif/motif A; other site 930170003217 putative active site [active] 930170003218 putative metal binding site [ion binding]; other site 930170003219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170003220 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 930170003221 Walker A motif; other site 930170003222 ATP binding site [chemical binding]; other site 930170003223 Walker B motif; other site 930170003224 Uncharacterized conserved protein [Function unknown]; Region: COG3410 930170003225 Tic20-like protein; Region: Tic20; pfam09685 930170003226 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 930170003227 DNA binding residues [nucleotide binding] 930170003228 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170003229 dimer interface [polypeptide binding]; other site 930170003230 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 930170003231 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930170003232 replicative DNA helicase; Provisional; Region: PRK06749 930170003233 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 930170003234 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 930170003235 Walker A motif; other site 930170003236 ATP binding site [chemical binding]; other site 930170003237 Walker B motif; other site 930170003238 DNA binding loops [nucleotide binding] 930170003239 Predicted transcriptional regulators [Transcription]; Region: COG1378 930170003240 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 930170003241 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 930170003242 C-terminal domain interface [polypeptide binding]; other site 930170003243 sugar binding site [chemical binding]; other site 930170003244 hypothetical protein; Provisional; Region: PRK10621 930170003245 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170003246 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170003247 EamA-like transporter family; Region: EamA; pfam00892 930170003248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170003249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170003251 putative substrate translocation pore; other site 930170003252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170003253 Predicted permease; Region: DUF318; cl17795 930170003254 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170003255 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170003256 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 930170003257 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 930170003258 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 930170003259 putative NAD(P) binding site [chemical binding]; other site 930170003260 active site 930170003261 putative substrate binding site [chemical binding]; other site 930170003262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170003263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170003264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170003265 YmzC-like protein; Region: YmzC; pfam14157 930170003266 transcriptional antiterminator BglG; Provisional; Region: PRK09772 930170003267 CAT RNA binding domain; Region: CAT_RBD; smart01061 930170003268 PRD domain; Region: PRD; pfam00874 930170003269 PRD domain; Region: PRD; pfam00874 930170003270 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 930170003271 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170003272 active site turn [active] 930170003273 phosphorylation site [posttranslational modification] 930170003274 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170003275 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 930170003276 HPr interaction site; other site 930170003277 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930170003278 active site 930170003279 phosphorylation site [posttranslational modification] 930170003280 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930170003281 beta-galactosidase; Region: BGL; TIGR03356 930170003282 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930170003283 MarR family; Region: MarR_2; pfam12802 930170003284 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 930170003285 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 930170003286 ATP synthase I chain; Region: ATP_synt_I; pfam03899 930170003287 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 930170003288 VanZ like family; Region: VanZ; pfam04892 930170003289 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 930170003290 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930170003291 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 930170003292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170003293 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 930170003294 dihydroxyacetone kinase; Provisional; Region: PRK14479 930170003295 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 930170003296 DAK2 domain; Region: Dak2; pfam02734 930170003297 CAAX protease self-immunity; Region: Abi; pfam02517 930170003298 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170003299 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170003300 S-layer homology domain; Region: SLH; pfam00395 930170003301 S-layer homology domain; Region: SLH; pfam00395 930170003302 S-layer homology domain; Region: SLH; pfam00395 930170003303 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930170003304 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 930170003305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170003306 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930170003307 active site 930170003308 Heat induced stress protein YflT; Region: YflT; pfam11181 930170003309 CsbD-like; Region: CsbD; pfam05532 930170003310 Predicted membrane protein [Function unknown]; Region: COG2261 930170003311 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 930170003312 anti sigma factor interaction site; other site 930170003313 regulatory phosphorylation site [posttranslational modification]; other site 930170003314 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 930170003315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170003316 ATP binding site [chemical binding]; other site 930170003317 Mg2+ binding site [ion binding]; other site 930170003318 G-X-G motif; other site 930170003319 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 930170003320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170003321 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930170003322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170003323 DNA binding residues [nucleotide binding] 930170003324 Ferritin-like domain; Region: Ferritin; pfam00210 930170003325 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 930170003326 dinuclear metal binding motif [ion binding]; other site 930170003327 Response regulator receiver domain; Region: Response_reg; pfam00072 930170003328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170003329 active site 930170003330 phosphorylation site [posttranslational modification] 930170003331 intermolecular recognition site; other site 930170003332 dimerization interface [polypeptide binding]; other site 930170003333 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 930170003334 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 930170003335 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 930170003336 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 930170003337 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 930170003338 CHASE3 domain; Region: CHASE3; pfam05227 930170003339 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930170003340 GAF domain; Region: GAF; pfam01590 930170003341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170003342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170003343 dimer interface [polypeptide binding]; other site 930170003344 phosphorylation site [posttranslational modification] 930170003345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170003346 ATP binding site [chemical binding]; other site 930170003347 Mg2+ binding site [ion binding]; other site 930170003348 G-X-G motif; other site 930170003349 Response regulator receiver domain; Region: Response_reg; pfam00072 930170003350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170003351 active site 930170003352 phosphorylation site [posttranslational modification] 930170003353 intermolecular recognition site; other site 930170003354 dimerization interface [polypeptide binding]; other site 930170003355 regulatory protein interface [polypeptide binding]; other site 930170003356 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 930170003357 regulatory phosphorylation site [posttranslational modification]; other site 930170003358 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 930170003359 hypothetical protein; Provisional; Region: PRK12856 930170003360 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 930170003361 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 930170003362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930170003363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170003364 catalytic residue [active] 930170003365 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930170003366 active site 930170003367 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 930170003368 active site 2 [active] 930170003369 active site 1 [active] 930170003370 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 930170003371 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930170003372 dimer interface [polypeptide binding]; other site 930170003373 active site 930170003374 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 930170003375 AMP-binding enzyme; Region: AMP-binding; pfam00501 930170003376 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170003377 acyl-activating enzyme (AAE) consensus motif; other site 930170003378 active site 930170003379 AMP binding site [chemical binding]; other site 930170003380 CoA binding site [chemical binding]; other site 930170003381 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 930170003382 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 930170003383 dimer interface [polypeptide binding]; other site 930170003384 FMN binding site [chemical binding]; other site 930170003385 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170003386 EamA-like transporter family; Region: EamA; pfam00892 930170003387 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930170003388 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 930170003389 NADP binding site [chemical binding]; other site 930170003390 dimer interface [polypeptide binding]; other site 930170003391 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 930170003392 YhzD-like protein; Region: YhzD; pfam14120 930170003393 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930170003394 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170003395 active site 930170003396 metal binding site [ion binding]; metal-binding site 930170003397 DNA binding site [nucleotide binding] 930170003398 AAA domain; Region: AAA_27; pfam13514 930170003399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170003400 Q-loop/lid; other site 930170003401 ABC transporter signature motif; other site 930170003402 Walker B; other site 930170003403 D-loop; other site 930170003404 H-loop/switch region; other site 930170003405 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 930170003406 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 930170003407 generic binding surface I; other site 930170003408 generic binding surface II; other site 930170003409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170003410 Zn2+ binding site [ion binding]; other site 930170003411 Mg2+ binding site [ion binding]; other site 930170003412 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 930170003413 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930170003414 Int/Topo IB signature motif; other site 930170003415 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 930170003416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170003417 non-specific DNA binding site [nucleotide binding]; other site 930170003418 salt bridge; other site 930170003419 sequence-specific DNA binding site [nucleotide binding]; other site 930170003420 Domain of unknown function (DUF771); Region: DUF771; cl09962 930170003421 ORF6N domain; Region: ORF6N; pfam10543 930170003422 ORF6C domain; Region: ORF6C; pfam10552 930170003423 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 930170003424 ERF superfamily; Region: ERF; pfam04404 930170003425 Helix-turn-helix domain; Region: HTH_36; pfam13730 930170003426 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 930170003427 hypothetical protein; Provisional; Region: PRK06921 930170003428 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 930170003429 Terminase small subunit; Region: Terminase_2; pfam03592 930170003430 Phage terminase large subunit; Region: Terminase_3; cl12054 930170003431 Terminase-like family; Region: Terminase_6; pfam03237 930170003432 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 930170003433 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 930170003434 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 930170003435 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 930170003436 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 930170003437 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 930170003438 Protein of unknown function (DUF935); Region: DUF935; pfam06074 930170003439 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 930170003440 Phage tail protein; Region: Sipho_tail; pfam05709 930170003441 Phage tail protein; Region: Sipho_tail; cl17486 930170003442 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 930170003443 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930170003444 Holin family; Region: Phage_holin_4; cl01989 930170003445 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170003446 amidase catalytic site [active] 930170003447 Zn binding residues [ion binding]; other site 930170003448 substrate binding site [chemical binding]; other site 930170003449 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 930170003450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930170003451 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930170003452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170003453 Zn binding site [ion binding]; other site 930170003454 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930170003455 Zn binding site [ion binding]; other site 930170003456 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930170003457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170003458 Zn binding site [ion binding]; other site 930170003459 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930170003460 Zn binding site [ion binding]; other site 930170003461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170003462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170003463 TPR motif; other site 930170003464 binding surface 930170003465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170003466 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930170003467 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 930170003468 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 930170003469 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 930170003470 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 930170003471 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 930170003472 amphipathic channel; other site 930170003473 Asn-Pro-Ala signature motifs; other site 930170003474 glycerol kinase; Provisional; Region: glpK; PRK00047 930170003475 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 930170003476 N- and C-terminal domain interface [polypeptide binding]; other site 930170003477 active site 930170003478 MgATP binding site [chemical binding]; other site 930170003479 catalytic site [active] 930170003480 metal binding site [ion binding]; metal-binding site 930170003481 glycerol binding site [chemical binding]; other site 930170003482 homotetramer interface [polypeptide binding]; other site 930170003483 homodimer interface [polypeptide binding]; other site 930170003484 FBP binding site [chemical binding]; other site 930170003485 protein IIAGlc interface [polypeptide binding]; other site 930170003486 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 930170003487 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 930170003488 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 930170003489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170003490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170003491 DNA binding residues [nucleotide binding] 930170003492 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 930170003493 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170003494 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930170003495 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 930170003496 Part of AAA domain; Region: AAA_19; pfam13245 930170003497 Family description; Region: UvrD_C_2; pfam13538 930170003498 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 930170003499 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930170003500 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 930170003501 transcriptional regulator Hpr; Provisional; Region: PRK13777 930170003502 MarR family; Region: MarR; pfam01047 930170003503 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 930170003504 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 930170003505 HIT family signature motif; other site 930170003506 catalytic residue [active] 930170003507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930170003508 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170003509 Walker A/P-loop; other site 930170003510 ATP binding site [chemical binding]; other site 930170003511 Q-loop/lid; other site 930170003512 ABC transporter signature motif; other site 930170003513 Walker B; other site 930170003514 D-loop; other site 930170003515 H-loop/switch region; other site 930170003516 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 930170003517 EcsC protein family; Region: EcsC; pfam12787 930170003518 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 930170003519 nucleophilic elbow; other site 930170003520 catalytic triad; other site 930170003521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170003522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170003523 Uncharacterized conserved protein [Function unknown]; Region: COG3402 930170003524 Predicted membrane protein [Function unknown]; Region: COG3428 930170003525 Bacterial PH domain; Region: DUF304; pfam03703 930170003526 Bacterial PH domain; Region: DUF304; cl01348 930170003527 Bacterial PH domain; Region: DUF304; pfam03703 930170003528 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 930170003529 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 930170003530 SpaB C-terminal domain; Region: SpaB_C; pfam14028 930170003531 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 930170003532 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033 930170003533 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930170003534 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170003535 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 930170003536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170003538 Walker A/P-loop; other site 930170003539 ATP binding site [chemical binding]; other site 930170003540 Q-loop/lid; other site 930170003541 ABC transporter signature motif; other site 930170003542 Walker B; other site 930170003543 D-loop; other site 930170003544 H-loop/switch region; other site 930170003545 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 930170003546 active site 930170003547 zinc binding site [ion binding]; other site 930170003548 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170003549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170003550 non-specific DNA binding site [nucleotide binding]; other site 930170003551 salt bridge; other site 930170003552 sequence-specific DNA binding site [nucleotide binding]; other site 930170003553 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930170003554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170003555 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170003556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170003557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170003558 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170003559 putative substrate translocation pore; other site 930170003560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170003561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170003562 Coenzyme A binding pocket [chemical binding]; other site 930170003563 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 930170003564 S-layer homology domain; Region: SLH; pfam00395 930170003565 S-layer homology domain; Region: SLH; pfam00395 930170003566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 930170003567 carbonic anhydrase; Region: PLN03019 930170003568 Uncharacterized conserved protein [Function unknown]; Region: COG3402 930170003569 Predicted membrane protein [Function unknown]; Region: COG3428 930170003570 Bacterial PH domain; Region: DUF304; pfam03703 930170003571 Bacterial PH domain; Region: DUF304; pfam03703 930170003572 Bacterial PH domain; Region: DUF304; pfam03703 930170003573 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 930170003574 Transglycosylase; Region: Transgly; pfam00912 930170003575 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930170003576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170003577 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 930170003578 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 930170003579 substrate binding site [chemical binding]; other site 930170003580 active site 930170003581 ferrochelatase; Provisional; Region: PRK12435 930170003582 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 930170003583 C-terminal domain interface [polypeptide binding]; other site 930170003584 active site 930170003585 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 930170003586 active site 930170003587 N-terminal domain interface [polypeptide binding]; other site 930170003588 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 930170003589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170003590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170003591 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 930170003592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 930170003593 Fn3 associated; Region: Fn3_assoc; pfam13287 930170003594 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 930170003595 generic binding surface II; other site 930170003596 generic binding surface I; other site 930170003597 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 930170003598 putative active site [active] 930170003599 putative catalytic site [active] 930170003600 putative Mg binding site IVb [ion binding]; other site 930170003601 putative phosphate binding site [ion binding]; other site 930170003602 putative DNA binding site [nucleotide binding]; other site 930170003603 putative Mg binding site IVa [ion binding]; other site 930170003604 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 930170003605 Probable transposase; Region: OrfB_IS605; pfam01385 930170003606 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170003607 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170003608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170003609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170003610 Predicted membrane protein [Function unknown]; Region: COG1511 930170003611 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930170003612 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 930170003613 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 930170003614 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 930170003615 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930170003616 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930170003617 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 930170003618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170003619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170003620 Coenzyme A binding pocket [chemical binding]; other site 930170003621 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170003622 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170003623 DNA binding site [nucleotide binding] 930170003624 domain linker motif; other site 930170003625 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930170003626 putative dimerization interface [polypeptide binding]; other site 930170003627 putative ligand binding site [chemical binding]; other site 930170003628 YhfH-like protein; Region: YhfH; pfam14149 930170003629 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 930170003630 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930170003631 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 930170003632 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 930170003633 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 930170003634 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 930170003635 acyl-activating enzyme (AAE) consensus motif; other site 930170003636 putative AMP binding site [chemical binding]; other site 930170003637 putative active site [active] 930170003638 putative CoA binding site [chemical binding]; other site 930170003639 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 930170003640 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170003641 heme-binding site [chemical binding]; other site 930170003642 S-layer homology domain; Region: SLH; pfam00395 930170003643 S-layer homology domain; Region: SLH; pfam00395 930170003644 S-layer homology domain; Region: SLH; pfam00395 930170003645 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 930170003646 putative RNAase interaction site [polypeptide binding]; other site 930170003647 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930170003648 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930170003649 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170003650 putative active site [active] 930170003651 putative metal binding site [ion binding]; other site 930170003652 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170003653 Zn2+ binding site [ion binding]; other site 930170003654 Mg2+ binding site [ion binding]; other site 930170003655 Putative zinc-finger; Region: zf-HC2; pfam13490 930170003656 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 930170003657 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 930170003658 RNA polymerase sigma factor; Provisional; Region: PRK12541 930170003659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170003660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170003661 DNA binding residues [nucleotide binding] 930170003662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170003663 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170003664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170003665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 930170003666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170003667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170003668 dimer interface [polypeptide binding]; other site 930170003669 phosphorylation site [posttranslational modification] 930170003670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170003671 ATP binding site [chemical binding]; other site 930170003672 Mg2+ binding site [ion binding]; other site 930170003673 G-X-G motif; other site 930170003674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170003675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170003676 active site 930170003677 phosphorylation site [posttranslational modification] 930170003678 intermolecular recognition site; other site 930170003679 dimerization interface [polypeptide binding]; other site 930170003680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170003681 DNA binding site [nucleotide binding] 930170003682 CAAX protease self-immunity; Region: Abi; pfam02517 930170003683 Peptidase family M48; Region: Peptidase_M48; pfam01435 930170003684 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170003685 EamA-like transporter family; Region: EamA; pfam00892 930170003686 EamA-like transporter family; Region: EamA; pfam00892 930170003687 S-layer homology domain; Region: SLH; pfam00395 930170003688 S-layer homology domain; Region: SLH; pfam00395 930170003689 S-layer homology domain; Region: SLH; pfam00395 930170003690 S-layer homology domain; Region: SLH; pfam00395 930170003691 S-layer homology domain; Region: SLH; pfam00395 930170003692 S-layer homology domain; Region: SLH; pfam00395 930170003693 malate synthase A; Region: malate_syn_A; TIGR01344 930170003694 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 930170003695 active site 930170003696 isocitrate lyase; Provisional; Region: PRK15063 930170003697 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 930170003698 tetramer interface [polypeptide binding]; other site 930170003699 active site 930170003700 Mg2+/Mn2+ binding site [ion binding]; other site 930170003701 Phosphotransferase enzyme family; Region: APH; pfam01636 930170003702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930170003703 active site 930170003704 substrate binding site [chemical binding]; other site 930170003705 ATP binding site [chemical binding]; other site 930170003706 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930170003707 DNA-binding site [nucleotide binding]; DNA binding site 930170003708 RNA-binding motif; other site 930170003709 ComK protein; Region: ComK; pfam06338 930170003710 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 930170003711 protein binding site [polypeptide binding]; other site 930170003712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170003713 Histidine kinase; Region: HisKA_3; pfam07730 930170003714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170003715 ATP binding site [chemical binding]; other site 930170003716 Mg2+ binding site [ion binding]; other site 930170003717 G-X-G motif; other site 930170003718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170003719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170003720 active site 930170003721 phosphorylation site [posttranslational modification] 930170003722 intermolecular recognition site; other site 930170003723 dimerization interface [polypeptide binding]; other site 930170003724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170003725 DNA binding residues [nucleotide binding] 930170003726 dimerization interface [polypeptide binding]; other site 930170003727 Uncharacterized conserved protein [Function unknown]; Region: COG0398 930170003728 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170003729 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930170003730 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170003731 Catalytic site [active] 930170003732 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 930170003733 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930170003734 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 930170003735 Part of AAA domain; Region: AAA_19; pfam13245 930170003736 Family description; Region: UvrD_C_2; pfam13538 930170003737 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930170003738 hypothetical protein; Provisional; Region: PRK07758 930170003739 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 930170003740 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 930170003741 Spore germination protein GerPC; Region: GerPC; pfam10737 930170003742 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 930170003743 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 930170003744 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 930170003745 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930170003746 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930170003747 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 930170003748 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170003749 inhibitor-cofactor binding pocket; inhibition site 930170003750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170003751 catalytic residue [active] 930170003752 hypothetical protein; Provisional; Region: PRK13673 930170003753 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 930170003754 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 930170003755 active site 930170003756 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 930170003757 dimer interface [polypeptide binding]; other site 930170003758 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 930170003759 Ligand Binding Site [chemical binding]; other site 930170003760 Molecular Tunnel; other site 930170003761 ferrochelatase; Provisional; Region: PRK12435 930170003762 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 930170003763 C-terminal domain interface [polypeptide binding]; other site 930170003764 active site 930170003765 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 930170003766 active site 930170003767 N-terminal domain interface [polypeptide binding]; other site 930170003768 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 930170003769 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 930170003770 tetramer interface [polypeptide binding]; other site 930170003771 heme binding pocket [chemical binding]; other site 930170003772 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 930170003773 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 930170003774 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930170003775 active site 930170003776 catalytic site [active] 930170003777 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170003778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170003779 non-specific DNA binding site [nucleotide binding]; other site 930170003780 salt bridge; other site 930170003781 sequence-specific DNA binding site [nucleotide binding]; other site 930170003782 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170003783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 930170003784 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 930170003785 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 930170003786 S1 domain; Region: S1_2; pfam13509 930170003787 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 930170003788 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930170003789 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170003790 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170003791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170003792 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170003793 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 930170003794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170003795 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170003796 active site 930170003797 motif I; other site 930170003798 motif II; other site 930170003799 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930170003800 YjzC-like protein; Region: YjzC; pfam14168 930170003801 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 930170003802 Clp amino terminal domain; Region: Clp_N; pfam02861 930170003803 Clp amino terminal domain; Region: Clp_N; pfam02861 930170003804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170003805 Walker A motif; other site 930170003806 ATP binding site [chemical binding]; other site 930170003807 Walker B motif; other site 930170003808 arginine finger; other site 930170003809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170003810 Walker A motif; other site 930170003811 ATP binding site [chemical binding]; other site 930170003812 Walker B motif; other site 930170003813 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 930170003814 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 930170003815 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 930170003816 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 930170003817 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 930170003818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170003819 NAD(P) binding site [chemical binding]; other site 930170003820 active site 930170003821 ComZ; Region: ComZ; pfam10815 930170003822 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 930170003823 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930170003824 dimer interface [polypeptide binding]; other site 930170003825 active site 930170003826 CoA binding pocket [chemical binding]; other site 930170003827 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 930170003828 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930170003829 dimer interface [polypeptide binding]; other site 930170003830 active site 930170003831 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 930170003832 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 930170003833 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 930170003834 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 930170003835 active site 930170003836 HIGH motif; other site 930170003837 dimer interface [polypeptide binding]; other site 930170003838 KMSKS motif; other site 930170003839 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 930170003840 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170003841 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170003842 peptide binding site [polypeptide binding]; other site 930170003843 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170003845 dimer interface [polypeptide binding]; other site 930170003846 conserved gate region; other site 930170003847 putative PBP binding loops; other site 930170003848 ABC-ATPase subunit interface; other site 930170003849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170003850 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930170003851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170003852 dimer interface [polypeptide binding]; other site 930170003853 conserved gate region; other site 930170003854 putative PBP binding loops; other site 930170003855 ABC-ATPase subunit interface; other site 930170003856 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930170003857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170003858 Walker A/P-loop; other site 930170003859 ATP binding site [chemical binding]; other site 930170003860 Q-loop/lid; other site 930170003861 ABC transporter signature motif; other site 930170003862 Walker B; other site 930170003863 D-loop; other site 930170003864 H-loop/switch region; other site 930170003865 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930170003866 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930170003867 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930170003868 Walker A/P-loop; other site 930170003869 ATP binding site [chemical binding]; other site 930170003870 Q-loop/lid; other site 930170003871 ABC transporter signature motif; other site 930170003872 Walker B; other site 930170003873 D-loop; other site 930170003874 H-loop/switch region; other site 930170003875 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930170003876 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930170003877 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 930170003878 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170003879 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170003880 peptide binding site [polypeptide binding]; other site 930170003881 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 930170003882 ArsC family; Region: ArsC; pfam03960 930170003883 putative catalytic residues [active] 930170003884 thiol/disulfide switch; other site 930170003885 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 930170003886 adaptor protein; Provisional; Region: PRK02315 930170003887 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 930170003888 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930170003889 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930170003890 putative active site [active] 930170003891 catalytic site [active] 930170003892 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930170003893 putative active site [active] 930170003894 catalytic site [active] 930170003895 Competence protein CoiA-like family; Region: CoiA; cl11541 930170003896 oligoendopeptidase F; Region: pepF; TIGR00181 930170003897 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 930170003898 active site 930170003899 Zn binding site [ion binding]; other site 930170003900 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 930170003901 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 930170003902 catalytic residues [active] 930170003903 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 930170003904 apolar tunnel; other site 930170003905 heme binding site [chemical binding]; other site 930170003906 dimerization interface [polypeptide binding]; other site 930170003907 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 930170003908 putative active site [active] 930170003909 putative metal binding residues [ion binding]; other site 930170003910 signature motif; other site 930170003911 putative triphosphate binding site [ion binding]; other site 930170003912 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930170003913 synthetase active site [active] 930170003914 NTP binding site [chemical binding]; other site 930170003915 metal binding site [ion binding]; metal-binding site 930170003916 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 930170003917 ATP-NAD kinase; Region: NAD_kinase; pfam01513 930170003918 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930170003919 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930170003920 active site 930170003921 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 930170003922 trimer interface [polypeptide binding]; other site 930170003923 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 930170003924 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 930170003925 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 930170003926 active site 930170003927 metal binding site [ion binding]; metal-binding site 930170003928 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 930170003929 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930170003930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930170003931 active site 930170003932 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170003933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170003934 S-adenosylmethionine binding site [chemical binding]; other site 930170003935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930170003936 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 930170003937 putative metal binding site; other site 930170003938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170003939 binding surface 930170003940 TPR motif; other site 930170003941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930170003942 binding surface 930170003943 TPR motif; other site 930170003944 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170003946 S-adenosylmethionine binding site [chemical binding]; other site 930170003947 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 930170003948 catalytic residues [active] 930170003949 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 930170003950 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 930170003951 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170003952 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930170003953 active site 930170003954 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 930170003955 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 930170003956 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 930170003957 NAD binding site [chemical binding]; other site 930170003958 substrate binding site [chemical binding]; other site 930170003959 homodimer interface [polypeptide binding]; other site 930170003960 active site 930170003961 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 930170003962 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 930170003963 NADP binding site [chemical binding]; other site 930170003964 active site 930170003965 putative substrate binding site [chemical binding]; other site 930170003966 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 930170003967 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 930170003968 NAD binding site [chemical binding]; other site 930170003969 homotetramer interface [polypeptide binding]; other site 930170003970 homodimer interface [polypeptide binding]; other site 930170003971 substrate binding site [chemical binding]; other site 930170003972 active site 930170003973 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 930170003974 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 930170003975 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 930170003976 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 930170003977 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 930170003978 Part of AAA domain; Region: AAA_19; pfam13245 930170003979 Family description; Region: UvrD_C_2; pfam13538 930170003980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 930170003981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170003982 Coenzyme A binding pocket [chemical binding]; other site 930170003983 hypothetical protein; Provisional; Region: PRK13679 930170003984 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 930170003985 Putative esterase; Region: Esterase; pfam00756 930170003986 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 930170003987 EamA-like transporter family; Region: EamA; pfam00892 930170003988 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170003989 EamA-like transporter family; Region: EamA; pfam00892 930170003990 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 930170003991 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 930170003992 Pectate lyase; Region: Pectate_lyase; pfam03211 930170003993 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 930170003994 Na binding site [ion binding]; other site 930170003995 anthranilate synthase component I; Provisional; Region: PRK13570 930170003996 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 930170003997 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930170003998 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 930170003999 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930170004000 glutamine binding [chemical binding]; other site 930170004001 catalytic triad [active] 930170004002 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 930170004003 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930170004004 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930170004005 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 930170004006 active site 930170004007 ribulose/triose binding site [chemical binding]; other site 930170004008 phosphate binding site [ion binding]; other site 930170004009 substrate (anthranilate) binding pocket [chemical binding]; other site 930170004010 product (indole) binding pocket [chemical binding]; other site 930170004011 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 930170004012 active site 930170004013 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 930170004014 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 930170004015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170004016 catalytic residue [active] 930170004017 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 930170004018 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 930170004019 substrate binding site [chemical binding]; other site 930170004020 active site 930170004021 catalytic residues [active] 930170004022 heterodimer interface [polypeptide binding]; other site 930170004023 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 930170004024 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 930170004025 L-lactate permease; Region: Lactate_perm; cl00701 930170004026 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 930170004027 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 930170004028 Double zinc ribbon; Region: DZR; pfam12773 930170004029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170004030 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 930170004031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170004032 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930170004033 Predicted acetyltransferase [General function prediction only]; Region: COG5628 930170004034 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 930170004035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170004036 S-adenosylmethionine binding site [chemical binding]; other site 930170004037 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930170004038 NADPH bind site [chemical binding]; other site 930170004039 putative FMN binding site [chemical binding]; other site 930170004040 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930170004041 putative FMN binding site [chemical binding]; other site 930170004042 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 930170004043 YcaO-like family; Region: YcaO; pfam02624 930170004044 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 930170004045 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 930170004046 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 930170004047 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 930170004048 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930170004049 E3 interaction surface; other site 930170004050 lipoyl attachment site [posttranslational modification]; other site 930170004051 e3 binding domain; Region: E3_binding; pfam02817 930170004052 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930170004053 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 930170004054 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 930170004055 TPP-binding site [chemical binding]; other site 930170004056 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 930170004057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170004058 salt bridge; other site 930170004059 non-specific DNA binding site [nucleotide binding]; other site 930170004060 sequence-specific DNA binding site [nucleotide binding]; other site 930170004061 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 930170004062 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 930170004063 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 930170004064 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 930170004065 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 930170004066 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170004067 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 930170004068 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 930170004069 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170004070 Catalytic site [active] 930170004071 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 930170004072 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 930170004073 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 930170004074 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170004075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170004076 non-specific DNA binding site [nucleotide binding]; other site 930170004077 salt bridge; other site 930170004078 sequence-specific DNA binding site [nucleotide binding]; other site 930170004079 Anti-repressor SinI; Region: SinI; pfam08671 930170004080 Anti-repressor SinI; Region: SinI; pfam08671 930170004081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 930170004082 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 930170004083 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 930170004084 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 930170004085 NAD(P) binding site [chemical binding]; other site 930170004086 catalytic residues [active] 930170004087 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930170004088 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 930170004089 Walker A/P-loop; other site 930170004090 ATP binding site [chemical binding]; other site 930170004091 Q-loop/lid; other site 930170004092 ABC transporter signature motif; other site 930170004093 Walker B; other site 930170004094 D-loop; other site 930170004095 H-loop/switch region; other site 930170004096 TOBE domain; Region: TOBE_2; pfam08402 930170004097 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 930170004098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170004099 dimer interface [polypeptide binding]; other site 930170004100 conserved gate region; other site 930170004101 putative PBP binding loops; other site 930170004102 ABC-ATPase subunit interface; other site 930170004103 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930170004104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170004105 dimer interface [polypeptide binding]; other site 930170004106 conserved gate region; other site 930170004107 putative PBP binding loops; other site 930170004108 ABC-ATPase subunit interface; other site 930170004109 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 930170004110 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 930170004111 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930170004112 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930170004113 active site 930170004114 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 930170004115 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 930170004116 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930170004117 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930170004118 active site 930170004119 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930170004120 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 930170004121 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 930170004122 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 930170004123 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 930170004124 Cysteine-rich domain; Region: CCG; pfam02754 930170004125 Cysteine-rich domain; Region: CCG; pfam02754 930170004126 FAD binding domain; Region: FAD_binding_4; pfam01565 930170004127 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 930170004128 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 930170004129 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 930170004130 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930170004131 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 930170004132 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 930170004133 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 930170004134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170004135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170004136 active site 930170004137 phosphorylation site [posttranslational modification] 930170004138 intermolecular recognition site; other site 930170004139 dimerization interface [polypeptide binding]; other site 930170004140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170004141 DNA binding site [nucleotide binding] 930170004142 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930170004143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170004144 dimerization interface [polypeptide binding]; other site 930170004145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170004146 dimer interface [polypeptide binding]; other site 930170004147 phosphorylation site [posttranslational modification] 930170004148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004149 ATP binding site [chemical binding]; other site 930170004150 Mg2+ binding site [ion binding]; other site 930170004151 G-X-G motif; other site 930170004152 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930170004153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170004154 DNA-binding site [nucleotide binding]; DNA binding site 930170004155 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 930170004156 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 930170004157 Cysteine-rich domain; Region: CCG; pfam02754 930170004158 Cysteine-rich domain; Region: CCG; pfam02754 930170004159 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 930170004160 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 930170004161 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 930170004162 Uncharacterized conserved protein [Function unknown]; Region: COG1556 930170004163 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 930170004164 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 930170004165 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 930170004166 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 930170004167 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 930170004168 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930170004169 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930170004170 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170004171 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 930170004172 dimer interaction site [polypeptide binding]; other site 930170004173 substrate-binding tunnel; other site 930170004174 active site 930170004175 catalytic site [active] 930170004176 substrate binding site [chemical binding]; other site 930170004177 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 930170004178 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 930170004179 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170004180 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 930170004181 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 930170004182 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 930170004183 NAD(P) binding site [chemical binding]; other site 930170004184 homotetramer interface [polypeptide binding]; other site 930170004185 homodimer interface [polypeptide binding]; other site 930170004186 active site 930170004187 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 930170004188 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 930170004189 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 930170004190 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 930170004191 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930170004192 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930170004193 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930170004194 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 930170004195 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 930170004196 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 930170004197 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 930170004198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170004199 Walker A/P-loop; other site 930170004200 ATP binding site [chemical binding]; other site 930170004201 Q-loop/lid; other site 930170004202 ABC transporter signature motif; other site 930170004203 Walker B; other site 930170004204 D-loop; other site 930170004205 H-loop/switch region; other site 930170004206 TOBE domain; Region: TOBE_2; pfam08402 930170004207 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 930170004208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170004209 dimer interface [polypeptide binding]; other site 930170004210 conserved gate region; other site 930170004211 putative PBP binding loops; other site 930170004212 ABC-ATPase subunit interface; other site 930170004213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170004214 dimer interface [polypeptide binding]; other site 930170004215 conserved gate region; other site 930170004216 putative PBP binding loops; other site 930170004217 ABC-ATPase subunit interface; other site 930170004218 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 930170004219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170004220 motif II; other site 930170004221 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 930170004222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170004223 catalytic residue [active] 930170004224 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 930170004225 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930170004226 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 930170004227 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930170004228 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170004229 heme-binding site [chemical binding]; other site 930170004230 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930170004231 Leucine-rich repeats; other site 930170004232 Substrate binding site [chemical binding]; other site 930170004233 Leucine rich repeat; Region: LRR_8; pfam13855 930170004234 Leucine rich repeat; Region: LRR_8; pfam13855 930170004235 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170004236 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170004237 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170004238 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930170004239 S-layer homology domain; Region: SLH; pfam00395 930170004240 S-layer homology domain; Region: SLH; pfam00395 930170004241 S-layer homology domain; Region: SLH; pfam00395 930170004242 hypothetical protein; Validated; Region: PRK06755 930170004243 intersubunit interface [polypeptide binding]; other site 930170004244 active site 930170004245 Zn2+ binding site [ion binding]; other site 930170004246 FOG: CBS domain [General function prediction only]; Region: COG0517 930170004247 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 930170004248 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 930170004249 NodB motif; other site 930170004250 putative active site [active] 930170004251 putative catalytic site [active] 930170004252 Zn binding site [ion binding]; other site 930170004253 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 930170004254 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 930170004255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170004256 dimer interface [polypeptide binding]; other site 930170004257 phosphorylation site [posttranslational modification] 930170004258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004259 ATP binding site [chemical binding]; other site 930170004260 Mg2+ binding site [ion binding]; other site 930170004261 G-X-G motif; other site 930170004262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170004263 MarR family; Region: MarR; pfam01047 930170004264 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 930170004265 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 930170004266 active site 930170004267 Zn binding site [ion binding]; other site 930170004268 DinB superfamily; Region: DinB_2; pfam12867 930170004269 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930170004270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170004271 dimer interface [polypeptide binding]; other site 930170004272 phosphorylation site [posttranslational modification] 930170004273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004274 ATP binding site [chemical binding]; other site 930170004275 Mg2+ binding site [ion binding]; other site 930170004276 G-X-G motif; other site 930170004277 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 930170004278 Ligand Binding Site [chemical binding]; other site 930170004279 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 930170004280 active site 930170004281 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 930170004282 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 930170004283 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 930170004284 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 930170004285 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 930170004286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170004287 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170004288 Coenzyme A binding pocket [chemical binding]; other site 930170004289 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 930170004290 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 930170004291 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 930170004292 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 930170004293 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 930170004294 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 930170004295 dimer interface [polypeptide binding]; other site 930170004296 putative radical transfer pathway; other site 930170004297 diiron center [ion binding]; other site 930170004298 tyrosyl radical; other site 930170004299 Predicted transcriptional regulators [Transcription]; Region: COG1725 930170004300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170004301 DNA-binding site [nucleotide binding]; DNA binding site 930170004302 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170004303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170004304 Walker A/P-loop; other site 930170004305 ATP binding site [chemical binding]; other site 930170004306 Q-loop/lid; other site 930170004307 ABC transporter signature motif; other site 930170004308 Walker B; other site 930170004309 D-loop; other site 930170004310 H-loop/switch region; other site 930170004311 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170004312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170004313 Walker A/P-loop; other site 930170004314 ATP binding site [chemical binding]; other site 930170004315 Q-loop/lid; other site 930170004316 ABC transporter signature motif; other site 930170004317 Walker B; other site 930170004318 D-loop; other site 930170004319 H-loop/switch region; other site 930170004320 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930170004321 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170004322 CAAX protease self-immunity; Region: Abi; pfam02517 930170004323 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930170004324 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 930170004325 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930170004326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170004327 putative DNA binding site [nucleotide binding]; other site 930170004328 putative Zn2+ binding site [ion binding]; other site 930170004329 AsnC family; Region: AsnC_trans_reg; pfam01037 930170004330 Uncharacterized conserved protein [Function unknown]; Region: COG2128 930170004331 SseB protein; Region: SseB; cl06279 930170004332 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 930170004333 dimer interface [polypeptide binding]; other site 930170004334 catalytic triad [active] 930170004335 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 930170004336 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 930170004337 FMN binding site [chemical binding]; other site 930170004338 substrate binding site [chemical binding]; other site 930170004339 putative catalytic residue [active] 930170004340 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 930170004341 DltD N-terminal region; Region: DltD_N; pfam04915 930170004342 DltD central region; Region: DltD_M; pfam04918 930170004343 DltD C-terminal region; Region: DltD_C; pfam04914 930170004344 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 930170004345 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 930170004346 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 930170004347 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 930170004348 acyl-activating enzyme (AAE) consensus motif; other site 930170004349 AMP binding site [chemical binding]; other site 930170004350 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 930170004351 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930170004352 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930170004353 metal binding site [ion binding]; metal-binding site 930170004354 dimer interface [polypeptide binding]; other site 930170004355 flavodoxin; Provisional; Region: PRK06756 930170004356 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 930170004357 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 930170004358 Phosphotransferase enzyme family; Region: APH; pfam01636 930170004359 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170004360 active site 930170004361 substrate binding site [chemical binding]; other site 930170004362 ATP binding site [chemical binding]; other site 930170004363 multidrug efflux protein; Reviewed; Region: PRK01766 930170004364 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 930170004365 cation binding site [ion binding]; other site 930170004366 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 930170004367 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170004368 catalytic residues [active] 930170004369 Regulatory protein YrvL; Region: YrvL; pfam14184 930170004370 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170004371 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 930170004372 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930170004373 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 930170004374 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930170004375 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930170004376 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 930170004377 hypothetical protein; Provisional; Region: PRK03094 930170004378 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 930170004379 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930170004380 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 930170004381 homodimer interface [polypeptide binding]; other site 930170004382 substrate-cofactor binding pocket; other site 930170004383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170004384 catalytic residue [active] 930170004385 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 930170004386 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930170004387 PYR/PP interface [polypeptide binding]; other site 930170004388 dimer interface [polypeptide binding]; other site 930170004389 TPP binding site [chemical binding]; other site 930170004390 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170004391 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 930170004392 TPP-binding site [chemical binding]; other site 930170004393 dimer interface [polypeptide binding]; other site 930170004394 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 930170004395 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 930170004396 putative valine binding site [chemical binding]; other site 930170004397 dimer interface [polypeptide binding]; other site 930170004398 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 930170004399 ketol-acid reductoisomerase; Provisional; Region: PRK05479 930170004400 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 930170004401 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 930170004402 2-isopropylmalate synthase; Validated; Region: PRK00915 930170004403 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 930170004404 active site 930170004405 catalytic residues [active] 930170004406 metal binding site [ion binding]; metal-binding site 930170004407 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 930170004408 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 930170004409 tartrate dehydrogenase; Region: TTC; TIGR02089 930170004410 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 930170004411 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 930170004412 substrate binding site [chemical binding]; other site 930170004413 ligand binding site [chemical binding]; other site 930170004414 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 930170004415 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 930170004416 substrate binding site [chemical binding]; other site 930170004417 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 930170004418 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930170004419 dimer interface [polypeptide binding]; other site 930170004420 motif 1; other site 930170004421 active site 930170004422 motif 2; other site 930170004423 motif 3; other site 930170004424 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 930170004425 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 930170004426 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 930170004427 histidinol dehydrogenase; Region: hisD; TIGR00069 930170004428 NAD binding site [chemical binding]; other site 930170004429 dimerization interface [polypeptide binding]; other site 930170004430 product binding site; other site 930170004431 substrate binding site [chemical binding]; other site 930170004432 zinc binding site [ion binding]; other site 930170004433 catalytic residues [active] 930170004434 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 930170004435 putative active site pocket [active] 930170004436 4-fold oligomerization interface [polypeptide binding]; other site 930170004437 metal binding residues [ion binding]; metal-binding site 930170004438 3-fold/trimer interface [polypeptide binding]; other site 930170004439 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 930170004440 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 930170004441 putative active site [active] 930170004442 oxyanion strand; other site 930170004443 catalytic triad [active] 930170004444 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 930170004445 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 930170004446 catalytic residues [active] 930170004447 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 930170004448 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 930170004449 substrate binding site [chemical binding]; other site 930170004450 glutamase interaction surface [polypeptide binding]; other site 930170004451 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 930170004452 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 930170004453 metal binding site [ion binding]; metal-binding site 930170004454 histidinol-phosphatase; Validated; Region: PRK06740 930170004455 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 930170004456 dimer interface [polypeptide binding]; other site 930170004457 active site 930170004458 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 930170004459 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 930170004460 putative ligand binding site [chemical binding]; other site 930170004461 putative NAD binding site [chemical binding]; other site 930170004462 catalytic site [active] 930170004463 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 930170004464 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 930170004465 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930170004466 Sulfatase; Region: Sulfatase; pfam00884 930170004467 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 930170004468 diaminopimelate decarboxylase; Region: lysA; TIGR01048 930170004469 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 930170004470 active site 930170004471 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930170004472 substrate binding site [chemical binding]; other site 930170004473 catalytic residues [active] 930170004474 dimer interface [polypeptide binding]; other site 930170004475 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 930170004476 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 930170004477 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 930170004478 Active Sites [active] 930170004479 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 930170004480 ATP-sulfurylase; Region: ATPS; cd00517 930170004481 active site 930170004482 HXXH motif; other site 930170004483 flexible loop; other site 930170004484 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 930170004485 AAA domain; Region: AAA_18; pfam13238 930170004486 ligand-binding site [chemical binding]; other site 930170004487 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 930170004488 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930170004489 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930170004490 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 930170004491 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 930170004492 diphthine synthase; Region: dph5; TIGR00522 930170004493 active site 930170004494 SAM binding site [chemical binding]; other site 930170004495 homodimer interface [polypeptide binding]; other site 930170004496 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 930170004497 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 930170004498 putative active site [active] 930170004499 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 930170004500 putative active site [active] 930170004501 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 930170004502 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 930170004503 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 930170004504 Na2 binding site [ion binding]; other site 930170004505 putative substrate binding site 1 [chemical binding]; other site 930170004506 Na binding site 1 [ion binding]; other site 930170004507 putative substrate binding site 2 [chemical binding]; other site 930170004508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 930170004509 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170004510 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170004511 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930170004512 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 930170004513 Protein of unknown function (DUF402); Region: DUF402; cl00979 930170004514 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 930170004515 Vpu protein; Region: Vpu; pfam00558 930170004516 PspA/IM30 family; Region: PspA_IM30; pfam04012 930170004517 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 930170004518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170004519 Histidine kinase; Region: HisKA_3; pfam07730 930170004520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004521 ATP binding site [chemical binding]; other site 930170004522 Mg2+ binding site [ion binding]; other site 930170004523 G-X-G motif; other site 930170004524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170004525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170004526 active site 930170004527 phosphorylation site [posttranslational modification] 930170004528 intermolecular recognition site; other site 930170004529 dimerization interface [polypeptide binding]; other site 930170004530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170004531 DNA binding residues [nucleotide binding] 930170004532 dimerization interface [polypeptide binding]; other site 930170004533 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930170004534 E3 interaction surface; other site 930170004535 lipoyl attachment site [posttranslational modification]; other site 930170004536 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 930170004537 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170004538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170004539 S-adenosylmethionine binding site [chemical binding]; other site 930170004540 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 930170004541 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 930170004542 heme-binding site [chemical binding]; other site 930170004543 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 930170004544 FAD binding pocket [chemical binding]; other site 930170004545 FAD binding motif [chemical binding]; other site 930170004546 phosphate binding motif [ion binding]; other site 930170004547 beta-alpha-beta structure motif; other site 930170004548 NAD binding pocket [chemical binding]; other site 930170004549 Heme binding pocket [chemical binding]; other site 930170004550 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930170004551 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930170004552 ligand binding site [chemical binding]; other site 930170004553 flexible hinge region; other site 930170004554 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 930170004555 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170004556 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930170004557 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 930170004558 Transglycosylase; Region: Transgly; pfam00912 930170004559 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930170004560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170004561 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 930170004562 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 930170004563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170004564 putative active site [active] 930170004565 heme pocket [chemical binding]; other site 930170004566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170004567 dimer interface [polypeptide binding]; other site 930170004568 phosphorylation site [posttranslational modification] 930170004569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004570 ATP binding site [chemical binding]; other site 930170004571 Mg2+ binding site [ion binding]; other site 930170004572 G-X-G motif; other site 930170004573 Protein of unknown function DUF72; Region: DUF72; pfam01904 930170004574 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 930170004575 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170004576 active site 930170004577 DNA binding site [nucleotide binding] 930170004578 Int/Topo IB signature motif; other site 930170004579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170004580 dimerization interface [polypeptide binding]; other site 930170004581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170004582 dimer interface [polypeptide binding]; other site 930170004583 phosphorylation site [posttranslational modification] 930170004584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004585 ATP binding site [chemical binding]; other site 930170004586 Mg2+ binding site [ion binding]; other site 930170004587 G-X-G motif; other site 930170004588 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 930170004589 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 930170004590 Predicted integral membrane protein [Function unknown]; Region: COG0392 930170004591 Uncharacterized conserved protein [Function unknown]; Region: COG2898 930170004592 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 930170004593 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 930170004594 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 930170004595 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 930170004596 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 930170004597 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 930170004598 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170004599 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 930170004600 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 930170004601 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 930170004602 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930170004603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170004604 RNA binding surface [nucleotide binding]; other site 930170004605 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 930170004606 active site 930170004607 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 930170004608 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930170004609 catalytic residues [active] 930170004610 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 930170004611 ResB-like family; Region: ResB; pfam05140 930170004612 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 930170004613 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 930170004614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170004615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170004616 active site 930170004617 phosphorylation site [posttranslational modification] 930170004618 intermolecular recognition site; other site 930170004619 dimerization interface [polypeptide binding]; other site 930170004620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170004621 DNA binding site [nucleotide binding] 930170004622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 930170004623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170004624 dimerization interface [polypeptide binding]; other site 930170004625 PAS domain; Region: PAS; smart00091 930170004626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170004627 dimer interface [polypeptide binding]; other site 930170004628 phosphorylation site [posttranslational modification] 930170004629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170004630 ATP binding site [chemical binding]; other site 930170004631 Mg2+ binding site [ion binding]; other site 930170004632 G-X-G motif; other site 930170004633 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 930170004634 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170004635 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170004636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170004637 Predicted membrane protein [Function unknown]; Region: COG3601 930170004638 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930170004639 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 930170004640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 930170004641 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930170004642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170004643 ATP binding site [chemical binding]; other site 930170004644 putative Mg++ binding site [ion binding]; other site 930170004645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170004646 nucleotide binding region [chemical binding]; other site 930170004647 ATP-binding site [chemical binding]; other site 930170004648 CAAX protease self-immunity; Region: Abi; pfam02517 930170004649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170004650 phosphodiesterase YaeI; Provisional; Region: PRK11340 930170004651 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930170004652 putative active site [active] 930170004653 putative metal binding site [ion binding]; other site 930170004654 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170004655 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 930170004656 DNA binding residues [nucleotide binding] 930170004657 B12 binding domain; Region: B12-binding_2; pfam02607 930170004658 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 930170004659 adaptor protein; Provisional; Region: PRK02899 930170004660 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 930170004661 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 930170004662 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 930170004663 NAD(P) binding site [chemical binding]; other site 930170004664 Tetrahydromethanopterin S-methyltransferase, subunit E; Region: MtrE; cl01675 930170004665 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 930170004666 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170004667 amidase catalytic site [active] 930170004668 Zn binding residues [ion binding]; other site 930170004669 substrate binding site [chemical binding]; other site 930170004670 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 930170004671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 930170004672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170004673 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 930170004674 active site 930170004675 homotetramer interface [polypeptide binding]; other site 930170004676 homodimer interface [polypeptide binding]; other site 930170004677 cytidylate kinase; Provisional; Region: cmk; PRK00023 930170004678 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 930170004679 CMP-binding site; other site 930170004680 The sites determining sugar specificity; other site 930170004681 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 930170004682 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 930170004683 RNA binding site [nucleotide binding]; other site 930170004684 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 930170004685 RNA binding site [nucleotide binding]; other site 930170004686 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 930170004687 RNA binding site [nucleotide binding]; other site 930170004688 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930170004689 RNA binding site [nucleotide binding]; other site 930170004690 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 930170004691 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 930170004692 homotetramer interface [polypeptide binding]; other site 930170004693 FMN binding site [chemical binding]; other site 930170004694 homodimer contacts [polypeptide binding]; other site 930170004695 putative active site [active] 930170004696 putative substrate binding site [chemical binding]; other site 930170004697 YpzI-like protein; Region: YpzI; pfam14140 930170004698 YIEGIA protein; Region: YIEGIA; pfam14045 930170004699 GTP-binding protein Der; Reviewed; Region: PRK00093 930170004700 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 930170004701 G1 box; other site 930170004702 GTP/Mg2+ binding site [chemical binding]; other site 930170004703 Switch I region; other site 930170004704 G2 box; other site 930170004705 Switch II region; other site 930170004706 G3 box; other site 930170004707 G4 box; other site 930170004708 G5 box; other site 930170004709 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 930170004710 G1 box; other site 930170004711 GTP/Mg2+ binding site [chemical binding]; other site 930170004712 Switch I region; other site 930170004713 G2 box; other site 930170004714 G3 box; other site 930170004715 Switch II region; other site 930170004716 G4 box; other site 930170004717 G5 box; other site 930170004718 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 930170004719 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 930170004720 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 930170004721 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 930170004722 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 930170004723 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 930170004724 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 930170004725 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 930170004726 IHF dimer interface [polypeptide binding]; other site 930170004727 IHF - DNA interface [nucleotide binding]; other site 930170004728 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 930170004729 homodecamer interface [polypeptide binding]; other site 930170004730 GTP cyclohydrolase I; Provisional; Region: PLN03044 930170004731 active site 930170004732 putative catalytic site residues [active] 930170004733 zinc binding site [ion binding]; other site 930170004734 GTP-CH-I/GFRP interaction surface; other site 930170004735 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 930170004736 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 930170004737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170004738 S-adenosylmethionine binding site [chemical binding]; other site 930170004739 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930170004740 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930170004741 substrate binding pocket [chemical binding]; other site 930170004742 chain length determination region; other site 930170004743 substrate-Mg2+ binding site; other site 930170004744 catalytic residues [active] 930170004745 aspartate-rich region 1; other site 930170004746 active site lid residues [active] 930170004747 aspartate-rich region 2; other site 930170004748 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 930170004749 active site 930170004750 multimer interface [polypeptide binding]; other site 930170004751 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 930170004752 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 930170004753 Tetramer interface [polypeptide binding]; other site 930170004754 active site 930170004755 FMN-binding site [chemical binding]; other site 930170004756 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 930170004757 active site 930170004758 dimer interface [polypeptide binding]; other site 930170004759 metal binding site [ion binding]; metal-binding site 930170004760 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 930170004761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170004762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170004763 homodimer interface [polypeptide binding]; other site 930170004764 catalytic residue [active] 930170004765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170004766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170004767 binding surface 930170004768 TPR motif; other site 930170004769 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 930170004770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170004771 binding surface 930170004772 TPR motif; other site 930170004773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170004774 TPR repeat; Region: TPR_11; pfam13414 930170004775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170004776 binding surface 930170004777 TPR motif; other site 930170004778 hypothetical protein; Provisional; Region: PRK03636 930170004779 UPF0302 domain; Region: UPF0302; pfam08864 930170004780 IDEAL domain; Region: IDEAL; pfam08858 930170004781 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 930170004782 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 930170004783 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 930170004784 iron-sulfur cluster [ion binding]; other site 930170004785 [2Fe-2S] cluster binding site [ion binding]; other site 930170004786 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 930170004787 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 930170004788 interchain domain interface [polypeptide binding]; other site 930170004789 intrachain domain interface; other site 930170004790 heme bH binding site [chemical binding]; other site 930170004791 Qi binding site; other site 930170004792 heme bL binding site [chemical binding]; other site 930170004793 Qo binding site; other site 930170004794 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 930170004795 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 930170004796 interchain domain interface [polypeptide binding]; other site 930170004797 intrachain domain interface; other site 930170004798 Qi binding site; other site 930170004799 Qo binding site; other site 930170004800 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 930170004801 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 930170004802 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 930170004803 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 930170004804 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 930170004805 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 930170004806 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 930170004807 active site 930170004808 Fe-S cluster binding site [ion binding]; other site 930170004809 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170004810 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170004811 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170004812 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170004813 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 930170004814 homodimer interface [polypeptide binding]; other site 930170004815 metal binding site [ion binding]; metal-binding site 930170004816 dihydrodipicolinate reductase; Provisional; Region: PRK00048 930170004817 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 930170004818 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 930170004819 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 930170004820 active site 930170004821 dimer interfaces [polypeptide binding]; other site 930170004822 catalytic residues [active] 930170004823 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 930170004824 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 930170004825 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 930170004826 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 930170004827 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 930170004828 active site 930170004829 NTP binding site [chemical binding]; other site 930170004830 metal binding triad [ion binding]; metal-binding site 930170004831 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 930170004832 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 930170004833 Biotin operon repressor [Transcription]; Region: BirA; COG1654 930170004834 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 930170004835 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 930170004836 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 930170004837 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 930170004838 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 930170004839 oligomerization interface [polypeptide binding]; other site 930170004840 active site 930170004841 metal binding site [ion binding]; metal-binding site 930170004842 pantoate--beta-alanine ligase; Region: panC; TIGR00018 930170004843 Pantoate-beta-alanine ligase; Region: PanC; cd00560 930170004844 active site 930170004845 ATP-binding site [chemical binding]; other site 930170004846 pantoate-binding site; other site 930170004847 HXXH motif; other site 930170004848 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 930170004849 tetramerization interface [polypeptide binding]; other site 930170004850 active site 930170004851 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 930170004852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930170004853 active site 930170004854 catalytic site [active] 930170004855 substrate binding site [chemical binding]; other site 930170004856 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 930170004857 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930170004858 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 930170004859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 930170004860 aspartate aminotransferase; Provisional; Region: PRK05764 930170004861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170004862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170004863 homodimer interface [polypeptide binding]; other site 930170004864 catalytic residue [active] 930170004865 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 930170004866 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 930170004867 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930170004868 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 930170004869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930170004870 minor groove reading motif; other site 930170004871 helix-hairpin-helix signature motif; other site 930170004872 substrate binding pocket [chemical binding]; other site 930170004873 active site 930170004874 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 930170004875 Transglycosylase; Region: Transgly; pfam00912 930170004876 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930170004877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 930170004878 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930170004879 Interdomain contacts; other site 930170004880 Cytokine receptor motif; other site 930170004881 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 930170004882 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 930170004883 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 930170004884 YppF-like protein; Region: YppF; pfam14178 930170004885 YppG-like protein; Region: YppG; pfam14179 930170004886 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 930170004887 hypothetical protein; Provisional; Region: PRK13660 930170004888 cell division protein GpsB; Provisional; Region: PRK14127 930170004889 DivIVA domain; Region: DivI1A_domain; TIGR03544 930170004890 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 930170004891 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 930170004892 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 930170004893 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 930170004894 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 930170004895 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 930170004896 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930170004897 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 930170004898 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 930170004899 active site 930170004900 Zn binding site [ion binding]; other site 930170004901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170004902 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170004903 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 930170004904 Phosphotransferase enzyme family; Region: APH; pfam01636 930170004905 putative active site [active] 930170004906 putative substrate binding site [chemical binding]; other site 930170004907 ATP binding site [chemical binding]; other site 930170004908 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930170004909 active site 930170004910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170004911 active site 930170004912 xanthine permease; Region: pbuX; TIGR03173 930170004913 Predicted membrane protein [Function unknown]; Region: COG2311 930170004914 Protein of unknown function (DUF418); Region: DUF418; cl12135 930170004915 Protein of unknown function (DUF418); Region: DUF418; pfam04235 930170004916 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 930170004917 Dynamin family; Region: Dynamin_N; pfam00350 930170004918 G1 box; other site 930170004919 GTP/Mg2+ binding site [chemical binding]; other site 930170004920 G2 box; other site 930170004921 Switch I region; other site 930170004922 G3 box; other site 930170004923 Switch II region; other site 930170004924 G4 box; other site 930170004925 G5 box; other site 930170004926 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930170004927 Dynamin family; Region: Dynamin_N; pfam00350 930170004928 G1 box; other site 930170004929 GTP/Mg2+ binding site [chemical binding]; other site 930170004930 G2 box; other site 930170004931 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 930170004932 G3 box; other site 930170004933 Switch II region; other site 930170004934 GTP/Mg2+ binding site [chemical binding]; other site 930170004935 G4 box; other site 930170004936 G5 box; other site 930170004937 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 930170004938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170004939 Coenzyme A binding pocket [chemical binding]; other site 930170004940 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 930170004941 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 930170004942 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 930170004943 active site residue [active] 930170004944 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 930170004945 active site residue [active] 930170004946 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 930170004947 Predicted membrane protein [Function unknown]; Region: COG3766 930170004948 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 930170004949 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 930170004950 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 930170004951 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170004952 5'-3' exonuclease; Region: 53EXOc; smart00475 930170004953 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930170004954 active site 930170004955 metal binding site 1 [ion binding]; metal-binding site 930170004956 putative 5' ssDNA interaction site; other site 930170004957 metal binding site 3; metal-binding site 930170004958 metal binding site 2 [ion binding]; metal-binding site 930170004959 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930170004960 putative DNA binding site [nucleotide binding]; other site 930170004961 putative metal binding site [ion binding]; other site 930170004962 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 930170004963 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 930170004964 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 930170004965 Chain length determinant protein; Region: Wzz; cl15801 930170004966 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 930170004967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930170004968 Bacterial sugar transferase; Region: Bac_transf; pfam02397 930170004969 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930170004970 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 930170004971 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 930170004972 O-Antigen ligase; Region: Wzy_C; pfam04932 930170004973 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930170004974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930170004975 active site 930170004976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930170004977 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 930170004978 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 930170004979 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004980 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004981 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004982 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004983 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004984 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004985 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004986 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004987 Domain of unknown function DUF11; Region: DUF11; cl17728 930170004988 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004989 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004990 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004991 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004992 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004993 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004994 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004995 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004996 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004997 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004998 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170004999 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005000 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005001 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005002 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005003 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005004 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005005 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170005006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170005007 Coenzyme A binding pocket [chemical binding]; other site 930170005008 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 930170005009 Isochorismatase family; Region: Isochorismatase; pfam00857 930170005010 catalytic triad [active] 930170005011 conserved cis-peptide bond; other site 930170005012 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170005013 EamA-like transporter family; Region: EamA; pfam00892 930170005014 EamA-like transporter family; Region: EamA; pfam00892 930170005015 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 930170005016 RNA/DNA hybrid binding site [nucleotide binding]; other site 930170005017 active site 930170005018 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 930170005019 active site 930170005020 catalytic residues [active] 930170005021 QueT transporter; Region: QueT; pfam06177 930170005022 hypothetical protein; Validated; Region: PRK07708 930170005023 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 930170005024 RNA/DNA hybrid binding site [nucleotide binding]; other site 930170005025 active site 930170005026 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 930170005027 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 930170005028 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930170005029 DNA-binding site [nucleotide binding]; DNA binding site 930170005030 RNA-binding motif; other site 930170005031 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 930170005032 LysE type translocator; Region: LysE; pfam01810 930170005033 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 930170005034 Protein of unknown function, DUF485; Region: DUF485; pfam04341 930170005035 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 930170005036 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 930170005037 Na binding site [ion binding]; other site 930170005038 aminotransferase; Validated; Region: PRK07678 930170005039 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170005040 inhibitor-cofactor binding pocket; inhibition site 930170005041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170005042 catalytic residue [active] 930170005043 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930170005044 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930170005045 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930170005046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170005047 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930170005048 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170005049 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 930170005050 DNA binding residues [nucleotide binding] 930170005051 drug binding residues [chemical binding]; other site 930170005052 dimer interface [polypeptide binding]; other site 930170005053 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 930170005054 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 930170005055 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 930170005056 Predicted membrane protein [Function unknown]; Region: COG2323 930170005057 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930170005058 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930170005059 putative active site [active] 930170005060 Tic20-like protein; Region: Tic20; pfam09685 930170005061 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930170005062 dimer interface [polypeptide binding]; other site 930170005063 FMN binding site [chemical binding]; other site 930170005064 NADPH bind site [chemical binding]; other site 930170005065 DJ-1 family protein; Region: not_thiJ; TIGR01383 930170005066 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 930170005067 conserved cys residue [active] 930170005068 RNA polymerase factor sigma-70; Validated; Region: PRK06811 930170005069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170005070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170005071 DNA binding residues [nucleotide binding] 930170005072 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170005073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005074 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170005075 putative substrate translocation pore; other site 930170005076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170005077 dimerization interface [polypeptide binding]; other site 930170005078 putative DNA binding site [nucleotide binding]; other site 930170005079 putative Zn2+ binding site [ion binding]; other site 930170005080 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930170005081 active site 930170005082 metal binding site [ion binding]; metal-binding site 930170005083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170005084 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 930170005085 bacterial Hfq-like; Region: Hfq; cd01716 930170005086 hexamer interface [polypeptide binding]; other site 930170005087 Sm1 motif; other site 930170005088 RNA binding site [nucleotide binding]; other site 930170005089 Sm2 motif; other site 930170005090 HD domain; Region: HD_3; pfam13023 930170005091 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 930170005092 flagellar motor protein MotP; Reviewed; Region: PRK06743 930170005093 flagellar motor protein MotS; Reviewed; Region: PRK06742 930170005094 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 930170005095 ligand binding site [chemical binding]; other site 930170005096 Response regulator receiver domain; Region: Response_reg; pfam00072 930170005097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005098 active site 930170005099 phosphorylation site [posttranslational modification] 930170005100 intermolecular recognition site; other site 930170005101 dimerization interface [polypeptide binding]; other site 930170005102 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 930170005103 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 930170005104 putative binding surface; other site 930170005105 active site 930170005106 P2 response regulator binding domain; Region: P2; pfam07194 930170005107 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 930170005108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170005109 ATP binding site [chemical binding]; other site 930170005110 Mg2+ binding site [ion binding]; other site 930170005111 G-X-G motif; other site 930170005112 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 930170005113 flagellar motor switch protein; Reviewed; Region: PRK06782 930170005114 CheC-like family; Region: CheC; pfam04509 930170005115 CheC-like family; Region: CheC; pfam04509 930170005116 CheC-like family; Region: CheC; pfam04509 930170005117 CheC-like family; Region: CheC; pfam04509 930170005118 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 930170005119 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 930170005120 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 930170005121 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 930170005122 Protein of unknown function (DUF327); Region: DUF327; pfam03885 930170005123 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 930170005124 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930170005125 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 930170005126 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930170005127 flagellar capping protein; Validated; Region: fliD; PRK06798 930170005128 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 930170005129 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 930170005130 Flagellar protein FliS; Region: FliS; cl00654 930170005131 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 930170005132 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 930170005133 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 930170005134 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930170005135 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 930170005136 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 930170005137 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 930170005138 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 930170005139 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 930170005140 FliG C-terminal domain; Region: FliG_C; pfam01706 930170005141 flagellar assembly protein H; Validated; Region: fliH; PRK06800 930170005142 Flagellar assembly protein FliH; Region: FliH; pfam02108 930170005143 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 930170005144 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930170005145 Walker A motif; other site 930170005146 ATP binding site [chemical binding]; other site 930170005147 Walker B motif; other site 930170005148 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 930170005149 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 930170005150 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 930170005151 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 930170005152 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 930170005153 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 930170005154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930170005155 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 930170005156 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 930170005157 Response regulator receiver domain; Region: Response_reg; pfam00072 930170005158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005159 active site 930170005160 phosphorylation site [posttranslational modification] 930170005161 intermolecular recognition site; other site 930170005162 dimerization interface [polypeptide binding]; other site 930170005163 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 930170005164 flagellin; Provisional; Region: PRK12807 930170005165 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930170005166 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 930170005167 flagellin; Provisional; Region: PRK12808 930170005168 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930170005169 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 930170005170 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 930170005171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930170005172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930170005173 catalytic residue [active] 930170005174 flagellar motor switch protein; Validated; Region: PRK06789 930170005175 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 930170005176 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 930170005177 flagellar motor switch protein; Validated; Region: PRK06788 930170005178 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 930170005179 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 930170005180 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 930170005181 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 930170005182 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 930170005183 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 930170005184 FHIPEP family; Region: FHIPEP; pfam00771 930170005185 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 930170005186 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930170005187 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 930170005188 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 930170005189 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 930170005190 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 930170005191 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 930170005192 Predicted transcriptional regulators [Transcription]; Region: COG1378 930170005193 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 930170005194 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 930170005195 C-terminal domain interface [polypeptide binding]; other site 930170005196 sugar binding site [chemical binding]; other site 930170005197 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 930170005198 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 930170005199 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 930170005200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170005201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170005202 Dienelactone hydrolase family; Region: DLH; pfam01738 930170005203 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 930170005204 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 930170005205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170005206 non-specific DNA binding site [nucleotide binding]; other site 930170005207 salt bridge; other site 930170005208 sequence-specific DNA binding site [nucleotide binding]; other site 930170005209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005210 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170005211 putative substrate translocation pore; other site 930170005212 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 930170005213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170005214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170005215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170005216 dimerization interface [polypeptide binding]; other site 930170005217 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930170005218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170005219 Walker A/P-loop; other site 930170005220 ATP binding site [chemical binding]; other site 930170005221 Q-loop/lid; other site 930170005222 ABC transporter signature motif; other site 930170005223 Walker B; other site 930170005224 D-loop; other site 930170005225 H-loop/switch region; other site 930170005226 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 930170005227 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 930170005228 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 930170005229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170005230 dimer interface [polypeptide binding]; other site 930170005231 conserved gate region; other site 930170005232 putative PBP binding loops; other site 930170005233 ABC-ATPase subunit interface; other site 930170005234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170005235 dimer interface [polypeptide binding]; other site 930170005236 conserved gate region; other site 930170005237 putative PBP binding loops; other site 930170005238 ABC-ATPase subunit interface; other site 930170005239 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 930170005240 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 930170005241 Beta-Casp domain; Region: Beta-Casp; smart01027 930170005242 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930170005243 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 930170005244 short chain dehydrogenase; Provisional; Region: PRK08226 930170005245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170005246 NAD(P) binding site [chemical binding]; other site 930170005247 active site 930170005248 Cupin; Region: Cupin_1; smart00835 930170005249 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 930170005250 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 930170005251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170005252 catalytic core [active] 930170005253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170005254 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 930170005255 hypothetical protein; Provisional; Region: PRK09272 930170005256 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170005257 MarR family; Region: MarR_2; pfam12802 930170005258 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 930170005259 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 930170005260 active site 930170005261 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 930170005262 dimer interface [polypeptide binding]; other site 930170005263 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 930170005264 Ligand Binding Site [chemical binding]; other site 930170005265 Molecular Tunnel; other site 930170005266 RNA polymerase factor sigma-70; Validated; Region: PRK06811 930170005267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170005268 DNA binding residues [nucleotide binding] 930170005269 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 930170005270 VPS10 domain; Region: VPS10; smart00602 930170005271 VPS10 domain; Region: VPS10; smart00602 930170005272 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 930170005273 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 930170005274 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930170005275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170005276 DNA-binding site [nucleotide binding]; DNA binding site 930170005277 FCD domain; Region: FCD; pfam07729 930170005278 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170005279 EamA-like transporter family; Region: EamA; pfam00892 930170005280 EamA-like transporter family; Region: EamA; pfam00892 930170005281 Methyltransferase domain; Region: Methyltransf_24; pfam13578 930170005282 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 930170005283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170005284 fumarate hydratase; Reviewed; Region: fumC; PRK00485 930170005285 Class II fumarases; Region: Fumarase_classII; cd01362 930170005286 active site 930170005287 tetramer interface [polypeptide binding]; other site 930170005288 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 930170005289 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 930170005290 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930170005291 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 930170005292 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 930170005293 active site pocket [active] 930170005294 oxyanion hole [active] 930170005295 catalytic triad [active] 930170005296 active site nucleophile [active] 930170005297 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 930170005298 Penicillinase repressor; Region: Pencillinase_R; pfam03965 930170005299 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 930170005300 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 930170005301 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930170005302 catalytic residues [active] 930170005303 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 930170005304 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930170005305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170005306 non-specific DNA binding site [nucleotide binding]; other site 930170005307 salt bridge; other site 930170005308 sequence-specific DNA binding site [nucleotide binding]; other site 930170005309 Cupin domain; Region: Cupin_2; pfam07883 930170005310 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 930170005311 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 930170005312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170005313 catalytic residue [active] 930170005314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170005315 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 930170005316 AAA domain; Region: AAA_12; pfam13087 930170005317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170005318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170005319 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170005320 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170005321 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 930170005322 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 930170005323 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 930170005324 DltD N-terminal region; Region: DltD_N; pfam04915 930170005325 DltD central region; Region: DltD_M; pfam04918 930170005326 DltD C-terminal region; Region: DltD_C; pfam04914 930170005327 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 930170005328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170005329 Protein of unknown function (DUF445); Region: DUF445; pfam04286 930170005330 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 930170005331 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 930170005332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170005333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170005334 DNA binding residues [nucleotide binding] 930170005335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170005336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005337 active site 930170005338 phosphorylation site [posttranslational modification] 930170005339 intermolecular recognition site; other site 930170005340 dimerization interface [polypeptide binding]; other site 930170005341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170005342 DNA binding residues [nucleotide binding] 930170005343 dimerization interface [polypeptide binding]; other site 930170005344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170005345 Histidine kinase; Region: HisKA_3; pfam07730 930170005346 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 930170005347 Mg2+ binding site [ion binding]; other site 930170005348 G-X-G motif; other site 930170005349 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170005350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170005351 Walker A/P-loop; other site 930170005352 ATP binding site [chemical binding]; other site 930170005353 Q-loop/lid; other site 930170005354 ABC transporter signature motif; other site 930170005355 Walker B; other site 930170005356 D-loop; other site 930170005357 H-loop/switch region; other site 930170005358 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930170005359 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930170005360 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930170005361 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930170005362 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930170005363 PLD-like domain; Region: PLDc_2; pfam13091 930170005364 putative active site [active] 930170005365 catalytic site [active] 930170005366 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930170005367 PLD-like domain; Region: PLDc_2; pfam13091 930170005368 putative active site [active] 930170005369 catalytic site [active] 930170005370 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 930170005371 putative nucleotide binding site [chemical binding]; other site 930170005372 uridine monophosphate binding site [chemical binding]; other site 930170005373 homohexameric interface [polypeptide binding]; other site 930170005374 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930170005375 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 930170005376 aspartate ammonia-lyase; Provisional; Region: PRK14515 930170005377 Aspartase; Region: Aspartase; cd01357 930170005378 active sites [active] 930170005379 tetramer interface [polypeptide binding]; other site 930170005380 malate dehydrogenase; Provisional; Region: PRK13529 930170005381 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930170005382 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 930170005383 NAD(P) binding site [chemical binding]; other site 930170005384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170005385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170005386 ATP binding site [chemical binding]; other site 930170005387 Mg2+ binding site [ion binding]; other site 930170005388 G-X-G motif; other site 930170005389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005390 Response regulator receiver domain; Region: Response_reg; pfam00072 930170005391 active site 930170005392 phosphorylation site [posttranslational modification] 930170005393 intermolecular recognition site; other site 930170005394 dimerization interface [polypeptide binding]; other site 930170005395 YcbB domain; Region: YcbB; pfam08664 930170005396 SWIM zinc finger; Region: SWIM; pfam04434 930170005397 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 930170005398 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 930170005399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170005400 ATP binding site [chemical binding]; other site 930170005401 putative Mg++ binding site [ion binding]; other site 930170005402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170005403 nucleotide binding region [chemical binding]; other site 930170005404 ATP-binding site [chemical binding]; other site 930170005405 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 930170005406 dimer interface [polypeptide binding]; other site 930170005407 active site 930170005408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170005409 non-specific DNA binding site [nucleotide binding]; other site 930170005410 salt bridge; other site 930170005411 sequence-specific DNA binding site [nucleotide binding]; other site 930170005412 Helix-turn-helix; Region: HTH_3; pfam01381 930170005413 salt bridge; other site 930170005414 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 930170005415 putative dimer interface [polypeptide binding]; other site 930170005416 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170005417 aspartate kinase; Reviewed; Region: PRK06635 930170005418 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 930170005419 putative nucleotide binding site [chemical binding]; other site 930170005420 putative catalytic residues [active] 930170005421 putative Mg ion binding site [ion binding]; other site 930170005422 putative aspartate binding site [chemical binding]; other site 930170005423 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 930170005424 putative allosteric regulatory site; other site 930170005425 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 930170005426 putative allosteric regulatory residue; other site 930170005427 DoxX-like family; Region: DoxX_3; pfam13781 930170005428 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 930170005429 YndJ-like protein; Region: YndJ; pfam14158 930170005430 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 930170005431 putative active site [active] 930170005432 nucleotide binding site [chemical binding]; other site 930170005433 nudix motif; other site 930170005434 putative metal binding site [ion binding]; other site 930170005435 S-layer homology domain; Region: SLH; pfam00395 930170005436 S-layer homology domain; Region: SLH; pfam00395 930170005437 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930170005438 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930170005439 active site 930170005440 metal binding site [ion binding]; metal-binding site 930170005441 S-layer homology domain; Region: SLH; pfam00395 930170005442 S-layer homology domain; Region: SLH; pfam00395 930170005443 S-layer homology domain; Region: SLH; pfam00395 930170005444 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 930170005445 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170005446 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170005447 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170005448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005449 putative substrate translocation pore; other site 930170005450 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 930170005451 Carbon starvation protein CstA; Region: CstA; pfam02554 930170005452 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 930170005453 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 930170005454 Transposase IS200 like; Region: Y1_Tnp; pfam01797 930170005455 Probable transposase; Region: OrfB_IS605; pfam01385 930170005456 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170005457 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170005458 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170005459 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170005460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170005462 putative substrate translocation pore; other site 930170005463 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930170005464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170005466 putative substrate translocation pore; other site 930170005467 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 930170005468 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930170005469 dimer interface [polypeptide binding]; other site 930170005470 active site 930170005471 CoA binding pocket [chemical binding]; other site 930170005472 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 930170005473 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 930170005474 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930170005475 HflX GTPase family; Region: HflX; cd01878 930170005476 G1 box; other site 930170005477 GTP/Mg2+ binding site [chemical binding]; other site 930170005478 Switch I region; other site 930170005479 G2 box; other site 930170005480 G3 box; other site 930170005481 Switch II region; other site 930170005482 G4 box; other site 930170005483 G5 box; other site 930170005484 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170005485 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170005486 peptide binding site [polypeptide binding]; other site 930170005487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170005489 putative substrate translocation pore; other site 930170005490 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930170005491 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930170005492 dimer interface [polypeptide binding]; other site 930170005493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170005494 catalytic residue [active] 930170005495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170005496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170005497 Coenzyme A binding pocket [chemical binding]; other site 930170005498 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 930170005499 stage V sporulation protein B; Region: spore_V_B; TIGR02900 930170005500 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930170005501 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 930170005502 Na2 binding site [ion binding]; other site 930170005503 putative substrate binding site 1 [chemical binding]; other site 930170005504 Na binding site 1 [ion binding]; other site 930170005505 putative substrate binding site 2 [chemical binding]; other site 930170005506 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170005507 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 930170005508 NodB motif; other site 930170005509 putative active site [active] 930170005510 putative catalytic site [active] 930170005511 putative Zn binding site [ion binding]; other site 930170005512 Mor transcription activator family; Region: Mor; cl02360 930170005513 Predicted membrane protein [Function unknown]; Region: COG2323 930170005514 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 930170005515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 930170005516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 930170005517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 930170005518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 930170005519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 930170005520 methionine sulfoxide reductase A; Provisional; Region: PRK14054 930170005521 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930170005522 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 930170005523 homodimer interface [polypeptide binding]; other site 930170005524 substrate-cofactor binding pocket; other site 930170005525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170005526 catalytic residue [active] 930170005527 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 930170005528 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930170005529 PYR/PP interface [polypeptide binding]; other site 930170005530 dimer interface [polypeptide binding]; other site 930170005531 TPP binding site [chemical binding]; other site 930170005532 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170005533 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 930170005534 TPP-binding site [chemical binding]; other site 930170005535 dimer interface [polypeptide binding]; other site 930170005536 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 930170005537 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 930170005538 putative valine binding site [chemical binding]; other site 930170005539 dimer interface [polypeptide binding]; other site 930170005540 ketol-acid reductoisomerase; Provisional; Region: PRK05479 930170005541 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 930170005542 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 930170005543 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 930170005544 threonine dehydratase; Validated; Region: PRK08639 930170005545 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 930170005546 tetramer interface [polypeptide binding]; other site 930170005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170005548 catalytic residue [active] 930170005549 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 930170005550 putative Ile/Val binding site [chemical binding]; other site 930170005551 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 930170005552 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 930170005553 putative active site [active] 930170005554 putative metal binding site [ion binding]; other site 930170005555 Protein of unknown function (DUF554); Region: DUF554; pfam04474 930170005556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170005557 Coenzyme A binding pocket [chemical binding]; other site 930170005558 drug efflux system protein MdtG; Provisional; Region: PRK09874 930170005559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005560 putative substrate translocation pore; other site 930170005561 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 930170005562 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 930170005563 putative active site [active] 930170005564 metal binding site [ion binding]; metal-binding site 930170005565 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 930170005566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930170005567 LytTr DNA-binding domain; Region: LytTR; pfam04397 930170005568 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930170005569 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 930170005570 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 930170005571 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 930170005572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170005573 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 930170005574 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 930170005575 active site 930170005576 putative substrate binding pocket [chemical binding]; other site 930170005577 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170005578 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170005579 peptide binding site [polypeptide binding]; other site 930170005580 hypothetical protein; Provisional; Region: PRK06922 930170005581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170005582 S-adenosylmethionine binding site [chemical binding]; other site 930170005583 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 930170005584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170005585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170005586 Coenzyme A binding pocket [chemical binding]; other site 930170005587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170005588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005589 active site 930170005590 phosphorylation site [posttranslational modification] 930170005591 intermolecular recognition site; other site 930170005592 dimerization interface [polypeptide binding]; other site 930170005593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170005594 DNA binding site [nucleotide binding] 930170005595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170005596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170005597 dimerization interface [polypeptide binding]; other site 930170005598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170005599 dimer interface [polypeptide binding]; other site 930170005600 phosphorylation site [posttranslational modification] 930170005601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170005602 ATP binding site [chemical binding]; other site 930170005603 Mg2+ binding site [ion binding]; other site 930170005604 G-X-G motif; other site 930170005605 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170005606 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170005607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170005608 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930170005609 TAP-like protein; Region: Abhydrolase_4; pfam08386 930170005610 manganese transport protein MntH; Reviewed; Region: PRK00701 930170005611 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930170005612 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 930170005613 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 930170005614 active site residue [active] 930170005615 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 930170005616 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 930170005617 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 930170005618 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 930170005619 Amino acid permease; Region: AA_permease_2; pfam13520 930170005620 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170005621 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170005622 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170005623 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 930170005624 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930170005625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170005626 DNA binding residues [nucleotide binding] 930170005627 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930170005628 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 930170005629 intersubunit interface [polypeptide binding]; other site 930170005630 active site 930170005631 catalytic residue [active] 930170005632 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170005633 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170005634 Nucleoside recognition; Region: Gate; pfam07670 930170005635 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170005636 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 930170005637 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930170005638 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930170005639 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 930170005640 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 930170005641 active site 930170005642 catalytic motif [active] 930170005643 Zn binding site [ion binding]; other site 930170005644 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 930170005645 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 930170005646 hypothetical protein; Provisional; Region: PRK01631 930170005647 proline aminopeptidase P II; Provisional; Region: PRK10879 930170005648 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 930170005649 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 930170005650 active site 930170005651 DNA topoisomerase III; Provisional; Region: PRK07726 930170005652 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 930170005653 active site 930170005654 putative interdomain interaction site [polypeptide binding]; other site 930170005655 putative metal-binding site [ion binding]; other site 930170005656 putative nucleotide binding site [chemical binding]; other site 930170005657 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930170005658 domain I; other site 930170005659 DNA binding groove [nucleotide binding] 930170005660 phosphate binding site [ion binding]; other site 930170005661 domain II; other site 930170005662 domain III; other site 930170005663 nucleotide binding site [chemical binding]; other site 930170005664 catalytic site [active] 930170005665 domain IV; other site 930170005666 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930170005667 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 930170005668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005669 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170005670 putative substrate translocation pore; other site 930170005671 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 930170005672 Sodium Bile acid symporter family; Region: SBF; cl17470 930170005673 azoreductase; Provisional; Region: PRK13555 930170005674 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 930170005675 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170005676 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 930170005677 dimer interface [polypeptide binding]; other site 930170005678 substrate binding site [chemical binding]; other site 930170005679 metal binding site [ion binding]; metal-binding site 930170005680 CopC domain; Region: CopC; pfam04234 930170005681 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 930170005682 YtkA-like; Region: YtkA; pfam13115 930170005683 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 930170005684 EamA-like transporter family; Region: EamA; pfam00892 930170005685 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170005686 EamA-like transporter family; Region: EamA; pfam00892 930170005687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170005688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170005689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170005690 dimerization interface [polypeptide binding]; other site 930170005691 Predicted transcriptional regulator [Transcription]; Region: COG1959 930170005692 Transcriptional regulator; Region: Rrf2; pfam02082 930170005693 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 930170005694 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 930170005695 catalytic residues [active] 930170005696 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 930170005697 dimer interface [polypeptide binding]; other site 930170005698 FMN binding site [chemical binding]; other site 930170005699 amidase; Provisional; Region: PRK06707 930170005700 Amidase; Region: Amidase; cl11426 930170005701 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930170005702 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 930170005703 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930170005704 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170005705 NAD binding site [chemical binding]; other site 930170005706 dimer interface [polypeptide binding]; other site 930170005707 substrate binding site [chemical binding]; other site 930170005708 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 930170005709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170005710 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 930170005711 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 930170005712 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 930170005713 S-layer homology domain; Region: SLH; pfam00395 930170005714 S-layer homology domain; Region: SLH; pfam00395 930170005715 S-layer homology domain; Region: SLH; pfam00395 930170005716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170005717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170005718 acyl-CoA synthetase; Validated; Region: PRK06839 930170005719 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170005720 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 930170005721 acyl-activating enzyme (AAE) consensus motif; other site 930170005722 putative AMP binding site [chemical binding]; other site 930170005723 putative active site [active] 930170005724 putative CoA binding site [chemical binding]; other site 930170005725 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 930170005726 dimer interaction site [polypeptide binding]; other site 930170005727 substrate-binding tunnel; other site 930170005728 active site 930170005729 catalytic site [active] 930170005730 substrate binding site [chemical binding]; other site 930170005731 hypothetical protein; Validated; Region: PRK06840 930170005732 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 930170005733 active site 930170005734 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 930170005735 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 930170005736 putative ligand binding site [chemical binding]; other site 930170005737 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 930170005738 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 930170005739 Walker A/P-loop; other site 930170005740 ATP binding site [chemical binding]; other site 930170005741 Q-loop/lid; other site 930170005742 ABC transporter signature motif; other site 930170005743 Walker B; other site 930170005744 D-loop; other site 930170005745 H-loop/switch region; other site 930170005746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 930170005747 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 930170005748 Walker A/P-loop; other site 930170005749 ATP binding site [chemical binding]; other site 930170005750 Q-loop/lid; other site 930170005751 ABC transporter signature motif; other site 930170005752 Walker B; other site 930170005753 D-loop; other site 930170005754 H-loop/switch region; other site 930170005755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170005756 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 930170005757 TM-ABC transporter signature motif; other site 930170005758 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 930170005759 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 930170005760 TM-ABC transporter signature motif; other site 930170005761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170005762 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 930170005763 LysR substrate binding domain; Region: LysR_substrate; pfam03466 930170005764 dimerization interface [polypeptide binding]; other site 930170005765 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 930170005766 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 930170005767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170005768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170005769 putative Zn2+ binding site [ion binding]; other site 930170005770 putative DNA binding site [nucleotide binding]; other site 930170005771 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 930170005772 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 930170005773 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 930170005774 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 930170005775 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 930170005776 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 930170005777 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 930170005778 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 930170005779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170005780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170005781 Walker A/P-loop; other site 930170005782 ATP binding site [chemical binding]; other site 930170005783 Q-loop/lid; other site 930170005784 ABC transporter signature motif; other site 930170005785 Walker B; other site 930170005786 D-loop; other site 930170005787 H-loop/switch region; other site 930170005788 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 930170005789 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170005790 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 930170005791 Walker A/P-loop; other site 930170005792 ATP binding site [chemical binding]; other site 930170005793 Q-loop/lid; other site 930170005794 ABC transporter signature motif; other site 930170005795 Walker B; other site 930170005796 D-loop; other site 930170005797 H-loop/switch region; other site 930170005798 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930170005799 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 930170005800 active site 930170005801 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170005802 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170005803 active site 930170005804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170005805 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170005806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 930170005807 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 930170005808 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 930170005809 inhibitor-cofactor binding pocket; inhibition site 930170005810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170005811 catalytic residue [active] 930170005812 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 930170005813 trimer interface [polypeptide binding]; other site 930170005814 active site 930170005815 substrate binding site [chemical binding]; other site 930170005816 CoA binding site [chemical binding]; other site 930170005817 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930170005818 putative dimer interface [polypeptide binding]; other site 930170005819 catalytic triad [active] 930170005820 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170005821 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 930170005822 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 930170005823 dimer interface [polypeptide binding]; other site 930170005824 FMN binding site [chemical binding]; other site 930170005825 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170005826 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170005827 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170005828 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930170005829 NlpC/P60 family; Region: NLPC_P60; pfam00877 930170005830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170005831 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170005832 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170005833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170005834 Walker A/P-loop; other site 930170005835 ATP binding site [chemical binding]; other site 930170005836 Q-loop/lid; other site 930170005837 ABC transporter signature motif; other site 930170005838 Walker B; other site 930170005839 D-loop; other site 930170005840 H-loop/switch region; other site 930170005841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170005842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005843 active site 930170005844 phosphorylation site [posttranslational modification] 930170005845 intermolecular recognition site; other site 930170005846 dimerization interface [polypeptide binding]; other site 930170005847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170005848 DNA binding site [nucleotide binding] 930170005849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170005850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170005851 dimerization interface [polypeptide binding]; other site 930170005852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170005853 dimer interface [polypeptide binding]; other site 930170005854 phosphorylation site [posttranslational modification] 930170005855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170005856 ATP binding site [chemical binding]; other site 930170005857 Mg2+ binding site [ion binding]; other site 930170005858 G-X-G motif; other site 930170005859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170005860 dimer interface [polypeptide binding]; other site 930170005861 phosphorylation site [posttranslational modification] 930170005862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170005863 ATP binding site [chemical binding]; other site 930170005864 Mg2+ binding site [ion binding]; other site 930170005865 G-X-G motif; other site 930170005866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170005867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170005868 active site 930170005869 phosphorylation site [posttranslational modification] 930170005870 intermolecular recognition site; other site 930170005871 dimerization interface [polypeptide binding]; other site 930170005872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170005873 DNA binding site [nucleotide binding] 930170005874 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 930170005875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 930170005876 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170005877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 930170005878 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170005879 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170005880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170005881 Walker A/P-loop; other site 930170005882 ATP binding site [chemical binding]; other site 930170005883 Q-loop/lid; other site 930170005884 ABC transporter signature motif; other site 930170005885 Walker B; other site 930170005886 D-loop; other site 930170005887 H-loop/switch region; other site 930170005888 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 930170005889 classical (c) SDRs; Region: SDR_c; cd05233 930170005890 NAD(P) binding site [chemical binding]; other site 930170005891 active site 930170005892 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 930170005893 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170005894 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 930170005895 NodB motif; other site 930170005896 active site 930170005897 catalytic site [active] 930170005898 metal binding site [ion binding]; metal-binding site 930170005899 SdpI/YhfL protein family; Region: SdpI; pfam13630 930170005900 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930170005901 nudix motif; other site 930170005902 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 930170005903 homoserine dehydrogenase; Provisional; Region: PRK06349 930170005904 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 930170005905 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 930170005906 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 930170005907 threonine synthase; Reviewed; Region: PRK06721 930170005908 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 930170005909 homodimer interface [polypeptide binding]; other site 930170005910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170005911 catalytic residue [active] 930170005912 homoserine kinase; Provisional; Region: PRK01212 930170005913 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930170005914 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930170005915 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 930170005916 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 930170005917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170005918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170005919 ATP binding site [chemical binding]; other site 930170005920 Mg2+ binding site [ion binding]; other site 930170005921 G-X-G motif; other site 930170005922 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170005923 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 930170005924 NodB motif; other site 930170005925 active site 930170005926 catalytic site [active] 930170005927 Zn binding site [ion binding]; other site 930170005928 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 930170005929 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 930170005930 MgtC family; Region: MgtC; pfam02308 930170005931 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 930170005932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170005933 Coenzyme A binding pocket [chemical binding]; other site 930170005934 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170005935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170005936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170005937 putative substrate translocation pore; other site 930170005938 Lysine efflux permease [General function prediction only]; Region: COG1279 930170005939 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 930170005940 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 930170005941 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 930170005942 active site 930170005943 nucleophile elbow; other site 930170005944 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 930170005945 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930170005946 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 930170005947 nudix motif; other site 930170005948 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 930170005949 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 930170005950 homodimer interface [polypeptide binding]; other site 930170005951 NAD binding pocket [chemical binding]; other site 930170005952 ATP binding pocket [chemical binding]; other site 930170005953 Mg binding site [ion binding]; other site 930170005954 active-site loop [active] 930170005955 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170005956 FtsX-like permease family; Region: FtsX; pfam02687 930170005957 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 930170005958 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 930170005959 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930170005960 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 930170005961 active site 930170005962 catalytic residues [active] 930170005963 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 930170005964 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 930170005965 Walker A/P-loop; other site 930170005966 ATP binding site [chemical binding]; other site 930170005967 Q-loop/lid; other site 930170005968 ABC transporter signature motif; other site 930170005969 Walker B; other site 930170005970 D-loop; other site 930170005971 H-loop/switch region; other site 930170005972 TOBE domain; Region: TOBE; pfam03459 930170005973 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930170005974 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 930170005975 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170005976 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 930170005977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930170005978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930170005979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170005980 ABC-ATPase subunit interface; other site 930170005981 putative PBP binding loops; other site 930170005982 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930170005983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170005984 dimer interface [polypeptide binding]; other site 930170005985 conserved gate region; other site 930170005986 putative PBP binding loops; other site 930170005987 ABC-ATPase subunit interface; other site 930170005988 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 930170005989 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 930170005990 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930170005991 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930170005992 nucleotide binding site [chemical binding]; other site 930170005993 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 930170005994 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930170005995 dimer interface [polypeptide binding]; other site 930170005996 active site 930170005997 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 930170005998 putative active site [active] 930170005999 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930170006000 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 930170006001 active site 930170006002 dimer interface [polypeptide binding]; other site 930170006003 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930170006004 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 930170006005 putative substrate binding site [chemical binding]; other site 930170006006 putative ATP binding site [chemical binding]; other site 930170006007 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 930170006008 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 930170006009 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 930170006010 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 930170006011 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 930170006012 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 930170006013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170006014 dimerization interface [polypeptide binding]; other site 930170006015 putative DNA binding site [nucleotide binding]; other site 930170006016 putative Zn2+ binding site [ion binding]; other site 930170006017 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930170006018 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930170006019 active site 930170006020 catalytic tetrad [active] 930170006021 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930170006022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006023 putative substrate translocation pore; other site 930170006024 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 930170006025 Protein of unknown function (DUF664); Region: DUF664; pfam04978 930170006026 GTPase RsgA; Reviewed; Region: PRK01889 930170006027 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930170006028 RNA binding site [nucleotide binding]; other site 930170006029 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930170006030 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930170006031 GTP/Mg2+ binding site [chemical binding]; other site 930170006032 G4 box; other site 930170006033 G5 box; other site 930170006034 G1 box; other site 930170006035 Switch I region; other site 930170006036 G2 box; other site 930170006037 G3 box; other site 930170006038 Switch II region; other site 930170006039 Tar ligand binding domain homologue; Region: TarH; pfam02203 930170006040 Cache domain; Region: Cache_1; pfam02743 930170006041 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930170006042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170006043 dimerization interface [polypeptide binding]; other site 930170006044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170006045 dimer interface [polypeptide binding]; other site 930170006046 putative CheW interface [polypeptide binding]; other site 930170006047 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 930170006048 Uncharacterized membrane protein [Function unknown]; Region: COG3949 930170006049 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 930170006050 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 930170006051 dimerization interface [polypeptide binding]; other site 930170006052 DPS ferroxidase diiron center [ion binding]; other site 930170006053 ion pore; other site 930170006054 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 930170006055 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930170006056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 930170006057 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 930170006058 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 930170006059 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 930170006060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170006061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170006062 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170006063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930170006064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930170006065 active site 930170006066 catalytic tetrad [active] 930170006067 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 930170006068 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 930170006069 P-loop, Walker A motif; other site 930170006070 Base recognition motif; other site 930170006071 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 930170006072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170006073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006074 Coenzyme A binding pocket [chemical binding]; other site 930170006075 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 930170006076 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 930170006077 metal binding site [ion binding]; metal-binding site 930170006078 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 930170006079 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930170006080 NAD binding site [chemical binding]; other site 930170006081 active site 930170006082 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930170006083 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 930170006084 active site 930170006085 FMN binding site [chemical binding]; other site 930170006086 substrate binding site [chemical binding]; other site 930170006087 homotetramer interface [polypeptide binding]; other site 930170006088 catalytic residue [active] 930170006089 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 930170006090 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 930170006091 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930170006092 DNA binding site [nucleotide binding] 930170006093 active site 930170006094 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 930170006095 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170006096 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170006097 peptide binding site [polypeptide binding]; other site 930170006098 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 930170006099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930170006100 active site 930170006101 metal binding site [ion binding]; metal-binding site 930170006102 short chain dehydrogenase; Provisional; Region: PRK08309 930170006103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170006104 catalytic core [active] 930170006105 CotH protein; Region: CotH; pfam08757 930170006106 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 930170006107 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 930170006108 nudix motif; other site 930170006109 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930170006110 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170006111 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930170006112 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930170006113 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 930170006114 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930170006115 Cl binding site [ion binding]; other site 930170006116 oligomer interface [polypeptide binding]; other site 930170006117 Predicted permeases [General function prediction only]; Region: COG0701 930170006118 Predicted membrane protein [Function unknown]; Region: COG3689 930170006119 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 930170006120 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 930170006121 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930170006122 putative active site [active] 930170006123 catalytic site [active] 930170006124 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930170006125 putative active site [active] 930170006126 catalytic site [active] 930170006127 Coat F domain; Region: Coat_F; pfam07875 930170006128 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 930170006129 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930170006130 NAD binding site [chemical binding]; other site 930170006131 substrate binding site [chemical binding]; other site 930170006132 putative active site [active] 930170006133 Protein of unknown function (DUF456); Region: DUF456; pfam04306 930170006134 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930170006135 Domain of unknown function DUF21; Region: DUF21; pfam01595 930170006136 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930170006137 Transporter associated domain; Region: CorC_HlyC; smart01091 930170006138 FOG: CBS domain [General function prediction only]; Region: COG0517 930170006139 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 930170006140 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 930170006141 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 930170006142 dimer interface [polypeptide binding]; other site 930170006143 putative tRNA-binding site [nucleotide binding]; other site 930170006144 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 930170006145 DinB superfamily; Region: DinB_2; pfam12867 930170006146 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 930170006147 stage II sporulation protein P; Region: spore_II_P; TIGR02867 930170006148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170006149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006150 Coenzyme A binding pocket [chemical binding]; other site 930170006151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170006152 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 930170006153 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930170006154 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930170006155 nudix motif; other site 930170006156 potential frameshift: common BLAST hit: gi|375284081|ref|YP_005104519.1| amidase family protein 930170006157 amidase; Provisional; Region: PRK06828 930170006158 Amidase; Region: Amidase; cl11426 930170006159 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170006160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006161 putative substrate translocation pore; other site 930170006162 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 930170006163 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 930170006164 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 930170006165 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170006166 catalytic core [active] 930170006167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170006168 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170006169 active site 930170006170 motif I; other site 930170006171 motif II; other site 930170006172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170006173 DinB superfamily; Region: DinB_2; pfam12867 930170006174 DinB family; Region: DinB; cl17821 930170006175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 930170006176 alanine racemase; Reviewed; Region: alr; PRK00053 930170006177 active site 930170006178 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930170006179 dimer interface [polypeptide binding]; other site 930170006180 substrate binding site [chemical binding]; other site 930170006181 catalytic residues [active] 930170006182 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170006183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170006184 S-adenosylmethionine binding site [chemical binding]; other site 930170006185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006186 Coenzyme A binding pocket [chemical binding]; other site 930170006187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006188 Coenzyme A binding pocket [chemical binding]; other site 930170006189 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 930170006190 glycosyltransferase, MGT family; Region: MGT; TIGR01426 930170006191 active site 930170006192 TDP-binding site; other site 930170006193 acceptor substrate-binding pocket; other site 930170006194 homodimer interface [polypeptide binding]; other site 930170006195 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170006196 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170006197 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170006198 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170006199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170006200 DNA-binding site [nucleotide binding]; DNA binding site 930170006201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170006202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170006203 homodimer interface [polypeptide binding]; other site 930170006204 catalytic residue [active] 930170006205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006206 Coenzyme A binding pocket [chemical binding]; other site 930170006207 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170006208 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 930170006209 active site 930170006210 metal binding site [ion binding]; metal-binding site 930170006211 Src Homology 3 domain superfamily; Region: SH3; cl17036 930170006212 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930170006213 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170006214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006215 Coenzyme A binding pocket [chemical binding]; other site 930170006216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170006217 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 930170006218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170006219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006220 Coenzyme A binding pocket [chemical binding]; other site 930170006221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006222 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170006223 Coenzyme A binding pocket [chemical binding]; other site 930170006224 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170006225 active site 930170006226 ATP binding site [chemical binding]; other site 930170006227 Phosphotransferase enzyme family; Region: APH; pfam01636 930170006228 substrate binding site [chemical binding]; other site 930170006229 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 930170006230 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170006231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170006232 S-adenosylmethionine binding site [chemical binding]; other site 930170006233 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 930170006234 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 930170006235 Potassium binding sites [ion binding]; other site 930170006236 Cesium cation binding sites [ion binding]; other site 930170006237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930170006238 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930170006239 ATP binding site [chemical binding]; other site 930170006240 putative Mg++ binding site [ion binding]; other site 930170006241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170006242 nucleotide binding region [chemical binding]; other site 930170006243 ATP-binding site [chemical binding]; other site 930170006244 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930170006245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170006246 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930170006247 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930170006248 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 930170006249 NADP binding site [chemical binding]; other site 930170006250 dimer interface [polypeptide binding]; other site 930170006251 potential frameshift: common BLAST hit: gi|163939932|ref|YP_001644816.1| RNA polymerase sigma factor 930170006252 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 930170006253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170006254 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 930170006255 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 930170006256 catalytic residues [active] 930170006257 dimer interface [polypeptide binding]; other site 930170006258 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930170006259 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930170006260 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 930170006261 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930170006262 Protein of unknown function DUF58; Region: DUF58; pfam01882 930170006263 MoxR-like ATPases [General function prediction only]; Region: COG0714 930170006264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170006265 Walker A motif; other site 930170006266 ATP binding site [chemical binding]; other site 930170006267 Walker B motif; other site 930170006268 arginine finger; other site 930170006269 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 930170006270 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 930170006271 [4Fe-4S] binding site [ion binding]; other site 930170006272 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 930170006273 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 930170006274 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 930170006275 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 930170006276 molybdopterin cofactor binding site; other site 930170006277 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 930170006278 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 930170006279 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 930170006280 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930170006281 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930170006282 ligand binding site [chemical binding]; other site 930170006283 flexible hinge region; other site 930170006284 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930170006285 putative switch regulator; other site 930170006286 non-specific DNA interactions [nucleotide binding]; other site 930170006287 DNA binding site [nucleotide binding] 930170006288 sequence specific DNA binding site [nucleotide binding]; other site 930170006289 putative cAMP binding site [chemical binding]; other site 930170006290 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 930170006291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170006292 FeS/SAM binding site; other site 930170006293 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 930170006294 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 930170006295 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930170006296 ATP binding site [chemical binding]; other site 930170006297 substrate interface [chemical binding]; other site 930170006298 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930170006299 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930170006300 dimer interface [polypeptide binding]; other site 930170006301 putative functional site; other site 930170006302 putative MPT binding site; other site 930170006303 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 930170006304 MoaE homodimer interface [polypeptide binding]; other site 930170006305 MoaD interaction [polypeptide binding]; other site 930170006306 active site residues [active] 930170006307 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 930170006308 MoaE interaction surface [polypeptide binding]; other site 930170006309 MoeB interaction surface [polypeptide binding]; other site 930170006310 thiocarboxylated glycine; other site 930170006311 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 930170006312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006313 putative substrate translocation pore; other site 930170006314 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 930170006315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930170006316 active site 930170006317 Membrane transport protein; Region: Mem_trans; cl09117 930170006318 precorrin-2 dehydrogenase; Validated; Region: PRK06719 930170006319 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 930170006320 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 930170006321 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 930170006322 putative active site [active] 930170006323 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 930170006324 putative active site [active] 930170006325 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 930170006326 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 930170006327 active site 930170006328 SAM binding site [chemical binding]; other site 930170006329 homodimer interface [polypeptide binding]; other site 930170006330 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930170006331 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 930170006332 [2Fe-2S] cluster binding site [ion binding]; other site 930170006333 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 930170006334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170006335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170006336 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930170006337 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930170006338 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930170006339 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 930170006340 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 930170006341 Hemerythrin-like domain; Region: Hr-like; cd12108 930170006342 Fe binding site [ion binding]; other site 930170006343 Excalibur calcium-binding domain; Region: Excalibur; smart00894 930170006344 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 930170006345 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 930170006346 PGAP1-like protein; Region: PGAP1; pfam07819 930170006347 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 930170006348 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 930170006349 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 930170006350 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 930170006351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170006352 Zn2+ binding site [ion binding]; other site 930170006353 Mg2+ binding site [ion binding]; other site 930170006354 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 930170006355 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170006356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170006357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170006358 ABC transporter; Region: ABC_tran_2; pfam12848 930170006359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170006360 Bax inhibitor 1 like; Region: BaxI_1; cl17691 930170006361 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 930170006362 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930170006363 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930170006364 dimer interface [polypeptide binding]; other site 930170006365 ssDNA binding site [nucleotide binding]; other site 930170006366 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170006367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170006368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170006369 hypothetical protein; Provisional; Region: PRK06753 930170006370 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930170006371 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 930170006372 Virulence factor; Region: Virulence_fact; pfam13769 930170006373 HEAT repeats; Region: HEAT_2; pfam13646 930170006374 HEAT repeats; Region: HEAT_2; pfam13646 930170006375 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 930170006376 Protein of unknown function, DUF393; Region: DUF393; pfam04134 930170006377 Disulphide isomerase; Region: Disulph_isomer; pfam06491 930170006378 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 930170006379 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 930170006380 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 930170006381 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 930170006382 active site 930170006383 HIGH motif; other site 930170006384 KMSK motif region; other site 930170006385 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 930170006386 tRNA binding surface [nucleotide binding]; other site 930170006387 anticodon binding site; other site 930170006388 potential frameshift: common BLAST hit: gi|301053708|ref|YP_003791919.1| methyltransferase 930170006389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006390 binding surface 930170006391 TPR motif; other site 930170006392 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930170006393 putative active site [active] 930170006394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006395 binding surface 930170006396 TPR motif; other site 930170006397 TPR repeat; Region: TPR_11; pfam13414 930170006398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006399 binding surface 930170006400 TPR motif; other site 930170006401 Tetratricopeptide repeat; Region: TPR_16; pfam13432 930170006402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006403 binding surface 930170006404 TPR motif; other site 930170006405 TPR repeat; Region: TPR_11; pfam13414 930170006406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006407 TPR motif; other site 930170006408 TPR repeat; Region: TPR_11; pfam13414 930170006409 binding surface 930170006410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006411 binding surface 930170006412 TPR motif; other site 930170006413 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170006414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006415 binding surface 930170006416 TPR motif; other site 930170006417 TPR repeat; Region: TPR_11; pfam13414 930170006418 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 930170006419 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930170006420 HIGH motif; other site 930170006421 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930170006422 active site 930170006423 KMSKS motif; other site 930170006424 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 930170006425 tRNA binding surface [nucleotide binding]; other site 930170006426 anticodon binding site; other site 930170006427 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930170006428 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930170006429 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930170006430 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 930170006431 Zn binding site [ion binding]; other site 930170006432 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 930170006433 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930170006434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930170006435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930170006436 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 930170006437 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 930170006438 Dimer interface [polypeptide binding]; other site 930170006439 anticodon binding site; other site 930170006440 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 930170006441 homodimer interface [polypeptide binding]; other site 930170006442 motif 1; other site 930170006443 motif 2; other site 930170006444 active site 930170006445 motif 3; other site 930170006446 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 930170006447 metal ion-dependent adhesion site (MIDAS); other site 930170006448 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 930170006449 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 930170006450 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 930170006451 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930170006452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170006453 Walker A motif; other site 930170006454 ATP binding site [chemical binding]; other site 930170006455 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 930170006456 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 930170006457 active site 930170006458 ATP binding site [chemical binding]; other site 930170006459 substrate binding site [chemical binding]; other site 930170006460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006461 binding surface 930170006462 TPR motif; other site 930170006463 TPR repeat; Region: TPR_11; pfam13414 930170006464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006465 binding surface 930170006466 TPR motif; other site 930170006467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170006468 binding surface 930170006469 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170006470 TPR motif; other site 930170006471 Protein of unknown function (DUF975); Region: DUF975; cl10504 930170006472 SseB protein; Region: SseB; cl06279 930170006473 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 930170006474 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 930170006475 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 930170006476 Protein of unknown function, DUF600; Region: DUF600; pfam04634 930170006477 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 930170006478 Protein of unknown function, DUF600; Region: DUF600; pfam04634 930170006479 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 930170006480 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 930170006481 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 930170006482 Na2 binding site [ion binding]; other site 930170006483 putative substrate binding site 1 [chemical binding]; other site 930170006484 Na binding site 1 [ion binding]; other site 930170006485 putative substrate binding site 2 [chemical binding]; other site 930170006486 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170006487 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 930170006488 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 930170006489 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930170006490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170006491 motif II; other site 930170006492 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 930170006493 fructuronate transporter; Provisional; Region: PRK10034; cl15264 930170006494 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930170006495 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 930170006496 active site 930170006497 NAD binding site [chemical binding]; other site 930170006498 metal binding site [ion binding]; metal-binding site 930170006499 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 930170006500 aspartate racemase; Region: asp_race; TIGR00035 930170006501 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 930170006502 homodimer interaction site [polypeptide binding]; other site 930170006503 cofactor binding site; other site 930170006504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170006505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006506 Coenzyme A binding pocket [chemical binding]; other site 930170006507 hypothetical protein; Validated; Region: PRK06769 930170006508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170006509 active site 930170006510 motif I; other site 930170006511 motif II; other site 930170006512 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170006513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006514 Coenzyme A binding pocket [chemical binding]; other site 930170006515 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170006516 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170006517 Walker A/P-loop; other site 930170006518 ATP binding site [chemical binding]; other site 930170006519 Q-loop/lid; other site 930170006520 ABC transporter signature motif; other site 930170006521 Walker B; other site 930170006522 D-loop; other site 930170006523 H-loop/switch region; other site 930170006524 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 930170006525 YpjP-like protein; Region: YpjP; pfam14005 930170006526 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930170006527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170006528 motif II; other site 930170006529 hypothetical protein; Provisional; Region: PRK06724 930170006530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170006531 active site 930170006532 metal binding site [ion binding]; metal-binding site 930170006533 Phosphotransferase enzyme family; Region: APH; pfam01636 930170006534 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930170006535 active site 930170006536 substrate binding site [chemical binding]; other site 930170006537 ATP binding site [chemical binding]; other site 930170006538 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 930170006539 Active site serine [active] 930170006540 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170006541 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170006542 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 930170006543 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 930170006544 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 930170006545 thymidylate synthase; Region: thym_sym; TIGR03284 930170006546 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 930170006547 dimerization interface [polypeptide binding]; other site 930170006548 active site 930170006549 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930170006550 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 930170006551 folate binding site [chemical binding]; other site 930170006552 NADP+ binding site [chemical binding]; other site 930170006553 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 930170006554 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170006555 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 930170006556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170006557 azoreductase; Reviewed; Region: PRK00170 930170006558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170006559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930170006560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930170006561 putative acyl-acceptor binding pocket; other site 930170006562 Haemolysin-III related; Region: HlyIII; cl03831 930170006563 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 930170006564 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 930170006565 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 930170006566 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 930170006567 EDD domain protein, DegV family; Region: DegV; TIGR00762 930170006568 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930170006569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 930170006570 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 930170006571 Probable transposase; Region: OrfB_IS605; pfam01385 930170006572 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170006573 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930170006574 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 930170006575 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 930170006576 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 930170006577 Cu(I) binding site [ion binding]; other site 930170006578 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 930170006579 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 930170006580 putative dimer interface [polypeptide binding]; other site 930170006581 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 930170006582 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 930170006583 active site 930170006584 dimer interface [polypeptide binding]; other site 930170006585 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 930170006586 Ligand Binding Site [chemical binding]; other site 930170006587 Molecular Tunnel; other site 930170006588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170006589 potential frameshift: common BLAST hit: gi|301053784|ref|YP_003791995.1| PAP2 family phosphatase 930170006590 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170006591 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 930170006592 siderophore binding site; other site 930170006593 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930170006594 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 930170006595 homodimer interface [polypeptide binding]; other site 930170006596 substrate-cofactor binding pocket; other site 930170006597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170006598 catalytic residue [active] 930170006599 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 930170006600 FMN binding site [chemical binding]; other site 930170006601 dimer interface [polypeptide binding]; other site 930170006602 Isochorismatase family; Region: Isochorismatase; pfam00857 930170006603 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 930170006604 catalytic triad [active] 930170006605 conserved cis-peptide bond; other site 930170006606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 930170006607 nudix motif; other site 930170006608 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 930170006609 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 930170006610 putative dimer interface [polypeptide binding]; other site 930170006611 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 930170006612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 930170006613 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930170006614 GAF domain; Region: GAF; pfam01590 930170006615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170006616 Histidine kinase; Region: HisKA_3; pfam07730 930170006617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170006618 ATP binding site [chemical binding]; other site 930170006619 Mg2+ binding site [ion binding]; other site 930170006620 G-X-G motif; other site 930170006621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170006622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170006623 active site 930170006624 phosphorylation site [posttranslational modification] 930170006625 intermolecular recognition site; other site 930170006626 dimerization interface [polypeptide binding]; other site 930170006627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170006628 DNA binding residues [nucleotide binding] 930170006629 dimerization interface [polypeptide binding]; other site 930170006630 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 930170006631 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 930170006632 NAD binding site [chemical binding]; other site 930170006633 substrate binding site [chemical binding]; other site 930170006634 catalytic Zn binding site [ion binding]; other site 930170006635 tetramer interface [polypeptide binding]; other site 930170006636 structural Zn binding site [ion binding]; other site 930170006637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170006638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170006639 dimer interface [polypeptide binding]; other site 930170006640 conserved gate region; other site 930170006641 ABC-ATPase subunit interface; other site 930170006642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170006643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170006644 dimer interface [polypeptide binding]; other site 930170006645 conserved gate region; other site 930170006646 putative PBP binding loops; other site 930170006647 ABC-ATPase subunit interface; other site 930170006648 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170006649 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170006650 Erythromycin esterase; Region: Erythro_esteras; pfam05139 930170006651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930170006652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930170006653 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170006654 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170006655 active site 930170006656 Predicted flavoprotein [General function prediction only]; Region: COG0431 930170006657 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170006658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006659 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170006660 putative substrate translocation pore; other site 930170006661 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930170006662 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930170006663 putative active site [active] 930170006664 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 930170006665 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 930170006666 Walker A/P-loop; other site 930170006667 ATP binding site [chemical binding]; other site 930170006668 Q-loop/lid; other site 930170006669 ABC transporter signature motif; other site 930170006670 Walker B; other site 930170006671 D-loop; other site 930170006672 H-loop/switch region; other site 930170006673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170006674 dimer interface [polypeptide binding]; other site 930170006675 conserved gate region; other site 930170006676 ABC-ATPase subunit interface; other site 930170006677 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930170006678 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 930170006679 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 930170006680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930170006681 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 930170006682 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930170006683 DNA binding residues [nucleotide binding] 930170006684 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930170006685 Domain of unknown function DUF21; Region: DUF21; pfam01595 930170006686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930170006687 Transporter associated domain; Region: CorC_HlyC; smart01091 930170006688 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 930170006689 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930170006690 NAD(P) binding site [chemical binding]; other site 930170006691 catalytic residues [active] 930170006692 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 930170006693 Histidine kinase N terminal; Region: HisK_N; pfam09385 930170006694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170006695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170006696 dimer interface [polypeptide binding]; other site 930170006697 phosphorylation site [posttranslational modification] 930170006698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170006699 ATP binding site [chemical binding]; other site 930170006700 Mg2+ binding site [ion binding]; other site 930170006701 G-X-G motif; other site 930170006702 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 930170006703 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 930170006704 hypothetical protein; Provisional; Region: PRK06917 930170006705 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170006706 inhibitor-cofactor binding pocket; inhibition site 930170006707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170006708 catalytic residue [active] 930170006709 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 930170006710 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 930170006711 acetylornithine deacetylase; Validated; Region: PRK06915 930170006712 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 930170006713 metal binding site [ion binding]; metal-binding site 930170006714 dimer interface [polypeptide binding]; other site 930170006715 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 930170006716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170006717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 930170006718 PAS fold; Region: PAS_4; pfam08448 930170006719 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 930170006720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170006721 Walker A motif; other site 930170006722 ATP binding site [chemical binding]; other site 930170006723 Walker B motif; other site 930170006724 arginine finger; other site 930170006725 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930170006726 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 930170006727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170006728 FeS/SAM binding site; other site 930170006729 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 930170006730 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 930170006731 toxin interface [polypeptide binding]; other site 930170006732 Zn binding site [ion binding]; other site 930170006733 hypothetical protein; Provisional; Region: PRK13672 930170006734 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 930170006735 YozD-like protein; Region: YozD; pfam14162 930170006736 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930170006737 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930170006738 active site 930170006739 ATP binding site [chemical binding]; other site 930170006740 substrate binding site [chemical binding]; other site 930170006741 activation loop (A-loop); other site 930170006742 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 930170006743 SpoOM protein; Region: Spo0M; pfam07070 930170006744 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930170006745 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930170006746 active site 930170006747 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930170006748 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 930170006749 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170006750 catalytic residues [active] 930170006751 Terminase small subunit; Region: Terminase_2; cl01513 930170006752 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 930170006753 CHRD domain; Region: CHRD; pfam07452 930170006754 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 930170006755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170006756 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 930170006757 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 930170006758 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 930170006759 C1q domain; Region: C1q; cl17543 930170006760 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 930170006761 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930170006762 YolD-like protein; Region: YolD; pfam08863 930170006763 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 930170006764 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 930170006765 Transglycosylase; Region: Transgly; pfam00912 930170006766 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930170006767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170006770 putative substrate translocation pore; other site 930170006771 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 930170006772 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 930170006773 dimer interface [polypeptide binding]; other site 930170006774 Citrate synthase; Region: Citrate_synt; pfam00285 930170006775 active site 930170006776 coenzyme A binding site [chemical binding]; other site 930170006777 citrylCoA binding site [chemical binding]; other site 930170006778 oxalacetate/citrate binding site [chemical binding]; other site 930170006779 catalytic triad [active] 930170006780 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 930170006781 2-methylcitrate dehydratase; Region: prpD; TIGR02330 930170006782 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 930170006783 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 930170006784 tetramer interface [polypeptide binding]; other site 930170006785 active site 930170006786 Mg2+/Mn2+ binding site [ion binding]; other site 930170006787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930170006788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930170006789 active site 930170006790 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 930170006791 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930170006792 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 930170006793 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 930170006794 tetrameric interface [polypeptide binding]; other site 930170006795 NAD binding site [chemical binding]; other site 930170006796 catalytic residues [active] 930170006797 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 930170006798 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 930170006799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930170006800 substrate binding site [chemical binding]; other site 930170006801 oxyanion hole (OAH) forming residues; other site 930170006802 trimer interface [polypeptide binding]; other site 930170006803 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 930170006804 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 930170006805 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 930170006806 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930170006807 active site 930170006808 metal binding site [ion binding]; metal-binding site 930170006809 DNA binding site [nucleotide binding] 930170006810 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 930170006811 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 930170006812 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 930170006813 Walker A/P-loop; other site 930170006814 ATP binding site [chemical binding]; other site 930170006815 Q-loop/lid; other site 930170006816 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 930170006817 ABC transporter signature motif; other site 930170006818 Walker B; other site 930170006819 D-loop; other site 930170006820 H-loop/switch region; other site 930170006821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170006822 dimerization interface [polypeptide binding]; other site 930170006823 putative DNA binding site [nucleotide binding]; other site 930170006824 putative Zn2+ binding site [ion binding]; other site 930170006825 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 930170006826 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 930170006827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006828 putative substrate translocation pore; other site 930170006829 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 930170006830 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 930170006831 putative NAD(P) binding site [chemical binding]; other site 930170006832 active site 930170006833 isochorismate synthase DhbC; Validated; Region: PRK06923 930170006834 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930170006835 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 930170006836 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 930170006837 acyl-activating enzyme (AAE) consensus motif; other site 930170006838 active site 930170006839 AMP binding site [chemical binding]; other site 930170006840 substrate binding site [chemical binding]; other site 930170006841 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 930170006842 hydrophobic substrate binding pocket; other site 930170006843 Isochorismatase family; Region: Isochorismatase; pfam00857 930170006844 active site 930170006845 conserved cis-peptide bond; other site 930170006846 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 930170006847 Condensation domain; Region: Condensation; pfam00668 930170006848 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170006849 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 930170006850 acyl-activating enzyme (AAE) consensus motif; other site 930170006851 AMP binding site [chemical binding]; other site 930170006852 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170006853 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 930170006854 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 930170006855 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170006856 acyl-activating enzyme (AAE) consensus motif; other site 930170006857 AMP binding site [chemical binding]; other site 930170006858 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170006859 MbtH-like protein; Region: MbtH; cl01279 930170006860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006861 putative transporter; Provisional; Region: PRK10504 930170006862 putative substrate translocation pore; other site 930170006863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006864 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 930170006865 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 930170006866 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 930170006867 IHF dimer interface [polypeptide binding]; other site 930170006868 IHF - DNA interface [nucleotide binding]; other site 930170006869 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 930170006870 DinB family; Region: DinB; cl17821 930170006871 DinB superfamily; Region: DinB_2; pfam12867 930170006872 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 930170006873 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 930170006874 active site 930170006875 catalytic triad [active] 930170006876 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170006877 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 930170006878 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930170006879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170006880 RNA binding surface [nucleotide binding]; other site 930170006881 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 930170006882 probable active site [active] 930170006883 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 930170006884 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 930170006885 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930170006886 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 930170006887 active site 930170006888 dimer interface [polypeptide binding]; other site 930170006889 motif 1; other site 930170006890 motif 2; other site 930170006891 motif 3; other site 930170006892 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 930170006893 anticodon binding site; other site 930170006894 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170006895 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170006896 Walker A/P-loop; other site 930170006897 ATP binding site [chemical binding]; other site 930170006898 Q-loop/lid; other site 930170006899 ABC transporter signature motif; other site 930170006900 Walker B; other site 930170006901 D-loop; other site 930170006902 H-loop/switch region; other site 930170006903 FtsX-like permease family; Region: FtsX; pfam02687 930170006904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170006905 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 930170006906 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170006907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930170006909 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930170006910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170006911 dimer interface [polypeptide binding]; other site 930170006912 conserved gate region; other site 930170006913 ABC-ATPase subunit interface; other site 930170006914 pyruvate oxidase; Provisional; Region: PRK08611 930170006915 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 930170006916 PYR/PP interface [polypeptide binding]; other site 930170006917 dimer interface [polypeptide binding]; other site 930170006918 tetramer interface [polypeptide binding]; other site 930170006919 TPP binding site [chemical binding]; other site 930170006920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170006921 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 930170006922 TPP-binding site [chemical binding]; other site 930170006923 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 930170006924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170006925 S-adenosylmethionine binding site [chemical binding]; other site 930170006926 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 930170006927 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 930170006928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170006929 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 930170006930 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 930170006931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930170006932 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170006933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170006934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170006935 MMPL family; Region: MMPL; pfam03176 930170006936 MMPL family; Region: MMPL; pfam03176 930170006937 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 930170006938 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 930170006939 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 930170006940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170006941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170006943 Coenzyme A binding pocket [chemical binding]; other site 930170006944 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930170006945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 930170006946 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930170006947 putative acetyltransferase YhhY; Provisional; Region: PRK10140 930170006948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170006949 Coenzyme A binding pocket [chemical binding]; other site 930170006950 EamA-like transporter family; Region: EamA; pfam00892 930170006951 EamA-like transporter family; Region: EamA; pfam00892 930170006952 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930170006953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170006954 non-specific DNA binding site [nucleotide binding]; other site 930170006955 salt bridge; other site 930170006956 sequence-specific DNA binding site [nucleotide binding]; other site 930170006957 Cupin domain; Region: Cupin_2; pfam07883 930170006958 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 930170006959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170006960 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930170006961 protoporphyrinogen oxidase; Provisional; Region: PRK12416 930170006962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170006963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170006964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170006965 Cold-inducible protein YdjO; Region: YdjO; pfam14169 930170006966 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930170006967 DNA-binding site [nucleotide binding]; DNA binding site 930170006968 RNA-binding motif; other site 930170006969 CAAX protease self-immunity; Region: Abi; pfam02517 930170006970 AAA domain; Region: AAA_17; pfam13207 930170006971 AAA domain; Region: AAA_18; pfam13238 930170006972 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 930170006973 active site 930170006974 metal binding site [ion binding]; metal-binding site 930170006975 hypothetical protein; Provisional; Region: PRK06770 930170006976 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170006977 MarR family; Region: MarR_2; cl17246 930170006978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170006979 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930170006980 putative substrate translocation pore; other site 930170006981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170006982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170006983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170006984 dimerization interface [polypeptide binding]; other site 930170006985 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 930170006986 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930170006987 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930170006988 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 930170006989 active site 930170006990 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 930170006991 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 930170006992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170006993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170006994 dimerization interface [polypeptide binding]; other site 930170006995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 930170006996 MOSC domain; Region: MOSC; pfam03473 930170006997 3-alpha domain; Region: 3-alpha; pfam03475 930170006998 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 930170006999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007000 Coenzyme A binding pocket [chemical binding]; other site 930170007001 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 930170007002 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170007003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170007004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170007005 Walker A/P-loop; other site 930170007006 ATP binding site [chemical binding]; other site 930170007007 Q-loop/lid; other site 930170007008 ABC transporter signature motif; other site 930170007009 Walker B; other site 930170007010 D-loop; other site 930170007011 H-loop/switch region; other site 930170007012 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170007013 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170007014 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930170007015 Walker A/P-loop; other site 930170007016 ATP binding site [chemical binding]; other site 930170007017 Q-loop/lid; other site 930170007018 ABC transporter signature motif; other site 930170007019 Walker B; other site 930170007020 D-loop; other site 930170007021 H-loop/switch region; other site 930170007022 LysE type translocator; Region: LysE; cl00565 930170007023 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930170007024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170007025 non-specific DNA binding site [nucleotide binding]; other site 930170007026 salt bridge; other site 930170007027 sequence-specific DNA binding site [nucleotide binding]; other site 930170007028 Cupin domain; Region: Cupin_2; pfam07883 930170007029 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 930170007030 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 930170007031 BclB C-terminal domain; Region: exospore_TM; TIGR03721 930170007032 Cupin; Region: Cupin_1; smart00835 930170007033 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 930170007034 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 930170007035 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 930170007036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170007037 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 930170007038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170007039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170007040 DNA binding residues [nucleotide binding] 930170007041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170007042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007043 S-adenosylmethionine binding site [chemical binding]; other site 930170007044 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 930170007045 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 930170007046 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 930170007047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 930170007048 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930170007049 active site 930170007050 P-loop; other site 930170007051 phosphorylation site [posttranslational modification] 930170007052 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930170007053 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930170007054 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 930170007055 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 930170007056 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 930170007057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 930170007058 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 930170007059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170007060 catalytic residue [active] 930170007061 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 930170007062 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 930170007063 tetramer interface [polypeptide binding]; other site 930170007064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170007065 catalytic residue [active] 930170007066 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170007067 MarR family; Region: MarR; pfam01047 930170007068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170007070 putative substrate translocation pore; other site 930170007071 Uncharacterized conserved protein [Function unknown]; Region: COG3339 930170007072 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 930170007073 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 930170007074 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930170007075 ATP binding site [chemical binding]; other site 930170007076 Mg++ binding site [ion binding]; other site 930170007077 motif III; other site 930170007078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170007079 nucleotide binding region [chemical binding]; other site 930170007080 ATP-binding site [chemical binding]; other site 930170007081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170007082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170007083 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170007084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007085 putative substrate translocation pore; other site 930170007086 FtsX-like permease family; Region: FtsX; pfam02687 930170007087 FtsX-like permease family; Region: FtsX; pfam02687 930170007088 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170007089 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170007090 Walker A/P-loop; other site 930170007091 ATP binding site [chemical binding]; other site 930170007092 Q-loop/lid; other site 930170007093 ABC transporter signature motif; other site 930170007094 Walker B; other site 930170007095 D-loop; other site 930170007096 H-loop/switch region; other site 930170007097 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170007098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007099 S-adenosylmethionine binding site [chemical binding]; other site 930170007100 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930170007101 dimer interface [polypeptide binding]; other site 930170007102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170007103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007104 S-adenosylmethionine binding site [chemical binding]; other site 930170007105 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 930170007106 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 930170007107 dimer interface [polypeptide binding]; other site 930170007108 PYR/PP interface [polypeptide binding]; other site 930170007109 TPP binding site [chemical binding]; other site 930170007110 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170007111 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 930170007112 TPP-binding site [chemical binding]; other site 930170007113 dimer interface [polypeptide binding]; other site 930170007114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170007115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170007116 putative DNA binding site [nucleotide binding]; other site 930170007117 putative Zn2+ binding site [ion binding]; other site 930170007118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170007119 catalytic core [active] 930170007120 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 930170007121 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 930170007122 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 930170007123 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 930170007124 metal binding site [ion binding]; metal-binding site 930170007125 dimer interface [polypeptide binding]; other site 930170007126 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 930170007127 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 930170007128 trimer interface [polypeptide binding]; other site 930170007129 active site 930170007130 substrate binding site [chemical binding]; other site 930170007131 CoA binding site [chemical binding]; other site 930170007132 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 930170007133 active site 930170007134 catalytic triad [active] 930170007135 oxyanion hole [active] 930170007136 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 930170007137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170007138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170007139 DNA binding residues [nucleotide binding] 930170007140 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170007141 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170007142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170007143 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170007144 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170007145 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170007146 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170007147 beta-lactamase TEM; Provisional; Region: PRK15442 930170007148 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 930170007149 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930170007150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170007151 putative active site [active] 930170007152 putative metal binding site [ion binding]; other site 930170007153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170007154 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930170007155 Walker A/P-loop; other site 930170007156 ATP binding site [chemical binding]; other site 930170007157 Q-loop/lid; other site 930170007158 ABC transporter signature motif; other site 930170007159 Walker B; other site 930170007160 D-loop; other site 930170007161 H-loop/switch region; other site 930170007162 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930170007163 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930170007164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170007165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170007166 Protein of unknown function (DUF523); Region: DUF523; pfam04463 930170007167 Uncharacterized conserved protein [Function unknown]; Region: COG3272 930170007168 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 930170007169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930170007170 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 930170007171 FAD binding site [chemical binding]; other site 930170007172 homotetramer interface [polypeptide binding]; other site 930170007173 substrate binding pocket [chemical binding]; other site 930170007174 catalytic base [active] 930170007175 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 930170007176 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930170007177 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930170007178 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930170007179 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930170007180 carboxyltransferase (CT) interaction site; other site 930170007181 biotinylation site [posttranslational modification]; other site 930170007182 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 930170007183 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 930170007184 active site 930170007185 catalytic residues [active] 930170007186 metal binding site [ion binding]; metal-binding site 930170007187 enoyl-CoA hydratase; Provisional; Region: PRK07657 930170007188 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930170007189 substrate binding site [chemical binding]; other site 930170007190 oxyanion hole (OAH) forming residues; other site 930170007191 trimer interface [polypeptide binding]; other site 930170007192 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 930170007193 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930170007194 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930170007195 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 930170007196 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 930170007197 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 930170007198 acyl-activating enzyme (AAE) consensus motif; other site 930170007199 putative AMP binding site [chemical binding]; other site 930170007200 putative active site [active] 930170007201 putative CoA binding site [chemical binding]; other site 930170007202 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170007203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007204 Coenzyme A binding pocket [chemical binding]; other site 930170007205 hypothetical protein; Provisional; Region: PRK08233 930170007206 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 930170007207 active site 930170007208 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 930170007209 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170007210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170007211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170007212 dimer interface [polypeptide binding]; other site 930170007213 phosphorylation site [posttranslational modification] 930170007214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170007215 ATP binding site [chemical binding]; other site 930170007216 Mg2+ binding site [ion binding]; other site 930170007217 G-X-G motif; other site 930170007218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170007219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170007220 active site 930170007221 phosphorylation site [posttranslational modification] 930170007222 intermolecular recognition site; other site 930170007223 dimerization interface [polypeptide binding]; other site 930170007224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170007225 DNA binding site [nucleotide binding] 930170007226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170007227 Zn2+ binding site [ion binding]; other site 930170007228 Mg2+ binding site [ion binding]; other site 930170007229 Probable transposase; Region: OrfB_IS605; pfam01385 930170007230 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170007231 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170007232 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 930170007233 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 930170007234 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 930170007235 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930170007236 NAD binding site [chemical binding]; other site 930170007237 substrate binding site [chemical binding]; other site 930170007238 putative active site [active] 930170007239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170007240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007241 Coenzyme A binding pocket [chemical binding]; other site 930170007242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007243 Coenzyme A binding pocket [chemical binding]; other site 930170007244 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930170007245 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930170007246 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930170007247 active site 930170007248 Zn binding site [ion binding]; other site 930170007249 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930170007250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 930170007251 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 930170007252 putative hydrophobic ligand binding site [chemical binding]; other site 930170007253 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 930170007254 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170007255 DNA binding residues [nucleotide binding] 930170007256 drug binding residues [chemical binding]; other site 930170007257 dimer interface [polypeptide binding]; other site 930170007258 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 930170007259 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170007260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007261 putative substrate translocation pore; other site 930170007262 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170007263 nudix motif; other site 930170007264 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 930170007265 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930170007266 Phosphotransferase enzyme family; Region: APH; pfam01636 930170007267 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930170007268 active site 930170007269 substrate binding site [chemical binding]; other site 930170007270 ATP binding site [chemical binding]; other site 930170007271 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170007272 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170007273 Phosphotransferase enzyme family; Region: APH; pfam01636 930170007274 active site 930170007275 substrate binding site [chemical binding]; other site 930170007276 ATP binding site [chemical binding]; other site 930170007277 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 930170007278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170007279 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 930170007280 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 930170007281 active site 930170007282 Zn binding site [ion binding]; other site 930170007283 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 930170007284 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170007285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170007286 DNA-binding site [nucleotide binding]; DNA binding site 930170007287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170007288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170007289 homodimer interface [polypeptide binding]; other site 930170007290 catalytic residue [active] 930170007291 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 930170007292 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 930170007293 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 930170007294 Predicted membrane protein [Function unknown]; Region: COG2323 930170007295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007296 S-adenosylmethionine binding site [chemical binding]; other site 930170007297 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170007298 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930170007299 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 930170007300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007301 S-adenosylmethionine binding site [chemical binding]; other site 930170007302 potential frameshift: common BLAST hit: gi|42781671|ref|NP_978918.1| regucalcin family protein 930170007303 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 930170007304 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 930170007305 active site 930170007306 HIGH motif; other site 930170007307 KMSKS motif; other site 930170007308 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 930170007309 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 930170007310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170007312 active site 930170007313 phosphorylation site [posttranslational modification] 930170007314 intermolecular recognition site; other site 930170007315 dimerization interface [polypeptide binding]; other site 930170007316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170007317 DNA binding site [nucleotide binding] 930170007318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170007319 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 930170007320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170007321 ATP binding site [chemical binding]; other site 930170007322 Mg2+ binding site [ion binding]; other site 930170007323 G-X-G motif; other site 930170007324 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 930170007325 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170007326 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170007327 ABC transporter; Region: ABC_tran_2; pfam12848 930170007328 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170007329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007330 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170007331 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 930170007332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170007333 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170007334 Walker A/P-loop; other site 930170007335 ATP binding site [chemical binding]; other site 930170007336 Q-loop/lid; other site 930170007337 ABC transporter signature motif; other site 930170007338 Walker B; other site 930170007339 D-loop; other site 930170007340 H-loop/switch region; other site 930170007341 FtsX-like permease family; Region: FtsX; pfam02687 930170007342 hypothetical protein; Provisional; Region: PRK06760 930170007343 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 930170007344 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 930170007345 homoserine dehydrogenase; Validated; Region: PRK06813 930170007346 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 930170007347 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170007348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170007349 DNA-binding site [nucleotide binding]; DNA binding site 930170007350 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170007351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170007352 homodimer interface [polypeptide binding]; other site 930170007353 catalytic residue [active] 930170007354 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 930170007355 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 930170007356 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930170007357 Putative transcription activator [Transcription]; Region: TenA; COG0819 930170007358 potential frameshift: common BLAST hit: gi|152976319|ref|YP_001375836.1| FliA/WhiG family RNA polymerase sigma factor 930170007359 HTH-like domain; Region: HTH_21; pfam13276 930170007360 Integrase core domain; Region: rve; pfam00665 930170007361 Integrase core domain; Region: rve_2; pfam13333 930170007362 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170007363 Winged helix-turn helix; Region: HTH_29; pfam13551 930170007364 Transposase; Region: HTH_Tnp_1; cl17663 930170007365 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170007366 Winged helix-turn helix; Region: HTH_29; pfam13551 930170007367 YopX protein; Region: YopX; pfam09643 930170007368 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 930170007369 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 930170007370 potential frameshift: common BLAST hit: gi|118445180|ref|YP_891149.1| phage terminase small subunit 930170007371 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 930170007372 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 930170007373 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 930170007374 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 930170007375 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 930170007376 Protein of unknown function; Region: DUF3658; pfam12395 930170007377 Cytochrome P450; Region: p450; cl12078 930170007378 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 930170007379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007380 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170007381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007382 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 930170007383 trimer interface [polypeptide binding]; other site 930170007384 active site 930170007385 substrate binding site [chemical binding]; other site 930170007386 CoA binding site [chemical binding]; other site 930170007387 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 930170007388 DinB superfamily; Region: DinB_2; pfam12867 930170007389 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 930170007390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170007391 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170007392 active site 930170007393 motif I; other site 930170007394 motif II; other site 930170007395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170007396 PAS domain S-box; Region: sensory_box; TIGR00229 930170007397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170007398 putative active site [active] 930170007399 heme pocket [chemical binding]; other site 930170007400 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930170007401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170007402 dimer interface [polypeptide binding]; other site 930170007403 phosphorylation site [posttranslational modification] 930170007404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170007405 ATP binding site [chemical binding]; other site 930170007406 Mg2+ binding site [ion binding]; other site 930170007407 G-X-G motif; other site 930170007408 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170007409 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170007410 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170007411 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170007412 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 930170007413 glycosyltransferase, MGT family; Region: MGT; TIGR01426 930170007414 active site 930170007415 TDP-binding site; other site 930170007416 acceptor substrate-binding pocket; other site 930170007417 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 930170007418 aspartate racemase; Region: asp_race; TIGR00035 930170007419 hypothetical protein; Provisional; Region: PRK13661 930170007420 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 930170007421 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930170007422 Walker A/P-loop; other site 930170007423 ATP binding site [chemical binding]; other site 930170007424 Q-loop/lid; other site 930170007425 ABC transporter signature motif; other site 930170007426 Walker B; other site 930170007427 D-loop; other site 930170007428 H-loop/switch region; other site 930170007429 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 930170007430 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930170007431 Walker A/P-loop; other site 930170007432 ATP binding site [chemical binding]; other site 930170007433 Q-loop/lid; other site 930170007434 ABC transporter signature motif; other site 930170007435 Walker B; other site 930170007436 D-loop; other site 930170007437 H-loop/switch region; other site 930170007438 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930170007439 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930170007440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170007441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170007442 dimer interface [polypeptide binding]; other site 930170007443 phosphorylation site [posttranslational modification] 930170007444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170007445 ATP binding site [chemical binding]; other site 930170007446 Mg2+ binding site [ion binding]; other site 930170007447 G-X-G motif; other site 930170007448 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 930170007449 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 930170007450 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930170007451 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930170007452 NAD(P) binding site [chemical binding]; other site 930170007453 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 930170007454 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930170007455 active site 930170007456 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170007457 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170007458 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170007459 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 930170007460 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 930170007461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007462 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170007463 putative substrate translocation pore; other site 930170007464 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170007465 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170007466 putative acetyltransferase; Provisional; Region: PRK03624 930170007467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007468 Coenzyme A binding pocket [chemical binding]; other site 930170007469 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 930170007470 EDD domain protein, DegV family; Region: DegV; TIGR00762 930170007471 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930170007472 Putative amidotransferase; Region: DUF4066; pfam13278 930170007473 conserved cys residue [active] 930170007474 Predicted transcriptional regulator [Transcription]; Region: COG2378 930170007475 HTH domain; Region: HTH_11; pfam08279 930170007476 WYL domain; Region: WYL; pfam13280 930170007477 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 930170007478 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 930170007479 conserved cys residue [active] 930170007480 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 930170007481 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170007482 DNA binding residues [nucleotide binding] 930170007483 putative dimer interface [polypeptide binding]; other site 930170007484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007485 S-adenosylmethionine binding site [chemical binding]; other site 930170007486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170007488 putative substrate translocation pore; other site 930170007489 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170007490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007491 putative substrate translocation pore; other site 930170007492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007493 Coenzyme A binding pocket [chemical binding]; other site 930170007494 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930170007495 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 930170007496 active site 930170007497 catalytic site [active] 930170007498 metal binding site [ion binding]; metal-binding site 930170007499 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 930170007500 active site 930170007501 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 930170007502 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170007503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170007504 DNA-binding site [nucleotide binding]; DNA binding site 930170007505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170007506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170007507 homodimer interface [polypeptide binding]; other site 930170007508 catalytic residue [active] 930170007509 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170007510 EamA-like transporter family; Region: EamA; pfam00892 930170007511 EamA-like transporter family; Region: EamA; pfam00892 930170007512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007513 Coenzyme A binding pocket [chemical binding]; other site 930170007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 930170007515 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930170007516 nudix motif; other site 930170007517 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 930170007518 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 930170007519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007520 putative substrate translocation pore; other site 930170007521 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170007522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007523 Coenzyme A binding pocket [chemical binding]; other site 930170007524 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170007525 nudix motif; other site 930170007526 DNA polymerase III subunit beta; Validated; Region: PRK06673 930170007527 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 930170007528 putative DNA binding surface [nucleotide binding]; other site 930170007529 dimer interface [polypeptide binding]; other site 930170007530 beta-clamp/clamp loader binding surface; other site 930170007531 beta-clamp/translesion DNA polymerase binding surface; other site 930170007532 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 930170007533 putative active site [active] 930170007534 nucleotide binding site [chemical binding]; other site 930170007535 nudix motif; other site 930170007536 putative metal binding site [ion binding]; other site 930170007537 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170007538 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930170007539 translation initiation factor IF-2; Provisional; Region: PRK14845 930170007540 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 930170007541 homotrimer interaction site [polypeptide binding]; other site 930170007542 putative active site [active] 930170007543 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 930170007544 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 930170007545 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 930170007546 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 930170007547 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 930170007548 YxiJ-like protein; Region: YxiJ; pfam14176 930170007549 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 930170007550 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 930170007551 active site 930170007552 nucleophile elbow; other site 930170007553 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 930170007554 pentamer interface [polypeptide binding]; other site 930170007555 dodecaamer interface [polypeptide binding]; other site 930170007556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007558 Coenzyme A binding pocket [chemical binding]; other site 930170007559 metal-dependent hydrolase; Provisional; Region: PRK13291 930170007560 DinB superfamily; Region: DinB_2; pfam12867 930170007561 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007562 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170007563 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 930170007564 Bacitracin resistance protein BacA; Region: BacA; pfam02673 930170007565 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930170007566 GIY-YIG motif/motif A; other site 930170007567 active site 930170007568 catalytic site [active] 930170007569 putative DNA binding site [nucleotide binding]; other site 930170007570 metal binding site [ion binding]; metal-binding site 930170007571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007573 Coenzyme A binding pocket [chemical binding]; other site 930170007574 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 930170007575 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 930170007576 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 930170007577 active site 930170007578 ATP binding site [chemical binding]; other site 930170007579 substrate binding site [chemical binding]; other site 930170007580 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 930170007581 nudix motif; other site 930170007582 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930170007583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170007584 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930170007585 N-acetyltransferase; Region: Acetyltransf_2; cl00949 930170007586 MepB protein; Region: MepB; pfam08877 930170007587 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 930170007588 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 930170007589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170007590 motif II; other site 930170007591 DinB superfamily; Region: DinB_2; pfam12867 930170007592 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 930170007593 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 930170007594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170007595 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930170007596 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 930170007597 active site 930170007598 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 930170007599 carbohydrate binding site [chemical binding]; other site 930170007600 pullulanase, type I; Region: pulA_typeI; TIGR02104 930170007601 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 930170007602 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 930170007603 Ca binding site [ion binding]; other site 930170007604 active site 930170007605 catalytic site [active] 930170007606 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 930170007607 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930170007608 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930170007609 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930170007610 active site 930170007611 Zn binding site [ion binding]; other site 930170007612 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930170007613 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 930170007614 SecY translocase; Region: SecY; pfam00344 930170007615 hypothetical protein; Validated; Region: PRK06672 930170007616 DnaA N-terminal domain; Region: DnaA_N; pfam11638 930170007617 DnaA N-terminal domain; Region: DnaA_N; pfam11638 930170007618 DnaA N-terminal domain; Region: DnaA_N; pfam11638 930170007619 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 930170007620 EamA-like transporter family; Region: EamA; pfam00892 930170007621 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170007622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170007623 DNA-binding site [nucleotide binding]; DNA binding site 930170007624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170007625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170007626 homodimer interface [polypeptide binding]; other site 930170007627 catalytic residue [active] 930170007628 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170007629 TAP-like protein; Region: Abhydrolase_4; pfam08386 930170007630 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 930170007631 Mg binding site [ion binding]; other site 930170007632 nucleotide binding site [chemical binding]; other site 930170007633 putative protofilament interface [polypeptide binding]; other site 930170007634 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 930170007635 Predicted membrane protein [Function unknown]; Region: COG4129 930170007636 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 930170007637 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170007638 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 930170007639 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 930170007640 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 930170007641 germination protein YpeB; Region: spore_YpeB; TIGR02889 930170007642 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 930170007643 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 930170007644 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 930170007645 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 930170007646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170007647 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170007648 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 930170007649 arylformamidase; Region: trp_arylform; TIGR03035 930170007650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930170007651 kynureninase; Region: kynureninase; TIGR01814 930170007652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170007653 catalytic residue [active] 930170007654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170007655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170007656 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930170007657 nudix motif; other site 930170007658 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 930170007659 hydrophobic ligand binding site; other site 930170007660 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 930170007661 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 930170007662 GAF domain; Region: GAF; pfam01590 930170007663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170007664 Walker A motif; other site 930170007665 ATP binding site [chemical binding]; other site 930170007666 Walker B motif; other site 930170007667 arginine finger; other site 930170007668 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930170007669 NIPSNAP; Region: NIPSNAP; pfam07978 930170007670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 930170007671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007672 Coenzyme A binding pocket [chemical binding]; other site 930170007673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930170007674 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 930170007675 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930170007676 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 930170007677 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 930170007678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170007679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170007680 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930170007681 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930170007682 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930170007683 E3 interaction surface; other site 930170007684 lipoyl attachment site [posttranslational modification]; other site 930170007685 e3 binding domain; Region: E3_binding; pfam02817 930170007686 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930170007687 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930170007688 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930170007689 alpha subunit interface [polypeptide binding]; other site 930170007690 TPP binding site [chemical binding]; other site 930170007691 heterodimer interface [polypeptide binding]; other site 930170007692 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170007693 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 930170007694 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930170007695 tetramer interface [polypeptide binding]; other site 930170007696 TPP-binding site [chemical binding]; other site 930170007697 heterodimer interface [polypeptide binding]; other site 930170007698 phosphorylation loop region [posttranslational modification] 930170007699 DinB superfamily; Region: DinB_2; pfam12867 930170007700 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 930170007701 short chain dehydrogenase; Provisional; Region: PRK06914 930170007702 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 930170007703 NADP binding site [chemical binding]; other site 930170007704 active site 930170007705 steroid binding site; other site 930170007706 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 930170007707 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 930170007708 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 930170007709 nudix motif; other site 930170007710 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 930170007711 Protein phosphatase 2C; Region: PP2C_2; pfam13672 930170007712 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 930170007713 nucleotide binding site/active site [active] 930170007714 HIT family signature motif; other site 930170007715 catalytic residue [active] 930170007716 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 930170007717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170007718 dimer interface [polypeptide binding]; other site 930170007719 conserved gate region; other site 930170007720 putative PBP binding loops; other site 930170007721 ABC-ATPase subunit interface; other site 930170007722 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 930170007723 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 930170007724 Walker A/P-loop; other site 930170007725 ATP binding site [chemical binding]; other site 930170007726 Q-loop/lid; other site 930170007727 ABC transporter signature motif; other site 930170007728 Walker B; other site 930170007729 D-loop; other site 930170007730 H-loop/switch region; other site 930170007731 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 930170007732 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 930170007733 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930170007734 Clp protease; Region: CLP_protease; pfam00574 930170007735 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930170007736 oligomer interface [polypeptide binding]; other site 930170007737 active site residues [active] 930170007738 RNA polymerase factor sigma-70; Validated; Region: PRK06704 930170007739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170007740 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 930170007741 DNA binding residues [nucleotide binding] 930170007742 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 930170007743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930170007744 catalytic loop [active] 930170007745 iron binding site [ion binding]; other site 930170007746 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 930170007747 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170007748 active site 930170007749 dimer interface [polypeptide binding]; other site 930170007750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007751 Coenzyme A binding pocket [chemical binding]; other site 930170007752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 930170007753 Chitin binding domain; Region: Chitin_bind_3; pfam03067 930170007754 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930170007755 Interdomain contacts; other site 930170007756 Cytokine receptor motif; other site 930170007757 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930170007758 Interdomain contacts; other site 930170007759 Cytokine receptor motif; other site 930170007760 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930170007761 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 930170007762 glycosyltransferase, MGT family; Region: MGT; TIGR01426 930170007763 active site 930170007764 TDP-binding site; other site 930170007765 acceptor substrate-binding pocket; other site 930170007766 homodimer interface [polypeptide binding]; other site 930170007767 Uncharacterized conserved protein [Function unknown]; Region: COG1262 930170007768 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 930170007769 topology modulation protein; Reviewed; Region: PRK08118 930170007770 AAA domain; Region: AAA_17; pfam13207 930170007771 Phosphotransferase enzyme family; Region: APH; pfam01636 930170007772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930170007773 substrate binding site [chemical binding]; other site 930170007774 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 930170007775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007776 S-adenosylmethionine binding site [chemical binding]; other site 930170007777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 930170007778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007779 Coenzyme A binding pocket [chemical binding]; other site 930170007780 S-layer homology domain; Region: SLH; pfam00395 930170007781 S-layer homology domain; Region: SLH; pfam00395 930170007782 S-layer homology domain; Region: SLH; pfam00395 930170007783 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 930170007784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170007785 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 930170007786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007787 Coenzyme A binding pocket [chemical binding]; other site 930170007788 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 930170007789 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 930170007790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007791 Coenzyme A binding pocket [chemical binding]; other site 930170007792 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170007793 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170007794 Protein of unknown function (DUF952); Region: DUF952; pfam06108 930170007795 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 930170007796 Part of AAA domain; Region: AAA_19; pfam13245 930170007797 Family description; Region: UvrD_C_2; pfam13538 930170007798 CAAX protease self-immunity; Region: Abi; pfam02517 930170007799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007800 S-adenosylmethionine binding site [chemical binding]; other site 930170007801 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 930170007802 putative active site pocket [active] 930170007803 dimerization interface [polypeptide binding]; other site 930170007804 putative catalytic residue [active] 930170007805 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 930170007806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170007807 ATP binding site [chemical binding]; other site 930170007808 putative Mg++ binding site [ion binding]; other site 930170007809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170007810 nucleotide binding region [chemical binding]; other site 930170007811 ATP-binding site [chemical binding]; other site 930170007812 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 930170007813 HRDC domain; Region: HRDC; pfam00570 930170007814 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 930170007815 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 930170007816 active site 930170007817 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 930170007818 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930170007819 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930170007820 active site 930170007821 metal binding site [ion binding]; metal-binding site 930170007822 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 930170007823 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 930170007824 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 930170007825 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 930170007826 active site 930170007827 Zn binding site [ion binding]; other site 930170007828 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 930170007829 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 930170007830 DHHA2 domain; Region: DHHA2; pfam02833 930170007831 Chitin binding domain; Region: Chitin_bind_3; pfam03067 930170007832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170007833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007834 Coenzyme A binding pocket [chemical binding]; other site 930170007835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170007836 Zn2+ binding site [ion binding]; other site 930170007837 Mg2+ binding site [ion binding]; other site 930170007838 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 930170007839 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170007840 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 930170007841 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 930170007842 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930170007843 NAD(P) binding site [chemical binding]; other site 930170007844 catalytic residues [active] 930170007845 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 930170007846 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 930170007847 inhibitor site; inhibition site 930170007848 active site 930170007849 dimer interface [polypeptide binding]; other site 930170007850 catalytic residue [active] 930170007851 Proline racemase; Region: Pro_racemase; pfam05544 930170007852 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 930170007853 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 930170007854 Proline racemase; Region: Pro_racemase; pfam05544 930170007855 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930170007856 hydroxyglutarate oxidase; Provisional; Region: PRK11728 930170007857 PAS domain; Region: PAS; smart00091 930170007858 PAS domain; Region: PAS_9; pfam13426 930170007859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170007860 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930170007861 Walker A motif; other site 930170007862 ATP binding site [chemical binding]; other site 930170007863 Walker B motif; other site 930170007864 arginine finger; other site 930170007865 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930170007866 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930170007867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930170007868 catalytic loop [active] 930170007869 iron binding site [ion binding]; other site 930170007870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930170007871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170007872 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 930170007873 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 930170007874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170007876 potential frameshift: common BLAST hit: gi|301054367|ref|YP_003792578.1| HD superfamily phosphohydrolase 930170007877 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930170007878 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170007879 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 930170007880 DltD N-terminal region; Region: DltD_N; pfam04915 930170007881 DltD central region; Region: DltD_M; pfam04918 930170007882 DltD C-terminal region; Region: DltD_C; pfam04914 930170007883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170007885 Coenzyme A binding pocket [chemical binding]; other site 930170007886 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170007887 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170007888 peptide binding site [polypeptide binding]; other site 930170007889 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930170007890 NlpC/P60 family; Region: NLPC_P60; pfam00877 930170007891 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 930170007892 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 930170007893 active site 930170007894 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 930170007895 Septum formation initiator; Region: DivIC; pfam04977 930170007896 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 930170007897 DJ-1 family protein; Region: not_thiJ; TIGR01383 930170007898 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 930170007899 conserved cys residue [active] 930170007900 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 930170007901 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930170007902 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930170007903 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170007904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007905 S-adenosylmethionine binding site [chemical binding]; other site 930170007906 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 930170007907 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 930170007908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170007909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170007910 dimerization interface [polypeptide binding]; other site 930170007911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170007912 dimer interface [polypeptide binding]; other site 930170007913 phosphorylation site [posttranslational modification] 930170007914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170007915 ATP binding site [chemical binding]; other site 930170007916 Mg2+ binding site [ion binding]; other site 930170007917 G-X-G motif; other site 930170007918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170007919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170007920 active site 930170007921 phosphorylation site [posttranslational modification] 930170007922 intermolecular recognition site; other site 930170007923 dimerization interface [polypeptide binding]; other site 930170007924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170007925 DNA binding site [nucleotide binding] 930170007926 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170007927 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930170007928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170007929 motif II; other site 930170007930 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 930170007931 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 930170007932 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 930170007933 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 930170007934 Zn binding site [ion binding]; other site 930170007935 EDD domain protein, DegV family; Region: DegV; TIGR00762 930170007936 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930170007937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170007938 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 930170007939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170007940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170007942 putative substrate translocation pore; other site 930170007943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007944 putative substrate translocation pore; other site 930170007945 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 930170007946 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 930170007947 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 930170007948 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 930170007949 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 930170007950 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 930170007951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170007953 putative substrate translocation pore; other site 930170007954 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 930170007955 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 930170007956 active site 930170007957 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 930170007958 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170007959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170007960 S-adenosylmethionine binding site [chemical binding]; other site 930170007961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170007962 putative substrate translocation pore; other site 930170007963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170007964 aspartate aminotransferase; Provisional; Region: PRK07681 930170007965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170007966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170007967 homodimer interface [polypeptide binding]; other site 930170007968 catalytic residue [active] 930170007969 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 930170007970 pantothenate kinase; Provisional; Region: PRK13317 930170007971 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 930170007972 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 930170007973 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 930170007974 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 930170007975 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170007976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170007977 Walker A/P-loop; other site 930170007978 ATP binding site [chemical binding]; other site 930170007979 Q-loop/lid; other site 930170007980 ABC transporter signature motif; other site 930170007981 Walker B; other site 930170007982 D-loop; other site 930170007983 H-loop/switch region; other site 930170007984 Predicted transcriptional regulators [Transcription]; Region: COG1725 930170007985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170007986 DNA-binding site [nucleotide binding]; DNA binding site 930170007987 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 930170007988 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 930170007989 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 930170007990 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 930170007991 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 930170007992 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 930170007993 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930170007994 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930170007995 HNH endonuclease; Region: HNH_5; pfam14279 930170007996 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 930170007997 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 930170007998 active site 930170007999 dimer interface [polypeptide binding]; other site 930170008000 non-prolyl cis peptide bond; other site 930170008001 insertion regions; other site 930170008002 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930170008003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930170008004 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 930170008005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170008006 membrane-bound complex binding site; other site 930170008007 hinge residues; other site 930170008008 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930170008009 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930170008010 Walker A/P-loop; other site 930170008011 ATP binding site [chemical binding]; other site 930170008012 Q-loop/lid; other site 930170008013 ABC transporter signature motif; other site 930170008014 Walker B; other site 930170008015 D-loop; other site 930170008016 H-loop/switch region; other site 930170008017 Protein of unknown function (DUF402); Region: DUF402; pfam04167 930170008018 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 930170008019 nudix motif; other site 930170008020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930170008021 binding surface 930170008022 TPR motif; other site 930170008023 hypothetical protein; Provisional; Region: PRK09620 930170008024 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 930170008025 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 930170008026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930170008027 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170008028 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 930170008029 DinB superfamily; Region: DinB_2; pfam12867 930170008030 Protein of unknown function (DUF664); Region: DUF664; pfam04978 930170008031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 930170008032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008033 Coenzyme A binding pocket [chemical binding]; other site 930170008034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170008035 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170008036 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 930170008037 active site 930170008038 NTP binding site [chemical binding]; other site 930170008039 metal binding triad [ion binding]; metal-binding site 930170008040 antibiotic binding site [chemical binding]; other site 930170008041 A new structural DNA glycosylase; Region: AlkD_like; cd06561 930170008042 active site 930170008043 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 930170008044 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 930170008045 NodB motif; other site 930170008046 active site 930170008047 catalytic site [active] 930170008048 Zn binding site [ion binding]; other site 930170008049 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 930170008050 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 930170008051 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930170008052 Sulfatase; Region: Sulfatase; pfam00884 930170008053 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 930170008054 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170008055 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170008056 ABC transporter; Region: ABC_tran_2; pfam12848 930170008057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170008058 hypothetical protein; Provisional; Region: PRK06761 930170008059 MMPL family; Region: MMPL; pfam03176 930170008060 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 930170008061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170008062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170008063 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 930170008064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008065 Coenzyme A binding pocket [chemical binding]; other site 930170008066 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 930170008067 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 930170008068 hinge; other site 930170008069 active site 930170008070 prephenate dehydrogenase; Validated; Region: PRK06545 930170008071 prephenate dehydrogenase; Validated; Region: PRK08507 930170008072 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 930170008073 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 930170008074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170008075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170008076 homodimer interface [polypeptide binding]; other site 930170008077 catalytic residue [active] 930170008078 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 930170008079 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 930170008080 Tetramer interface [polypeptide binding]; other site 930170008081 active site 930170008082 FMN-binding site [chemical binding]; other site 930170008083 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 930170008084 Chorismate mutase type II; Region: CM_2; cl00693 930170008085 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 930170008086 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 930170008087 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 930170008088 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 930170008089 Isochorismatase family; Region: Isochorismatase; pfam00857 930170008090 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 930170008091 catalytic triad [active] 930170008092 conserved cis-peptide bond; other site 930170008093 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 930170008094 Isochorismatase family; Region: Isochorismatase; pfam00857 930170008095 catalytic triad [active] 930170008096 conserved cis-peptide bond; other site 930170008097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170008099 Coenzyme A binding pocket [chemical binding]; other site 930170008100 YfzA-like protein; Region: YfzA; pfam14118 930170008101 hypothetical protein; Provisional; Region: PRK06762 930170008102 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170008103 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170008104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930170008105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170008107 putative substrate translocation pore; other site 930170008108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170008110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170008111 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 930170008112 malate:quinone oxidoreductase; Validated; Region: PRK05257 930170008113 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 930170008114 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 930170008115 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 930170008116 ligand binding site [chemical binding]; other site 930170008117 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930170008118 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170008119 TM-ABC transporter signature motif; other site 930170008120 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170008121 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930170008122 TM-ABC transporter signature motif; other site 930170008123 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930170008124 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930170008125 Walker A/P-loop; other site 930170008126 ATP binding site [chemical binding]; other site 930170008127 Q-loop/lid; other site 930170008128 ABC transporter signature motif; other site 930170008129 Walker B; other site 930170008130 D-loop; other site 930170008131 H-loop/switch region; other site 930170008132 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930170008133 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930170008134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 930170008135 DNA binding residues [nucleotide binding] 930170008136 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930170008137 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 930170008138 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 930170008139 putative N- and C-terminal domain interface [polypeptide binding]; other site 930170008140 putative active site [active] 930170008141 putative MgATP binding site [chemical binding]; other site 930170008142 catalytic site [active] 930170008143 metal binding site [ion binding]; metal-binding site 930170008144 putative carbohydrate binding site [chemical binding]; other site 930170008145 Cupin domain; Region: Cupin_2; pfam07883 930170008146 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 930170008147 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 930170008148 putative active site; other site 930170008149 catalytic residue [active] 930170008150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 930170008151 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 930170008152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008153 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170008154 putative substrate translocation pore; other site 930170008155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170008156 putative DNA binding site [nucleotide binding]; other site 930170008157 putative Zn2+ binding site [ion binding]; other site 930170008158 DinB superfamily; Region: DinB_2; pfam12867 930170008159 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170008160 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170008161 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170008162 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 930170008163 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 930170008164 putative catalytic cysteine [active] 930170008165 gamma-glutamyl kinase; Provisional; Region: PRK05429 930170008166 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 930170008167 nucleotide binding site [chemical binding]; other site 930170008168 homotetrameric interface [polypeptide binding]; other site 930170008169 putative phosphate binding site [ion binding]; other site 930170008170 putative allosteric binding site; other site 930170008171 PUA domain; Region: PUA; pfam01472 930170008172 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 930170008173 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 930170008174 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 930170008175 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 930170008176 putative metal binding site [ion binding]; other site 930170008177 putative dimer interface [polypeptide binding]; other site 930170008178 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930170008179 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930170008180 Bacterial transcriptional regulator; Region: IclR; pfam01614 930170008181 S-methylmethionine transporter; Provisional; Region: PRK11387 930170008182 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 930170008183 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 930170008184 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 930170008185 putative di-iron ligands [ion binding]; other site 930170008186 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930170008187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 930170008188 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 930170008189 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 930170008190 dimer interface [polypeptide binding]; other site 930170008191 Alkaline phosphatase homologues; Region: alkPPc; smart00098 930170008192 active site 930170008193 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 930170008194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170008195 salt bridge; other site 930170008196 non-specific DNA binding site [nucleotide binding]; other site 930170008197 sequence-specific DNA binding site [nucleotide binding]; other site 930170008198 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 930170008199 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 930170008200 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 930170008201 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930170008202 LytTr DNA-binding domain; Region: LytTR; pfam04397 930170008203 uridine kinase; Provisional; Region: PRK07667 930170008204 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170008205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170008207 Coenzyme A binding pocket [chemical binding]; other site 930170008208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170008209 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930170008210 active site 930170008211 metal binding site [ion binding]; metal-binding site 930170008212 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 930170008213 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170008214 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930170008215 MoxR-like ATPases [General function prediction only]; Region: COG0714 930170008216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170008217 Walker A motif; other site 930170008218 ATP binding site [chemical binding]; other site 930170008219 Walker B motif; other site 930170008220 arginine finger; other site 930170008221 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930170008222 Protein of unknown function DUF58; Region: DUF58; pfam01882 930170008223 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 930170008224 proline/glycine betaine transporter; Provisional; Region: PRK10642 930170008225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008226 putative substrate translocation pore; other site 930170008227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170008228 active site 930170008229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930170008230 active site 930170008231 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 930170008232 Ligand binding site; other site 930170008233 Putative Catalytic site; other site 930170008234 DXD motif; other site 930170008235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170008236 active site 930170008237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170008238 active site 930170008239 acetylornithine aminotransferase; Provisional; Region: PRK02627 930170008240 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170008241 inhibitor-cofactor binding pocket; inhibition site 930170008242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170008243 catalytic residue [active] 930170008244 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 930170008245 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 930170008246 tetramer interface [polypeptide binding]; other site 930170008247 heme binding pocket [chemical binding]; other site 930170008248 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 930170008249 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930170008250 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 930170008251 active site 930170008252 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 930170008253 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170008254 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170008255 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 930170008256 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930170008257 Protein of unknown function DUF58; Region: DUF58; pfam01882 930170008258 MoxR-like ATPases [General function prediction only]; Region: COG0714 930170008259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170008260 Walker A motif; other site 930170008261 ATP binding site [chemical binding]; other site 930170008262 Walker B motif; other site 930170008263 arginine finger; other site 930170008264 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930170008265 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 930170008266 dimer interface [polypeptide binding]; other site 930170008267 FMN binding site [chemical binding]; other site 930170008268 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170008269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170008270 putative DNA binding site [nucleotide binding]; other site 930170008271 putative Zn2+ binding site [ion binding]; other site 930170008272 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 930170008273 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 930170008274 G1 box; other site 930170008275 putative GEF interaction site [polypeptide binding]; other site 930170008276 GTP/Mg2+ binding site [chemical binding]; other site 930170008277 Switch I region; other site 930170008278 G2 box; other site 930170008279 G3 box; other site 930170008280 Switch II region; other site 930170008281 G4 box; other site 930170008282 G5 box; other site 930170008283 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 930170008284 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 930170008285 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 930170008286 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 930170008287 nudix motif; other site 930170008288 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 930170008289 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 930170008290 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930170008291 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 930170008292 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 930170008293 putative NAD(P) binding site [chemical binding]; other site 930170008294 active site 930170008295 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170008296 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170008297 Walker A/P-loop; other site 930170008298 ATP binding site [chemical binding]; other site 930170008299 Q-loop/lid; other site 930170008300 ABC transporter signature motif; other site 930170008301 Walker B; other site 930170008302 D-loop; other site 930170008303 H-loop/switch region; other site 930170008304 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930170008305 FtsX-like permease family; Region: FtsX; pfam02687 930170008306 FtsX-like permease family; Region: FtsX; pfam02687 930170008307 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170008308 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170008309 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170008310 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170008311 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170008312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170008313 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930170008314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170008315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008316 Coenzyme A binding pocket [chemical binding]; other site 930170008317 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 930170008318 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 930170008319 nudix motif; other site 930170008320 EamA-like transporter family; Region: EamA; pfam00892 930170008321 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170008322 EamA-like transporter family; Region: EamA; pfam00892 930170008323 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170008324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170008325 DNA-binding site [nucleotide binding]; DNA binding site 930170008326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170008327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170008328 homodimer interface [polypeptide binding]; other site 930170008329 catalytic residue [active] 930170008330 hypothetical protein; Validated; Region: PRK00124 930170008331 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 930170008332 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 930170008333 uridine kinase; Validated; Region: PRK06696 930170008334 active site 930170008335 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 930170008336 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170008337 active site 930170008338 metal binding site [ion binding]; metal-binding site 930170008339 Phosphotransferase enzyme family; Region: APH; pfam01636 930170008340 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170008341 active site 930170008342 substrate binding site [chemical binding]; other site 930170008343 ATP binding site [chemical binding]; other site 930170008344 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 930170008345 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170008346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170008347 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170008348 lysine transporter; Provisional; Region: PRK10836 930170008349 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 930170008350 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170008351 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 930170008352 DNA binding residues [nucleotide binding] 930170008353 dimer interface [polypeptide binding]; other site 930170008354 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 930170008355 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 930170008356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170008357 S-adenosylmethionine binding site [chemical binding]; other site 930170008358 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 930170008359 FIC domain binding interface [polypeptide binding]; other site 930170008360 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 930170008361 putative active site [active] 930170008362 nucleotide binding site [chemical binding]; other site 930170008363 nudix motif; other site 930170008364 putative metal binding site [ion binding]; other site 930170008365 Cephalosporin hydroxylase; Region: CmcI; pfam04989 930170008366 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930170008367 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170008368 Catalytic site [active] 930170008369 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170008370 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170008371 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170008372 NAD-dependent deacetylase; Provisional; Region: PRK00481 930170008373 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 930170008374 NAD+ binding site [chemical binding]; other site 930170008375 substrate binding site [chemical binding]; other site 930170008376 Zn binding site [ion binding]; other site 930170008377 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 930170008378 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 930170008379 putative substrate binding pocket [chemical binding]; other site 930170008380 AC domain interface; other site 930170008381 catalytic triad [active] 930170008382 AB domain interface; other site 930170008383 interchain disulfide; other site 930170008384 Predicted membrane protein [Function unknown]; Region: COG3817 930170008385 Protein of unknown function (DUF979); Region: DUF979; pfam06166 930170008386 Protein of unknown function (DUF969); Region: DUF969; pfam06149 930170008387 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 930170008388 putative active site [active] 930170008389 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 930170008390 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 930170008391 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 930170008392 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930170008393 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930170008394 Bacterial transcriptional regulator; Region: IclR; pfam01614 930170008395 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930170008396 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170008397 Catalytic site [active] 930170008398 CutC family; Region: CutC; cl01218 930170008399 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 930170008400 stage II sporulation protein P; Region: spore_II_P; TIGR02867 930170008401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170008402 dimerization interface [polypeptide binding]; other site 930170008403 putative DNA binding site [nucleotide binding]; other site 930170008404 putative Zn2+ binding site [ion binding]; other site 930170008405 DinB superfamily; Region: DinB_2; pfam12867 930170008406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930170008407 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930170008408 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 930170008409 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930170008410 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930170008411 putative active site [active] 930170008412 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170008413 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170008414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 930170008415 Nucleoside recognition; Region: Gate; pfam07670 930170008416 S-layer homology domain; Region: SLH; pfam00395 930170008417 S-layer homology domain; Region: SLH; pfam00395 930170008418 S-layer homology domain; Region: SLH; pfam00395 930170008419 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 930170008420 putative active site [active] 930170008421 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170008422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008423 Coenzyme A binding pocket [chemical binding]; other site 930170008424 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 930170008425 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 930170008426 Ferritin-like domain; Region: Ferritin; pfam00210 930170008427 dinuclear metal binding motif [ion binding]; other site 930170008428 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930170008429 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930170008430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170008431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170008432 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 930170008433 phosphoenolpyruvate synthase; Validated; Region: PRK06241 930170008434 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930170008435 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930170008436 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 930170008437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170008438 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 930170008439 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 930170008440 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170008441 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 930170008442 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930170008443 NAD binding site [chemical binding]; other site 930170008444 catalytic Zn binding site [ion binding]; other site 930170008445 structural Zn binding site [ion binding]; other site 930170008446 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 930170008447 dimanganese center [ion binding]; other site 930170008448 aspartate ammonia-lyase; Provisional; Region: PRK14515 930170008449 Aspartase; Region: Aspartase; cd01357 930170008450 active sites [active] 930170008451 tetramer interface [polypeptide binding]; other site 930170008452 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 930170008453 active site 930170008454 homodimer interface [polypeptide binding]; other site 930170008455 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170008456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170008457 non-specific DNA binding site [nucleotide binding]; other site 930170008458 salt bridge; other site 930170008459 sequence-specific DNA binding site [nucleotide binding]; other site 930170008460 Integrase core domain; Region: rve_3; cl15866 930170008461 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170008462 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170008463 Spore germination protein; Region: Spore_permease; cl17796 930170008464 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170008465 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930170008466 PAS domain S-box; Region: sensory_box; TIGR00229 930170008467 PAS domain S-box; Region: sensory_box; TIGR00229 930170008468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170008469 putative active site [active] 930170008470 heme pocket [chemical binding]; other site 930170008471 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930170008472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170008473 putative active site [active] 930170008474 heme pocket [chemical binding]; other site 930170008475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170008476 dimer interface [polypeptide binding]; other site 930170008477 phosphorylation site [posttranslational modification] 930170008478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170008479 ATP binding site [chemical binding]; other site 930170008480 Mg2+ binding site [ion binding]; other site 930170008481 G-X-G motif; other site 930170008482 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170008483 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170008484 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170008485 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 930170008486 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 930170008487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170008488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170008489 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170008490 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930170008491 GIY-YIG motif/motif A; other site 930170008492 active site 930170008493 catalytic site [active] 930170008494 putative DNA binding site [nucleotide binding]; other site 930170008495 metal binding site [ion binding]; metal-binding site 930170008496 amino acid transporter; Region: 2A0306; TIGR00909 930170008497 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930170008498 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 930170008499 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 930170008500 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170008501 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170008502 Spore germination protein; Region: Spore_permease; pfam03845 930170008503 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170008504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170008505 Response regulator receiver domain; Region: Response_reg; pfam00072 930170008506 active site 930170008507 phosphorylation site [posttranslational modification] 930170008508 intermolecular recognition site; other site 930170008509 dimerization interface [polypeptide binding]; other site 930170008510 YcbB domain; Region: YcbB; pfam08664 930170008511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170008512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170008513 ATP binding site [chemical binding]; other site 930170008514 Mg2+ binding site [ion binding]; other site 930170008515 G-X-G motif; other site 930170008516 glutaminase; Reviewed; Region: PRK12357 930170008517 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 930170008518 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170008519 amino acid carrier protein; Region: agcS; TIGR00835 930170008520 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 930170008521 transmembrane helices; other site 930170008522 hypothetical protein; Provisional; Region: PRK06760; cl11698 930170008523 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 930170008524 Cl binding site [ion binding]; other site 930170008525 oligomer interface [polypeptide binding]; other site 930170008526 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 930170008527 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 930170008528 Mg binding site [ion binding]; other site 930170008529 nucleotide binding site [chemical binding]; other site 930170008530 putative protofilament interface [polypeptide binding]; other site 930170008531 Heat induced stress protein YflT; Region: YflT; pfam11181 930170008532 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 930170008533 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930170008534 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 930170008535 putative NAD(P) binding site [chemical binding]; other site 930170008536 catalytic Zn binding site [ion binding]; other site 930170008537 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 930170008538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170008539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 930170008540 Cytochrome P450; Region: p450; cl12078 930170008541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170008542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170008543 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930170008544 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930170008545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930170008546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930170008547 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930170008548 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930170008549 TspO/MBR family; Region: TspO_MBR; pfam03073 930170008550 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 930170008551 DNA photolyase; Region: DNA_photolyase; pfam00875 930170008552 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170008553 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930170008554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170008556 putative substrate translocation pore; other site 930170008557 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 930170008558 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930170008559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930170008560 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930170008561 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 930170008562 zinc binding site [ion binding]; other site 930170008563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 930170008564 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 930170008565 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 930170008566 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930170008567 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 930170008568 Protein of unknown function DUF58; Region: DUF58; pfam01882 930170008569 MoxR-like ATPases [General function prediction only]; Region: COG0714 930170008570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170008571 Walker A motif; other site 930170008572 ATP binding site [chemical binding]; other site 930170008573 Walker B motif; other site 930170008574 arginine finger; other site 930170008575 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 930170008576 UbiA prenyltransferase family; Region: UbiA; pfam01040 930170008577 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 930170008578 B12 binding site [chemical binding]; other site 930170008579 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 930170008580 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 930170008581 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 930170008582 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 930170008583 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 930170008584 short chain dehydrogenase; Validated; Region: PRK08324 930170008585 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 930170008586 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 930170008587 putative NAD(P) binding site [chemical binding]; other site 930170008588 active site 930170008589 L-fucose isomerase; Provisional; Region: fucI; PRK10991 930170008590 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 930170008591 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930170008592 trimer interface [polypeptide binding]; other site 930170008593 substrate binding site [chemical binding]; other site 930170008594 Mn binding site [ion binding]; other site 930170008595 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 930170008596 N- and C-terminal domain interface [polypeptide binding]; other site 930170008597 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 930170008598 active site 930170008599 putative catalytic site [active] 930170008600 metal binding site [ion binding]; metal-binding site 930170008601 ATP binding site [chemical binding]; other site 930170008602 carbohydrate binding site [chemical binding]; other site 930170008603 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 930170008604 intersubunit interface [polypeptide binding]; other site 930170008605 active site 930170008606 Zn2+ binding site [ion binding]; other site 930170008607 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 930170008608 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930170008609 putative ligand binding site [chemical binding]; other site 930170008610 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170008611 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930170008612 TM-ABC transporter signature motif; other site 930170008613 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930170008614 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930170008615 Walker A/P-loop; other site 930170008616 ATP binding site [chemical binding]; other site 930170008617 Q-loop/lid; other site 930170008618 ABC transporter signature motif; other site 930170008619 Walker B; other site 930170008620 D-loop; other site 930170008621 H-loop/switch region; other site 930170008622 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930170008623 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 930170008624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170008625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170008626 DNA binding site [nucleotide binding] 930170008627 domain linker motif; other site 930170008628 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930170008629 dimerization interface [polypeptide binding]; other site 930170008630 ligand binding site [chemical binding]; other site 930170008631 Phosphotransferase enzyme family; Region: APH; pfam01636 930170008632 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170008633 active site 930170008634 ATP binding site [chemical binding]; other site 930170008635 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 930170008636 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930170008637 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930170008638 active site 930170008639 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 930170008640 arsenical-resistance protein; Region: acr3; TIGR00832 930170008641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170008642 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 930170008643 putative metal binding site [ion binding]; other site 930170008644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170008645 dimerization interface [polypeptide binding]; other site 930170008646 putative DNA binding site [nucleotide binding]; other site 930170008647 putative Zn2+ binding site [ion binding]; other site 930170008648 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 930170008649 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 930170008650 TPR repeat; Region: TPR_11; pfam13414 930170008651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170008652 binding surface 930170008653 TPR motif; other site 930170008654 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170008655 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 930170008656 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 930170008657 nucleotide binding site [chemical binding]; other site 930170008658 putative NEF/HSP70 interaction site [polypeptide binding]; other site 930170008659 SBD interface [polypeptide binding]; other site 930170008660 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 930170008661 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930170008662 metal binding site [ion binding]; metal-binding site 930170008663 AAA domain; Region: AAA_11; pfam13086 930170008664 Part of AAA domain; Region: AAA_19; pfam13245 930170008665 Erp protein C-terminus; Region: Erp_C; pfam06780 930170008666 AAA domain; Region: AAA_30; pfam13604 930170008667 AAA domain; Region: AAA_12; pfam13087 930170008668 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 930170008669 putative active site [active] 930170008670 catalytic site [active] 930170008671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170008672 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930170008673 active site 930170008674 metal binding site [ion binding]; metal-binding site 930170008675 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 930170008676 hypothetical protein; Provisional; Region: PRK06770 930170008677 putative monooxygenase; Provisional; Region: PRK11118 930170008678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170008679 S-adenosylmethionine binding site [chemical binding]; other site 930170008680 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170008681 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170008682 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 930170008683 Cytochrome P450; Region: p450; pfam00067 930170008684 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 930170008685 Flavodoxin; Region: Flavodoxin_1; pfam00258 930170008686 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 930170008687 FAD binding pocket [chemical binding]; other site 930170008688 FAD binding motif [chemical binding]; other site 930170008689 catalytic residues [active] 930170008690 NAD binding pocket [chemical binding]; other site 930170008691 phosphate binding motif [ion binding]; other site 930170008692 beta-alpha-beta structure motif; other site 930170008693 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930170008694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008695 putative substrate translocation pore; other site 930170008696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008697 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 930170008698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 930170008699 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 930170008700 Probable transposase; Region: OrfB_IS605; pfam01385 930170008701 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 930170008702 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 930170008703 D-cysteine desulfhydrase; Validated; Region: PRK03910 930170008704 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 930170008705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170008706 catalytic residue [active] 930170008707 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170008708 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 930170008709 active site 930170008710 metal binding site [ion binding]; metal-binding site 930170008711 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 930170008712 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 930170008713 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 930170008714 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930170008715 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930170008716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170008717 NAD(P) binding site [chemical binding]; other site 930170008718 active site 930170008719 hypothetical protein; Provisional; Region: PRK06849 930170008720 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 930170008721 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 930170008722 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930170008723 dimer interface [polypeptide binding]; other site 930170008724 active site 930170008725 CoA binding pocket [chemical binding]; other site 930170008726 CAAX protease self-immunity; Region: Abi; pfam02517 930170008727 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 930170008728 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170008729 DNA binding residues [nucleotide binding] 930170008730 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 930170008731 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 930170008732 AAA domain; Region: AAA_33; pfam13671 930170008733 AAA domain; Region: AAA_17; pfam13207 930170008734 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 930170008735 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930170008736 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170008737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170008738 Walker A/P-loop; other site 930170008739 ATP binding site [chemical binding]; other site 930170008740 Q-loop/lid; other site 930170008741 ABC transporter signature motif; other site 930170008742 Walker B; other site 930170008743 D-loop; other site 930170008744 H-loop/switch region; other site 930170008745 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930170008746 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170008747 FtsX-like permease family; Region: FtsX; pfam02687 930170008748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170008749 dimerization interface [polypeptide binding]; other site 930170008750 putative DNA binding site [nucleotide binding]; other site 930170008751 Predicted transcriptional regulator [Transcription]; Region: COG2345 930170008752 putative Zn2+ binding site [ion binding]; other site 930170008753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008754 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170008755 putative substrate translocation pore; other site 930170008756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170008757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170008758 dimerization interface [polypeptide binding]; other site 930170008759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170008760 dimer interface [polypeptide binding]; other site 930170008761 phosphorylation site [posttranslational modification] 930170008762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170008763 ATP binding site [chemical binding]; other site 930170008764 Mg2+ binding site [ion binding]; other site 930170008765 G-X-G motif; other site 930170008766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170008767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170008768 active site 930170008769 phosphorylation site [posttranslational modification] 930170008770 intermolecular recognition site; other site 930170008771 dimerization interface [polypeptide binding]; other site 930170008772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170008773 DNA binding site [nucleotide binding] 930170008774 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170008775 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170008776 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170008777 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 930170008778 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 930170008779 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 930170008780 catalytic residues [active] 930170008781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 930170008782 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 930170008783 Probable transposase; Region: OrfB_IS605; pfam01385 930170008784 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170008785 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930170008786 putative dimer interface [polypeptide binding]; other site 930170008787 catalytic triad [active] 930170008788 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 930170008789 Uncharacterized conserved protein [Function unknown]; Region: COG4198 930170008790 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 930170008791 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 930170008792 glyoxylate reductase; Reviewed; Region: PRK13243 930170008793 putative ligand binding site [chemical binding]; other site 930170008794 putative NAD binding site [chemical binding]; other site 930170008795 putative catalytic site [active] 930170008796 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 930170008797 L-serine binding site [chemical binding]; other site 930170008798 ACT domain interface; other site 930170008799 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 930170008800 homodimer interface [polypeptide binding]; other site 930170008801 substrate-cofactor binding pocket; other site 930170008802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170008803 catalytic residue [active] 930170008804 Uncharacterized conserved protein [Function unknown]; Region: COG2155 930170008805 Cupin domain; Region: Cupin_2; cl17218 930170008806 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 930170008807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170008808 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 930170008809 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 930170008810 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 930170008811 active site 930170008812 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 930170008813 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170008814 amidase catalytic site [active] 930170008815 Zn binding residues [ion binding]; other site 930170008816 substrate binding site [chemical binding]; other site 930170008817 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170008818 S-layer homology domain; Region: SLH; pfam00395 930170008819 S-layer homology domain; Region: SLH; pfam00395 930170008820 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930170008821 A new structural DNA glycosylase; Region: AlkD_like; cd06561 930170008822 active site 930170008823 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 930170008824 S-layer homology domain; Region: SLH; pfam00395 930170008825 S-layer homology domain; Region: SLH; pfam00395 930170008826 S-layer homology domain; Region: SLH; pfam00395 930170008827 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 930170008828 putative metal binding site [ion binding]; other site 930170008829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170008830 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 930170008831 NETI protein; Region: NETI; pfam14044 930170008832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170008834 putative substrate translocation pore; other site 930170008835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170008836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930170008837 TAP-like protein; Region: Abhydrolase_4; pfam08386 930170008838 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170008839 MarR family; Region: MarR_2; pfam12802 930170008840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170008841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008842 putative substrate translocation pore; other site 930170008843 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170008844 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170008845 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 930170008846 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 930170008847 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 930170008848 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170008849 SWIM zinc finger; Region: SWIM; pfam04434 930170008850 YwiC-like protein; Region: YwiC; pfam14256 930170008851 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 930170008852 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930170008853 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930170008854 Walker A/P-loop; other site 930170008855 ATP binding site [chemical binding]; other site 930170008856 Q-loop/lid; other site 930170008857 ABC transporter signature motif; other site 930170008858 Walker B; other site 930170008859 D-loop; other site 930170008860 H-loop/switch region; other site 930170008861 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930170008862 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 930170008863 Walker A/P-loop; other site 930170008864 ATP binding site [chemical binding]; other site 930170008865 Q-loop/lid; other site 930170008866 ABC transporter signature motif; other site 930170008867 Walker B; other site 930170008868 D-loop; other site 930170008869 H-loop/switch region; other site 930170008870 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930170008871 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 930170008872 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 930170008873 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 930170008874 Predicted membrane protein [Function unknown]; Region: COG1288 930170008875 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 930170008876 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 930170008877 DNA binding residues [nucleotide binding] 930170008878 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170008879 dimer interface [polypeptide binding]; other site 930170008880 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 930170008881 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930170008882 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 930170008883 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170008884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170008885 non-specific DNA binding site [nucleotide binding]; other site 930170008886 salt bridge; other site 930170008887 sequence-specific DNA binding site [nucleotide binding]; other site 930170008888 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170008889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008890 Coenzyme A binding pocket [chemical binding]; other site 930170008891 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 930170008892 putative deacylase active site [active] 930170008893 histidyl-tRNA synthetase; Provisional; Region: PRK12420 930170008894 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930170008895 dimer interface [polypeptide binding]; other site 930170008896 motif 1; other site 930170008897 active site 930170008898 motif 2; other site 930170008899 motif 3; other site 930170008900 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 930170008901 anticodon binding site; other site 930170008902 Predicted transcriptional regulators [Transcription]; Region: COG1733 930170008903 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930170008904 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 930170008905 dimer interface [polypeptide binding]; other site 930170008906 FMN binding site [chemical binding]; other site 930170008907 pyruvate kinase; Validated; Region: PRK06739 930170008908 active site 930170008909 domain interfaces; other site 930170008910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 930170008911 classical (c) SDRs; Region: SDR_c; cd05233 930170008912 NAD(P) binding site [chemical binding]; other site 930170008913 active site 930170008914 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930170008915 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170008916 Walker A/P-loop; other site 930170008917 ATP binding site [chemical binding]; other site 930170008918 Q-loop/lid; other site 930170008919 ABC transporter signature motif; other site 930170008920 Walker B; other site 930170008921 D-loop; other site 930170008922 H-loop/switch region; other site 930170008923 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 930170008924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170008925 non-specific DNA binding site [nucleotide binding]; other site 930170008926 salt bridge; other site 930170008927 sequence-specific DNA binding site [nucleotide binding]; other site 930170008928 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 930170008929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170008930 motif II; other site 930170008931 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930170008932 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 930170008933 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 930170008934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170008935 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 930170008936 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 930170008937 nudix motif; other site 930170008938 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 930170008939 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170008940 putative metal binding site [ion binding]; other site 930170008941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930170008942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930170008943 maltose O-acetyltransferase; Provisional; Region: PRK10092 930170008944 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 930170008945 active site 930170008946 substrate binding site [chemical binding]; other site 930170008947 trimer interface [polypeptide binding]; other site 930170008948 CoA binding site [chemical binding]; other site 930170008949 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 930170008950 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 930170008951 active site 930170008952 HIGH motif; other site 930170008953 dimer interface [polypeptide binding]; other site 930170008954 KMSKS motif; other site 930170008955 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 930170008956 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930170008957 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930170008958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170008959 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170008960 Coenzyme A binding pocket [chemical binding]; other site 930170008961 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 930170008962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170008963 S-adenosylmethionine binding site [chemical binding]; other site 930170008964 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 930170008965 CGNR zinc finger; Region: zf-CGNR; pfam11706 930170008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170008967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170008968 putative substrate translocation pore; other site 930170008969 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 930170008970 hypothetical protein; Provisional; Region: PRK04164 930170008971 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170008972 ATP synthase I chain; Region: ATP_synt_I; pfam03899 930170008973 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930170008974 Domain of unknown function DUF21; Region: DUF21; pfam01595 930170008975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930170008976 Transporter associated domain; Region: CorC_HlyC; smart01091 930170008977 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 930170008978 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170008979 DNA binding residues [nucleotide binding] 930170008980 putative dimer interface [polypeptide binding]; other site 930170008981 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 930170008982 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 930170008983 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 930170008984 substrate binding site; other site 930170008985 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 930170008986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170008987 NAD(P) binding site [chemical binding]; other site 930170008988 active site 930170008989 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 930170008990 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170008991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170008992 S-adenosylmethionine binding site [chemical binding]; other site 930170008993 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 930170008994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170008995 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 930170008996 NAD(P) binding site [chemical binding]; other site 930170008997 active site 930170008998 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 930170008999 Variant SH3 domain; Region: SH3_2; pfam07653 930170009000 EamA-like transporter family; Region: EamA; pfam00892 930170009001 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170009002 EamA-like transporter family; Region: EamA; pfam00892 930170009003 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 930170009004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 930170009005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 930170009006 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 930170009007 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 930170009008 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 930170009009 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 930170009010 N- and C-terminal domain interface [polypeptide binding]; other site 930170009011 active site 930170009012 catalytic site [active] 930170009013 metal binding site [ion binding]; metal-binding site 930170009014 carbohydrate binding site [chemical binding]; other site 930170009015 ATP binding site [chemical binding]; other site 930170009016 GntP family permease; Region: GntP_permease; pfam02447 930170009017 fructuronate transporter; Provisional; Region: PRK10034; cl15264 930170009018 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 930170009019 active site 930170009020 intersubunit interactions; other site 930170009021 catalytic residue [active] 930170009022 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 930170009023 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930170009024 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930170009025 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930170009026 TPP-binding site [chemical binding]; other site 930170009027 dimer interface [polypeptide binding]; other site 930170009028 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930170009029 PYR/PP interface [polypeptide binding]; other site 930170009030 dimer interface [polypeptide binding]; other site 930170009031 TPP binding site [chemical binding]; other site 930170009032 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170009033 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 930170009034 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 930170009035 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 930170009036 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 930170009037 dimer interface [polypeptide binding]; other site 930170009038 FMN binding site [chemical binding]; other site 930170009039 hypothetical protein; Provisional; Region: PRK02487 930170009040 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 930170009041 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 930170009042 IDEAL domain; Region: IDEAL; pfam08858 930170009043 Transcriptional regulator; Region: Rrf2; pfam02082 930170009044 Rrf2 family protein; Region: rrf2_super; TIGR00738 930170009045 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 930170009046 ArsC family; Region: ArsC; pfam03960 930170009047 putative catalytic residues [active] 930170009048 thiol/disulfide switch; other site 930170009049 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930170009050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170009051 DNA-binding site [nucleotide binding]; DNA binding site 930170009052 UTRA domain; Region: UTRA; pfam07702 930170009053 putative oxidoreductase; Provisional; Region: PRK10206 930170009054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930170009055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930170009056 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 930170009057 putative hydrophobic ligand binding site [chemical binding]; other site 930170009058 protein interface [polypeptide binding]; other site 930170009059 gate; other site 930170009060 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 930170009061 catalytic triad [active] 930170009062 oxyanion hole [active] 930170009063 active site 930170009064 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170009065 Phosphotransferase enzyme family; Region: APH; pfam01636 930170009066 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930170009067 active site 930170009068 ATP binding site [chemical binding]; other site 930170009069 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 930170009070 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 930170009071 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 930170009072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170009073 Coenzyme A binding pocket [chemical binding]; other site 930170009074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170009075 short chain dehydrogenase; Provisional; Region: PRK12828 930170009076 NAD(P) binding site [chemical binding]; other site 930170009077 active site 930170009078 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170009079 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170009080 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 930170009081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170009082 acyl-activating enzyme (AAE) consensus motif; other site 930170009083 AMP binding site [chemical binding]; other site 930170009084 active site 930170009085 CoA binding site [chemical binding]; other site 930170009086 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 930170009087 Predicted transcriptional regulators [Transcription]; Region: COG1733 930170009088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170009089 dimerization interface [polypeptide binding]; other site 930170009090 putative DNA binding site [nucleotide binding]; other site 930170009091 putative Zn2+ binding site [ion binding]; other site 930170009092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170009093 dimerization interface [polypeptide binding]; other site 930170009094 putative DNA binding site [nucleotide binding]; other site 930170009095 putative Zn2+ binding site [ion binding]; other site 930170009096 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 930170009097 active site 930170009098 Glyco_18 domain; Region: Glyco_18; smart00636 930170009099 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 930170009100 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 930170009101 NodB motif; other site 930170009102 putative active site [active] 930170009103 putative catalytic site [active] 930170009104 putative Zn binding site [ion binding]; other site 930170009105 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930170009106 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 930170009107 DXD motif; other site 930170009108 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 930170009109 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 930170009110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170009111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930170009112 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 930170009113 active site 930170009114 CAAX protease self-immunity; Region: Abi; pfam02517 930170009115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170009116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170009117 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 930170009118 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 930170009119 Predicted transcriptional regulator [Transcription]; Region: COG2378 930170009120 HTH domain; Region: HTH_11; pfam08279 930170009121 WYL domain; Region: WYL; pfam13280 930170009122 Protein of unknown function (DUF805); Region: DUF805; pfam05656 930170009123 ABC-2 type transporter; Region: ABC2_membrane; cl17235 930170009124 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930170009125 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930170009126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170009127 Walker A/P-loop; other site 930170009128 ATP binding site [chemical binding]; other site 930170009129 Q-loop/lid; other site 930170009130 ABC transporter signature motif; other site 930170009131 Walker B; other site 930170009132 D-loop; other site 930170009133 H-loop/switch region; other site 930170009134 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 930170009135 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170009136 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170009137 hydroxylamine reductase; Provisional; Region: PRK12310 930170009138 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 930170009139 ACS interaction site; other site 930170009140 CODH interaction site; other site 930170009141 metal cluster binding site [ion binding]; other site 930170009142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170009143 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 930170009144 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 930170009145 active site 930170009146 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 930170009147 metal binding site [ion binding]; metal-binding site 930170009148 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 930170009149 hypothetical protein; Provisional; Region: PRK06771 930170009150 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170009151 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170009152 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 930170009153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 930170009154 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 930170009155 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170009156 active site 930170009157 metal binding site [ion binding]; metal-binding site 930170009158 homotetramer interface [polypeptide binding]; other site 930170009159 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 930170009160 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930170009161 ligand binding site [chemical binding]; other site 930170009162 flexible hinge region; other site 930170009163 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930170009164 Protein of unknown function, DUF606; Region: DUF606; pfam04657 930170009165 Protein of unknown function, DUF606; Region: DUF606; pfam04657 930170009166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170009167 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 930170009168 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930170009169 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 930170009170 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 930170009171 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 930170009172 putative NAD(P) binding site [chemical binding]; other site 930170009173 dimer interface [polypeptide binding]; other site 930170009174 putative transport protein YifK; Provisional; Region: PRK10746 930170009175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170009176 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 930170009177 putative substrate translocation pore; other site 930170009178 Haemolysin XhlA; Region: XhlA; pfam10779 930170009179 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 930170009180 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 930170009181 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 930170009182 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 930170009183 transmembrane helices; other site 930170009184 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170009185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170009186 Coenzyme A binding pocket [chemical binding]; other site 930170009187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170009188 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170009189 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 930170009190 putative ligand binding residues [chemical binding]; other site 930170009191 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930170009192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170009193 ABC-ATPase subunit interface; other site 930170009194 dimer interface [polypeptide binding]; other site 930170009195 putative PBP binding regions; other site 930170009196 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170009197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170009198 ABC-ATPase subunit interface; other site 930170009199 dimer interface [polypeptide binding]; other site 930170009200 putative PBP binding regions; other site 930170009201 Protein of unknown function (DUF817); Region: DUF817; pfam05675 930170009202 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 930170009203 DinB superfamily; Region: DinB_2; pfam12867 930170009204 DinB family; Region: DinB; cl17821 930170009205 CAAX protease self-immunity; Region: Abi; pfam02517 930170009206 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 930170009207 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 930170009208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170009209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170009210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170009211 dimerization interface [polypeptide binding]; other site 930170009212 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930170009213 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 930170009214 NADP binding site [chemical binding]; other site 930170009215 dimer interface [polypeptide binding]; other site 930170009216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170009217 catalytic core [active] 930170009218 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170009219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170009220 Coenzyme A binding pocket [chemical binding]; other site 930170009221 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 930170009222 MutS domain III; Region: MutS_III; pfam05192 930170009223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170009224 Walker A/P-loop; other site 930170009225 ATP binding site [chemical binding]; other site 930170009226 Q-loop/lid; other site 930170009227 ABC transporter signature motif; other site 930170009228 Walker B; other site 930170009229 D-loop; other site 930170009230 H-loop/switch region; other site 930170009231 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 930170009232 oligoendopeptidase F; Region: pepF; TIGR00181 930170009233 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 930170009234 active site 930170009235 Zn binding site [ion binding]; other site 930170009236 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170009237 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170009238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170009239 putative substrate translocation pore; other site 930170009240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170009241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170009242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170009243 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 930170009244 putative dimerization interface [polypeptide binding]; other site 930170009245 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 930170009246 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930170009247 putative active site [active] 930170009248 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 930170009249 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930170009250 active site 930170009251 catalytic site [active] 930170009252 metal binding site [ion binding]; metal-binding site 930170009253 FAD binding domain; Region: FAD_binding_3; pfam01494 930170009254 hypothetical protein; Provisional; Region: PRK07236 930170009255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170009256 dimerization interface [polypeptide binding]; other site 930170009257 putative DNA binding site [nucleotide binding]; other site 930170009258 putative Zn2+ binding site [ion binding]; other site 930170009259 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930170009260 Uncharacterized conserved protein [Function unknown]; Region: COG0397 930170009261 hypothetical protein; Validated; Region: PRK00029 930170009262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170009263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170009264 TPR motif; other site 930170009265 binding surface 930170009266 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 930170009267 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 930170009268 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 930170009269 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 930170009270 Sodium Bile acid symporter family; Region: SBF; cl17470 930170009271 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 930170009272 FAD binding domain; Region: FAD_binding_4; pfam01565 930170009273 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 930170009274 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170009275 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170009276 PAS domain S-box; Region: sensory_box; TIGR00229 930170009277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170009278 putative active site [active] 930170009279 heme pocket [chemical binding]; other site 930170009280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170009281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170009282 metal binding site [ion binding]; metal-binding site 930170009283 active site 930170009284 I-site; other site 930170009285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170009286 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170009287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170009288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170009289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170009290 beta-channel forming cytolysin; Region: hlyII; TIGR01002 930170009291 S-layer homology domain; Region: SLH; pfam00395 930170009292 S-layer homology domain; Region: SLH; pfam00395 930170009293 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930170009294 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930170009295 active site 930170009296 metal binding site [ion binding]; metal-binding site 930170009297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170009298 dimerization interface [polypeptide binding]; other site 930170009299 putative DNA binding site [nucleotide binding]; other site 930170009300 putative Zn2+ binding site [ion binding]; other site 930170009301 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930170009302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170009303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170009304 dimer interface [polypeptide binding]; other site 930170009305 phosphorylation site [posttranslational modification] 930170009306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170009307 ATP binding site [chemical binding]; other site 930170009308 G-X-G motif; other site 930170009309 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 930170009310 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 930170009311 FOG: PKD repeat [General function prediction only]; Region: COG3291 930170009312 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 930170009313 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 930170009314 MgtC family; Region: MgtC; pfam02308 930170009315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170009316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170009317 Coenzyme A binding pocket [chemical binding]; other site 930170009318 VanW like protein; Region: VanW; pfam04294 930170009319 Sensor protein DegS; Region: DegS; pfam05384 930170009320 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 930170009321 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 930170009322 exonuclease; Provisional; Region: PRK06722 930170009323 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 930170009324 active site 930170009325 catalytic site [active] 930170009326 substrate binding site [chemical binding]; other site 930170009327 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930170009328 DNA-binding site [nucleotide binding]; DNA binding site 930170009329 RNA-binding motif; other site 930170009330 flavodoxin; Provisional; Region: PRK06703 930170009331 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 930170009332 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930170009333 nudix motif; other site 930170009334 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 930170009335 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 930170009336 trimer interface [polypeptide binding]; other site 930170009337 active site 930170009338 substrate binding site [chemical binding]; other site 930170009339 CoA binding site [chemical binding]; other site 930170009340 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009341 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009342 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009343 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009344 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009345 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009346 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009347 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009348 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009349 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009350 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009351 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009352 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009353 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009354 short chain dehydrogenase; Provisional; Region: PRK06924 930170009355 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 930170009356 NADP binding site [chemical binding]; other site 930170009357 homodimer interface [polypeptide binding]; other site 930170009358 active site 930170009359 Predicted acetyltransferase [General function prediction only]; Region: COG3393 930170009360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170009361 argininosuccinate lyase; Provisional; Region: PRK06705 930170009362 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 930170009363 active sites [active] 930170009364 tetramer interface [polypeptide binding]; other site 930170009365 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170009366 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170009367 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 930170009368 active site 930170009369 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 930170009370 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 930170009371 Na binding site [ion binding]; other site 930170009372 Protein of unknown function (DUF997); Region: DUF997; pfam06196 930170009373 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 930170009374 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930170009375 NAD(P) binding site [chemical binding]; other site 930170009376 catalytic residues [active] 930170009377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 930170009378 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 930170009379 NAD(P) binding site [chemical binding]; other site 930170009380 homotetramer interface [polypeptide binding]; other site 930170009381 homodimer interface [polypeptide binding]; other site 930170009382 active site 930170009383 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 930170009384 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 930170009385 Divergent PAP2 family; Region: DUF212; pfam02681 930170009386 Predicted permeases [General function prediction only]; Region: RarD; COG2962 930170009387 EamA-like transporter family; Region: EamA; pfam00892 930170009388 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 930170009389 antiporter inner membrane protein; Provisional; Region: PRK11670 930170009390 Domain of unknown function DUF59; Region: DUF59; pfam01883 930170009391 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 930170009392 Walker A motif; other site 930170009393 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 930170009394 MoaE interaction surface [polypeptide binding]; other site 930170009395 MoeB interaction surface [polypeptide binding]; other site 930170009396 thiocarboxylated glycine; other site 930170009397 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 930170009398 MoaE homodimer interface [polypeptide binding]; other site 930170009399 MoaD interaction [polypeptide binding]; other site 930170009400 active site residues [active] 930170009401 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930170009402 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930170009403 dimer interface [polypeptide binding]; other site 930170009404 putative functional site; other site 930170009405 putative MPT binding site; other site 930170009406 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 930170009407 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930170009408 ATP binding site [chemical binding]; other site 930170009409 substrate interface [chemical binding]; other site 930170009410 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 930170009411 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 930170009412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170009413 FeS/SAM binding site; other site 930170009414 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 930170009415 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 930170009416 Uncharacterized conserved protein [Function unknown]; Region: COG5609 930170009417 Uncharacterized conserved protein [Function unknown]; Region: COG2427 930170009418 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 930170009419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930170009420 catalytic loop [active] 930170009421 iron binding site [ion binding]; other site 930170009422 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 930170009423 4Fe-4S binding domain; Region: Fer4; pfam00037 930170009424 4Fe-4S binding domain; Region: Fer4; pfam00037 930170009425 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 930170009426 [4Fe-4S] binding site [ion binding]; other site 930170009427 molybdopterin cofactor binding site; other site 930170009428 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 930170009429 molybdopterin cofactor binding site; other site 930170009430 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170009431 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 930170009432 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170009433 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170009434 Tubulin like; Region: Tubulin_2; pfam13809 930170009435 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 930170009436 metal ion-dependent adhesion site (MIDAS); other site 930170009437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170009438 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930170009439 active site 930170009440 metal binding site [ion binding]; metal-binding site 930170009441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930170009442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170009443 S-adenosylmethionine binding site [chemical binding]; other site 930170009444 O-methyltransferase; Region: Methyltransf_2; pfam00891 930170009445 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170009446 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170009447 peptide binding site [polypeptide binding]; other site 930170009448 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170009449 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170009450 peptide binding site [polypeptide binding]; other site 930170009451 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170009452 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170009453 peptide binding site [polypeptide binding]; other site 930170009454 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 930170009455 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930170009456 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930170009457 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 930170009458 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170009459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170009460 DNA binding residues [nucleotide binding] 930170009461 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930170009462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170009463 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170009464 Walker A/P-loop; other site 930170009465 ATP binding site [chemical binding]; other site 930170009466 Q-loop/lid; other site 930170009467 ABC transporter signature motif; other site 930170009468 Walker B; other site 930170009469 D-loop; other site 930170009470 H-loop/switch region; other site 930170009471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170009472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170009473 Predicted transcriptional regulator [Transcription]; Region: COG2378 930170009474 HTH domain; Region: HTH_11; pfam08279 930170009475 WYL domain; Region: WYL; pfam13280 930170009476 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930170009477 dimer interface [polypeptide binding]; other site 930170009478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170009479 putative oxidoreductase; Provisional; Region: PRK11579 930170009480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930170009481 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930170009482 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 930170009483 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930170009484 CAP-like domain; other site 930170009485 active site 930170009486 primary dimer interface [polypeptide binding]; other site 930170009487 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170009488 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170009489 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170009490 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930170009491 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 930170009492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170009493 ATP binding site [chemical binding]; other site 930170009494 Mg2+ binding site [ion binding]; other site 930170009495 G-X-G motif; other site 930170009496 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930170009497 anchoring element; other site 930170009498 dimer interface [polypeptide binding]; other site 930170009499 ATP binding site [chemical binding]; other site 930170009500 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930170009501 active site 930170009502 putative metal-binding site [ion binding]; other site 930170009503 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930170009504 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 930170009505 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930170009506 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930170009507 protein binding site [polypeptide binding]; other site 930170009508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170009509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170009510 active site 930170009511 phosphorylation site [posttranslational modification] 930170009512 intermolecular recognition site; other site 930170009513 dimerization interface [polypeptide binding]; other site 930170009514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170009515 DNA binding site [nucleotide binding] 930170009516 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 930170009517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170009518 FeS/SAM binding site; other site 930170009519 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 930170009520 Class III ribonucleotide reductase; Region: RNR_III; cd01675 930170009521 effector binding site; other site 930170009522 active site 930170009523 Zn binding site [ion binding]; other site 930170009524 glycine loop; other site 930170009525 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 930170009526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 930170009527 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930170009528 active site 930170009529 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 930170009530 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170009531 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170009532 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 930170009533 active site 930170009534 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 930170009535 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 930170009536 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 930170009537 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930170009538 active site 930170009539 catalytic site [active] 930170009540 substrate binding site [chemical binding]; other site 930170009541 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 930170009542 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930170009543 catalytic residues [active] 930170009544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 930170009545 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 930170009546 Probable transposase; Region: OrfB_IS605; pfam01385 930170009547 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930170009548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170009549 Walker A/P-loop; other site 930170009550 ATP binding site [chemical binding]; other site 930170009551 Q-loop/lid; other site 930170009552 ABC transporter signature motif; other site 930170009553 Walker B; other site 930170009554 D-loop; other site 930170009555 H-loop/switch region; other site 930170009556 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170009557 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170009558 aconitate hydratase; Validated; Region: PRK09277 930170009559 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 930170009560 substrate binding site [chemical binding]; other site 930170009561 ligand binding site [chemical binding]; other site 930170009562 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 930170009563 substrate binding site [chemical binding]; other site 930170009564 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 930170009565 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170009566 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 930170009567 NodB motif; other site 930170009568 active site 930170009569 catalytic site [active] 930170009570 metal binding site [ion binding]; metal-binding site 930170009571 Small acid-soluble spore protein P family; Region: SspP; cl12105 930170009572 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 930170009573 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 930170009574 putative dimer interface [polypeptide binding]; other site 930170009575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170009576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170009577 putative substrate translocation pore; other site 930170009578 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 930170009579 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930170009580 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170009581 nudix motif; other site 930170009582 SAP domain; Region: SAP; pfam02037 930170009583 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 930170009584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930170009585 dimer interface [polypeptide binding]; other site 930170009586 active site 930170009587 acyl-CoA synthetase; Validated; Region: PRK07638 930170009588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170009589 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170009590 acyl-activating enzyme (AAE) consensus motif; other site 930170009591 acyl-activating enzyme (AAE) consensus motif; other site 930170009592 AMP binding site [chemical binding]; other site 930170009593 active site 930170009594 CoA binding site [chemical binding]; other site 930170009595 BioY family; Region: BioY; pfam02632 930170009596 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 930170009597 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 930170009598 dimer interface [polypeptide binding]; other site 930170009599 acyl-activating enzyme (AAE) consensus motif; other site 930170009600 putative active site [active] 930170009601 AMP binding site [chemical binding]; other site 930170009602 putative CoA binding site [chemical binding]; other site 930170009603 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930170009604 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170009605 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 930170009606 Walker A/P-loop; other site 930170009607 ATP binding site [chemical binding]; other site 930170009608 Q-loop/lid; other site 930170009609 ABC transporter signature motif; other site 930170009610 Walker B; other site 930170009611 D-loop; other site 930170009612 H-loop/switch region; other site 930170009613 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170009614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170009615 non-specific DNA binding site [nucleotide binding]; other site 930170009616 salt bridge; other site 930170009617 sequence-specific DNA binding site [nucleotide binding]; other site 930170009618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170009619 Coenzyme A binding pocket [chemical binding]; other site 930170009620 S-layer homology domain; Region: SLH; pfam00395 930170009621 S-layer homology domain; Region: SLH; pfam00395 930170009622 S-layer homology domain; Region: SLH; pfam00395 930170009623 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 930170009624 active site 930170009625 catalytic motif [active] 930170009626 Zn binding site [ion binding]; other site 930170009627 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 930170009628 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170009629 amidase catalytic site [active] 930170009630 Zn binding residues [ion binding]; other site 930170009631 substrate binding site [chemical binding]; other site 930170009632 active site 930170009633 Protein phosphatase 2C; Region: PP2C_2; pfam13672 930170009634 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170009635 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170009636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170009637 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 930170009638 dimer interface [polypeptide binding]; other site 930170009639 putative metal binding site [ion binding]; other site 930170009640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170009641 PAS domain; Region: PAS_9; pfam13426 930170009642 putative active site [active] 930170009643 heme pocket [chemical binding]; other site 930170009644 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 930170009645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170009646 putative active site [active] 930170009647 heme pocket [chemical binding]; other site 930170009648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170009649 dimer interface [polypeptide binding]; other site 930170009650 phosphorylation site [posttranslational modification] 930170009651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170009652 ATP binding site [chemical binding]; other site 930170009653 Mg2+ binding site [ion binding]; other site 930170009654 G-X-G motif; other site 930170009655 Predicted esterase [General function prediction only]; Region: COG0400 930170009656 putative hydrolase; Provisional; Region: PRK11460 930170009657 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930170009658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170009659 Zn binding site [ion binding]; other site 930170009660 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930170009661 Zn binding site [ion binding]; other site 930170009662 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 930170009663 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 930170009664 Na binding site [ion binding]; other site 930170009665 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 930170009666 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 930170009667 active site 930170009668 FMN binding site [chemical binding]; other site 930170009669 substrate binding site [chemical binding]; other site 930170009670 3Fe-4S cluster binding site [ion binding]; other site 930170009671 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930170009672 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 930170009673 FMN binding site [chemical binding]; other site 930170009674 active site 930170009675 substrate binding site [chemical binding]; other site 930170009676 catalytic residue [active] 930170009677 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 930170009678 agmatinase; Region: agmatinase; TIGR01230 930170009679 Agmatinase-like family; Region: Agmatinase-like; cd09990 930170009680 active site 930170009681 oligomer interface [polypeptide binding]; other site 930170009682 Mn binding site [ion binding]; other site 930170009683 imidazolonepropionase; Validated; Region: PRK09356 930170009684 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 930170009685 active site 930170009686 urocanate hydratase; Provisional; Region: PRK05414 930170009687 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 930170009688 active sites [active] 930170009689 tetramer interface [polypeptide binding]; other site 930170009690 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 930170009691 hexamer interface [polypeptide binding]; other site 930170009692 RNA binding site [nucleotide binding]; other site 930170009693 Histidine-zinc binding site [chemical binding]; other site 930170009694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170009695 S-adenosylmethionine binding site [chemical binding]; other site 930170009696 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930170009697 conserved cys residue [active] 930170009698 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 930170009699 AAA domain; Region: AAA_28; pfam13521 930170009700 active site 930170009701 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 930170009702 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009703 Domain of unknown function DUF11; Region: DUF11; cl17728 930170009704 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009705 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009706 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009707 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009708 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009709 Domain of unknown function DUF11; Region: DUF11; cl17728 930170009710 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009711 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009712 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009713 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009714 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009715 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009716 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009717 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009718 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009719 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009720 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170009721 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 930170009722 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 930170009723 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 930170009724 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930170009725 EamA-like transporter family; Region: EamA; pfam00892 930170009726 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 930170009727 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930170009728 metal binding site [ion binding]; metal-binding site 930170009729 dimer interface [polypeptide binding]; other site 930170009730 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 930170009731 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170009732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170009733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170009734 Walker A/P-loop; other site 930170009735 ATP binding site [chemical binding]; other site 930170009736 Q-loop/lid; other site 930170009737 ABC transporter signature motif; other site 930170009738 Walker B; other site 930170009739 D-loop; other site 930170009740 H-loop/switch region; other site 930170009741 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 930170009742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170009743 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 930170009744 putative dimerization interface [polypeptide binding]; other site 930170009745 putative substrate binding pocket [chemical binding]; other site 930170009746 holin-like protein; Validated; Region: PRK01658 930170009747 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 930170009748 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170009749 nudix motif; other site 930170009750 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 930170009751 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930170009752 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930170009753 amidase catalytic site [active] 930170009754 Zn binding residues [ion binding]; other site 930170009755 substrate binding site [chemical binding]; other site 930170009756 S-layer homology domain; Region: SLH; pfam00395 930170009757 S-layer homology domain; Region: SLH; pfam00395 930170009758 S-layer homology domain; Region: SLH; pfam00395 930170009759 Nuclease-related domain; Region: NERD; pfam08378 930170009760 Bacterial SH3 domain; Region: SH3_3; cl17532 930170009761 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170009762 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170009763 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930170009764 Walker A/P-loop; other site 930170009765 ATP binding site [chemical binding]; other site 930170009766 Q-loop/lid; other site 930170009767 ABC transporter signature motif; other site 930170009768 Walker B; other site 930170009769 D-loop; other site 930170009770 H-loop/switch region; other site 930170009771 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170009772 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 930170009773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170009774 Walker A/P-loop; other site 930170009775 ATP binding site [chemical binding]; other site 930170009776 Q-loop/lid; other site 930170009777 ABC transporter signature motif; other site 930170009778 Walker B; other site 930170009779 D-loop; other site 930170009780 H-loop/switch region; other site 930170009781 hypothetical protein; Provisional; Region: PRK01844 930170009782 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 930170009783 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930170009784 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930170009785 TPP-binding site [chemical binding]; other site 930170009786 dimer interface [polypeptide binding]; other site 930170009787 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930170009788 PYR/PP interface [polypeptide binding]; other site 930170009789 dimer interface [polypeptide binding]; other site 930170009790 TPP binding site [chemical binding]; other site 930170009791 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170009792 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 930170009793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170009794 dimer interface [polypeptide binding]; other site 930170009795 conserved gate region; other site 930170009796 ABC-ATPase subunit interface; other site 930170009797 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 930170009798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170009799 dimer interface [polypeptide binding]; other site 930170009800 conserved gate region; other site 930170009801 ABC-ATPase subunit interface; other site 930170009802 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 930170009803 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 930170009804 Walker A/P-loop; other site 930170009805 ATP binding site [chemical binding]; other site 930170009806 Q-loop/lid; other site 930170009807 ABC transporter signature motif; other site 930170009808 Walker B; other site 930170009809 D-loop; other site 930170009810 H-loop/switch region; other site 930170009811 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 930170009812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170009813 membrane-bound complex binding site; other site 930170009814 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930170009815 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 930170009816 active site 930170009817 metal binding site [ion binding]; metal-binding site 930170009818 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930170009819 hypothetical protein; Provisional; Region: PRK01546 930170009820 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 930170009821 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 930170009822 catalytic residues [active] 930170009823 catalytic nucleophile [active] 930170009824 LexA repressor; Validated; Region: PRK00215 930170009825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170009826 putative DNA binding site [nucleotide binding]; other site 930170009827 putative Zn2+ binding site [ion binding]; other site 930170009828 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 930170009829 Catalytic site [active] 930170009830 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 930170009831 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930170009832 potential frameshift: common BLAST hit: gi|212639483|ref|YP_002316003.1| transposase 930170009833 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 930170009834 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170009835 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170009836 glutamine synthetase, type I; Region: GlnA; TIGR00653 930170009837 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 930170009838 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 930170009839 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 930170009840 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170009841 DNA binding residues [nucleotide binding] 930170009842 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 930170009843 Aluminium resistance protein; Region: Alum_res; pfam06838 930170009844 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 930170009845 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930170009846 HflX GTPase family; Region: HflX; cd01878 930170009847 G1 box; other site 930170009848 GTP/Mg2+ binding site [chemical binding]; other site 930170009849 Switch I region; other site 930170009850 G2 box; other site 930170009851 G3 box; other site 930170009852 Switch II region; other site 930170009853 G4 box; other site 930170009854 G5 box; other site 930170009855 Predicted membrane protein [Function unknown]; Region: COG2860 930170009856 UPF0126 domain; Region: UPF0126; pfam03458 930170009857 UPF0126 domain; Region: UPF0126; pfam03458 930170009858 stage V sporulation protein K; Region: spore_V_K; TIGR02881 930170009859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170009860 Walker A motif; other site 930170009861 ATP binding site [chemical binding]; other site 930170009862 Walker B motif; other site 930170009863 arginine finger; other site 930170009864 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 930170009865 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930170009866 active site 930170009867 catalytic residues [active] 930170009868 DNA binding site [nucleotide binding] 930170009869 Int/Topo IB signature motif; other site 930170009870 Protein of unknown function (DUF3982); Region: DUF3982; pfam13138 930170009871 bacterial Hfq-like; Region: Hfq; cd01716 930170009872 hexamer interface [polypeptide binding]; other site 930170009873 Sm1 motif; other site 930170009874 RNA binding site [nucleotide binding]; other site 930170009875 Sm2 motif; other site 930170009876 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 930170009877 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 930170009878 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170009879 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170009880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930170009881 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 930170009882 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930170009883 active site 930170009884 phosphorylation site [posttranslational modification] 930170009885 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930170009886 active site 930170009887 P-loop; other site 930170009888 phosphorylation site [posttranslational modification] 930170009889 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 930170009890 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 930170009891 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930170009892 putative substrate binding site [chemical binding]; other site 930170009893 putative ATP binding site [chemical binding]; other site 930170009894 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930170009895 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930170009896 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930170009897 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 930170009898 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 930170009899 dimer interface [polypeptide binding]; other site 930170009900 active site 930170009901 metal binding site [ion binding]; metal-binding site 930170009902 Predicted membrane protein [Function unknown]; Region: COG2322 930170009903 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 930170009904 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 930170009905 Glyco_18 domain; Region: Glyco_18; smart00636 930170009906 putative active site [active] 930170009907 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930170009908 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170009909 putative active site [active] 930170009910 putative metal binding site [ion binding]; other site 930170009911 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 930170009912 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 930170009913 IHF dimer interface [polypeptide binding]; other site 930170009914 IHF - DNA interface [nucleotide binding]; other site 930170009915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170009916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170009917 Coenzyme A binding pocket [chemical binding]; other site 930170009918 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930170009919 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930170009920 metal-binding site [ion binding] 930170009921 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930170009922 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930170009923 metal-binding site [ion binding] 930170009924 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170009925 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930170009926 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930170009927 metal-binding site [ion binding] 930170009928 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 930170009929 putative homodimer interface [polypeptide binding]; other site 930170009930 putative homotetramer interface [polypeptide binding]; other site 930170009931 putative allosteric switch controlling residues; other site 930170009932 putative metal binding site [ion binding]; other site 930170009933 putative homodimer-homodimer interface [polypeptide binding]; other site 930170009934 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 930170009935 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170009936 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930170009937 Walker A/P-loop; other site 930170009938 ATP binding site [chemical binding]; other site 930170009939 Q-loop/lid; other site 930170009940 ABC transporter signature motif; other site 930170009941 Walker B; other site 930170009942 D-loop; other site 930170009943 H-loop/switch region; other site 930170009944 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930170009945 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170009946 ABC-ATPase subunit interface; other site 930170009947 dimer interface [polypeptide binding]; other site 930170009948 putative PBP binding regions; other site 930170009949 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170009950 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170009951 ABC-ATPase subunit interface; other site 930170009952 dimer interface [polypeptide binding]; other site 930170009953 putative PBP binding regions; other site 930170009954 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170009955 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 930170009956 putative ligand binding residues [chemical binding]; other site 930170009957 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 930170009958 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 930170009959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170009960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170009961 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 930170009962 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930170009963 DNA binding site [nucleotide binding] 930170009964 active site 930170009965 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 930170009966 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930170009967 endonuclease III; Region: ENDO3c; smart00478 930170009968 minor groove reading motif; other site 930170009969 helix-hairpin-helix signature motif; other site 930170009970 substrate binding pocket [chemical binding]; other site 930170009971 active site 930170009972 peptidase T; Region: peptidase-T; TIGR01882 930170009973 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 930170009974 metal binding site [ion binding]; metal-binding site 930170009975 dimer interface [polypeptide binding]; other site 930170009976 Predicted membrane protein [Function unknown]; Region: COG2364 930170009977 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170009978 hypothetical protein; Provisional; Region: PRK06764 930170009979 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170009980 catalytic core [active] 930170009981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170009982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170009983 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930170009984 active site 930170009985 PAS domain S-box; Region: sensory_box; TIGR00229 930170009986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170009987 putative active site [active] 930170009988 heme pocket [chemical binding]; other site 930170009989 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170009990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170009991 metal binding site [ion binding]; metal-binding site 930170009992 active site 930170009993 I-site; other site 930170009994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170009995 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 930170009996 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 930170009997 active site 930170009998 homodimer interface [polypeptide binding]; other site 930170009999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170010000 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 930170010001 NAD(P) binding site [chemical binding]; other site 930170010002 active site 930170010003 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 930170010004 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 930170010005 NAD(P) binding site [chemical binding]; other site 930170010006 homodimer interface [polypeptide binding]; other site 930170010007 substrate binding site [chemical binding]; other site 930170010008 active site 930170010009 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 930170010010 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 930170010011 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930170010012 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 930170010013 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 930170010014 holin-like protein; Validated; Region: PRK01658 930170010015 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930170010016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170010017 DNA-binding site [nucleotide binding]; DNA binding site 930170010018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170010019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170010020 homodimer interface [polypeptide binding]; other site 930170010021 catalytic residue [active] 930170010022 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 930170010023 active site 930170010024 catalytic site [active] 930170010025 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 930170010026 putative active site [active] 930170010027 putative catalytic triad [active] 930170010028 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 930170010029 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170010030 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 930170010031 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170010032 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 930170010033 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 930170010034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930170010035 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930170010036 Sulfatase; Region: Sulfatase; pfam00884 930170010037 Tetratricopeptide repeat; Region: TPR_16; pfam13432 930170010038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170010039 binding surface 930170010040 TPR motif; other site 930170010041 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930170010042 G1 box; other site 930170010043 GTP/Mg2+ binding site [chemical binding]; other site 930170010044 Switch I region; other site 930170010045 G3 box; other site 930170010046 Switch II region; other site 930170010047 G4 box; other site 930170010048 G5 box; other site 930170010049 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 930170010050 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 930170010051 active site 930170010052 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 930170010053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170010054 ATP binding site [chemical binding]; other site 930170010055 Mg2+ binding site [ion binding]; other site 930170010056 G-X-G motif; other site 930170010057 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 930170010058 ATP binding site [chemical binding]; other site 930170010059 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 930170010060 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 930170010061 MutS domain I; Region: MutS_I; pfam01624 930170010062 MutS domain II; Region: MutS_II; pfam05188 930170010063 MutS domain III; Region: MutS_III; pfam05192 930170010064 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 930170010065 Walker A/P-loop; other site 930170010066 ATP binding site [chemical binding]; other site 930170010067 Q-loop/lid; other site 930170010068 ABC transporter signature motif; other site 930170010069 Walker B; other site 930170010070 D-loop; other site 930170010071 H-loop/switch region; other site 930170010072 Outer spore coat protein E (CotE); Region: CotE; pfam10628 930170010073 Predicted membrane protein [Function unknown]; Region: COG4550 930170010074 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 930170010075 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 930170010076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170010077 FeS/SAM binding site; other site 930170010078 TRAM domain; Region: TRAM; pfam01938 930170010079 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 930170010080 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 930170010081 TPP-binding site [chemical binding]; other site 930170010082 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 930170010083 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 930170010084 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 930170010085 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 930170010086 dimer interface [polypeptide binding]; other site 930170010087 PYR/PP interface [polypeptide binding]; other site 930170010088 TPP binding site [chemical binding]; other site 930170010089 substrate binding site [chemical binding]; other site 930170010090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170010091 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 930170010092 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 930170010093 active site 930170010094 dimer interface [polypeptide binding]; other site 930170010095 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 930170010096 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 930170010097 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930170010098 putative active site [active] 930170010099 metal binding site [ion binding]; metal-binding site 930170010100 homodimer binding site [polypeptide binding]; other site 930170010101 phosphodiesterase; Provisional; Region: PRK12704 930170010102 Uncharacterized conserved protein [Function unknown]; Region: COG3334 930170010103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170010104 Zn2+ binding site [ion binding]; other site 930170010105 Mg2+ binding site [ion binding]; other site 930170010106 recA bacterial DNA recombination protein; Region: RecA; cl17211 930170010107 recA bacterial DNA recombination protein; Region: RecA; cl17211 930170010108 competence damage-inducible protein A; Provisional; Region: PRK00549 930170010109 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 930170010110 putative MPT binding site; other site 930170010111 Competence-damaged protein; Region: CinA; pfam02464 930170010112 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 930170010113 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 930170010114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170010115 non-specific DNA binding site [nucleotide binding]; other site 930170010116 salt bridge; other site 930170010117 sequence-specific DNA binding site [nucleotide binding]; other site 930170010118 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 930170010119 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 930170010120 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 930170010121 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 930170010122 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 930170010123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170010124 NAD(P) binding site [chemical binding]; other site 930170010125 active site 930170010126 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930170010127 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 930170010128 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930170010129 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930170010130 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930170010131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170010132 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930170010133 TM-ABC transporter signature motif; other site 930170010134 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930170010135 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930170010136 TM-ABC transporter signature motif; other site 930170010137 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 930170010138 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930170010139 Walker A/P-loop; other site 930170010140 ATP binding site [chemical binding]; other site 930170010141 Q-loop/lid; other site 930170010142 ABC transporter signature motif; other site 930170010143 Walker B; other site 930170010144 D-loop; other site 930170010145 H-loop/switch region; other site 930170010146 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930170010147 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 930170010148 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 930170010149 ligand binding site [chemical binding]; other site 930170010150 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930170010151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170010152 DNA-binding site [nucleotide binding]; DNA binding site 930170010153 UTRA domain; Region: UTRA; pfam07702 930170010154 Tetraspanin family; Region: Tetraspannin; pfam00335 930170010155 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930170010156 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930170010157 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930170010158 YlzJ-like protein; Region: YlzJ; pfam14035 930170010159 Clp protease; Region: CLP_protease; pfam00574 930170010160 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 930170010161 active site 930170010162 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930170010163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170010164 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930170010165 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 930170010166 dihydrodipicolinate synthase; Region: dapA; TIGR00674 930170010167 dimer interface [polypeptide binding]; other site 930170010168 active site 930170010169 catalytic residue [active] 930170010170 aspartate kinase I; Reviewed; Region: PRK08210 930170010171 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 930170010172 nucleotide binding site [chemical binding]; other site 930170010173 substrate binding site [chemical binding]; other site 930170010174 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 930170010175 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 930170010176 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 930170010177 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930170010178 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 930170010179 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 930170010180 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 930170010181 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 930170010182 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930170010183 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 930170010184 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930170010185 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 930170010186 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 930170010187 NodB motif; other site 930170010188 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 930170010189 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 930170010190 RNase E interface [polypeptide binding]; other site 930170010191 trimer interface [polypeptide binding]; other site 930170010192 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 930170010193 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 930170010194 RNase E interface [polypeptide binding]; other site 930170010195 trimer interface [polypeptide binding]; other site 930170010196 active site 930170010197 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 930170010198 putative nucleic acid binding region [nucleotide binding]; other site 930170010199 G-X-X-G motif; other site 930170010200 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 930170010201 RNA binding site [nucleotide binding]; other site 930170010202 domain interface; other site 930170010203 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 930170010204 16S/18S rRNA binding site [nucleotide binding]; other site 930170010205 S13e-L30e interaction site [polypeptide binding]; other site 930170010206 25S rRNA binding site [nucleotide binding]; other site 930170010207 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 930170010208 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 930170010209 active site 930170010210 Riboflavin kinase; Region: Flavokinase; pfam01687 930170010211 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 930170010212 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 930170010213 RNA binding site [nucleotide binding]; other site 930170010214 active site 930170010215 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 930170010216 Protein of unknown function (DUF503); Region: DUF503; pfam04456 930170010217 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930170010218 translation initiation factor IF-2; Region: IF-2; TIGR00487 930170010219 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930170010220 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 930170010221 G1 box; other site 930170010222 putative GEF interaction site [polypeptide binding]; other site 930170010223 GTP/Mg2+ binding site [chemical binding]; other site 930170010224 Switch I region; other site 930170010225 G2 box; other site 930170010226 G3 box; other site 930170010227 Switch II region; other site 930170010228 G4 box; other site 930170010229 G5 box; other site 930170010230 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 930170010231 Translation-initiation factor 2; Region: IF-2; pfam11987 930170010232 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 930170010233 hypothetical protein; Provisional; Region: PRK07714 930170010234 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 930170010235 putative RNA binding cleft [nucleotide binding]; other site 930170010236 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 930170010237 NusA N-terminal domain; Region: NusA_N; pfam08529 930170010238 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 930170010239 RNA binding site [nucleotide binding]; other site 930170010240 homodimer interface [polypeptide binding]; other site 930170010241 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 930170010242 G-X-X-G motif; other site 930170010243 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 930170010244 G-X-X-G motif; other site 930170010245 ribosome maturation protein RimP; Reviewed; Region: PRK00092 930170010246 Sm and related proteins; Region: Sm_like; cl00259 930170010247 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 930170010248 putative oligomer interface [polypeptide binding]; other site 930170010249 putative RNA binding site [nucleotide binding]; other site 930170010250 DNA polymerase III PolC; Validated; Region: polC; PRK00448 930170010251 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170010252 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170010253 putative active site [active] 930170010254 putative NTP binding site [chemical binding]; other site 930170010255 putative nucleic acid binding site [nucleotide binding]; other site 930170010256 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930170010257 active site 930170010258 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 930170010259 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 930170010260 generic binding surface II; other site 930170010261 generic binding surface I; other site 930170010262 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 930170010263 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 930170010264 active site 930170010265 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 930170010266 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930170010267 active site 930170010268 catalytic site [active] 930170010269 substrate binding site [chemical binding]; other site 930170010270 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 930170010271 prolyl-tRNA synthetase; Provisional; Region: PRK09194 930170010272 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 930170010273 dimer interface [polypeptide binding]; other site 930170010274 motif 1; other site 930170010275 active site 930170010276 motif 2; other site 930170010277 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 930170010278 putative deacylase active site [active] 930170010279 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930170010280 active site 930170010281 motif 3; other site 930170010282 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 930170010283 anticodon binding site; other site 930170010284 RIP metalloprotease RseP; Region: TIGR00054 930170010285 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930170010286 active site 930170010287 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 930170010288 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 930170010289 protein binding site [polypeptide binding]; other site 930170010290 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930170010291 putative substrate binding region [chemical binding]; other site 930170010292 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 930170010293 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 930170010294 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 930170010295 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 930170010296 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 930170010297 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 930170010298 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 930170010299 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 930170010300 catalytic residue [active] 930170010301 putative FPP diphosphate binding site; other site 930170010302 putative FPP binding hydrophobic cleft; other site 930170010303 dimer interface [polypeptide binding]; other site 930170010304 putative IPP diphosphate binding site; other site 930170010305 ribosome recycling factor; Reviewed; Region: frr; PRK00083 930170010306 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 930170010307 hinge region; other site 930170010308 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 930170010309 putative nucleotide binding site [chemical binding]; other site 930170010310 uridine monophosphate binding site [chemical binding]; other site 930170010311 homohexameric interface [polypeptide binding]; other site 930170010312 elongation factor Ts; Provisional; Region: tsf; PRK09377 930170010313 UBA/TS-N domain; Region: UBA; pfam00627 930170010314 Elongation factor TS; Region: EF_TS; pfam00889 930170010315 Elongation factor TS; Region: EF_TS; pfam00889 930170010316 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 930170010317 rRNA interaction site [nucleotide binding]; other site 930170010318 S8 interaction site; other site 930170010319 putative laminin-1 binding site; other site 930170010320 transcriptional repressor CodY; Validated; Region: PRK04158 930170010321 CodY GAF-like domain; Region: CodY; pfam06018 930170010322 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 930170010323 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 930170010324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170010325 Walker A motif; other site 930170010326 ATP binding site [chemical binding]; other site 930170010327 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 930170010328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930170010329 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 930170010330 active site 930170010331 HslU subunit interaction site [polypeptide binding]; other site 930170010332 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 930170010333 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 930170010334 active site 930170010335 Int/Topo IB signature motif; other site 930170010336 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 930170010337 Glucose inhibited division protein A; Region: GIDA; pfam01134 930170010338 DNA topoisomerase I; Validated; Region: PRK05582 930170010339 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 930170010340 active site 930170010341 interdomain interaction site; other site 930170010342 putative metal-binding site [ion binding]; other site 930170010343 nucleotide binding site [chemical binding]; other site 930170010344 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930170010345 domain I; other site 930170010346 DNA binding groove [nucleotide binding] 930170010347 phosphate binding site [ion binding]; other site 930170010348 domain II; other site 930170010349 domain III; other site 930170010350 nucleotide binding site [chemical binding]; other site 930170010351 catalytic site [active] 930170010352 domain IV; other site 930170010353 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930170010354 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930170010355 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 930170010356 DNA protecting protein DprA; Region: dprA; TIGR00732 930170010357 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 930170010358 CoA binding domain; Region: CoA_binding; smart00881 930170010359 CoA-ligase; Region: Ligase_CoA; pfam00549 930170010360 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 930170010361 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 930170010362 CoA-ligase; Region: Ligase_CoA; pfam00549 930170010363 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 930170010364 RNA/DNA hybrid binding site [nucleotide binding]; other site 930170010365 active site 930170010366 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 930170010367 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 930170010368 GTP/Mg2+ binding site [chemical binding]; other site 930170010369 G4 box; other site 930170010370 G5 box; other site 930170010371 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 930170010372 G1 box; other site 930170010373 G1 box; other site 930170010374 GTP/Mg2+ binding site [chemical binding]; other site 930170010375 Switch I region; other site 930170010376 G2 box; other site 930170010377 G2 box; other site 930170010378 G3 box; other site 930170010379 G3 box; other site 930170010380 Switch II region; other site 930170010381 Switch II region; other site 930170010382 G4 box; other site 930170010383 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930170010384 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170010385 Catalytic site [active] 930170010386 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930170010387 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 930170010388 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 930170010389 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 930170010390 RimM N-terminal domain; Region: RimM; pfam01782 930170010391 PRC-barrel domain; Region: PRC; pfam05239 930170010392 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 930170010393 KH domain; Region: KH_4; pfam13083 930170010394 G-X-X-G motif; other site 930170010395 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 930170010396 signal recognition particle protein; Provisional; Region: PRK10867 930170010397 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 930170010398 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930170010399 P loop; other site 930170010400 GTP binding site [chemical binding]; other site 930170010401 Signal peptide binding domain; Region: SRP_SPB; pfam02978 930170010402 putative DNA-binding protein; Validated; Region: PRK00118 930170010403 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 930170010404 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 930170010405 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 930170010406 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930170010407 P loop; other site 930170010408 GTP binding site [chemical binding]; other site 930170010409 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 930170010410 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930170010411 Walker A/P-loop; other site 930170010412 ATP binding site [chemical binding]; other site 930170010413 Q-loop/lid; other site 930170010414 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 930170010415 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930170010416 ABC transporter signature motif; other site 930170010417 Walker B; other site 930170010418 D-loop; other site 930170010419 H-loop/switch region; other site 930170010420 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 930170010421 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 930170010422 dimerization interface [polypeptide binding]; other site 930170010423 active site 930170010424 metal binding site [ion binding]; metal-binding site 930170010425 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 930170010426 dsRNA binding site [nucleotide binding]; other site 930170010427 acyl carrier protein; Provisional; Region: acpP; PRK00982 930170010428 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 930170010429 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 930170010430 NAD(P) binding site [chemical binding]; other site 930170010431 homotetramer interface [polypeptide binding]; other site 930170010432 homodimer interface [polypeptide binding]; other site 930170010433 active site 930170010434 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 930170010435 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 930170010436 putative phosphate acyltransferase; Provisional; Region: PRK05331 930170010437 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 930170010438 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 930170010439 active site 2 [active] 930170010440 active site 1 [active] 930170010441 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 930170010442 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 930170010443 generic binding surface II; other site 930170010444 ssDNA binding site; other site 930170010445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170010446 ATP binding site [chemical binding]; other site 930170010447 putative Mg++ binding site [ion binding]; other site 930170010448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170010449 nucleotide binding region [chemical binding]; other site 930170010450 ATP-binding site [chemical binding]; other site 930170010451 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 930170010452 DAK2 domain; Region: Dak2; pfam02734 930170010453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 930170010454 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 930170010455 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 930170010456 Thiamine pyrophosphokinase; Region: TPK; cd07995 930170010457 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 930170010458 active site 930170010459 dimerization interface [polypeptide binding]; other site 930170010460 thiamine binding site [chemical binding]; other site 930170010461 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930170010462 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930170010463 substrate binding site [chemical binding]; other site 930170010464 hexamer interface [polypeptide binding]; other site 930170010465 metal binding site [ion binding]; metal-binding site 930170010466 GTPase RsgA; Reviewed; Region: PRK00098 930170010467 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 930170010468 RNA binding site [nucleotide binding]; other site 930170010469 homodimer interface [polypeptide binding]; other site 930170010470 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930170010471 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930170010472 GTP/Mg2+ binding site [chemical binding]; other site 930170010473 G4 box; other site 930170010474 G5 box; other site 930170010475 G1 box; other site 930170010476 Switch I region; other site 930170010477 G2 box; other site 930170010478 G3 box; other site 930170010479 Switch II region; other site 930170010480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930170010481 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930170010482 active site 930170010483 ATP binding site [chemical binding]; other site 930170010484 substrate binding site [chemical binding]; other site 930170010485 activation loop (A-loop); other site 930170010486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 930170010487 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930170010488 PASTA domain; Region: PASTA; pfam03793 930170010489 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930170010490 Protein phosphatase 2C; Region: PP2C; pfam00481 930170010491 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 930170010492 active site 930170010493 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 930170010494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170010495 FeS/SAM binding site; other site 930170010496 16S rRNA methyltransferase B; Provisional; Region: PRK14902 930170010497 NusB family; Region: NusB; pfam01029 930170010498 putative RNA binding site [nucleotide binding]; other site 930170010499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170010500 S-adenosylmethionine binding site [chemical binding]; other site 930170010501 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 930170010502 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 930170010503 putative active site [active] 930170010504 substrate binding site [chemical binding]; other site 930170010505 putative cosubstrate binding site; other site 930170010506 catalytic site [active] 930170010507 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 930170010508 substrate binding site [chemical binding]; other site 930170010509 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930170010510 active site 930170010511 catalytic residues [active] 930170010512 metal binding site [ion binding]; metal-binding site 930170010513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170010514 primosomal protein N' Region: priA; TIGR00595 930170010515 ATP binding site [chemical binding]; other site 930170010516 putative Mg++ binding site [ion binding]; other site 930170010517 helicase superfamily c-terminal domain; Region: HELICc; smart00490 930170010518 nucleotide binding region [chemical binding]; other site 930170010519 ATP-binding site [chemical binding]; other site 930170010520 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 930170010521 Flavoprotein; Region: Flavoprotein; pfam02441 930170010522 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 930170010523 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 930170010524 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 930170010525 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 930170010526 catalytic site [active] 930170010527 G-X2-G-X-G-K; other site 930170010528 hypothetical protein; Provisional; Region: PRK04323 930170010529 hypothetical protein; Provisional; Region: PRK11820 930170010530 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 930170010531 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 930170010532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930170010533 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 930170010534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170010535 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930170010536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170010537 motif II; other site 930170010538 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930170010539 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 930170010540 Domain of unknown function (DUF814); Region: DUF814; pfam05670 930170010541 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930170010542 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930170010543 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930170010544 active site 930170010545 Protein of unknown function (DUF664); Region: DUF664; pfam04978 930170010546 DinB superfamily; Region: DinB_2; pfam12867 930170010547 YoqO-like protein; Region: YoqO; pfam14037 930170010548 YoqO-like protein; Region: YoqO; pfam14037 930170010549 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 930170010550 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 930170010551 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 930170010552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170010553 motif II; other site 930170010554 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170010555 active site 930170010556 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 930170010557 active site 930170010558 dimer interface [polypeptide binding]; other site 930170010559 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 930170010560 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 930170010561 heterodimer interface [polypeptide binding]; other site 930170010562 active site 930170010563 FMN binding site [chemical binding]; other site 930170010564 homodimer interface [polypeptide binding]; other site 930170010565 substrate binding site [chemical binding]; other site 930170010566 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 930170010567 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 930170010568 FAD binding pocket [chemical binding]; other site 930170010569 FAD binding motif [chemical binding]; other site 930170010570 phosphate binding motif [ion binding]; other site 930170010571 beta-alpha-beta structure motif; other site 930170010572 NAD binding pocket [chemical binding]; other site 930170010573 Iron coordination center [ion binding]; other site 930170010574 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 930170010575 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930170010576 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930170010577 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 930170010578 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930170010579 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930170010580 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 930170010581 IMP binding site; other site 930170010582 dimer interface [polypeptide binding]; other site 930170010583 interdomain contacts; other site 930170010584 partial ornithine binding site; other site 930170010585 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 930170010586 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 930170010587 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 930170010588 catalytic site [active] 930170010589 subunit interface [polypeptide binding]; other site 930170010590 dihydroorotase; Validated; Region: pyrC; PRK09357 930170010591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930170010592 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 930170010593 active site 930170010594 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 930170010595 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930170010596 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930170010597 uracil transporter; Provisional; Region: PRK10720 930170010598 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 930170010599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170010600 active site 930170010601 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 930170010602 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170010603 RNA binding surface [nucleotide binding]; other site 930170010604 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930170010605 active site 930170010606 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 930170010607 lipoprotein signal peptidase; Provisional; Region: PRK14787 930170010608 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 930170010609 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 930170010610 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930170010611 active site 930170010612 HIGH motif; other site 930170010613 nucleotide binding site [chemical binding]; other site 930170010614 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930170010615 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930170010616 active site 930170010617 KMSKS motif; other site 930170010618 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 930170010619 tRNA binding surface [nucleotide binding]; other site 930170010620 anticodon binding site; other site 930170010621 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930170010622 DivIVA protein; Region: DivIVA; pfam05103 930170010623 DivIVA domain; Region: DivI1A_domain; TIGR03544 930170010624 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 930170010625 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 930170010626 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170010627 RNA binding surface [nucleotide binding]; other site 930170010628 YGGT family; Region: YGGT; pfam02325 930170010629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 930170010630 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 930170010631 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930170010632 catalytic residue [active] 930170010633 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 930170010634 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 930170010635 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 930170010636 sporulation sigma factor SigG; Reviewed; Region: PRK08215 930170010637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170010638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170010639 DNA binding residues [nucleotide binding] 930170010640 sporulation sigma factor SigE; Reviewed; Region: PRK08301 930170010641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170010642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170010643 DNA binding residues [nucleotide binding] 930170010644 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 930170010645 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 930170010646 cell division protein FtsZ; Validated; Region: PRK09330 930170010647 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 930170010648 nucleotide binding site [chemical binding]; other site 930170010649 SulA interaction site; other site 930170010650 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 930170010651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930170010652 nucleotide binding site [chemical binding]; other site 930170010653 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 930170010654 Cell division protein FtsA; Region: FtsA; pfam14450 930170010655 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 930170010656 Cell division protein FtsQ; Region: FtsQ; pfam03799 930170010657 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 930170010658 FAD binding domain; Region: FAD_binding_4; pfam01565 930170010659 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 930170010660 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 930170010661 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 930170010662 active site 930170010663 homodimer interface [polypeptide binding]; other site 930170010664 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 930170010665 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 930170010666 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 930170010667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930170010668 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930170010669 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 930170010670 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 930170010671 Mg++ binding site [ion binding]; other site 930170010672 putative catalytic motif [active] 930170010673 putative substrate binding site [chemical binding]; other site 930170010674 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 930170010675 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930170010676 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930170010677 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930170010678 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 930170010679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170010680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170010681 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 930170010682 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170010683 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170010684 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170010685 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 930170010686 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 930170010687 Cell division protein FtsL; Region: FtsL; cl11433 930170010688 MraW methylase family; Region: Methyltransf_5; pfam01795 930170010689 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 930170010690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 930170010691 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 930170010692 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 930170010693 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 930170010694 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 930170010695 hypothetical protein; Provisional; Region: PRK13688 930170010696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930170010697 Coenzyme A binding pocket [chemical binding]; other site 930170010698 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 930170010699 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 930170010700 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 930170010701 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 930170010702 hypothetical protein; Provisional; Region: PRK13670 930170010703 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 930170010704 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 930170010705 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 930170010706 protein binding site [polypeptide binding]; other site 930170010707 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 930170010708 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 930170010709 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 930170010710 active site 930170010711 nucleophile elbow; other site 930170010712 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 930170010713 Nucleoside recognition; Region: Gate; pfam07670 930170010714 Nucleoside recognition; Region: Gate; pfam07670 930170010715 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 930170010716 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 930170010717 active site 930170010718 (T/H)XGH motif; other site 930170010719 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 930170010720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170010721 S-adenosylmethionine binding site [chemical binding]; other site 930170010722 hypothetical protein; Provisional; Region: PRK02886 930170010723 Protein of unknown function (DUF964); Region: DUF964; pfam06133 930170010724 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170010725 catalytic core [active] 930170010726 YlbE-like protein; Region: YlbE; pfam14003 930170010727 Putative coat protein; Region: YlbD_coat; pfam14071 930170010728 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 930170010729 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 930170010730 YugN-like family; Region: YugN; pfam08868 930170010731 formamidase; Provisional; Region: amiF; PRK13287 930170010732 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 930170010733 multimer interface [polypeptide binding]; other site 930170010734 active site 930170010735 catalytic triad [active] 930170010736 dimer interface [polypeptide binding]; other site 930170010737 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 930170010738 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 930170010739 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 930170010740 Subunit I/III interface [polypeptide binding]; other site 930170010741 Subunit III/IV interface [polypeptide binding]; other site 930170010742 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 930170010743 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 930170010744 D-pathway; other site 930170010745 Putative ubiquinol binding site [chemical binding]; other site 930170010746 Low-spin heme (heme b) binding site [chemical binding]; other site 930170010747 Putative water exit pathway; other site 930170010748 Binuclear center (heme o3/CuB) [ion binding]; other site 930170010749 K-pathway; other site 930170010750 Putative proton exit pathway; other site 930170010751 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 930170010752 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 930170010753 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 930170010754 Cytochrome c; Region: Cytochrom_C; pfam00034 930170010755 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 930170010756 UbiA prenyltransferase family; Region: UbiA; pfam01040 930170010757 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 930170010758 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 930170010759 pyruvate carboxylase; Reviewed; Region: PRK12999 930170010760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930170010761 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930170010762 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930170010763 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 930170010764 active site 930170010765 catalytic residues [active] 930170010766 metal binding site [ion binding]; metal-binding site 930170010767 homodimer binding site [polypeptide binding]; other site 930170010768 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930170010769 carboxyltransferase (CT) interaction site; other site 930170010770 biotinylation site [posttranslational modification]; other site 930170010771 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930170010772 hypothetical protein; Provisional; Region: PRK13666 930170010773 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 930170010774 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 930170010775 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 930170010776 putative active site [active] 930170010777 PhoH-like protein; Region: PhoH; pfam02562 930170010778 hypothetical protein; Provisional; Region: PRK06733 930170010779 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 930170010780 YlaH-like protein; Region: YlaH; pfam14036 930170010781 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 930170010782 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 930170010783 G1 box; other site 930170010784 putative GEF interaction site [polypeptide binding]; other site 930170010785 GTP/Mg2+ binding site [chemical binding]; other site 930170010786 Switch I region; other site 930170010787 G2 box; other site 930170010788 G3 box; other site 930170010789 Switch II region; other site 930170010790 G4 box; other site 930170010791 G5 box; other site 930170010792 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 930170010793 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 930170010794 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 930170010795 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 930170010796 active site 930170010797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 930170010798 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 930170010799 hypothetical protein; Provisional; Region: PRK04387 930170010800 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 930170010801 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 930170010802 homodimer interface [polypeptide binding]; other site 930170010803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170010804 catalytic residue [active] 930170010805 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 930170010806 transglutaminase; Provisional; Region: tgl; PRK03187 930170010807 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 930170010808 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 930170010809 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 930170010810 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 930170010811 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 930170010812 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 930170010813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170010814 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930170010815 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930170010816 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930170010817 E3 interaction surface; other site 930170010818 lipoyl attachment site [posttranslational modification]; other site 930170010819 e3 binding domain; Region: E3_binding; pfam02817 930170010820 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930170010821 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930170010822 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930170010823 alpha subunit interface [polypeptide binding]; other site 930170010824 TPP binding site [chemical binding]; other site 930170010825 heterodimer interface [polypeptide binding]; other site 930170010826 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170010827 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 930170010828 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930170010829 TPP-binding site [chemical binding]; other site 930170010830 heterodimer interface [polypeptide binding]; other site 930170010831 tetramer interface [polypeptide binding]; other site 930170010832 phosphorylation loop region [posttranslational modification] 930170010833 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930170010834 active site 930170010835 catalytic residues [active] 930170010836 metal binding site [ion binding]; metal-binding site 930170010837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170010838 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170010839 active site 930170010840 motif I; other site 930170010841 motif II; other site 930170010842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170010843 hypothetical protein; Provisional; Region: PRK13667 930170010844 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930170010845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170010846 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930170010847 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930170010848 TrkA-N domain; Region: TrkA_N; pfam02254 930170010849 TrkA-C domain; Region: TrkA_C; pfam02080 930170010850 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930170010851 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 930170010852 metal binding site [ion binding]; metal-binding site 930170010853 putative dimer interface [polypeptide binding]; other site 930170010854 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 930170010855 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 930170010856 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 930170010857 trimer interface [polypeptide binding]; other site 930170010858 active site 930170010859 substrate binding site [chemical binding]; other site 930170010860 CoA binding site [chemical binding]; other site 930170010861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170010862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170010863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170010864 dimerization interface [polypeptide binding]; other site 930170010865 FOG: CBS domain [General function prediction only]; Region: COG0517 930170010866 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 930170010867 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 930170010868 Protein of unknown function (DUF458); Region: DUF458; pfam04308 930170010869 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 930170010870 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930170010871 catalytic residues [active] 930170010872 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 930170010873 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170010874 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 930170010875 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 930170010876 short chain dehydrogenase; Provisional; Region: PRK07677 930170010877 NAD(P) binding site [chemical binding]; other site 930170010878 substrate binding site [chemical binding]; other site 930170010879 homotetramer interface [polypeptide binding]; other site 930170010880 active site 930170010881 homodimer interface [polypeptide binding]; other site 930170010882 phosphodiesterase YaeI; Provisional; Region: PRK11340 930170010883 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930170010884 putative active site [active] 930170010885 putative metal binding site [ion binding]; other site 930170010886 polyphosphate kinase; Provisional; Region: PRK05443 930170010887 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 930170010888 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 930170010889 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 930170010890 putative domain interface [polypeptide binding]; other site 930170010891 putative active site [active] 930170010892 catalytic site [active] 930170010893 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 930170010894 putative domain interface [polypeptide binding]; other site 930170010895 putative active site [active] 930170010896 catalytic site [active] 930170010897 exopolyphosphatase; Region: exo_poly_only; TIGR03706 930170010898 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 930170010899 YkyB-like protein; Region: YkyB; pfam14177 930170010900 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 930170010901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170010902 I-site; other site 930170010903 active site 930170010904 metal binding site [ion binding]; metal-binding site 930170010905 Phage lysis protein, holin; Region: Phage_holin; cl04675 930170010906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170010907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170010908 putative substrate translocation pore; other site 930170010909 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170010910 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930170010911 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 930170010912 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 930170010913 THF binding site; other site 930170010914 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 930170010915 substrate binding site [chemical binding]; other site 930170010916 THF binding site; other site 930170010917 zinc-binding site [ion binding]; other site 930170010918 Competence protein J (ComJ); Region: ComJ; pfam11033 930170010919 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 930170010920 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 930170010921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170010922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170010923 dimer interface [polypeptide binding]; other site 930170010924 phosphorylation site [posttranslational modification] 930170010925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170010926 ATP binding site [chemical binding]; other site 930170010927 Mg2+ binding site [ion binding]; other site 930170010928 G-X-G motif; other site 930170010929 aminotransferase A; Validated; Region: PRK07683 930170010930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170010931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170010932 homodimer interface [polypeptide binding]; other site 930170010933 catalytic residue [active] 930170010934 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170010935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170010936 DNA binding site [nucleotide binding] 930170010937 domain linker motif; other site 930170010938 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 930170010939 putative dimerization interface [polypeptide binding]; other site 930170010940 putative ligand binding site [chemical binding]; other site 930170010941 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930170010942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170010943 dimer interface [polypeptide binding]; other site 930170010944 conserved gate region; other site 930170010945 putative PBP binding loops; other site 930170010946 ABC-ATPase subunit interface; other site 930170010947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170010948 dimer interface [polypeptide binding]; other site 930170010949 conserved gate region; other site 930170010950 putative PBP binding loops; other site 930170010951 ABC-ATPase subunit interface; other site 930170010952 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 930170010953 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930170010954 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 930170010955 homodimer interface [polypeptide binding]; other site 930170010956 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 930170010957 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930170010958 active site 930170010959 homodimer interface [polypeptide binding]; other site 930170010960 catalytic site [active] 930170010961 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930170010962 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930170010963 Ca binding site [ion binding]; other site 930170010964 active site 930170010965 catalytic site [active] 930170010966 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 930170010967 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 930170010968 Walker A/P-loop; other site 930170010969 ATP binding site [chemical binding]; other site 930170010970 Q-loop/lid; other site 930170010971 ABC transporter signature motif; other site 930170010972 Walker B; other site 930170010973 D-loop; other site 930170010974 H-loop/switch region; other site 930170010975 TOBE domain; Region: TOBE_2; pfam08402 930170010976 hypothetical protein; Provisional; Region: PRK06720 930170010977 NAD(P) binding site [chemical binding]; other site 930170010978 RDD family; Region: RDD; pfam06271 930170010979 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 930170010980 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 930170010981 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 930170010982 Predicted ATPase [General function prediction only]; Region: COG3910 930170010983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170010984 Walker A/P-loop; other site 930170010985 ATP binding site [chemical binding]; other site 930170010986 Q-loop/lid; other site 930170010987 ABC transporter signature motif; other site 930170010988 Walker B; other site 930170010989 D-loop; other site 930170010990 H-loop/switch region; other site 930170010991 putative acyltransferase; Provisional; Region: PRK05790 930170010992 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930170010993 dimer interface [polypeptide binding]; other site 930170010994 active site 930170010995 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 930170010996 nudix motif; other site 930170010997 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 930170010998 hypothetical protein; Validated; Region: PRK07668 930170010999 hypothetical protein; Validated; Region: PRK07668 930170011000 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170011001 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930170011002 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 930170011003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170011004 NAD(P) binding site [chemical binding]; other site 930170011005 active site 930170011006 YvrJ protein family; Region: YvrJ; pfam12841 930170011007 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 930170011008 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 930170011009 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 930170011010 Phosphotransferase enzyme family; Region: APH; pfam01636 930170011011 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930170011012 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 930170011013 putative active site [active] 930170011014 catalytic triad [active] 930170011015 putative dimer interface [polypeptide binding]; other site 930170011016 transaminase; Reviewed; Region: PRK08068 930170011017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170011018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011019 homodimer interface [polypeptide binding]; other site 930170011020 catalytic residue [active] 930170011021 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 930170011022 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 930170011023 dimer interface [polypeptide binding]; other site 930170011024 active site 930170011025 catalytic residue [active] 930170011026 metal binding site [ion binding]; metal-binding site 930170011027 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 930170011028 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 930170011029 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 930170011030 intersubunit interface [polypeptide binding]; other site 930170011031 active site 930170011032 Zn2+ binding site [ion binding]; other site 930170011033 ARD/ARD' family; Region: ARD; pfam03079 930170011034 Cupin domain; Region: Cupin_2; pfam07883 930170011035 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 930170011036 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 930170011037 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930170011038 Beta-lactamase; Region: Beta-lactamase; pfam00144 930170011039 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930170011040 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170011041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170011042 metal binding site [ion binding]; metal-binding site 930170011043 active site 930170011044 I-site; other site 930170011045 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 930170011046 dimer interface [polypeptide binding]; other site 930170011047 FMN binding site [chemical binding]; other site 930170011048 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 930170011049 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 930170011050 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 930170011051 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930170011052 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930170011053 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930170011054 dimerization domain swap beta strand [polypeptide binding]; other site 930170011055 regulatory protein interface [polypeptide binding]; other site 930170011056 active site 930170011057 regulatory phosphorylation site [posttranslational modification]; other site 930170011058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930170011059 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 930170011060 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930170011061 active site turn [active] 930170011062 phosphorylation site [posttranslational modification] 930170011063 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930170011064 HPr interaction site; other site 930170011065 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930170011066 active site 930170011067 phosphorylation site [posttranslational modification] 930170011068 transcriptional antiterminator BglG; Provisional; Region: PRK09772 930170011069 CAT RNA binding domain; Region: CAT_RBD; smart01061 930170011070 PRD domain; Region: PRD; pfam00874 930170011071 PRD domain; Region: PRD; pfam00874 930170011072 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170011073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170011074 active site 930170011075 motif I; other site 930170011076 motif II; other site 930170011077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170011078 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930170011079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170011080 DNA-binding site [nucleotide binding]; DNA binding site 930170011081 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930170011082 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930170011083 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930170011084 active site 930170011085 trimer interface [polypeptide binding]; other site 930170011086 allosteric site; other site 930170011087 active site lid [active] 930170011088 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930170011089 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 930170011090 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930170011091 active site 930170011092 dimer interface [polypeptide binding]; other site 930170011093 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 930170011094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170011095 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 930170011096 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 930170011097 Domain of unknown function (DUF309); Region: DUF309; pfam03745 930170011098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170011099 Coenzyme A binding pocket [chemical binding]; other site 930170011100 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 930170011101 active site 930170011102 Predicted secreted protein [Function unknown]; Region: COG4086 930170011103 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 930170011104 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170011105 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 930170011106 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930170011107 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170011108 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 930170011109 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 930170011110 stage V sporulation protein AD; Validated; Region: PRK08304 930170011111 stage V sporulation protein AD; Provisional; Region: PRK12404 930170011112 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 930170011113 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 930170011114 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 930170011115 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 930170011116 Na2 binding site [ion binding]; other site 930170011117 putative substrate binding site 1 [chemical binding]; other site 930170011118 Na binding site 1 [ion binding]; other site 930170011119 putative substrate binding site 2 [chemical binding]; other site 930170011120 sporulation sigma factor SigF; Validated; Region: PRK05572 930170011121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170011122 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930170011123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170011124 DNA binding residues [nucleotide binding] 930170011125 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 930170011126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170011127 ATP binding site [chemical binding]; other site 930170011128 Mg2+ binding site [ion binding]; other site 930170011129 G-X-G motif; other site 930170011130 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 930170011131 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 930170011132 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170011133 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 930170011134 Predicted transcriptional regulators [Transcription]; Region: COG1725 930170011135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170011136 DNA-binding site [nucleotide binding]; DNA binding site 930170011137 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170011138 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170011139 Walker A/P-loop; other site 930170011140 ATP binding site [chemical binding]; other site 930170011141 Q-loop/lid; other site 930170011142 ABC transporter signature motif; other site 930170011143 Walker B; other site 930170011144 D-loop; other site 930170011145 H-loop/switch region; other site 930170011146 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170011147 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 930170011148 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170011149 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170011150 MarR family; Region: MarR; pfam01047 930170011151 MarR family; Region: MarR_2; cl17246 930170011152 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 930170011153 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930170011154 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 930170011155 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 930170011156 oligomer interface [polypeptide binding]; other site 930170011157 metal binding site [ion binding]; metal-binding site 930170011158 metal binding site [ion binding]; metal-binding site 930170011159 putative Cl binding site [ion binding]; other site 930170011160 aspartate ring; other site 930170011161 basic sphincter; other site 930170011162 hydrophobic gate; other site 930170011163 periplasmic entrance; other site 930170011164 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 930170011165 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930170011166 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930170011167 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 930170011168 purine nucleoside phosphorylase; Provisional; Region: PRK08202 930170011169 phosphopentomutase; Provisional; Region: PRK05362 930170011170 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 930170011171 YtkA-like; Region: YtkA; pfam13115 930170011172 YtkA-like; Region: YtkA; pfam13115 930170011173 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 930170011174 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930170011175 active site 930170011176 Int/Topo IB signature motif; other site 930170011177 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 930170011178 ferric uptake regulator; Provisional; Region: fur; PRK09462 930170011179 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930170011180 metal binding site 2 [ion binding]; metal-binding site 930170011181 putative DNA binding helix; other site 930170011182 metal binding site 1 [ion binding]; metal-binding site 930170011183 dimer interface [polypeptide binding]; other site 930170011184 structural Zn2+ binding site [ion binding]; other site 930170011185 stage II sporulation protein M; Region: spo_II_M; TIGR02831 930170011186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170011187 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170011188 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 930170011189 dimer interface [polypeptide binding]; other site 930170011190 ADP-ribose binding site [chemical binding]; other site 930170011191 active site 930170011192 nudix motif; other site 930170011193 metal binding site [ion binding]; metal-binding site 930170011194 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 930170011195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930170011196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930170011197 active site 930170011198 catalytic tetrad [active] 930170011199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930170011200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930170011201 active site 930170011202 catalytic tetrad [active] 930170011203 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 930170011204 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 930170011205 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930170011206 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 930170011207 putative active site [active] 930170011208 putative metal binding site [ion binding]; other site 930170011209 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930170011210 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 930170011211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170011212 Predicted permease [General function prediction only]; Region: COG2056 930170011213 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 930170011214 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 930170011215 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170011216 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170011217 DNA binding site [nucleotide binding] 930170011218 domain linker motif; other site 930170011219 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930170011220 dimerization interface [polypeptide binding]; other site 930170011221 ligand binding site [chemical binding]; other site 930170011222 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170011223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170011224 Coenzyme A binding pocket [chemical binding]; other site 930170011225 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930170011226 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 930170011227 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 930170011228 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 930170011229 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 930170011230 catalytic motif [active] 930170011231 Zn binding site [ion binding]; other site 930170011232 RibD C-terminal domain; Region: RibD_C; cl17279 930170011233 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 930170011234 Lumazine binding domain; Region: Lum_binding; pfam00677 930170011235 Lumazine binding domain; Region: Lum_binding; pfam00677 930170011236 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 930170011237 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 930170011238 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 930170011239 dimerization interface [polypeptide binding]; other site 930170011240 active site 930170011241 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 930170011242 homopentamer interface [polypeptide binding]; other site 930170011243 active site 930170011244 biotin synthase; Validated; Region: PRK06256 930170011245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170011246 FeS/SAM binding site; other site 930170011247 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 930170011248 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 930170011249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170011250 S-adenosylmethionine binding site [chemical binding]; other site 930170011251 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170011252 TAP-like protein; Region: Abhydrolase_4; pfam08386 930170011253 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 930170011254 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 930170011255 substrate-cofactor binding pocket; other site 930170011256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011257 catalytic residue [active] 930170011258 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 930170011259 AAA domain; Region: AAA_26; pfam13500 930170011260 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 930170011261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170011262 inhibitor-cofactor binding pocket; inhibition site 930170011263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011264 catalytic residue [active] 930170011265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 930170011266 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 930170011267 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 930170011268 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 930170011269 active site 930170011270 metal binding site [ion binding]; metal-binding site 930170011271 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930170011272 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 930170011273 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 930170011274 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 930170011275 active site 930170011276 catalytic triad [active] 930170011277 oxyanion hole [active] 930170011278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170011279 dimerization interface [polypeptide binding]; other site 930170011280 putative DNA binding site [nucleotide binding]; other site 930170011281 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170011282 putative Zn2+ binding site [ion binding]; other site 930170011283 ornithine carbamoyltransferase; Provisional; Region: PRK00779 930170011284 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930170011285 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930170011286 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 930170011287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170011288 inhibitor-cofactor binding pocket; inhibition site 930170011289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011290 catalytic residue [active] 930170011291 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 930170011292 nucleotide binding site [chemical binding]; other site 930170011293 N-acetyl-L-glutamate binding site [chemical binding]; other site 930170011294 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 930170011295 heterotetramer interface [polypeptide binding]; other site 930170011296 active site pocket [active] 930170011297 cleavage site 930170011298 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 930170011299 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930170011300 YqzH-like protein; Region: YqzH; pfam14164 930170011301 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 930170011302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170011303 NAD(P) binding site [chemical binding]; other site 930170011304 active site 930170011305 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170011306 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 930170011307 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 930170011308 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 930170011309 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 930170011310 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 930170011311 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 930170011312 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 930170011313 putative L-serine binding site [chemical binding]; other site 930170011314 ribonuclease Z; Region: RNase_Z; TIGR02651 930170011315 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 930170011316 magnesium-transporting ATPase; Provisional; Region: PRK15122 930170011317 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 930170011318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930170011319 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930170011320 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930170011321 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930170011322 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 930170011323 MgtC family; Region: MgtC; pfam02308 930170011324 DNA polymerase IV; Validated; Region: PRK01810 930170011325 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 930170011326 active site 930170011327 DNA binding site [nucleotide binding] 930170011328 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 930170011329 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 930170011330 peptidase T-like protein; Region: PepT-like; TIGR01883 930170011331 metal binding site [ion binding]; metal-binding site 930170011332 putative dimer interface [polypeptide binding]; other site 930170011333 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170011334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170011335 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 930170011336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 930170011337 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 930170011338 Predicted membrane protein [Function unknown]; Region: COG4129 930170011339 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 930170011340 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 930170011341 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930170011342 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930170011343 Walker A/P-loop; other site 930170011344 ATP binding site [chemical binding]; other site 930170011345 Q-loop/lid; other site 930170011346 ABC transporter signature motif; other site 930170011347 Walker B; other site 930170011348 D-loop; other site 930170011349 H-loop/switch region; other site 930170011350 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930170011351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170011352 dimer interface [polypeptide binding]; other site 930170011353 conserved gate region; other site 930170011354 putative PBP binding loops; other site 930170011355 ABC-ATPase subunit interface; other site 930170011356 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930170011357 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930170011358 substrate binding pocket [chemical binding]; other site 930170011359 membrane-bound complex binding site; other site 930170011360 hinge residues; other site 930170011361 Disulphide isomerase; Region: Disulph_isomer; pfam06491 930170011362 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 930170011363 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 930170011364 nudix motif; other site 930170011365 Predicted membrane protein [Function unknown]; Region: COG2323 930170011366 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 930170011367 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930170011368 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930170011369 E3 interaction surface; other site 930170011370 lipoyl attachment site [posttranslational modification]; other site 930170011371 e3 binding domain; Region: E3_binding; pfam02817 930170011372 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930170011373 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930170011374 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930170011375 alpha subunit interface [polypeptide binding]; other site 930170011376 TPP binding site [chemical binding]; other site 930170011377 heterodimer interface [polypeptide binding]; other site 930170011378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170011379 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 930170011380 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930170011381 tetramer interface [polypeptide binding]; other site 930170011382 TPP-binding site [chemical binding]; other site 930170011383 heterodimer interface [polypeptide binding]; other site 930170011384 phosphorylation loop region [posttranslational modification] 930170011385 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 930170011386 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 930170011387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170011388 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930170011389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930170011390 nucleotide binding site [chemical binding]; other site 930170011391 Acetokinase family; Region: Acetate_kinase; cl17229 930170011392 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 930170011393 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 930170011394 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 930170011395 NAD binding site [chemical binding]; other site 930170011396 Phe binding site; other site 930170011397 phosphate butyryltransferase; Validated; Region: PRK07742 930170011398 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 930170011399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170011400 putative active site [active] 930170011401 heme pocket [chemical binding]; other site 930170011402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170011403 putative active site [active] 930170011404 heme pocket [chemical binding]; other site 930170011405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170011406 Walker A motif; other site 930170011407 ATP binding site [chemical binding]; other site 930170011408 Walker B motif; other site 930170011409 arginine finger; other site 930170011410 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930170011411 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 930170011412 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930170011413 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 930170011414 active site 930170011415 catalytic site [active] 930170011416 metal binding site [ion binding]; metal-binding site 930170011417 dimer interface [polypeptide binding]; other site 930170011418 YycC-like protein; Region: YycC; pfam14174 930170011419 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 930170011420 DEK C terminal domain; Region: DEK_C; pfam08766 930170011421 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930170011422 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 930170011423 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 930170011424 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 930170011425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170011426 active site 930170011427 phosphorylation site [posttranslational modification] 930170011428 intermolecular recognition site; other site 930170011429 dimerization interface [polypeptide binding]; other site 930170011430 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 930170011431 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 930170011432 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 930170011433 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 930170011434 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 930170011435 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930170011436 Walker A/P-loop; other site 930170011437 ATP binding site [chemical binding]; other site 930170011438 Q-loop/lid; other site 930170011439 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930170011440 ABC transporter signature motif; other site 930170011441 Walker B; other site 930170011442 D-loop; other site 930170011443 H-loop/switch region; other site 930170011444 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 930170011445 arginine repressor; Provisional; Region: PRK04280 930170011446 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 930170011447 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 930170011448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170011449 RNA binding surface [nucleotide binding]; other site 930170011450 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 930170011451 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 930170011452 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 930170011453 TPP-binding site; other site 930170011454 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930170011455 PYR/PP interface [polypeptide binding]; other site 930170011456 dimer interface [polypeptide binding]; other site 930170011457 TPP binding site [chemical binding]; other site 930170011458 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930170011459 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930170011460 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930170011461 substrate binding pocket [chemical binding]; other site 930170011462 chain length determination region; other site 930170011463 substrate-Mg2+ binding site; other site 930170011464 catalytic residues [active] 930170011465 aspartate-rich region 1; other site 930170011466 active site lid residues [active] 930170011467 aspartate-rich region 2; other site 930170011468 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 930170011469 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 930170011470 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 930170011471 generic binding surface II; other site 930170011472 generic binding surface I; other site 930170011473 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 930170011474 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 930170011475 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 930170011476 homodimer interface [polypeptide binding]; other site 930170011477 NADP binding site [chemical binding]; other site 930170011478 substrate binding site [chemical binding]; other site 930170011479 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 930170011480 putative RNA binding site [nucleotide binding]; other site 930170011481 Asp23 family; Region: Asp23; pfam03780 930170011482 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 930170011483 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930170011484 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930170011485 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930170011486 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 930170011487 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930170011488 carboxyltransferase (CT) interaction site; other site 930170011489 biotinylation site [posttranslational modification]; other site 930170011490 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 930170011491 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 930170011492 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 930170011493 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 930170011494 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 930170011495 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 930170011496 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 930170011497 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 930170011498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170011499 Walker A motif; other site 930170011500 ATP binding site [chemical binding]; other site 930170011501 Walker B motif; other site 930170011502 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 930170011503 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170011504 elongation factor P; Validated; Region: PRK00529 930170011505 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 930170011506 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 930170011507 RNA binding site [nucleotide binding]; other site 930170011508 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 930170011509 RNA binding site [nucleotide binding]; other site 930170011510 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930170011511 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930170011512 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930170011513 active site 930170011514 Dehydroquinase class II; Region: DHquinase_II; pfam01220 930170011515 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 930170011516 trimer interface [polypeptide binding]; other site 930170011517 active site 930170011518 dimer interface [polypeptide binding]; other site 930170011519 Conserved membrane protein YqhR; Region: YqhR; pfam11085 930170011520 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 930170011521 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 930170011522 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930170011523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170011524 motif II; other site 930170011525 manganese transport transcriptional regulator; Provisional; Region: PRK03902 930170011526 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 930170011527 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 930170011528 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 930170011529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170011530 FeS/SAM binding site; other site 930170011531 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930170011532 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930170011533 active site residue [active] 930170011534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170011535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170011536 DNA binding site [nucleotide binding] 930170011537 domain linker motif; other site 930170011538 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930170011539 putative dimerization interface [polypeptide binding]; other site 930170011540 putative ligand binding site [chemical binding]; other site 930170011541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170011542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170011543 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170011544 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930170011545 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 930170011546 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930170011547 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930170011548 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930170011549 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930170011550 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170011551 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170011552 Walker A/P-loop; other site 930170011553 ATP binding site [chemical binding]; other site 930170011554 Q-loop/lid; other site 930170011555 ABC transporter signature motif; other site 930170011556 Walker B; other site 930170011557 D-loop; other site 930170011558 H-loop/switch region; other site 930170011559 Predicted transcriptional regulators [Transcription]; Region: COG1725 930170011560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170011561 DNA-binding site [nucleotide binding]; DNA binding site 930170011562 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 930170011563 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930170011564 tetramer interface [polypeptide binding]; other site 930170011565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011566 catalytic residue [active] 930170011567 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 930170011568 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930170011569 tetramer interface [polypeptide binding]; other site 930170011570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011571 catalytic residue [active] 930170011572 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 930170011573 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 930170011574 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930170011575 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930170011576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170011577 ATP binding site [chemical binding]; other site 930170011578 putative Mg++ binding site [ion binding]; other site 930170011579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170011580 nucleotide binding region [chemical binding]; other site 930170011581 ATP-binding site [chemical binding]; other site 930170011582 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 930170011583 YqzE-like protein; Region: YqzE; pfam14038 930170011584 shikimate kinase; Reviewed; Region: aroK; PRK00131 930170011585 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 930170011586 ADP binding site [chemical binding]; other site 930170011587 magnesium binding site [ion binding]; other site 930170011588 putative shikimate binding site; other site 930170011589 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 930170011590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170011591 putative DNA binding site [nucleotide binding]; other site 930170011592 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 930170011593 putative Zn2+ binding site [ion binding]; other site 930170011594 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 930170011595 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 930170011596 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930170011597 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 930170011598 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170011599 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 930170011600 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 930170011601 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 930170011602 active site 930170011603 homodimer interface [polypeptide binding]; other site 930170011604 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 930170011605 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 930170011606 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 930170011607 substrate binding pocket [chemical binding]; other site 930170011608 dimer interface [polypeptide binding]; other site 930170011609 inhibitor binding site; inhibition site 930170011610 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 930170011611 B12 binding site [chemical binding]; other site 930170011612 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 930170011613 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 930170011614 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 930170011615 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 930170011616 FAD binding site [chemical binding]; other site 930170011617 cystathionine gamma-synthase; Reviewed; Region: PRK08247 930170011618 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930170011619 homodimer interface [polypeptide binding]; other site 930170011620 substrate-cofactor binding pocket; other site 930170011621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011622 catalytic residue [active] 930170011623 cystathionine beta-lyase; Provisional; Region: PRK08064 930170011624 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930170011625 homodimer interface [polypeptide binding]; other site 930170011626 substrate-cofactor binding pocket; other site 930170011627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011628 catalytic residue [active] 930170011629 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 930170011630 Isochorismatase family; Region: Isochorismatase; pfam00857 930170011631 catalytic triad [active] 930170011632 conserved cis-peptide bond; other site 930170011633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170011634 dimerization interface [polypeptide binding]; other site 930170011635 putative DNA binding site [nucleotide binding]; other site 930170011636 putative Zn2+ binding site [ion binding]; other site 930170011637 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 930170011638 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 930170011639 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 930170011640 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 930170011641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930170011642 nucleotide binding site [chemical binding]; other site 930170011643 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 930170011644 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 930170011645 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 930170011646 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 930170011647 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 930170011648 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 930170011649 active site 930170011650 Substrate binding site; other site 930170011651 Mg++ binding site; other site 930170011652 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930170011653 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 930170011654 active site 930170011655 metal binding site [ion binding]; metal-binding site 930170011656 substrate binding site [chemical binding]; other site 930170011657 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 930170011658 PhoU domain; Region: PhoU; pfam01895 930170011659 PhoU domain; Region: PhoU; pfam01895 930170011660 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 930170011661 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 930170011662 Walker A/P-loop; other site 930170011663 ATP binding site [chemical binding]; other site 930170011664 Q-loop/lid; other site 930170011665 ABC transporter signature motif; other site 930170011666 Walker B; other site 930170011667 D-loop; other site 930170011668 H-loop/switch region; other site 930170011669 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 930170011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170011671 dimer interface [polypeptide binding]; other site 930170011672 conserved gate region; other site 930170011673 putative PBP binding loops; other site 930170011674 ABC-ATPase subunit interface; other site 930170011675 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 930170011676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170011677 dimer interface [polypeptide binding]; other site 930170011678 conserved gate region; other site 930170011679 putative PBP binding loops; other site 930170011680 ABC-ATPase subunit interface; other site 930170011681 PBP superfamily domain; Region: PBP_like_2; cl17296 930170011682 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170011683 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170011684 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170011685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170011686 putative substrate translocation pore; other site 930170011687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170011688 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 930170011689 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 930170011690 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 930170011691 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 930170011692 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 930170011693 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930170011694 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930170011695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930170011696 metal binding site 2 [ion binding]; metal-binding site 930170011697 putative DNA binding helix; other site 930170011698 metal binding site 1 [ion binding]; metal-binding site 930170011699 dimer interface [polypeptide binding]; other site 930170011700 structural Zn2+ binding site [ion binding]; other site 930170011701 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930170011702 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170011703 ABC-ATPase subunit interface; other site 930170011704 dimer interface [polypeptide binding]; other site 930170011705 putative PBP binding regions; other site 930170011706 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930170011707 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930170011708 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170011709 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170011710 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170011711 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 930170011712 endonuclease IV; Provisional; Region: PRK01060 930170011713 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 930170011714 AP (apurinic/apyrimidinic) site pocket; other site 930170011715 DNA interaction; other site 930170011716 Metal-binding active site; metal-binding site 930170011717 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930170011718 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930170011719 ATP binding site [chemical binding]; other site 930170011720 Mg++ binding site [ion binding]; other site 930170011721 motif III; other site 930170011722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170011723 nucleotide binding region [chemical binding]; other site 930170011724 ATP-binding site [chemical binding]; other site 930170011725 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 930170011726 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 930170011727 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930170011728 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930170011729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 930170011730 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930170011731 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930170011732 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 930170011733 Family of unknown function (DUF633); Region: DUF633; pfam04816 930170011734 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 930170011735 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 930170011736 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 930170011737 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 930170011738 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 930170011739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170011740 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930170011741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170011742 DNA binding residues [nucleotide binding] 930170011743 DNA primase; Validated; Region: dnaG; PRK05667 930170011744 CHC2 zinc finger; Region: zf-CHC2; pfam01807 930170011745 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 930170011746 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 930170011747 active site 930170011748 metal binding site [ion binding]; metal-binding site 930170011749 interdomain interaction site; other site 930170011750 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 930170011751 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 930170011752 PEP synthetase regulatory protein; Provisional; Region: PRK05339 930170011753 HTH domain; Region: HTH_11; pfam08279 930170011754 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 930170011755 FOG: CBS domain [General function prediction only]; Region: COG0517 930170011756 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 930170011757 Recombination protein O N terminal; Region: RecO_N; pfam11967 930170011758 Recombination protein O C terminal; Region: RecO_C; pfam02565 930170011759 YqzL-like protein; Region: YqzL; pfam14006 930170011760 GTPase Era; Reviewed; Region: era; PRK00089 930170011761 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 930170011762 G1 box; other site 930170011763 GTP/Mg2+ binding site [chemical binding]; other site 930170011764 Switch I region; other site 930170011765 G2 box; other site 930170011766 Switch II region; other site 930170011767 G3 box; other site 930170011768 G4 box; other site 930170011769 G5 box; other site 930170011770 KH domain; Region: KH_2; pfam07650 930170011771 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 930170011772 active site 930170011773 catalytic motif [active] 930170011774 Zn binding site [ion binding]; other site 930170011775 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 930170011776 metal-binding heat shock protein; Provisional; Region: PRK00016 930170011777 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 930170011778 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 930170011779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170011780 Zn2+ binding site [ion binding]; other site 930170011781 Mg2+ binding site [ion binding]; other site 930170011782 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 930170011783 PhoH-like protein; Region: PhoH; pfam02562 930170011784 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 930170011785 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 930170011786 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 930170011787 Yqey-like protein; Region: YqeY; pfam09424 930170011788 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 930170011789 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 930170011790 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 930170011791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170011792 FeS/SAM binding site; other site 930170011793 TRAM domain; Region: TRAM; cl01282 930170011794 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 930170011795 RNA methyltransferase, RsmE family; Region: TIGR00046 930170011796 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 930170011797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170011798 S-adenosylmethionine binding site [chemical binding]; other site 930170011799 chaperone protein DnaJ; Provisional; Region: PRK14280 930170011800 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930170011801 HSP70 interaction site [polypeptide binding]; other site 930170011802 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 930170011803 substrate binding site [polypeptide binding]; other site 930170011804 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 930170011805 Zn binding sites [ion binding]; other site 930170011806 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 930170011807 dimer interface [polypeptide binding]; other site 930170011808 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 930170011809 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 930170011810 nucleotide binding site [chemical binding]; other site 930170011811 NEF interaction site [polypeptide binding]; other site 930170011812 SBD interface [polypeptide binding]; other site 930170011813 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 930170011814 GrpE; Region: GrpE; pfam01025 930170011815 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 930170011816 dimer interface [polypeptide binding]; other site 930170011817 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 930170011818 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 930170011819 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 930170011820 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 930170011821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170011822 FeS/SAM binding site; other site 930170011823 HemN C-terminal domain; Region: HemN_C; pfam06969 930170011824 Predicted transcriptional regulators [Transcription]; Region: COG1733 930170011825 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930170011826 GTP-binding protein LepA; Provisional; Region: PRK05433 930170011827 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 930170011828 G1 box; other site 930170011829 putative GEF interaction site [polypeptide binding]; other site 930170011830 GTP/Mg2+ binding site [chemical binding]; other site 930170011831 Switch I region; other site 930170011832 G2 box; other site 930170011833 G3 box; other site 930170011834 Switch II region; other site 930170011835 G4 box; other site 930170011836 G5 box; other site 930170011837 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 930170011838 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 930170011839 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 930170011840 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 930170011841 germination protease; Provisional; Region: PRK02858 930170011842 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 930170011843 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 930170011844 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 930170011845 YqzM-like protein; Region: YqzM; pfam14141 930170011846 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 930170011847 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 930170011848 Competence protein; Region: Competence; pfam03772 930170011849 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170011850 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 930170011851 catalytic motif [active] 930170011852 Zn binding site [ion binding]; other site 930170011853 SLBB domain; Region: SLBB; pfam10531 930170011854 comEA protein; Region: comE; TIGR01259 930170011855 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 930170011856 late competence protein ComER; Validated; Region: PRK07680 930170011857 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 930170011858 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 930170011859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170011860 S-adenosylmethionine binding site [chemical binding]; other site 930170011861 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 930170011862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170011863 Zn2+ binding site [ion binding]; other site 930170011864 Mg2+ binding site [ion binding]; other site 930170011865 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 930170011866 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 930170011867 active site 930170011868 (T/H)XGH motif; other site 930170011869 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 930170011870 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 930170011871 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930170011872 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930170011873 shikimate binding site; other site 930170011874 NAD(P) binding site [chemical binding]; other site 930170011875 GTPase YqeH; Provisional; Region: PRK13796 930170011876 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 930170011877 GTP/Mg2+ binding site [chemical binding]; other site 930170011878 G4 box; other site 930170011879 G5 box; other site 930170011880 G1 box; other site 930170011881 Switch I region; other site 930170011882 G2 box; other site 930170011883 G3 box; other site 930170011884 Switch II region; other site 930170011885 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 930170011886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170011887 active site 930170011888 motif I; other site 930170011889 motif II; other site 930170011890 Sporulation inhibitor A; Region: Sda; pfam08970 930170011891 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 930170011892 sporulation sigma factor SigK; Reviewed; Region: PRK05803 930170011893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170011894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170011895 DNA binding residues [nucleotide binding] 930170011896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 930170011897 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170011898 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930170011899 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 930170011900 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930170011901 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930170011902 synthetase active site [active] 930170011903 NTP binding site [chemical binding]; other site 930170011904 metal binding site [ion binding]; metal-binding site 930170011905 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 930170011906 dimer interface [polypeptide binding]; other site 930170011907 Alkaline phosphatase homologues; Region: alkPPc; smart00098 930170011908 active site 930170011909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170011910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930170011911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170011912 Coenzyme A binding pocket [chemical binding]; other site 930170011913 PGAP1-like protein; Region: PGAP1; pfam07819 930170011914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170011915 DoxX; Region: DoxX; cl17842 930170011916 CHAT domain; Region: CHAT; cl17868 930170011917 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 930170011918 catalytic core [active] 930170011919 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 930170011920 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 930170011921 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 930170011922 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 930170011923 putative active site [active] 930170011924 catalytic triad [active] 930170011925 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 930170011926 putative integrin binding motif; other site 930170011927 PA/protease domain interface [polypeptide binding]; other site 930170011928 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 930170011929 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 930170011930 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 930170011931 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 930170011932 cofactor binding site; other site 930170011933 metal binding site [ion binding]; metal-binding site 930170011934 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 930170011935 aromatic arch; other site 930170011936 DCoH dimer interaction site [polypeptide binding]; other site 930170011937 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 930170011938 DCoH tetramer interaction site [polypeptide binding]; other site 930170011939 substrate binding site [chemical binding]; other site 930170011940 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 930170011941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 930170011942 putative metal binding site [ion binding]; other site 930170011943 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930170011944 active site 930170011945 metal binding site [ion binding]; metal-binding site 930170011946 Predicted membrane protein [Function unknown]; Region: COG2259 930170011947 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930170011948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170011949 non-specific DNA binding site [nucleotide binding]; other site 930170011950 salt bridge; other site 930170011951 sequence-specific DNA binding site [nucleotide binding]; other site 930170011952 Cupin domain; Region: Cupin_2; pfam07883 930170011953 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 930170011954 active site 2 [active] 930170011955 active site 1 [active] 930170011956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170011957 Coenzyme A binding pocket [chemical binding]; other site 930170011958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170011959 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170011960 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930170011961 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930170011962 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170011963 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930170011964 Walker A/P-loop; other site 930170011965 ATP binding site [chemical binding]; other site 930170011966 Q-loop/lid; other site 930170011967 ABC transporter signature motif; other site 930170011968 Walker B; other site 930170011969 D-loop; other site 930170011970 H-loop/switch region; other site 930170011971 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930170011972 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170011973 ABC-ATPase subunit interface; other site 930170011974 dimer interface [polypeptide binding]; other site 930170011975 putative PBP binding regions; other site 930170011976 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170011977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930170011978 intersubunit interface [polypeptide binding]; other site 930170011979 YrhC-like protein; Region: YrhC; pfam14143 930170011980 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 930170011981 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 930170011982 putative catalytic cysteine [active] 930170011983 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 930170011984 putative active site [active] 930170011985 metal binding site [ion binding]; metal-binding site 930170011986 cystathionine beta-lyase; Provisional; Region: PRK07671 930170011987 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930170011988 homodimer interface [polypeptide binding]; other site 930170011989 substrate-cofactor binding pocket; other site 930170011990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011991 catalytic residue [active] 930170011992 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930170011993 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930170011994 dimer interface [polypeptide binding]; other site 930170011995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170011996 catalytic residue [active] 930170011997 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 930170011998 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 930170011999 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930170012000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170012001 S-adenosylmethionine binding site [chemical binding]; other site 930170012002 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 930170012003 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 930170012004 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930170012005 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930170012006 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170012007 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 930170012008 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 930170012009 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 930170012010 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 930170012011 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 930170012012 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 930170012013 ATP-binding site [chemical binding]; other site 930170012014 Sugar specificity; other site 930170012015 Pyrimidine base specificity; other site 930170012016 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930170012017 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 930170012018 Peptidase family U32; Region: Peptidase_U32; pfam01136 930170012019 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930170012020 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 930170012021 Peptidase family U32; Region: Peptidase_U32; pfam01136 930170012022 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 930170012023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170012024 S-adenosylmethionine binding site [chemical binding]; other site 930170012025 YceG-like family; Region: YceG; pfam02618 930170012026 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 930170012027 dimerization interface [polypeptide binding]; other site 930170012028 hypothetical protein; Provisional; Region: PRK13678 930170012029 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 930170012030 hypothetical protein; Provisional; Region: PRK05473 930170012031 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 930170012032 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 930170012033 motif 1; other site 930170012034 active site 930170012035 motif 2; other site 930170012036 motif 3; other site 930170012037 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930170012038 DHHA1 domain; Region: DHHA1; pfam02272 930170012039 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930170012040 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930170012041 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 930170012042 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 930170012043 AAA domain; Region: AAA_30; pfam13604 930170012044 Family description; Region: UvrD_C_2; pfam13538 930170012045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170012046 TPR motif; other site 930170012047 TPR repeat; Region: TPR_11; pfam13414 930170012048 binding surface 930170012049 TPR repeat; Region: TPR_11; pfam13414 930170012050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170012051 binding surface 930170012052 TPR motif; other site 930170012053 TPR repeat; Region: TPR_11; pfam13414 930170012054 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 930170012055 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 930170012056 Ligand Binding Site [chemical binding]; other site 930170012057 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930170012058 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930170012059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170012060 catalytic residue [active] 930170012061 Predicted transcriptional regulator [Transcription]; Region: COG1959 930170012062 Transcriptional regulator; Region: Rrf2; pfam02082 930170012063 recombination factor protein RarA; Reviewed; Region: PRK13342 930170012064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170012065 Walker A motif; other site 930170012066 ATP binding site [chemical binding]; other site 930170012067 Walker B motif; other site 930170012068 arginine finger; other site 930170012069 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 930170012070 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 930170012071 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 930170012072 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 930170012073 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 930170012074 putative ATP binding site [chemical binding]; other site 930170012075 putative substrate interface [chemical binding]; other site 930170012076 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 930170012077 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 930170012078 dimer interface [polypeptide binding]; other site 930170012079 anticodon binding site; other site 930170012080 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930170012081 homodimer interface [polypeptide binding]; other site 930170012082 motif 1; other site 930170012083 active site 930170012084 motif 2; other site 930170012085 GAD domain; Region: GAD; pfam02938 930170012086 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930170012087 motif 3; other site 930170012088 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 930170012089 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930170012090 dimer interface [polypeptide binding]; other site 930170012091 motif 1; other site 930170012092 active site 930170012093 motif 2; other site 930170012094 motif 3; other site 930170012095 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 930170012096 anticodon binding site; other site 930170012097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170012098 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 930170012099 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 930170012100 putative active site [active] 930170012101 dimerization interface [polypeptide binding]; other site 930170012102 putative tRNAtyr binding site [nucleotide binding]; other site 930170012103 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930170012104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170012105 Zn2+ binding site [ion binding]; other site 930170012106 Mg2+ binding site [ion binding]; other site 930170012107 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930170012108 synthetase active site [active] 930170012109 NTP binding site [chemical binding]; other site 930170012110 metal binding site [ion binding]; metal-binding site 930170012111 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 930170012112 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 930170012113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170012114 active site 930170012115 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 930170012116 DHH family; Region: DHH; pfam01368 930170012117 DHHA1 domain; Region: DHHA1; pfam02272 930170012118 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 930170012119 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930170012120 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 930170012121 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 930170012122 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 930170012123 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 930170012124 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 930170012125 Protein export membrane protein; Region: SecD_SecF; pfam02355 930170012126 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 930170012127 stage V sporulation protein B; Region: spore_V_B; TIGR02900 930170012128 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930170012129 Predicted membrane protein [Function unknown]; Region: COG2323 930170012130 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 930170012131 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 930170012132 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 930170012133 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 930170012134 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 930170012135 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 930170012136 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 930170012137 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 930170012138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170012139 Walker A motif; other site 930170012140 ATP binding site [chemical binding]; other site 930170012141 Walker B motif; other site 930170012142 arginine finger; other site 930170012143 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 930170012144 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 930170012145 RuvA N terminal domain; Region: RuvA_N; pfam01330 930170012146 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 930170012147 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170012148 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 930170012149 putative ligand binding residues [chemical binding]; other site 930170012150 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 930170012151 BofC C-terminal domain; Region: BofC_C; pfam08955 930170012152 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170012153 EamA-like transporter family; Region: EamA; pfam00892 930170012154 EamA-like transporter family; Region: EamA; pfam00892 930170012155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170012156 dimerization interface [polypeptide binding]; other site 930170012157 putative DNA binding site [nucleotide binding]; other site 930170012158 putative Zn2+ binding site [ion binding]; other site 930170012159 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 930170012160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170012161 quinolinate synthetase; Provisional; Region: PRK09375 930170012162 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 930170012163 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 930170012164 dimerization interface [polypeptide binding]; other site 930170012165 active site 930170012166 L-aspartate oxidase; Provisional; Region: PRK08071 930170012167 L-aspartate oxidase; Provisional; Region: PRK06175 930170012168 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 930170012169 cysteine desulfurase; Provisional; Region: PRK02948 930170012170 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930170012171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170012172 catalytic residue [active] 930170012173 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 930170012174 HTH domain; Region: HTH_11; pfam08279 930170012175 3H domain; Region: 3H; pfam02829 930170012176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 930170012177 MOSC domain; Region: MOSC; pfam03473 930170012178 3-alpha domain; Region: 3-alpha; pfam03475 930170012179 prephenate dehydratase; Provisional; Region: PRK11898 930170012180 Prephenate dehydratase; Region: PDT; pfam00800 930170012181 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 930170012182 putative L-Phe binding site [chemical binding]; other site 930170012183 FtsX-like permease family; Region: FtsX; pfam02687 930170012184 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170012185 FtsX-like permease family; Region: FtsX; pfam02687 930170012186 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170012187 FtsX-like permease family; Region: FtsX; pfam02687 930170012188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170012189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170012190 Walker A/P-loop; other site 930170012191 ATP binding site [chemical binding]; other site 930170012192 Q-loop/lid; other site 930170012193 ABC transporter signature motif; other site 930170012194 Walker B; other site 930170012195 D-loop; other site 930170012196 H-loop/switch region; other site 930170012197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170012198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 930170012199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170012200 ATP binding site [chemical binding]; other site 930170012201 Mg2+ binding site [ion binding]; other site 930170012202 G-X-G motif; other site 930170012203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170012204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170012205 active site 930170012206 phosphorylation site [posttranslational modification] 930170012207 intermolecular recognition site; other site 930170012208 dimerization interface [polypeptide binding]; other site 930170012209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170012210 DNA binding site [nucleotide binding] 930170012211 GTPase CgtA; Reviewed; Region: obgE; PRK12297 930170012212 GTP1/OBG; Region: GTP1_OBG; pfam01018 930170012213 Obg GTPase; Region: Obg; cd01898 930170012214 G1 box; other site 930170012215 GTP/Mg2+ binding site [chemical binding]; other site 930170012216 Switch I region; other site 930170012217 G2 box; other site 930170012218 G3 box; other site 930170012219 Switch II region; other site 930170012220 G4 box; other site 930170012221 G5 box; other site 930170012222 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 930170012223 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 930170012224 hypothetical protein; Provisional; Region: PRK14553 930170012225 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 930170012226 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 930170012227 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 930170012228 homodimer interface [polypeptide binding]; other site 930170012229 oligonucleotide binding site [chemical binding]; other site 930170012230 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 930170012231 Peptidase family M50; Region: Peptidase_M50; pfam02163 930170012232 active site 930170012233 putative substrate binding region [chemical binding]; other site 930170012234 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170012235 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170012236 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 930170012237 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 930170012238 Switch I; other site 930170012239 Switch II; other site 930170012240 septum formation inhibitor; Reviewed; Region: minC; PRK00513 930170012241 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 930170012242 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 930170012243 rod shape-determining protein MreC; Provisional; Region: PRK13922 930170012244 rod shape-determining protein MreC; Region: MreC; pfam04085 930170012245 rod shape-determining protein MreB; Provisional; Region: PRK13927 930170012246 MreB and similar proteins; Region: MreB_like; cd10225 930170012247 nucleotide binding site [chemical binding]; other site 930170012248 Mg binding site [ion binding]; other site 930170012249 putative protofilament interaction site [polypeptide binding]; other site 930170012250 RodZ interaction site [polypeptide binding]; other site 930170012251 hypothetical protein; Reviewed; Region: PRK00024 930170012252 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 930170012253 MPN+ (JAMM) motif; other site 930170012254 Zinc-binding site [ion binding]; other site 930170012255 Maf-like protein; Region: Maf; pfam02545 930170012256 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 930170012257 active site 930170012258 dimer interface [polypeptide binding]; other site 930170012259 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 930170012260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930170012261 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930170012262 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 930170012263 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930170012264 active site 930170012265 HIGH motif; other site 930170012266 nucleotide binding site [chemical binding]; other site 930170012267 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930170012268 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 930170012269 active site 930170012270 KMSKS motif; other site 930170012271 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 930170012272 tRNA binding surface [nucleotide binding]; other site 930170012273 anticodon binding site; other site 930170012274 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 930170012275 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 930170012276 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 930170012277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930170012278 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 930170012279 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930170012280 inhibitor-cofactor binding pocket; inhibition site 930170012281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170012282 catalytic residue [active] 930170012283 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 930170012284 dimer interface [polypeptide binding]; other site 930170012285 active site 930170012286 Schiff base residues; other site 930170012287 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 930170012288 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930170012289 active site 930170012290 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 930170012291 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 930170012292 domain interfaces; other site 930170012293 active site 930170012294 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 930170012295 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 930170012296 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 930170012297 tRNA; other site 930170012298 putative tRNA binding site [nucleotide binding]; other site 930170012299 putative NADP binding site [chemical binding]; other site 930170012300 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 930170012301 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930170012302 MarR family; Region: MarR; pfam01047 930170012303 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930170012304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930170012305 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930170012306 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 930170012307 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 930170012308 G1 box; other site 930170012309 GTP/Mg2+ binding site [chemical binding]; other site 930170012310 Switch I region; other site 930170012311 G2 box; other site 930170012312 G3 box; other site 930170012313 Switch II region; other site 930170012314 G4 box; other site 930170012315 G5 box; other site 930170012316 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 930170012317 Found in ATP-dependent protease La (LON); Region: LON; smart00464 930170012318 Found in ATP-dependent protease La (LON); Region: LON; smart00464 930170012319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170012320 Walker A motif; other site 930170012321 ATP binding site [chemical binding]; other site 930170012322 Walker B motif; other site 930170012323 arginine finger; other site 930170012324 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 930170012325 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 930170012326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170012327 Walker A motif; other site 930170012328 ATP binding site [chemical binding]; other site 930170012329 Walker B motif; other site 930170012330 arginine finger; other site 930170012331 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 930170012332 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 930170012333 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 930170012334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170012335 Walker A motif; other site 930170012336 ATP binding site [chemical binding]; other site 930170012337 Walker B motif; other site 930170012338 arginine finger; other site 930170012339 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930170012340 trigger factor; Provisional; Region: tig; PRK01490 930170012341 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 930170012342 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 930170012343 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 930170012344 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 930170012345 active site 930170012346 metal binding site [ion binding]; metal-binding site 930170012347 homotetramer interface [polypeptide binding]; other site 930170012348 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 930170012349 active site 930170012350 dimerization interface [polypeptide binding]; other site 930170012351 ribonuclease PH; Reviewed; Region: rph; PRK00173 930170012352 Ribonuclease PH; Region: RNase_PH_bact; cd11362 930170012353 hexamer interface [polypeptide binding]; other site 930170012354 active site 930170012355 Sporulation and spore germination; Region: Germane; pfam10646 930170012356 Spore germination protein [General function prediction only]; Region: COG5401 930170012357 Sporulation and spore germination; Region: Germane; pfam10646 930170012358 glutamate racemase; Provisional; Region: PRK00865 930170012359 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930170012360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 930170012361 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 930170012362 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 930170012363 potential catalytic triad [active] 930170012364 conserved cys residue [active] 930170012365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170012366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170012367 Probable transposase; Region: OrfB_IS605; pfam01385 930170012368 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170012369 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170012370 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 930170012371 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 930170012372 potential catalytic triad [active] 930170012373 conserved cys residue [active] 930170012374 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170012375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170012376 DNA binding residues [nucleotide binding] 930170012377 dimerization interface [polypeptide binding]; other site 930170012378 putative uracil/xanthine transporter; Provisional; Region: PRK11412 930170012379 putative deaminase; Validated; Region: PRK06846 930170012380 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 930170012381 active site 930170012382 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 930170012383 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930170012384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170012385 non-specific DNA binding site [nucleotide binding]; other site 930170012386 salt bridge; other site 930170012387 sequence-specific DNA binding site [nucleotide binding]; other site 930170012388 Cupin domain; Region: Cupin_2; pfam07883 930170012389 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 930170012390 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 930170012391 amphipathic channel; other site 930170012392 Asn-Pro-Ala signature motifs; other site 930170012393 Predicted transcriptional regulator [Transcription]; Region: COG1959 930170012394 Transcriptional regulator; Region: Rrf2; pfam02082 930170012395 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 930170012396 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 930170012397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170012398 Walker A/P-loop; other site 930170012399 ATP binding site [chemical binding]; other site 930170012400 Q-loop/lid; other site 930170012401 ABC transporter signature motif; other site 930170012402 Walker B; other site 930170012403 D-loop; other site 930170012404 H-loop/switch region; other site 930170012405 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 930170012406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170012407 active site 930170012408 motif I; other site 930170012409 motif II; other site 930170012410 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 930170012411 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 930170012412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 930170012413 ligand binding site [chemical binding]; other site 930170012414 flagellar motor protein MotA; Validated; Region: PRK08124 930170012415 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 930170012416 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 930170012417 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930170012418 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930170012419 active site 930170012420 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 930170012421 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 930170012422 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 930170012423 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 930170012424 L-aspartate oxidase; Provisional; Region: PRK06175 930170012425 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 930170012426 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 930170012427 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 930170012428 putative Iron-sulfur protein interface [polypeptide binding]; other site 930170012429 proximal heme binding site [chemical binding]; other site 930170012430 distal heme binding site [chemical binding]; other site 930170012431 putative dimer interface [polypeptide binding]; other site 930170012432 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 930170012433 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 930170012434 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930170012435 GIY-YIG motif/motif A; other site 930170012436 active site 930170012437 catalytic site [active] 930170012438 putative DNA binding site [nucleotide binding]; other site 930170012439 metal binding site [ion binding]; metal-binding site 930170012440 UvrB/uvrC motif; Region: UVR; pfam02151 930170012441 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 930170012442 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170012443 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930170012444 catalytic residues [active] 930170012445 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 930170012446 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 930170012447 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 930170012448 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 930170012449 Ligand binding site [chemical binding]; other site 930170012450 Electron transfer flavoprotein domain; Region: ETF; pfam01012 930170012451 enoyl-CoA hydratase; Provisional; Region: PRK07658 930170012452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930170012453 substrate binding site [chemical binding]; other site 930170012454 oxyanion hole (OAH) forming residues; other site 930170012455 trimer interface [polypeptide binding]; other site 930170012456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 930170012457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170012458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170012459 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 930170012460 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 930170012461 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 930170012462 acyl-activating enzyme (AAE) consensus motif; other site 930170012463 putative AMP binding site [chemical binding]; other site 930170012464 putative active site [active] 930170012465 putative CoA binding site [chemical binding]; other site 930170012466 DinB family; Region: DinB; pfam05163 930170012467 DinB superfamily; Region: DinB_2; pfam12867 930170012468 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170012469 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 930170012470 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 930170012471 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930170012472 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930170012473 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170012474 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 930170012475 Walker A/P-loop; other site 930170012476 ATP binding site [chemical binding]; other site 930170012477 Q-loop/lid; other site 930170012478 ABC transporter signature motif; other site 930170012479 Walker B; other site 930170012480 D-loop; other site 930170012481 H-loop/switch region; other site 930170012482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170012483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170012484 dimer interface [polypeptide binding]; other site 930170012485 phosphorylation site [posttranslational modification] 930170012486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170012487 ATP binding site [chemical binding]; other site 930170012488 Mg2+ binding site [ion binding]; other site 930170012489 G-X-G motif; other site 930170012490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170012491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170012492 active site 930170012493 phosphorylation site [posttranslational modification] 930170012494 intermolecular recognition site; other site 930170012495 dimerization interface [polypeptide binding]; other site 930170012496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170012497 DNA binding site [nucleotide binding] 930170012498 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 930170012499 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 930170012500 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 930170012501 putative RNA binding site [nucleotide binding]; other site 930170012502 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 930170012503 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 930170012504 TrkA-N domain; Region: TrkA_N; pfam02254 930170012505 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 930170012506 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 930170012507 active site 930170012508 catalytic site [active] 930170012509 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170012510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930170012511 Walker A/P-loop; other site 930170012512 ATP binding site [chemical binding]; other site 930170012513 Q-loop/lid; other site 930170012514 ABC transporter signature motif; other site 930170012515 Walker B; other site 930170012516 D-loop; other site 930170012517 H-loop/switch region; other site 930170012518 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930170012519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170012520 ABC-ATPase subunit interface; other site 930170012521 dimer interface [polypeptide binding]; other site 930170012522 putative PBP binding regions; other site 930170012523 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 930170012524 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930170012525 intersubunit interface [polypeptide binding]; other site 930170012526 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012527 heme-binding site [chemical binding]; other site 930170012528 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012529 heme-binding site [chemical binding]; other site 930170012530 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012531 heme-binding site [chemical binding]; other site 930170012532 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012533 heme-binding site [chemical binding]; other site 930170012534 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012535 heme-binding site [chemical binding]; other site 930170012536 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012537 heme-binding site [chemical binding]; other site 930170012538 heme uptake protein IsdC; Region: IsdC; TIGR03656 930170012539 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930170012540 heme-binding site [chemical binding]; other site 930170012541 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 930170012542 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 930170012543 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930170012544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170012545 RNA binding surface [nucleotide binding]; other site 930170012546 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 930170012547 probable active site [active] 930170012548 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 930170012549 MutS domain III; Region: MutS_III; pfam05192 930170012550 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 930170012551 Walker A/P-loop; other site 930170012552 ATP binding site [chemical binding]; other site 930170012553 Q-loop/lid; other site 930170012554 ABC transporter signature motif; other site 930170012555 Walker B; other site 930170012556 D-loop; other site 930170012557 H-loop/switch region; other site 930170012558 Smr domain; Region: Smr; pfam01713 930170012559 hypothetical protein; Provisional; Region: PRK08609 930170012560 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 930170012561 active site 930170012562 primer binding site [nucleotide binding]; other site 930170012563 NTP binding site [chemical binding]; other site 930170012564 metal binding triad [ion binding]; metal-binding site 930170012565 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 930170012566 active site 930170012567 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 930170012568 Colicin V production protein; Region: Colicin_V; pfam02674 930170012569 cell division protein ZapA; Provisional; Region: PRK14126 930170012570 ribonuclease HIII; Provisional; Region: PRK00996 930170012571 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 930170012572 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 930170012573 RNA/DNA hybrid binding site [nucleotide binding]; other site 930170012574 active site 930170012575 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 930170012576 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 930170012577 putative dimer interface [polypeptide binding]; other site 930170012578 putative anticodon binding site; other site 930170012579 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 930170012580 homodimer interface [polypeptide binding]; other site 930170012581 motif 1; other site 930170012582 motif 2; other site 930170012583 active site 930170012584 motif 3; other site 930170012585 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 930170012586 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930170012587 putative tRNA-binding site [nucleotide binding]; other site 930170012588 B3/4 domain; Region: B3_4; pfam03483 930170012589 tRNA synthetase B5 domain; Region: B5; smart00874 930170012590 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 930170012591 dimer interface [polypeptide binding]; other site 930170012592 motif 1; other site 930170012593 motif 3; other site 930170012594 motif 2; other site 930170012595 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 930170012596 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 930170012597 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 930170012598 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 930170012599 dimer interface [polypeptide binding]; other site 930170012600 motif 1; other site 930170012601 active site 930170012602 motif 2; other site 930170012603 motif 3; other site 930170012604 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930170012605 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 930170012606 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930170012607 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 930170012608 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170012609 Zn2+ binding site [ion binding]; other site 930170012610 Mg2+ binding site [ion binding]; other site 930170012611 CAAX protease self-immunity; Region: Abi; pfam02517 930170012612 CAAX protease self-immunity; Region: Abi; pfam02517 930170012613 RNA polymerase factor sigma-70; Validated; Region: PRK06811 930170012614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170012615 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930170012616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170012617 putative substrate translocation pore; other site 930170012618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170012619 HlyD family secretion protein; Region: HlyD_3; pfam13437 930170012620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170012621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170012622 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 930170012623 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930170012624 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 930170012625 oligomer interface [polypeptide binding]; other site 930170012626 active site 930170012627 metal binding site [ion binding]; metal-binding site 930170012628 dUTPase; Region: dUTPase_2; pfam08761 930170012629 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 930170012630 active site 930170012631 homodimer interface [polypeptide binding]; other site 930170012632 metal binding site [ion binding]; metal-binding site 930170012633 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 930170012634 23S rRNA binding site [nucleotide binding]; other site 930170012635 L21 binding site [polypeptide binding]; other site 930170012636 L13 binding site [polypeptide binding]; other site 930170012637 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 930170012638 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 930170012639 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 930170012640 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 930170012641 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 930170012642 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 930170012643 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930170012644 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 930170012645 active site 930170012646 dimer interface [polypeptide binding]; other site 930170012647 motif 1; other site 930170012648 motif 2; other site 930170012649 motif 3; other site 930170012650 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 930170012651 anticodon binding site; other site 930170012652 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 930170012653 primosomal protein DnaI; Reviewed; Region: PRK08939 930170012654 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 930170012655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170012656 Walker A motif; other site 930170012657 ATP binding site [chemical binding]; other site 930170012658 Walker B motif; other site 930170012659 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 930170012660 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930170012661 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 930170012662 ATP cone domain; Region: ATP-cone; pfam03477 930170012663 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 930170012664 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 930170012665 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 930170012666 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930170012667 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 930170012668 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 930170012669 CoA-binding site [chemical binding]; other site 930170012670 ATP-binding [chemical binding]; other site 930170012671 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 930170012672 Domain of unknown function DUF; Region: DUF204; pfam02659 930170012673 Domain of unknown function DUF; Region: DUF204; pfam02659 930170012674 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 930170012675 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 930170012676 DNA binding site [nucleotide binding] 930170012677 catalytic residue [active] 930170012678 H2TH interface [polypeptide binding]; other site 930170012679 putative catalytic residues [active] 930170012680 turnover-facilitating residue; other site 930170012681 intercalation triad [nucleotide binding]; other site 930170012682 8OG recognition residue [nucleotide binding]; other site 930170012683 putative reading head residues; other site 930170012684 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930170012685 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930170012686 DNA polymerase I; Provisional; Region: PRK05755 930170012687 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930170012688 active site 930170012689 metal binding site 1 [ion binding]; metal-binding site 930170012690 putative 5' ssDNA interaction site; other site 930170012691 metal binding site 3; metal-binding site 930170012692 metal binding site 2 [ion binding]; metal-binding site 930170012693 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930170012694 putative DNA binding site [nucleotide binding]; other site 930170012695 putative metal binding site [ion binding]; other site 930170012696 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 930170012697 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 930170012698 active site 930170012699 DNA binding site [nucleotide binding] 930170012700 catalytic site [active] 930170012701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170012702 dimerization interface [polypeptide binding]; other site 930170012703 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930170012704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170012705 putative active site [active] 930170012706 heme pocket [chemical binding]; other site 930170012707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170012708 dimer interface [polypeptide binding]; other site 930170012709 phosphorylation site [posttranslational modification] 930170012710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170012711 ATP binding site [chemical binding]; other site 930170012712 Mg2+ binding site [ion binding]; other site 930170012713 G-X-G motif; other site 930170012714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170012715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170012716 active site 930170012717 phosphorylation site [posttranslational modification] 930170012718 intermolecular recognition site; other site 930170012719 dimerization interface [polypeptide binding]; other site 930170012720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170012721 DNA binding site [nucleotide binding] 930170012722 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 930170012723 active site 2 [active] 930170012724 active site 1 [active] 930170012725 malate dehydrogenase; Reviewed; Region: PRK06223 930170012726 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 930170012727 NAD(P) binding site [chemical binding]; other site 930170012728 dimer interface [polypeptide binding]; other site 930170012729 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170012730 substrate binding site [chemical binding]; other site 930170012731 isocitrate dehydrogenase; Reviewed; Region: PRK07006 930170012732 isocitrate dehydrogenase; Validated; Region: PRK07362 930170012733 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 930170012734 dimer interface [polypeptide binding]; other site 930170012735 Citrate synthase; Region: Citrate_synt; pfam00285 930170012736 active site 930170012737 citrylCoA binding site [chemical binding]; other site 930170012738 oxalacetate/citrate binding site [chemical binding]; other site 930170012739 coenzyme A binding site [chemical binding]; other site 930170012740 catalytic triad [active] 930170012741 Protein of unknown function (DUF441); Region: DUF441; pfam04284 930170012742 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 930170012743 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930170012744 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 930170012745 pyruvate kinase; Provisional; Region: PRK06354 930170012746 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 930170012747 domain interfaces; other site 930170012748 active site 930170012749 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 930170012750 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 930170012751 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 930170012752 active site 930170012753 ADP/pyrophosphate binding site [chemical binding]; other site 930170012754 dimerization interface [polypeptide binding]; other site 930170012755 allosteric effector site; other site 930170012756 fructose-1,6-bisphosphate binding site; other site 930170012757 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 930170012758 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 930170012759 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 930170012760 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 930170012761 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 930170012762 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930170012763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170012764 DNA-binding site [nucleotide binding]; DNA binding site 930170012765 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 930170012766 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930170012767 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 930170012768 putative NAD(P) binding site [chemical binding]; other site 930170012769 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 930170012770 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 930170012771 active site 930170012772 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 930170012773 generic binding surface II; other site 930170012774 generic binding surface I; other site 930170012775 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 930170012776 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 930170012777 DHH family; Region: DHH; pfam01368 930170012778 DHHA1 domain; Region: DHHA1; pfam02272 930170012779 YtpI-like protein; Region: YtpI; pfam14007 930170012780 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 930170012781 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 930170012782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170012783 DNA-binding site [nucleotide binding]; DNA binding site 930170012784 DRTGG domain; Region: DRTGG; pfam07085 930170012785 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 930170012786 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 930170012787 active site 2 [active] 930170012788 active site 1 [active] 930170012789 metal-dependent hydrolase; Provisional; Region: PRK00685 930170012790 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930170012791 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930170012792 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930170012793 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930170012794 active site 930170012795 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 930170012796 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 930170012797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170012798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170012799 Coenzyme A binding pocket [chemical binding]; other site 930170012800 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 930170012801 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170012802 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170012803 putative active site [active] 930170012804 putative NTP binding site [chemical binding]; other site 930170012805 putative nucleic acid binding site [nucleotide binding]; other site 930170012806 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170012807 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 930170012808 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 930170012809 hexamer interface [polypeptide binding]; other site 930170012810 ligand binding site [chemical binding]; other site 930170012811 putative active site [active] 930170012812 NAD(P) binding site [chemical binding]; other site 930170012813 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 930170012814 classical (c) SDRs; Region: SDR_c; cd05233 930170012815 NAD(P) binding site [chemical binding]; other site 930170012816 active site 930170012817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930170012818 Ligand Binding Site [chemical binding]; other site 930170012819 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 930170012820 argininosuccinate lyase; Provisional; Region: PRK00855 930170012821 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 930170012822 active sites [active] 930170012823 tetramer interface [polypeptide binding]; other site 930170012824 argininosuccinate synthase; Provisional; Region: PRK13820 930170012825 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 930170012826 ANP binding site [chemical binding]; other site 930170012827 Substrate Binding Site II [chemical binding]; other site 930170012828 Substrate Binding Site I [chemical binding]; other site 930170012829 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170012830 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170012831 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170012832 EcsC protein family; Region: EcsC; pfam12787 930170012833 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 930170012834 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 930170012835 nudix motif; other site 930170012836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 930170012837 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170012838 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930170012839 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 930170012840 propionate/acetate kinase; Provisional; Region: PRK12379 930170012841 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 930170012842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170012843 S-adenosylmethionine binding site [chemical binding]; other site 930170012844 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 930170012845 dimer interface [polypeptide binding]; other site 930170012846 catalytic triad [active] 930170012847 peroxidatic and resolving cysteines [active] 930170012848 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 930170012849 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 930170012850 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 930170012851 ATP-NAD kinase; Region: NAD_kinase; pfam01513 930170012852 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 930170012853 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 930170012854 active site 930170012855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170012856 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930170012857 dimer interface [polypeptide binding]; other site 930170012858 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 930170012859 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 930170012860 active site 930170012861 acyl-activating enzyme (AAE) consensus motif; other site 930170012862 putative CoA binding site [chemical binding]; other site 930170012863 AMP binding site [chemical binding]; other site 930170012864 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 930170012865 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 930170012866 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 930170012867 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 930170012868 Ligand Binding Site [chemical binding]; other site 930170012869 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930170012870 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930170012871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170012872 catalytic residue [active] 930170012873 septation ring formation regulator EzrA; Provisional; Region: PRK04778 930170012874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170012875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170012876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930170012877 dimerization interface [polypeptide binding]; other site 930170012878 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170012879 EamA-like transporter family; Region: EamA; pfam00892 930170012880 EamA-like transporter family; Region: EamA; pfam00892 930170012881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170012882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170012883 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 930170012884 GAF domain; Region: GAF_2; pfam13185 930170012885 methionine gamma-lyase; Provisional; Region: PRK06767 930170012886 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930170012887 homodimer interface [polypeptide binding]; other site 930170012888 substrate-cofactor binding pocket; other site 930170012889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170012890 catalytic residue [active] 930170012891 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 930170012892 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 930170012893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170012894 RNA binding surface [nucleotide binding]; other site 930170012895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170012896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170012897 non-specific DNA binding site [nucleotide binding]; other site 930170012898 salt bridge; other site 930170012899 sequence-specific DNA binding site [nucleotide binding]; other site 930170012900 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 930170012901 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 930170012902 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 930170012903 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 930170012904 active site 930170012905 HIGH motif; other site 930170012906 dimer interface [polypeptide binding]; other site 930170012907 KMSKS motif; other site 930170012908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170012909 RNA binding surface [nucleotide binding]; other site 930170012910 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170012911 acetyl-CoA synthetase; Provisional; Region: PRK04319 930170012912 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 930170012913 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 930170012914 active site 930170012915 acyl-activating enzyme (AAE) consensus motif; other site 930170012916 putative CoA binding site [chemical binding]; other site 930170012917 AMP binding site [chemical binding]; other site 930170012918 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170012919 Coenzyme A binding pocket [chemical binding]; other site 930170012920 FOG: CBS domain [General function prediction only]; Region: COG0517 930170012921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 930170012922 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 930170012923 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 930170012924 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 930170012925 active site 930170012926 Zn binding site [ion binding]; other site 930170012927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170012928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170012929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170012930 active site 930170012931 phosphorylation site [posttranslational modification] 930170012932 intermolecular recognition site; other site 930170012933 dimerization interface [polypeptide binding]; other site 930170012934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170012935 DNA binding site [nucleotide binding] 930170012936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170012937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170012938 dimerization interface [polypeptide binding]; other site 930170012939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170012940 dimer interface [polypeptide binding]; other site 930170012941 phosphorylation site [posttranslational modification] 930170012942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170012943 ATP binding site [chemical binding]; other site 930170012944 Mg2+ binding site [ion binding]; other site 930170012945 G-X-G motif; other site 930170012946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930170012947 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930170012948 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930170012949 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930170012950 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 930170012951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930170012952 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930170012953 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 930170012954 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 930170012955 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 930170012956 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 930170012957 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 930170012958 catabolite control protein A; Region: ccpA; TIGR01481 930170012959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170012960 DNA binding site [nucleotide binding] 930170012961 domain linker motif; other site 930170012962 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 930170012963 dimerization interface [polypeptide binding]; other site 930170012964 effector binding site; other site 930170012965 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 930170012966 putative dimer interface [polypeptide binding]; other site 930170012967 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 930170012968 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 930170012969 putative dimer interface [polypeptide binding]; other site 930170012970 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 930170012971 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 930170012972 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 930170012973 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 930170012974 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 930170012975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170012976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170012977 Coenzyme A binding pocket [chemical binding]; other site 930170012978 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170012979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170012980 Coenzyme A binding pocket [chemical binding]; other site 930170012981 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 930170012982 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930170012983 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930170012984 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930170012985 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 930170012986 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 930170012987 active site 930170012988 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930170012989 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930170012990 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930170012991 MAEBL; Provisional; Region: PTZ00121 930170012992 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930170012993 putative tRNA-binding site [nucleotide binding]; other site 930170012994 hypothetical protein; Provisional; Region: PRK13668 930170012995 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170012996 catalytic residues [active] 930170012997 NTPase; Reviewed; Region: PRK03114 930170012998 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930170012999 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 930170013000 oligomer interface [polypeptide binding]; other site 930170013001 active site 930170013002 metal binding site [ion binding]; metal-binding site 930170013003 Predicted small secreted protein [Function unknown]; Region: COG5584 930170013004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170013005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170013006 S-adenosylmethionine binding site [chemical binding]; other site 930170013007 YtzH-like protein; Region: YtzH; pfam14165 930170013008 Phosphotransferase enzyme family; Region: APH; pfam01636 930170013009 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930170013010 active site 930170013011 substrate binding site [chemical binding]; other site 930170013012 ATP binding site [chemical binding]; other site 930170013013 pullulanase, type I; Region: pulA_typeI; TIGR02104 930170013014 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 930170013015 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 930170013016 Ca binding site [ion binding]; other site 930170013017 active site 930170013018 catalytic site [active] 930170013019 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 930170013020 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 930170013021 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 930170013022 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 930170013023 dipeptidase PepV; Reviewed; Region: PRK07318 930170013024 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 930170013025 active site 930170013026 metal binding site [ion binding]; metal-binding site 930170013027 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 930170013028 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930170013029 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170013030 RNA binding surface [nucleotide binding]; other site 930170013031 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 930170013032 active site 930170013033 uracil binding [chemical binding]; other site 930170013034 stage V sporulation protein B; Region: spore_V_B; TIGR02900 930170013035 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930170013036 HI0933-like protein; Region: HI0933_like; pfam03486 930170013037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170013038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170013039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170013040 putative substrate translocation pore; other site 930170013041 indole-3-acetic acid-amido synthetase; Region: PLN02249 930170013042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170013043 dimerization interface [polypeptide binding]; other site 930170013044 putative DNA binding site [nucleotide binding]; other site 930170013045 putative Zn2+ binding site [ion binding]; other site 930170013046 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 930170013047 putative hydrophobic ligand binding site [chemical binding]; other site 930170013048 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 930170013049 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 930170013050 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 930170013051 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 930170013052 glucose-1-dehydrogenase; Provisional; Region: PRK08936 930170013053 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 930170013054 NAD binding site [chemical binding]; other site 930170013055 homodimer interface [polypeptide binding]; other site 930170013056 active site 930170013057 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930170013058 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 930170013059 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 930170013060 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 930170013061 MoaE interaction surface [polypeptide binding]; other site 930170013062 MoeB interaction surface [polypeptide binding]; other site 930170013063 thiocarboxylated glycine; other site 930170013064 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 930170013065 MoaE homodimer interface [polypeptide binding]; other site 930170013066 MoaD interaction [polypeptide binding]; other site 930170013067 active site residues [active] 930170013068 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 930170013069 Walker A motif; other site 930170013070 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930170013071 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930170013072 dimer interface [polypeptide binding]; other site 930170013073 putative functional site; other site 930170013074 putative MPT binding site; other site 930170013075 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 930170013076 trimer interface [polypeptide binding]; other site 930170013077 dimer interface [polypeptide binding]; other site 930170013078 putative active site [active] 930170013079 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 930170013080 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930170013081 ATP binding site [chemical binding]; other site 930170013082 substrate interface [chemical binding]; other site 930170013083 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 930170013084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170013085 FeS/SAM binding site; other site 930170013086 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 930170013087 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 930170013088 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930170013089 active site residue [active] 930170013090 homoserine O-acetyltransferase; Provisional; Region: PRK06765 930170013091 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930170013092 Vicilin N terminal region; Region: Vicilin_N; pfam04702 930170013093 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 930170013094 Spore germination protein; Region: Spore_permease; pfam03845 930170013095 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 930170013096 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 930170013097 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 930170013098 putative nucleotide binding site [chemical binding]; other site 930170013099 putative metal binding site [ion binding]; other site 930170013100 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 930170013101 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 930170013102 HIGH motif; other site 930170013103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930170013104 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 930170013105 active site 930170013106 KMSKS motif; other site 930170013107 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 930170013108 tRNA binding surface [nucleotide binding]; other site 930170013109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170013110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170013111 putative substrate translocation pore; other site 930170013112 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170013113 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170013114 putative active site [active] 930170013115 putative NTP binding site [chemical binding]; other site 930170013116 putative nucleic acid binding site [nucleotide binding]; other site 930170013117 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170013118 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930170013119 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930170013120 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 930170013121 TrkA-C domain; Region: TrkA_C; pfam02080 930170013122 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 930170013123 Int/Topo IB signature motif; other site 930170013124 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170013125 FtsX-like permease family; Region: FtsX; pfam02687 930170013126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170013127 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170013128 Walker A/P-loop; other site 930170013129 ATP binding site [chemical binding]; other site 930170013130 Q-loop/lid; other site 930170013131 ABC transporter signature motif; other site 930170013132 Walker B; other site 930170013133 D-loop; other site 930170013134 H-loop/switch region; other site 930170013135 Predicted membrane protein [Function unknown]; Region: COG2311 930170013136 Protein of unknown function (DUF418); Region: DUF418; cl12135 930170013137 Protein of unknown function (DUF418); Region: DUF418; pfam04235 930170013138 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 930170013139 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 930170013140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170013141 FeS/SAM binding site; other site 930170013142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170013143 S-adenosylmethionine binding site [chemical binding]; other site 930170013144 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 930170013145 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170013146 Walker A/P-loop; other site 930170013147 ATP binding site [chemical binding]; other site 930170013148 Q-loop/lid; other site 930170013149 ABC transporter signature motif; other site 930170013150 Walker B; other site 930170013151 D-loop; other site 930170013152 H-loop/switch region; other site 930170013153 aspartate racemase; Region: asp_race; TIGR00035 930170013154 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 930170013155 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 930170013156 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 930170013157 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 930170013158 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 930170013159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930170013160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170013161 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 930170013162 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 930170013163 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 930170013164 trimer interface [polypeptide binding]; other site 930170013165 putative metal binding site [ion binding]; other site 930170013166 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930170013167 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 930170013168 active site 930170013169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930170013170 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 930170013171 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 930170013172 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 930170013173 GTP binding site; other site 930170013174 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 930170013175 MPT binding site; other site 930170013176 trimer interface [polypeptide binding]; other site 930170013177 S-adenosylmethionine synthetase; Validated; Region: PRK05250 930170013178 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 930170013179 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 930170013180 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 930170013181 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 930170013182 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 930170013183 active site 930170013184 substrate-binding site [chemical binding]; other site 930170013185 metal-binding site [ion binding] 930170013186 ATP binding site [chemical binding]; other site 930170013187 ATP synthase I chain; Region: ATP_synt_I; pfam03899 930170013188 EamA-like transporter family; Region: EamA; pfam00892 930170013189 EamA-like transporter family; Region: EamA; pfam00892 930170013190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 930170013191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170013192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013193 ATP binding site [chemical binding]; other site 930170013194 Mg2+ binding site [ion binding]; other site 930170013195 G-X-G motif; other site 930170013196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170013197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170013198 dimer interface [polypeptide binding]; other site 930170013199 phosphorylation site [posttranslational modification] 930170013200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013201 ATP binding site [chemical binding]; other site 930170013202 Mg2+ binding site [ion binding]; other site 930170013203 G-X-G motif; other site 930170013204 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930170013205 Secretory lipase; Region: LIP; pfam03583 930170013206 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 930170013207 Sulfatase; Region: Sulfatase; pfam00884 930170013208 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 930170013209 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 930170013210 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 930170013211 NMT1-like family; Region: NMT1_2; pfam13379 930170013212 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930170013213 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930170013214 Walker A/P-loop; other site 930170013215 ATP binding site [chemical binding]; other site 930170013216 Q-loop/lid; other site 930170013217 ABC transporter signature motif; other site 930170013218 Walker B; other site 930170013219 D-loop; other site 930170013220 H-loop/switch region; other site 930170013221 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930170013222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170013223 dimer interface [polypeptide binding]; other site 930170013224 conserved gate region; other site 930170013225 putative PBP binding loops; other site 930170013226 ABC-ATPase subunit interface; other site 930170013227 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 930170013228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170013229 motif II; other site 930170013230 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 930170013231 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 930170013232 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 930170013233 nudix motif; other site 930170013234 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 930170013235 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 930170013236 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 930170013237 S-ribosylhomocysteinase; Provisional; Region: PRK02260 930170013238 Haemolytic domain; Region: Haemolytic; pfam01809 930170013239 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 930170013240 active site clefts [active] 930170013241 zinc binding site [ion binding]; other site 930170013242 dimer interface [polypeptide binding]; other site 930170013243 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 930170013244 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 930170013245 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 930170013246 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 930170013247 S-layer homology domain; Region: SLH; pfam00395 930170013248 S-layer homology domain; Region: SLH; pfam00395 930170013249 S-layer homology domain; Region: SLH; pfam00395 930170013250 Excalibur calcium-binding domain; Region: Excalibur; smart00894 930170013251 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930170013252 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930170013253 putative active site [active] 930170013254 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170013255 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170013256 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170013257 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170013258 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 930170013259 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 930170013260 Predicted membrane protein [Function unknown]; Region: COG3766 930170013261 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 930170013262 hypothetical protein; Provisional; Region: PRK12473 930170013263 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 930170013264 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 930170013265 G1 box; other site 930170013266 GTP/Mg2+ binding site [chemical binding]; other site 930170013267 Switch I region; other site 930170013268 G2 box; other site 930170013269 G3 box; other site 930170013270 Switch II region; other site 930170013271 G4 box; other site 930170013272 G5 box; other site 930170013273 Nucleoside recognition; Region: Gate; pfam07670 930170013274 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 930170013275 Nucleoside recognition; Region: Gate; pfam07670 930170013276 FeoA domain; Region: FeoA; pfam04023 930170013277 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 930170013278 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930170013279 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170013280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170013281 dimerization interface [polypeptide binding]; other site 930170013282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170013283 dimer interface [polypeptide binding]; other site 930170013284 phosphorylation site [posttranslational modification] 930170013285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013286 ATP binding site [chemical binding]; other site 930170013287 Mg2+ binding site [ion binding]; other site 930170013288 G-X-G motif; other site 930170013289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170013290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170013291 active site 930170013292 phosphorylation site [posttranslational modification] 930170013293 intermolecular recognition site; other site 930170013294 dimerization interface [polypeptide binding]; other site 930170013295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170013296 DNA binding site [nucleotide binding] 930170013297 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 930170013298 active site 930170013299 catalytic site [active] 930170013300 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170013301 active site 930170013302 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 930170013303 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930170013304 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 930170013305 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 930170013306 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 930170013307 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 930170013308 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930170013309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170013310 S-adenosylmethionine binding site [chemical binding]; other site 930170013311 FtsX-like permease family; Region: FtsX; pfam02687 930170013312 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170013313 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170013314 Walker A/P-loop; other site 930170013315 ATP binding site [chemical binding]; other site 930170013316 Q-loop/lid; other site 930170013317 ABC transporter signature motif; other site 930170013318 Walker B; other site 930170013319 D-loop; other site 930170013320 H-loop/switch region; other site 930170013321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930170013322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930170013323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 930170013324 Predicted integral membrane protein [Function unknown]; Region: COG5658 930170013325 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930170013326 SdpI/YhfL protein family; Region: SdpI; pfam13630 930170013327 Predicted integral membrane protein [Function unknown]; Region: COG5658 930170013328 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930170013329 SdpI/YhfL protein family; Region: SdpI; pfam13630 930170013330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170013331 dimerization interface [polypeptide binding]; other site 930170013332 putative DNA binding site [nucleotide binding]; other site 930170013333 putative Zn2+ binding site [ion binding]; other site 930170013334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170013335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170013336 active site 930170013337 phosphorylation site [posttranslational modification] 930170013338 intermolecular recognition site; other site 930170013339 dimerization interface [polypeptide binding]; other site 930170013340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170013341 DNA binding site [nucleotide binding] 930170013342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170013343 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 930170013344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013345 ATP binding site [chemical binding]; other site 930170013346 Mg2+ binding site [ion binding]; other site 930170013347 G-X-G motif; other site 930170013348 FtsX-like permease family; Region: FtsX; pfam02687 930170013349 FtsX-like permease family; Region: FtsX; pfam02687 930170013350 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170013351 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170013352 Walker A/P-loop; other site 930170013353 ATP binding site [chemical binding]; other site 930170013354 Q-loop/lid; other site 930170013355 ABC transporter signature motif; other site 930170013356 Walker B; other site 930170013357 D-loop; other site 930170013358 H-loop/switch region; other site 930170013359 FtsX-like permease family; Region: FtsX; pfam02687 930170013360 fructuronate transporter; Provisional; Region: PRK10034; cl15264 930170013361 GntP family permease; Region: GntP_permease; pfam02447 930170013362 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930170013363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170013364 DNA-binding site [nucleotide binding]; DNA binding site 930170013365 UTRA domain; Region: UTRA; pfam07702 930170013366 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930170013367 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 930170013368 substrate binding site [chemical binding]; other site 930170013369 ATP binding site [chemical binding]; other site 930170013370 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 930170013371 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 930170013372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170013373 catalytic residue [active] 930170013374 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 930170013375 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 930170013376 active site 930170013377 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930170013378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170013379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170013380 dimerization interface [polypeptide binding]; other site 930170013381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170013382 dimer interface [polypeptide binding]; other site 930170013383 phosphorylation site [posttranslational modification] 930170013384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013385 ATP binding site [chemical binding]; other site 930170013386 Mg2+ binding site [ion binding]; other site 930170013387 G-X-G motif; other site 930170013388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170013389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170013390 active site 930170013391 phosphorylation site [posttranslational modification] 930170013392 intermolecular recognition site; other site 930170013393 dimerization interface [polypeptide binding]; other site 930170013394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170013395 DNA binding site [nucleotide binding] 930170013396 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930170013397 MULE transposase domain; Region: MULE; pfam10551 930170013398 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 930170013399 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 930170013400 active site 930170013401 octamer interface [polypeptide binding]; other site 930170013402 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 930170013403 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 930170013404 acyl-activating enzyme (AAE) consensus motif; other site 930170013405 putative AMP binding site [chemical binding]; other site 930170013406 putative active site [active] 930170013407 putative CoA binding site [chemical binding]; other site 930170013408 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930170013409 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 930170013410 substrate binding site [chemical binding]; other site 930170013411 oxyanion hole (OAH) forming residues; other site 930170013412 trimer interface [polypeptide binding]; other site 930170013413 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 930170013414 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930170013415 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 930170013416 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 930170013417 dimer interface [polypeptide binding]; other site 930170013418 tetramer interface [polypeptide binding]; other site 930170013419 PYR/PP interface [polypeptide binding]; other site 930170013420 TPP binding site [chemical binding]; other site 930170013421 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 930170013422 TPP-binding site; other site 930170013423 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 930170013424 chorismate binding enzyme; Region: Chorismate_bind; cl10555 930170013425 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 930170013426 UbiA prenyltransferase family; Region: UbiA; pfam01040 930170013427 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 930170013428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930170013429 DNA-binding site [nucleotide binding]; DNA binding site 930170013430 RNA-binding motif; other site 930170013431 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 930170013432 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 930170013433 active site flap/lid [active] 930170013434 nucleophilic elbow; other site 930170013435 catalytic triad [active] 930170013436 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 930170013437 homodimer interface [polypeptide binding]; other site 930170013438 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 930170013439 active site pocket [active] 930170013440 glycogen synthase; Provisional; Region: glgA; PRK00654 930170013441 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 930170013442 ADP-binding pocket [chemical binding]; other site 930170013443 homodimer interface [polypeptide binding]; other site 930170013444 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 930170013445 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 930170013446 ligand binding site; other site 930170013447 oligomer interface; other site 930170013448 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 930170013449 dimer interface [polypeptide binding]; other site 930170013450 N-terminal domain interface [polypeptide binding]; other site 930170013451 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 930170013452 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 930170013453 ligand binding site; other site 930170013454 oligomer interface; other site 930170013455 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 930170013456 dimer interface [polypeptide binding]; other site 930170013457 N-terminal domain interface [polypeptide binding]; other site 930170013458 sulfate 1 binding site; other site 930170013459 glycogen branching enzyme; Provisional; Region: PRK12313 930170013460 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 930170013461 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 930170013462 active site 930170013463 catalytic site [active] 930170013464 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 930170013465 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 930170013466 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 930170013467 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 930170013468 putative active site [active] 930170013469 catalytic triad [active] 930170013470 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 930170013471 PA/protease domain interface [polypeptide binding]; other site 930170013472 putative integrin binding motif; other site 930170013473 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 930170013474 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 930170013475 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 930170013476 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 930170013477 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930170013478 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170013479 NAD binding site [chemical binding]; other site 930170013480 dimer interface [polypeptide binding]; other site 930170013481 substrate binding site [chemical binding]; other site 930170013482 potential protein location (hypothetical protein YBT020_24035 [Bacillus thuringiensis YBT-020]) that overlaps RNA (tRNA-E) 930170013483 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 930170013484 MgtC family; Region: MgtC; pfam02308 930170013485 Ion channel; Region: Ion_trans_2; pfam07885 930170013486 TrkA-N domain; Region: TrkA_N; pfam02254 930170013487 YugN-like family; Region: YugN; pfam08868 930170013488 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 930170013489 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 930170013490 active site 930170013491 dimer interface [polypeptide binding]; other site 930170013492 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 930170013493 dimer interface [polypeptide binding]; other site 930170013494 active site 930170013495 Domain of unknown function (DUF378); Region: DUF378; pfam04070 930170013496 general stress protein 13; Validated; Region: PRK08059 930170013497 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930170013498 RNA binding site [nucleotide binding]; other site 930170013499 hypothetical protein; Validated; Region: PRK07682 930170013500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170013501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170013502 homodimer interface [polypeptide binding]; other site 930170013503 catalytic residue [active] 930170013504 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930170013505 AsnC family; Region: AsnC_trans_reg; pfam01037 930170013506 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 930170013507 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 930170013508 dimerization interface [polypeptide binding]; other site 930170013509 ligand binding site [chemical binding]; other site 930170013510 NADP binding site [chemical binding]; other site 930170013511 catalytic site [active] 930170013512 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 930170013513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930170013514 nucleophilic elbow; other site 930170013515 catalytic triad; other site 930170013516 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 930170013517 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 930170013518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930170013519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170013520 homodimer interface [polypeptide binding]; other site 930170013521 catalytic residue [active] 930170013522 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 930170013523 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 930170013524 E-class dimer interface [polypeptide binding]; other site 930170013525 P-class dimer interface [polypeptide binding]; other site 930170013526 active site 930170013527 Cu2+ binding site [ion binding]; other site 930170013528 Zn2+ binding site [ion binding]; other site 930170013529 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 930170013530 Kinase associated protein B; Region: KapB; pfam08810 930170013531 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 930170013532 active site 930170013533 catalytic site [active] 930170013534 substrate binding site [chemical binding]; other site 930170013535 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 930170013536 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 930170013537 transmembrane helices; other site 930170013538 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930170013539 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 930170013540 active site 930170013541 glycyl-tRNA synthetase; Provisional; Region: PRK04173 930170013542 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930170013543 motif 1; other site 930170013544 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 930170013545 active site 930170013546 motif 2; other site 930170013547 motif 3; other site 930170013548 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 930170013549 anticodon binding site; other site 930170013550 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930170013551 CoenzymeA binding site [chemical binding]; other site 930170013552 subunit interaction site [polypeptide binding]; other site 930170013553 PHB binding site; other site 930170013554 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 930170013555 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 930170013556 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 930170013557 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 930170013558 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930170013559 active site 930170013560 tetramer interface; other site 930170013561 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 930170013562 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 930170013563 active site 930170013564 substrate binding site [chemical binding]; other site 930170013565 metal binding site [ion binding]; metal-binding site 930170013566 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 930170013567 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 930170013568 multifunctional aminopeptidase A; Provisional; Region: PRK00913 930170013569 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 930170013570 interface (dimer of trimers) [polypeptide binding]; other site 930170013571 Substrate-binding/catalytic site; other site 930170013572 Zn-binding sites [ion binding]; other site 930170013573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930170013574 Putative membrane protein; Region: YuiB; pfam14068 930170013575 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930170013576 nudix motif; other site 930170013577 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930170013578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170013579 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930170013580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170013581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170013582 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013583 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013584 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013585 Domain of unknown function DUF11; Region: DUF11; cl17728 930170013586 Domain of unknown function DUF11; Region: DUF11; pfam01345 930170013587 Domain of unknown function DUF11; Region: DUF11; pfam01345 930170013588 Domain of unknown function DUF11; Region: DUF11; cl17728 930170013589 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013590 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013591 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013592 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013593 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013594 conserved repeat domain; Region: B_ant_repeat; TIGR01451 930170013595 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013596 Domain of unknown function DUF11; Region: DUF11; cl17728 930170013597 Domain of unknown function DUF11; Region: DUF11; pfam01345 930170013598 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 930170013599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 930170013600 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170013601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170013602 putative substrate translocation pore; other site 930170013603 Helix-turn-helix domain; Region: HTH_36; pfam13730 930170013604 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930170013605 Protein of unknown function (DUF523); Region: DUF523; pfam04463 930170013606 Helix-turn-helix domain; Region: HTH_36; pfam13730 930170013607 Replication-relaxation; Region: Replic_Relax; pfam13814 930170013608 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930170013609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170013610 non-specific DNA binding site [nucleotide binding]; other site 930170013611 salt bridge; other site 930170013612 sequence-specific DNA binding site [nucleotide binding]; other site 930170013613 hypothetical protein; Region: PHA02436 930170013614 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 930170013615 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 930170013616 active site 930170013617 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 930170013618 Holin family; Region: Phage_holin_4; pfam05105 930170013619 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 930170013620 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 930170013621 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 930170013622 Phage tail protein; Region: Sipho_tail; cl17486 930170013623 Phage-related minor tail protein [Function unknown]; Region: COG5280 930170013624 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 930170013625 Phage-related protein [Function unknown]; Region: COG5412 930170013626 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 930170013627 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 930170013628 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 930170013629 Phage capsid family; Region: Phage_capsid; pfam05065 930170013630 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 930170013631 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 930170013632 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 930170013633 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 930170013634 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930170013635 active site 930170013636 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 930170013637 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 930170013638 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 930170013639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170013640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170013641 Walker A motif; other site 930170013642 ATP binding site [chemical binding]; other site 930170013643 Walker B motif; other site 930170013644 arginine finger; other site 930170013645 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 930170013646 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 930170013647 ORF6C domain; Region: ORF6C; pfam10552 930170013648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170013649 non-specific DNA binding site [nucleotide binding]; other site 930170013650 salt bridge; other site 930170013651 sequence-specific DNA binding site [nucleotide binding]; other site 930170013652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170013653 non-specific DNA binding site [nucleotide binding]; other site 930170013654 salt bridge; other site 930170013655 sequence-specific DNA binding site [nucleotide binding]; other site 930170013656 integrase; Provisional; Region: int; PHA02601 930170013657 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930170013658 Int/Topo IB signature motif; other site 930170013659 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 930170013660 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 930170013661 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 930170013662 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930170013663 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930170013664 hypothetical protein; Provisional; Region: PRK13669 930170013665 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930170013666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170013667 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 930170013668 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170013669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170013670 Walker A/P-loop; other site 930170013671 ATP binding site [chemical binding]; other site 930170013672 Q-loop/lid; other site 930170013673 ABC transporter signature motif; other site 930170013674 Walker B; other site 930170013675 D-loop; other site 930170013676 H-loop/switch region; other site 930170013677 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 930170013678 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 930170013679 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 930170013680 PhnA protein; Region: PhnA; pfam03831 930170013681 Probable transposase; Region: OrfB_IS605; pfam01385 930170013682 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170013683 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170013684 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 930170013685 PQQ-like domain; Region: PQQ_2; pfam13360 930170013686 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 930170013687 PQQ-like domain; Region: PQQ_2; pfam13360 930170013688 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 930170013689 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930170013690 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 930170013691 CAAX protease self-immunity; Region: Abi; pfam02517 930170013692 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 930170013693 active site 930170013694 NTP binding site [chemical binding]; other site 930170013695 metal binding triad [ion binding]; metal-binding site 930170013696 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 930170013697 NifU-like domain; Region: NifU; pfam01106 930170013698 spore coat protein YutH; Region: spore_yutH; TIGR02905 930170013699 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 930170013700 tetramer interfaces [polypeptide binding]; other site 930170013701 binuclear metal-binding site [ion binding]; other site 930170013702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930170013703 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170013704 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 930170013705 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170013706 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 930170013707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170013708 active site 930170013709 motif I; other site 930170013710 motif II; other site 930170013711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170013712 Predicted transcriptional regulator [Transcription]; Region: COG2345 930170013713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170013714 putative Zn2+ binding site [ion binding]; other site 930170013715 putative DNA binding site [nucleotide binding]; other site 930170013716 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 930170013717 Uncharacterized conserved protein [Function unknown]; Region: COG2445 930170013718 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 930170013719 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 930170013720 putative active site [active] 930170013721 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 930170013722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 930170013723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170013724 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930170013725 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 930170013726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170013727 RNA binding surface [nucleotide binding]; other site 930170013728 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 930170013729 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 930170013730 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170013731 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 930170013732 DNA binding residues [nucleotide binding] 930170013733 dimer interface [polypeptide binding]; other site 930170013734 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 930170013735 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 930170013736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930170013737 catalytic core [active] 930170013738 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 930170013739 putative deacylase active site [active] 930170013740 lipoyl synthase; Provisional; Region: PRK05481 930170013741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170013742 FeS/SAM binding site; other site 930170013743 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170013744 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170013745 sporulation protein YunB; Region: spo_yunB; TIGR02832 930170013746 Uncharacterized conserved protein [Function unknown]; Region: COG3377 930170013747 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930170013748 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 930170013749 active site 930170013750 metal binding site [ion binding]; metal-binding site 930170013751 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930170013752 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930170013753 MULE transposase domain; Region: MULE; pfam10551 930170013754 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 930170013755 FeS assembly protein SufB; Region: sufB; TIGR01980 930170013756 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 930170013757 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 930170013758 trimerization site [polypeptide binding]; other site 930170013759 active site 930170013760 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 930170013761 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 930170013762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930170013763 catalytic residue [active] 930170013764 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 930170013765 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 930170013766 FeS assembly protein SufD; Region: sufD; TIGR01981 930170013767 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 930170013768 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 930170013769 Walker A/P-loop; other site 930170013770 ATP binding site [chemical binding]; other site 930170013771 Q-loop/lid; other site 930170013772 ABC transporter signature motif; other site 930170013773 Walker B; other site 930170013774 D-loop; other site 930170013775 H-loop/switch region; other site 930170013776 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930170013777 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930170013778 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930170013779 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930170013780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930170013781 ABC-ATPase subunit interface; other site 930170013782 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 930170013783 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930170013784 Walker A/P-loop; other site 930170013785 ATP binding site [chemical binding]; other site 930170013786 Q-loop/lid; other site 930170013787 ABC transporter signature motif; other site 930170013788 Walker B; other site 930170013789 D-loop; other site 930170013790 H-loop/switch region; other site 930170013791 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 930170013792 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930170013793 catalytic residues [active] 930170013794 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 930170013795 putative active site [active] 930170013796 putative metal binding site [ion binding]; other site 930170013797 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 930170013798 lipoyl attachment site [posttranslational modification]; other site 930170013799 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 930170013800 ArsC family; Region: ArsC; pfam03960 930170013801 putative ArsC-like catalytic residues; other site 930170013802 putative TRX-like catalytic residues [active] 930170013803 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 930170013804 active site 930170013805 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 930170013806 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 930170013807 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 930170013808 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930170013809 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170013810 NAD binding site [chemical binding]; other site 930170013811 dimer interface [polypeptide binding]; other site 930170013812 substrate binding site [chemical binding]; other site 930170013813 Coat F domain; Region: Coat_F; pfam07875 930170013814 CAAX protease self-immunity; Region: Abi; pfam02517 930170013815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170013816 salt bridge; other site 930170013817 non-specific DNA binding site [nucleotide binding]; other site 930170013818 sequence-specific DNA binding site [nucleotide binding]; other site 930170013819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170013820 WHG domain; Region: WHG; pfam13305 930170013821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930170013822 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930170013823 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930170013824 active site 930170013825 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 930170013826 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930170013827 dimer interface [polypeptide binding]; other site 930170013828 active site 930170013829 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 930170013830 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 930170013831 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930170013832 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930170013833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930170013834 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 930170013835 substrate binding site [chemical binding]; other site 930170013836 oxyanion hole (OAH) forming residues; other site 930170013837 YuzL-like protein; Region: YuzL; pfam14115 930170013838 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170013839 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 930170013840 Proline dehydrogenase; Region: Pro_dh; cl03282 930170013841 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 930170013842 Domain of unknown function DUF77; Region: DUF77; pfam01910 930170013843 Cache domain; Region: Cache_1; pfam02743 930170013844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170013845 dimerization interface [polypeptide binding]; other site 930170013846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170013847 dimer interface [polypeptide binding]; other site 930170013848 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170013849 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170013850 dimer interface [polypeptide binding]; other site 930170013851 putative CheW interface [polypeptide binding]; other site 930170013852 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 930170013853 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170013854 Predicted transcriptional regulators [Transcription]; Region: COG1378 930170013855 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 930170013856 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 930170013857 C-terminal domain interface [polypeptide binding]; other site 930170013858 sugar binding site [chemical binding]; other site 930170013859 TQXA domain; Region: TQXA_dom; TIGR03934 930170013860 Cna protein B-type domain; Region: Cna_B; pfam05738 930170013861 Cna protein B-type domain; Region: Cna_B; pfam05738 930170013862 Cna protein B-type domain; Region: Cna_B; pfam05738 930170013863 Cna protein B-type domain; Region: Cna_B; pfam05738 930170013864 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930170013865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170013866 putative substrate translocation pore; other site 930170013867 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 930170013868 Spore germination protein; Region: Spore_permease; cl17796 930170013869 MAEBL; Provisional; Region: PTZ00121 930170013870 OxaA-like protein precursor; Validated; Region: PRK01622 930170013871 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930170013872 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170013873 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930170013874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930170013875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930170013876 hypothetical protein; Provisional; Region: PRK06758 930170013877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170013878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170013879 dimerization interface [polypeptide binding]; other site 930170013880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170013881 dimer interface [polypeptide binding]; other site 930170013882 phosphorylation site [posttranslational modification] 930170013883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013884 ATP binding site [chemical binding]; other site 930170013885 Mg2+ binding site [ion binding]; other site 930170013886 G-X-G motif; other site 930170013887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170013888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170013889 active site 930170013890 phosphorylation site [posttranslational modification] 930170013891 intermolecular recognition site; other site 930170013892 dimerization interface [polypeptide binding]; other site 930170013893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170013894 DNA binding site [nucleotide binding] 930170013895 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930170013896 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170013897 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 930170013898 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 930170013899 Walker A/P-loop; other site 930170013900 ATP binding site [chemical binding]; other site 930170013901 Q-loop/lid; other site 930170013902 ABC transporter signature motif; other site 930170013903 Walker B; other site 930170013904 D-loop; other site 930170013905 H-loop/switch region; other site 930170013906 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 930170013907 active site 930170013908 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 930170013909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170013910 non-specific DNA binding site [nucleotide binding]; other site 930170013911 salt bridge; other site 930170013912 sequence-specific DNA binding site [nucleotide binding]; other site 930170013913 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930170013914 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930170013915 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 930170013916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 930170013917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 930170013918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170013919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170013920 active site 930170013921 phosphorylation site [posttranslational modification] 930170013922 intermolecular recognition site; other site 930170013923 dimerization interface [polypeptide binding]; other site 930170013924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170013925 DNA binding site [nucleotide binding] 930170013926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170013927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170013928 dimer interface [polypeptide binding]; other site 930170013929 phosphorylation site [posttranslational modification] 930170013930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170013931 ATP binding site [chemical binding]; other site 930170013932 Mg2+ binding site [ion binding]; other site 930170013933 G-X-G motif; other site 930170013934 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930170013935 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 930170013936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170013937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170013938 dimerization interface [polypeptide binding]; other site 930170013939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170013940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170013941 dimer interface [polypeptide binding]; other site 930170013942 putative CheW interface [polypeptide binding]; other site 930170013943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170013944 dimerization interface [polypeptide binding]; other site 930170013945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170013946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170013947 dimer interface [polypeptide binding]; other site 930170013948 putative CheW interface [polypeptide binding]; other site 930170013949 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 930170013950 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930170013951 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930170013952 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930170013953 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930170013954 active site 930170013955 Zn binding site [ion binding]; other site 930170013956 Pirin-related protein [General function prediction only]; Region: COG1741 930170013957 Pirin; Region: Pirin; pfam02678 930170013958 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930170013959 MarR family; Region: MarR_2; pfam12802 930170013960 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 930170013961 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930170013962 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930170013963 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 930170013964 TrkA-C domain; Region: TrkA_C; pfam02080 930170013965 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170013966 amino acid carrier protein; Region: agcS; TIGR00835 930170013967 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 930170013968 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 930170013969 dimerization interface [polypeptide binding]; other site 930170013970 DPS ferroxidase diiron center [ion binding]; other site 930170013971 ion pore; other site 930170013972 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 930170013973 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 930170013974 metal binding site [ion binding]; metal-binding site 930170013975 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 930170013976 Ferritin-like domain; Region: Ferritin; pfam00210 930170013977 ferroxidase diiron center [ion binding]; other site 930170013978 Predicted membrane protein [Function unknown]; Region: COG2311 930170013979 Protein of unknown function (DUF418); Region: DUF418; cl12135 930170013980 Protein of unknown function (DUF418); Region: DUF418; pfam04235 930170013981 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170013982 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170013983 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170013984 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170013985 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170013986 Nucleoside recognition; Region: Gate; pfam07670 930170013987 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170013988 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170013989 amino acid carrier protein; Region: agcS; TIGR00835 930170013990 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930170013991 amino acid carrier protein; Region: agcS; TIGR00835 930170013992 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 930170013993 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930170013994 NAD binding site [chemical binding]; other site 930170013995 substrate binding site [chemical binding]; other site 930170013996 putative active site [active] 930170013997 Peptidase M60-like family; Region: M60-like; pfam13402 930170013998 TQXA domain; Region: TQXA_dom; TIGR03934 930170013999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930170014000 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930170014001 active site 930170014002 catalytic tetrad [active] 930170014003 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930170014004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170014005 putative substrate translocation pore; other site 930170014006 Predicted transcriptional regulators [Transcription]; Region: COG1733 930170014007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170014008 dimerization interface [polypeptide binding]; other site 930170014009 putative DNA binding site [nucleotide binding]; other site 930170014010 putative Zn2+ binding site [ion binding]; other site 930170014011 Uncharacterized conserved protein [Function unknown]; Region: COG2427 930170014012 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930170014013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170014014 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 930170014015 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 930170014016 active site 930170014017 HIGH motif; other site 930170014018 dimer interface [polypeptide binding]; other site 930170014019 KMSKS motif; other site 930170014020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930170014021 RNA binding surface [nucleotide binding]; other site 930170014022 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 930170014023 FAD binding domain; Region: FAD_binding_4; pfam01565 930170014024 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 930170014025 SET domain; Region: SET; pfam00856 930170014026 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 930170014027 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170014028 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170014029 dimer interface [polypeptide binding]; other site 930170014030 putative CheW interface [polypeptide binding]; other site 930170014031 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 930170014032 putative phosphate binding site [ion binding]; other site 930170014033 camphor resistance protein CrcB; Provisional; Region: PRK14219 930170014034 camphor resistance protein CrcB; Provisional; Region: PRK14205 930170014035 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 930170014036 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 930170014037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170014038 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170014039 putative substrate translocation pore; other site 930170014040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170014041 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170014042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170014043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170014044 ABC transporter; Region: ABC_tran_2; pfam12848 930170014045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170014046 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170014047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930170014048 Coenzyme A binding pocket [chemical binding]; other site 930170014049 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170014050 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930170014051 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 930170014052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170014053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170014054 putative substrate translocation pore; other site 930170014055 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 930170014056 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 930170014057 Nuclease-related domain; Region: NERD; pfam08378 930170014058 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 930170014059 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930170014060 Walker A/P-loop; other site 930170014061 ATP binding site [chemical binding]; other site 930170014062 Q-loop/lid; other site 930170014063 ABC transporter signature motif; other site 930170014064 Walker B; other site 930170014065 D-loop; other site 930170014066 H-loop/switch region; other site 930170014067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170014068 ABC-ATPase subunit interface; other site 930170014069 dimer interface [polypeptide binding]; other site 930170014070 putative PBP binding regions; other site 930170014071 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170014072 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170014073 ABC-ATPase subunit interface; other site 930170014074 dimer interface [polypeptide binding]; other site 930170014075 putative PBP binding regions; other site 930170014076 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 930170014077 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930170014078 intersubunit interface [polypeptide binding]; other site 930170014079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170014080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170014081 active site 930170014082 phosphorylation site [posttranslational modification] 930170014083 intermolecular recognition site; other site 930170014084 dimerization interface [polypeptide binding]; other site 930170014085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170014086 DNA binding site [nucleotide binding] 930170014087 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 930170014088 SmpB-tmRNA interface; other site 930170014089 ribonuclease R; Region: RNase_R; TIGR02063 930170014090 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 930170014091 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930170014092 RNB domain; Region: RNB; pfam00773 930170014093 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 930170014094 RNA binding site [nucleotide binding]; other site 930170014095 Esterase/lipase [General function prediction only]; Region: COG1647 930170014096 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 930170014097 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 930170014098 holin-like protein; Validated; Region: PRK01658 930170014099 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 930170014100 active site 930170014101 enolase; Provisional; Region: eno; PRK00077 930170014102 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 930170014103 dimer interface [polypeptide binding]; other site 930170014104 metal binding site [ion binding]; metal-binding site 930170014105 substrate binding pocket [chemical binding]; other site 930170014106 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 930170014107 phosphoglyceromutase; Provisional; Region: PRK05434 930170014108 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930170014109 triosephosphate isomerase; Provisional; Region: PRK14565 930170014110 substrate binding site [chemical binding]; other site 930170014111 dimer interface [polypeptide binding]; other site 930170014112 catalytic triad [active] 930170014113 Phosphoglycerate kinase; Region: PGK; pfam00162 930170014114 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 930170014115 substrate binding site [chemical binding]; other site 930170014116 hinge regions; other site 930170014117 ADP binding site [chemical binding]; other site 930170014118 catalytic site [active] 930170014119 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 930170014120 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 930170014121 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930170014122 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930170014123 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930170014124 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 930170014125 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 930170014126 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 930170014127 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 930170014128 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 930170014129 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 930170014130 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 930170014131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170014132 TPR motif; other site 930170014133 binding surface 930170014134 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170014135 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 930170014136 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 930170014137 stage V sporulation protein AD; Provisional; Region: PRK12404 930170014138 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 930170014139 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 930170014140 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 930170014141 Predicted membrane protein [Function unknown]; Region: COG2323 930170014142 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 930170014143 Clp protease; Region: CLP_protease; pfam00574 930170014144 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930170014145 oligomer interface [polypeptide binding]; other site 930170014146 active site residues [active] 930170014147 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930170014148 dimerization domain swap beta strand [polypeptide binding]; other site 930170014149 regulatory protein interface [polypeptide binding]; other site 930170014150 active site 930170014151 regulatory phosphorylation site [posttranslational modification]; other site 930170014152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 930170014153 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 930170014154 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 930170014155 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 930170014156 phosphate binding site [ion binding]; other site 930170014157 putative substrate binding pocket [chemical binding]; other site 930170014158 dimer interface [polypeptide binding]; other site 930170014159 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 930170014160 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 930170014161 putative active site [active] 930170014162 nucleotide binding site [chemical binding]; other site 930170014163 nudix motif; other site 930170014164 putative metal binding site [ion binding]; other site 930170014165 Domain of unknown function (DUF368); Region: DUF368; pfam04018 930170014166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170014167 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930170014168 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 930170014169 dimer interface [polypeptide binding]; other site 930170014170 active site 930170014171 CoA binding pocket [chemical binding]; other site 930170014172 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 930170014173 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930170014174 PYR/PP interface [polypeptide binding]; other site 930170014175 dimer interface [polypeptide binding]; other site 930170014176 TPP binding site [chemical binding]; other site 930170014177 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930170014178 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 930170014179 TPP-binding site [chemical binding]; other site 930170014180 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930170014181 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 930170014182 catalytic residues [active] 930170014183 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 930170014184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170014185 acyl-activating enzyme (AAE) consensus motif; other site 930170014186 AMP binding site [chemical binding]; other site 930170014187 active site 930170014188 CoA binding site [chemical binding]; other site 930170014189 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 930170014190 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 930170014191 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 930170014192 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 930170014193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170014194 NAD(P) binding site [chemical binding]; other site 930170014195 active site 930170014196 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930170014197 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170014198 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170014199 putative active site [active] 930170014200 putative NTP binding site [chemical binding]; other site 930170014201 putative nucleic acid binding site [nucleotide binding]; other site 930170014202 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170014203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170014204 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 930170014205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170014206 DNA binding residues [nucleotide binding] 930170014207 dimerization interface [polypeptide binding]; other site 930170014208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170014209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170014210 non-specific DNA binding site [nucleotide binding]; other site 930170014211 salt bridge; other site 930170014212 sequence-specific DNA binding site [nucleotide binding]; other site 930170014213 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 930170014214 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 930170014215 tetramer interface [polypeptide binding]; other site 930170014216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170014217 catalytic residue [active] 930170014218 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 930170014219 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 930170014220 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930170014221 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930170014222 dimer interface [polypeptide binding]; other site 930170014223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170014224 catalytic residue [active] 930170014225 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 930170014226 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930170014227 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 930170014228 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 930170014229 tetramer interface [polypeptide binding]; other site 930170014230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930170014231 CoA binding site [chemical binding]; other site 930170014232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170014233 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 930170014234 Condensation domain; Region: Condensation; pfam00668 930170014235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 930170014236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 930170014237 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170014238 acyl-activating enzyme (AAE) consensus motif; other site 930170014239 AMP binding site [chemical binding]; other site 930170014240 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170014241 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 930170014242 acyl-activating enzyme (AAE) consensus motif; other site 930170014243 AMP binding site [chemical binding]; other site 930170014244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170014245 Condensation domain; Region: Condensation; pfam00668 930170014246 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 930170014247 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 930170014248 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170014249 acyl-activating enzyme (AAE) consensus motif; other site 930170014250 AMP binding site [chemical binding]; other site 930170014251 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170014252 Condensation domain; Region: Condensation; pfam00668 930170014253 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 930170014254 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 930170014255 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 930170014256 acyl-activating enzyme (AAE) consensus motif; other site 930170014257 AMP binding site [chemical binding]; other site 930170014258 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930170014259 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 930170014260 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930170014261 dimer interface [polypeptide binding]; other site 930170014262 active site 930170014263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170014264 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930170014265 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930170014266 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930170014267 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 930170014268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170014269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170014270 Walker A/P-loop; other site 930170014271 ATP binding site [chemical binding]; other site 930170014272 Q-loop/lid; other site 930170014273 ABC transporter signature motif; other site 930170014274 Walker B; other site 930170014275 D-loop; other site 930170014276 H-loop/switch region; other site 930170014277 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 930170014278 FtsX-like permease family; Region: FtsX; pfam02687 930170014279 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 930170014280 FtsX-like permease family; Region: FtsX; pfam02687 930170014281 Predicted transcriptional regulators [Transcription]; Region: COG1695 930170014282 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930170014283 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 930170014284 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 930170014285 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930170014286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170014287 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 930170014288 dimer interface [polypeptide binding]; other site 930170014289 substrate binding site [chemical binding]; other site 930170014290 metal binding site [ion binding]; metal-binding site 930170014291 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170014292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170014293 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 930170014294 Protein export membrane protein; Region: SecD_SecF; cl14618 930170014295 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 930170014296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930170014297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930170014298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170014299 binding surface 930170014300 TPR motif; other site 930170014301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170014302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170014303 binding surface 930170014304 Tetratricopeptide repeat; Region: TPR_16; pfam13432 930170014305 TPR motif; other site 930170014306 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 930170014307 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 930170014308 trimer interface [polypeptide binding]; other site 930170014309 active site 930170014310 substrate binding site [chemical binding]; other site 930170014311 CoA binding site [chemical binding]; other site 930170014312 pyrophosphatase PpaX; Provisional; Region: PRK13288 930170014313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170014314 active site 930170014315 motif I; other site 930170014316 motif II; other site 930170014317 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 930170014318 HPr kinase/phosphorylase; Provisional; Region: PRK05428 930170014319 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 930170014320 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 930170014321 Hpr binding site; other site 930170014322 active site 930170014323 homohexamer subunit interaction site [polypeptide binding]; other site 930170014324 Predicted membrane protein [Function unknown]; Region: COG1950 930170014325 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 930170014326 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 930170014327 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930170014328 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930170014329 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 930170014330 excinuclease ABC subunit B; Provisional; Region: PRK05298 930170014331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170014332 ATP binding site [chemical binding]; other site 930170014333 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170014334 nucleotide binding region [chemical binding]; other site 930170014335 ATP-binding site [chemical binding]; other site 930170014336 Ultra-violet resistance protein B; Region: UvrB; pfam12344 930170014337 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 930170014338 potential frameshift: common BLAST hit: gi|52140397|ref|YP_086433.1| MerR family transcriptional regulator 930170014339 potential frameshift: common BLAST hit: gi|218906342|ref|YP_002454176.1| transcriptional regulator, MerR family 930170014340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170014341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170014342 non-specific DNA binding site [nucleotide binding]; other site 930170014343 salt bridge; other site 930170014344 sequence-specific DNA binding site [nucleotide binding]; other site 930170014345 Predicted membrane protein [Function unknown]; Region: COG2855 930170014346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170014347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170014348 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 930170014349 putative dimerization interface [polypeptide binding]; other site 930170014350 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 930170014351 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170014352 DNA binding residues [nucleotide binding] 930170014353 putative dimer interface [polypeptide binding]; other site 930170014354 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 930170014355 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930170014356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170014357 hypothetical protein; Provisional; Region: PRK12855 930170014358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930170014359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930170014360 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930170014361 Walker A/P-loop; other site 930170014362 ATP binding site [chemical binding]; other site 930170014363 Q-loop/lid; other site 930170014364 ABC transporter signature motif; other site 930170014365 Walker B; other site 930170014366 D-loop; other site 930170014367 H-loop/switch region; other site 930170014368 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930170014369 protein binding site [polypeptide binding]; other site 930170014370 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 930170014371 C-terminal peptidase (prc); Region: prc; TIGR00225 930170014372 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 930170014373 protein binding site [polypeptide binding]; other site 930170014374 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 930170014375 Catalytic dyad [active] 930170014376 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 930170014377 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 930170014378 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 930170014379 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 930170014380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170014381 Walker A/P-loop; other site 930170014382 ATP binding site [chemical binding]; other site 930170014383 Q-loop/lid; other site 930170014384 ABC transporter signature motif; other site 930170014385 Walker B; other site 930170014386 D-loop; other site 930170014387 H-loop/switch region; other site 930170014388 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 930170014389 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 930170014390 potential frameshift: common BLAST hit: gi|218906362|ref|YP_002454196.1| peptide chain release factor 2 930170014391 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 930170014392 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930170014393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 930170014394 nucleotide binding region [chemical binding]; other site 930170014395 ATP-binding site [chemical binding]; other site 930170014396 SEC-C motif; Region: SEC-C; pfam02810 930170014397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170014398 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 930170014399 Walker A/P-loop; other site 930170014400 ATP binding site [chemical binding]; other site 930170014401 Q-loop/lid; other site 930170014402 ABC transporter signature motif; other site 930170014403 Walker B; other site 930170014404 D-loop; other site 930170014405 H-loop/switch region; other site 930170014406 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 930170014407 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 930170014408 30S subunit binding site; other site 930170014409 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930170014410 DNA-binding site [nucleotide binding]; DNA binding site 930170014411 RNA-binding motif; other site 930170014412 comF family protein; Region: comF; TIGR00201 930170014413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170014414 active site 930170014415 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 930170014416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170014417 ATP binding site [chemical binding]; other site 930170014418 putative Mg++ binding site [ion binding]; other site 930170014419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170014420 nucleotide binding region [chemical binding]; other site 930170014421 ATP-binding site [chemical binding]; other site 930170014422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 930170014423 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930170014424 NlpC/P60 family; Region: NLPC_P60; pfam00877 930170014425 Predicted transcriptional regulators [Transcription]; Region: COG1733 930170014426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170014427 dimerization interface [polypeptide binding]; other site 930170014428 putative DNA binding site [nucleotide binding]; other site 930170014429 putative Zn2+ binding site [ion binding]; other site 930170014430 EDD domain protein, DegV family; Region: DegV; TIGR00762 930170014431 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930170014432 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 930170014433 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 930170014434 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 930170014435 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930170014436 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 930170014437 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 930170014438 active site 930170014439 homodimer interface [polypeptide binding]; other site 930170014440 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 930170014441 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 930170014442 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 930170014443 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 930170014444 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 930170014445 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 930170014446 Mg++ binding site [ion binding]; other site 930170014447 putative catalytic motif [active] 930170014448 substrate binding site [chemical binding]; other site 930170014449 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930170014450 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 930170014451 NodB motif; other site 930170014452 active site 930170014453 catalytic site [active] 930170014454 Zn binding site [ion binding]; other site 930170014455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170014456 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930170014457 Walker A motif; other site 930170014458 ATP binding site [chemical binding]; other site 930170014459 Walker B motif; other site 930170014460 arginine finger; other site 930170014461 Transcriptional antiterminator [Transcription]; Region: COG3933 930170014462 PRD domain; Region: PRD; pfam00874 930170014463 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930170014464 active pocket/dimerization site; other site 930170014465 active site 930170014466 phosphorylation site [posttranslational modification] 930170014467 PRD domain; Region: PRD; pfam00874 930170014468 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 930170014469 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 930170014470 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 930170014471 Chromate transporter; Region: Chromate_transp; pfam02417 930170014472 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 930170014473 putative active site [active] 930170014474 YdjC motif; other site 930170014475 Mg binding site [ion binding]; other site 930170014476 putative homodimer interface [polypeptide binding]; other site 930170014477 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 930170014478 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 930170014479 NAD binding site [chemical binding]; other site 930170014480 sugar binding site [chemical binding]; other site 930170014481 divalent metal binding site [ion binding]; other site 930170014482 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170014483 dimer interface [polypeptide binding]; other site 930170014484 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930170014485 active site 930170014486 methionine cluster; other site 930170014487 phosphorylation site [posttranslational modification] 930170014488 metal binding site [ion binding]; metal-binding site 930170014489 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930170014490 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930170014491 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930170014492 active site 930170014493 P-loop; other site 930170014494 phosphorylation site [posttranslational modification] 930170014495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170014496 S-adenosylmethionine binding site [chemical binding]; other site 930170014497 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 930170014498 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930170014499 methionine cluster; other site 930170014500 active site 930170014501 phosphorylation site [posttranslational modification] 930170014502 metal binding site [ion binding]; metal-binding site 930170014503 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930170014504 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 930170014505 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930170014506 active site 930170014507 P-loop; other site 930170014508 phosphorylation site [posttranslational modification] 930170014509 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 930170014510 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930170014511 Acyltransferase family; Region: Acyl_transf_3; pfam01757 930170014512 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 930170014513 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930170014514 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930170014515 Predicted membrane protein [Function unknown]; Region: COG1511 930170014516 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930170014517 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930170014518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930170014519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930170014520 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930170014521 putative dimerization interface [polypeptide binding]; other site 930170014522 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 930170014523 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 930170014524 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 930170014525 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 930170014526 transmembrane helices; other site 930170014527 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 930170014528 ThiC-associated domain; Region: ThiC-associated; pfam13667 930170014529 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 930170014530 L-lactate permease; Region: Lactate_perm; cl00701 930170014531 glycolate transporter; Provisional; Region: PRK09695 930170014532 Tic20-like protein; Region: Tic20; pfam09685 930170014533 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 930170014534 Uncharacterized conserved protein [Function unknown]; Region: COG3339 930170014535 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930170014536 Sulfatase; Region: Sulfatase; pfam00884 930170014537 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930170014538 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 930170014539 homodimer interface [polypeptide binding]; other site 930170014540 substrate-cofactor binding pocket; other site 930170014541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170014542 catalytic residue [active] 930170014543 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014544 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014545 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014546 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014547 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930170014549 NlpC/P60 family; Region: NLPC_P60; pfam00877 930170014550 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 930170014551 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 930170014552 Nucleoside recognition; Region: Gate; pfam07670 930170014553 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 930170014554 rod shape-determining protein MreC; Provisional; Region: PRK13922 930170014555 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 930170014556 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 930170014557 DXD motif; other site 930170014558 BCCT family transporter; Region: BCCT; pfam02028 930170014559 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014560 Bacterial SH3 domain; Region: SH3_3; pfam08239 930170014561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930170014562 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 930170014563 Predicted membrane protein [Function unknown]; Region: COG4640 930170014564 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 930170014565 Double zinc ribbon; Region: DZR; pfam12773 930170014566 Double zinc ribbon; Region: DZR; pfam12773 930170014567 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 930170014568 SNF2 Helicase protein; Region: DUF3670; pfam12419 930170014569 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 930170014570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930170014571 ATP binding site [chemical binding]; other site 930170014572 putative Mg++ binding site [ion binding]; other site 930170014573 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 930170014574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170014575 nucleotide binding region [chemical binding]; other site 930170014576 ATP-binding site [chemical binding]; other site 930170014577 Predicted integral membrane protein [Function unknown]; Region: COG5652 930170014578 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 930170014579 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 930170014580 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 930170014581 ComK protein; Region: ComK; pfam06338 930170014582 RNA polymerase factor sigma-70; Validated; Region: PRK06759 930170014583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170014584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170014585 DNA binding residues [nucleotide binding] 930170014586 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 930170014587 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930170014588 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930170014589 FtsX-like permease family; Region: FtsX; pfam02687 930170014590 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930170014591 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930170014592 Walker A/P-loop; other site 930170014593 ATP binding site [chemical binding]; other site 930170014594 Q-loop/lid; other site 930170014595 ABC transporter signature motif; other site 930170014596 Walker B; other site 930170014597 D-loop; other site 930170014598 H-loop/switch region; other site 930170014599 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930170014600 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 930170014601 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930170014602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170014603 non-specific DNA binding site [nucleotide binding]; other site 930170014604 salt bridge; other site 930170014605 sequence-specific DNA binding site [nucleotide binding]; other site 930170014606 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 930170014607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170014608 putative substrate translocation pore; other site 930170014609 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 930170014610 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 930170014611 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 930170014612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930170014613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170014614 dimerization interface [polypeptide binding]; other site 930170014615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170014616 dimer interface [polypeptide binding]; other site 930170014617 phosphorylation site [posttranslational modification] 930170014618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170014619 ATP binding site [chemical binding]; other site 930170014620 Mg2+ binding site [ion binding]; other site 930170014621 G-X-G motif; other site 930170014622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170014623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170014624 active site 930170014625 phosphorylation site [posttranslational modification] 930170014626 intermolecular recognition site; other site 930170014627 dimerization interface [polypeptide binding]; other site 930170014628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170014629 DNA binding site [nucleotide binding] 930170014630 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 930170014631 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 930170014632 NAD binding site [chemical binding]; other site 930170014633 homodimer interface [polypeptide binding]; other site 930170014634 active site 930170014635 substrate binding site [chemical binding]; other site 930170014636 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 930170014637 active site 930170014638 catalytic triad [active] 930170014639 oxyanion hole [active] 930170014640 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 930170014641 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 930170014642 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 930170014643 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 930170014644 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 930170014645 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930170014646 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 930170014647 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 930170014648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930170014649 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 930170014650 putative ADP-binding pocket [chemical binding]; other site 930170014651 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170014652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930170014653 active site 930170014654 Bacterial sugar transferase; Region: Bac_transf; pfam02397 930170014655 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 930170014656 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 930170014657 inhibitor-cofactor binding pocket; inhibition site 930170014658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170014659 catalytic residue [active] 930170014660 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 930170014661 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930170014662 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 930170014663 NAD(P) binding site [chemical binding]; other site 930170014664 homodimer interface [polypeptide binding]; other site 930170014665 substrate binding site [chemical binding]; other site 930170014666 active site 930170014667 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 930170014668 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930170014669 active site 930170014670 tetramer interface; other site 930170014671 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 930170014672 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 930170014673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930170014674 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 930170014675 Chain length determinant protein; Region: Wzz; cl15801 930170014676 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 930170014677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930170014678 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 930170014679 rod shape-determining protein Mbl; Provisional; Region: PRK13928 930170014680 MreB and similar proteins; Region: MreB_like; cd10225 930170014681 nucleotide binding site [chemical binding]; other site 930170014682 Mg binding site [ion binding]; other site 930170014683 putative protofilament interaction site [polypeptide binding]; other site 930170014684 RodZ interaction site [polypeptide binding]; other site 930170014685 Stage III sporulation protein D; Region: SpoIIID; pfam12116 930170014686 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930170014687 Peptidase family M23; Region: Peptidase_M23; pfam01551 930170014688 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930170014689 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930170014690 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170014691 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170014692 Walker A/P-loop; other site 930170014693 ATP binding site [chemical binding]; other site 930170014694 Q-loop/lid; other site 930170014695 ABC transporter signature motif; other site 930170014696 Walker B; other site 930170014697 D-loop; other site 930170014698 H-loop/switch region; other site 930170014699 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930170014700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170014701 Walker A/P-loop; other site 930170014702 ATP binding site [chemical binding]; other site 930170014703 Q-loop/lid; other site 930170014704 ABC transporter signature motif; other site 930170014705 Walker B; other site 930170014706 D-loop; other site 930170014707 H-loop/switch region; other site 930170014708 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930170014709 LytTr DNA-binding domain; Region: LytTR; pfam04397 930170014710 Stage II sporulation protein; Region: SpoIID; pfam08486 930170014711 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 930170014712 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930170014713 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930170014714 hinge; other site 930170014715 active site 930170014716 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 930170014717 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 930170014718 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 930170014719 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930170014720 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 930170014721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930170014722 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 930170014723 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 930170014724 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930170014725 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 930170014726 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 930170014727 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 930170014728 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 930170014729 4Fe-4S binding domain; Region: Fer4; cl02805 930170014730 4Fe-4S binding domain; Region: Fer4; pfam00037 930170014731 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 930170014732 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 930170014733 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 930170014734 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 930170014735 NADH dehydrogenase subunit C; Validated; Region: PRK07735 930170014736 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 930170014737 NADH dehydrogenase subunit B; Validated; Region: PRK06411 930170014738 NADH dehydrogenase subunit A; Validated; Region: PRK07756 930170014739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170014740 PAS domain; Region: PAS_9; pfam13426 930170014741 putative active site [active] 930170014742 heme pocket [chemical binding]; other site 930170014743 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170014744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170014745 metal binding site [ion binding]; metal-binding site 930170014746 active site 930170014747 I-site; other site 930170014748 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170014749 Protein of unknown function (DUF975); Region: DUF975; cl10504 930170014750 Protein of unknown function (DUF975); Region: DUF975; cl10504 930170014751 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 930170014752 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 930170014753 gamma subunit interface [polypeptide binding]; other site 930170014754 epsilon subunit interface [polypeptide binding]; other site 930170014755 LBP interface [polypeptide binding]; other site 930170014756 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 930170014757 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930170014758 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 930170014759 alpha subunit interaction interface [polypeptide binding]; other site 930170014760 Walker A motif; other site 930170014761 ATP binding site [chemical binding]; other site 930170014762 Walker B motif; other site 930170014763 inhibitor binding site; inhibition site 930170014764 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930170014765 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 930170014766 core domain interface [polypeptide binding]; other site 930170014767 delta subunit interface [polypeptide binding]; other site 930170014768 epsilon subunit interface [polypeptide binding]; other site 930170014769 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 930170014770 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930170014771 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 930170014772 beta subunit interaction interface [polypeptide binding]; other site 930170014773 Walker A motif; other site 930170014774 ATP binding site [chemical binding]; other site 930170014775 Walker B motif; other site 930170014776 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930170014777 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 930170014778 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 930170014779 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 930170014780 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 930170014781 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 930170014782 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 930170014783 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 930170014784 ATP synthase I chain; Region: ATP_synt_I; pfam03899 930170014785 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 930170014786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930170014787 active site 930170014788 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 930170014789 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 930170014790 dimer interface [polypeptide binding]; other site 930170014791 active site 930170014792 glycine-pyridoxal phosphate binding site [chemical binding]; other site 930170014793 folate binding site [chemical binding]; other site 930170014794 hypothetical protein; Provisional; Region: PRK13690 930170014795 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 930170014796 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930170014797 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930170014798 active site 930170014799 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930170014800 HPr interaction site; other site 930170014801 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930170014802 active site 930170014803 phosphorylation site [posttranslational modification] 930170014804 Predicted membrane protein [Function unknown]; Region: COG2259 930170014805 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 930170014806 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 930170014807 oligomer interface [polypeptide binding]; other site 930170014808 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 930170014809 Predicted membrane protein [Function unknown]; Region: COG1971 930170014810 Domain of unknown function DUF; Region: DUF204; pfam02659 930170014811 Domain of unknown function DUF; Region: DUF204; pfam02659 930170014812 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 930170014813 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 930170014814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930170014815 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 930170014816 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 930170014817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170014818 S-adenosylmethionine binding site [chemical binding]; other site 930170014819 peptide chain release factor 1; Validated; Region: prfA; PRK00591 930170014820 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930170014821 RF-1 domain; Region: RF-1; pfam00472 930170014822 thymidine kinase; Provisional; Region: PRK04296 930170014823 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 930170014824 transcription termination factor Rho; Provisional; Region: rho; PRK09376 930170014825 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 930170014826 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 930170014827 RNA binding site [nucleotide binding]; other site 930170014828 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 930170014829 multimer interface [polypeptide binding]; other site 930170014830 Walker A motif; other site 930170014831 ATP binding site [chemical binding]; other site 930170014832 Walker B motif; other site 930170014833 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 930170014834 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 930170014835 putative active site [active] 930170014836 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930170014837 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930170014838 hinge; other site 930170014839 active site 930170014840 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 930170014841 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930170014842 intersubunit interface [polypeptide binding]; other site 930170014843 active site 930170014844 zinc binding site [ion binding]; other site 930170014845 Na+ binding site [ion binding]; other site 930170014846 Response regulator receiver domain; Region: Response_reg; pfam00072 930170014847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170014848 active site 930170014849 phosphorylation site [posttranslational modification] 930170014850 intermolecular recognition site; other site 930170014851 dimerization interface [polypeptide binding]; other site 930170014852 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 930170014853 CTP synthetase; Validated; Region: pyrG; PRK05380 930170014854 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 930170014855 Catalytic site [active] 930170014856 active site 930170014857 UTP binding site [chemical binding]; other site 930170014858 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 930170014859 active site 930170014860 putative oxyanion hole; other site 930170014861 catalytic triad [active] 930170014862 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 930170014863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170014864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170014865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930170014866 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 930170014867 FAD binding site [chemical binding]; other site 930170014868 homotetramer interface [polypeptide binding]; other site 930170014869 substrate binding pocket [chemical binding]; other site 930170014870 catalytic base [active] 930170014871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930170014872 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 930170014873 FAD binding site [chemical binding]; other site 930170014874 homotetramer interface [polypeptide binding]; other site 930170014875 substrate binding pocket [chemical binding]; other site 930170014876 catalytic base [active] 930170014877 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 930170014878 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 930170014879 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930170014880 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 930170014881 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930170014882 dimer interface [polypeptide binding]; other site 930170014883 active site 930170014884 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 930170014885 4Fe-4S binding domain; Region: Fer4; cl02805 930170014886 Cysteine-rich domain; Region: CCG; pfam02754 930170014887 Cysteine-rich domain; Region: CCG; pfam02754 930170014888 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930170014889 PLD-like domain; Region: PLDc_2; pfam13091 930170014890 putative active site [active] 930170014891 catalytic site [active] 930170014892 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930170014893 PLD-like domain; Region: PLDc_2; pfam13091 930170014894 putative active site [active] 930170014895 catalytic site [active] 930170014896 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 930170014897 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 930170014898 PAS domain S-box; Region: sensory_box; TIGR00229 930170014899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170014900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170014901 metal binding site [ion binding]; metal-binding site 930170014902 active site 930170014903 I-site; other site 930170014904 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930170014905 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 930170014906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170014907 non-specific DNA binding site [nucleotide binding]; other site 930170014908 salt bridge; other site 930170014909 sequence-specific DNA binding site [nucleotide binding]; other site 930170014910 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930170014911 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930170014912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170014913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170014914 active site 930170014915 phosphorylation site [posttranslational modification] 930170014916 intermolecular recognition site; other site 930170014917 dimerization interface [polypeptide binding]; other site 930170014918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170014919 DNA binding residues [nucleotide binding] 930170014920 dimerization interface [polypeptide binding]; other site 930170014921 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 930170014922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170014923 Histidine kinase; Region: HisKA_3; pfam07730 930170014924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170014925 ATP binding site [chemical binding]; other site 930170014926 Mg2+ binding site [ion binding]; other site 930170014927 G-X-G motif; other site 930170014928 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930170014929 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930170014930 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170014931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930170014932 Walker A/P-loop; other site 930170014933 ATP binding site [chemical binding]; other site 930170014934 Q-loop/lid; other site 930170014935 ABC transporter signature motif; other site 930170014936 Walker B; other site 930170014937 D-loop; other site 930170014938 H-loop/switch region; other site 930170014939 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930170014940 active site 930170014941 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930170014942 Collagen binding domain; Region: Collagen_bind; pfam05737 930170014943 Collagen binding domain; Region: Collagen_bind; pfam05737 930170014944 Collagen binding domain; Region: Collagen_bind; pfam05737 930170014945 Collagen binding domain; Region: Collagen_bind; pfam05737 930170014946 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014947 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014948 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014949 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014950 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014951 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014952 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014953 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930170014954 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014955 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014956 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014957 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014958 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930170014959 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014960 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014961 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014962 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014963 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014964 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930170014965 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014966 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014967 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014968 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014969 Cna protein B-type domain; Region: Cna_B; pfam05738 930170014970 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 930170014971 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 930170014972 PA/protease or protease-like domain interface [polypeptide binding]; other site 930170014973 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 930170014974 Peptidase family M28; Region: Peptidase_M28; pfam04389 930170014975 metal binding site [ion binding]; metal-binding site 930170014976 RNA polymerase sigma factor; Provisional; Region: PRK12522 930170014977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930170014978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930170014979 DNA binding residues [nucleotide binding] 930170014980 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 930170014981 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 930170014982 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 930170014983 active site 930170014984 HIGH motif; other site 930170014985 KMSK motif region; other site 930170014986 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 930170014987 tRNA binding surface [nucleotide binding]; other site 930170014988 anticodon binding site; other site 930170014989 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 930170014990 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930170014991 putative dimer interface [polypeptide binding]; other site 930170014992 catalytic triad [active] 930170014993 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 930170014994 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 930170014995 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 930170014996 agmatinase; Region: agmatinase; TIGR01230 930170014997 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 930170014998 putative active site [active] 930170014999 Mn binding site [ion binding]; other site 930170015000 spermidine synthase; Provisional; Region: PRK00811 930170015001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170015002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170015003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930170015004 putative substrate translocation pore; other site 930170015005 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930170015006 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 930170015007 DNA binding residues [nucleotide binding] 930170015008 putative dimer interface [polypeptide binding]; other site 930170015009 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930170015010 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 930170015011 active site 930170015012 catalytic site [active] 930170015013 metal binding site [ion binding]; metal-binding site 930170015014 dimer interface [polypeptide binding]; other site 930170015015 Transglycosylase; Region: Transgly; pfam00912 930170015016 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930170015017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930170015018 YwhD family; Region: YwhD; pfam08741 930170015019 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 930170015020 Peptidase family M50; Region: Peptidase_M50; pfam02163 930170015021 active site 930170015022 putative substrate binding region [chemical binding]; other site 930170015023 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 930170015024 active site 1 [active] 930170015025 dimer interface [polypeptide binding]; other site 930170015026 hexamer interface [polypeptide binding]; other site 930170015027 active site 2 [active] 930170015028 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 930170015029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930170015030 Zn2+ binding site [ion binding]; other site 930170015031 Mg2+ binding site [ion binding]; other site 930170015032 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930170015033 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930170015034 intersubunit interface [polypeptide binding]; other site 930170015035 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930170015036 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930170015037 Walker A/P-loop; other site 930170015038 ATP binding site [chemical binding]; other site 930170015039 Q-loop/lid; other site 930170015040 ABC transporter signature motif; other site 930170015041 Walker B; other site 930170015042 D-loop; other site 930170015043 H-loop/switch region; other site 930170015044 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170015045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170015046 ABC-ATPase subunit interface; other site 930170015047 dimer interface [polypeptide binding]; other site 930170015048 putative PBP binding regions; other site 930170015049 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930170015050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930170015051 ABC-ATPase subunit interface; other site 930170015052 dimer interface [polypeptide binding]; other site 930170015053 putative PBP binding regions; other site 930170015054 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 930170015055 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 930170015056 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 930170015057 hypothetical protein; Provisional; Region: PRK12473 930170015058 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930170015059 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 930170015060 putative heme peroxidase; Provisional; Region: PRK12276 930170015061 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 930170015062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930170015063 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 930170015064 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 930170015065 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 930170015066 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 930170015067 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 930170015068 Ion channel; Region: Ion_trans_2; pfam07885 930170015069 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930170015070 TrkA-N domain; Region: TrkA_N; pfam02254 930170015071 TrkA-C domain; Region: TrkA_C; pfam02080 930170015072 putative uracil/xanthine transporter; Provisional; Region: PRK11412 930170015073 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930170015074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170015075 motif II; other site 930170015076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170015077 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 930170015078 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 930170015079 ligand binding site [chemical binding]; other site 930170015080 active site 930170015081 UGI interface [polypeptide binding]; other site 930170015082 catalytic site [active] 930170015083 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 930170015084 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 930170015085 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930170015086 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930170015087 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 930170015088 Walker A/P-loop; other site 930170015089 ATP binding site [chemical binding]; other site 930170015090 Q-loop/lid; other site 930170015091 ABC transporter signature motif; other site 930170015092 Walker B; other site 930170015093 D-loop; other site 930170015094 H-loop/switch region; other site 930170015095 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 930170015096 active site 930170015097 catalytic triad [active] 930170015098 oxyanion hole [active] 930170015099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170015100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930170015101 DNA binding site [nucleotide binding] 930170015102 domain linker motif; other site 930170015103 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930170015104 putative dimerization interface [polypeptide binding]; other site 930170015105 putative ligand binding site [chemical binding]; other site 930170015106 Predicted membrane protein [Function unknown]; Region: COG2364 930170015107 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930170015108 homoserine dehydrogenase; Provisional; Region: PRK06349 930170015109 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 930170015110 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 930170015111 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 930170015112 Homoserine O-succinyltransferase; Region: HTS; pfam04204 930170015113 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 930170015114 proposed active site lysine [active] 930170015115 conserved cys residue [active] 930170015116 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 930170015117 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930170015118 homodimer interface [polypeptide binding]; other site 930170015119 substrate-cofactor binding pocket; other site 930170015120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930170015121 catalytic residue [active] 930170015122 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 930170015123 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 930170015124 Cl- selectivity filter; other site 930170015125 Cl- binding residues [ion binding]; other site 930170015126 pore gating glutamate residue; other site 930170015127 dimer interface [polypeptide binding]; other site 930170015128 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 930170015129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930170015130 active site 930170015131 motif I; other site 930170015132 motif II; other site 930170015133 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 930170015134 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930170015135 ligand binding site [chemical binding]; other site 930170015136 flexible hinge region; other site 930170015137 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 930170015138 azoreductase; Provisional; Region: PRK13556 930170015139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930170015140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170015141 active site 930170015142 phosphorylation site [posttranslational modification] 930170015143 intermolecular recognition site; other site 930170015144 dimerization interface [polypeptide binding]; other site 930170015145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930170015146 DNA binding residues [nucleotide binding] 930170015147 dimerization interface [polypeptide binding]; other site 930170015148 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930170015149 GAF domain; Region: GAF; pfam01590 930170015150 GAF domain; Region: GAF_3; pfam13492 930170015151 GAF domain; Region: GAF_2; pfam13185 930170015152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930170015153 Histidine kinase; Region: HisKA_3; pfam07730 930170015154 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 930170015155 ATP binding site [chemical binding]; other site 930170015156 Mg2+ binding site [ion binding]; other site 930170015157 G-X-G motif; other site 930170015158 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930170015159 dimer interface [polypeptide binding]; other site 930170015160 substrate binding site [chemical binding]; other site 930170015161 ATP binding site [chemical binding]; other site 930170015162 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930170015163 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930170015164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930170015165 metal binding site [ion binding]; metal-binding site 930170015166 active site 930170015167 I-site; other site 930170015168 Protein of unknown function (DUF466); Region: DUF466; pfam04328 930170015169 carbon starvation protein A; Provisional; Region: PRK15015 930170015170 Carbon starvation protein CstA; Region: CstA; pfam02554 930170015171 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 930170015172 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930170015173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170015174 active site 930170015175 phosphorylation site [posttranslational modification] 930170015176 intermolecular recognition site; other site 930170015177 dimerization interface [polypeptide binding]; other site 930170015178 LytTr DNA-binding domain; Region: LytTR; pfam04397 930170015179 benzoate transport; Region: 2A0115; TIGR00895 930170015180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170015181 putative substrate translocation pore; other site 930170015182 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 930170015183 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 930170015184 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930170015185 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 930170015186 Predicted membrane protein [Function unknown]; Region: COG2860 930170015187 UPF0126 domain; Region: UPF0126; pfam03458 930170015188 UPF0126 domain; Region: UPF0126; pfam03458 930170015189 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 930170015190 heme-binding site [chemical binding]; other site 930170015191 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 930170015192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930170015193 dimer interface [polypeptide binding]; other site 930170015194 putative CheW interface [polypeptide binding]; other site 930170015195 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 930170015196 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 930170015197 Fungal specific transcription factor domain; Region: Fungal_trans; cl04389 930170015198 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170015199 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 930170015200 Ligand binding site; other site 930170015201 Putative Catalytic site; other site 930170015202 DXD motif; other site 930170015203 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930170015204 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930170015205 active site 930170015206 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930170015207 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 930170015208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170015209 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930170015210 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170015211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170015212 ABC transporter; Region: ABC_tran_2; pfam12848 930170015213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930170015214 conserved hypothetical integral membrane protein; Region: TIGR03766 930170015215 Predicted membrane protein [Function unknown]; Region: COG2246 930170015216 GtrA-like protein; Region: GtrA; pfam04138 930170015217 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 930170015218 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 930170015219 Ligand binding site; other site 930170015220 Putative Catalytic site; other site 930170015221 DXD motif; other site 930170015222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930170015223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930170015224 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 930170015225 Protein export membrane protein; Region: SecD_SecF; cl14618 930170015226 methionine sulfoxide reductase A; Provisional; Region: PRK14054 930170015227 methionine sulfoxide reductase B; Provisional; Region: PRK00222 930170015228 SelR domain; Region: SelR; pfam01641 930170015229 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930170015230 antiholin-like protein LrgB; Provisional; Region: PRK04288 930170015231 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 930170015232 two-component response regulator; Provisional; Region: PRK14084 930170015233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170015234 active site 930170015235 phosphorylation site [posttranslational modification] 930170015236 intermolecular recognition site; other site 930170015237 dimerization interface [polypeptide binding]; other site 930170015238 LytTr DNA-binding domain; Region: LytTR; pfam04397 930170015239 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 930170015240 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930170015241 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930170015242 Histidine kinase; Region: His_kinase; pfam06580 930170015243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170015244 ATP binding site [chemical binding]; other site 930170015245 Mg2+ binding site [ion binding]; other site 930170015246 G-X-G motif; other site 930170015247 benzoate transport; Region: 2A0115; TIGR00895 930170015248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930170015249 putative substrate translocation pore; other site 930170015250 BCCT family transporter; Region: BCCT; pfam02028 930170015251 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 930170015252 active site 930170015253 dimer interface [polypeptide binding]; other site 930170015254 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 930170015255 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 930170015256 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 930170015257 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930170015258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930170015259 NAD(P) binding site [chemical binding]; other site 930170015260 active site 930170015261 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 930170015262 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 930170015263 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 930170015264 GAF domain; Region: GAF_3; pfam13492 930170015265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930170015266 binding surface 930170015267 TPR motif; other site 930170015268 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 930170015269 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 930170015270 NodB motif; other site 930170015271 putative active site [active] 930170015272 putative catalytic site [active] 930170015273 putative Zn binding site [ion binding]; other site 930170015274 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 930170015275 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930170015276 Predicted membrane protein [Function unknown]; Region: COG4267 930170015277 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 930170015278 UDP-glucose 4-epimerase; Region: PLN02240 930170015279 NAD binding site [chemical binding]; other site 930170015280 homodimer interface [polypeptide binding]; other site 930170015281 active site 930170015282 substrate binding site [chemical binding]; other site 930170015283 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 930170015284 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 930170015285 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 930170015286 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 930170015287 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930170015288 ATP binding site [chemical binding]; other site 930170015289 Mg++ binding site [ion binding]; other site 930170015290 motif III; other site 930170015291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170015292 nucleotide binding region [chemical binding]; other site 930170015293 ATP-binding site [chemical binding]; other site 930170015294 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 930170015295 RNA binding site [nucleotide binding]; other site 930170015296 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 930170015297 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930170015298 active site 930170015299 oligoendopeptidase F; Region: pepF; TIGR00181 930170015300 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 930170015301 active site 930170015302 Zn binding site [ion binding]; other site 930170015303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930170015304 FeS/SAM binding site; other site 930170015305 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 930170015306 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 930170015307 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 930170015308 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 930170015309 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930170015310 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930170015311 protein binding site [polypeptide binding]; other site 930170015312 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 930170015313 YycH protein; Region: YycI; pfam09648 930170015314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 930170015315 YycH protein; Region: YycH; pfam07435 930170015316 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 930170015317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 930170015318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930170015319 dimerization interface [polypeptide binding]; other site 930170015320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930170015321 putative active site [active] 930170015322 heme pocket [chemical binding]; other site 930170015323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930170015324 dimer interface [polypeptide binding]; other site 930170015325 phosphorylation site [posttranslational modification] 930170015326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930170015327 ATP binding site [chemical binding]; other site 930170015328 Mg2+ binding site [ion binding]; other site 930170015329 G-X-G motif; other site 930170015330 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930170015331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930170015332 active site 930170015333 phosphorylation site [posttranslational modification] 930170015334 intermolecular recognition site; other site 930170015335 dimerization interface [polypeptide binding]; other site 930170015336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930170015337 DNA binding site [nucleotide binding] 930170015338 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 930170015339 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 930170015340 GDP-binding site [chemical binding]; other site 930170015341 ACT binding site; other site 930170015342 IMP binding site; other site 930170015343 replicative DNA helicase; Provisional; Region: PRK05748 930170015344 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 930170015345 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 930170015346 Walker A motif; other site 930170015347 ATP binding site [chemical binding]; other site 930170015348 Walker B motif; other site 930170015349 DNA binding loops [nucleotide binding] 930170015350 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 930170015351 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 930170015352 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 930170015353 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 930170015354 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 930170015355 DHH family; Region: DHH; pfam01368 930170015356 DHHA1 domain; Region: DHHA1; pfam02272 930170015357 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 930170015358 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 930170015359 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930170015360 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930170015361 dimer interface [polypeptide binding]; other site 930170015362 ssDNA binding site [nucleotide binding]; other site 930170015363 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930170015364 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 930170015365 GTP-binding protein YchF; Reviewed; Region: PRK09601 930170015366 YchF GTPase; Region: YchF; cd01900 930170015367 G1 box; other site 930170015368 GTP/Mg2+ binding site [chemical binding]; other site 930170015369 Switch I region; other site 930170015370 G2 box; other site 930170015371 Switch II region; other site 930170015372 G3 box; other site 930170015373 G4 box; other site 930170015374 G5 box; other site 930170015375 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 930170015376 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 930170015377 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 930170015378 Mechanosensitive ion channel; Region: MS_channel; pfam00924 930170015379 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 930170015380 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 930170015381 ParB-like nuclease domain; Region: ParB; smart00470 930170015382 KorB domain; Region: KorB; pfam08535 930170015383 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930170015384 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930170015385 P-loop; other site 930170015386 Magnesium ion binding site [ion binding]; other site 930170015387 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930170015388 Magnesium ion binding site [ion binding]; other site 930170015389 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 930170015390 ParB-like nuclease domain; Region: ParBc; pfam02195 930170015391 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 930170015392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930170015393 S-adenosylmethionine binding site [chemical binding]; other site 930170015394 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 930170015395 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 930170015396 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 930170015397 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 930170015398 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 930170015399 trmE is a tRNA modification GTPase; Region: trmE; cd04164 930170015400 G1 box; other site 930170015401 GTP/Mg2+ binding site [chemical binding]; other site 930170015402 Switch I region; other site 930170015403 G2 box; other site 930170015404 Switch II region; other site 930170015405 G3 box; other site 930170015406 G4 box; other site 930170015407 G5 box; other site 930170015408 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 930170015409 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 930170015410 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 930170015411 G-X-X-G motif; other site 930170015412 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 930170015413 RxxxH motif; other site 930170015414 OxaA-like protein precursor; Validated; Region: PRK02944 930170015415 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 930170015416 ribonuclease P; Reviewed; Region: rnpA; PRK00499 930170015417 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 930170015418 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930170015419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930170015420 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930170015421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170015422 dimerization interface [polypeptide binding]; other site 930170015423 putative DNA binding site [nucleotide binding]; other site 930170015424 putative Zn2+ binding site [ion binding]; other site 930170015425 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930170015426 bacterial Hfq-like; Region: Hfq; cd01716 930170015427 hexamer interface [polypeptide binding]; other site 930170015428 Sm1 motif; other site 930170015429 RNA binding site [nucleotide binding]; other site 930170015430 Sm2 motif; other site 930170015431 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 930170015432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930170015433 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170015434 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170015435 potential frameshift: common BLAST hit: gi|161598654|ref|YP_001573869.1| insertion sequence IS240 protein 930170015436 potential frameshift: common BLAST hit: gi|163943265|ref|YP_001642495.1| Delta endotoxin central region subgroup 1 930170015437 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 930170015438 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 930170015439 delta endotoxin; Region: Endotoxin_M; pfam00555 930170015440 potential frameshift: common BLAST hit: gi|163943344|ref|YP_001642574.1| transposase IS4 family protein 930170015441 potential frameshift: common BLAST hit: gi|218234478|ref|YP_002369074.1| integrase core domain protein 930170015442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930170015443 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170015444 Helix-turn-helix domain; Region: HTH_28; pfam13518 930170015445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930170015446 Transposase; Region: HTH_Tnp_1; pfam01527 930170015447 Integrase core domain; Region: rve; pfam00665 930170015448 Integrase core domain; Region: rve_3; pfam13683 930170015449 H+ Antiporter protein; Region: 2A0121; TIGR00900 930170015450 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 930170015451 putative deacylase active site [active] 930170015452 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930170015453 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 930170015454 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 930170015455 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930170015456 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930170015457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170015458 Integrase core domain; Region: rve; pfam00665 930170015459 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 930170015460 Probable transposase; Region: OrfB_IS605; pfam01385 930170015461 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 930170015462 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 930170015463 Transposase IS200 like; Region: Y1_Tnp; pfam01797 930170015464 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 930170015465 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 930170015466 Helix-turn-helix domain; Region: HTH_17; pfam12728 930170015467 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 930170015468 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 930170015469 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 930170015470 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 930170015471 ATP binding site [chemical binding]; other site 930170015472 substrate interface [chemical binding]; other site 930170015473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170015474 Integrase core domain; Region: rve; pfam00665 930170015475 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 930170015476 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 930170015477 delta endotoxin; Region: Endotoxin_M; pfam00555 930170015478 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 930170015479 putative metal binding site [ion binding]; other site 930170015480 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170015481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170015482 Integrase core domain; Region: rve; pfam00665 930170015483 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 930170015484 Part of AAA domain; Region: AAA_19; pfam13245 930170015485 Family description; Region: UvrD_C_2; pfam13538 930170015486 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 930170015487 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 930170015488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170015489 Walker A motif; other site 930170015490 ATP binding site [chemical binding]; other site 930170015491 Walker B motif; other site 930170015492 arginine finger; other site 930170015493 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930170015494 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930170015495 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170015496 non-specific DNA binding site [nucleotide binding]; other site 930170015497 salt bridge; other site 930170015498 sequence-specific DNA binding site [nucleotide binding]; other site 930170015499 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 930170015500 putative active site [active] 930170015501 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930170015502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930170015503 nucleotide binding region [chemical binding]; other site 930170015504 ATP-binding site [chemical binding]; other site 930170015505 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930170015506 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 930170015507 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 930170015508 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 930170015509 Methyltransferase domain; Region: Methyltransf_26; pfam13659 930170015510 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 930170015511 GIY-YIG motif/motif A; other site 930170015512 putative active site [active] 930170015513 putative metal binding site [ion binding]; other site 930170015514 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 930170015515 putative catalytic site [active] 930170015516 putative phosphate binding site [ion binding]; other site 930170015517 putative metal binding site [ion binding]; other site 930170015518 Helix-turn-helix domain; Region: HTH_17; pfam12728 930170015519 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 930170015520 MPN+ (JAMM) motif; other site 930170015521 Zinc-binding site [ion binding]; other site 930170015522 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930170015523 RNA binding site [nucleotide binding]; other site 930170015524 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930170015525 RNA binding site [nucleotide binding]; other site 930170015526 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930170015527 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930170015528 catalytic residue [active] 930170015529 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930170015530 NlpC/P60 family; Region: NLPC_P60; pfam00877 930170015531 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 930170015532 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 930170015533 Herpesvirus ICP4-like protein N-terminal region; Region: Herpes_ICP4_N; cl17480 930170015534 AAA-like domain; Region: AAA_10; pfam12846 930170015535 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 930170015536 TcpE family; Region: TcpE; pfam12648 930170015537 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 930170015538 Trp repressor protein; Region: Trp_repressor; cl17266 930170015539 RES domain; Region: RES; pfam08808 930170015540 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 930170015541 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 930170015542 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 930170015543 Replication-relaxation; Region: Replic_Relax; pfam13814 930170015544 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 930170015545 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930170015546 putative active site [active] 930170015547 putative NTP binding site [chemical binding]; other site 930170015548 putative nucleic acid binding site [nucleotide binding]; other site 930170015549 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 930170015550 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 930170015551 MPN+ (JAMM) motif; other site 930170015552 Zinc-binding site [ion binding]; other site 930170015553 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 930170015554 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930170015555 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930170015556 peptide binding site [polypeptide binding]; other site 930170015557 CAAX protease self-immunity; Region: Abi; pfam02517 930170015558 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 930170015559 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 930170015560 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 930170015561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170015562 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930170015563 Walker A motif; other site 930170015564 ATP binding site [chemical binding]; other site 930170015565 Walker B motif; other site 930170015566 arginine finger; other site 930170015567 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930170015568 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930170015569 catalytic residues [active] 930170015570 catalytic nucleophile [active] 930170015571 Presynaptic Site I dimer interface [polypeptide binding]; other site 930170015572 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930170015573 Synaptic Flat tetramer interface [polypeptide binding]; other site 930170015574 Synaptic Site I dimer interface [polypeptide binding]; other site 930170015575 DNA binding site [nucleotide binding] 930170015576 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930170015577 DNA-binding interface [nucleotide binding]; DNA binding site 930170015578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930170015579 non-specific DNA binding site [nucleotide binding]; other site 930170015580 salt bridge; other site 930170015581 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930170015582 sequence-specific DNA binding site [nucleotide binding]; other site 930170015583 AAA-like domain; Region: AAA_10; pfam12846 930170015584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930170015585 Walker A/P-loop; other site 930170015586 ATP binding site [chemical binding]; other site 930170015587 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 930170015588 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 930170015589 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170015590 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 930170015591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930170015592 Walker A motif; other site 930170015593 ATP binding site [chemical binding]; other site 930170015594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 930170015595 Integrase core domain; Region: rve; pfam00665 930170015596 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930170015597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930170015598 DNA-binding site [nucleotide binding]; DNA binding site 930170015599 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930170015600 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930170015601 DNA binding residues [nucleotide binding] 930170015602 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 930170015603 DNA binding residues [nucleotide binding] 930170015604 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930170015605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170015606 active site 930170015607 DNA binding site [nucleotide binding] 930170015608 Int/Topo IB signature motif; other site 930170015609 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 930170015610 delta endotoxin; Region: Endotoxin_M; pfam00555 930170015611 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 930170015612 putative metal binding site [ion binding]; other site 930170015613 potential frameshift: common BLAST hit: gi|169830964|ref|YP_001716946.1| phage integrase family protein 930170015614 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170015615 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170015616 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170015617 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 930170015618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930170015619 active site 930170015620 DNA binding site [nucleotide binding] 930170015621 Int/Topo IB signature motif; other site 930170015622 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170015623 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 930170015624 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 930170015625 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 930170015626 PhnA protein; Region: PhnA; pfam03831 930170015627 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 930170015628 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 930170015629 putative transporter; Provisional; Region: PRK11660 930170015630 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930170015631 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930170015632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930170015633 dimerization interface [polypeptide binding]; other site 930170015634 putative DNA binding site [nucleotide binding]; other site 930170015635 putative Zn2+ binding site [ion binding]; other site 930170015636 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930170015637 putative active site [active] 930170015638 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930170015639 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930170015640 catalytic residues [active] 930170015641 catalytic nucleophile [active] 930170015642 Presynaptic Site I dimer interface [polypeptide binding]; other site 930170015643 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930170015644 Synaptic Flat tetramer interface [polypeptide binding]; other site 930170015645 Synaptic Site I dimer interface [polypeptide binding]; other site 930170015646 DNA binding site [nucleotide binding] 930170015647 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930170015648 DNA-binding interface [nucleotide binding]; DNA binding site 930170015649 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 930170015650 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526