-- dump date 20140618_235746 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1279365000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1279365000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1279365000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365000004 Walker A motif; other site 1279365000005 ATP binding site [chemical binding]; other site 1279365000006 Walker B motif; other site 1279365000007 arginine finger; other site 1279365000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1279365000009 DnaA box-binding interface [nucleotide binding]; other site 1279365000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1279365000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1279365000012 putative DNA binding surface [nucleotide binding]; other site 1279365000013 dimer interface [polypeptide binding]; other site 1279365000014 beta-clamp/clamp loader binding surface; other site 1279365000015 beta-clamp/translesion DNA polymerase binding surface; other site 1279365000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1279365000017 recombination protein F; Reviewed; Region: recF; PRK00064 1279365000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1279365000019 Walker A/P-loop; other site 1279365000020 ATP binding site [chemical binding]; other site 1279365000021 Q-loop/lid; other site 1279365000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365000023 ABC transporter signature motif; other site 1279365000024 Walker B; other site 1279365000025 D-loop; other site 1279365000026 H-loop/switch region; other site 1279365000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1279365000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365000029 Mg2+ binding site [ion binding]; other site 1279365000030 G-X-G motif; other site 1279365000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1279365000032 anchoring element; other site 1279365000033 dimer interface [polypeptide binding]; other site 1279365000034 ATP binding site [chemical binding]; other site 1279365000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1279365000036 active site 1279365000037 putative metal-binding site [ion binding]; other site 1279365000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1279365000039 DNA gyrase subunit A; Validated; Region: PRK05560 1279365000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1279365000041 CAP-like domain; other site 1279365000042 active site 1279365000043 primary dimer interface [polypeptide binding]; other site 1279365000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365000050 YaaC-like Protein; Region: YaaC; pfam14175 1279365000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1279365000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1279365000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1279365000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1279365000055 active site 1279365000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1279365000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1279365000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1279365000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1279365000061 active site 1279365000062 multimer interface [polypeptide binding]; other site 1279365000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1279365000064 predicted active site [active] 1279365000065 catalytic triad [active] 1279365000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 1279365000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1279365000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1279365000069 dimer interface [polypeptide binding]; other site 1279365000070 active site 1279365000071 motif 1; other site 1279365000072 motif 2; other site 1279365000073 motif 3; other site 1279365000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 1279365000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1279365000076 DNA binding residues [nucleotide binding] 1279365000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1279365000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1279365000079 Substrate-binding site [chemical binding]; other site 1279365000080 Substrate specificity [chemical binding]; other site 1279365000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1279365000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1279365000083 Substrate-binding site [chemical binding]; other site 1279365000084 Substrate specificity [chemical binding]; other site 1279365000085 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365000086 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1279365000087 catalytic triad [active] 1279365000088 conserved cis-peptide bond; other site 1279365000089 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1279365000090 nucleoside/Zn binding site; other site 1279365000091 dimer interface [polypeptide binding]; other site 1279365000092 catalytic motif [active] 1279365000093 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1279365000094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365000095 Walker A motif; other site 1279365000096 ATP binding site [chemical binding]; other site 1279365000097 Walker B motif; other site 1279365000098 arginine finger; other site 1279365000099 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1279365000100 hypothetical protein; Validated; Region: PRK00153 1279365000101 recombination protein RecR; Reviewed; Region: recR; PRK00076 1279365000102 RecR protein; Region: RecR; pfam02132 1279365000103 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1279365000104 putative active site [active] 1279365000105 putative metal-binding site [ion binding]; other site 1279365000106 tetramer interface [polypeptide binding]; other site 1279365000107 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1279365000108 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1279365000109 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1279365000110 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1279365000111 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1279365000112 homodimer interface [polypeptide binding]; other site 1279365000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365000114 catalytic residue [active] 1279365000115 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1279365000116 thymidylate kinase; Validated; Region: tmk; PRK00698 1279365000117 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1279365000118 TMP-binding site; other site 1279365000119 ATP-binding site [chemical binding]; other site 1279365000120 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1279365000121 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1279365000122 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1279365000123 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1279365000124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365000125 S-adenosylmethionine binding site [chemical binding]; other site 1279365000126 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1279365000127 putative active site [active] 1279365000128 GIY-YIG motif/motif A; other site 1279365000129 putative metal binding site [ion binding]; other site 1279365000130 Predicted methyltransferases [General function prediction only]; Region: COG0313 1279365000131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1279365000132 putative SAM binding site [chemical binding]; other site 1279365000133 putative homodimer interface [polypeptide binding]; other site 1279365000134 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1279365000135 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1279365000136 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1279365000137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1279365000138 active site 1279365000139 HIGH motif; other site 1279365000140 KMSKS motif; other site 1279365000141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1279365000142 tRNA binding surface [nucleotide binding]; other site 1279365000143 anticodon binding site; other site 1279365000144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1279365000145 dimer interface [polypeptide binding]; other site 1279365000146 putative tRNA-binding site [nucleotide binding]; other site 1279365000147 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1279365000148 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1279365000149 active site 1279365000150 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1279365000151 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1279365000152 putative active site [active] 1279365000153 putative metal binding site [ion binding]; other site 1279365000154 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1279365000155 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1279365000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365000157 S-adenosylmethionine binding site [chemical binding]; other site 1279365000158 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1279365000159 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1279365000160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1279365000161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1279365000162 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1279365000163 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1279365000164 pur operon repressor; Provisional; Region: PRK09213 1279365000165 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1279365000166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365000167 active site 1279365000168 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1279365000169 homotrimer interaction site [polypeptide binding]; other site 1279365000170 putative active site [active] 1279365000171 regulatory protein SpoVG; Reviewed; Region: PRK13259 1279365000172 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1279365000173 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1279365000174 Substrate binding site; other site 1279365000175 Mg++ binding site; other site 1279365000176 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1279365000177 active site 1279365000178 substrate binding site [chemical binding]; other site 1279365000179 CoA binding site [chemical binding]; other site 1279365000180 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1279365000181 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1279365000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365000183 active site 1279365000184 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1279365000185 putative active site [active] 1279365000186 catalytic residue [active] 1279365000187 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1279365000188 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1279365000189 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1279365000190 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1279365000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365000192 ATP binding site [chemical binding]; other site 1279365000193 putative Mg++ binding site [ion binding]; other site 1279365000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365000195 nucleotide binding region [chemical binding]; other site 1279365000196 ATP-binding site [chemical binding]; other site 1279365000197 TRCF domain; Region: TRCF; pfam03461 1279365000198 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1279365000199 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1279365000200 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1279365000201 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1279365000202 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1279365000203 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1279365000204 putative SAM binding site [chemical binding]; other site 1279365000205 putative homodimer interface [polypeptide binding]; other site 1279365000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1279365000207 homodimer interface [polypeptide binding]; other site 1279365000208 metal binding site [ion binding]; metal-binding site 1279365000209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1279365000210 homodimer interface [polypeptide binding]; other site 1279365000211 active site 1279365000212 putative chemical substrate binding site [chemical binding]; other site 1279365000213 metal binding site [ion binding]; metal-binding site 1279365000214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365000215 RNA binding surface [nucleotide binding]; other site 1279365000216 sporulation protein YabP; Region: spore_yabP; TIGR02892 1279365000217 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1279365000218 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1279365000219 Septum formation initiator; Region: DivIC; pfam04977 1279365000220 hypothetical protein; Provisional; Region: PRK08582 1279365000221 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1279365000222 RNA binding site [nucleotide binding]; other site 1279365000223 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1279365000224 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1279365000225 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1279365000226 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1279365000227 Ligand Binding Site [chemical binding]; other site 1279365000228 TilS substrate binding domain; Region: TilS; pfam09179 1279365000229 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1279365000230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365000231 active site 1279365000232 FtsH Extracellular; Region: FtsH_ext; pfam06480 1279365000233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1279365000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365000235 Walker A motif; other site 1279365000236 ATP binding site [chemical binding]; other site 1279365000237 Walker B motif; other site 1279365000238 arginine finger; other site 1279365000239 Peptidase family M41; Region: Peptidase_M41; pfam01434 1279365000240 pantothenate kinase; Reviewed; Region: PRK13318 1279365000241 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1279365000242 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1279365000243 dimerization interface [polypeptide binding]; other site 1279365000244 domain crossover interface; other site 1279365000245 redox-dependent activation switch; other site 1279365000246 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1279365000247 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1279365000248 dimer interface [polypeptide binding]; other site 1279365000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365000250 catalytic residue [active] 1279365000251 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1279365000252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1279365000253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1279365000254 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1279365000255 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1279365000256 glutamine binding [chemical binding]; other site 1279365000257 catalytic triad [active] 1279365000258 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1279365000259 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 1279365000260 homodimer interface [polypeptide binding]; other site 1279365000261 substrate-cofactor binding pocket; other site 1279365000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365000263 catalytic residue [active] 1279365000264 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1279365000265 dihydropteroate synthase; Region: DHPS; TIGR01496 1279365000266 substrate binding pocket [chemical binding]; other site 1279365000267 dimer interface [polypeptide binding]; other site 1279365000268 inhibitor binding site; inhibition site 1279365000269 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1279365000270 homooctamer interface [polypeptide binding]; other site 1279365000271 active site 1279365000272 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1279365000273 catalytic center binding site [active] 1279365000274 ATP binding site [chemical binding]; other site 1279365000275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365000276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365000277 non-specific DNA binding site [nucleotide binding]; other site 1279365000278 salt bridge; other site 1279365000279 sequence-specific DNA binding site [nucleotide binding]; other site 1279365000280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1279365000281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1279365000282 FMN binding site [chemical binding]; other site 1279365000283 active site 1279365000284 catalytic residues [active] 1279365000285 substrate binding site [chemical binding]; other site 1279365000286 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1279365000287 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1279365000288 dimer interface [polypeptide binding]; other site 1279365000289 putative anticodon binding site; other site 1279365000290 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1279365000291 motif 1; other site 1279365000292 active site 1279365000293 motif 2; other site 1279365000294 motif 3; other site 1279365000295 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1279365000296 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1279365000297 UvrB/uvrC motif; Region: UVR; pfam02151 1279365000298 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1279365000299 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1279365000300 ADP binding site [chemical binding]; other site 1279365000301 phosphagen binding site; other site 1279365000302 substrate specificity loop; other site 1279365000303 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1279365000304 Clp amino terminal domain; Region: Clp_N; pfam02861 1279365000305 Clp amino terminal domain; Region: Clp_N; pfam02861 1279365000306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365000307 Walker A motif; other site 1279365000308 ATP binding site [chemical binding]; other site 1279365000309 Walker B motif; other site 1279365000310 arginine finger; other site 1279365000311 UvrB/uvrC motif; Region: UVR; pfam02151 1279365000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365000313 Walker A motif; other site 1279365000314 ATP binding site [chemical binding]; other site 1279365000315 Walker B motif; other site 1279365000316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1279365000317 DNA repair protein RadA; Provisional; Region: PRK11823 1279365000318 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1279365000319 Walker A motif/ATP binding site; other site 1279365000320 ATP binding site [chemical binding]; other site 1279365000321 Walker B motif; other site 1279365000322 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1279365000323 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1279365000324 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1279365000325 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1279365000326 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1279365000327 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1279365000328 putative active site [active] 1279365000329 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1279365000330 substrate binding site; other site 1279365000331 dimer interface; other site 1279365000332 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1279365000333 homotrimer interaction site [polypeptide binding]; other site 1279365000334 zinc binding site [ion binding]; other site 1279365000335 CDP-binding sites; other site 1279365000336 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1279365000337 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1279365000338 active site 1279365000339 HIGH motif; other site 1279365000340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1279365000341 active site 1279365000342 KMSKS motif; other site 1279365000343 serine O-acetyltransferase; Region: cysE; TIGR01172 1279365000344 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1279365000345 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1279365000346 trimer interface [polypeptide binding]; other site 1279365000347 active site 1279365000348 substrate binding site [chemical binding]; other site 1279365000349 CoA binding site [chemical binding]; other site 1279365000350 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1279365000351 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1279365000352 active site 1279365000353 HIGH motif; other site 1279365000354 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1279365000355 KMSKS motif; other site 1279365000356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1279365000357 tRNA binding surface [nucleotide binding]; other site 1279365000358 anticodon binding site; other site 1279365000359 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1279365000360 active site 1279365000361 metal binding site [ion binding]; metal-binding site 1279365000362 dimerization interface [polypeptide binding]; other site 1279365000363 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1279365000364 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1279365000365 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1279365000366 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1279365000367 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 1279365000368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365000369 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1279365000370 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1279365000371 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1279365000372 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1279365000373 putative homodimer interface [polypeptide binding]; other site 1279365000374 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1279365000375 heterodimer interface [polypeptide binding]; other site 1279365000376 homodimer interface [polypeptide binding]; other site 1279365000377 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1279365000378 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1279365000379 23S rRNA interface [nucleotide binding]; other site 1279365000380 L7/L12 interface [polypeptide binding]; other site 1279365000381 putative thiostrepton binding site; other site 1279365000382 L25 interface [polypeptide binding]; other site 1279365000383 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1279365000384 mRNA/rRNA interface [nucleotide binding]; other site 1279365000385 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1279365000386 23S rRNA interface [nucleotide binding]; other site 1279365000387 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1279365000388 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1279365000389 core dimer interface [polypeptide binding]; other site 1279365000390 peripheral dimer interface [polypeptide binding]; other site 1279365000391 L10 interface [polypeptide binding]; other site 1279365000392 L11 interface [polypeptide binding]; other site 1279365000393 putative EF-Tu interaction site [polypeptide binding]; other site 1279365000394 putative EF-G interaction site [polypeptide binding]; other site 1279365000395 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1279365000396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365000397 S-adenosylmethionine binding site [chemical binding]; other site 1279365000398 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 1279365000399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1279365000400 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1279365000401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1279365000402 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1279365000403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1279365000404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1279365000405 RPB10 interaction site [polypeptide binding]; other site 1279365000406 RPB1 interaction site [polypeptide binding]; other site 1279365000407 RPB11 interaction site [polypeptide binding]; other site 1279365000408 RPB3 interaction site [polypeptide binding]; other site 1279365000409 RPB12 interaction site [polypeptide binding]; other site 1279365000410 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1279365000411 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1279365000412 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1279365000413 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1279365000414 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1279365000415 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1279365000416 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1279365000417 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1279365000418 G-loop; other site 1279365000419 DNA binding site [nucleotide binding] 1279365000420 hypothetical protein; Provisional; Region: PRK06683 1279365000421 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1279365000422 S17 interaction site [polypeptide binding]; other site 1279365000423 S8 interaction site; other site 1279365000424 16S rRNA interaction site [nucleotide binding]; other site 1279365000425 streptomycin interaction site [chemical binding]; other site 1279365000426 23S rRNA interaction site [nucleotide binding]; other site 1279365000427 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1279365000428 30S ribosomal protein S7; Validated; Region: PRK05302 1279365000429 elongation factor G; Reviewed; Region: PRK00007 1279365000430 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1279365000431 G1 box; other site 1279365000432 putative GEF interaction site [polypeptide binding]; other site 1279365000433 GTP/Mg2+ binding site [chemical binding]; other site 1279365000434 Switch I region; other site 1279365000435 G2 box; other site 1279365000436 G3 box; other site 1279365000437 Switch II region; other site 1279365000438 G4 box; other site 1279365000439 G5 box; other site 1279365000440 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1279365000441 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1279365000442 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1279365000443 elongation factor Tu; Reviewed; Region: PRK00049 1279365000444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1279365000445 G1 box; other site 1279365000446 GEF interaction site [polypeptide binding]; other site 1279365000447 GTP/Mg2+ binding site [chemical binding]; other site 1279365000448 Switch I region; other site 1279365000449 G2 box; other site 1279365000450 G3 box; other site 1279365000451 Switch II region; other site 1279365000452 G4 box; other site 1279365000453 G5 box; other site 1279365000454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1279365000455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1279365000456 Antibiotic Binding Site [chemical binding]; other site 1279365000457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1279365000458 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1279365000459 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1279365000460 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1279365000461 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1279365000462 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1279365000463 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1279365000464 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1279365000465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1279365000466 putative translocon binding site; other site 1279365000467 protein-rRNA interface [nucleotide binding]; other site 1279365000468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1279365000469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1279365000470 G-X-X-G motif; other site 1279365000471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1279365000472 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1279365000473 23S rRNA interface [nucleotide binding]; other site 1279365000474 5S rRNA interface [nucleotide binding]; other site 1279365000475 putative antibiotic binding site [chemical binding]; other site 1279365000476 L25 interface [polypeptide binding]; other site 1279365000477 L27 interface [polypeptide binding]; other site 1279365000478 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1279365000479 23S rRNA interface [nucleotide binding]; other site 1279365000480 putative translocon interaction site; other site 1279365000481 signal recognition particle (SRP54) interaction site; other site 1279365000482 L23 interface [polypeptide binding]; other site 1279365000483 trigger factor interaction site; other site 1279365000484 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1279365000485 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1279365000486 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1279365000487 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1279365000488 RNA binding site [nucleotide binding]; other site 1279365000489 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1279365000490 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1279365000491 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1279365000492 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1279365000493 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1279365000494 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1279365000495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1279365000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1279365000497 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1279365000498 5S rRNA interface [nucleotide binding]; other site 1279365000499 L27 interface [polypeptide binding]; other site 1279365000500 23S rRNA interface [nucleotide binding]; other site 1279365000501 L5 interface [polypeptide binding]; other site 1279365000502 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1279365000503 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1279365000504 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1279365000505 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1279365000506 23S rRNA binding site [nucleotide binding]; other site 1279365000507 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1279365000508 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 1279365000509 SecY translocase; Region: SecY; pfam00344 1279365000510 adenylate kinase; Reviewed; Region: adk; PRK00279 1279365000511 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1279365000512 AMP-binding site [chemical binding]; other site 1279365000513 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1279365000514 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1279365000515 active site 1279365000516 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1279365000517 rRNA binding site [nucleotide binding]; other site 1279365000518 predicted 30S ribosome binding site; other site 1279365000519 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1279365000520 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1279365000521 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1279365000522 30S ribosomal protein S11; Validated; Region: PRK05309 1279365000523 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1279365000524 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1279365000525 alphaNTD - beta interaction site [polypeptide binding]; other site 1279365000526 alphaNTD homodimer interface [polypeptide binding]; other site 1279365000527 alphaNTD - beta' interaction site [polypeptide binding]; other site 1279365000528 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1279365000529 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1279365000530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1279365000531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1279365000532 Walker A/P-loop; other site 1279365000533 ATP binding site [chemical binding]; other site 1279365000534 Q-loop/lid; other site 1279365000535 ABC transporter signature motif; other site 1279365000536 Walker B; other site 1279365000537 D-loop; other site 1279365000538 H-loop/switch region; other site 1279365000539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1279365000540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1279365000541 Walker A/P-loop; other site 1279365000542 ATP binding site [chemical binding]; other site 1279365000543 Q-loop/lid; other site 1279365000544 ABC transporter signature motif; other site 1279365000545 Walker B; other site 1279365000546 D-loop; other site 1279365000547 H-loop/switch region; other site 1279365000548 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1279365000549 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1279365000550 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1279365000551 dimerization interface 3.5A [polypeptide binding]; other site 1279365000552 active site 1279365000553 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1279365000554 23S rRNA interface [nucleotide binding]; other site 1279365000555 L3 interface [polypeptide binding]; other site 1279365000556 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1279365000557 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1279365000558 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1279365000559 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1279365000560 active site 1279365000561 metal binding site [ion binding]; metal-binding site 1279365000562 Domain of unknown function DUF59; Region: DUF59; cl00941 1279365000563 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1279365000564 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1279365000565 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1279365000566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365000567 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1279365000568 NodB motif; other site 1279365000569 putative active site [active] 1279365000570 putative catalytic site [active] 1279365000571 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1279365000572 Arginase family; Region: Arginase; cd09989 1279365000573 agmatinase; Region: agmatinase; TIGR01230 1279365000574 active site 1279365000575 Mn binding site [ion binding]; other site 1279365000576 oligomer interface [polypeptide binding]; other site 1279365000577 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1279365000578 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1279365000579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1279365000580 YbbR-like protein; Region: YbbR; pfam07949 1279365000581 YbbR-like protein; Region: YbbR; pfam07949 1279365000582 YbbR-like protein; Region: YbbR; pfam07949 1279365000583 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1279365000584 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1279365000585 active site 1279365000586 substrate binding site [chemical binding]; other site 1279365000587 metal binding site [ion binding]; metal-binding site 1279365000588 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1279365000589 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1279365000590 glutaminase active site [active] 1279365000591 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1279365000592 dimer interface [polypeptide binding]; other site 1279365000593 active site 1279365000594 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1279365000595 dimer interface [polypeptide binding]; other site 1279365000596 active site 1279365000597 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1279365000598 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1279365000599 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1279365000600 Predicted membrane protein [Function unknown]; Region: COG2259 1279365000601 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 1279365000602 classical (c) SDRs; Region: SDR_c; cd05233 1279365000603 NAD(P) binding site [chemical binding]; other site 1279365000604 active site 1279365000605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365000606 ABC-ATPase subunit interface; other site 1279365000607 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1279365000608 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1279365000609 Walker A/P-loop; other site 1279365000610 ATP binding site [chemical binding]; other site 1279365000611 Q-loop/lid; other site 1279365000612 ABC transporter signature motif; other site 1279365000613 Walker B; other site 1279365000614 D-loop; other site 1279365000615 H-loop/switch region; other site 1279365000616 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1279365000617 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1279365000618 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1279365000619 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1279365000620 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365000621 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1279365000622 putative NAD(P) binding site [chemical binding]; other site 1279365000623 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1279365000624 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365000625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365000626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365000627 putative substrate translocation pore; other site 1279365000628 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 1279365000629 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1279365000630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365000631 putative substrate translocation pore; other site 1279365000632 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 1279365000633 YusW-like protein; Region: YusW; pfam14039 1279365000634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365000635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1279365000636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365000637 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1279365000638 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365000639 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365000640 peptide binding site [polypeptide binding]; other site 1279365000641 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365000642 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365000643 peptide binding site [polypeptide binding]; other site 1279365000644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365000645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365000646 active site 1279365000647 catalytic tetrad [active] 1279365000648 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 1279365000649 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1279365000650 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1279365000651 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1279365000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365000653 dimer interface [polypeptide binding]; other site 1279365000654 conserved gate region; other site 1279365000655 putative PBP binding loops; other site 1279365000656 ABC-ATPase subunit interface; other site 1279365000657 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1279365000658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1279365000659 dimerization interface [polypeptide binding]; other site 1279365000660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365000661 membrane-bound complex binding site; other site 1279365000662 hinge residues; other site 1279365000663 DNA binding domain, excisionase family; Region: excise; TIGR01764 1279365000664 PBP superfamily domain; Region: PBP_like; pfam12727 1279365000665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365000666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365000667 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1279365000668 putative dimerization interface [polypeptide binding]; other site 1279365000669 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365000670 EamA-like transporter family; Region: EamA; pfam00892 1279365000671 YrzO-like protein; Region: YrzO; pfam14142 1279365000672 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1279365000673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1279365000674 putative acyl-acceptor binding pocket; other site 1279365000675 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365000676 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365000677 DNA binding site [nucleotide binding] 1279365000678 domain linker motif; other site 1279365000679 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1279365000680 putative ligand binding site [chemical binding]; other site 1279365000681 putative dimerization interface [polypeptide binding]; other site 1279365000682 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365000683 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365000684 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365000685 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365000686 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1279365000687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365000688 Transposase; Region: HTH_Tnp_1; cl17663 1279365000689 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365000690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365000691 HTH-like domain; Region: HTH_21; pfam13276 1279365000692 Integrase core domain; Region: rve; pfam00665 1279365000693 Integrase core domain; Region: rve_2; pfam13333 1279365000694 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1279365000695 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1279365000696 active site 1279365000697 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1279365000698 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1279365000699 NodB motif; other site 1279365000700 putative active site [active] 1279365000701 putative catalytic site [active] 1279365000702 putative Zn binding site [ion binding]; other site 1279365000703 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1279365000704 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1279365000705 catalytic residue [active] 1279365000706 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1279365000707 nucleotide binding site/active site [active] 1279365000708 HIT family signature motif; other site 1279365000709 catalytic residue [active] 1279365000710 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365000711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365000712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365000713 ABC transporter; Region: ABC_tran_2; pfam12848 1279365000714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365000715 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1279365000716 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1279365000717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1279365000718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1279365000719 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365000720 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365000721 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365000722 putative active site [active] 1279365000723 putative NTP binding site [chemical binding]; other site 1279365000724 putative nucleic acid binding site [nucleotide binding]; other site 1279365000725 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365000726 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1279365000727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365000728 ABC-ATPase subunit interface; other site 1279365000729 putative PBP binding loops; other site 1279365000730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1279365000731 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1279365000732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365000733 dimer interface [polypeptide binding]; other site 1279365000734 conserved gate region; other site 1279365000735 putative PBP binding loops; other site 1279365000736 ABC-ATPase subunit interface; other site 1279365000737 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1279365000738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1279365000739 Walker A/P-loop; other site 1279365000740 ATP binding site [chemical binding]; other site 1279365000741 Q-loop/lid; other site 1279365000742 ABC transporter signature motif; other site 1279365000743 Walker B; other site 1279365000744 D-loop; other site 1279365000745 H-loop/switch region; other site 1279365000746 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1279365000747 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1279365000748 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1279365000749 Walker A/P-loop; other site 1279365000750 ATP binding site [chemical binding]; other site 1279365000751 Q-loop/lid; other site 1279365000752 ABC transporter signature motif; other site 1279365000753 Walker B; other site 1279365000754 D-loop; other site 1279365000755 H-loop/switch region; other site 1279365000756 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1279365000757 putative transposase OrfB; Reviewed; Region: PHA02517 1279365000758 HTH-like domain; Region: HTH_21; pfam13276 1279365000759 Integrase core domain; Region: rve; pfam00665 1279365000760 Integrase core domain; Region: rve_2; pfam13333 1279365000761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365000762 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365000763 active site 1279365000764 motif I; other site 1279365000765 motif II; other site 1279365000766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365000767 motif II; other site 1279365000768 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1279365000769 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1279365000770 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1279365000771 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 1279365000772 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1279365000773 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1279365000774 dimer interface [polypeptide binding]; other site 1279365000775 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1279365000776 active site 1279365000777 Fe binding site [ion binding]; other site 1279365000778 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1279365000779 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1279365000780 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1279365000781 amino acid transporter; Region: 2A0306; TIGR00909 1279365000782 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1279365000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365000784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365000785 putative substrate translocation pore; other site 1279365000786 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1279365000787 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1279365000788 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1279365000789 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1279365000790 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1279365000791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1279365000792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1279365000793 helicase 45; Provisional; Region: PTZ00424 1279365000794 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1279365000795 ATP binding site [chemical binding]; other site 1279365000796 Mg++ binding site [ion binding]; other site 1279365000797 motif III; other site 1279365000798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365000799 nucleotide binding region [chemical binding]; other site 1279365000800 ATP-binding site [chemical binding]; other site 1279365000801 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1279365000802 Rhomboid family; Region: Rhomboid; pfam01694 1279365000803 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1279365000804 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1279365000805 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1279365000806 alanine racemase; Reviewed; Region: alr; PRK00053 1279365000807 active site 1279365000808 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1279365000809 dimer interface [polypeptide binding]; other site 1279365000810 substrate binding site [chemical binding]; other site 1279365000811 catalytic residues [active] 1279365000812 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1279365000813 PemK-like protein; Region: PemK; pfam02452 1279365000814 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1279365000815 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1279365000816 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1279365000817 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1279365000818 RNA binding site [nucleotide binding]; other site 1279365000819 hypothetical protein; Provisional; Region: PRK04351 1279365000820 SprT homologues; Region: SprT; cl01182 1279365000821 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1279365000822 Glycoprotease family; Region: Peptidase_M22; pfam00814 1279365000823 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1279365000824 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1279365000825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365000826 Coenzyme A binding pocket [chemical binding]; other site 1279365000827 UGMP family protein; Validated; Region: PRK09604 1279365000828 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1279365000829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1279365000830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365000831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365000832 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365000833 ABC transporter; Region: ABC_tran_2; pfam12848 1279365000834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365000835 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1279365000836 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1279365000837 CoA binding domain; Region: CoA_binding; pfam02629 1279365000838 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1279365000839 CAAX protease self-immunity; Region: Abi; pfam02517 1279365000840 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1279365000841 oligomerisation interface [polypeptide binding]; other site 1279365000842 mobile loop; other site 1279365000843 roof hairpin; other site 1279365000844 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1279365000845 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1279365000846 ring oligomerisation interface [polypeptide binding]; other site 1279365000847 ATP/Mg binding site [chemical binding]; other site 1279365000848 stacking interactions; other site 1279365000849 hinge regions; other site 1279365000850 GMP synthase; Reviewed; Region: guaA; PRK00074 1279365000851 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1279365000852 AMP/PPi binding site [chemical binding]; other site 1279365000853 candidate oxyanion hole; other site 1279365000854 catalytic triad [active] 1279365000855 potential glutamine specificity residues [chemical binding]; other site 1279365000856 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1279365000857 ATP Binding subdomain [chemical binding]; other site 1279365000858 Ligand Binding sites [chemical binding]; other site 1279365000859 Dimerization subdomain; other site 1279365000860 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1279365000861 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1279365000862 Int/Topo IB signature motif; other site 1279365000863 Domain of unknown function (DUF955); Region: DUF955; cl01076 1279365000864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365000865 non-specific DNA binding site [nucleotide binding]; other site 1279365000866 salt bridge; other site 1279365000867 sequence-specific DNA binding site [nucleotide binding]; other site 1279365000868 Protein of unknown function (DUF739); Region: DUF739; pfam05339 1279365000869 ORF6N domain; Region: ORF6N; pfam10543 1279365000870 ORF6C domain; Region: ORF6C; pfam10552 1279365000871 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1279365000872 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1279365000873 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1279365000874 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1279365000875 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1279365000876 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1279365000877 Int/Topo IB signature motif; other site 1279365000878 Phage terminase, small subunit; Region: Terminase_4; cl01525 1279365000879 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365000880 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1279365000881 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1279365000882 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1279365000883 oligomer interface [polypeptide binding]; other site 1279365000884 active site residues [active] 1279365000885 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365000886 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1279365000887 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1279365000888 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1279365000889 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365000890 Phage-related minor tail protein [Function unknown]; Region: COG5280 1279365000891 Phage tail protein; Region: Sipho_tail; pfam05709 1279365000892 Phage tail protein; Region: Sipho_tail; cl17486 1279365000893 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365000894 Haemolysin XhlA; Region: XhlA; pfam10779 1279365000895 Holin family; Region: Phage_holin_4; pfam05105 1279365000896 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365000897 amidase catalytic site [active] 1279365000898 Zn binding residues [ion binding]; other site 1279365000899 substrate binding site [chemical binding]; other site 1279365000900 Bacterial SH3 domain; Region: SH3_3; cl17532 1279365000901 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365000902 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365000903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365000904 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365000905 recombinase A; Provisional; Region: recA; PRK09354 1279365000906 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1279365000907 hexamer interface [polypeptide binding]; other site 1279365000908 Walker A motif; other site 1279365000909 ATP binding site [chemical binding]; other site 1279365000910 Walker B motif; other site 1279365000911 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365000912 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1279365000913 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365000914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365000915 active site 1279365000916 phosphorylation site [posttranslational modification] 1279365000917 intermolecular recognition site; other site 1279365000918 dimerization interface [polypeptide binding]; other site 1279365000919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365000920 DNA binding site [nucleotide binding] 1279365000921 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1279365000922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365000923 dimerization interface [polypeptide binding]; other site 1279365000924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365000925 dimer interface [polypeptide binding]; other site 1279365000926 phosphorylation site [posttranslational modification] 1279365000927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365000928 ATP binding site [chemical binding]; other site 1279365000929 Mg2+ binding site [ion binding]; other site 1279365000930 G-X-G motif; other site 1279365000931 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365000932 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365000933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1279365000934 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1279365000935 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1279365000936 catalytic residues [active] 1279365000937 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1279365000938 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1279365000939 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1279365000940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365000941 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1279365000942 Walker A/P-loop; other site 1279365000943 ATP binding site [chemical binding]; other site 1279365000944 Q-loop/lid; other site 1279365000945 ABC transporter signature motif; other site 1279365000946 Walker B; other site 1279365000947 D-loop; other site 1279365000948 H-loop/switch region; other site 1279365000949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365000950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365000951 dimer interface [polypeptide binding]; other site 1279365000952 phosphorylation site [posttranslational modification] 1279365000953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365000954 ATP binding site [chemical binding]; other site 1279365000955 Mg2+ binding site [ion binding]; other site 1279365000956 G-X-G motif; other site 1279365000957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365000958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365000959 active site 1279365000960 phosphorylation site [posttranslational modification] 1279365000961 intermolecular recognition site; other site 1279365000962 dimerization interface [polypeptide binding]; other site 1279365000963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365000964 DNA binding site [nucleotide binding] 1279365000965 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 1279365000966 putative ligand binding site [chemical binding]; other site 1279365000967 putative catalytic site [active] 1279365000968 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1279365000969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365000970 S-adenosylmethionine binding site [chemical binding]; other site 1279365000971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365000972 S-adenosylmethionine binding site [chemical binding]; other site 1279365000973 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1279365000974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365000975 Integrase core domain; Region: rve; pfam00665 1279365000976 transposase/IS protein; Provisional; Region: PRK09183 1279365000977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365000978 Walker A motif; other site 1279365000979 ATP binding site [chemical binding]; other site 1279365000980 Walker B motif; other site 1279365000981 arginine finger; other site 1279365000982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1279365000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365000984 NAD(P) binding site [chemical binding]; other site 1279365000985 active site 1279365000986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365000987 S-adenosylmethionine binding site [chemical binding]; other site 1279365000988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1279365000989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1279365000990 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365000991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365000992 active site 1279365000993 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1279365000994 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1279365000995 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1279365000996 NAD binding site [chemical binding]; other site 1279365000997 ATP-grasp domain; Region: ATP-grasp; pfam02222 1279365000998 adenylosuccinate lyase; Provisional; Region: PRK07492 1279365000999 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1279365001000 tetramer interface [polypeptide binding]; other site 1279365001001 active site 1279365001002 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1279365001003 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1279365001004 ATP binding site [chemical binding]; other site 1279365001005 active site 1279365001006 substrate binding site [chemical binding]; other site 1279365001007 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1279365001008 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1279365001009 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1279365001010 putative active site [active] 1279365001011 catalytic triad [active] 1279365001012 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1279365001013 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1279365001014 dimerization interface [polypeptide binding]; other site 1279365001015 ATP binding site [chemical binding]; other site 1279365001016 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1279365001017 dimerization interface [polypeptide binding]; other site 1279365001018 ATP binding site [chemical binding]; other site 1279365001019 amidophosphoribosyltransferase; Provisional; Region: PRK06781 1279365001020 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1279365001021 active site 1279365001022 tetramer interface [polypeptide binding]; other site 1279365001023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365001024 active site 1279365001025 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1279365001026 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1279365001027 dimerization interface [polypeptide binding]; other site 1279365001028 putative ATP binding site [chemical binding]; other site 1279365001029 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1279365001030 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1279365001031 active site 1279365001032 substrate binding site [chemical binding]; other site 1279365001033 cosubstrate binding site; other site 1279365001034 catalytic site [active] 1279365001035 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1279365001036 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1279365001037 purine monophosphate binding site [chemical binding]; other site 1279365001038 dimer interface [polypeptide binding]; other site 1279365001039 putative catalytic residues [active] 1279365001040 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1279365001041 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1279365001042 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1279365001043 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1279365001044 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1279365001045 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1279365001046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1279365001047 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1279365001048 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1279365001049 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1279365001050 PcrB family; Region: PcrB; pfam01884 1279365001051 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1279365001052 substrate binding site [chemical binding]; other site 1279365001053 putative active site [active] 1279365001054 dimer interface [polypeptide binding]; other site 1279365001055 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1279365001056 Part of AAA domain; Region: AAA_19; pfam13245 1279365001057 Family description; Region: UvrD_C_2; pfam13538 1279365001058 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1279365001059 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1279365001060 nucleotide binding pocket [chemical binding]; other site 1279365001061 K-X-D-G motif; other site 1279365001062 catalytic site [active] 1279365001063 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1279365001064 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1279365001065 Dimer interface [polypeptide binding]; other site 1279365001066 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1279365001067 putative dimer interface [polypeptide binding]; other site 1279365001068 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1279365001069 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1279365001070 putative dimer interface [polypeptide binding]; other site 1279365001071 hypothetical protein; Provisional; Region: PRK10621 1279365001072 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365001073 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1279365001074 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1279365001075 Glutamate binding site [chemical binding]; other site 1279365001076 homodimer interface [polypeptide binding]; other site 1279365001077 NAD binding site [chemical binding]; other site 1279365001078 catalytic residues [active] 1279365001079 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365001080 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1279365001081 catalytic triad [active] 1279365001082 conserved cis-peptide bond; other site 1279365001083 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1279365001084 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1279365001085 Walker A/P-loop; other site 1279365001086 ATP binding site [chemical binding]; other site 1279365001087 Q-loop/lid; other site 1279365001088 ABC transporter signature motif; other site 1279365001089 Walker B; other site 1279365001090 D-loop; other site 1279365001091 H-loop/switch region; other site 1279365001092 NIL domain; Region: NIL; pfam09383 1279365001093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365001094 dimer interface [polypeptide binding]; other site 1279365001095 conserved gate region; other site 1279365001096 ABC-ATPase subunit interface; other site 1279365001097 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1279365001098 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1279365001099 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 1279365001100 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1279365001101 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1279365001102 P loop; other site 1279365001103 Nucleotide binding site [chemical binding]; other site 1279365001104 DTAP/Switch II; other site 1279365001105 Switch I; other site 1279365001106 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1279365001107 putative dimer interface [polypeptide binding]; other site 1279365001108 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365001109 MarR family; Region: MarR; pfam01047 1279365001110 MarR family; Region: MarR_2; cl17246 1279365001111 yiaA/B two helix domain; Region: YiaAB; pfam05360 1279365001112 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1279365001113 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1279365001114 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1279365001115 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1279365001116 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1279365001117 GatB domain; Region: GatB_Yqey; pfam02637 1279365001118 putative lipid kinase; Reviewed; Region: PRK13337 1279365001119 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1279365001120 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1279365001121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365001122 motif II; other site 1279365001123 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1279365001124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365001125 inhibitor-cofactor binding pocket; inhibition site 1279365001126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365001127 catalytic residue [active] 1279365001128 PAS domain; Region: PAS_9; pfam13426 1279365001129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365001130 putative active site [active] 1279365001131 heme pocket [chemical binding]; other site 1279365001132 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1279365001133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365001134 Walker A motif; other site 1279365001135 ATP binding site [chemical binding]; other site 1279365001136 Walker B motif; other site 1279365001137 arginine finger; other site 1279365001138 succinic semialdehyde dehydrogenase; Region: PLN02278 1279365001139 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1279365001140 tetramerization interface [polypeptide binding]; other site 1279365001141 NAD(P) binding site [chemical binding]; other site 1279365001142 catalytic residues [active] 1279365001143 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1279365001144 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1279365001145 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1279365001146 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1279365001147 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365001148 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1279365001149 putative active site [active] 1279365001150 putative metal binding site [ion binding]; other site 1279365001151 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365001152 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365001153 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365001154 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1279365001155 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1279365001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365001157 S-adenosylmethionine binding site [chemical binding]; other site 1279365001158 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1279365001159 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1279365001160 Int/Topo IB signature motif; other site 1279365001161 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365001162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365001163 non-specific DNA binding site [nucleotide binding]; other site 1279365001164 salt bridge; other site 1279365001165 sequence-specific DNA binding site [nucleotide binding]; other site 1279365001166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365001167 sequence-specific DNA binding site [nucleotide binding]; other site 1279365001168 salt bridge; other site 1279365001169 Helix-turn-helix domain; Region: HTH_17; pfam12728 1279365001170 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365001171 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1279365001172 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1279365001173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1279365001174 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1279365001175 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1279365001176 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1279365001177 dUTPase; Region: dUTPase_2; pfam08761 1279365001178 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1279365001179 active site 1279365001180 homodimer interface [polypeptide binding]; other site 1279365001181 metal binding site [ion binding]; metal-binding site 1279365001182 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1279365001183 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1279365001184 YopX protein; Region: YopX; pfam09643 1279365001185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365001186 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365001187 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365001188 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365001189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365001190 DNA binding site [nucleotide binding] 1279365001191 Int/Topo IB signature motif; other site 1279365001192 active site 1279365001193 Helix-turn-helix domain; Region: HTH_17; pfam12728 1279365001194 Phage terminase, small subunit; Region: Terminase_4; cl01525 1279365001195 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365001196 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1279365001197 Phage portal protein; Region: Phage_portal; pfam04860 1279365001198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365001199 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365001200 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365001201 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1279365001202 oligomer interface [polypeptide binding]; other site 1279365001203 Clp protease; Region: CLP_protease; pfam00574 1279365001204 active site residues [active] 1279365001205 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365001206 Phage capsid family; Region: Phage_capsid; pfam05065 1279365001207 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1279365001208 oligomerization interface [polypeptide binding]; other site 1279365001209 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1279365001210 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1279365001211 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1279365001212 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365001213 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1279365001214 Phage-related minor tail protein [Function unknown]; Region: COG5280 1279365001215 2-isopropylmalate synthase, yeast type; Region: leuA_yeast; TIGR00970 1279365001216 Phage tail protein; Region: Sipho_tail; pfam05709 1279365001217 Phage tail protein; Region: Sipho_tail; cl17486 1279365001218 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365001219 Plasmid replication protein; Region: Rep_2; pfam01719 1279365001220 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1279365001221 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1279365001222 active site 1279365001223 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1279365001224 YolD-like protein; Region: YolD; pfam08863 1279365001225 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1279365001226 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365001227 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1279365001228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365001229 active site 1279365001230 DNA binding site [nucleotide binding] 1279365001231 Int/Topo IB signature motif; other site 1279365001232 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1279365001233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365001234 active site 1279365001235 DNA binding site [nucleotide binding] 1279365001236 Int/Topo IB signature motif; other site 1279365001237 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1279365001238 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1279365001239 FMN binding site [chemical binding]; other site 1279365001240 active site 1279365001241 catalytic residues [active] 1279365001242 substrate binding site [chemical binding]; other site 1279365001243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1279365001244 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1279365001245 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1279365001246 Protein of unknown function DUF45; Region: DUF45; pfam01863 1279365001247 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1279365001248 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1279365001249 active site 1279365001250 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1279365001251 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1279365001252 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1279365001253 amidohydrolase; Region: amidohydrolases; TIGR01891 1279365001254 metal binding site [ion binding]; metal-binding site 1279365001255 putative dimer interface [polypeptide binding]; other site 1279365001256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365001257 S-adenosylmethionine binding site [chemical binding]; other site 1279365001258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365001259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365001260 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1279365001261 catalytic residue [active] 1279365001262 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1279365001263 catalytic residues [active] 1279365001264 peroxiredoxin; Region: AhpC; TIGR03137 1279365001265 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1279365001266 dimer interface [polypeptide binding]; other site 1279365001267 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1279365001268 catalytic triad [active] 1279365001269 peroxidatic and resolving cysteines [active] 1279365001270 5-methylribose kinase; Reviewed; Region: PRK12396 1279365001271 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365001272 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1279365001273 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1279365001274 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 1279365001275 intersubunit interface [polypeptide binding]; other site 1279365001276 active site 1279365001277 Zn2+ binding site [ion binding]; other site 1279365001278 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365001279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365001280 ABC-ATPase subunit interface; other site 1279365001281 dimer interface [polypeptide binding]; other site 1279365001282 putative PBP binding regions; other site 1279365001283 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365001284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365001285 ABC-ATPase subunit interface; other site 1279365001286 dimer interface [polypeptide binding]; other site 1279365001287 putative PBP binding regions; other site 1279365001288 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365001289 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1279365001290 putative ligand binding residues [chemical binding]; other site 1279365001291 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1279365001292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365001293 DNA binding domain, excisionase family; Region: excise; TIGR01764 1279365001294 Sm and related proteins; Region: Sm_like; cl00259 1279365001295 Sm1 motif; other site 1279365001296 RNA binding site [nucleotide binding]; other site 1279365001297 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1279365001298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365001299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365001300 dimer interface [polypeptide binding]; other site 1279365001301 phosphorylation site [posttranslational modification] 1279365001302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365001303 ATP binding site [chemical binding]; other site 1279365001304 Mg2+ binding site [ion binding]; other site 1279365001305 G-X-G motif; other site 1279365001306 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1279365001307 hypothetical protein; Provisional; Region: PRK06851 1279365001308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365001309 Walker A motif; other site 1279365001310 ATP binding site [chemical binding]; other site 1279365001311 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1279365001312 benzoate transport; Region: 2A0115; TIGR00895 1279365001313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365001314 putative substrate translocation pore; other site 1279365001315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365001316 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1279365001317 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1279365001318 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1279365001319 [2Fe-2S] cluster binding site [ion binding]; other site 1279365001320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365001321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365001322 FAD dependent oxidoreductase; Region: DAO; pfam01266 1279365001323 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1279365001324 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1279365001325 putative di-iron ligands [ion binding]; other site 1279365001326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365001327 dimer interface [polypeptide binding]; other site 1279365001328 conserved gate region; other site 1279365001329 putative PBP binding loops; other site 1279365001330 ABC-ATPase subunit interface; other site 1279365001331 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1279365001332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365001333 substrate binding pocket [chemical binding]; other site 1279365001334 membrane-bound complex binding site; other site 1279365001335 hinge residues; other site 1279365001336 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1279365001337 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1279365001338 Walker A/P-loop; other site 1279365001339 ATP binding site [chemical binding]; other site 1279365001340 Q-loop/lid; other site 1279365001341 ABC transporter signature motif; other site 1279365001342 Walker B; other site 1279365001343 D-loop; other site 1279365001344 H-loop/switch region; other site 1279365001345 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1279365001346 HAMP domain; Region: HAMP; pfam00672 1279365001347 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365001348 dimer interface [polypeptide binding]; other site 1279365001349 putative CheW interface [polypeptide binding]; other site 1279365001350 Arginine repressor [Transcription]; Region: ArgR; COG1438 1279365001351 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1279365001352 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1279365001353 arginine deiminase; Provisional; Region: PRK01388 1279365001354 ornithine carbamoyltransferase; Validated; Region: PRK02102 1279365001355 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1279365001356 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1279365001357 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1279365001358 carbamate kinase; Reviewed; Region: PRK12686 1279365001359 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1279365001360 putative substrate binding site [chemical binding]; other site 1279365001361 nucleotide binding site [chemical binding]; other site 1279365001362 nucleotide binding site [chemical binding]; other site 1279365001363 homodimer interface [polypeptide binding]; other site 1279365001364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1279365001365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365001366 ligand binding site [chemical binding]; other site 1279365001367 flexible hinge region; other site 1279365001368 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1279365001369 putative switch regulator; other site 1279365001370 non-specific DNA interactions [nucleotide binding]; other site 1279365001371 DNA binding site [nucleotide binding] 1279365001372 sequence specific DNA binding site [nucleotide binding]; other site 1279365001373 putative cAMP binding site [chemical binding]; other site 1279365001374 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1279365001375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365001376 Integrase core domain; Region: rve; pfam00665 1279365001377 transposase/IS protein; Provisional; Region: PRK09183 1279365001378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365001379 Walker A motif; other site 1279365001380 ATP binding site [chemical binding]; other site 1279365001381 Walker B motif; other site 1279365001382 arginine finger; other site 1279365001383 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1279365001384 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1279365001385 Ca binding site [ion binding]; other site 1279365001386 active site 1279365001387 catalytic site [active] 1279365001388 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1279365001389 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1279365001390 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1279365001391 active site turn [active] 1279365001392 phosphorylation site [posttranslational modification] 1279365001393 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1279365001394 putative catalytic site [active] 1279365001395 putative metal binding site [ion binding]; other site 1279365001396 putative phosphate binding site [ion binding]; other site 1279365001397 Predicted membrane protein [Function unknown]; Region: COG1511 1279365001398 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1279365001399 Predicted membrane protein [Function unknown]; Region: COG1511 1279365001400 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1279365001401 dinuclear metal binding motif [ion binding]; other site 1279365001402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365001403 DNA topoisomerase III; Provisional; Region: PRK07726 1279365001404 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1279365001405 active site 1279365001406 putative interdomain interaction site [polypeptide binding]; other site 1279365001407 putative metal-binding site [ion binding]; other site 1279365001408 putative nucleotide binding site [chemical binding]; other site 1279365001409 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1279365001410 domain I; other site 1279365001411 DNA binding groove [nucleotide binding] 1279365001412 phosphate binding site [ion binding]; other site 1279365001413 domain II; other site 1279365001414 domain III; other site 1279365001415 nucleotide binding site [chemical binding]; other site 1279365001416 catalytic site [active] 1279365001417 domain IV; other site 1279365001418 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1279365001419 substrate binding site [chemical binding]; other site 1279365001420 multimerization interface [polypeptide binding]; other site 1279365001421 ATP binding site [chemical binding]; other site 1279365001422 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1279365001423 thiamine phosphate binding site [chemical binding]; other site 1279365001424 active site 1279365001425 pyrophosphate binding site [ion binding]; other site 1279365001426 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1279365001427 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1279365001428 HAMP domain; Region: HAMP; pfam00672 1279365001429 dimerization interface [polypeptide binding]; other site 1279365001430 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365001431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365001432 dimer interface [polypeptide binding]; other site 1279365001433 putative CheW interface [polypeptide binding]; other site 1279365001434 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365001435 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1279365001436 acyl-activating enzyme (AAE) consensus motif; other site 1279365001437 AMP binding site [chemical binding]; other site 1279365001438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365001439 thioester reductase domain; Region: Thioester-redct; TIGR01746 1279365001440 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1279365001441 putative NAD(P) binding site [chemical binding]; other site 1279365001442 active site 1279365001443 putative substrate binding site [chemical binding]; other site 1279365001444 Domain of unknown function DUF77; Region: DUF77; pfam01910 1279365001445 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1279365001446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365001447 dimer interface [polypeptide binding]; other site 1279365001448 conserved gate region; other site 1279365001449 putative PBP binding loops; other site 1279365001450 ABC-ATPase subunit interface; other site 1279365001451 NMT1/THI5 like; Region: NMT1; pfam09084 1279365001452 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1279365001453 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1279365001454 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1279365001455 Walker A/P-loop; other site 1279365001456 ATP binding site [chemical binding]; other site 1279365001457 Q-loop/lid; other site 1279365001458 ABC transporter signature motif; other site 1279365001459 Walker B; other site 1279365001460 D-loop; other site 1279365001461 H-loop/switch region; other site 1279365001462 Glyco_18 domain; Region: Glyco_18; smart00636 1279365001463 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1279365001464 active site 1279365001465 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365001466 Interdomain contacts; other site 1279365001467 Cytokine receptor motif; other site 1279365001468 Cellulose binding domain; Region: CBM_2; pfam00553 1279365001469 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1279365001470 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365001471 catalytic residues [active] 1279365001472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365001473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365001474 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1279365001475 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365001476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365001477 putative substrate translocation pore; other site 1279365001478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365001479 non-specific DNA binding site [nucleotide binding]; other site 1279365001480 salt bridge; other site 1279365001481 sequence-specific DNA binding site [nucleotide binding]; other site 1279365001482 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1279365001483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365001484 putative substrate translocation pore; other site 1279365001485 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1279365001486 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1279365001487 YesK-like protein; Region: YesK; pfam14150 1279365001488 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1279365001489 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1279365001490 dimer interface [polypeptide binding]; other site 1279365001491 motif 1; other site 1279365001492 active site 1279365001493 motif 2; other site 1279365001494 motif 3; other site 1279365001495 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1279365001496 anticodon binding site; other site 1279365001497 zinc-binding site [ion binding]; other site 1279365001498 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1279365001499 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1279365001500 nucleotide binding site [chemical binding]; other site 1279365001501 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1279365001502 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1279365001503 putative metal binding site [ion binding]; other site 1279365001504 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1279365001505 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1279365001506 putative metal binding site [ion binding]; other site 1279365001507 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1279365001508 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1279365001509 putative metal binding site [ion binding]; other site 1279365001510 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1279365001511 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1279365001512 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1279365001513 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1279365001514 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1279365001515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365001516 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1279365001517 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1279365001518 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1279365001519 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1279365001520 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1279365001521 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1279365001522 active site 1279365001523 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 1279365001524 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1279365001525 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1279365001526 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365001527 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1279365001528 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365001529 EamA-like transporter family; Region: EamA; pfam00892 1279365001530 EamA-like transporter family; Region: EamA; pfam00892 1279365001531 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365001532 YhhN-like protein; Region: YhhN; pfam07947 1279365001533 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1279365001534 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365001535 Catalytic site [active] 1279365001536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365001537 binding surface 1279365001538 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365001539 TPR motif; other site 1279365001540 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365001541 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365001542 Predicted membrane protein [Function unknown]; Region: COG2510 1279365001543 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1279365001544 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1279365001545 calcium/proton exchanger (cax); Region: cax; TIGR00378 1279365001546 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1279365001547 YfkD-like protein; Region: YfkD; pfam14167 1279365001548 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1279365001549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365001550 FeS/SAM binding site; other site 1279365001551 YfkB-like domain; Region: YfkB; pfam08756 1279365001552 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1279365001553 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1279365001554 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1279365001555 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1279365001556 NodB motif; other site 1279365001557 active site 1279365001558 catalytic site [active] 1279365001559 Cd binding site [ion binding]; other site 1279365001560 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1279365001561 endonuclease III; Region: ENDO3c; smart00478 1279365001562 minor groove reading motif; other site 1279365001563 helix-hairpin-helix signature motif; other site 1279365001564 substrate binding pocket [chemical binding]; other site 1279365001565 active site 1279365001566 TRAM domain; Region: TRAM; pfam01938 1279365001567 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1279365001568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365001569 S-adenosylmethionine binding site [chemical binding]; other site 1279365001570 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 1279365001571 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1279365001572 dimerization interface 3.5A [polypeptide binding]; other site 1279365001573 active site 1279365001574 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1279365001575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365001576 Walker A motif; other site 1279365001577 ATP binding site [chemical binding]; other site 1279365001578 Walker B motif; other site 1279365001579 arginine finger; other site 1279365001580 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1279365001581 hypothetical protein; Validated; Region: PRK06748; cl17661 1279365001582 S-methylmethionine transporter; Provisional; Region: PRK11387 1279365001583 acetylornithine deacetylase; Validated; Region: PRK08596 1279365001584 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1279365001585 metal binding site [ion binding]; metal-binding site 1279365001586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365001587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365001588 non-specific DNA binding site [nucleotide binding]; other site 1279365001589 salt bridge; other site 1279365001590 sequence-specific DNA binding site [nucleotide binding]; other site 1279365001591 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1279365001592 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1279365001593 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1279365001594 glutaminase A; Region: Gln_ase; TIGR03814 1279365001595 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1279365001596 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1279365001597 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1279365001598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1279365001599 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1279365001600 active site turn [active] 1279365001601 phosphorylation site [posttranslational modification] 1279365001602 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365001603 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365001604 Sm and related proteins; Region: Sm_like; cl00259 1279365001605 heptamer interface [polypeptide binding]; other site 1279365001606 Sm1 motif; other site 1279365001607 hexamer interface [polypeptide binding]; other site 1279365001608 RNA binding site [nucleotide binding]; other site 1279365001609 Sm2 motif; other site 1279365001610 Sm and related proteins; Region: Sm_like; cl00259 1279365001611 heptamer interface [polypeptide binding]; other site 1279365001612 Sm1 motif; other site 1279365001613 hexamer interface [polypeptide binding]; other site 1279365001614 RNA binding site [nucleotide binding]; other site 1279365001615 Sm2 motif; other site 1279365001616 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1279365001617 active site 1279365001618 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365001619 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1279365001620 active site 1279365001621 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1279365001622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365001623 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1279365001624 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1279365001625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1279365001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365001627 NAD(P) binding site [chemical binding]; other site 1279365001628 active site 1279365001629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365001630 active site 1279365001631 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365001632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365001633 active site 1279365001634 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1279365001635 Pyruvate formate lyase 1; Region: PFL1; cd01678 1279365001636 coenzyme A binding site [chemical binding]; other site 1279365001637 active site 1279365001638 catalytic residues [active] 1279365001639 glycine loop; other site 1279365001640 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1279365001641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365001642 FeS/SAM binding site; other site 1279365001643 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1279365001644 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1279365001645 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1279365001646 YfhE-like protein; Region: YfhE; pfam14152 1279365001647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365001648 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1279365001649 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1279365001650 active site 1279365001651 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1279365001652 TIGR01777 family protein; Region: yfcH 1279365001653 putative NAD(P) binding site [chemical binding]; other site 1279365001654 putative active site [active] 1279365001655 recombination regulator RecX; Provisional; Region: recX; PRK14135 1279365001656 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1279365001657 YpzG-like protein; Region: YpzG; pfam14139 1279365001658 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1279365001659 WVELL protein; Region: WVELL; pfam14043 1279365001660 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1279365001661 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1279365001662 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1279365001663 minor groove reading motif; other site 1279365001664 helix-hairpin-helix signature motif; other site 1279365001665 substrate binding pocket [chemical binding]; other site 1279365001666 active site 1279365001667 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1279365001668 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1279365001669 DNA binding and oxoG recognition site [nucleotide binding] 1279365001670 YgaB-like protein; Region: YgaB; pfam14182 1279365001671 hypothetical protein; Provisional; Region: PRK13662 1279365001672 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365001673 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365001674 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1279365001675 Walker A/P-loop; other site 1279365001676 ATP binding site [chemical binding]; other site 1279365001677 Q-loop/lid; other site 1279365001678 ABC transporter signature motif; other site 1279365001679 Walker B; other site 1279365001680 D-loop; other site 1279365001681 H-loop/switch region; other site 1279365001682 Predicted membrane protein [Function unknown]; Region: COG4129 1279365001683 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1279365001684 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1279365001685 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1279365001686 active site 1279365001687 dimer interface [polypeptide binding]; other site 1279365001688 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1279365001689 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1279365001690 active site 1279365001691 FMN binding site [chemical binding]; other site 1279365001692 substrate binding site [chemical binding]; other site 1279365001693 3Fe-4S cluster binding site [ion binding]; other site 1279365001694 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1279365001695 domain_subunit interface; other site 1279365001696 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1279365001697 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365001698 inhibitor-cofactor binding pocket; inhibition site 1279365001699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365001700 catalytic residue [active] 1279365001701 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1279365001702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365001703 Walker A/P-loop; other site 1279365001704 ATP binding site [chemical binding]; other site 1279365001705 Q-loop/lid; other site 1279365001706 ABC transporter signature motif; other site 1279365001707 Walker B; other site 1279365001708 D-loop; other site 1279365001709 H-loop/switch region; other site 1279365001710 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1279365001711 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1279365001712 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1279365001713 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1279365001714 Ion channel; Region: Ion_trans_2; pfam07885 1279365001715 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1279365001716 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1279365001717 catalytic triad [active] 1279365001718 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1279365001719 metal binding site 2 [ion binding]; metal-binding site 1279365001720 putative DNA binding helix; other site 1279365001721 metal binding site 1 [ion binding]; metal-binding site 1279365001722 dimer interface [polypeptide binding]; other site 1279365001723 structural Zn2+ binding site [ion binding]; other site 1279365001724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365001725 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365001726 Coenzyme A binding pocket [chemical binding]; other site 1279365001727 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1279365001728 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 1279365001729 hypothetical protein; Provisional; Region: PRK12378 1279365001730 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1279365001731 nudix motif; other site 1279365001732 Transglycosylase; Region: Transgly; pfam00912 1279365001733 Thioredoxin; Region: Thioredoxin_4; pfam13462 1279365001734 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1279365001735 epoxyqueuosine reductase; Region: TIGR00276 1279365001736 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1279365001737 4Fe-4S binding domain; Region: Fer4; cl02805 1279365001738 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1279365001739 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1279365001740 HEAT-like repeat; Region: HEAT_EZ; pfam13513 1279365001741 Putative amidase domain; Region: Amidase_6; pfam12671 1279365001742 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1279365001743 PAS fold; Region: PAS_4; pfam08448 1279365001744 PAS domain; Region: PAS_9; pfam13426 1279365001745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365001746 putative active site [active] 1279365001747 heme pocket [chemical binding]; other site 1279365001748 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365001749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365001750 metal binding site [ion binding]; metal-binding site 1279365001751 active site 1279365001752 I-site; other site 1279365001753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365001754 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1279365001755 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1279365001756 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1279365001757 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365001758 heme-binding site [chemical binding]; other site 1279365001759 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365001760 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365001761 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365001762 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365001763 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365001764 BCCT family transporter; Region: BCCT; pfam02028 1279365001765 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1279365001766 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365001767 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1279365001768 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1279365001769 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1279365001770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1279365001771 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1279365001772 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1279365001773 Cache domain; Region: Cache_1; pfam02743 1279365001774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365001775 dimerization interface [polypeptide binding]; other site 1279365001776 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365001777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365001778 dimer interface [polypeptide binding]; other site 1279365001779 putative CheW interface [polypeptide binding]; other site 1279365001780 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1279365001781 PAS domain; Region: PAS; smart00091 1279365001782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365001783 ATP binding site [chemical binding]; other site 1279365001784 Mg2+ binding site [ion binding]; other site 1279365001785 G-X-G motif; other site 1279365001786 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1279365001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365001788 active site 1279365001789 phosphorylation site [posttranslational modification] 1279365001790 intermolecular recognition site; other site 1279365001791 dimerization interface [polypeptide binding]; other site 1279365001792 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1279365001793 Citrate transporter; Region: CitMHS; pfam03600 1279365001794 hypothetical protein; Provisional; Region: PRK12784 1279365001795 NosL; Region: NosL; cl01769 1279365001796 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1279365001797 Ankyrin repeat; Region: Ank; pfam00023 1279365001798 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1279365001799 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1279365001800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365001801 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1279365001802 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1279365001803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365001804 Walker A/P-loop; other site 1279365001805 ATP binding site [chemical binding]; other site 1279365001806 Q-loop/lid; other site 1279365001807 ABC transporter signature motif; other site 1279365001808 Walker B; other site 1279365001809 D-loop; other site 1279365001810 H-loop/switch region; other site 1279365001811 TOBE domain; Region: TOBE_2; pfam08402 1279365001812 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1279365001813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365001814 dimer interface [polypeptide binding]; other site 1279365001815 conserved gate region; other site 1279365001816 putative PBP binding loops; other site 1279365001817 ABC-ATPase subunit interface; other site 1279365001818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1279365001819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1279365001820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365001821 dimer interface [polypeptide binding]; other site 1279365001822 conserved gate region; other site 1279365001823 putative PBP binding loops; other site 1279365001824 ABC-ATPase subunit interface; other site 1279365001825 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1279365001826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1279365001827 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365001828 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1279365001829 active site 1279365001830 metal binding site [ion binding]; metal-binding site 1279365001831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365001832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365001833 active site 1279365001834 phosphorylation site [posttranslational modification] 1279365001835 intermolecular recognition site; other site 1279365001836 dimerization interface [polypeptide binding]; other site 1279365001837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365001838 DNA binding site [nucleotide binding] 1279365001839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365001840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365001841 dimer interface [polypeptide binding]; other site 1279365001842 phosphorylation site [posttranslational modification] 1279365001843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365001844 ATP binding site [chemical binding]; other site 1279365001845 Mg2+ binding site [ion binding]; other site 1279365001846 G-X-G motif; other site 1279365001847 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1279365001848 putative active site [active] 1279365001849 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1279365001850 Cache domain; Region: Cache_1; pfam02743 1279365001851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365001852 dimerization interface [polypeptide binding]; other site 1279365001853 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365001854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365001855 dimer interface [polypeptide binding]; other site 1279365001856 putative CheW interface [polypeptide binding]; other site 1279365001857 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1279365001858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365001859 ATP binding site [chemical binding]; other site 1279365001860 Mg2+ binding site [ion binding]; other site 1279365001861 G-X-G motif; other site 1279365001862 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1279365001863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365001864 active site 1279365001865 phosphorylation site [posttranslational modification] 1279365001866 intermolecular recognition site; other site 1279365001867 dimerization interface [polypeptide binding]; other site 1279365001868 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1279365001869 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1279365001870 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1279365001871 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1279365001872 putative NAD(P) binding site [chemical binding]; other site 1279365001873 EamA-like transporter family; Region: EamA; pfam00892 1279365001874 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365001875 EamA-like transporter family; Region: EamA; pfam00892 1279365001876 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365001877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365001878 DNA-binding site [nucleotide binding]; DNA binding site 1279365001879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365001880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365001881 homodimer interface [polypeptide binding]; other site 1279365001882 catalytic residue [active] 1279365001883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1279365001884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365001885 Coenzyme A binding pocket [chemical binding]; other site 1279365001886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365001887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365001888 dimerization interface [polypeptide binding]; other site 1279365001889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365001890 dimer interface [polypeptide binding]; other site 1279365001891 phosphorylation site [posttranslational modification] 1279365001892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365001893 ATP binding site [chemical binding]; other site 1279365001894 Mg2+ binding site [ion binding]; other site 1279365001895 G-X-G motif; other site 1279365001896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365001897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365001898 active site 1279365001899 phosphorylation site [posttranslational modification] 1279365001900 intermolecular recognition site; other site 1279365001901 dimerization interface [polypeptide binding]; other site 1279365001902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365001903 DNA binding site [nucleotide binding] 1279365001904 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1279365001905 Arrestin_N terminal like; Region: LDB19; pfam13002 1279365001906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365001907 Coenzyme A binding pocket [chemical binding]; other site 1279365001908 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1279365001909 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1279365001910 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1279365001911 catalytic loop [active] 1279365001912 iron binding site [ion binding]; other site 1279365001913 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1279365001914 4Fe-4S binding domain; Region: Fer4; pfam00037 1279365001915 4Fe-4S binding domain; Region: Fer4; pfam00037 1279365001916 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1279365001917 [4Fe-4S] binding site [ion binding]; other site 1279365001918 molybdopterin cofactor binding site; other site 1279365001919 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1279365001920 molybdopterin cofactor binding site; other site 1279365001921 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1279365001922 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1279365001923 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1279365001924 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1279365001925 putative active site [active] 1279365001926 catalytic site [active] 1279365001927 putative metal binding site [ion binding]; other site 1279365001928 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1279365001929 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1279365001930 hexamer interface [polypeptide binding]; other site 1279365001931 ligand binding site [chemical binding]; other site 1279365001932 putative active site [active] 1279365001933 NAD(P) binding site [chemical binding]; other site 1279365001934 amino acid transporter; Region: 2A0306; TIGR00909 1279365001935 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1279365001936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1279365001937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365001938 dimerization interface [polypeptide binding]; other site 1279365001939 putative DNA binding site [nucleotide binding]; other site 1279365001940 putative Zn2+ binding site [ion binding]; other site 1279365001941 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1279365001942 metal-binding site [ion binding] 1279365001943 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1279365001944 Heavy-metal-associated domain; Region: HMA; pfam00403 1279365001945 metal-binding site [ion binding] 1279365001946 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365001947 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1279365001948 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1279365001949 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1279365001950 active site 1279365001951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365001952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365001953 non-specific DNA binding site [nucleotide binding]; other site 1279365001954 salt bridge; other site 1279365001955 sequence-specific DNA binding site [nucleotide binding]; other site 1279365001956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365001957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365001958 TPR motif; other site 1279365001959 binding surface 1279365001960 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365001961 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365001962 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365001963 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1279365001964 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1279365001965 active site 1279365001966 Zn binding site [ion binding]; other site 1279365001967 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1279365001968 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365001969 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1279365001970 VanW like protein; Region: VanW; pfam04294 1279365001971 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1279365001972 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365001973 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365001974 Nucleoside recognition; Region: Gate; pfam07670 1279365001975 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365001976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365001977 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365001978 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365001979 putative active site [active] 1279365001980 putative NTP binding site [chemical binding]; other site 1279365001981 putative nucleic acid binding site [nucleotide binding]; other site 1279365001982 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365001983 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365001984 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1279365001985 putative metal binding site [ion binding]; other site 1279365001986 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1279365001987 Domain of unknown function DUF21; Region: DUF21; pfam01595 1279365001988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1279365001989 Transporter associated domain; Region: CorC_HlyC; smart01091 1279365001990 aspartate ammonia-lyase; Region: aspA; TIGR00839 1279365001991 Aspartase; Region: Aspartase; cd01357 1279365001992 active sites [active] 1279365001993 tetramer interface [polypeptide binding]; other site 1279365001994 L-lactate permease; Region: Lactate_perm; cl00701 1279365001995 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1279365001996 transposase/IS protein; Provisional; Region: PRK09183 1279365001997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365001998 Walker A motif; other site 1279365001999 ATP binding site [chemical binding]; other site 1279365002000 Walker B motif; other site 1279365002001 arginine finger; other site 1279365002002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365002003 Integrase core domain; Region: rve; pfam00665 1279365002004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365002005 dimerization interface [polypeptide binding]; other site 1279365002006 putative Zn2+ binding site [ion binding]; other site 1279365002007 putative DNA binding site [nucleotide binding]; other site 1279365002008 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 1279365002009 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1279365002010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002011 putative substrate translocation pore; other site 1279365002012 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365002013 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1279365002014 siderophore binding site; other site 1279365002015 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365002016 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365002017 ABC-ATPase subunit interface; other site 1279365002018 dimer interface [polypeptide binding]; other site 1279365002019 putative PBP binding regions; other site 1279365002020 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1279365002021 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365002022 ABC-ATPase subunit interface; other site 1279365002023 dimer interface [polypeptide binding]; other site 1279365002024 putative PBP binding regions; other site 1279365002025 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1279365002026 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1279365002027 Walker A/P-loop; other site 1279365002028 ATP binding site [chemical binding]; other site 1279365002029 Q-loop/lid; other site 1279365002030 ABC transporter signature motif; other site 1279365002031 Walker B; other site 1279365002032 D-loop; other site 1279365002033 H-loop/switch region; other site 1279365002034 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1279365002035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365002036 S-adenosylmethionine binding site [chemical binding]; other site 1279365002037 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1279365002038 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1279365002039 substrate-cofactor binding pocket; other site 1279365002040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365002041 catalytic residue [active] 1279365002042 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1279365002043 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 1279365002044 NAD binding site [chemical binding]; other site 1279365002045 homodimer interface [polypeptide binding]; other site 1279365002046 active site 1279365002047 putative substrate binding site [chemical binding]; other site 1279365002048 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1279365002049 nudix motif; other site 1279365002050 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1279365002051 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1279365002052 metal ion-dependent adhesion site (MIDAS); other site 1279365002053 MoxR-like ATPases [General function prediction only]; Region: COG0714 1279365002054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365002055 Walker A motif; other site 1279365002056 ATP binding site [chemical binding]; other site 1279365002057 Walker B motif; other site 1279365002058 arginine finger; other site 1279365002059 cardiolipin synthetase; Reviewed; Region: PRK12452 1279365002060 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1279365002061 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1279365002062 putative active site [active] 1279365002063 catalytic site [active] 1279365002064 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1279365002065 putative active site [active] 1279365002066 catalytic site [active] 1279365002067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365002068 PAS domain; Region: PAS_9; pfam13426 1279365002069 putative active site [active] 1279365002070 heme pocket [chemical binding]; other site 1279365002071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365002072 metal binding site [ion binding]; metal-binding site 1279365002073 active site 1279365002074 I-site; other site 1279365002075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365002076 putrescine transporter; Provisional; Region: potE; PRK10655 1279365002077 Spore germination protein; Region: Spore_permease; cl17796 1279365002078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365002079 DNA-binding site [nucleotide binding]; DNA binding site 1279365002080 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1279365002081 UTRA domain; Region: UTRA; pfam07702 1279365002082 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1279365002083 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1279365002084 active site turn [active] 1279365002085 phosphorylation site [posttranslational modification] 1279365002086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1279365002087 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1279365002088 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1279365002089 Ca binding site [ion binding]; other site 1279365002090 active site 1279365002091 catalytic site [active] 1279365002092 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1279365002093 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365002094 Spore germination protein; Region: Spore_permease; cl17796 1279365002095 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365002096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365002097 active site 1279365002098 ATP binding site [chemical binding]; other site 1279365002099 substrate binding site [chemical binding]; other site 1279365002100 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365002101 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1279365002102 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1279365002103 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1279365002104 Walker A/P-loop; other site 1279365002105 ATP binding site [chemical binding]; other site 1279365002106 Q-loop/lid; other site 1279365002107 ABC transporter signature motif; other site 1279365002108 Walker B; other site 1279365002109 D-loop; other site 1279365002110 H-loop/switch region; other site 1279365002111 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1279365002112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365002113 substrate binding pocket [chemical binding]; other site 1279365002114 membrane-bound complex binding site; other site 1279365002115 hinge residues; other site 1279365002116 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1279365002117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002118 dimer interface [polypeptide binding]; other site 1279365002119 conserved gate region; other site 1279365002120 putative PBP binding loops; other site 1279365002121 ABC-ATPase subunit interface; other site 1279365002122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002123 dimer interface [polypeptide binding]; other site 1279365002124 conserved gate region; other site 1279365002125 putative PBP binding loops; other site 1279365002126 ABC-ATPase subunit interface; other site 1279365002127 S-methylmethionine transporter; Provisional; Region: PRK11387 1279365002128 OsmC-like protein; Region: OsmC; pfam02566 1279365002129 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1279365002130 nucleotide binding site/active site [active] 1279365002131 HIT family signature motif; other site 1279365002132 catalytic residue [active] 1279365002133 RNA polymerase sigma factor; Provisional; Region: PRK12542 1279365002134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365002135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365002136 DNA binding residues [nucleotide binding] 1279365002137 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1279365002138 Predicted transcriptional regulator [Transcription]; Region: COG2378 1279365002139 HTH domain; Region: HTH_11; pfam08279 1279365002140 WYL domain; Region: WYL; pfam13280 1279365002141 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1279365002142 RibD C-terminal domain; Region: RibD_C; cl17279 1279365002143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365002144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365002145 dimerization interface [polypeptide binding]; other site 1279365002146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365002147 dimer interface [polypeptide binding]; other site 1279365002148 phosphorylation site [posttranslational modification] 1279365002149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365002150 ATP binding site [chemical binding]; other site 1279365002151 Mg2+ binding site [ion binding]; other site 1279365002152 G-X-G motif; other site 1279365002153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365002154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365002155 active site 1279365002156 phosphorylation site [posttranslational modification] 1279365002157 intermolecular recognition site; other site 1279365002158 dimerization interface [polypeptide binding]; other site 1279365002159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365002160 DNA binding site [nucleotide binding] 1279365002161 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1279365002162 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1279365002163 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1279365002164 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1279365002165 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1279365002166 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1279365002167 Ligand Binding Site [chemical binding]; other site 1279365002168 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 1279365002169 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1279365002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002171 putative substrate translocation pore; other site 1279365002172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365002173 MarR family; Region: MarR; pfam01047 1279365002174 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1279365002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002176 putative substrate translocation pore; other site 1279365002177 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365002178 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365002179 DNA binding site [nucleotide binding] 1279365002180 domain linker motif; other site 1279365002181 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1279365002182 dimerization interface [polypeptide binding]; other site 1279365002183 ligand binding site [chemical binding]; other site 1279365002184 sodium binding site [ion binding]; other site 1279365002185 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1279365002186 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1279365002187 substrate binding site [chemical binding]; other site 1279365002188 dimer interface [polypeptide binding]; other site 1279365002189 ATP binding site [chemical binding]; other site 1279365002190 D-ribose pyranase; Provisional; Region: PRK11797 1279365002191 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1279365002192 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1279365002193 Walker A/P-loop; other site 1279365002194 ATP binding site [chemical binding]; other site 1279365002195 Q-loop/lid; other site 1279365002196 ABC transporter signature motif; other site 1279365002197 Walker B; other site 1279365002198 D-loop; other site 1279365002199 H-loop/switch region; other site 1279365002200 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1279365002201 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1279365002202 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1279365002203 TM-ABC transporter signature motif; other site 1279365002204 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1279365002205 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1279365002206 ligand binding site [chemical binding]; other site 1279365002207 dimerization interface [polypeptide binding]; other site 1279365002208 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1279365002209 active site 1279365002210 intersubunit interactions; other site 1279365002211 catalytic residue [active] 1279365002212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1279365002213 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1279365002214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365002216 putative substrate translocation pore; other site 1279365002217 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1279365002218 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1279365002219 putative NAD(P) binding site [chemical binding]; other site 1279365002220 catalytic Zn binding site [ion binding]; other site 1279365002221 Ion channel; Region: Ion_trans_2; pfam07885 1279365002222 putative transposase OrfB; Reviewed; Region: PHA02517 1279365002223 HTH-like domain; Region: HTH_21; pfam13276 1279365002224 Integrase core domain; Region: rve; pfam00665 1279365002225 Integrase core domain; Region: rve_2; pfam13333 1279365002226 Transposase; Region: HTH_Tnp_1; cl17663 1279365002227 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1279365002228 Zn binding site [ion binding]; other site 1279365002229 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1279365002230 putative catalytic site [active] 1279365002231 metal binding site A [ion binding]; metal-binding site 1279365002232 phosphate binding site [ion binding]; other site 1279365002233 metal binding site C [ion binding]; metal-binding site 1279365002234 metal binding site B [ion binding]; metal-binding site 1279365002235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365002236 non-specific DNA binding site [nucleotide binding]; other site 1279365002237 salt bridge; other site 1279365002238 sequence-specific DNA binding site [nucleotide binding]; other site 1279365002239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365002240 sequence-specific DNA binding site [nucleotide binding]; other site 1279365002241 salt bridge; other site 1279365002242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365002243 non-specific DNA binding site [nucleotide binding]; other site 1279365002244 salt bridge; other site 1279365002245 sequence-specific DNA binding site [nucleotide binding]; other site 1279365002246 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1279365002247 ORF6C domain; Region: ORF6C; pfam10552 1279365002248 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1279365002249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365002250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365002251 DNA binding residues [nucleotide binding] 1279365002252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1279365002253 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1279365002254 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1279365002255 YjcQ protein; Region: YjcQ; pfam09639 1279365002256 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1279365002257 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1279365002258 Int/Topo IB signature motif; other site 1279365002259 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1279365002260 active site 1279365002261 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1279365002262 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365002263 Phage portal protein; Region: Phage_portal; pfam04860 1279365002264 Phage-related protein [Function unknown]; Region: COG4695 1279365002265 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1279365002266 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1279365002267 oligomer interface [polypeptide binding]; other site 1279365002268 active site residues [active] 1279365002269 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365002270 Phage capsid family; Region: Phage_capsid; pfam05065 1279365002271 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1279365002272 oligomerization interface [polypeptide binding]; other site 1279365002273 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1279365002274 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1279365002275 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1279365002276 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365002277 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365002278 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365002279 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365002280 putative active site [active] 1279365002281 putative NTP binding site [chemical binding]; other site 1279365002282 putative nucleic acid binding site [nucleotide binding]; other site 1279365002283 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365002284 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1279365002285 Phage tail protein; Region: Sipho_tail; pfam05709 1279365002286 Phage tail protein; Region: Sipho_tail; cl17486 1279365002287 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365002288 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1279365002289 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1279365002290 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365002291 active site 1279365002292 catalytic residues [active] 1279365002293 DNA binding site [nucleotide binding] 1279365002294 Int/Topo IB signature motif; other site 1279365002295 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1279365002296 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1279365002297 active site 1279365002298 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1279365002299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1279365002300 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1279365002301 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365002302 Replication-relaxation; Region: Replic_Relax; pfam13814 1279365002303 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365002304 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1279365002305 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1279365002306 dimer interface [polypeptide binding]; other site 1279365002307 active site 1279365002308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1279365002309 substrate binding site [chemical binding]; other site 1279365002310 catalytic residue [active] 1279365002311 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1279365002312 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365002313 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1279365002314 VanZ like family; Region: VanZ; pfam04892 1279365002315 RDD family; Region: RDD; pfam06271 1279365002316 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1279365002317 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365002318 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365002319 dimer interface [polypeptide binding]; other site 1279365002320 putative CheW interface [polypeptide binding]; other site 1279365002321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1279365002322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1279365002323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365002324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365002325 non-specific DNA binding site [nucleotide binding]; other site 1279365002326 salt bridge; other site 1279365002327 sequence-specific DNA binding site [nucleotide binding]; other site 1279365002328 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1279365002329 active site 1279365002330 catalytic site [active] 1279365002331 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1279365002332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002333 POT family; Region: PTR2; cl17359 1279365002334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002335 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1279365002336 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1279365002337 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1279365002338 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1279365002339 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1279365002340 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1279365002341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365002342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365002343 non-specific DNA binding site [nucleotide binding]; other site 1279365002344 salt bridge; other site 1279365002345 sequence-specific DNA binding site [nucleotide binding]; other site 1279365002346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365002347 Coenzyme A binding pocket [chemical binding]; other site 1279365002348 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 1279365002349 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365002350 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1279365002351 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1279365002352 TrkA-N domain; Region: TrkA_N; pfam02254 1279365002353 TrkA-C domain; Region: TrkA_C; pfam02080 1279365002354 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1279365002355 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365002356 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1279365002357 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1279365002358 Subunit I/III interface [polypeptide binding]; other site 1279365002359 Subunit III/IV interface [polypeptide binding]; other site 1279365002360 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1279365002361 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1279365002362 D-pathway; other site 1279365002363 Putative ubiquinol binding site [chemical binding]; other site 1279365002364 Low-spin heme (heme b) binding site [chemical binding]; other site 1279365002365 Putative water exit pathway; other site 1279365002366 Binuclear center (heme o3/CuB) [ion binding]; other site 1279365002367 K-pathway; other site 1279365002368 Putative proton exit pathway; other site 1279365002369 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1279365002370 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1279365002371 S-methylmethionine transporter; Provisional; Region: PRK11387 1279365002372 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1279365002373 putative active site [active] 1279365002374 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1279365002375 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1279365002376 metal binding site [ion binding]; metal-binding site 1279365002377 dimer interface [polypeptide binding]; other site 1279365002378 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1279365002379 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1279365002380 Na binding site [ion binding]; other site 1279365002381 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365002382 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1279365002383 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1279365002384 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365002385 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1279365002386 Nucleoside recognition; Region: Gate; pfam07670 1279365002387 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1279365002388 Nucleoside recognition; Region: Gate; pfam07670 1279365002389 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1279365002390 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1279365002391 G1 box; other site 1279365002392 GTP/Mg2+ binding site [chemical binding]; other site 1279365002393 Switch I region; other site 1279365002394 G2 box; other site 1279365002395 G3 box; other site 1279365002396 Switch II region; other site 1279365002397 G4 box; other site 1279365002398 G5 box; other site 1279365002399 FeoA domain; Region: FeoA; pfam04023 1279365002400 phosphate binding protein; Region: ptsS_2; TIGR02136 1279365002401 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1279365002402 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1279365002403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002404 dimer interface [polypeptide binding]; other site 1279365002405 conserved gate region; other site 1279365002406 putative PBP binding loops; other site 1279365002407 ABC-ATPase subunit interface; other site 1279365002408 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1279365002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002410 dimer interface [polypeptide binding]; other site 1279365002411 conserved gate region; other site 1279365002412 putative PBP binding loops; other site 1279365002413 ABC-ATPase subunit interface; other site 1279365002414 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1279365002415 Protein export membrane protein; Region: SecD_SecF; cl14618 1279365002416 FOG: CBS domain [General function prediction only]; Region: COG0517 1279365002417 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1279365002418 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 1279365002419 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 1279365002420 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365002421 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365002422 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365002423 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365002424 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365002425 Putative transcription activator [Transcription]; Region: TenA; COG0819 1279365002426 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1279365002427 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1279365002428 Walker A/P-loop; other site 1279365002429 ATP binding site [chemical binding]; other site 1279365002430 Q-loop/lid; other site 1279365002431 ABC transporter signature motif; other site 1279365002432 Walker B; other site 1279365002433 D-loop; other site 1279365002434 H-loop/switch region; other site 1279365002435 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1279365002436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002437 dimer interface [polypeptide binding]; other site 1279365002438 conserved gate region; other site 1279365002439 putative PBP binding loops; other site 1279365002440 ABC-ATPase subunit interface; other site 1279365002441 NMT1/THI5 like; Region: NMT1; pfam09084 1279365002442 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1279365002443 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1279365002444 thiamine phosphate binding site [chemical binding]; other site 1279365002445 active site 1279365002446 pyrophosphate binding site [ion binding]; other site 1279365002447 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1279365002448 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1279365002449 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1279365002450 thiS-thiF/thiG interaction site; other site 1279365002451 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1279365002452 ThiS interaction site; other site 1279365002453 putative active site [active] 1279365002454 tetramer interface [polypeptide binding]; other site 1279365002455 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1279365002456 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1279365002457 ATP binding site [chemical binding]; other site 1279365002458 substrate interface [chemical binding]; other site 1279365002459 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1279365002460 dimer interface [polypeptide binding]; other site 1279365002461 substrate binding site [chemical binding]; other site 1279365002462 ATP binding site [chemical binding]; other site 1279365002463 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1279365002464 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1279365002465 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1279365002466 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365002467 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1279365002468 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 1279365002469 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1279365002470 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1279365002471 Ligand Binding Site [chemical binding]; other site 1279365002472 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1279365002473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002474 putative substrate translocation pore; other site 1279365002475 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365002476 MarR family; Region: MarR; pfam01047 1279365002477 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1279365002478 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1279365002479 active site 1279365002480 nucleophile elbow; other site 1279365002481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1279365002482 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365002483 FtsX-like permease family; Region: FtsX; pfam02687 1279365002484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365002485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365002486 Walker A/P-loop; other site 1279365002487 ATP binding site [chemical binding]; other site 1279365002488 Q-loop/lid; other site 1279365002489 ABC transporter signature motif; other site 1279365002490 Walker B; other site 1279365002491 D-loop; other site 1279365002492 H-loop/switch region; other site 1279365002493 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1279365002494 short chain dehydrogenase; Provisional; Region: PRK06701 1279365002495 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1279365002496 NAD binding site [chemical binding]; other site 1279365002497 metal binding site [ion binding]; metal-binding site 1279365002498 active site 1279365002499 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1279365002500 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365002501 catalytic residues [active] 1279365002502 putative disulfide oxidoreductase; Provisional; Region: PRK03113 1279365002503 YhdB-like protein; Region: YhdB; pfam14148 1279365002504 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 1279365002505 Spore germination protein; Region: Spore_permease; pfam03845 1279365002506 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1279365002507 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365002508 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365002509 putative transposase OrfB; Reviewed; Region: PHA02517 1279365002510 HTH-like domain; Region: HTH_21; pfam13276 1279365002511 Integrase core domain; Region: rve; pfam00665 1279365002512 Integrase core domain; Region: rve_2; pfam13333 1279365002513 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1279365002514 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1279365002515 putative FMN binding site [chemical binding]; other site 1279365002516 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1279365002517 SpoVR like protein; Region: SpoVR; pfam04293 1279365002518 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1279365002519 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1279365002520 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1279365002521 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1279365002522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365002523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365002524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1279365002525 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1279365002526 active site residue [active] 1279365002527 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1279365002528 putative homodimer interface [polypeptide binding]; other site 1279365002529 putative homotetramer interface [polypeptide binding]; other site 1279365002530 putative metal binding site [ion binding]; other site 1279365002531 putative homodimer-homodimer interface [polypeptide binding]; other site 1279365002532 putative allosteric switch controlling residues; other site 1279365002533 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1279365002534 CPxP motif; other site 1279365002535 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365002536 active site residue [active] 1279365002537 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 1279365002538 active site residue [active] 1279365002539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365002540 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1279365002541 CPxP motif; other site 1279365002542 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365002543 active site residue [active] 1279365002544 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365002545 active site residue [active] 1279365002546 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1279365002547 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365002548 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1279365002549 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1279365002550 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1279365002551 NADP binding site [chemical binding]; other site 1279365002552 dimer interface [polypeptide binding]; other site 1279365002553 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1279365002554 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1279365002555 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1279365002556 PhoU domain; Region: PhoU; pfam01895 1279365002557 PhoU domain; Region: PhoU; pfam01895 1279365002558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365002560 putative substrate translocation pore; other site 1279365002561 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1279365002562 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1279365002563 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1279365002564 HTH domain; Region: HTH_11; pfam08279 1279365002565 Mga helix-turn-helix domain; Region: Mga; pfam05043 1279365002566 PRD domain; Region: PRD; pfam00874 1279365002567 PRD domain; Region: PRD; pfam00874 1279365002568 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1279365002569 active site 1279365002570 P-loop; other site 1279365002571 phosphorylation site [posttranslational modification] 1279365002572 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1279365002573 active site 1279365002574 phosphorylation site [posttranslational modification] 1279365002575 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1279365002576 active site 1279365002577 methionine cluster; other site 1279365002578 phosphorylation site [posttranslational modification] 1279365002579 metal binding site [ion binding]; metal-binding site 1279365002580 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1279365002581 active site 1279365002582 P-loop; other site 1279365002583 phosphorylation site [posttranslational modification] 1279365002584 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1279365002585 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1279365002586 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1279365002587 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1279365002588 HEAT repeats; Region: HEAT_2; pfam13646 1279365002589 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365002590 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365002591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1279365002592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1279365002593 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365002594 FtsX-like permease family; Region: FtsX; pfam02687 1279365002595 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365002596 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365002597 Walker A/P-loop; other site 1279365002598 ATP binding site [chemical binding]; other site 1279365002599 Q-loop/lid; other site 1279365002600 ABC transporter signature motif; other site 1279365002601 Walker B; other site 1279365002602 D-loop; other site 1279365002603 H-loop/switch region; other site 1279365002604 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1279365002605 HlyD family secretion protein; Region: HlyD_3; pfam13437 1279365002606 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 1279365002607 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1279365002608 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1279365002609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1279365002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002611 dimer interface [polypeptide binding]; other site 1279365002612 conserved gate region; other site 1279365002613 ABC-ATPase subunit interface; other site 1279365002614 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1279365002615 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1279365002616 dimanganese center [ion binding]; other site 1279365002617 CotJB protein; Region: CotJB; pfam12652 1279365002618 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1279365002619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365002620 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365002621 active site 1279365002622 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1279365002623 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1279365002624 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1279365002625 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1279365002626 putative DNA binding site [nucleotide binding]; other site 1279365002627 putative homodimer interface [polypeptide binding]; other site 1279365002628 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1279365002629 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365002630 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1279365002631 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1279365002632 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 1279365002633 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365002634 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1279365002635 active site 1279365002636 metal binding site [ion binding]; metal-binding site 1279365002637 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365002638 Interdomain contacts; other site 1279365002639 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1279365002640 amino acid transporter; Region: 2A0306; TIGR00909 1279365002641 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1279365002642 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1279365002643 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365002644 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1279365002645 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1279365002646 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1279365002647 putative active site [active] 1279365002648 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1279365002649 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1279365002650 putative active site [active] 1279365002651 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1279365002652 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1279365002653 active site turn [active] 1279365002654 phosphorylation site [posttranslational modification] 1279365002655 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1279365002656 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1279365002657 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1279365002658 DoxX; Region: DoxX; pfam07681 1279365002659 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1279365002660 hypothetical protein; Provisional; Region: PRK06770 1279365002661 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365002662 EamA-like transporter family; Region: EamA; pfam00892 1279365002663 EamA-like transporter family; Region: EamA; pfam00892 1279365002664 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1279365002665 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1279365002666 AsnC family; Region: AsnC_trans_reg; pfam01037 1279365002667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365002668 Coenzyme A binding pocket [chemical binding]; other site 1279365002669 short chain dehydrogenase; Provisional; Region: PRK06924 1279365002670 classical (c) SDRs; Region: SDR_c; cd05233 1279365002671 NAD(P) binding site [chemical binding]; other site 1279365002672 active site 1279365002673 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1279365002674 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1279365002675 DNA binding residues [nucleotide binding] 1279365002676 putative dimer interface [polypeptide binding]; other site 1279365002677 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1279365002678 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1279365002679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365002680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365002681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365002682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002684 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365002685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365002686 dimerization interface [polypeptide binding]; other site 1279365002687 putative DNA binding site [nucleotide binding]; other site 1279365002688 putative Zn2+ binding site [ion binding]; other site 1279365002689 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1279365002690 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1279365002691 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1279365002692 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1279365002693 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1279365002694 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1279365002695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365002696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002697 putative substrate translocation pore; other site 1279365002698 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1279365002699 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1279365002700 proposed catalytic triad [active] 1279365002701 conserved cys residue [active] 1279365002702 hydroperoxidase II; Provisional; Region: katE; PRK11249 1279365002703 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1279365002704 tetramer interface [polypeptide binding]; other site 1279365002705 heme binding pocket [chemical binding]; other site 1279365002706 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1279365002707 domain interactions; other site 1279365002708 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1279365002709 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1279365002710 Spore germination protein; Region: Spore_permease; cl17796 1279365002711 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1279365002712 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1279365002713 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1279365002714 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1279365002715 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1279365002716 tetrameric interface [polypeptide binding]; other site 1279365002717 activator binding site; other site 1279365002718 NADP binding site [chemical binding]; other site 1279365002719 substrate binding site [chemical binding]; other site 1279365002720 catalytic residues [active] 1279365002721 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365002722 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1279365002723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365002724 Walker A/P-loop; other site 1279365002725 ATP binding site [chemical binding]; other site 1279365002726 Q-loop/lid; other site 1279365002727 ABC transporter signature motif; other site 1279365002728 Walker B; other site 1279365002729 D-loop; other site 1279365002730 H-loop/switch region; other site 1279365002731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365002732 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1279365002733 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1279365002734 Walker A/P-loop; other site 1279365002735 ATP binding site [chemical binding]; other site 1279365002736 Q-loop/lid; other site 1279365002737 ABC transporter signature motif; other site 1279365002738 Walker B; other site 1279365002739 D-loop; other site 1279365002740 H-loop/switch region; other site 1279365002741 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1279365002742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365002743 substrate binding pocket [chemical binding]; other site 1279365002744 membrane-bound complex binding site; other site 1279365002745 hinge residues; other site 1279365002746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002747 dimer interface [polypeptide binding]; other site 1279365002748 conserved gate region; other site 1279365002749 putative PBP binding loops; other site 1279365002750 ABC-ATPase subunit interface; other site 1279365002751 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1279365002752 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1279365002753 Walker A/P-loop; other site 1279365002754 ATP binding site [chemical binding]; other site 1279365002755 Q-loop/lid; other site 1279365002756 ABC transporter signature motif; other site 1279365002757 Walker B; other site 1279365002758 D-loop; other site 1279365002759 H-loop/switch region; other site 1279365002760 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1279365002761 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1279365002762 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1279365002763 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1279365002764 hypothetical protein; Provisional; Region: PRK13676 1279365002765 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1279365002766 acetolactate synthase; Reviewed; Region: PRK08617 1279365002767 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1279365002768 PYR/PP interface [polypeptide binding]; other site 1279365002769 dimer interface [polypeptide binding]; other site 1279365002770 TPP binding site [chemical binding]; other site 1279365002771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1279365002772 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1279365002773 TPP-binding site [chemical binding]; other site 1279365002774 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1279365002775 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1279365002776 active site 1279365002777 DNA binding site [nucleotide binding] 1279365002778 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1279365002779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1279365002780 active site 1279365002781 motif I; other site 1279365002782 motif II; other site 1279365002783 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1279365002784 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1279365002785 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365002786 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365002787 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365002788 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365002789 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365002790 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365002791 amidase catalytic site [active] 1279365002792 Zn binding residues [ion binding]; other site 1279365002793 substrate binding site [chemical binding]; other site 1279365002794 S-layer homology domain; Region: SLH; pfam00395 1279365002795 S-layer homology domain; Region: SLH; pfam00395 1279365002796 S-layer homology domain; Region: SLH; pfam00395 1279365002797 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1279365002798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365002799 FeS/SAM binding site; other site 1279365002800 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1279365002801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1279365002802 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1279365002803 acyl-activating enzyme (AAE) consensus motif; other site 1279365002804 acyl-activating enzyme (AAE) consensus motif; other site 1279365002805 putative AMP binding site [chemical binding]; other site 1279365002806 putative active site [active] 1279365002807 putative CoA binding site [chemical binding]; other site 1279365002808 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1279365002809 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1279365002810 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1279365002811 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1279365002812 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1279365002813 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1279365002814 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1279365002815 S-layer homology domain; Region: SLH; pfam00395 1279365002816 S-layer homology domain; Region: SLH; pfam00395 1279365002817 S-layer homology domain; Region: SLH; pfam00395 1279365002818 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1279365002819 O-Antigen ligase; Region: Wzy_C; cl04850 1279365002820 enoyl-CoA hydratase; Provisional; Region: PRK07659 1279365002821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1279365002822 substrate binding site [chemical binding]; other site 1279365002823 oxyanion hole (OAH) forming residues; other site 1279365002824 trimer interface [polypeptide binding]; other site 1279365002825 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 1279365002826 metal binding site [ion binding]; metal-binding site 1279365002827 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1279365002828 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1279365002829 putative oligomer interface [polypeptide binding]; other site 1279365002830 putative active site [active] 1279365002831 metal binding site [ion binding]; metal-binding site 1279365002832 S-layer homology domain; Region: SLH; pfam00395 1279365002833 S-layer homology domain; Region: SLH; pfam00395 1279365002834 S-layer homology domain; Region: SLH; pfam00395 1279365002835 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1279365002836 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1279365002837 active site 1279365002838 metal binding site [ion binding]; metal-binding site 1279365002839 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 1279365002840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365002841 S-adenosylmethionine binding site [chemical binding]; other site 1279365002842 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1279365002843 proline racemase; Provisional; Region: PRK13969 1279365002844 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1279365002845 ornithine cyclodeaminase; Validated; Region: PRK08618 1279365002846 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1279365002847 NAD(P) binding site [chemical binding]; other site 1279365002848 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1279365002849 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1279365002850 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1279365002851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002852 dimer interface [polypeptide binding]; other site 1279365002853 conserved gate region; other site 1279365002854 putative PBP binding loops; other site 1279365002855 ABC-ATPase subunit interface; other site 1279365002856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1279365002857 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1279365002858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365002859 dimer interface [polypeptide binding]; other site 1279365002860 conserved gate region; other site 1279365002861 putative PBP binding loops; other site 1279365002862 ABC-ATPase subunit interface; other site 1279365002863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1279365002864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1279365002865 Walker A/P-loop; other site 1279365002866 ATP binding site [chemical binding]; other site 1279365002867 Q-loop/lid; other site 1279365002868 ABC transporter signature motif; other site 1279365002869 Walker B; other site 1279365002870 D-loop; other site 1279365002871 H-loop/switch region; other site 1279365002872 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1279365002873 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1279365002874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1279365002875 Walker A/P-loop; other site 1279365002876 ATP binding site [chemical binding]; other site 1279365002877 Q-loop/lid; other site 1279365002878 ABC transporter signature motif; other site 1279365002879 Walker B; other site 1279365002880 D-loop; other site 1279365002881 H-loop/switch region; other site 1279365002882 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1279365002883 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1279365002884 catalytic site [active] 1279365002885 metal binding site [ion binding]; metal-binding site 1279365002886 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1279365002887 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1279365002888 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1279365002889 catalytic residues [active] 1279365002890 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1279365002891 SnoaL-like domain; Region: SnoaL_2; pfam12680 1279365002892 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1279365002893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365002894 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365002895 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365002896 putative transposase OrfB; Reviewed; Region: PHA02517 1279365002897 HTH-like domain; Region: HTH_21; pfam13276 1279365002898 Integrase core domain; Region: rve; pfam00665 1279365002899 Integrase core domain; Region: rve_2; pfam13333 1279365002900 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1279365002901 ornithine cyclodeaminase; Validated; Region: PRK08618 1279365002902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1279365002903 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1279365002904 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 1279365002905 LXG domain of WXG superfamily; Region: LXG; pfam04740 1279365002906 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1279365002907 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1279365002908 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1279365002909 Yip1 domain; Region: Yip1; pfam04893 1279365002910 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 1279365002911 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1279365002912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002913 putative substrate translocation pore; other site 1279365002914 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1279365002915 PAS domain; Region: PAS; smart00091 1279365002916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365002917 ATP binding site [chemical binding]; other site 1279365002918 Mg2+ binding site [ion binding]; other site 1279365002919 G-X-G motif; other site 1279365002920 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1279365002921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365002922 active site 1279365002923 phosphorylation site [posttranslational modification] 1279365002924 intermolecular recognition site; other site 1279365002925 dimerization interface [polypeptide binding]; other site 1279365002926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1279365002927 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1279365002928 active site 1279365002929 8-oxo-dGMP binding site [chemical binding]; other site 1279365002930 nudix motif; other site 1279365002931 metal binding site [ion binding]; metal-binding site 1279365002932 PLD-like domain; Region: PLDc_2; pfam13091 1279365002933 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1279365002934 putative homodimer interface [polypeptide binding]; other site 1279365002935 putative active site [active] 1279365002936 catalytic site [active] 1279365002937 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1279365002938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365002939 ATP binding site [chemical binding]; other site 1279365002940 putative Mg++ binding site [ion binding]; other site 1279365002941 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1279365002942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365002943 nucleotide binding region [chemical binding]; other site 1279365002944 ATP-binding site [chemical binding]; other site 1279365002945 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1279365002946 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1279365002947 replicative DNA helicase; Provisional; Region: PRK06749 1279365002948 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1279365002949 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1279365002950 Walker A motif; other site 1279365002951 ATP binding site [chemical binding]; other site 1279365002952 Walker B motif; other site 1279365002953 DNA binding loops [nucleotide binding] 1279365002954 hypothetical protein; Provisional; Region: PRK07588 1279365002955 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1279365002956 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365002957 Predicted transcriptional regulators [Transcription]; Region: COG1378 1279365002958 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1279365002959 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1279365002960 C-terminal domain interface [polypeptide binding]; other site 1279365002961 sugar binding site [chemical binding]; other site 1279365002962 hypothetical protein; Provisional; Region: PRK10621 1279365002963 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365002964 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365002965 EamA-like transporter family; Region: EamA; pfam00892 1279365002966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365002967 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1279365002968 Walker A motif; other site 1279365002969 ATP binding site [chemical binding]; other site 1279365002970 Walker B motif; other site 1279365002971 arginine finger; other site 1279365002972 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1279365002973 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1279365002974 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1279365002975 catalytic triad [active] 1279365002976 Predicted membrane protein [Function unknown]; Region: COG1288 1279365002977 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1279365002978 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1279365002979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365002980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365002981 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1279365002982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365002983 putative substrate translocation pore; other site 1279365002984 hypothetical protein; Provisional; Region: PRK06770 1279365002985 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365002986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365002987 putative transposase OrfB; Reviewed; Region: PHA02517 1279365002988 HTH-like domain; Region: HTH_21; pfam13276 1279365002989 Integrase core domain; Region: rve; pfam00665 1279365002990 Integrase core domain; Region: rve_2; pfam13333 1279365002991 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1279365002992 nucleophilic elbow; other site 1279365002993 catalytic triad; other site 1279365002994 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1279365002995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1279365002996 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1279365002997 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1279365002998 YolD-like protein; Region: YolD; pfam08863 1279365002999 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365003000 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365003001 putative active site [active] 1279365003002 putative NTP binding site [chemical binding]; other site 1279365003003 putative nucleic acid binding site [nucleotide binding]; other site 1279365003004 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365003005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365003006 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1279365003007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365003008 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1279365003009 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1279365003010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365003011 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1279365003012 putative DNA binding site [nucleotide binding]; other site 1279365003013 putative Zn2+ binding site [ion binding]; other site 1279365003014 AsnC family; Region: AsnC_trans_reg; pfam01037 1279365003015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365003016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365003017 Coenzyme A binding pocket [chemical binding]; other site 1279365003018 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1279365003019 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1279365003020 dimer interface [polypeptide binding]; other site 1279365003021 active site 1279365003022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003023 salt bridge; other site 1279365003024 non-specific DNA binding site [nucleotide binding]; other site 1279365003025 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003026 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1279365003027 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1279365003028 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1279365003029 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1279365003030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365003031 putative substrate translocation pore; other site 1279365003032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365003033 putative DNA binding site [nucleotide binding]; other site 1279365003034 dimerization interface [polypeptide binding]; other site 1279365003035 putative Zn2+ binding site [ion binding]; other site 1279365003036 VanZ like family; Region: VanZ; pfam04892 1279365003037 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1279365003038 beta-alpha-beta structure motif; other site 1279365003039 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1279365003040 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1279365003041 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 1279365003042 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1279365003043 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1279365003044 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1279365003045 dihydroxyacetone kinase; Provisional; Region: PRK14479 1279365003046 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1279365003047 DAK2 domain; Region: Dak2; pfam02734 1279365003048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365003049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365003050 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1279365003051 Walker A motif; other site 1279365003052 ATP binding site [chemical binding]; other site 1279365003053 Walker B motif; other site 1279365003054 arginine finger; other site 1279365003055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1279365003056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365003057 Integrase core domain; Region: rve; pfam00665 1279365003058 DAK2 domain; Region: Dak2; cl03685 1279365003059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003060 non-specific DNA binding site [nucleotide binding]; other site 1279365003061 salt bridge; other site 1279365003062 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365003064 S-layer homology domain; Region: SLH; pfam00395 1279365003065 S-layer homology domain; Region: SLH; pfam00395 1279365003066 S-layer homology domain; Region: SLH; pfam00395 1279365003067 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1279365003068 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365003069 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365003070 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1279365003071 Putative zinc-finger; Region: zf-HC2; pfam13490 1279365003072 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1279365003073 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1279365003074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365003075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365003076 DNA binding residues [nucleotide binding] 1279365003077 Heat induced stress protein YflT; Region: YflT; pfam11181 1279365003078 Predicted membrane protein [Function unknown]; Region: COG2261 1279365003079 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1279365003080 anti sigma factor interaction site; other site 1279365003081 regulatory phosphorylation site [posttranslational modification]; other site 1279365003082 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1279365003083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365003084 ATP binding site [chemical binding]; other site 1279365003085 Mg2+ binding site [ion binding]; other site 1279365003086 G-X-G motif; other site 1279365003087 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 1279365003088 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365003089 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1279365003090 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365003091 DNA binding residues [nucleotide binding] 1279365003092 Ferritin-like domain; Region: Ferritin; pfam00210 1279365003093 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1279365003094 dinuclear metal binding motif [ion binding]; other site 1279365003095 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1279365003096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365003097 active site 1279365003098 phosphorylation site [posttranslational modification] 1279365003099 intermolecular recognition site; other site 1279365003100 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1279365003101 dimerization interface [polypeptide binding]; other site 1279365003102 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1279365003103 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1279365003104 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1279365003105 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1279365003106 CHASE3 domain; Region: CHASE3; pfam05227 1279365003107 GAF domain; Region: GAF; pfam01590 1279365003108 GAF domain; Region: GAF_2; pfam13185 1279365003109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365003110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365003111 dimer interface [polypeptide binding]; other site 1279365003112 phosphorylation site [posttranslational modification] 1279365003113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365003114 ATP binding site [chemical binding]; other site 1279365003115 Mg2+ binding site [ion binding]; other site 1279365003116 G-X-G motif; other site 1279365003117 Response regulator receiver domain; Region: Response_reg; pfam00072 1279365003118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365003119 active site 1279365003120 phosphorylation site [posttranslational modification] 1279365003121 intermolecular recognition site; other site 1279365003122 dimerization interface [polypeptide binding]; other site 1279365003123 regulatory protein interface [polypeptide binding]; other site 1279365003124 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1279365003125 regulatory phosphorylation site [posttranslational modification]; other site 1279365003126 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 1279365003127 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1279365003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365003129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365003130 putative substrate translocation pore; other site 1279365003131 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1279365003132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365003133 DNA-binding site [nucleotide binding]; DNA binding site 1279365003134 FCD domain; Region: FCD; pfam07729 1279365003135 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1279365003136 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365003137 NADP binding site [chemical binding]; other site 1279365003138 dimer interface [polypeptide binding]; other site 1279365003139 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1279365003140 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1279365003141 active site 1279365003142 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1279365003143 YhzD-like protein; Region: YhzD; pfam14120 1279365003144 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1279365003145 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365003146 active site 1279365003147 metal binding site [ion binding]; metal-binding site 1279365003148 DNA binding site [nucleotide binding] 1279365003149 AAA domain; Region: AAA_27; pfam13514 1279365003150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365003151 Q-loop/lid; other site 1279365003152 ABC transporter signature motif; other site 1279365003153 Walker B; other site 1279365003154 D-loop; other site 1279365003155 H-loop/switch region; other site 1279365003156 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1279365003157 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1279365003158 generic binding surface I; other site 1279365003159 generic binding surface II; other site 1279365003160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365003161 Zn2+ binding site [ion binding]; other site 1279365003162 Mg2+ binding site [ion binding]; other site 1279365003163 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365003164 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365003165 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1279365003166 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365003167 Zn binding site [ion binding]; other site 1279365003168 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1279365003169 Zn binding site [ion binding]; other site 1279365003170 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1279365003171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365003172 Zn binding site [ion binding]; other site 1279365003173 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1279365003174 Zn binding site [ion binding]; other site 1279365003175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365003176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365003177 TPR motif; other site 1279365003178 binding surface 1279365003179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365003180 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1279365003181 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1279365003182 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1279365003183 Cupin; Region: Cupin_1; smart00835 1279365003184 Cupin; Region: Cupin_1; smart00835 1279365003185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003186 non-specific DNA binding site [nucleotide binding]; other site 1279365003187 salt bridge; other site 1279365003188 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003189 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1279365003190 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1279365003191 amphipathic channel; other site 1279365003192 Asn-Pro-Ala signature motifs; other site 1279365003193 glycerol kinase; Provisional; Region: glpK; PRK00047 1279365003194 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1279365003195 N- and C-terminal domain interface [polypeptide binding]; other site 1279365003196 active site 1279365003197 MgATP binding site [chemical binding]; other site 1279365003198 catalytic site [active] 1279365003199 metal binding site [ion binding]; metal-binding site 1279365003200 glycerol binding site [chemical binding]; other site 1279365003201 homotetramer interface [polypeptide binding]; other site 1279365003202 homodimer interface [polypeptide binding]; other site 1279365003203 FBP binding site [chemical binding]; other site 1279365003204 protein IIAGlc interface [polypeptide binding]; other site 1279365003205 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1279365003206 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1279365003207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365003208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365003209 DNA binding residues [nucleotide binding] 1279365003210 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 1279365003211 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365003212 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1279365003213 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1279365003214 Part of AAA domain; Region: AAA_19; pfam13245 1279365003215 Family description; Region: UvrD_C_2; pfam13538 1279365003216 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1279365003217 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1279365003218 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1279365003219 transcriptional regulator Hpr; Provisional; Region: PRK13777 1279365003220 MarR family; Region: MarR; pfam01047 1279365003221 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1279365003222 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1279365003223 HIT family signature motif; other site 1279365003224 catalytic residue [active] 1279365003225 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1279365003226 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365003227 Walker A/P-loop; other site 1279365003228 ATP binding site [chemical binding]; other site 1279365003229 Q-loop/lid; other site 1279365003230 ABC transporter signature motif; other site 1279365003231 Walker B; other site 1279365003232 D-loop; other site 1279365003233 H-loop/switch region; other site 1279365003234 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1279365003235 EcsC protein family; Region: EcsC; pfam12787 1279365003236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365003237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365003238 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1279365003239 Predicted membrane protein [Function unknown]; Region: COG3428 1279365003240 Bacterial PH domain; Region: DUF304; pfam03703 1279365003241 Bacterial PH domain; Region: DUF304; pfam03703 1279365003242 Bacterial PH domain; Region: DUF304; pfam03703 1279365003243 Protein of unknown function (DUF975); Region: DUF975; cl10504 1279365003244 Protein of unknown function (DUF975); Region: DUF975; cl10504 1279365003245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365003246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365003247 Collagen binding domain; Region: Collagen_bind; pfam05737 1279365003248 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365003249 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003250 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003251 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003252 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003253 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003254 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003255 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003256 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003257 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003258 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003259 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003260 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003261 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365003262 Cornifin (SPRR) family; Region: Cornifin; pfam02389 1279365003263 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1279365003264 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1279365003265 classical (c) SDRs; Region: SDR_c; cd05233 1279365003266 NAD(P) binding site [chemical binding]; other site 1279365003267 active site 1279365003268 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365003269 EamA-like transporter family; Region: EamA; pfam00892 1279365003270 EamA-like transporter family; Region: EamA; cl17759 1279365003271 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1279365003272 Predicted membrane protein [Function unknown]; Region: COG3428 1279365003273 Bacterial PH domain; Region: DUF304; pfam03703 1279365003274 Bacterial PH domain; Region: DUF304; pfam03703 1279365003275 Bacterial PH domain; Region: DUF304; pfam03703 1279365003276 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1279365003277 Transglycosylase; Region: Transgly; pfam00912 1279365003278 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1279365003279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365003280 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1279365003281 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1279365003282 substrate binding site [chemical binding]; other site 1279365003283 active site 1279365003284 ferrochelatase; Provisional; Region: PRK12435 1279365003285 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1279365003286 C-terminal domain interface [polypeptide binding]; other site 1279365003287 active site 1279365003288 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1279365003289 active site 1279365003290 N-terminal domain interface [polypeptide binding]; other site 1279365003291 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1279365003292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365003293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365003294 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 1279365003295 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1279365003296 Fn3 associated; Region: Fn3_assoc; pfam13287 1279365003297 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1279365003298 generic binding surface I; other site 1279365003299 generic binding surface II; other site 1279365003300 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1279365003301 putative active site [active] 1279365003302 putative catalytic site [active] 1279365003303 putative Mg binding site IVb [ion binding]; other site 1279365003304 putative phosphate binding site [ion binding]; other site 1279365003305 putative DNA binding site [nucleotide binding]; other site 1279365003306 putative Mg binding site IVa [ion binding]; other site 1279365003307 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1279365003308 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1279365003309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365003310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365003311 Predicted membrane protein [Function unknown]; Region: COG1511 1279365003312 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1279365003313 Predicted membrane protein [Function unknown]; Region: COG1511 1279365003314 Domain of unknown function (DUF3508); Region: DUF3508; pfam12018 1279365003315 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1279365003316 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1279365003317 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1279365003318 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1279365003319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365003320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365003321 Coenzyme A binding pocket [chemical binding]; other site 1279365003322 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365003323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365003324 DNA binding site [nucleotide binding] 1279365003325 domain linker motif; other site 1279365003326 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1279365003327 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365003328 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1279365003329 YhfH-like protein; Region: YhfH; pfam14149 1279365003330 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1279365003331 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1279365003332 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1279365003333 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1279365003334 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1279365003335 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1279365003336 acyl-activating enzyme (AAE) consensus motif; other site 1279365003337 putative AMP binding site [chemical binding]; other site 1279365003338 putative active site [active] 1279365003339 putative CoA binding site [chemical binding]; other site 1279365003340 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1279365003341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365003342 substrate binding pocket [chemical binding]; other site 1279365003343 membrane-bound complex binding site; other site 1279365003344 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1279365003345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365003346 dimer interface [polypeptide binding]; other site 1279365003347 conserved gate region; other site 1279365003348 putative PBP binding loops; other site 1279365003349 ABC-ATPase subunit interface; other site 1279365003350 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1279365003351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365003352 dimer interface [polypeptide binding]; other site 1279365003353 conserved gate region; other site 1279365003354 putative PBP binding loops; other site 1279365003355 ABC-ATPase subunit interface; other site 1279365003356 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1279365003357 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1279365003358 Walker A/P-loop; other site 1279365003359 ATP binding site [chemical binding]; other site 1279365003360 Q-loop/lid; other site 1279365003361 ABC transporter signature motif; other site 1279365003362 Walker B; other site 1279365003363 D-loop; other site 1279365003364 H-loop/switch region; other site 1279365003365 TOBE-like domain; Region: TOBE_3; pfam12857 1279365003366 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1279365003367 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1279365003368 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1279365003369 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1279365003370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365003371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365003372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1279365003373 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1279365003374 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365003375 putative active site [active] 1279365003376 putative metal binding site [ion binding]; other site 1279365003377 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1279365003378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365003379 Zn2+ binding site [ion binding]; other site 1279365003380 Mg2+ binding site [ion binding]; other site 1279365003381 Putative zinc-finger; Region: zf-HC2; pfam13490 1279365003382 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1279365003383 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1279365003384 RNA polymerase sigma factor; Provisional; Region: PRK12541 1279365003385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365003386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365003387 DNA binding residues [nucleotide binding] 1279365003388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365003389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1279365003390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365003391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1279365003392 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1279365003393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365003394 active site 1279365003395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365003396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365003397 ATP binding site [chemical binding]; other site 1279365003398 Mg2+ binding site [ion binding]; other site 1279365003399 G-X-G motif; other site 1279365003400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1279365003401 phosphorylation site [posttranslational modification] 1279365003402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365003403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365003404 active site 1279365003405 phosphorylation site [posttranslational modification] 1279365003406 intermolecular recognition site; other site 1279365003407 dimerization interface [polypeptide binding]; other site 1279365003408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365003409 DNA binding site [nucleotide binding] 1279365003410 CAAX protease self-immunity; Region: Abi; pfam02517 1279365003411 Peptidase family M48; Region: Peptidase_M48; pfam01435 1279365003412 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1279365003413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365003414 dimerization interface [polypeptide binding]; other site 1279365003415 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365003416 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365003417 dimer interface [polypeptide binding]; other site 1279365003418 putative CheW interface [polypeptide binding]; other site 1279365003419 S-layer homology domain; Region: SLH; pfam00395 1279365003420 S-layer homology domain; Region: SLH; pfam00395 1279365003421 S-layer homology domain; Region: SLH; pfam00395 1279365003422 S-layer homology domain; Region: SLH; pfam00395 1279365003423 S-layer homology domain; Region: SLH; pfam00395 1279365003424 S-layer homology domain; Region: SLH; pfam00395 1279365003425 malate synthase A; Region: malate_syn_A; TIGR01344 1279365003426 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1279365003427 active site 1279365003428 isocitrate lyase; Provisional; Region: PRK15063 1279365003429 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1279365003430 tetramer interface [polypeptide binding]; other site 1279365003431 active site 1279365003432 Mg2+/Mn2+ binding site [ion binding]; other site 1279365003433 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365003434 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1279365003435 active site 1279365003436 substrate binding site [chemical binding]; other site 1279365003437 ATP binding site [chemical binding]; other site 1279365003438 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1279365003439 DNA-binding site [nucleotide binding]; DNA binding site 1279365003440 RNA-binding motif; other site 1279365003441 ComK protein; Region: ComK; pfam06338 1279365003442 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1279365003443 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365003444 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1279365003445 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365003446 Catalytic site [active] 1279365003447 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365003448 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1279365003449 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1279365003450 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1279365003451 Part of AAA domain; Region: AAA_19; pfam13245 1279365003452 Family description; Region: UvrD_C_2; pfam13538 1279365003453 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1279365003454 hypothetical protein; Provisional; Region: PRK07758 1279365003455 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365003456 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1279365003457 Spore germination protein GerPC; Region: GerPC; pfam10737 1279365003458 Spore germination protein GerPC; Region: GerPC; pfam10737 1279365003459 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1279365003460 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365003461 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1279365003462 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1279365003463 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1279365003464 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1279365003465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365003466 inhibitor-cofactor binding pocket; inhibition site 1279365003467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365003468 catalytic residue [active] 1279365003469 hypothetical protein; Provisional; Region: PRK13673 1279365003470 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1279365003471 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1279365003472 active site 1279365003473 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1279365003474 dimer interface [polypeptide binding]; other site 1279365003475 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1279365003476 Ligand Binding Site [chemical binding]; other site 1279365003477 Molecular Tunnel; other site 1279365003478 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1279365003479 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1279365003480 catalytic residues [active] 1279365003481 catalytic nucleophile [active] 1279365003482 Recombinase; Region: Recombinase; pfam07508 1279365003483 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1279365003484 SOS regulatory protein LexA; Region: lexA; TIGR00498 1279365003485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003486 non-specific DNA binding site [nucleotide binding]; other site 1279365003487 salt bridge; other site 1279365003488 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003489 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1279365003490 Catalytic site [active] 1279365003491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003492 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365003493 non-specific DNA binding site [nucleotide binding]; other site 1279365003494 salt bridge; other site 1279365003495 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003496 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1279365003497 ORF6C domain; Region: ORF6C; pfam10552 1279365003498 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1279365003499 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1279365003500 galactokinase; Region: PLN02865 1279365003501 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1279365003502 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1279365003503 YopX protein; Region: YopX; pfam09643 1279365003504 Recombination protein U; Region: RecU; pfam03838 1279365003505 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1279365003506 YcfA-like protein; Region: YcfA; pfam07927 1279365003507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365003508 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365003509 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365003510 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1279365003511 active site 1279365003512 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365003513 Phage portal protein; Region: Phage_portal; pfam04860 1279365003514 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1279365003515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365003516 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365003517 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365003518 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1279365003519 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365003520 Phage capsid family; Region: Phage_capsid; pfam05065 1279365003521 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1279365003522 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1279365003523 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365003524 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 1279365003525 membrane protein P6; Region: PHA01399 1279365003526 membrane protein P6; Region: PHA01399 1279365003527 Phage tail protein; Region: Sipho_tail; pfam05709 1279365003528 Phage tail protein; Region: Sipho_tail; cl17486 1279365003529 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365003530 Spindle and kinetochore-associated protein 1, N-terminal domain; Region: SKA1_N; cl08452 1279365003531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365003532 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365003533 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365003534 Holin family; Region: Phage_holin_4; pfam05105 1279365003535 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1279365003536 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365003537 amidase catalytic site [active] 1279365003538 Zn binding residues [ion binding]; other site 1279365003539 substrate binding site [chemical binding]; other site 1279365003540 Bacterial SH3 domain; Region: SH3_3; cl17532 1279365003541 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365003542 Helix-turn-helix domains; Region: HTH; cl00088 1279365003543 ferrochelatase; Provisional; Region: PRK12435 1279365003544 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1279365003545 C-terminal domain interface [polypeptide binding]; other site 1279365003546 active site 1279365003547 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1279365003548 active site 1279365003549 N-terminal domain interface [polypeptide binding]; other site 1279365003550 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1279365003551 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1279365003552 tetramer interface [polypeptide binding]; other site 1279365003553 heme binding pocket [chemical binding]; other site 1279365003554 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1279365003555 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1279365003556 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1279365003557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365003558 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1279365003559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365003560 motif II; other site 1279365003561 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1279365003562 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1279365003563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003564 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003565 salt bridge; other site 1279365003566 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1279365003567 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1279365003568 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1279365003569 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1279365003570 active site 1279365003571 catalytic site [active] 1279365003572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1279365003573 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1279365003574 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1279365003575 S1 domain; Region: S1_2; pfam13509 1279365003576 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1279365003577 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1279365003578 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365003579 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365003580 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365003581 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1279365003582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365003583 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365003584 active site 1279365003585 motif I; other site 1279365003586 motif II; other site 1279365003587 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1279365003588 YjzC-like protein; Region: YjzC; pfam14168 1279365003589 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1279365003590 Clp amino terminal domain; Region: Clp_N; pfam02861 1279365003591 Clp amino terminal domain; Region: Clp_N; pfam02861 1279365003592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365003593 Walker A motif; other site 1279365003594 ATP binding site [chemical binding]; other site 1279365003595 Walker B motif; other site 1279365003596 arginine finger; other site 1279365003597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365003598 Walker A motif; other site 1279365003599 ATP binding site [chemical binding]; other site 1279365003600 Walker B motif; other site 1279365003601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1279365003602 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1279365003603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365003604 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1279365003605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365003606 NAD(P) binding site [chemical binding]; other site 1279365003607 active site 1279365003608 ComZ; Region: ComZ; pfam10815 1279365003609 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1279365003610 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1279365003611 dimer interface [polypeptide binding]; other site 1279365003612 active site 1279365003613 CoA binding pocket [chemical binding]; other site 1279365003614 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1279365003615 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1279365003616 dimer interface [polypeptide binding]; other site 1279365003617 active site 1279365003618 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1279365003619 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1279365003620 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1279365003621 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1279365003622 active site 1279365003623 HIGH motif; other site 1279365003624 dimer interface [polypeptide binding]; other site 1279365003625 KMSKS motif; other site 1279365003626 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1279365003627 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365003628 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365003629 peptide binding site [polypeptide binding]; other site 1279365003630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1279365003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365003632 dimer interface [polypeptide binding]; other site 1279365003633 conserved gate region; other site 1279365003634 putative PBP binding loops; other site 1279365003635 ABC-ATPase subunit interface; other site 1279365003636 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1279365003637 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1279365003638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365003639 dimer interface [polypeptide binding]; other site 1279365003640 conserved gate region; other site 1279365003641 putative PBP binding loops; other site 1279365003642 ABC-ATPase subunit interface; other site 1279365003643 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1279365003644 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1279365003645 Walker A/P-loop; other site 1279365003646 ATP binding site [chemical binding]; other site 1279365003647 Q-loop/lid; other site 1279365003648 ABC transporter signature motif; other site 1279365003649 Walker B; other site 1279365003650 D-loop; other site 1279365003651 H-loop/switch region; other site 1279365003652 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1279365003653 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1279365003654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1279365003655 Walker A/P-loop; other site 1279365003656 ATP binding site [chemical binding]; other site 1279365003657 Q-loop/lid; other site 1279365003658 ABC transporter signature motif; other site 1279365003659 Walker B; other site 1279365003660 D-loop; other site 1279365003661 H-loop/switch region; other site 1279365003662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1279365003663 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1279365003664 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1279365003665 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365003666 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365003667 peptide binding site [polypeptide binding]; other site 1279365003668 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1279365003669 ArsC family; Region: ArsC; pfam03960 1279365003670 putative catalytic residues [active] 1279365003671 thiol/disulfide switch; other site 1279365003672 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1279365003673 adaptor protein; Provisional; Region: PRK02315 1279365003674 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1279365003675 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1279365003676 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1279365003677 putative active site [active] 1279365003678 catalytic site [active] 1279365003679 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1279365003680 putative active site [active] 1279365003681 catalytic site [active] 1279365003682 Competence protein CoiA-like family; Region: CoiA; cl11541 1279365003683 oligoendopeptidase F; Region: pepF; TIGR00181 1279365003684 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1279365003685 active site 1279365003686 Zn binding site [ion binding]; other site 1279365003687 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1279365003688 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1279365003689 catalytic residues [active] 1279365003690 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1279365003691 apolar tunnel; other site 1279365003692 heme binding site [chemical binding]; other site 1279365003693 dimerization interface [polypeptide binding]; other site 1279365003694 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1279365003695 putative active site [active] 1279365003696 putative metal binding residues [ion binding]; other site 1279365003697 signature motif; other site 1279365003698 putative triphosphate binding site [ion binding]; other site 1279365003699 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1279365003700 synthetase active site [active] 1279365003701 NTP binding site [chemical binding]; other site 1279365003702 metal binding site [ion binding]; metal-binding site 1279365003703 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1279365003704 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1279365003705 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1279365003706 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1279365003707 active site 1279365003708 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1279365003709 trimer interface [polypeptide binding]; other site 1279365003710 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1279365003711 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1279365003712 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1279365003713 active site 1279365003714 metal binding site [ion binding]; metal-binding site 1279365003715 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1279365003716 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1279365003717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365003718 active site 1279365003719 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365003720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365003721 S-adenosylmethionine binding site [chemical binding]; other site 1279365003722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1279365003723 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1279365003724 putative metal binding site; other site 1279365003725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365003726 binding surface 1279365003727 TPR motif; other site 1279365003728 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365003729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365003730 S-adenosylmethionine binding site [chemical binding]; other site 1279365003731 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1279365003732 catalytic residues [active] 1279365003733 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1279365003734 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1279365003735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365003736 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1279365003737 active site 1279365003738 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1279365003739 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1279365003740 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1279365003741 NAD binding site [chemical binding]; other site 1279365003742 substrate binding site [chemical binding]; other site 1279365003743 homodimer interface [polypeptide binding]; other site 1279365003744 active site 1279365003745 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1279365003746 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1279365003747 NADP binding site [chemical binding]; other site 1279365003748 active site 1279365003749 putative substrate binding site [chemical binding]; other site 1279365003750 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1279365003751 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1279365003752 NAD binding site [chemical binding]; other site 1279365003753 homotetramer interface [polypeptide binding]; other site 1279365003754 homodimer interface [polypeptide binding]; other site 1279365003755 substrate binding site [chemical binding]; other site 1279365003756 active site 1279365003757 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1279365003758 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1279365003759 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1279365003760 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1279365003761 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1279365003762 Part of AAA domain; Region: AAA_19; pfam13245 1279365003763 Family description; Region: UvrD_C_2; pfam13538 1279365003764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1279365003765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365003766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365003767 Coenzyme A binding pocket [chemical binding]; other site 1279365003768 hypothetical protein; Provisional; Region: PRK13679 1279365003769 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1279365003770 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1279365003771 Putative esterase; Region: Esterase; pfam00756 1279365003772 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365003773 EamA-like transporter family; Region: EamA; pfam00892 1279365003774 EamA-like transporter family; Region: EamA; pfam00892 1279365003775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1279365003776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365003777 ligand binding site [chemical binding]; other site 1279365003778 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1279365003779 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1279365003780 Pectate lyase; Region: Pectate_lyase; pfam03211 1279365003781 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1279365003782 Na binding site [ion binding]; other site 1279365003783 anthranilate synthase component I; Provisional; Region: PRK13570 1279365003784 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1279365003785 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1279365003786 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1279365003787 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1279365003788 glutamine binding [chemical binding]; other site 1279365003789 catalytic triad [active] 1279365003790 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1279365003791 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1279365003792 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1279365003793 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1279365003794 active site 1279365003795 ribulose/triose binding site [chemical binding]; other site 1279365003796 phosphate binding site [ion binding]; other site 1279365003797 substrate (anthranilate) binding pocket [chemical binding]; other site 1279365003798 product (indole) binding pocket [chemical binding]; other site 1279365003799 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1279365003800 active site 1279365003801 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1279365003802 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1279365003803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365003804 catalytic residue [active] 1279365003805 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1279365003806 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1279365003807 substrate binding site [chemical binding]; other site 1279365003808 active site 1279365003809 catalytic residues [active] 1279365003810 heterodimer interface [polypeptide binding]; other site 1279365003811 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 1279365003812 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1279365003813 L-lactate permease; Region: Lactate_perm; cl00701 1279365003814 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1279365003815 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1279365003816 Double zinc ribbon; Region: DZR; pfam12773 1279365003817 Predicted membrane protein [Function unknown]; Region: COG4640 1279365003818 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1279365003819 YARHG domain; Region: YARHG; pfam13308 1279365003820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365003821 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1279365003822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365003823 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1279365003824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365003825 Coenzyme A binding pocket [chemical binding]; other site 1279365003826 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 1279365003827 putative transposase OrfB; Reviewed; Region: PHA02517 1279365003828 HTH-like domain; Region: HTH_21; pfam13276 1279365003829 Integrase core domain; Region: rve; pfam00665 1279365003830 Integrase core domain; Region: rve_2; pfam13333 1279365003831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365003832 S-adenosylmethionine binding site [chemical binding]; other site 1279365003833 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1279365003834 NADPH bind site [chemical binding]; other site 1279365003835 putative FMN binding site [chemical binding]; other site 1279365003836 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1279365003837 putative FMN binding site [chemical binding]; other site 1279365003838 NADPH bind site [chemical binding]; other site 1279365003839 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1279365003840 YcaO-like family; Region: YcaO; pfam02624 1279365003841 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1279365003842 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1279365003843 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1279365003844 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1279365003845 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1279365003846 E3 interaction surface; other site 1279365003847 lipoyl attachment site [posttranslational modification]; other site 1279365003848 e3 binding domain; Region: E3_binding; pfam02817 1279365003849 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1279365003850 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1279365003851 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1279365003852 TPP-binding site [chemical binding]; other site 1279365003853 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1279365003854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003855 salt bridge; other site 1279365003856 non-specific DNA binding site [nucleotide binding]; other site 1279365003857 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003858 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 1279365003859 putative transposase OrfB; Reviewed; Region: PHA02517 1279365003860 HTH-like domain; Region: HTH_21; pfam13276 1279365003861 Integrase core domain; Region: rve; pfam00665 1279365003862 Integrase core domain; Region: rve_2; pfam13333 1279365003863 Transposase; Region: HTH_Tnp_1; cl17663 1279365003864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365003865 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1279365003866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365003867 Walker A/P-loop; other site 1279365003868 ATP binding site [chemical binding]; other site 1279365003869 Q-loop/lid; other site 1279365003870 ABC transporter signature motif; other site 1279365003871 Walker B; other site 1279365003872 D-loop; other site 1279365003873 H-loop/switch region; other site 1279365003874 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1279365003875 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1279365003876 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1279365003877 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1279365003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365003879 S-adenosylmethionine binding site [chemical binding]; other site 1279365003880 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1279365003881 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365003882 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1279365003883 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1279365003884 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365003885 Catalytic site [active] 1279365003886 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1279365003887 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 1279365003888 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 1279365003889 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365003890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365003891 non-specific DNA binding site [nucleotide binding]; other site 1279365003892 salt bridge; other site 1279365003893 sequence-specific DNA binding site [nucleotide binding]; other site 1279365003894 Anti-repressor SinI; Region: SinI; pfam08671 1279365003895 Anti-repressor SinI; Region: SinI; pfam08671 1279365003896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1279365003897 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1279365003898 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1279365003899 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1279365003900 NAD(P) binding site [chemical binding]; other site 1279365003901 catalytic residues [active] 1279365003902 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1279365003903 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1279365003904 Walker A/P-loop; other site 1279365003905 ATP binding site [chemical binding]; other site 1279365003906 Q-loop/lid; other site 1279365003907 ABC transporter signature motif; other site 1279365003908 Walker B; other site 1279365003909 D-loop; other site 1279365003910 H-loop/switch region; other site 1279365003911 TOBE domain; Region: TOBE_2; pfam08402 1279365003912 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1279365003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365003914 dimer interface [polypeptide binding]; other site 1279365003915 conserved gate region; other site 1279365003916 putative PBP binding loops; other site 1279365003917 ABC-ATPase subunit interface; other site 1279365003918 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1279365003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365003920 dimer interface [polypeptide binding]; other site 1279365003921 conserved gate region; other site 1279365003922 putative PBP binding loops; other site 1279365003923 ABC-ATPase subunit interface; other site 1279365003924 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1279365003925 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1279365003926 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1279365003927 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1279365003928 active site 1279365003929 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1279365003930 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1279365003931 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1279365003932 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1279365003933 active site 1279365003934 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1279365003935 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1279365003936 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1279365003937 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1279365003938 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1279365003939 Cysteine-rich domain; Region: CCG; pfam02754 1279365003940 Cysteine-rich domain; Region: CCG; pfam02754 1279365003941 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365003942 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1279365003943 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1279365003944 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1279365003945 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1279365003946 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365003947 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365003948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365003949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365003950 active site 1279365003951 phosphorylation site [posttranslational modification] 1279365003952 intermolecular recognition site; other site 1279365003953 dimerization interface [polypeptide binding]; other site 1279365003954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365003955 DNA binding site [nucleotide binding] 1279365003956 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1279365003957 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365003958 dimerization interface [polypeptide binding]; other site 1279365003959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365003960 dimer interface [polypeptide binding]; other site 1279365003961 phosphorylation site [posttranslational modification] 1279365003962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365003963 ATP binding site [chemical binding]; other site 1279365003964 Mg2+ binding site [ion binding]; other site 1279365003965 G-X-G motif; other site 1279365003966 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1279365003967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365003968 DNA-binding site [nucleotide binding]; DNA binding site 1279365003969 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1279365003970 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1279365003971 Cysteine-rich domain; Region: CCG; pfam02754 1279365003972 Cysteine-rich domain; Region: CCG; pfam02754 1279365003973 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1279365003974 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1279365003975 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1279365003976 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1279365003977 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1279365003978 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1279365003979 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1279365003980 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1279365003981 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1279365003982 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1279365003983 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1279365003984 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1279365003985 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1279365003986 dimer interaction site [polypeptide binding]; other site 1279365003987 substrate-binding tunnel; other site 1279365003988 active site 1279365003989 catalytic site [active] 1279365003990 substrate binding site [chemical binding]; other site 1279365003991 polyhydroxyalkanoic acid inclusion protein PhaP; Region: phaP_Bmeg; TIGR02131 1279365003992 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 1279365003993 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365003994 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 1279365003995 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 1279365003996 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1279365003997 NAD(P) binding site [chemical binding]; other site 1279365003998 homotetramer interface [polypeptide binding]; other site 1279365003999 homodimer interface [polypeptide binding]; other site 1279365004000 active site 1279365004001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365004002 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365004003 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365004004 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1279365004005 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1279365004006 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1279365004007 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1279365004008 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1279365004009 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1279365004010 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1279365004011 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 1279365004012 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1279365004013 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1279365004014 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1279365004015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365004016 Walker A/P-loop; other site 1279365004017 ATP binding site [chemical binding]; other site 1279365004018 Q-loop/lid; other site 1279365004019 ABC transporter signature motif; other site 1279365004020 Walker B; other site 1279365004021 D-loop; other site 1279365004022 H-loop/switch region; other site 1279365004023 TOBE domain; Region: TOBE_2; pfam08402 1279365004024 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1279365004025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365004026 dimer interface [polypeptide binding]; other site 1279365004027 conserved gate region; other site 1279365004028 putative PBP binding loops; other site 1279365004029 ABC-ATPase subunit interface; other site 1279365004030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365004031 dimer interface [polypeptide binding]; other site 1279365004032 conserved gate region; other site 1279365004033 putative PBP binding loops; other site 1279365004034 ABC-ATPase subunit interface; other site 1279365004035 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1279365004036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365004037 motif II; other site 1279365004038 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1279365004039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365004040 catalytic residue [active] 1279365004041 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1279365004042 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1279365004043 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1279365004044 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1279365004045 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365004046 heme-binding site [chemical binding]; other site 1279365004047 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004048 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1279365004049 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004050 Leucine-rich repeats; other site 1279365004051 Substrate binding site [chemical binding]; other site 1279365004052 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004053 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004054 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004055 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004056 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004057 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004058 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1279365004059 LRR adjacent; Region: LRR_adjacent; pfam08191 1279365004060 S-layer homology domain; Region: SLH; pfam00395 1279365004061 S-layer homology domain; Region: SLH; pfam00395 1279365004062 S-layer homology domain; Region: SLH; pfam00395 1279365004063 hypothetical protein; Validated; Region: PRK06755 1279365004064 intersubunit interface [polypeptide binding]; other site 1279365004065 active site 1279365004066 Zn2+ binding site [ion binding]; other site 1279365004067 FOG: CBS domain [General function prediction only]; Region: COG0517 1279365004068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1279365004069 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1279365004070 NodB motif; other site 1279365004071 putative active site [active] 1279365004072 putative catalytic site [active] 1279365004073 Zn binding site [ion binding]; other site 1279365004074 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1279365004075 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 1279365004076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365004077 dimer interface [polypeptide binding]; other site 1279365004078 phosphorylation site [posttranslational modification] 1279365004079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004080 ATP binding site [chemical binding]; other site 1279365004081 Mg2+ binding site [ion binding]; other site 1279365004082 G-X-G motif; other site 1279365004083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365004084 MarR family; Region: MarR; pfam01047 1279365004085 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1279365004086 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1279365004087 active site 1279365004088 Zn binding site [ion binding]; other site 1279365004089 DinB superfamily; Region: DinB_2; pfam12867 1279365004090 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1279365004091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365004092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365004093 dimer interface [polypeptide binding]; other site 1279365004094 phosphorylation site [posttranslational modification] 1279365004095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004096 ATP binding site [chemical binding]; other site 1279365004097 Mg2+ binding site [ion binding]; other site 1279365004098 G-X-G motif; other site 1279365004099 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1279365004100 Ligand Binding Site [chemical binding]; other site 1279365004101 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1279365004102 active site 1279365004103 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1279365004104 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1279365004105 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1279365004106 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 1279365004107 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1279365004108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365004109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365004110 Coenzyme A binding pocket [chemical binding]; other site 1279365004111 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1279365004112 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1279365004113 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1279365004114 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1279365004115 active site 1279365004116 dimer interface [polypeptide binding]; other site 1279365004117 catalytic residues [active] 1279365004118 effector binding site; other site 1279365004119 R2 peptide binding site; other site 1279365004120 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1279365004121 dimer interface [polypeptide binding]; other site 1279365004122 putative radical transfer pathway; other site 1279365004123 diiron center [ion binding]; other site 1279365004124 tyrosyl radical; other site 1279365004125 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1279365004126 Predicted transcriptional regulators [Transcription]; Region: COG1725 1279365004127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365004128 DNA-binding site [nucleotide binding]; DNA binding site 1279365004129 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1279365004130 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365004131 Walker A/P-loop; other site 1279365004132 ATP binding site [chemical binding]; other site 1279365004133 Q-loop/lid; other site 1279365004134 ABC transporter signature motif; other site 1279365004135 Walker B; other site 1279365004136 D-loop; other site 1279365004137 H-loop/switch region; other site 1279365004138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365004139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365004140 Walker A/P-loop; other site 1279365004141 ATP binding site [chemical binding]; other site 1279365004142 Q-loop/lid; other site 1279365004143 ABC transporter signature motif; other site 1279365004144 Walker B; other site 1279365004145 D-loop; other site 1279365004146 H-loop/switch region; other site 1279365004147 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1279365004148 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1279365004149 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1279365004150 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 1279365004151 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1279365004152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365004153 putative DNA binding site [nucleotide binding]; other site 1279365004154 putative Zn2+ binding site [ion binding]; other site 1279365004155 AsnC family; Region: AsnC_trans_reg; pfam01037 1279365004156 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1279365004157 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365004158 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1279365004159 catalytic triad [active] 1279365004160 conserved cis-peptide bond; other site 1279365004161 SseB protein; Region: SseB; cl06279 1279365004162 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1279365004163 dimer interface [polypeptide binding]; other site 1279365004164 catalytic triad [active] 1279365004165 Nitronate monooxygenase; Region: NMO; pfam03060 1279365004166 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1279365004167 FMN binding site [chemical binding]; other site 1279365004168 substrate binding site [chemical binding]; other site 1279365004169 putative catalytic residue [active] 1279365004170 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1279365004171 DltD N-terminal region; Region: DltD_N; pfam04915 1279365004172 DltD central region; Region: DltD_M; pfam04918 1279365004173 DltD C-terminal region; Region: DltD_C; pfam04914 1279365004174 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1279365004175 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1279365004176 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1279365004177 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1279365004178 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1279365004179 acyl-activating enzyme (AAE) consensus motif; other site 1279365004180 AMP binding site [chemical binding]; other site 1279365004181 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1279365004182 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1279365004183 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1279365004184 metal binding site [ion binding]; metal-binding site 1279365004185 dimer interface [polypeptide binding]; other site 1279365004186 flavodoxin; Provisional; Region: PRK06756 1279365004187 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1279365004188 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365004189 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365004190 active site 1279365004191 substrate binding site [chemical binding]; other site 1279365004192 ATP binding site [chemical binding]; other site 1279365004193 multidrug efflux protein; Reviewed; Region: PRK01766 1279365004194 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1279365004195 cation binding site [ion binding]; other site 1279365004196 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1279365004197 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365004198 catalytic residues [active] 1279365004199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365004200 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1279365004201 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1279365004202 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1279365004203 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1279365004204 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1279365004205 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1279365004206 hypothetical protein; Provisional; Region: PRK03094 1279365004207 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 1279365004208 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1279365004209 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1279365004210 homodimer interface [polypeptide binding]; other site 1279365004211 substrate-cofactor binding pocket; other site 1279365004212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365004213 catalytic residue [active] 1279365004214 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1279365004215 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1279365004216 PYR/PP interface [polypeptide binding]; other site 1279365004217 dimer interface [polypeptide binding]; other site 1279365004218 TPP binding site [chemical binding]; other site 1279365004219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1279365004220 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1279365004221 TPP-binding site [chemical binding]; other site 1279365004222 dimer interface [polypeptide binding]; other site 1279365004223 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1279365004224 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1279365004225 putative valine binding site [chemical binding]; other site 1279365004226 dimer interface [polypeptide binding]; other site 1279365004227 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1279365004228 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1279365004229 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1279365004230 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1279365004231 2-isopropylmalate synthase; Validated; Region: PRK00915 1279365004232 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1279365004233 active site 1279365004234 catalytic residues [active] 1279365004235 metal binding site [ion binding]; metal-binding site 1279365004236 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1279365004237 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1279365004238 tartrate dehydrogenase; Region: TTC; TIGR02089 1279365004239 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1279365004240 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1279365004241 substrate binding site [chemical binding]; other site 1279365004242 ligand binding site [chemical binding]; other site 1279365004243 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1279365004244 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1279365004245 substrate binding site [chemical binding]; other site 1279365004246 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1279365004247 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1279365004248 dimer interface [polypeptide binding]; other site 1279365004249 motif 1; other site 1279365004250 active site 1279365004251 motif 2; other site 1279365004252 motif 3; other site 1279365004253 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1279365004254 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1279365004255 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1279365004256 histidinol dehydrogenase; Region: hisD; TIGR00069 1279365004257 NAD binding site [chemical binding]; other site 1279365004258 dimerization interface [polypeptide binding]; other site 1279365004259 product binding site; other site 1279365004260 substrate binding site [chemical binding]; other site 1279365004261 zinc binding site [ion binding]; other site 1279365004262 catalytic residues [active] 1279365004263 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1279365004264 putative active site pocket [active] 1279365004265 4-fold oligomerization interface [polypeptide binding]; other site 1279365004266 metal binding residues [ion binding]; metal-binding site 1279365004267 3-fold/trimer interface [polypeptide binding]; other site 1279365004268 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1279365004269 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1279365004270 putative active site [active] 1279365004271 oxyanion strand; other site 1279365004272 catalytic triad [active] 1279365004273 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1279365004274 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1279365004275 catalytic residues [active] 1279365004276 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1279365004277 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1279365004278 substrate binding site [chemical binding]; other site 1279365004279 glutamase interaction surface [polypeptide binding]; other site 1279365004280 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1279365004281 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1279365004282 metal binding site [ion binding]; metal-binding site 1279365004283 histidinol-phosphatase; Validated; Region: PRK06740 1279365004284 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1279365004285 dimer interface [polypeptide binding]; other site 1279365004286 active site 1279365004287 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1279365004288 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1279365004289 putative ligand binding site [chemical binding]; other site 1279365004290 putative NAD binding site [chemical binding]; other site 1279365004291 catalytic site [active] 1279365004292 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1279365004293 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1279365004294 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1279365004295 Sulfatase; Region: Sulfatase; pfam00884 1279365004296 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1279365004297 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1279365004298 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1279365004299 active site 1279365004300 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1279365004301 substrate binding site [chemical binding]; other site 1279365004302 catalytic residues [active] 1279365004303 dimer interface [polypeptide binding]; other site 1279365004304 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 1279365004305 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1279365004306 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1279365004307 Active Sites [active] 1279365004308 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1279365004309 ATP-sulfurylase; Region: ATPS; cd00517 1279365004310 active site 1279365004311 HXXH motif; other site 1279365004312 flexible loop; other site 1279365004313 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1279365004314 AAA domain; Region: AAA_18; pfam13238 1279365004315 ligand-binding site [chemical binding]; other site 1279365004316 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1279365004317 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1279365004318 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1279365004319 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 1279365004320 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1279365004321 active site 1279365004322 SAM binding site [chemical binding]; other site 1279365004323 homodimer interface [polypeptide binding]; other site 1279365004324 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1279365004325 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1279365004326 putative active site [active] 1279365004327 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1279365004328 putative active site [active] 1279365004329 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1279365004330 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1279365004331 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1279365004332 Na2 binding site [ion binding]; other site 1279365004333 putative substrate binding site 1 [chemical binding]; other site 1279365004334 Na binding site 1 [ion binding]; other site 1279365004335 putative substrate binding site 2 [chemical binding]; other site 1279365004336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1279365004337 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365004338 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365004339 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1279365004340 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1279365004341 Protein of unknown function (DUF402); Region: DUF402; cl00979 1279365004342 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1279365004343 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1279365004344 Vpu protein; Region: Vpu; pfam00558 1279365004345 PspA/IM30 family; Region: PspA_IM30; pfam04012 1279365004346 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1279365004347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365004348 Histidine kinase; Region: HisKA_3; pfam07730 1279365004349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004350 ATP binding site [chemical binding]; other site 1279365004351 Mg2+ binding site [ion binding]; other site 1279365004352 G-X-G motif; other site 1279365004353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365004355 active site 1279365004356 phosphorylation site [posttranslational modification] 1279365004357 intermolecular recognition site; other site 1279365004358 dimerization interface [polypeptide binding]; other site 1279365004359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365004360 DNA binding residues [nucleotide binding] 1279365004361 dimerization interface [polypeptide binding]; other site 1279365004362 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1279365004363 E3 interaction surface; other site 1279365004364 lipoyl attachment site [posttranslational modification]; other site 1279365004365 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1279365004366 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1279365004367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365004368 S-adenosylmethionine binding site [chemical binding]; other site 1279365004369 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1279365004370 Peptidase family M50; Region: Peptidase_M50; pfam02163 1279365004371 active site 1279365004372 putative substrate binding region [chemical binding]; other site 1279365004373 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1279365004374 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1279365004375 heme-binding site [chemical binding]; other site 1279365004376 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1279365004377 FAD binding pocket [chemical binding]; other site 1279365004378 FAD binding motif [chemical binding]; other site 1279365004379 phosphate binding motif [ion binding]; other site 1279365004380 beta-alpha-beta structure motif; other site 1279365004381 NAD binding pocket [chemical binding]; other site 1279365004382 Heme binding pocket [chemical binding]; other site 1279365004383 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1279365004384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365004385 ligand binding site [chemical binding]; other site 1279365004386 flexible hinge region; other site 1279365004387 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1279365004388 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365004389 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1279365004390 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1279365004391 Transglycosylase; Region: Transgly; pfam00912 1279365004392 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1279365004393 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365004394 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1279365004395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365004396 dimer interface [polypeptide binding]; other site 1279365004397 phosphorylation site [posttranslational modification] 1279365004398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004399 ATP binding site [chemical binding]; other site 1279365004400 Mg2+ binding site [ion binding]; other site 1279365004401 G-X-G motif; other site 1279365004402 Protein of unknown function DUF72; Region: DUF72; pfam01904 1279365004403 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 1279365004404 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365004405 active site 1279365004406 DNA binding site [nucleotide binding] 1279365004407 Int/Topo IB signature motif; other site 1279365004408 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365004409 dimerization interface [polypeptide binding]; other site 1279365004410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365004411 dimer interface [polypeptide binding]; other site 1279365004412 phosphorylation site [posttranslational modification] 1279365004413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004414 ATP binding site [chemical binding]; other site 1279365004415 Mg2+ binding site [ion binding]; other site 1279365004416 G-X-G motif; other site 1279365004417 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1279365004418 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1279365004419 Predicted integral membrane protein [Function unknown]; Region: COG0392 1279365004420 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1279365004421 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1279365004422 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1279365004423 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1279365004424 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1279365004425 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1279365004426 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365004427 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1279365004428 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1279365004429 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1279365004430 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1279365004431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365004432 RNA binding surface [nucleotide binding]; other site 1279365004433 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1279365004434 active site 1279365004435 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1279365004436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1279365004437 catalytic residues [active] 1279365004438 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1279365004439 ResB-like family; Region: ResB; pfam05140 1279365004440 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1279365004441 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1279365004442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365004443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365004444 active site 1279365004445 phosphorylation site [posttranslational modification] 1279365004446 intermolecular recognition site; other site 1279365004447 dimerization interface [polypeptide binding]; other site 1279365004448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365004449 DNA binding site [nucleotide binding] 1279365004450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365004451 dimerization interface [polypeptide binding]; other site 1279365004452 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1279365004453 PAS domain; Region: PAS; smart00091 1279365004454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365004455 dimer interface [polypeptide binding]; other site 1279365004456 phosphorylation site [posttranslational modification] 1279365004457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004458 ATP binding site [chemical binding]; other site 1279365004459 Mg2+ binding site [ion binding]; other site 1279365004460 G-X-G motif; other site 1279365004461 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1279365004462 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365004463 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365004464 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1279365004465 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365004466 Predicted membrane protein [Function unknown]; Region: COG3601 1279365004467 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1279365004468 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1279365004469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1279365004470 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1279365004471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365004472 ATP binding site [chemical binding]; other site 1279365004473 putative Mg++ binding site [ion binding]; other site 1279365004474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365004475 nucleotide binding region [chemical binding]; other site 1279365004476 ATP-binding site [chemical binding]; other site 1279365004477 CAAX protease self-immunity; Region: Abi; pfam02517 1279365004478 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365004479 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1279365004480 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365004481 putative active site [active] 1279365004482 putative metal binding site [ion binding]; other site 1279365004483 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365004484 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1279365004485 DNA binding residues [nucleotide binding] 1279365004486 B12 binding domain; Region: B12-binding_2; pfam02607 1279365004487 adaptor protein; Provisional; Region: PRK02899 1279365004488 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1279365004489 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1279365004490 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1279365004491 NAD(P) binding site [chemical binding]; other site 1279365004492 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 1279365004493 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365004494 amidase catalytic site [active] 1279365004495 Zn binding residues [ion binding]; other site 1279365004496 substrate binding site [chemical binding]; other site 1279365004497 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1279365004498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1279365004499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365004500 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1279365004501 active site 1279365004502 homodimer interface [polypeptide binding]; other site 1279365004503 homotetramer interface [polypeptide binding]; other site 1279365004504 cytidylate kinase; Provisional; Region: cmk; PRK00023 1279365004505 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1279365004506 CMP-binding site; other site 1279365004507 The sites determining sugar specificity; other site 1279365004508 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1279365004509 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1279365004510 RNA binding site [nucleotide binding]; other site 1279365004511 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1279365004512 RNA binding site [nucleotide binding]; other site 1279365004513 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1279365004514 RNA binding site [nucleotide binding]; other site 1279365004515 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1279365004516 RNA binding site [nucleotide binding]; other site 1279365004517 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1279365004518 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1279365004519 homotetramer interface [polypeptide binding]; other site 1279365004520 FMN binding site [chemical binding]; other site 1279365004521 homodimer contacts [polypeptide binding]; other site 1279365004522 putative active site [active] 1279365004523 putative substrate binding site [chemical binding]; other site 1279365004524 YpzI-like protein; Region: YpzI; pfam14140 1279365004525 YIEGIA protein; Region: YIEGIA; pfam14045 1279365004526 GTP-binding protein Der; Reviewed; Region: PRK00093 1279365004527 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1279365004528 G1 box; other site 1279365004529 GTP/Mg2+ binding site [chemical binding]; other site 1279365004530 Switch I region; other site 1279365004531 G2 box; other site 1279365004532 Switch II region; other site 1279365004533 G3 box; other site 1279365004534 G4 box; other site 1279365004535 G5 box; other site 1279365004536 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1279365004537 G1 box; other site 1279365004538 GTP/Mg2+ binding site [chemical binding]; other site 1279365004539 Switch I region; other site 1279365004540 G2 box; other site 1279365004541 G3 box; other site 1279365004542 Switch II region; other site 1279365004543 G4 box; other site 1279365004544 G5 box; other site 1279365004545 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1279365004546 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1279365004547 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1279365004548 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1279365004549 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1279365004550 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1279365004551 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1279365004552 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1279365004553 IHF dimer interface [polypeptide binding]; other site 1279365004554 IHF - DNA interface [nucleotide binding]; other site 1279365004555 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1279365004556 homodecamer interface [polypeptide binding]; other site 1279365004557 GTP cyclohydrolase I; Provisional; Region: PLN03044 1279365004558 active site 1279365004559 putative catalytic site residues [active] 1279365004560 zinc binding site [ion binding]; other site 1279365004561 GTP-CH-I/GFRP interaction surface; other site 1279365004562 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1279365004563 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1279365004564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365004565 S-adenosylmethionine binding site [chemical binding]; other site 1279365004566 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1279365004567 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1279365004568 substrate binding pocket [chemical binding]; other site 1279365004569 chain length determination region; other site 1279365004570 substrate-Mg2+ binding site; other site 1279365004571 catalytic residues [active] 1279365004572 aspartate-rich region 1; other site 1279365004573 active site lid residues [active] 1279365004574 aspartate-rich region 2; other site 1279365004575 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1279365004576 active site 1279365004577 multimer interface [polypeptide binding]; other site 1279365004578 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1279365004579 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1279365004580 Tetramer interface [polypeptide binding]; other site 1279365004581 active site 1279365004582 FMN-binding site [chemical binding]; other site 1279365004583 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1279365004584 active site 1279365004585 dimer interface [polypeptide binding]; other site 1279365004586 metal binding site [ion binding]; metal-binding site 1279365004587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365004588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365004589 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1279365004590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365004591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365004592 homodimer interface [polypeptide binding]; other site 1279365004593 catalytic residue [active] 1279365004594 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365004595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365004596 binding surface 1279365004597 TPR motif; other site 1279365004598 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1279365004599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365004600 binding surface 1279365004601 TPR motif; other site 1279365004602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365004603 binding surface 1279365004604 TPR motif; other site 1279365004605 hypothetical protein; Provisional; Region: PRK03636 1279365004606 UPF0302 domain; Region: UPF0302; pfam08864 1279365004607 IDEAL domain; Region: IDEAL; pfam08858 1279365004608 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1279365004609 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1279365004610 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1279365004611 iron-sulfur cluster [ion binding]; other site 1279365004612 [2Fe-2S] cluster binding site [ion binding]; other site 1279365004613 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1279365004614 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1279365004615 interchain domain interface [polypeptide binding]; other site 1279365004616 intrachain domain interface; other site 1279365004617 heme bH binding site [chemical binding]; other site 1279365004618 Qi binding site; other site 1279365004619 heme bL binding site [chemical binding]; other site 1279365004620 Qo binding site; other site 1279365004621 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1279365004622 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1279365004623 interchain domain interface [polypeptide binding]; other site 1279365004624 intrachain domain interface; other site 1279365004625 Qi binding site; other site 1279365004626 Qo binding site; other site 1279365004627 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1279365004628 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1279365004629 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 1279365004630 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1279365004631 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1279365004632 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1279365004633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365004634 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365004635 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365004636 putative transposase OrfB; Reviewed; Region: PHA02517 1279365004637 HTH-like domain; Region: HTH_21; pfam13276 1279365004638 Integrase core domain; Region: rve; pfam00665 1279365004639 Integrase core domain; Region: rve_2; pfam13333 1279365004640 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1279365004641 active site 1279365004642 Fe-S cluster binding site [ion binding]; other site 1279365004643 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1279365004644 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365004645 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365004646 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365004647 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365004648 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1279365004649 homodimer interface [polypeptide binding]; other site 1279365004650 metal binding site [ion binding]; metal-binding site 1279365004651 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1279365004652 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1279365004653 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1279365004654 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1279365004655 active site 1279365004656 dimer interfaces [polypeptide binding]; other site 1279365004657 catalytic residues [active] 1279365004658 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1279365004659 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1279365004660 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1279365004661 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1279365004662 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1279365004663 active site 1279365004664 NTP binding site [chemical binding]; other site 1279365004665 metal binding triad [ion binding]; metal-binding site 1279365004666 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1279365004667 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1279365004668 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1279365004669 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1279365004670 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1279365004671 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1279365004672 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1279365004673 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1279365004674 oligomerization interface [polypeptide binding]; other site 1279365004675 active site 1279365004676 metal binding site [ion binding]; metal-binding site 1279365004677 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1279365004678 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1279365004679 active site 1279365004680 ATP-binding site [chemical binding]; other site 1279365004681 pantoate-binding site; other site 1279365004682 HXXH motif; other site 1279365004683 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1279365004684 tetramerization interface [polypeptide binding]; other site 1279365004685 active site 1279365004686 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1279365004687 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1279365004688 active site 1279365004689 catalytic site [active] 1279365004690 substrate binding site [chemical binding]; other site 1279365004691 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1279365004692 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1279365004693 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1279365004694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1279365004695 aspartate aminotransferase; Provisional; Region: PRK05764 1279365004696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365004697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365004698 homodimer interface [polypeptide binding]; other site 1279365004699 catalytic residue [active] 1279365004700 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1279365004701 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1279365004702 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1279365004703 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1279365004704 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1279365004705 minor groove reading motif; other site 1279365004706 helix-hairpin-helix signature motif; other site 1279365004707 substrate binding pocket [chemical binding]; other site 1279365004708 active site 1279365004709 Transglycosylase; Region: Transgly; pfam00912 1279365004710 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1279365004711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365004712 Fibronectin type III domain; Region: fn3; pfam00041 1279365004713 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1279365004714 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1279365004715 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1279365004716 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1279365004717 YppF-like protein; Region: YppF; pfam14178 1279365004718 YppG-like protein; Region: YppG; pfam14179 1279365004719 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1279365004720 hypothetical protein; Provisional; Region: PRK13660 1279365004721 cell division protein GpsB; Provisional; Region: PRK14127 1279365004722 DivIVA domain; Region: DivI1A_domain; TIGR03544 1279365004723 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1279365004724 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1279365004725 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1279365004726 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 1279365004727 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1279365004728 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1279365004729 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1279365004730 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1279365004731 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1279365004732 active site 1279365004733 Zn binding site [ion binding]; other site 1279365004734 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365004735 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365004736 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1279365004737 active site 1279365004738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365004739 active site 1279365004740 xanthine permease; Region: pbuX; TIGR03173 1279365004741 Predicted membrane protein [Function unknown]; Region: COG2311 1279365004742 Protein of unknown function (DUF418); Region: DUF418; cl12135 1279365004743 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1279365004744 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1279365004745 Dynamin family; Region: Dynamin_N; pfam00350 1279365004746 G1 box; other site 1279365004747 GTP/Mg2+ binding site [chemical binding]; other site 1279365004748 G2 box; other site 1279365004749 Switch I region; other site 1279365004750 G3 box; other site 1279365004751 Switch II region; other site 1279365004752 G4 box; other site 1279365004753 G5 box; other site 1279365004754 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1279365004755 Dynamin family; Region: Dynamin_N; pfam00350 1279365004756 G1 box; other site 1279365004757 GTP/Mg2+ binding site [chemical binding]; other site 1279365004758 G2 box; other site 1279365004759 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1279365004760 G3 box; other site 1279365004761 Switch II region; other site 1279365004762 GTP/Mg2+ binding site [chemical binding]; other site 1279365004763 G4 box; other site 1279365004764 G5 box; other site 1279365004765 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 1279365004766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365004767 Coenzyme A binding pocket [chemical binding]; other site 1279365004768 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1279365004769 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1279365004770 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1279365004771 active site residue [active] 1279365004772 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1279365004773 active site residue [active] 1279365004774 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1279365004775 Predicted membrane protein [Function unknown]; Region: COG3766 1279365004776 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1279365004777 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1279365004778 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1279365004779 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365004780 5'-3' exonuclease; Region: 53EXOc; smart00475 1279365004781 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1279365004782 active site 1279365004783 metal binding site 1 [ion binding]; metal-binding site 1279365004784 putative 5' ssDNA interaction site; other site 1279365004785 metal binding site 3; metal-binding site 1279365004786 metal binding site 2 [ion binding]; metal-binding site 1279365004787 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1279365004788 putative DNA binding site [nucleotide binding]; other site 1279365004789 putative metal binding site [ion binding]; other site 1279365004790 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1279365004791 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1279365004792 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1279365004793 Chain length determinant protein; Region: Wzz; cl15801 1279365004794 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1279365004795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1279365004796 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1279365004797 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1279365004798 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1279365004799 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1279365004800 O-Antigen ligase; Region: Wzy_C; pfam04932 1279365004801 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365004802 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1279365004803 active site 1279365004804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1279365004805 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1279365004806 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1279365004807 Domain of unknown function DUF11; Region: DUF11; cl17728 1279365004808 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004809 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004810 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004811 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004812 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004813 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004814 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004815 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004816 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004817 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004818 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004819 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004820 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004821 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004822 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004823 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004824 Domain of unknown function DUF11; Region: DUF11; cl17728 1279365004825 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004826 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004827 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004828 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004829 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004830 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004831 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004832 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004833 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004834 Domain of unknown function DUF11; Region: DUF11; cl17728 1279365004835 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004836 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365004837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365004838 Coenzyme A binding pocket [chemical binding]; other site 1279365004839 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1279365004840 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365004841 catalytic triad [active] 1279365004842 conserved cis-peptide bond; other site 1279365004843 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365004844 EamA-like transporter family; Region: EamA; pfam00892 1279365004845 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1279365004846 RNA/DNA hybrid binding site [nucleotide binding]; other site 1279365004847 active site 1279365004848 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1279365004849 active site 1279365004850 catalytic residues [active] 1279365004851 QueT transporter; Region: QueT; pfam06177 1279365004852 hypothetical protein; Validated; Region: PRK07708 1279365004853 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1279365004854 RNA/DNA hybrid binding site [nucleotide binding]; other site 1279365004855 active site 1279365004856 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1279365004857 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1279365004858 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1279365004859 DNA-binding site [nucleotide binding]; DNA binding site 1279365004860 RNA-binding motif; other site 1279365004861 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1279365004862 LysE type translocator; Region: LysE; pfam01810 1279365004863 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1279365004864 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1279365004865 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1279365004866 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1279365004867 Na binding site [ion binding]; other site 1279365004868 aminotransferase; Validated; Region: PRK07678 1279365004869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365004870 inhibitor-cofactor binding pocket; inhibition site 1279365004871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365004872 catalytic residue [active] 1279365004873 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1279365004874 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1279365004875 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1279365004876 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365004877 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1279365004878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365004879 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1279365004880 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1279365004881 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1279365004882 DNA binding residues [nucleotide binding] 1279365004883 drug binding residues [chemical binding]; other site 1279365004884 dimer interface [polypeptide binding]; other site 1279365004885 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1279365004886 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1279365004887 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 1279365004888 Predicted membrane protein [Function unknown]; Region: COG2323 1279365004889 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1279365004890 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1279365004891 putative active site [active] 1279365004892 Tic20-like protein; Region: Tic20; pfam09685 1279365004893 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1279365004894 dimer interface [polypeptide binding]; other site 1279365004895 FMN binding site [chemical binding]; other site 1279365004896 NADPH bind site [chemical binding]; other site 1279365004897 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365004898 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365004899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365004900 putative substrate translocation pore; other site 1279365004901 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365004902 active site 1279365004903 metal binding site [ion binding]; metal-binding site 1279365004904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365004905 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1279365004906 bacterial Hfq-like; Region: Hfq; cd01716 1279365004907 hexamer interface [polypeptide binding]; other site 1279365004908 Sm1 motif; other site 1279365004909 RNA binding site [nucleotide binding]; other site 1279365004910 Sm2 motif; other site 1279365004911 HD domain; Region: HD_3; pfam13023 1279365004912 flagellar motor protein MotP; Reviewed; Region: PRK06743 1279365004913 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1279365004914 flagellar motor protein MotS; Reviewed; Region: PRK06742 1279365004915 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1279365004916 ligand binding site [chemical binding]; other site 1279365004917 Response regulator receiver domain; Region: Response_reg; pfam00072 1279365004918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365004919 active site 1279365004920 phosphorylation site [posttranslational modification] 1279365004921 intermolecular recognition site; other site 1279365004922 dimerization interface [polypeptide binding]; other site 1279365004923 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1279365004924 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1279365004925 putative binding surface; other site 1279365004926 active site 1279365004927 P2 response regulator binding domain; Region: P2; pfam07194 1279365004928 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1279365004929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365004930 ATP binding site [chemical binding]; other site 1279365004931 Mg2+ binding site [ion binding]; other site 1279365004932 G-X-G motif; other site 1279365004933 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1279365004934 flagellar motor switch protein; Reviewed; Region: PRK06782 1279365004935 CheC-like family; Region: CheC; pfam04509 1279365004936 CheC-like family; Region: CheC; pfam04509 1279365004937 CheC-like family; Region: CheC; pfam04509 1279365004938 CheC-like family; Region: CheC; pfam04509 1279365004939 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1279365004940 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1279365004941 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1279365004942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365004943 S-adenosylmethionine binding site [chemical binding]; other site 1279365004944 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1279365004945 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 1279365004946 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1279365004947 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 1279365004948 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1279365004949 flagellar capping protein; Validated; Region: fliD; PRK06798 1279365004950 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1279365004951 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1279365004952 Flagellar protein FliS; Region: FliS; cl00654 1279365004953 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 1279365004954 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1279365004955 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1279365004956 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1279365004957 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 1279365004958 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1279365004959 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1279365004960 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1279365004961 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1279365004962 FliG C-terminal domain; Region: FliG_C; pfam01706 1279365004963 flagellar assembly protein H; Validated; Region: fliH; PRK06800 1279365004964 Flagellar assembly protein FliH; Region: FliH; pfam02108 1279365004965 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 1279365004966 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365004967 Walker A motif; other site 1279365004968 ATP binding site [chemical binding]; other site 1279365004969 Walker B motif; other site 1279365004970 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1279365004971 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 1279365004972 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1279365004973 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1279365004974 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1279365004975 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1279365004976 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1279365004977 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 1279365004978 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1279365004979 Response regulator receiver domain; Region: Response_reg; pfam00072 1279365004980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365004981 active site 1279365004982 phosphorylation site [posttranslational modification] 1279365004983 intermolecular recognition site; other site 1279365004984 dimerization interface [polypeptide binding]; other site 1279365004985 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 1279365004986 flagellin; Provisional; Region: PRK12807 1279365004987 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1279365004988 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1279365004989 flagellin; Provisional; Region: PRK12807 1279365004990 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1279365004991 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1279365004992 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1279365004993 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1279365004994 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1279365004995 catalytic residue [active] 1279365004996 flagellar motor switch protein; Validated; Region: PRK06789 1279365004997 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1279365004998 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1279365004999 flagellar motor switch protein; Validated; Region: PRK06788 1279365005000 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1279365005001 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1279365005002 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1279365005003 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1279365005004 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1279365005005 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1279365005006 FHIPEP family; Region: FHIPEP; pfam00771 1279365005007 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 1279365005008 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1279365005009 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 1279365005010 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1279365005011 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1279365005012 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1279365005013 Predicted transcriptional regulators [Transcription]; Region: COG1378 1279365005014 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1279365005015 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1279365005016 C-terminal domain interface [polypeptide binding]; other site 1279365005017 sugar binding site [chemical binding]; other site 1279365005018 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1279365005019 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1279365005020 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 1279365005021 Dienelactone hydrolase family; Region: DLH; pfam01738 1279365005022 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 1279365005023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005024 non-specific DNA binding site [nucleotide binding]; other site 1279365005025 salt bridge; other site 1279365005026 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005028 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365005029 putative substrate translocation pore; other site 1279365005030 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1279365005031 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1279365005032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365005033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365005034 dimerization interface [polypeptide binding]; other site 1279365005035 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1279365005036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365005037 Walker A/P-loop; other site 1279365005038 ATP binding site [chemical binding]; other site 1279365005039 Q-loop/lid; other site 1279365005040 ABC transporter signature motif; other site 1279365005041 Walker B; other site 1279365005042 D-loop; other site 1279365005043 H-loop/switch region; other site 1279365005044 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1279365005045 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1279365005046 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1279365005047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365005048 dimer interface [polypeptide binding]; other site 1279365005049 conserved gate region; other site 1279365005050 putative PBP binding loops; other site 1279365005051 ABC-ATPase subunit interface; other site 1279365005052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365005053 dimer interface [polypeptide binding]; other site 1279365005054 conserved gate region; other site 1279365005055 putative PBP binding loops; other site 1279365005056 ABC-ATPase subunit interface; other site 1279365005057 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1279365005058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1279365005059 Beta-Casp domain; Region: Beta-Casp; smart01027 1279365005060 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1279365005061 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1279365005062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365005063 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365005064 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365005065 catalytic core [active] 1279365005066 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1279365005067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365005068 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365005069 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365005070 hypothetical protein; Provisional; Region: PRK09272 1279365005071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365005072 dimerization interface [polypeptide binding]; other site 1279365005073 putative Zn2+ binding site [ion binding]; other site 1279365005074 putative DNA binding site [nucleotide binding]; other site 1279365005075 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1279365005076 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1279365005077 active site 1279365005078 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1279365005079 dimer interface [polypeptide binding]; other site 1279365005080 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1279365005081 Ligand Binding Site [chemical binding]; other site 1279365005082 Molecular Tunnel; other site 1279365005083 RNA polymerase factor sigma-70; Validated; Region: PRK06811 1279365005084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365005085 DNA binding residues [nucleotide binding] 1279365005086 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1279365005087 VPS10 domain; Region: VPS10; smart00602 1279365005088 VPS10 domain; Region: VPS10; smart00602 1279365005089 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1279365005090 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1279365005091 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1279365005092 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1279365005093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365005094 DNA-binding site [nucleotide binding]; DNA binding site 1279365005095 FCD domain; Region: FCD; pfam07729 1279365005096 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365005097 EamA-like transporter family; Region: EamA; pfam00892 1279365005098 EamA-like transporter family; Region: EamA; pfam00892 1279365005099 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 1279365005100 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1279365005101 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1279365005102 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1279365005103 Predicted permeases [General function prediction only]; Region: COG0701 1279365005104 TIGR03943 family protein; Region: TIGR03943 1279365005105 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1279365005106 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1279365005107 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1279365005108 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1279365005109 DNA binding residues [nucleotide binding] 1279365005110 putative dimer interface [polypeptide binding]; other site 1279365005111 short chain dehydrogenase; Provisional; Region: PRK06123 1279365005112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365005113 NAD(P) binding site [chemical binding]; other site 1279365005114 active site 1279365005115 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1279365005116 Class II fumarases; Region: Fumarase_classII; cd01362 1279365005117 active site 1279365005118 tetramer interface [polypeptide binding]; other site 1279365005119 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1279365005120 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1279365005121 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1279365005122 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1279365005123 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1279365005124 active site pocket [active] 1279365005125 oxyanion hole [active] 1279365005126 catalytic triad [active] 1279365005127 active site nucleophile [active] 1279365005128 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 1279365005129 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1279365005130 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1279365005131 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1279365005132 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1279365005133 catalytic residues [active] 1279365005134 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1279365005135 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1279365005136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005137 non-specific DNA binding site [nucleotide binding]; other site 1279365005138 salt bridge; other site 1279365005139 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005140 Cupin domain; Region: Cupin_2; pfam07883 1279365005141 D-serine dehydratase; Provisional; Region: PRK02991 1279365005142 catalytic residue [active] 1279365005143 D-serine dehydratase; Provisional; Region: PRK02991 1279365005144 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1279365005145 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365005146 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1279365005147 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 1279365005148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365005149 DNA binding residues [nucleotide binding] 1279365005150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365005151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365005152 active site 1279365005153 phosphorylation site [posttranslational modification] 1279365005154 intermolecular recognition site; other site 1279365005155 dimerization interface [polypeptide binding]; other site 1279365005156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365005157 DNA binding residues [nucleotide binding] 1279365005158 dimerization interface [polypeptide binding]; other site 1279365005159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365005160 Histidine kinase; Region: HisKA_3; pfam07730 1279365005161 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365005162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365005163 Walker A/P-loop; other site 1279365005164 ATP binding site [chemical binding]; other site 1279365005165 Q-loop/lid; other site 1279365005166 ABC transporter signature motif; other site 1279365005167 Walker B; other site 1279365005168 D-loop; other site 1279365005169 H-loop/switch region; other site 1279365005170 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1279365005171 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1279365005172 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1279365005173 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1279365005174 PGAP1-like protein; Region: PGAP1; pfam07819 1279365005175 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1279365005176 PLD-like domain; Region: PLDc_2; pfam13091 1279365005177 putative active site [active] 1279365005178 catalytic site [active] 1279365005179 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1279365005180 PLD-like domain; Region: PLDc_2; pfam13091 1279365005181 putative active site [active] 1279365005182 catalytic site [active] 1279365005183 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1279365005184 putative nucleotide binding site [chemical binding]; other site 1279365005185 uridine monophosphate binding site [chemical binding]; other site 1279365005186 homohexameric interface [polypeptide binding]; other site 1279365005187 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365005188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365005189 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365005190 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1279365005191 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1279365005192 aspartate ammonia-lyase; Provisional; Region: PRK14515 1279365005193 Aspartase; Region: Aspartase; cd01357 1279365005194 active sites [active] 1279365005195 tetramer interface [polypeptide binding]; other site 1279365005196 malate dehydrogenase; Provisional; Region: PRK13529 1279365005197 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1279365005198 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1279365005199 NAD(P) binding site [chemical binding]; other site 1279365005200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365005201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365005202 ATP binding site [chemical binding]; other site 1279365005203 Mg2+ binding site [ion binding]; other site 1279365005204 G-X-G motif; other site 1279365005205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365005206 Response regulator receiver domain; Region: Response_reg; pfam00072 1279365005207 active site 1279365005208 phosphorylation site [posttranslational modification] 1279365005209 intermolecular recognition site; other site 1279365005210 dimerization interface [polypeptide binding]; other site 1279365005211 YcbB domain; Region: YcbB; pfam08664 1279365005212 SWIM zinc finger; Region: SWIM; pfam04434 1279365005213 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1279365005214 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1279365005215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365005216 ATP binding site [chemical binding]; other site 1279365005217 putative Mg++ binding site [ion binding]; other site 1279365005218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365005219 nucleotide binding region [chemical binding]; other site 1279365005220 ATP-binding site [chemical binding]; other site 1279365005221 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1279365005222 dimer interface [polypeptide binding]; other site 1279365005223 active site 1279365005224 putative transposase OrfB; Reviewed; Region: PHA02517 1279365005225 HTH-like domain; Region: HTH_21; pfam13276 1279365005226 Integrase core domain; Region: rve; pfam00665 1279365005227 Integrase core domain; Region: rve_2; pfam13333 1279365005228 Transposase; Region: HTH_Tnp_1; cl17663 1279365005229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365005230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005231 non-specific DNA binding site [nucleotide binding]; other site 1279365005232 salt bridge; other site 1279365005233 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005234 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365005235 aspartate kinase; Reviewed; Region: PRK06635 1279365005236 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1279365005237 putative nucleotide binding site [chemical binding]; other site 1279365005238 putative catalytic residues [active] 1279365005239 putative Mg ion binding site [ion binding]; other site 1279365005240 putative aspartate binding site [chemical binding]; other site 1279365005241 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1279365005242 putative allosteric regulatory site; other site 1279365005243 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1279365005244 putative allosteric regulatory residue; other site 1279365005245 Reovirus RNA-dependent RNA polymerase lambda 3; Region: RdRP_5; pfam07925 1279365005246 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1279365005247 YndJ-like protein; Region: YndJ; pfam14158 1279365005248 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1279365005249 putative active site [active] 1279365005250 nucleotide binding site [chemical binding]; other site 1279365005251 nudix motif; other site 1279365005252 putative metal binding site [ion binding]; other site 1279365005253 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365005254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005255 putative substrate translocation pore; other site 1279365005256 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1279365005257 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365005258 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365005259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365005261 putative substrate translocation pore; other site 1279365005262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005263 putative substrate translocation pore; other site 1279365005264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365005266 putative substrate translocation pore; other site 1279365005267 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1279365005268 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1279365005269 dimer interface [polypeptide binding]; other site 1279365005270 active site 1279365005271 CoA binding pocket [chemical binding]; other site 1279365005272 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1279365005273 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1279365005274 HflX GTPase family; Region: HflX; cd01878 1279365005275 G1 box; other site 1279365005276 GTP/Mg2+ binding site [chemical binding]; other site 1279365005277 Switch I region; other site 1279365005278 G2 box; other site 1279365005279 G3 box; other site 1279365005280 Switch II region; other site 1279365005281 G4 box; other site 1279365005282 G5 box; other site 1279365005283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365005285 putative substrate translocation pore; other site 1279365005286 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1279365005287 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1279365005288 dimer interface [polypeptide binding]; other site 1279365005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365005290 catalytic residue [active] 1279365005291 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1279365005292 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1279365005293 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1279365005294 Na2 binding site [ion binding]; other site 1279365005295 putative substrate binding site 1 [chemical binding]; other site 1279365005296 Na binding site 1 [ion binding]; other site 1279365005297 putative substrate binding site 2 [chemical binding]; other site 1279365005298 Mor transcription activator family; Region: Mor; cl02360 1279365005299 Predicted membrane protein [Function unknown]; Region: COG2323 1279365005300 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1279365005301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1279365005302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1279365005303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1279365005304 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1279365005305 short chain dehydrogenase; Provisional; Region: PRK12747 1279365005306 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1279365005307 NADP binding site [chemical binding]; other site 1279365005308 homodimer interface [polypeptide binding]; other site 1279365005309 active site 1279365005310 substrate binding site [chemical binding]; other site 1279365005311 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1279365005312 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1279365005313 homodimer interface [polypeptide binding]; other site 1279365005314 substrate-cofactor binding pocket; other site 1279365005315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365005316 catalytic residue [active] 1279365005317 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 1279365005318 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1279365005319 PYR/PP interface [polypeptide binding]; other site 1279365005320 dimer interface [polypeptide binding]; other site 1279365005321 TPP binding site [chemical binding]; other site 1279365005322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1279365005323 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1279365005324 TPP-binding site [chemical binding]; other site 1279365005325 dimer interface [polypeptide binding]; other site 1279365005326 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1279365005327 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1279365005328 putative valine binding site [chemical binding]; other site 1279365005329 dimer interface [polypeptide binding]; other site 1279365005330 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1279365005331 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1279365005332 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1279365005333 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1279365005334 threonine dehydratase; Validated; Region: PRK08639 1279365005335 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1279365005336 tetramer interface [polypeptide binding]; other site 1279365005337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365005338 catalytic residue [active] 1279365005339 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1279365005340 putative Ile/Val binding site [chemical binding]; other site 1279365005341 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1279365005342 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1279365005343 putative active site [active] 1279365005344 putative metal binding site [ion binding]; other site 1279365005345 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1279365005346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1279365005347 drug efflux system protein MdtG; Provisional; Region: PRK09874 1279365005348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005349 putative substrate translocation pore; other site 1279365005350 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1279365005351 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1279365005352 putative active site [active] 1279365005353 metal binding site [ion binding]; metal-binding site 1279365005354 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1279365005355 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365005356 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1279365005357 LytTr DNA-binding domain; Region: LytTR; pfam04397 1279365005358 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1279365005359 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1279365005360 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1279365005361 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1279365005362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365005363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365005364 Coenzyme A binding pocket [chemical binding]; other site 1279365005365 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 1279365005366 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1279365005367 active site 1279365005368 putative substrate binding pocket [chemical binding]; other site 1279365005369 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365005370 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365005371 peptide binding site [polypeptide binding]; other site 1279365005372 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365005373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365005374 Coenzyme A binding pocket [chemical binding]; other site 1279365005375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365005376 manganese transport protein MntH; Reviewed; Region: PRK00701 1279365005377 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1279365005378 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1279365005379 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1279365005380 active site residue [active] 1279365005381 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1279365005382 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1279365005383 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1279365005384 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1279365005385 Amino acid permease; Region: AA_permease_2; pfam13520 1279365005386 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365005387 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365005388 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365005389 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1279365005390 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1279365005391 CAAX protease self-immunity; Region: Abi; pfam02517 1279365005392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365005393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365005394 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1279365005395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365005396 DNA binding residues [nucleotide binding] 1279365005397 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1279365005398 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1279365005399 intersubunit interface [polypeptide binding]; other site 1279365005400 active site 1279365005401 catalytic residue [active] 1279365005402 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365005403 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365005404 Nucleoside recognition; Region: Gate; pfam07670 1279365005405 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365005406 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1279365005407 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1279365005408 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1279365005409 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1279365005410 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1279365005411 active site 1279365005412 catalytic motif [active] 1279365005413 Zn binding site [ion binding]; other site 1279365005414 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1279365005415 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1279365005416 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1279365005417 proline aminopeptidase P II; Provisional; Region: PRK10879 1279365005418 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1279365005419 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1279365005420 active site 1279365005421 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1279365005422 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1279365005423 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1279365005424 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1279365005425 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 1279365005426 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1279365005427 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1279365005428 DNA topoisomerase III; Provisional; Region: PRK07726 1279365005429 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1279365005430 active site 1279365005431 putative interdomain interaction site [polypeptide binding]; other site 1279365005432 putative metal-binding site [ion binding]; other site 1279365005433 putative nucleotide binding site [chemical binding]; other site 1279365005434 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1279365005435 domain I; other site 1279365005436 DNA binding groove [nucleotide binding] 1279365005437 phosphate binding site [ion binding]; other site 1279365005438 domain II; other site 1279365005439 domain III; other site 1279365005440 nucleotide binding site [chemical binding]; other site 1279365005441 catalytic site [active] 1279365005442 domain IV; other site 1279365005443 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1279365005444 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1279365005445 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1279365005446 Sodium Bile acid symporter family; Region: SBF; cl17470 1279365005447 azoreductase; Provisional; Region: PRK13555 1279365005448 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1279365005449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365005450 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1279365005451 dimer interface [polypeptide binding]; other site 1279365005452 substrate binding site [chemical binding]; other site 1279365005453 metal binding site [ion binding]; metal-binding site 1279365005454 CopC domain; Region: CopC; pfam04234 1279365005455 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1279365005456 YtkA-like; Region: YtkA; pfam13115 1279365005457 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1279365005458 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365005459 EamA-like transporter family; Region: EamA; pfam00892 1279365005460 EamA-like transporter family; Region: EamA; pfam00892 1279365005461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365005462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365005463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365005464 dimerization interface [polypeptide binding]; other site 1279365005465 Predicted transcriptional regulator [Transcription]; Region: COG1959 1279365005466 Transcriptional regulator; Region: Rrf2; pfam02082 1279365005467 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1279365005468 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1279365005469 catalytic residues [active] 1279365005470 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1279365005471 dimer interface [polypeptide binding]; other site 1279365005472 FMN binding site [chemical binding]; other site 1279365005473 amidase; Provisional; Region: PRK06707 1279365005474 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1279365005475 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1279365005476 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1279365005477 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365005478 NAD binding site [chemical binding]; other site 1279365005479 dimer interface [polypeptide binding]; other site 1279365005480 substrate binding site [chemical binding]; other site 1279365005481 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1279365005482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365005483 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1279365005484 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1279365005485 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1279365005486 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1279365005487 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 1279365005488 putative ligand binding site [chemical binding]; other site 1279365005489 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1279365005490 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1279365005491 Walker A/P-loop; other site 1279365005492 ATP binding site [chemical binding]; other site 1279365005493 Q-loop/lid; other site 1279365005494 ABC transporter signature motif; other site 1279365005495 Walker B; other site 1279365005496 D-loop; other site 1279365005497 H-loop/switch region; other site 1279365005498 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1279365005499 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1279365005500 Walker A/P-loop; other site 1279365005501 ATP binding site [chemical binding]; other site 1279365005502 Q-loop/lid; other site 1279365005503 ABC transporter signature motif; other site 1279365005504 Walker B; other site 1279365005505 D-loop; other site 1279365005506 H-loop/switch region; other site 1279365005507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1279365005508 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1279365005509 TM-ABC transporter signature motif; other site 1279365005510 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1279365005511 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1279365005512 TM-ABC transporter signature motif; other site 1279365005513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365005514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365005515 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1279365005516 dimerization interface [polypeptide binding]; other site 1279365005517 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1279365005518 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1279365005519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365005520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365005521 putative DNA binding site [nucleotide binding]; other site 1279365005522 putative Zn2+ binding site [ion binding]; other site 1279365005523 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1279365005524 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1279365005525 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1279365005526 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1279365005527 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1279365005528 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1279365005529 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1279365005530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365005531 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1279365005532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365005533 Walker A/P-loop; other site 1279365005534 ATP binding site [chemical binding]; other site 1279365005535 Q-loop/lid; other site 1279365005536 ABC transporter signature motif; other site 1279365005537 Walker B; other site 1279365005538 D-loop; other site 1279365005539 H-loop/switch region; other site 1279365005540 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1279365005541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365005542 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1279365005543 Walker A/P-loop; other site 1279365005544 ATP binding site [chemical binding]; other site 1279365005545 Q-loop/lid; other site 1279365005546 ABC transporter signature motif; other site 1279365005547 Walker B; other site 1279365005548 D-loop; other site 1279365005549 H-loop/switch region; other site 1279365005550 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1279365005551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1279365005552 active site 1279365005553 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1279365005554 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365005555 active site 1279365005556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365005557 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365005558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1279365005559 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1279365005560 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1279365005561 inhibitor-cofactor binding pocket; inhibition site 1279365005562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365005563 catalytic residue [active] 1279365005564 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1279365005565 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1279365005566 trimer interface [polypeptide binding]; other site 1279365005567 active site 1279365005568 substrate binding site [chemical binding]; other site 1279365005569 CoA binding site [chemical binding]; other site 1279365005570 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1279365005571 putative dimer interface [polypeptide binding]; other site 1279365005572 catalytic triad [active] 1279365005573 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365005574 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1279365005575 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1279365005576 dimer interface [polypeptide binding]; other site 1279365005577 FMN binding site [chemical binding]; other site 1279365005578 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365005579 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365005580 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365005581 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1279365005582 NlpC/P60 family; Region: NLPC_P60; pfam00877 1279365005583 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365005584 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365005585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365005586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365005587 Walker A/P-loop; other site 1279365005588 ATP binding site [chemical binding]; other site 1279365005589 Q-loop/lid; other site 1279365005590 ABC transporter signature motif; other site 1279365005591 Walker B; other site 1279365005592 D-loop; other site 1279365005593 H-loop/switch region; other site 1279365005594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365005595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365005596 active site 1279365005597 phosphorylation site [posttranslational modification] 1279365005598 intermolecular recognition site; other site 1279365005599 dimerization interface [polypeptide binding]; other site 1279365005600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365005601 DNA binding site [nucleotide binding] 1279365005602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365005603 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365005604 dimerization interface [polypeptide binding]; other site 1279365005605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365005606 dimer interface [polypeptide binding]; other site 1279365005607 phosphorylation site [posttranslational modification] 1279365005608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365005609 ATP binding site [chemical binding]; other site 1279365005610 Mg2+ binding site [ion binding]; other site 1279365005611 G-X-G motif; other site 1279365005612 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1279365005613 classical (c) SDRs; Region: SDR_c; cd05233 1279365005614 NAD(P) binding site [chemical binding]; other site 1279365005615 active site 1279365005616 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1279365005617 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365005618 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1279365005619 NodB motif; other site 1279365005620 active site 1279365005621 catalytic site [active] 1279365005622 metal binding site [ion binding]; metal-binding site 1279365005623 SdpI/YhfL protein family; Region: SdpI; pfam13630 1279365005624 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 1279365005625 nudix motif; other site 1279365005626 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1279365005627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365005628 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365005629 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365005630 homoserine dehydrogenase; Provisional; Region: PRK06349 1279365005631 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1279365005632 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1279365005633 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1279365005634 threonine synthase; Reviewed; Region: PRK06721 1279365005635 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1279365005636 homodimer interface [polypeptide binding]; other site 1279365005637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365005638 catalytic residue [active] 1279365005639 homoserine kinase; Provisional; Region: PRK01212 1279365005640 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1279365005641 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1279365005642 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1279365005643 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1279365005644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365005645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365005646 active site 1279365005647 phosphorylation site [posttranslational modification] 1279365005648 intermolecular recognition site; other site 1279365005649 dimerization interface [polypeptide binding]; other site 1279365005650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365005651 DNA binding site [nucleotide binding] 1279365005652 HAMP domain; Region: HAMP; pfam00672 1279365005653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365005654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365005655 dimer interface [polypeptide binding]; other site 1279365005656 phosphorylation site [posttranslational modification] 1279365005657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365005658 ATP binding site [chemical binding]; other site 1279365005659 Mg2+ binding site [ion binding]; other site 1279365005660 G-X-G motif; other site 1279365005661 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365005662 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1279365005663 NodB motif; other site 1279365005664 active site 1279365005665 catalytic site [active] 1279365005666 Zn binding site [ion binding]; other site 1279365005667 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1279365005668 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1279365005669 MgtC family; Region: MgtC; pfam02308 1279365005670 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1279365005671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365005672 Coenzyme A binding pocket [chemical binding]; other site 1279365005673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1279365005674 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1279365005675 Probable transposase; Region: OrfB_IS605; pfam01385 1279365005676 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1279365005677 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1279365005678 IucA / IucC family; Region: IucA_IucC; pfam04183 1279365005679 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1279365005680 IucA / IucC family; Region: IucA_IucC; pfam04183 1279365005681 transposase/IS protein; Provisional; Region: PRK09183 1279365005682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365005683 Walker A motif; other site 1279365005684 ATP binding site [chemical binding]; other site 1279365005685 Walker B motif; other site 1279365005686 arginine finger; other site 1279365005687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365005688 Integrase core domain; Region: rve; pfam00665 1279365005689 IucA / IucC family; Region: IucA_IucC; pfam04183 1279365005690 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1279365005691 acyl-CoA synthetase; Validated; Region: PRK08308 1279365005692 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1279365005693 acyl-activating enzyme (AAE) consensus motif; other site 1279365005694 AMP binding site [chemical binding]; other site 1279365005695 active site 1279365005696 CoA binding site [chemical binding]; other site 1279365005697 acyl carrier protein; Provisional; Region: PRK07639 1279365005698 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1279365005699 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1279365005700 Metal-binding active site; metal-binding site 1279365005701 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1279365005702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365005704 putative substrate translocation pore; other site 1279365005705 Lysine efflux permease [General function prediction only]; Region: COG1279 1279365005706 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365005707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365005708 DNA-binding site [nucleotide binding]; DNA binding site 1279365005709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365005710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365005711 homodimer interface [polypeptide binding]; other site 1279365005712 catalytic residue [active] 1279365005713 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 1279365005714 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1279365005715 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1279365005716 active site 1279365005717 nucleophile elbow; other site 1279365005718 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1279365005719 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1279365005720 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 1279365005721 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1279365005722 nudix motif; other site 1279365005723 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1279365005724 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1279365005725 homodimer interface [polypeptide binding]; other site 1279365005726 NAD binding pocket [chemical binding]; other site 1279365005727 ATP binding pocket [chemical binding]; other site 1279365005728 Mg binding site [ion binding]; other site 1279365005729 active-site loop [active] 1279365005730 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1279365005731 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1279365005732 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1279365005733 active site 1279365005734 catalytic residues [active] 1279365005735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365005736 dimerization interface [polypeptide binding]; other site 1279365005737 putative DNA binding site [nucleotide binding]; other site 1279365005738 putative Zn2+ binding site [ion binding]; other site 1279365005739 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365005740 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365005741 active site 1279365005742 catalytic tetrad [active] 1279365005743 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1279365005744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005745 putative substrate translocation pore; other site 1279365005746 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1279365005747 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1279365005748 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1279365005749 GTPase RsgA; Reviewed; Region: PRK01889 1279365005750 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1279365005751 RNA binding site [nucleotide binding]; other site 1279365005752 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1279365005753 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1279365005754 GTP/Mg2+ binding site [chemical binding]; other site 1279365005755 G4 box; other site 1279365005756 G5 box; other site 1279365005757 G1 box; other site 1279365005758 Switch I region; other site 1279365005759 G2 box; other site 1279365005760 G3 box; other site 1279365005761 Switch II region; other site 1279365005762 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1279365005763 Cache domain; Region: Cache_1; pfam02743 1279365005764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365005765 dimerization interface [polypeptide binding]; other site 1279365005766 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365005767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365005768 dimer interface [polypeptide binding]; other site 1279365005769 putative CheW interface [polypeptide binding]; other site 1279365005770 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 1279365005771 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1279365005772 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1279365005773 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1279365005774 dimerization interface [polypeptide binding]; other site 1279365005775 DPS ferroxidase diiron center [ion binding]; other site 1279365005776 ion pore; other site 1279365005777 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 1279365005778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1279365005779 putative transposase OrfB; Reviewed; Region: PHA02517 1279365005780 HTH-like domain; Region: HTH_21; pfam13276 1279365005781 Integrase core domain; Region: rve; pfam00665 1279365005782 Integrase core domain; Region: rve_2; pfam13333 1279365005783 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1279365005784 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1279365005785 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 1279365005786 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1279365005787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365005788 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365005789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365005790 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365005791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365005792 active site 1279365005793 catalytic tetrad [active] 1279365005794 Probable transposase; Region: OrfB_IS605; pfam01385 1279365005795 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1279365005796 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1279365005797 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1279365005798 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1279365005799 P-loop, Walker A motif; other site 1279365005800 Base recognition motif; other site 1279365005801 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1279365005802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365005803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365005804 Coenzyme A binding pocket [chemical binding]; other site 1279365005805 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1279365005806 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1279365005807 metal binding site [ion binding]; metal-binding site 1279365005808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365005809 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365005810 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365005811 putative active site [active] 1279365005812 putative NTP binding site [chemical binding]; other site 1279365005813 putative nucleic acid binding site [nucleotide binding]; other site 1279365005814 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365005815 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1279365005816 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1279365005817 NAD binding site [chemical binding]; other site 1279365005818 active site 1279365005819 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1279365005820 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1279365005821 active site 1279365005822 FMN binding site [chemical binding]; other site 1279365005823 substrate binding site [chemical binding]; other site 1279365005824 homotetramer interface [polypeptide binding]; other site 1279365005825 catalytic residue [active] 1279365005826 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1279365005827 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1279365005828 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1279365005829 DNA binding site [nucleotide binding] 1279365005830 active site 1279365005831 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1279365005832 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365005833 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365005834 peptide binding site [polypeptide binding]; other site 1279365005835 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1279365005836 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365005837 active site 1279365005838 metal binding site [ion binding]; metal-binding site 1279365005839 short chain dehydrogenase; Provisional; Region: PRK08309 1279365005840 short chain dehydrogenase; Provisional; Region: PRK08309 1279365005841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365005842 catalytic core [active] 1279365005843 CotH protein; Region: CotH; pfam08757 1279365005844 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1279365005845 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1279365005846 nudix motif; other site 1279365005847 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365005848 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365005849 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1279365005850 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1279365005851 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1279365005852 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1279365005853 Cl binding site [ion binding]; other site 1279365005854 oligomer interface [polypeptide binding]; other site 1279365005855 Predicted permeases [General function prediction only]; Region: COG0701 1279365005856 Predicted membrane protein [Function unknown]; Region: COG3689 1279365005857 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1279365005858 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1279365005859 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1279365005860 putative active site [active] 1279365005861 catalytic site [active] 1279365005862 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1279365005863 putative active site [active] 1279365005864 catalytic site [active] 1279365005865 Coat F domain; Region: Coat_F; pfam07875 1279365005866 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1279365005867 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1279365005868 NAD binding site [chemical binding]; other site 1279365005869 substrate binding site [chemical binding]; other site 1279365005870 putative active site [active] 1279365005871 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1279365005872 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1279365005873 Domain of unknown function DUF21; Region: DUF21; pfam01595 1279365005874 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1279365005875 Transporter associated domain; Region: CorC_HlyC; smart01091 1279365005876 FOG: CBS domain [General function prediction only]; Region: COG0517 1279365005877 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1279365005878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365005879 HTH-like domain; Region: HTH_21; pfam13276 1279365005880 Integrase core domain; Region: rve; pfam00665 1279365005881 Integrase core domain; Region: rve_2; pfam13333 1279365005882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365005883 Transposase; Region: HTH_Tnp_1; cl17663 1279365005884 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365005885 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1279365005886 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1279365005887 dimer interface [polypeptide binding]; other site 1279365005888 putative tRNA-binding site [nucleotide binding]; other site 1279365005889 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1279365005890 DinB superfamily; Region: DinB_2; pfam12867 1279365005891 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1279365005892 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1279365005893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365005894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365005895 Coenzyme A binding pocket [chemical binding]; other site 1279365005896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365005897 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1279365005898 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1279365005899 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1279365005900 nudix motif; other site 1279365005901 amidase; Provisional; Region: PRK06828 1279365005902 Amidase; Region: Amidase; pfam01425 1279365005903 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365005904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365005905 putative substrate translocation pore; other site 1279365005906 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1279365005907 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1279365005908 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1279365005909 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1279365005910 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1279365005911 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365005912 catalytic core [active] 1279365005913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365005914 active site 1279365005915 motif I; other site 1279365005916 motif II; other site 1279365005917 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1279365005918 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1279365005919 Int/Topo IB signature motif; other site 1279365005920 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365005921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005922 non-specific DNA binding site [nucleotide binding]; other site 1279365005923 salt bridge; other site 1279365005924 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005926 non-specific DNA binding site [nucleotide binding]; other site 1279365005927 salt bridge; other site 1279365005928 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005930 non-specific DNA binding site [nucleotide binding]; other site 1279365005931 salt bridge; other site 1279365005932 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005933 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1279365005934 ORF6C domain; Region: ORF6C; pfam10552 1279365005935 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1279365005936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365005937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365005938 DNA binding residues [nucleotide binding] 1279365005939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1279365005940 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1279365005941 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1279365005942 YjcQ protein; Region: YjcQ; pfam09639 1279365005943 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1279365005944 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1279365005945 Int/Topo IB signature motif; other site 1279365005946 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1279365005947 HNH endonuclease; Region: HNH; pfam01844 1279365005948 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1279365005949 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365005950 Phage portal protein; Region: Phage_portal; pfam04860 1279365005951 Phage-related protein [Function unknown]; Region: COG4695 1279365005952 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1279365005953 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1279365005954 oligomer interface [polypeptide binding]; other site 1279365005955 active site residues [active] 1279365005956 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365005957 Phage capsid family; Region: Phage_capsid; pfam05065 1279365005958 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1279365005959 oligomerization interface [polypeptide binding]; other site 1279365005960 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1279365005961 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1279365005962 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1279365005963 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365005964 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365005965 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365005966 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365005967 putative active site [active] 1279365005968 putative NTP binding site [chemical binding]; other site 1279365005969 putative nucleic acid binding site [nucleotide binding]; other site 1279365005970 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365005971 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1279365005972 MAEBL; Provisional; Region: PTZ00121 1279365005973 Phage-related protein [Function unknown]; Region: COG5412 1279365005974 Phage tail protein; Region: Sipho_tail; pfam05709 1279365005975 Phage tail protein; Region: Sipho_tail; cl17486 1279365005976 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365005977 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 1279365005978 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1279365005979 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1279365005980 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365005981 active site 1279365005982 catalytic residues [active] 1279365005983 DNA binding site [nucleotide binding] 1279365005984 Int/Topo IB signature motif; other site 1279365005985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365005986 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365005987 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365005988 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1279365005989 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365005990 amidase catalytic site [active] 1279365005991 Zn binding residues [ion binding]; other site 1279365005992 substrate binding site [chemical binding]; other site 1279365005993 Bacterial SH3 domain; Region: SH3_3; cl17532 1279365005994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365005995 non-specific DNA binding site [nucleotide binding]; other site 1279365005996 salt bridge; other site 1279365005997 sequence-specific DNA binding site [nucleotide binding]; other site 1279365005998 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365005999 Replication-relaxation; Region: Replic_Relax; pfam13814 1279365006000 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365006001 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365006002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365006003 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1279365006004 DinB superfamily; Region: DinB_2; pfam12867 1279365006005 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1279365006006 alanine racemase; Reviewed; Region: alr; PRK00053 1279365006007 active site 1279365006008 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1279365006009 dimer interface [polypeptide binding]; other site 1279365006010 substrate binding site [chemical binding]; other site 1279365006011 catalytic residues [active] 1279365006012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006013 Coenzyme A binding pocket [chemical binding]; other site 1279365006014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006015 Coenzyme A binding pocket [chemical binding]; other site 1279365006016 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1279365006017 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1279365006018 active site 1279365006019 TDP-binding site; other site 1279365006020 acceptor substrate-binding pocket; other site 1279365006021 homodimer interface [polypeptide binding]; other site 1279365006022 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365006023 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365006024 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365006025 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365006026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365006027 DNA-binding site [nucleotide binding]; DNA binding site 1279365006028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365006029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365006030 homodimer interface [polypeptide binding]; other site 1279365006031 catalytic residue [active] 1279365006032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006033 Coenzyme A binding pocket [chemical binding]; other site 1279365006034 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365006035 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1279365006036 active site 1279365006037 metal binding site [ion binding]; metal-binding site 1279365006038 Src Homology 3 domain superfamily; Region: SH3; cl17036 1279365006039 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1279365006040 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365006041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006042 Coenzyme A binding pocket [chemical binding]; other site 1279365006043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365006044 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1279365006045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365006046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006047 Coenzyme A binding pocket [chemical binding]; other site 1279365006048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006049 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365006050 Coenzyme A binding pocket [chemical binding]; other site 1279365006051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1279365006052 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1279365006053 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1279365006054 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1279365006055 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1279365006056 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1279365006057 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1279365006058 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1279365006059 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1279365006060 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365006061 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365006062 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1279365006063 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1279365006064 nucleophilic elbow; other site 1279365006065 catalytic triad; other site 1279365006066 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1279365006067 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1279365006068 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1279365006069 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 1279365006070 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1279365006071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006072 Coenzyme A binding pocket [chemical binding]; other site 1279365006073 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1279365006074 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365006075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365006076 S-adenosylmethionine binding site [chemical binding]; other site 1279365006077 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1279365006078 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1279365006079 Potassium binding sites [ion binding]; other site 1279365006080 Cesium cation binding sites [ion binding]; other site 1279365006081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1279365006082 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1279365006083 ATP binding site [chemical binding]; other site 1279365006084 putative Mg++ binding site [ion binding]; other site 1279365006085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365006086 nucleotide binding region [chemical binding]; other site 1279365006087 ATP-binding site [chemical binding]; other site 1279365006088 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1279365006089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365006090 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1279365006091 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365006092 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1279365006093 NADP binding site [chemical binding]; other site 1279365006094 dimer interface [polypeptide binding]; other site 1279365006095 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365006096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365006097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365006098 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365006099 RNA polymerase sigma factor; Provisional; Region: PRK12543 1279365006100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365006101 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365006102 DNA binding residues [nucleotide binding] 1279365006103 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 1279365006104 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365006105 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365006106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365006107 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365006108 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 1279365006109 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1279365006110 catalytic residues [active] 1279365006111 dimer interface [polypeptide binding]; other site 1279365006112 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1279365006113 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1279365006114 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1279365006115 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1279365006116 Protein of unknown function DUF58; Region: DUF58; pfam01882 1279365006117 MoxR-like ATPases [General function prediction only]; Region: COG0714 1279365006118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365006119 Walker A motif; other site 1279365006120 ATP binding site [chemical binding]; other site 1279365006121 Walker B motif; other site 1279365006122 arginine finger; other site 1279365006123 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365006124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365006125 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365006126 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1279365006127 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1279365006128 [4Fe-4S] binding site [ion binding]; other site 1279365006129 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1279365006130 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1279365006131 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1279365006132 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1279365006133 molybdopterin cofactor binding site; other site 1279365006134 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1279365006135 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1279365006136 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1279365006137 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1279365006138 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365006139 ligand binding site [chemical binding]; other site 1279365006140 flexible hinge region; other site 1279365006141 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1279365006142 putative switch regulator; other site 1279365006143 non-specific DNA interactions [nucleotide binding]; other site 1279365006144 DNA binding site [nucleotide binding] 1279365006145 sequence specific DNA binding site [nucleotide binding]; other site 1279365006146 putative cAMP binding site [chemical binding]; other site 1279365006147 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1279365006148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365006149 FeS/SAM binding site; other site 1279365006150 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1279365006151 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1279365006152 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1279365006153 ATP binding site [chemical binding]; other site 1279365006154 substrate interface [chemical binding]; other site 1279365006155 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1279365006156 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1279365006157 dimer interface [polypeptide binding]; other site 1279365006158 putative functional site; other site 1279365006159 putative MPT binding site; other site 1279365006160 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1279365006161 MoaE homodimer interface [polypeptide binding]; other site 1279365006162 MoaD interaction [polypeptide binding]; other site 1279365006163 active site residues [active] 1279365006164 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1279365006165 MoaE interaction surface [polypeptide binding]; other site 1279365006166 MoeB interaction surface [polypeptide binding]; other site 1279365006167 thiocarboxylated glycine; other site 1279365006168 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1279365006169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006170 putative substrate translocation pore; other site 1279365006171 precorrin-2 dehydrogenase; Validated; Region: PRK06719 1279365006172 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1279365006173 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1279365006174 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1279365006175 putative active site [active] 1279365006176 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1279365006177 putative active site [active] 1279365006178 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1279365006179 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1279365006180 active site 1279365006181 SAM binding site [chemical binding]; other site 1279365006182 homodimer interface [polypeptide binding]; other site 1279365006183 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1279365006184 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1279365006185 [2Fe-2S] cluster binding site [ion binding]; other site 1279365006186 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1279365006187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365006188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365006189 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1279365006190 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1279365006191 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1279365006192 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1279365006193 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1279365006194 Hemerythrin-like domain; Region: Hr-like; cd12108 1279365006195 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1279365006196 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1279365006197 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1279365006198 PGAP1-like protein; Region: PGAP1; pfam07819 1279365006199 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1279365006200 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1279365006201 active site 1279365006202 YolD-like protein; Region: YolD; pfam08863 1279365006203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365006204 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1279365006205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365006206 active site 1279365006207 DNA binding site [nucleotide binding] 1279365006208 Int/Topo IB signature motif; other site 1279365006209 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1279365006210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365006211 active site 1279365006212 DNA binding site [nucleotide binding] 1279365006213 Int/Topo IB signature motif; other site 1279365006214 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365006215 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1279365006216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365006217 Zn2+ binding site [ion binding]; other site 1279365006218 Mg2+ binding site [ion binding]; other site 1279365006219 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365006220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365006221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365006222 ABC transporter; Region: ABC_tran_2; pfam12848 1279365006223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365006224 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1279365006225 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 1279365006226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365006227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365006228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365006229 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365006230 transposase/IS protein; Provisional; Region: PRK09183 1279365006231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365006232 Walker A motif; other site 1279365006233 ATP binding site [chemical binding]; other site 1279365006234 Walker B motif; other site 1279365006235 arginine finger; other site 1279365006236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365006237 Integrase core domain; Region: rve; pfam00665 1279365006238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365006239 DNA binding site [nucleotide binding] 1279365006240 active site 1279365006241 Int/Topo IB signature motif; other site 1279365006242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365006243 active site 1279365006244 DNA binding site [nucleotide binding] 1279365006245 Int/Topo IB signature motif; other site 1279365006246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365006247 ATP binding site [chemical binding]; other site 1279365006248 Mg2+ binding site [ion binding]; other site 1279365006249 G-X-G motif; other site 1279365006250 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1279365006251 AAA ATPase domain; Region: AAA_16; pfam13191 1279365006252 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1279365006253 Walker A motif; other site 1279365006254 ATP binding site [chemical binding]; other site 1279365006255 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365006256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365006257 non-specific DNA binding site [nucleotide binding]; other site 1279365006258 salt bridge; other site 1279365006259 sequence-specific DNA binding site [nucleotide binding]; other site 1279365006260 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1279365006261 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1279365006262 dimer interface [polypeptide binding]; other site 1279365006263 ssDNA binding site [nucleotide binding]; other site 1279365006264 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365006265 AAA domain; Region: AAA_18; pfam13238 1279365006266 AAA domain; Region: AAA_17; pfam13207 1279365006267 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1279365006268 Virulence factor; Region: Virulence_fact; pfam13769 1279365006269 HEAT repeats; Region: HEAT_2; pfam13646 1279365006270 HEAT repeats; Region: HEAT_2; pfam13646 1279365006271 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1279365006272 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1279365006273 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1279365006274 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1279365006275 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1279365006276 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1279365006277 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1279365006278 active site 1279365006279 HIGH motif; other site 1279365006280 KMSK motif region; other site 1279365006281 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1279365006282 tRNA binding surface [nucleotide binding]; other site 1279365006283 anticodon binding site; other site 1279365006284 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 1279365006285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006286 binding surface 1279365006287 TPR motif; other site 1279365006288 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1279365006289 putative active site [active] 1279365006290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006291 binding surface 1279365006292 TPR motif; other site 1279365006293 TPR repeat; Region: TPR_11; pfam13414 1279365006294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006295 binding surface 1279365006296 TPR motif; other site 1279365006297 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365006298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006299 binding surface 1279365006300 TPR motif; other site 1279365006301 TPR repeat; Region: TPR_11; pfam13414 1279365006302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006303 binding surface 1279365006304 TPR motif; other site 1279365006305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006306 binding surface 1279365006307 TPR motif; other site 1279365006308 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365006309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365006310 binding surface 1279365006311 TPR motif; other site 1279365006312 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1279365006313 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1279365006314 HIGH motif; other site 1279365006315 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1279365006316 active site 1279365006317 KMSKS motif; other site 1279365006318 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1279365006319 tRNA binding surface [nucleotide binding]; other site 1279365006320 anticodon binding site; other site 1279365006321 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1279365006322 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1279365006323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365006324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365006325 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365006326 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365006327 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1279365006328 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1279365006329 Zn binding site [ion binding]; other site 1279365006330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365006331 HTH-like domain; Region: HTH_21; pfam13276 1279365006332 Integrase core domain; Region: rve; pfam00665 1279365006333 Integrase core domain; Region: rve_2; pfam13333 1279365006334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365006335 Transposase; Region: HTH_Tnp_1; cl17663 1279365006336 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365006337 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1279365006338 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1279365006339 Dimer interface [polypeptide binding]; other site 1279365006340 anticodon binding site; other site 1279365006341 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1279365006342 homodimer interface [polypeptide binding]; other site 1279365006343 motif 1; other site 1279365006344 motif 2; other site 1279365006345 active site 1279365006346 motif 3; other site 1279365006347 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1279365006348 Na2 binding site [ion binding]; other site 1279365006349 putative substrate binding site 1 [chemical binding]; other site 1279365006350 Na binding site 1 [ion binding]; other site 1279365006351 putative substrate binding site 2 [chemical binding]; other site 1279365006352 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365006353 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1279365006354 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1279365006355 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1279365006356 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1279365006357 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1279365006358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365006359 motif II; other site 1279365006360 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1279365006361 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1279365006362 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1279365006363 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1279365006364 putative active site [active] 1279365006365 metal binding site [ion binding]; metal-binding site 1279365006366 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1279365006367 aspartate racemase; Region: asp_race; TIGR00035 1279365006368 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1279365006369 homodimer interaction site [polypeptide binding]; other site 1279365006370 cofactor binding site; other site 1279365006371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365006372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006373 Coenzyme A binding pocket [chemical binding]; other site 1279365006374 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1279365006375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365006376 salt bridge; other site 1279365006377 non-specific DNA binding site [nucleotide binding]; other site 1279365006378 sequence-specific DNA binding site [nucleotide binding]; other site 1279365006379 hypothetical protein; Validated; Region: PRK06769 1279365006380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365006381 active site 1279365006382 motif I; other site 1279365006383 motif II; other site 1279365006384 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365006385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006386 Coenzyme A binding pocket [chemical binding]; other site 1279365006387 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1279365006388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365006389 Walker A/P-loop; other site 1279365006390 ATP binding site [chemical binding]; other site 1279365006391 Q-loop/lid; other site 1279365006392 ABC transporter signature motif; other site 1279365006393 Walker B; other site 1279365006394 D-loop; other site 1279365006395 H-loop/switch region; other site 1279365006396 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1279365006397 YpjP-like protein; Region: YpjP; pfam14005 1279365006398 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1279365006399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365006400 motif II; other site 1279365006401 hypothetical protein; Provisional; Region: PRK06724 1279365006402 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365006403 active site 1279365006404 metal binding site [ion binding]; metal-binding site 1279365006405 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365006406 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1279365006407 active site 1279365006408 substrate binding site [chemical binding]; other site 1279365006409 ATP binding site [chemical binding]; other site 1279365006410 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365006411 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365006412 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1279365006413 thymidylate synthase; Region: thym_sym; TIGR03284 1279365006414 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1279365006415 dimerization interface [polypeptide binding]; other site 1279365006416 active site 1279365006417 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1279365006418 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1279365006419 folate binding site [chemical binding]; other site 1279365006420 NADP+ binding site [chemical binding]; other site 1279365006421 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1279365006422 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365006423 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1279365006424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365006425 azoreductase; Reviewed; Region: PRK00170 1279365006426 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1279365006427 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1279365006428 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1279365006429 putative acyl-acceptor binding pocket; other site 1279365006430 Haemolysin-III related; Region: HlyIII; cl03831 1279365006431 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1279365006432 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1279365006433 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1279365006434 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1279365006435 EDD domain protein, DegV family; Region: DegV; TIGR00762 1279365006436 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1279365006437 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1279365006438 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1279365006439 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1279365006440 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1279365006441 Cu(I) binding site [ion binding]; other site 1279365006442 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1279365006443 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1279365006444 putative dimer interface [polypeptide binding]; other site 1279365006445 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1279365006446 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1279365006447 active site 1279365006448 dimer interface [polypeptide binding]; other site 1279365006449 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1279365006450 Ligand Binding Site [chemical binding]; other site 1279365006451 Molecular Tunnel; other site 1279365006452 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365006453 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1279365006454 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1279365006455 active site 1279365006456 metal binding site [ion binding]; metal-binding site 1279365006457 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1279365006458 Bacterial SH3 domain; Region: SH3_3; cl17532 1279365006459 Bacterial SH3 domain; Region: SH3_3; cl17532 1279365006460 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365006461 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1279365006462 siderophore binding site; other site 1279365006463 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1279365006464 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1279365006465 homodimer interface [polypeptide binding]; other site 1279365006466 substrate-cofactor binding pocket; other site 1279365006467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365006468 catalytic residue [active] 1279365006469 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1279365006470 FMN binding site [chemical binding]; other site 1279365006471 dimer interface [polypeptide binding]; other site 1279365006472 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365006473 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1279365006474 catalytic triad [active] 1279365006475 conserved cis-peptide bond; other site 1279365006476 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1279365006477 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1279365006478 putative dimer interface [polypeptide binding]; other site 1279365006479 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1279365006480 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1279365006481 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1279365006482 GAF domain; Region: GAF; pfam01590 1279365006483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365006484 Histidine kinase; Region: HisKA_3; pfam07730 1279365006485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365006486 ATP binding site [chemical binding]; other site 1279365006487 Mg2+ binding site [ion binding]; other site 1279365006488 G-X-G motif; other site 1279365006489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365006490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365006491 active site 1279365006492 phosphorylation site [posttranslational modification] 1279365006493 intermolecular recognition site; other site 1279365006494 dimerization interface [polypeptide binding]; other site 1279365006495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365006496 DNA binding residues [nucleotide binding] 1279365006497 dimerization interface [polypeptide binding]; other site 1279365006498 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1279365006499 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1279365006500 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1279365006501 putative active site [active] 1279365006502 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1279365006503 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1279365006504 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1279365006505 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1279365006506 NAD binding site [chemical binding]; other site 1279365006507 substrate binding site [chemical binding]; other site 1279365006508 catalytic Zn binding site [ion binding]; other site 1279365006509 tetramer interface [polypeptide binding]; other site 1279365006510 structural Zn binding site [ion binding]; other site 1279365006511 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1279365006512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365006513 dimer interface [polypeptide binding]; other site 1279365006514 conserved gate region; other site 1279365006515 ABC-ATPase subunit interface; other site 1279365006516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365006517 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1279365006518 dimer interface [polypeptide binding]; other site 1279365006519 conserved gate region; other site 1279365006520 putative PBP binding loops; other site 1279365006521 ABC-ATPase subunit interface; other site 1279365006522 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1279365006523 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1279365006524 N- and C-terminal domain interface [polypeptide binding]; other site 1279365006525 active site 1279365006526 catalytic site [active] 1279365006527 metal binding site [ion binding]; metal-binding site 1279365006528 carbohydrate binding site [chemical binding]; other site 1279365006529 ATP binding site [chemical binding]; other site 1279365006530 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1279365006531 GntP family permease; Region: GntP_permease; pfam02447 1279365006532 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1279365006533 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1279365006534 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1279365006535 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365006536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365006537 active site 1279365006538 Predicted flavoprotein [General function prediction only]; Region: COG0431 1279365006539 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1279365006540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006541 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365006542 putative substrate translocation pore; other site 1279365006543 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1279365006544 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1279365006545 putative active site [active] 1279365006546 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1279365006547 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1279365006548 Walker A/P-loop; other site 1279365006549 ATP binding site [chemical binding]; other site 1279365006550 Q-loop/lid; other site 1279365006551 ABC transporter signature motif; other site 1279365006552 Walker B; other site 1279365006553 D-loop; other site 1279365006554 H-loop/switch region; other site 1279365006555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365006556 dimer interface [polypeptide binding]; other site 1279365006557 conserved gate region; other site 1279365006558 ABC-ATPase subunit interface; other site 1279365006559 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1279365006560 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1279365006561 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1279365006562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1279365006563 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1279365006564 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1279365006565 Helix-turn-helix domain; Region: HTH_17; pfam12728 1279365006566 Haemagglutinin; Region: Hemagglutinin; pfam00509 1279365006567 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1279365006568 Domain of unknown function DUF21; Region: DUF21; pfam01595 1279365006569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1279365006570 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1279365006571 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1279365006572 NAD(P) binding site [chemical binding]; other site 1279365006573 catalytic residues [active] 1279365006574 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1279365006575 Histidine kinase N terminal; Region: HisK_N; pfam09385 1279365006576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365006577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365006578 dimer interface [polypeptide binding]; other site 1279365006579 phosphorylation site [posttranslational modification] 1279365006580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365006581 ATP binding site [chemical binding]; other site 1279365006582 Mg2+ binding site [ion binding]; other site 1279365006583 G-X-G motif; other site 1279365006584 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1279365006585 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1279365006586 hypothetical protein; Provisional; Region: PRK06917 1279365006587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365006588 inhibitor-cofactor binding pocket; inhibition site 1279365006589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365006590 catalytic residue [active] 1279365006591 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1279365006592 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1279365006593 acetylornithine deacetylase; Validated; Region: PRK06915 1279365006594 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1279365006595 metal binding site [ion binding]; metal-binding site 1279365006596 dimer interface [polypeptide binding]; other site 1279365006597 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1279365006598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365006599 PAS fold; Region: PAS_4; pfam08448 1279365006600 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1279365006601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365006602 Walker A motif; other site 1279365006603 ATP binding site [chemical binding]; other site 1279365006604 Walker B motif; other site 1279365006605 arginine finger; other site 1279365006606 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1279365006607 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1279365006608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365006609 FeS/SAM binding site; other site 1279365006610 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1279365006611 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1279365006612 toxin interface [polypeptide binding]; other site 1279365006613 Zn binding site [ion binding]; other site 1279365006614 hypothetical protein; Provisional; Region: PRK13672 1279365006615 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 1279365006616 YozD-like protein; Region: YozD; pfam14162 1279365006617 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1279365006618 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1279365006619 active site 1279365006620 ATP binding site [chemical binding]; other site 1279365006621 substrate binding site [chemical binding]; other site 1279365006622 activation loop (A-loop); other site 1279365006623 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1279365006624 SpoOM protein; Region: Spo0M; pfam07070 1279365006625 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1279365006626 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1279365006627 active site 1279365006628 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1279365006629 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1279365006630 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365006631 catalytic residues [active] 1279365006632 C1q domain; Region: C1q; cl17543 1279365006633 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1279365006634 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1279365006635 active site 1279365006636 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1279365006637 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1279365006638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365006639 Integrase core domain; Region: rve; pfam00665 1279365006640 transposase/IS protein; Provisional; Region: PRK09183 1279365006641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365006642 Walker A motif; other site 1279365006643 ATP binding site [chemical binding]; other site 1279365006644 Walker B motif; other site 1279365006645 arginine finger; other site 1279365006646 YolD-like protein; Region: YolD; pfam08863 1279365006647 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365006648 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1279365006649 classical (c) SDRs; Region: SDR_c; cd05233 1279365006650 NAD(P) binding site [chemical binding]; other site 1279365006651 active site 1279365006652 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1279365006653 Transglycosylase; Region: Transgly; pfam00912 1279365006654 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1279365006655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365006656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365006658 putative substrate translocation pore; other site 1279365006659 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1279365006660 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1279365006661 dimer interface [polypeptide binding]; other site 1279365006662 Citrate synthase; Region: Citrate_synt; pfam00285 1279365006663 active site 1279365006664 coenzyme A binding site [chemical binding]; other site 1279365006665 citrylCoA binding site [chemical binding]; other site 1279365006666 oxalacetate/citrate binding site [chemical binding]; other site 1279365006667 catalytic triad [active] 1279365006668 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1279365006669 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1279365006670 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1279365006671 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1279365006672 tetramer interface [polypeptide binding]; other site 1279365006673 active site 1279365006674 Mg2+/Mn2+ binding site [ion binding]; other site 1279365006675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1279365006676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1279365006677 active site 1279365006678 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1279365006679 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1279365006680 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1279365006681 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1279365006682 tetrameric interface [polypeptide binding]; other site 1279365006683 NAD binding site [chemical binding]; other site 1279365006684 catalytic residues [active] 1279365006685 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1279365006686 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1279365006687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1279365006688 substrate binding site [chemical binding]; other site 1279365006689 oxyanion hole (OAH) forming residues; other site 1279365006690 trimer interface [polypeptide binding]; other site 1279365006691 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1279365006692 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1279365006693 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1279365006694 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1279365006695 active site 1279365006696 metal binding site [ion binding]; metal-binding site 1279365006697 DNA binding site [nucleotide binding] 1279365006698 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1279365006699 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1279365006700 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1279365006701 Walker A/P-loop; other site 1279365006702 ATP binding site [chemical binding]; other site 1279365006703 Q-loop/lid; other site 1279365006704 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1279365006705 ABC transporter signature motif; other site 1279365006706 Walker B; other site 1279365006707 D-loop; other site 1279365006708 H-loop/switch region; other site 1279365006709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365006710 dimerization interface [polypeptide binding]; other site 1279365006711 putative DNA binding site [nucleotide binding]; other site 1279365006712 putative Zn2+ binding site [ion binding]; other site 1279365006713 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1279365006714 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1279365006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006716 putative substrate translocation pore; other site 1279365006717 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1279365006718 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1279365006719 putative NAD(P) binding site [chemical binding]; other site 1279365006720 active site 1279365006721 isochorismate synthase DhbC; Validated; Region: PRK06923 1279365006722 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1279365006723 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1279365006724 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1279365006725 acyl-activating enzyme (AAE) consensus motif; other site 1279365006726 active site 1279365006727 AMP binding site [chemical binding]; other site 1279365006728 substrate binding site [chemical binding]; other site 1279365006729 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1279365006730 hydrophobic substrate binding pocket; other site 1279365006731 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365006732 active site 1279365006733 conserved cis-peptide bond; other site 1279365006734 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1279365006735 Condensation domain; Region: Condensation; pfam00668 1279365006736 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1279365006737 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1279365006738 acyl-activating enzyme (AAE) consensus motif; other site 1279365006739 AMP binding site [chemical binding]; other site 1279365006740 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365006741 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1279365006742 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1279365006743 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365006744 acyl-activating enzyme (AAE) consensus motif; other site 1279365006745 AMP binding site [chemical binding]; other site 1279365006746 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365006747 MbtH-like protein; Region: MbtH; pfam03621 1279365006748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365006750 putative substrate translocation pore; other site 1279365006751 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1279365006752 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1279365006753 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1279365006754 IHF dimer interface [polypeptide binding]; other site 1279365006755 IHF - DNA interface [nucleotide binding]; other site 1279365006756 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1279365006757 DinB family; Region: DinB; cl17821 1279365006758 DinB superfamily; Region: DinB_2; pfam12867 1279365006759 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1279365006760 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1279365006761 active site 1279365006762 catalytic triad [active] 1279365006763 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365006764 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1279365006765 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365006766 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1279365006767 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365006768 RNA binding surface [nucleotide binding]; other site 1279365006769 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1279365006770 probable active site [active] 1279365006771 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1279365006772 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1279365006773 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1279365006774 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1279365006775 active site 1279365006776 dimer interface [polypeptide binding]; other site 1279365006777 motif 1; other site 1279365006778 motif 2; other site 1279365006779 motif 3; other site 1279365006780 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1279365006781 anticodon binding site; other site 1279365006782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365006783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365006784 Walker A/P-loop; other site 1279365006785 ATP binding site [chemical binding]; other site 1279365006786 Q-loop/lid; other site 1279365006787 ABC transporter signature motif; other site 1279365006788 Walker B; other site 1279365006789 D-loop; other site 1279365006790 H-loop/switch region; other site 1279365006791 FtsX-like permease family; Region: FtsX; pfam02687 1279365006792 pyruvate oxidase; Provisional; Region: PRK08611 1279365006793 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1279365006794 PYR/PP interface [polypeptide binding]; other site 1279365006795 dimer interface [polypeptide binding]; other site 1279365006796 tetramer interface [polypeptide binding]; other site 1279365006797 TPP binding site [chemical binding]; other site 1279365006798 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1279365006799 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1279365006800 TPP-binding site [chemical binding]; other site 1279365006801 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1279365006802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365006803 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1279365006804 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1279365006805 active site 1279365006806 dimerization interface [polypeptide binding]; other site 1279365006807 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 1279365006808 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1279365006809 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1279365006810 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365006811 ligand binding site [chemical binding]; other site 1279365006812 flexible hinge region; other site 1279365006813 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1279365006814 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1279365006815 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1279365006816 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1279365006817 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1279365006818 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1279365006819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1279365006820 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365006821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365006822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365006823 MMPL family; Region: MMPL; pfam03176 1279365006824 MMPL family; Region: MMPL; pfam03176 1279365006825 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 1279365006826 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 1279365006827 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1279365006828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006829 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365006830 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365006831 Coenzyme A binding pocket [chemical binding]; other site 1279365006832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365006833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006834 Coenzyme A binding pocket [chemical binding]; other site 1279365006835 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1279365006836 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1279365006837 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1279365006838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006839 Coenzyme A binding pocket [chemical binding]; other site 1279365006840 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365006841 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1279365006842 EamA-like transporter family; Region: EamA; pfam00892 1279365006843 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1279365006844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365006845 non-specific DNA binding site [nucleotide binding]; other site 1279365006846 salt bridge; other site 1279365006847 sequence-specific DNA binding site [nucleotide binding]; other site 1279365006848 Cupin domain; Region: Cupin_2; pfam07883 1279365006849 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1279365006850 protoporphyrinogen oxidase; Provisional; Region: PRK12416 1279365006851 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365006852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365006853 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365006854 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1279365006855 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1279365006856 DNA-binding site [nucleotide binding]; DNA binding site 1279365006857 RNA-binding motif; other site 1279365006858 CAAX protease self-immunity; Region: Abi; pfam02517 1279365006859 AAA domain; Region: AAA_17; pfam13207 1279365006860 AAA domain; Region: AAA_18; pfam13238 1279365006861 hypothetical protein; Provisional; Region: PRK06770 1279365006862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365006863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365006864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365006865 dimerization interface [polypeptide binding]; other site 1279365006866 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 1279365006867 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1279365006868 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1279365006869 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1279365006870 active site 1279365006871 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1279365006872 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1279365006873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365006874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365006875 dimerization interface [polypeptide binding]; other site 1279365006876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1279365006877 MOSC domain; Region: MOSC; pfam03473 1279365006878 3-alpha domain; Region: 3-alpha; pfam03475 1279365006879 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1279365006880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365006881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365006882 Coenzyme A binding pocket [chemical binding]; other site 1279365006883 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1279365006884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365006885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365006886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365006887 Walker A/P-loop; other site 1279365006888 ATP binding site [chemical binding]; other site 1279365006889 Q-loop/lid; other site 1279365006890 ABC transporter signature motif; other site 1279365006891 Walker B; other site 1279365006892 D-loop; other site 1279365006893 H-loop/switch region; other site 1279365006894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365006895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365006896 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1279365006897 Walker A/P-loop; other site 1279365006898 ATP binding site [chemical binding]; other site 1279365006899 Q-loop/lid; other site 1279365006900 ABC transporter signature motif; other site 1279365006901 Walker B; other site 1279365006902 D-loop; other site 1279365006903 H-loop/switch region; other site 1279365006904 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1279365006905 LysE type translocator; Region: LysE; cl00565 1279365006906 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1279365006907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365006908 non-specific DNA binding site [nucleotide binding]; other site 1279365006909 salt bridge; other site 1279365006910 sequence-specific DNA binding site [nucleotide binding]; other site 1279365006911 Cupin domain; Region: Cupin_2; pfam07883 1279365006912 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1279365006913 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1279365006914 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1279365006915 Cupin; Region: Cupin_1; smart00835 1279365006916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365006917 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1279365006918 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1279365006919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365006920 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1279365006921 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1279365006922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365006923 S-adenosylmethionine binding site [chemical binding]; other site 1279365006924 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1279365006925 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 1279365006926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1279365006927 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1279365006928 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1279365006929 active site 1279365006930 P-loop; other site 1279365006931 phosphorylation site [posttranslational modification] 1279365006932 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1279365006933 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1279365006934 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1279365006935 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1279365006936 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1279365006937 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1279365006938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1279365006939 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1279365006940 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365006941 catalytic residue [active] 1279365006942 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1279365006943 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1279365006944 tetramer interface [polypeptide binding]; other site 1279365006945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365006946 catalytic residue [active] 1279365006947 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365006948 MarR family; Region: MarR; pfam01047 1279365006949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365006950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006951 putative substrate translocation pore; other site 1279365006952 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1279365006953 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1279365006954 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1279365006955 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1279365006956 ATP binding site [chemical binding]; other site 1279365006957 Mg++ binding site [ion binding]; other site 1279365006958 motif III; other site 1279365006959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365006960 nucleotide binding region [chemical binding]; other site 1279365006961 ATP-binding site [chemical binding]; other site 1279365006962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365006963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365006964 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365006965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365006966 putative substrate translocation pore; other site 1279365006967 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365006968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365006969 S-adenosylmethionine binding site [chemical binding]; other site 1279365006970 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1279365006971 dimer interface [polypeptide binding]; other site 1279365006972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365006973 S-adenosylmethionine binding site [chemical binding]; other site 1279365006974 cell division protein FtsZ; Region: ftsZ; TIGR00065 1279365006975 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1279365006976 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1279365006977 dimer interface [polypeptide binding]; other site 1279365006978 PYR/PP interface [polypeptide binding]; other site 1279365006979 TPP binding site [chemical binding]; other site 1279365006980 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1279365006981 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1279365006982 TPP-binding site [chemical binding]; other site 1279365006983 dimer interface [polypeptide binding]; other site 1279365006984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365006985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365006986 putative DNA binding site [nucleotide binding]; other site 1279365006987 putative Zn2+ binding site [ion binding]; other site 1279365006988 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365006989 catalytic core [active] 1279365006990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365006991 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1279365006992 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1279365006993 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1279365006994 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1279365006995 metal binding site [ion binding]; metal-binding site 1279365006996 dimer interface [polypeptide binding]; other site 1279365006997 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1279365006998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365006999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365007000 DNA binding residues [nucleotide binding] 1279365007001 dimerization interface [polypeptide binding]; other site 1279365007002 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365007003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365007004 non-specific DNA binding site [nucleotide binding]; other site 1279365007005 salt bridge; other site 1279365007006 sequence-specific DNA binding site [nucleotide binding]; other site 1279365007007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365007008 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1279365007009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365007010 Transposase; Region: HTH_Tnp_1; cl17663 1279365007011 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365007012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365007013 HTH-like domain; Region: HTH_21; pfam13276 1279365007014 Integrase core domain; Region: rve; pfam00665 1279365007015 Integrase core domain; Region: rve_2; pfam13333 1279365007016 hypothetical protein; Provisional; Region: PRK10621 1279365007017 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365007018 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1279365007019 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1279365007020 trimer interface [polypeptide binding]; other site 1279365007021 active site 1279365007022 substrate binding site [chemical binding]; other site 1279365007023 CoA binding site [chemical binding]; other site 1279365007024 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1279365007025 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365007026 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1279365007027 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1279365007028 active site 1279365007029 catalytic triad [active] 1279365007030 oxyanion hole [active] 1279365007031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007032 putative substrate translocation pore; other site 1279365007033 Condensation domain; Region: Condensation; pfam00668 1279365007034 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1279365007035 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1279365007036 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365007037 acyl-activating enzyme (AAE) consensus motif; other site 1279365007038 AMP binding site [chemical binding]; other site 1279365007039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007040 Condensation domain; Region: Condensation; pfam00668 1279365007041 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1279365007042 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1279365007043 Condensation domain; Region: Condensation; pfam00668 1279365007044 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1279365007045 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365007046 acyl-activating enzyme (AAE) consensus motif; other site 1279365007047 AMP binding site [chemical binding]; other site 1279365007048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007049 Condensation domain; Region: Condensation; pfam00668 1279365007050 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1279365007051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1279365007052 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1279365007053 acyl-activating enzyme (AAE) consensus motif; other site 1279365007054 AMP binding site [chemical binding]; other site 1279365007055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007056 Condensation domain; Region: Condensation; pfam00668 1279365007057 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1279365007058 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1279365007059 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365007060 acyl-activating enzyme (AAE) consensus motif; other site 1279365007061 AMP binding site [chemical binding]; other site 1279365007062 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007063 peptide synthase; Provisional; Region: PRK12467 1279365007064 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1279365007065 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365007066 acyl-activating enzyme (AAE) consensus motif; other site 1279365007067 AMP binding site [chemical binding]; other site 1279365007068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007069 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1279365007070 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365007071 acyl-activating enzyme (AAE) consensus motif; other site 1279365007072 AMP binding site [chemical binding]; other site 1279365007073 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007074 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1279365007075 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365007076 acyl-activating enzyme (AAE) consensus motif; other site 1279365007077 AMP binding site [chemical binding]; other site 1279365007078 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365007079 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1279365007080 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1279365007081 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1279365007082 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1279365007083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365007084 NAD(P) binding site [chemical binding]; other site 1279365007085 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1279365007086 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1279365007087 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1279365007088 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1279365007089 catalytic residue [active] 1279365007090 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1279365007091 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365007092 putative active site [active] 1279365007093 putative NTP binding site [chemical binding]; other site 1279365007094 putative nucleic acid binding site [nucleotide binding]; other site 1279365007095 Type II intron maturase; Region: Intron_maturas2; pfam01348 1279365007096 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365007097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007098 Coenzyme A binding pocket [chemical binding]; other site 1279365007099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365007100 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1279365007101 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1279365007102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1279365007103 Divalent cation transporter; Region: MgtE; cl00786 1279365007104 magnesium-transporting ATPase; Provisional; Region: PRK15122 1279365007105 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1279365007106 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365007107 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1279365007108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365007109 motif II; other site 1279365007110 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1279365007111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007112 dimerization interface [polypeptide binding]; other site 1279365007113 putative DNA binding site [nucleotide binding]; other site 1279365007114 putative Zn2+ binding site [ion binding]; other site 1279365007115 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1279365007116 putative pectinesterase; Region: PLN02432; cl01911 1279365007117 Right handed beta helix region; Region: Beta_helix; pfam13229 1279365007118 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007119 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007120 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007121 transposase/IS protein; Provisional; Region: PRK09183 1279365007122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365007123 Walker A motif; other site 1279365007124 ATP binding site [chemical binding]; other site 1279365007125 Walker B motif; other site 1279365007126 arginine finger; other site 1279365007127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365007128 Integrase core domain; Region: rve; pfam00665 1279365007129 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365007130 substrate binding site [chemical binding]; other site 1279365007131 amidase catalytic site [active] 1279365007132 Zn binding residues [ion binding]; other site 1279365007133 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365007134 S-layer homology domain; Region: SLH; pfam00395 1279365007135 S-layer homology domain; Region: SLH; pfam00395 1279365007136 S-layer homology domain; Region: SLH; pfam00395 1279365007137 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1279365007138 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1279365007139 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1279365007140 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1279365007141 homodimer interface [polypeptide binding]; other site 1279365007142 substrate-cofactor binding pocket; other site 1279365007143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365007144 catalytic residue [active] 1279365007145 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1279365007146 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1279365007147 putative ligand binding site [chemical binding]; other site 1279365007148 putative NAD binding site [chemical binding]; other site 1279365007149 putative catalytic site [active] 1279365007150 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1279365007151 L-serine binding site [chemical binding]; other site 1279365007152 ACT domain interface; other site 1279365007153 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1279365007154 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1279365007155 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1279365007156 dimer interaction site [polypeptide binding]; other site 1279365007157 substrate-binding tunnel; other site 1279365007158 active site 1279365007159 catalytic site [active] 1279365007160 substrate binding site [chemical binding]; other site 1279365007161 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1279365007162 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 1279365007163 2TM domain; Region: 2TM; pfam13239 1279365007164 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365007165 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365007166 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365007167 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365007168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365007169 active site 1279365007170 phosphorylation site [posttranslational modification] 1279365007171 intermolecular recognition site; other site 1279365007172 dimerization interface [polypeptide binding]; other site 1279365007173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365007174 DNA binding site [nucleotide binding] 1279365007175 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1279365007176 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365007177 dimerization interface [polypeptide binding]; other site 1279365007178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365007179 dimer interface [polypeptide binding]; other site 1279365007180 phosphorylation site [posttranslational modification] 1279365007181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365007182 ATP binding site [chemical binding]; other site 1279365007183 Mg2+ binding site [ion binding]; other site 1279365007184 G-X-G motif; other site 1279365007185 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1279365007186 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365007187 FtsX-like permease family; Region: FtsX; pfam02687 1279365007188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365007189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365007190 Walker A/P-loop; other site 1279365007191 ATP binding site [chemical binding]; other site 1279365007192 Q-loop/lid; other site 1279365007193 ABC transporter signature motif; other site 1279365007194 Walker B; other site 1279365007195 D-loop; other site 1279365007196 H-loop/switch region; other site 1279365007197 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 1279365007198 hypothetical protein; Provisional; Region: PRK06762 1279365007199 AAA domain; Region: AAA_33; pfam13671 1279365007200 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1279365007201 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1279365007202 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1279365007203 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1279365007204 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1279365007205 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365007206 active site 1279365007207 metal binding site [ion binding]; metal-binding site 1279365007208 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1279365007209 D-cysteine desulfhydrase; Validated; Region: PRK03910 1279365007210 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1279365007211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365007212 catalytic residue [active] 1279365007213 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1279365007214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007215 putative substrate translocation pore; other site 1279365007216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007217 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1279365007218 Cytochrome P450; Region: p450; pfam00067 1279365007219 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1279365007220 Flavodoxin; Region: Flavodoxin_1; pfam00258 1279365007221 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1279365007222 FAD binding pocket [chemical binding]; other site 1279365007223 FAD binding motif [chemical binding]; other site 1279365007224 catalytic residues [active] 1279365007225 NAD binding pocket [chemical binding]; other site 1279365007226 phosphate binding motif [ion binding]; other site 1279365007227 beta-alpha-beta structure motif; other site 1279365007228 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1279365007229 putative metal binding site [ion binding]; other site 1279365007230 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1279365007231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365007232 Histidine kinase; Region: HisKA_3; pfam07730 1279365007233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365007234 ATP binding site [chemical binding]; other site 1279365007235 Mg2+ binding site [ion binding]; other site 1279365007236 G-X-G motif; other site 1279365007237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365007238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365007239 active site 1279365007240 phosphorylation site [posttranslational modification] 1279365007241 intermolecular recognition site; other site 1279365007242 dimerization interface [polypeptide binding]; other site 1279365007243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365007244 DNA binding residues [nucleotide binding] 1279365007245 dimerization interface [polypeptide binding]; other site 1279365007246 Putative sensor; Region: Sensor; pfam13796 1279365007247 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1279365007248 Erythromycin esterase; Region: Erythro_esteras; cl17110 1279365007249 CAAX protease self-immunity; Region: Abi; pfam02517 1279365007250 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1279365007251 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1279365007252 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1279365007253 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 1279365007254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365007255 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1279365007256 active site 1279365007257 metal binding site [ion binding]; metal-binding site 1279365007258 AAA domain; Region: AAA_11; pfam13086 1279365007259 Part of AAA domain; Region: AAA_19; pfam13245 1279365007260 Erp protein C-terminus; Region: Erp_C; pfam06780 1279365007261 AAA domain; Region: AAA_30; pfam13604 1279365007262 AAA domain; Region: AAA_12; pfam13087 1279365007263 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1279365007264 putative active site [active] 1279365007265 catalytic site [active] 1279365007266 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1279365007267 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1279365007268 metal binding site [ion binding]; metal-binding site 1279365007269 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1279365007270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007271 putative DNA binding site [nucleotide binding]; other site 1279365007272 putative Zn2+ binding site [ion binding]; other site 1279365007273 AsnC family; Region: AsnC_trans_reg; pfam01037 1279365007274 short chain dehydrogenase; Provisional; Region: PRK12746 1279365007275 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1279365007276 NADP binding site [chemical binding]; other site 1279365007277 homodimer interface [polypeptide binding]; other site 1279365007278 active site 1279365007279 substrate binding site [chemical binding]; other site 1279365007280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365007281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365007282 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1279365007283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007284 putative substrate translocation pore; other site 1279365007285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007286 dimerization interface [polypeptide binding]; other site 1279365007287 putative DNA binding site [nucleotide binding]; other site 1279365007288 putative Zn2+ binding site [ion binding]; other site 1279365007289 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1279365007290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365007291 putative metal binding site [ion binding]; other site 1279365007292 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1279365007293 arsenical-resistance protein; Region: acr3; TIGR00832 1279365007294 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1279365007295 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1279365007296 active site 1279365007297 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1279365007298 DJ-1 family protein; Region: not_thiJ; TIGR01383 1279365007299 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1279365007300 conserved cys residue [active] 1279365007301 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1279365007302 UbiA prenyltransferase family; Region: UbiA; pfam01040 1279365007303 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365007304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007305 Coenzyme A binding pocket [chemical binding]; other site 1279365007306 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365007307 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1279365007308 NodB motif; other site 1279365007309 active site 1279365007310 catalytic site [active] 1279365007311 Zn binding site [ion binding]; other site 1279365007312 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1279365007313 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1279365007314 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1279365007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1279365007316 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1279365007317 Carbonic anhydrase; Region: Pro_CA; pfam00484 1279365007318 zinc binding site [ion binding]; other site 1279365007319 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1279365007320 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1279365007321 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1279365007322 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1279365007323 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 1279365007324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365007325 MarR family; Region: MarR_2; pfam12802 1279365007326 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1279365007327 NmrA-like family; Region: NmrA; pfam05368 1279365007328 NADP binding site [chemical binding]; other site 1279365007329 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1279365007330 DNA photolyase; Region: DNA_photolyase; pfam00875 1279365007331 TspO/MBR family; Region: TspO_MBR; pfam03073 1279365007332 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1279365007333 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1279365007334 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1279365007335 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1279365007336 Heat induced stress protein YflT; Region: YflT; pfam11181 1279365007337 plasmid segregation protein ParM; Provisional; Region: PRK13917 1279365007338 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1279365007339 Mg binding site [ion binding]; other site 1279365007340 nucleotide binding site [chemical binding]; other site 1279365007341 putative protofilament interface [polypeptide binding]; other site 1279365007342 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1279365007343 Cl binding site [ion binding]; other site 1279365007344 oligomer interface [polypeptide binding]; other site 1279365007345 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1279365007346 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1279365007347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365007348 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1279365007349 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1279365007350 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365007351 FOG: PKD repeat [General function prediction only]; Region: COG3291 1279365007352 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1279365007353 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1279365007354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365007355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365007356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365007357 dimerization interface [polypeptide binding]; other site 1279365007358 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1279365007359 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1279365007360 active site 1279365007361 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1279365007362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1279365007363 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365007364 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1279365007365 catalytic triad [active] 1279365007366 dimer interface [polypeptide binding]; other site 1279365007367 conserved cis-peptide bond; other site 1279365007368 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365007369 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1279365007370 catalytic triad [active] 1279365007371 dimer interface [polypeptide binding]; other site 1279365007372 conserved cis-peptide bond; other site 1279365007373 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365007374 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365007375 TAP-like protein; Region: Abhydrolase_4; pfam08386 1279365007376 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1279365007377 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1279365007378 putative active site [active] 1279365007379 putative metal binding site [ion binding]; other site 1279365007380 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1279365007381 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 1279365007382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365007383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365007384 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007385 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007386 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007387 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007388 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 1279365007389 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1279365007390 PAS fold; Region: PAS_4; pfam08448 1279365007391 PAS domain S-box; Region: sensory_box; TIGR00229 1279365007392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365007393 putative active site [active] 1279365007394 heme pocket [chemical binding]; other site 1279365007395 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1279365007396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365007397 putative active site [active] 1279365007398 heme pocket [chemical binding]; other site 1279365007399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365007400 dimer interface [polypeptide binding]; other site 1279365007401 phosphorylation site [posttranslational modification] 1279365007402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365007403 ATP binding site [chemical binding]; other site 1279365007404 Mg2+ binding site [ion binding]; other site 1279365007405 G-X-G motif; other site 1279365007406 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1279365007407 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1279365007408 NAD binding site [chemical binding]; other site 1279365007409 catalytic Zn binding site [ion binding]; other site 1279365007410 structural Zn binding site [ion binding]; other site 1279365007411 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1279365007412 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1279365007413 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1279365007414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365007415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365007416 NAD(P) binding site [chemical binding]; other site 1279365007417 active site 1279365007418 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1279365007419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007420 putative DNA binding site [nucleotide binding]; other site 1279365007421 putative Zn2+ binding site [ion binding]; other site 1279365007422 AsnC family; Region: AsnC_trans_reg; pfam01037 1279365007423 DJ-1 family protein; Region: not_thiJ; TIGR01383 1279365007424 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1279365007425 conserved cys residue [active] 1279365007426 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1279365007427 YolD-like protein; Region: YolD; pfam08863 1279365007428 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1279365007429 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1279365007430 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1279365007431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365007432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365007433 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1279365007434 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1279365007435 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1279365007436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365007437 Transposase; Region: HTH_Tnp_1; cl17663 1279365007438 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365007439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365007440 HTH-like domain; Region: HTH_21; pfam13276 1279365007441 Integrase core domain; Region: rve; pfam00665 1279365007442 Integrase core domain; Region: rve_2; pfam13333 1279365007443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365007444 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365007445 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1279365007446 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1279365007447 dinuclear metal binding motif [ion binding]; other site 1279365007448 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1279365007449 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365007450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007451 Coenzyme A binding pocket [chemical binding]; other site 1279365007452 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1279365007453 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365007454 putative active site [active] 1279365007455 putative substrate binding site [chemical binding]; other site 1279365007456 ATP binding site [chemical binding]; other site 1279365007457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1279365007458 Nucleoside recognition; Region: Gate; pfam07670 1279365007459 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365007460 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365007461 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1279365007462 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1279365007463 putative active site [active] 1279365007464 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1279365007465 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1279365007466 active site 1279365007467 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1279365007468 DinB superfamily; Region: DinB_2; pfam12867 1279365007469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007470 dimerization interface [polypeptide binding]; other site 1279365007471 putative DNA binding site [nucleotide binding]; other site 1279365007472 putative Zn2+ binding site [ion binding]; other site 1279365007473 CutC family; Region: CutC; cl01218 1279365007474 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1279365007475 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365007476 Catalytic site [active] 1279365007477 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1279365007478 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1279365007479 Bacterial transcriptional regulator; Region: IclR; pfam01614 1279365007480 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1279365007481 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1279365007482 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1279365007483 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1279365007484 putative active site [active] 1279365007485 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1279365007486 Predicted membrane protein [Function unknown]; Region: COG3817 1279365007487 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1279365007488 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1279365007489 putative substrate binding pocket [chemical binding]; other site 1279365007490 AC domain interface; other site 1279365007491 catalytic triad [active] 1279365007492 AB domain interface; other site 1279365007493 interchain disulfide; other site 1279365007494 NAD-dependent deacetylase; Provisional; Region: PRK00481 1279365007495 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 1279365007496 NAD+ binding site [chemical binding]; other site 1279365007497 substrate binding site [chemical binding]; other site 1279365007498 Zn binding site [ion binding]; other site 1279365007499 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365007500 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365007501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365007502 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1279365007503 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365007504 Catalytic site [active] 1279365007505 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1279365007506 putative active site [active] 1279365007507 nucleotide binding site [chemical binding]; other site 1279365007508 nudix motif; other site 1279365007509 putative metal binding site [ion binding]; other site 1279365007510 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365007511 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1279365007512 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1279365007513 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1279365007514 lysine transporter; Provisional; Region: PRK10836 1279365007515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365007516 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365007517 Coenzyme A binding pocket [chemical binding]; other site 1279365007518 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365007519 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1279365007520 active site 1279365007521 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365007522 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365007523 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365007524 active site 1279365007525 ATP binding site [chemical binding]; other site 1279365007526 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1279365007527 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365007528 active site 1279365007529 metal binding site [ion binding]; metal-binding site 1279365007530 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1279365007531 active site 1279365007532 uridine kinase; Validated; Region: PRK06696 1279365007533 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1279365007534 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1279365007535 hypothetical protein; Validated; Region: PRK00124 1279365007536 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365007537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365007538 DNA-binding site [nucleotide binding]; DNA binding site 1279365007539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365007540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365007541 homodimer interface [polypeptide binding]; other site 1279365007542 catalytic residue [active] 1279365007543 EamA-like transporter family; Region: EamA; pfam00892 1279365007544 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365007545 EamA-like transporter family; Region: EamA; pfam00892 1279365007546 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1279365007547 nudix motif; other site 1279365007548 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 1279365007549 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365007550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007551 Coenzyme A binding pocket [chemical binding]; other site 1279365007552 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1279365007553 nucleoside/Zn binding site; other site 1279365007554 dimer interface [polypeptide binding]; other site 1279365007555 catalytic motif [active] 1279365007556 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1279365007557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365007558 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1279365007559 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365007560 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365007561 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1279365007562 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1279365007563 putative NAD(P) binding site [chemical binding]; other site 1279365007564 active site 1279365007565 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1279365007566 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1279365007567 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1279365007568 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1279365007569 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1279365007570 nudix motif; other site 1279365007571 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1279365007572 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1279365007573 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1279365007574 G1 box; other site 1279365007575 putative GEF interaction site [polypeptide binding]; other site 1279365007576 GTP/Mg2+ binding site [chemical binding]; other site 1279365007577 Switch I region; other site 1279365007578 G2 box; other site 1279365007579 G3 box; other site 1279365007580 Switch II region; other site 1279365007581 G4 box; other site 1279365007582 G5 box; other site 1279365007583 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1279365007584 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1279365007585 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1279365007586 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365007587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007588 putative DNA binding site [nucleotide binding]; other site 1279365007589 putative Zn2+ binding site [ion binding]; other site 1279365007590 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1279365007591 dimer interface [polypeptide binding]; other site 1279365007592 FMN binding site [chemical binding]; other site 1279365007593 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1279365007594 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1279365007595 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 1279365007596 LXG domain of WXG superfamily; Region: LXG; pfam04740 1279365007597 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1279365007598 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1279365007599 MoxR-like ATPases [General function prediction only]; Region: COG0714 1279365007600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365007601 Walker A motif; other site 1279365007602 ATP binding site [chemical binding]; other site 1279365007603 Walker B motif; other site 1279365007604 arginine finger; other site 1279365007605 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1279365007606 Protein of unknown function DUF58; Region: DUF58; pfam01882 1279365007607 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1279365007608 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365007609 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365007610 adenine deaminase; Region: ade; TIGR01178 1279365007611 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1279365007612 active site 1279365007613 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1279365007614 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1279365007615 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365007616 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1279365007617 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1279365007618 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1279365007619 tetramer interface [polypeptide binding]; other site 1279365007620 heme binding pocket [chemical binding]; other site 1279365007621 acetylornithine aminotransferase; Provisional; Region: PRK02627 1279365007622 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365007623 inhibitor-cofactor binding pocket; inhibition site 1279365007624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365007625 catalytic residue [active] 1279365007626 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365007627 active site 1279365007628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365007629 active site 1279365007630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365007631 active site 1279365007632 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1279365007633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1279365007634 active site 1279365007635 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1279365007636 Ligand binding site; other site 1279365007637 Putative Catalytic site; other site 1279365007638 DXD motif; other site 1279365007639 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1279365007640 active site 1279365007641 proline/glycine betaine transporter; Provisional; Region: PRK10642 1279365007642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007643 putative substrate translocation pore; other site 1279365007644 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 1279365007645 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1279365007646 Protein of unknown function DUF58; Region: DUF58; pfam01882 1279365007647 MoxR-like ATPases [General function prediction only]; Region: COG0714 1279365007648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365007649 Walker A motif; other site 1279365007650 ATP binding site [chemical binding]; other site 1279365007651 Walker B motif; other site 1279365007652 arginine finger; other site 1279365007653 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365007654 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1279365007655 transposase/IS protein; Provisional; Region: PRK09183 1279365007656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365007657 Walker A motif; other site 1279365007658 ATP binding site [chemical binding]; other site 1279365007659 Walker B motif; other site 1279365007660 arginine finger; other site 1279365007661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365007662 Integrase core domain; Region: rve; pfam00665 1279365007663 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1279365007664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365007665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1279365007666 active site 1279365007667 metal binding site [ion binding]; metal-binding site 1279365007668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365007669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365007671 Coenzyme A binding pocket [chemical binding]; other site 1279365007672 uridine kinase; Provisional; Region: PRK07667 1279365007673 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1279365007674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365007675 motif II; other site 1279365007676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365007677 salt bridge; other site 1279365007678 non-specific DNA binding site [nucleotide binding]; other site 1279365007679 sequence-specific DNA binding site [nucleotide binding]; other site 1279365007680 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1279365007681 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1279365007682 dimer interface [polypeptide binding]; other site 1279365007683 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1279365007684 active site 1279365007685 VanW like protein; Region: VanW; pfam04294 1279365007686 VanW like protein; Region: VanW; pfam04294 1279365007687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1279365007688 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 1279365007689 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1279365007690 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1279365007691 putative di-iron ligands [ion binding]; other site 1279365007692 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 1279365007693 putative metal binding site [ion binding]; other site 1279365007694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365007695 S-methylmethionine transporter; Provisional; Region: PRK11387 1279365007696 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1279365007697 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1279365007698 Bacterial transcriptional regulator; Region: IclR; pfam01614 1279365007699 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1279365007700 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1279365007701 putative metal binding site [ion binding]; other site 1279365007702 putative dimer interface [polypeptide binding]; other site 1279365007703 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1279365007704 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1279365007705 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1279365007706 gamma-glutamyl kinase; Provisional; Region: PRK05429 1279365007707 homotetrameric interface [polypeptide binding]; other site 1279365007708 putative phosphate binding site [ion binding]; other site 1279365007709 putative allosteric binding site; other site 1279365007710 nucleotide binding site [chemical binding]; other site 1279365007711 PUA domain; Region: PUA; pfam01472 1279365007712 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1279365007713 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1279365007714 putative catalytic cysteine [active] 1279365007715 putative transposase OrfB; Reviewed; Region: PHA02517 1279365007716 HTH-like domain; Region: HTH_21; pfam13276 1279365007717 Integrase core domain; Region: rve; pfam00665 1279365007718 Integrase core domain; Region: rve_2; pfam13333 1279365007719 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365007720 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365007721 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365007722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365007723 putative DNA binding site [nucleotide binding]; other site 1279365007724 putative Zn2+ binding site [ion binding]; other site 1279365007725 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365007726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007727 putative substrate translocation pore; other site 1279365007728 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1279365007729 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1279365007730 active site 1279365007731 NTP binding site [chemical binding]; other site 1279365007732 metal binding triad [ion binding]; metal-binding site 1279365007733 antibiotic binding site [chemical binding]; other site 1279365007734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365007735 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365007736 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365007737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365007738 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1279365007739 active site 1279365007740 metal binding site [ion binding]; metal-binding site 1279365007741 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1279365007742 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1279365007743 putative active site; other site 1279365007744 catalytic residue [active] 1279365007745 Cupin domain; Region: Cupin_2; pfam07883 1279365007746 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1279365007747 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1279365007748 putative N- and C-terminal domain interface [polypeptide binding]; other site 1279365007749 putative active site [active] 1279365007750 putative MgATP binding site [chemical binding]; other site 1279365007751 catalytic site [active] 1279365007752 metal binding site [ion binding]; metal-binding site 1279365007753 putative carbohydrate binding site [chemical binding]; other site 1279365007754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1279365007755 DNA binding residues [nucleotide binding] 1279365007756 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1279365007757 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1279365007758 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1279365007759 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1279365007760 Walker A/P-loop; other site 1279365007761 ATP binding site [chemical binding]; other site 1279365007762 Q-loop/lid; other site 1279365007763 ABC transporter signature motif; other site 1279365007764 Walker B; other site 1279365007765 D-loop; other site 1279365007766 H-loop/switch region; other site 1279365007767 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1279365007768 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1279365007769 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1279365007770 TM-ABC transporter signature motif; other site 1279365007771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1279365007772 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1279365007773 TM-ABC transporter signature motif; other site 1279365007774 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1279365007775 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1279365007776 ligand binding site [chemical binding]; other site 1279365007777 malate:quinone oxidoreductase; Validated; Region: PRK05257 1279365007778 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1279365007779 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1279365007780 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1279365007781 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365007782 Berberine and berberine like; Region: BBE; pfam08031 1279365007783 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365007784 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365007785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1279365007786 hypothetical protein; Provisional; Region: PRK06762 1279365007787 AAA domain; Region: AAA_33; pfam13671 1279365007788 YfzA-like protein; Region: YfzA; pfam14118 1279365007789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365007790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007791 Coenzyme A binding pocket [chemical binding]; other site 1279365007792 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1279365007793 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365007794 catalytic triad [active] 1279365007795 conserved cis-peptide bond; other site 1279365007796 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1279365007797 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 1279365007798 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 1279365007799 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1279365007800 Chorismate mutase type II; Region: CM_2; cl00693 1279365007801 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1279365007802 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1279365007803 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1279365007804 Tetramer interface [polypeptide binding]; other site 1279365007805 active site 1279365007806 FMN-binding site [chemical binding]; other site 1279365007807 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1279365007808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365007809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365007810 homodimer interface [polypeptide binding]; other site 1279365007811 catalytic residue [active] 1279365007812 prephenate dehydrogenase; Validated; Region: PRK06545 1279365007813 prephenate dehydrogenase; Validated; Region: PRK08507 1279365007814 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1279365007815 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1279365007816 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1279365007817 hinge; other site 1279365007818 active site 1279365007819 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1279365007820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007821 Coenzyme A binding pocket [chemical binding]; other site 1279365007822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365007823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365007824 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1279365007825 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365007826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365007827 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1279365007828 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1279365007829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365007830 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365007831 ABC transporter; Region: ABC_tran_2; pfam12848 1279365007832 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365007833 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1279365007834 Sulfatase; Region: Sulfatase; pfam00884 1279365007835 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1279365007836 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365007837 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1279365007838 NodB motif; other site 1279365007839 active site 1279365007840 catalytic site [active] 1279365007841 Zn binding site [ion binding]; other site 1279365007842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365007843 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1279365007844 active site 1279365007845 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1279365007846 active site 1279365007847 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1279365007848 active site 1279365007849 NTP binding site [chemical binding]; other site 1279365007850 metal binding triad [ion binding]; metal-binding site 1279365007851 antibiotic binding site [chemical binding]; other site 1279365007852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365007853 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365007854 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1279365007855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007856 Coenzyme A binding pocket [chemical binding]; other site 1279365007857 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1279365007858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1279365007859 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365007860 Coenzyme A binding pocket [chemical binding]; other site 1279365007861 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1279365007862 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1279365007863 hypothetical protein; Provisional; Region: PRK09620 1279365007864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1279365007865 binding surface 1279365007866 TPR motif; other site 1279365007867 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1279365007868 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1279365007869 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1279365007870 Walker A/P-loop; other site 1279365007871 ATP binding site [chemical binding]; other site 1279365007872 Q-loop/lid; other site 1279365007873 ABC transporter signature motif; other site 1279365007874 Walker B; other site 1279365007875 D-loop; other site 1279365007876 H-loop/switch region; other site 1279365007877 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1279365007878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365007879 substrate binding pocket [chemical binding]; other site 1279365007880 membrane-bound complex binding site; other site 1279365007881 hinge residues; other site 1279365007882 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1279365007883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1279365007884 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1279365007885 active site 1279365007886 dimer interface [polypeptide binding]; other site 1279365007887 non-prolyl cis peptide bond; other site 1279365007888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1279365007889 HNH endonuclease; Region: HNH_5; pfam14279 1279365007890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1279365007891 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1279365007892 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1279365007893 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 1279365007894 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1279365007895 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 1279365007896 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1279365007897 Predicted transcriptional regulators [Transcription]; Region: COG1725 1279365007898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365007899 DNA-binding site [nucleotide binding]; DNA binding site 1279365007900 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365007901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365007902 Walker A/P-loop; other site 1279365007903 ATP binding site [chemical binding]; other site 1279365007904 Q-loop/lid; other site 1279365007905 ABC transporter signature motif; other site 1279365007906 Walker B; other site 1279365007907 D-loop; other site 1279365007908 H-loop/switch region; other site 1279365007909 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 1279365007910 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1279365007911 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1279365007912 pantothenate kinase; Provisional; Region: PRK13317 1279365007913 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1279365007914 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1279365007915 aspartate aminotransferase; Provisional; Region: PRK07681 1279365007916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365007917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365007918 homodimer interface [polypeptide binding]; other site 1279365007919 catalytic residue [active] 1279365007920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007921 putative substrate translocation pore; other site 1279365007922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365007923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365007924 S-adenosylmethionine binding site [chemical binding]; other site 1279365007925 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1279365007926 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1279365007927 active site 1279365007928 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1279365007929 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1279365007930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365007932 putative substrate translocation pore; other site 1279365007933 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1279365007934 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1279365007935 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1279365007936 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1279365007937 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1279365007938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007939 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1279365007940 putative substrate translocation pore; other site 1279365007941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365007942 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1279365007943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365007944 Coenzyme A binding pocket [chemical binding]; other site 1279365007945 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1279365007946 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1279365007947 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1279365007948 EDD domain protein, DegV family; Region: DegV; TIGR00762 1279365007949 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1279365007950 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365007951 Zn binding site [ion binding]; other site 1279365007952 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1279365007953 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1279365007954 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1279365007955 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1279365007956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365007957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365007958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365007959 active site 1279365007960 phosphorylation site [posttranslational modification] 1279365007961 intermolecular recognition site; other site 1279365007962 dimerization interface [polypeptide binding]; other site 1279365007963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365007964 DNA binding site [nucleotide binding] 1279365007965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365007966 dimerization interface [polypeptide binding]; other site 1279365007967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365007968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365007969 dimer interface [polypeptide binding]; other site 1279365007970 phosphorylation site [posttranslational modification] 1279365007971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365007972 ATP binding site [chemical binding]; other site 1279365007973 Mg2+ binding site [ion binding]; other site 1279365007974 G-X-G motif; other site 1279365007975 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1279365007976 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1279365007977 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1279365007978 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1279365007979 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365007980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365007981 S-adenosylmethionine binding site [chemical binding]; other site 1279365007982 AAA domain; Region: AAA_17; pfam13207 1279365007983 AAA domain; Region: AAA_18; pfam13238 1279365007984 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1279365007985 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1279365007986 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1279365007987 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1279365007988 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1279365007989 conserved cys residue [active] 1279365007990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365007991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365007992 active site 1279365007993 catalytic tetrad [active] 1279365007994 Septum formation initiator; Region: DivIC; cl17659 1279365007995 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 1279365007996 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1279365007997 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1279365007998 active site 1279365007999 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1279365008000 NlpC/P60 family; Region: NLPC_P60; pfam00877 1279365008001 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365008002 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365008003 peptide binding site [polypeptide binding]; other site 1279365008004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365008005 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365008006 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1279365008007 DltD N-terminal region; Region: DltD_N; pfam04915 1279365008008 DltD central region; Region: DltD_M; pfam04918 1279365008009 DltD C-terminal region; Region: DltD_C; pfam04914 1279365008010 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365008011 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365008012 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1279365008013 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1279365008014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1279365008015 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1279365008016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1279365008017 catalytic loop [active] 1279365008018 iron binding site [ion binding]; other site 1279365008019 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1279365008020 PAS domain; Region: PAS_10; pfam13596 1279365008021 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1279365008022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365008023 Walker A motif; other site 1279365008024 ATP binding site [chemical binding]; other site 1279365008025 Walker B motif; other site 1279365008026 arginine finger; other site 1279365008027 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1279365008028 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1279365008029 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1279365008030 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1279365008031 Proline racemase; Region: Pro_racemase; pfam05544 1279365008032 Proline racemase; Region: Pro_racemase; pfam05544 1279365008033 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1279365008034 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1279365008035 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1279365008036 inhibitor site; inhibition site 1279365008037 active site 1279365008038 dimer interface [polypeptide binding]; other site 1279365008039 catalytic residue [active] 1279365008040 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1279365008041 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1279365008042 NAD(P) binding site [chemical binding]; other site 1279365008043 catalytic residues [active] 1279365008044 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365008045 amino acid carrier protein; Region: agcS; TIGR00835 1279365008046 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1279365008047 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1279365008048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365008049 Zn2+ binding site [ion binding]; other site 1279365008050 Mg2+ binding site [ion binding]; other site 1279365008051 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365008052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008053 Coenzyme A binding pocket [chemical binding]; other site 1279365008054 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1279365008055 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1279365008056 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1279365008057 DHHA2 domain; Region: DHHA2; pfam02833 1279365008058 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 1279365008059 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1279365008060 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1279365008061 active site 1279365008062 metal binding site [ion binding]; metal-binding site 1279365008063 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1279365008064 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1279365008065 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1279365008066 active site 1279365008067 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 1279365008068 putative transposase OrfB; Reviewed; Region: PHA02517 1279365008069 HTH-like domain; Region: HTH_21; pfam13276 1279365008070 Integrase core domain; Region: rve; pfam00665 1279365008071 Integrase core domain; Region: rve_2; pfam13333 1279365008072 Transposase; Region: HTH_Tnp_1; cl17663 1279365008073 putative transposase OrfB; Reviewed; Region: PHA02517 1279365008074 HTH-like domain; Region: HTH_21; pfam13276 1279365008075 Integrase core domain; Region: rve; pfam00665 1279365008076 Integrase core domain; Region: rve_2; pfam13333 1279365008077 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1279365008078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365008079 ATP binding site [chemical binding]; other site 1279365008080 putative Mg++ binding site [ion binding]; other site 1279365008081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365008082 nucleotide binding region [chemical binding]; other site 1279365008083 ATP-binding site [chemical binding]; other site 1279365008084 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1279365008085 HRDC domain; Region: HRDC; pfam00570 1279365008086 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1279365008087 putative active site pocket [active] 1279365008088 dimerization interface [polypeptide binding]; other site 1279365008089 putative catalytic residue [active] 1279365008090 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1279365008091 Part of AAA domain; Region: AAA_19; pfam13245 1279365008092 Family description; Region: UvrD_C_2; pfam13538 1279365008093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008094 Coenzyme A binding pocket [chemical binding]; other site 1279365008095 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365008096 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365008097 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1279365008098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008099 Coenzyme A binding pocket [chemical binding]; other site 1279365008100 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1279365008101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008102 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365008103 Coenzyme A binding pocket [chemical binding]; other site 1279365008104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008105 Coenzyme A binding pocket [chemical binding]; other site 1279365008106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1279365008107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365008108 S-adenosylmethionine binding site [chemical binding]; other site 1279365008109 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1279365008110 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365008111 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365008112 active site 1279365008113 ATP binding site [chemical binding]; other site 1279365008114 topology modulation protein; Reviewed; Region: PRK08118 1279365008115 AAA domain; Region: AAA_17; pfam13207 1279365008116 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1279365008117 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1279365008118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1279365008119 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1279365008120 TDP-binding site; other site 1279365008121 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1279365008122 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365008123 Interdomain contacts; other site 1279365008124 Cytokine receptor motif; other site 1279365008125 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365008126 Interdomain contacts; other site 1279365008127 Cytokine receptor motif; other site 1279365008128 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1279365008129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008130 Coenzyme A binding pocket [chemical binding]; other site 1279365008131 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1279365008132 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365008133 active site 1279365008134 dimer interface [polypeptide binding]; other site 1279365008135 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1279365008136 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1279365008137 catalytic loop [active] 1279365008138 iron binding site [ion binding]; other site 1279365008139 RNA polymerase factor sigma-70; Validated; Region: PRK06704 1279365008140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365008141 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1279365008142 DNA binding residues [nucleotide binding] 1279365008143 Clp protease; Region: CLP_protease; pfam00574 1279365008144 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1279365008145 oligomer interface [polypeptide binding]; other site 1279365008146 active site residues [active] 1279365008147 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1279365008148 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1279365008149 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1279365008150 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1279365008151 Walker A/P-loop; other site 1279365008152 ATP binding site [chemical binding]; other site 1279365008153 Q-loop/lid; other site 1279365008154 ABC transporter signature motif; other site 1279365008155 Walker B; other site 1279365008156 D-loop; other site 1279365008157 H-loop/switch region; other site 1279365008158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1279365008159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365008160 dimer interface [polypeptide binding]; other site 1279365008161 conserved gate region; other site 1279365008162 putative PBP binding loops; other site 1279365008163 ABC-ATPase subunit interface; other site 1279365008164 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1279365008165 nucleotide binding site/active site [active] 1279365008166 HIT family signature motif; other site 1279365008167 catalytic residue [active] 1279365008168 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1279365008169 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1279365008170 nudix motif; other site 1279365008171 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1279365008172 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1279365008173 short chain dehydrogenase; Provisional; Region: PRK06914 1279365008174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365008175 NAD(P) binding site [chemical binding]; other site 1279365008176 active site 1279365008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365008178 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008179 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1279365008181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365008182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008183 putative substrate translocation pore; other site 1279365008184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365008185 DinB superfamily; Region: DinB_2; pfam12867 1279365008186 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1279365008187 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1279365008188 tetramer interface [polypeptide binding]; other site 1279365008189 TPP-binding site [chemical binding]; other site 1279365008190 heterodimer interface [polypeptide binding]; other site 1279365008191 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1279365008192 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1279365008193 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1279365008194 alpha subunit interface [polypeptide binding]; other site 1279365008195 TPP binding site [chemical binding]; other site 1279365008196 heterodimer interface [polypeptide binding]; other site 1279365008197 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365008198 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1279365008199 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1279365008200 E3 interaction surface; other site 1279365008201 lipoyl attachment site [posttranslational modification]; other site 1279365008202 e3 binding domain; Region: E3_binding; pfam02817 1279365008203 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1279365008204 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1279365008205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365008206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365008207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1279365008208 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 1279365008209 Rrf2 family protein; Region: rrf2_super; TIGR00738 1279365008210 Transcriptional regulator; Region: Rrf2; pfam02082 1279365008211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365008212 S-adenosylmethionine binding site [chemical binding]; other site 1279365008213 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1279365008214 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1279365008215 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1279365008216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365008217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008218 Coenzyme A binding pocket [chemical binding]; other site 1279365008219 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1279365008220 GAF domain; Region: GAF; pfam01590 1279365008221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365008222 Walker A motif; other site 1279365008223 ATP binding site [chemical binding]; other site 1279365008224 Walker B motif; other site 1279365008225 arginine finger; other site 1279365008226 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1279365008227 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 1279365008228 Major royal jelly protein; Region: MRJP; pfam03022 1279365008229 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1279365008230 nudix motif; other site 1279365008231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365008232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365008233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1279365008234 kynureninase; Region: kynureninase; TIGR01814 1279365008235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365008236 catalytic residue [active] 1279365008237 Putative cyclase; Region: Cyclase; cl00814 1279365008238 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1279365008239 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365008240 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365008241 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1279365008242 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1279365008243 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1279365008244 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1279365008245 germination protein YpeB; Region: spore_YpeB; TIGR02889 1279365008246 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1279365008247 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1279365008248 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365008249 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1279365008250 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1279365008251 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1279365008252 Mg binding site [ion binding]; other site 1279365008253 nucleotide binding site [chemical binding]; other site 1279365008254 putative protofilament interface [polypeptide binding]; other site 1279365008255 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365008256 TAP-like protein; Region: Abhydrolase_4; pfam08386 1279365008257 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365008258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365008259 DNA-binding site [nucleotide binding]; DNA binding site 1279365008260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365008261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365008262 homodimer interface [polypeptide binding]; other site 1279365008263 catalytic residue [active] 1279365008264 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1279365008265 EamA-like transporter family; Region: EamA; pfam00892 1279365008266 EamA-like transporter family; Region: EamA; pfam00892 1279365008267 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 1279365008268 SecY translocase; Region: SecY; pfam00344 1279365008269 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1279365008270 DinB superfamily; Region: DinB_2; pfam12867 1279365008271 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 1279365008272 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1279365008273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365008274 active site 1279365008275 metal binding site [ion binding]; metal-binding site 1279365008276 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1279365008277 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365008278 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365008279 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1279365008280 active site 1279365008281 Zn binding site [ion binding]; other site 1279365008282 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1279365008283 carbohydrate binding site [chemical binding]; other site 1279365008284 pullulanase, type I; Region: pulA_typeI; TIGR02104 1279365008285 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1279365008286 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1279365008287 Ca binding site [ion binding]; other site 1279365008288 active site 1279365008289 catalytic site [active] 1279365008290 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1279365008291 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1279365008292 putative FMN binding site [chemical binding]; other site 1279365008293 NADPH bind site [chemical binding]; other site 1279365008294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1279365008295 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1279365008296 acyl-activating enzyme (AAE) consensus motif; other site 1279365008297 AMP binding site [chemical binding]; other site 1279365008298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365008299 Condensation domain; Region: Condensation; pfam00668 1279365008300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365008301 Integrase core domain; Region: rve; pfam00665 1279365008302 transposase/IS protein; Provisional; Region: PRK09183 1279365008303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365008304 Walker A motif; other site 1279365008305 ATP binding site [chemical binding]; other site 1279365008306 Walker B motif; other site 1279365008307 arginine finger; other site 1279365008308 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1279365008309 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1279365008310 catalytic residues [active] 1279365008311 catalytic nucleophile [active] 1279365008312 Presynaptic Site I dimer interface [polypeptide binding]; other site 1279365008313 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1279365008314 Synaptic Flat tetramer interface [polypeptide binding]; other site 1279365008315 Synaptic Site I dimer interface [polypeptide binding]; other site 1279365008316 DNA binding site [nucleotide binding] 1279365008317 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1279365008318 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1279365008319 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1279365008320 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1279365008321 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1279365008322 acyl-activating enzyme (AAE) consensus motif; other site 1279365008323 AMP binding site [chemical binding]; other site 1279365008324 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1279365008325 peptide synthase; Provisional; Region: PRK12467 1279365008326 tyrosine decarboxylase; Region: PLN02880 1279365008327 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1279365008328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365008329 catalytic residue [active] 1279365008330 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1279365008331 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1279365008332 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1279365008333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365008334 FtsX-like permease family; Region: FtsX; pfam02687 1279365008335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365008336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365008337 Walker A/P-loop; other site 1279365008338 ATP binding site [chemical binding]; other site 1279365008339 Q-loop/lid; other site 1279365008340 ABC transporter signature motif; other site 1279365008341 Walker B; other site 1279365008342 D-loop; other site 1279365008343 H-loop/switch region; other site 1279365008344 L-lactate permease; Region: Lactate_perm; cl00701 1279365008345 DinB superfamily; Region: DinB_2; pfam12867 1279365008346 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1279365008347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365008348 dimerization interface [polypeptide binding]; other site 1279365008349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365008350 dimer interface [polypeptide binding]; other site 1279365008351 phosphorylation site [posttranslational modification] 1279365008352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365008353 ATP binding site [chemical binding]; other site 1279365008354 Mg2+ binding site [ion binding]; other site 1279365008355 G-X-G motif; other site 1279365008356 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1279365008357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365008358 active site 1279365008359 phosphorylation site [posttranslational modification] 1279365008360 intermolecular recognition site; other site 1279365008361 dimerization interface [polypeptide binding]; other site 1279365008362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365008363 DNA binding site [nucleotide binding] 1279365008364 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1279365008365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365008366 motif II; other site 1279365008367 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1279365008368 MepB protein; Region: MepB; pfam08877 1279365008369 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1279365008370 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1279365008371 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1279365008372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365008373 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1279365008374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008375 Coenzyme A binding pocket [chemical binding]; other site 1279365008376 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1279365008377 GIY-YIG motif/motif A; other site 1279365008378 active site 1279365008379 catalytic site [active] 1279365008380 putative DNA binding site [nucleotide binding]; other site 1279365008381 metal binding site [ion binding]; metal-binding site 1279365008382 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1279365008383 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1279365008384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365008385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365008386 metal-dependent hydrolase; Provisional; Region: PRK13291 1279365008387 DinB superfamily; Region: DinB_2; pfam12867 1279365008388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008389 Coenzyme A binding pocket [chemical binding]; other site 1279365008390 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1279365008391 pentamer interface [polypeptide binding]; other site 1279365008392 dodecaamer interface [polypeptide binding]; other site 1279365008393 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1279365008394 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1279365008395 active site 1279365008396 nucleophile elbow; other site 1279365008397 YxiJ-like protein; Region: YxiJ; pfam14176 1279365008398 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1279365008399 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1279365008400 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1279365008401 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1279365008402 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1279365008403 homotrimer interaction site [polypeptide binding]; other site 1279365008404 putative active site [active] 1279365008405 translation initiation factor IF-2; Provisional; Region: PRK14845 1279365008406 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1279365008407 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1279365008408 DNA polymerase III subunit beta; Validated; Region: PRK06673 1279365008409 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1279365008410 putative DNA binding surface [nucleotide binding]; other site 1279365008411 dimer interface [polypeptide binding]; other site 1279365008412 beta-clamp/clamp loader binding surface; other site 1279365008413 beta-clamp/translesion DNA polymerase binding surface; other site 1279365008414 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1279365008415 nudix motif; other site 1279365008416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365008417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008418 Coenzyme A binding pocket [chemical binding]; other site 1279365008419 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1279365008420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008421 putative substrate translocation pore; other site 1279365008422 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365008423 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365008424 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 1279365008425 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1279365008426 nudix motif; other site 1279365008427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1279365008428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008429 Coenzyme A binding pocket [chemical binding]; other site 1279365008430 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1279365008431 active site 1279365008432 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1279365008433 EamA-like transporter family; Region: EamA; pfam00892 1279365008434 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365008435 EamA-like transporter family; Region: EamA; pfam00892 1279365008436 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365008437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365008438 DNA-binding site [nucleotide binding]; DNA binding site 1279365008439 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365008440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365008441 homodimer interface [polypeptide binding]; other site 1279365008442 catalytic residue [active] 1279365008443 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 1279365008444 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1279365008445 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1279365008446 active site 1279365008447 catalytic site [active] 1279365008448 metal binding site [ion binding]; metal-binding site 1279365008449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008450 Coenzyme A binding pocket [chemical binding]; other site 1279365008451 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365008452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365008453 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365008454 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365008455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008457 putative substrate translocation pore; other site 1279365008458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365008459 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1279365008460 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365008461 DNA binding residues [nucleotide binding] 1279365008462 Trm112p-like protein; Region: Trm112p; pfam03966 1279365008463 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1279365008464 EDD domain protein, DegV family; Region: DegV; TIGR00762 1279365008465 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1279365008466 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 1279365008467 VanZ like family; Region: VanZ; pfam04892 1279365008468 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365008469 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365008470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008471 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365008472 putative substrate translocation pore; other site 1279365008473 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365008474 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008475 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365008476 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1279365008477 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1279365008478 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1279365008479 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1279365008480 active site 1279365008481 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365008482 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1279365008483 NAD(P) binding site [chemical binding]; other site 1279365008484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365008485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365008486 dimerization interface [polypeptide binding]; other site 1279365008487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365008488 dimer interface [polypeptide binding]; other site 1279365008489 phosphorylation site [posttranslational modification] 1279365008490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365008491 ATP binding site [chemical binding]; other site 1279365008492 Mg2+ binding site [ion binding]; other site 1279365008493 G-X-G motif; other site 1279365008494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365008495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365008496 active site 1279365008497 phosphorylation site [posttranslational modification] 1279365008498 intermolecular recognition site; other site 1279365008499 dimerization interface [polypeptide binding]; other site 1279365008500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365008501 DNA binding site [nucleotide binding] 1279365008502 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1279365008503 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1279365008504 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1279365008505 active site 1279365008506 ATP binding site [chemical binding]; other site 1279365008507 substrate binding site [chemical binding]; other site 1279365008508 activation loop (A-loop); other site 1279365008509 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365008510 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1279365008511 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1279365008512 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1279365008513 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365008514 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365008515 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1279365008516 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365008517 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365008518 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365008519 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1279365008520 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1279365008521 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365008522 DNA binding site [nucleotide binding] 1279365008523 active site 1279365008524 Int/Topo IB signature motif; other site 1279365008525 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1279365008526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365008527 dimer interface [polypeptide binding]; other site 1279365008528 phosphorylation site [posttranslational modification] 1279365008529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365008530 ATP binding site [chemical binding]; other site 1279365008531 Mg2+ binding site [ion binding]; other site 1279365008532 G-X-G motif; other site 1279365008533 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1279365008534 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1279365008535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1279365008536 Walker A/P-loop; other site 1279365008537 ATP binding site [chemical binding]; other site 1279365008538 Q-loop/lid; other site 1279365008539 ABC transporter signature motif; other site 1279365008540 Walker B; other site 1279365008541 D-loop; other site 1279365008542 H-loop/switch region; other site 1279365008543 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1279365008544 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1279365008545 Walker A/P-loop; other site 1279365008546 ATP binding site [chemical binding]; other site 1279365008547 Q-loop/lid; other site 1279365008548 ABC transporter signature motif; other site 1279365008549 Walker B; other site 1279365008550 D-loop; other site 1279365008551 H-loop/switch region; other site 1279365008552 hypothetical protein; Provisional; Region: PRK13661 1279365008553 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1279365008554 aspartate racemase; Region: asp_race; TIGR00035 1279365008555 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1279365008556 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1279365008557 active site 1279365008558 TDP-binding site; other site 1279365008559 acceptor substrate-binding pocket; other site 1279365008560 homodimer interface [polypeptide binding]; other site 1279365008561 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1279365008562 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365008563 Catalytic site [active] 1279365008564 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365008565 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008566 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008567 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365008568 PAS domain S-box; Region: sensory_box; TIGR00229 1279365008569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365008570 putative active site [active] 1279365008571 heme pocket [chemical binding]; other site 1279365008572 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1279365008573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1279365008574 putative active site [active] 1279365008575 heme pocket [chemical binding]; other site 1279365008576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365008577 dimer interface [polypeptide binding]; other site 1279365008578 phosphorylation site [posttranslational modification] 1279365008579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365008580 ATP binding site [chemical binding]; other site 1279365008581 Mg2+ binding site [ion binding]; other site 1279365008582 G-X-G motif; other site 1279365008583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365008584 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365008585 active site 1279365008586 motif I; other site 1279365008587 motif II; other site 1279365008588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365008589 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1279365008590 Cytochrome P450; Region: p450; cl12078 1279365008591 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1279365008592 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365008593 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365008594 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1279365008595 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1279365008596 trimer interface [polypeptide binding]; other site 1279365008597 active site 1279365008598 substrate binding site [chemical binding]; other site 1279365008599 CoA binding site [chemical binding]; other site 1279365008600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008601 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365008602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008603 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1279365008604 Cytochrome P450; Region: p450; cl12078 1279365008605 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1279365008606 Protein of unknown function; Region: DUF3658; pfam12395 1279365008607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365008608 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365008609 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365008610 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1279365008611 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 1279365008612 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 1279365008613 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 1279365008614 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 1279365008615 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 1279365008616 Putative transcription activator [Transcription]; Region: TenA; COG0819 1279365008617 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1279365008618 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1279365008619 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1279365008620 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365008621 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365008622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365008623 DNA-binding site [nucleotide binding]; DNA binding site 1279365008624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365008625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365008626 homodimer interface [polypeptide binding]; other site 1279365008627 catalytic residue [active] 1279365008628 homoserine dehydrogenase; Validated; Region: PRK06813 1279365008629 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1279365008630 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1279365008631 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 1279365008632 hypothetical protein; Provisional; Region: PRK06760 1279365008633 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365008634 FtsX-like permease family; Region: FtsX; pfam02687 1279365008635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365008636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365008637 Walker A/P-loop; other site 1279365008638 ATP binding site [chemical binding]; other site 1279365008639 Q-loop/lid; other site 1279365008640 ABC transporter signature motif; other site 1279365008641 Walker B; other site 1279365008642 D-loop; other site 1279365008643 H-loop/switch region; other site 1279365008644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365008645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365008646 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365008647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365008648 ABC transporter; Region: ABC_tran_2; pfam12848 1279365008649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365008650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365008651 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1279365008652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365008653 ATP binding site [chemical binding]; other site 1279365008654 Mg2+ binding site [ion binding]; other site 1279365008655 G-X-G motif; other site 1279365008656 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365008657 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365008658 putative active site [active] 1279365008659 putative NTP binding site [chemical binding]; other site 1279365008660 putative nucleic acid binding site [nucleotide binding]; other site 1279365008661 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1279365008662 active site 1279365008663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365008664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365008665 active site 1279365008666 phosphorylation site [posttranslational modification] 1279365008667 intermolecular recognition site; other site 1279365008668 dimerization interface [polypeptide binding]; other site 1279365008669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365008670 DNA binding site [nucleotide binding] 1279365008671 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1279365008672 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1279365008673 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1279365008674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1279365008675 active site 1279365008676 KMSKS motif; other site 1279365008677 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1279365008678 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1279365008679 active site 1279365008680 HIGH motif; other site 1279365008681 nucleotide binding site [chemical binding]; other site 1279365008682 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1279365008683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365008684 S-adenosylmethionine binding site [chemical binding]; other site 1279365008685 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1279365008686 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1279365008687 conserved cys residue [active] 1279365008688 Predicted membrane protein [Function unknown]; Region: COG2323 1279365008689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365008690 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1279365008691 NAD(P) binding site [chemical binding]; other site 1279365008692 active site 1279365008693 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1279365008694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008695 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008696 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1279365008697 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 1279365008698 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1279365008699 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365008700 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365008701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365008702 DNA-binding site [nucleotide binding]; DNA binding site 1279365008703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365008704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365008705 homodimer interface [polypeptide binding]; other site 1279365008706 catalytic residue [active] 1279365008707 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 1279365008708 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 1279365008709 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1279365008710 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1279365008711 active site 1279365008712 Zn binding site [ion binding]; other site 1279365008713 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1279365008714 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1279365008715 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365008716 Walker A/P-loop; other site 1279365008717 ATP binding site [chemical binding]; other site 1279365008718 Q-loop/lid; other site 1279365008719 ABC transporter signature motif; other site 1279365008720 Walker B; other site 1279365008721 D-loop; other site 1279365008722 H-loop/switch region; other site 1279365008723 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365008724 active site 1279365008725 ATP binding site [chemical binding]; other site 1279365008726 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365008727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365008728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365008729 dimerization interface [polypeptide binding]; other site 1279365008730 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1279365008731 active site 1 [active] 1279365008732 dimer interface [polypeptide binding]; other site 1279365008733 hexamer interface [polypeptide binding]; other site 1279365008734 active site 2 [active] 1279365008735 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1279365008736 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365008737 active site 1279365008738 short chain dehydrogenase; Provisional; Region: PRK07041 1279365008739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365008740 NAD(P) binding site [chemical binding]; other site 1279365008741 active site 1279365008742 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1279365008743 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365008744 DNA binding residues [nucleotide binding] 1279365008745 drug binding residues [chemical binding]; other site 1279365008746 dimer interface [polypeptide binding]; other site 1279365008747 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1279365008748 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1279365008749 putative hydrophobic ligand binding site [chemical binding]; other site 1279365008750 transposase/IS protein; Provisional; Region: PRK09183 1279365008751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365008752 Walker A motif; other site 1279365008753 ATP binding site [chemical binding]; other site 1279365008754 Walker B motif; other site 1279365008755 arginine finger; other site 1279365008756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365008757 Integrase core domain; Region: rve; pfam00665 1279365008758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1279365008759 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1279365008760 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1279365008761 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365008762 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365008763 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365008764 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365008765 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1279365008766 active site 1279365008767 catalytic site [active] 1279365008768 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365008769 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365008770 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365008771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1279365008772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365008773 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365008774 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365008775 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1279365008776 active site 1279365008777 Zn binding site [ion binding]; other site 1279365008778 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1279365008779 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1279365008780 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1279365008781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008782 Coenzyme A binding pocket [chemical binding]; other site 1279365008783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1279365008784 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 1279365008785 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365008786 Zn2+ binding site [ion binding]; other site 1279365008787 Mg2+ binding site [ion binding]; other site 1279365008788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365008789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365008790 active site 1279365008791 phosphorylation site [posttranslational modification] 1279365008792 intermolecular recognition site; other site 1279365008793 dimerization interface [polypeptide binding]; other site 1279365008794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365008795 DNA binding site [nucleotide binding] 1279365008796 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365008799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365008800 dimer interface [polypeptide binding]; other site 1279365008801 phosphorylation site [posttranslational modification] 1279365008802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365008803 ATP binding site [chemical binding]; other site 1279365008804 Mg2+ binding site [ion binding]; other site 1279365008805 G-X-G motif; other site 1279365008806 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1279365008807 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365008808 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 1279365008809 hypothetical protein; Provisional; Region: PRK08233 1279365008810 AAA domain; Region: AAA_18; pfam13238 1279365008811 active site 1279365008812 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365008813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365008814 Coenzyme A binding pocket [chemical binding]; other site 1279365008815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365008816 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365008817 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365008818 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1279365008819 Septum formation initiator; Region: DivIC; pfam04977 1279365008820 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1279365008821 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1279365008822 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 1279365008823 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 1279365008824 acyl-activating enzyme (AAE) consensus motif; other site 1279365008825 putative AMP binding site [chemical binding]; other site 1279365008826 putative active site [active] 1279365008827 putative CoA binding site [chemical binding]; other site 1279365008828 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1279365008829 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1279365008830 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1279365008831 enoyl-CoA hydratase; Provisional; Region: PRK07657 1279365008832 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1279365008833 substrate binding site [chemical binding]; other site 1279365008834 oxyanion hole (OAH) forming residues; other site 1279365008835 trimer interface [polypeptide binding]; other site 1279365008836 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1279365008837 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1279365008838 active site 1279365008839 catalytic residues [active] 1279365008840 metal binding site [ion binding]; metal-binding site 1279365008841 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1279365008842 carboxyltransferase (CT) interaction site; other site 1279365008843 biotinylation site [posttranslational modification]; other site 1279365008844 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1279365008845 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1279365008846 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1279365008847 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1279365008848 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1279365008849 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1279365008850 FAD binding site [chemical binding]; other site 1279365008851 homotetramer interface [polypeptide binding]; other site 1279365008852 substrate binding pocket [chemical binding]; other site 1279365008853 catalytic base [active] 1279365008854 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1279365008855 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1279365008856 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1279365008857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365008858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365008859 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1279365008860 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1279365008861 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365008862 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1279365008863 Walker A/P-loop; other site 1279365008864 ATP binding site [chemical binding]; other site 1279365008865 Q-loop/lid; other site 1279365008866 ABC transporter signature motif; other site 1279365008867 Walker B; other site 1279365008868 D-loop; other site 1279365008869 H-loop/switch region; other site 1279365008870 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365008871 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365008872 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365008873 beta-lactamase TEM; Provisional; Region: PRK15442 1279365008874 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1279365008875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1279365008876 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365008877 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008878 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365008880 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1279365008881 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365008883 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1279365008884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365008885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365008886 DNA binding residues [nucleotide binding] 1279365008887 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1279365008888 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365008889 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1279365008890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365008891 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1279365008892 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1279365008893 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1279365008894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1279365008895 Divalent cation transporter; Region: MgtE; pfam01769 1279365008896 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1279365008897 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1279365008898 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1279365008899 iron-sulfur cluster [ion binding]; other site 1279365008900 [2Fe-2S] cluster binding site [ion binding]; other site 1279365008901 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1279365008902 hydrophobic ligand binding site; other site 1279365008903 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365008904 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1279365008905 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1279365008906 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1279365008907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365008908 catalytic residue [active] 1279365008909 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1279365008910 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1279365008911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365008912 FeS/SAM binding site; other site 1279365008913 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1279365008914 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365008915 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365008916 putative active site [active] 1279365008917 putative NTP binding site [chemical binding]; other site 1279365008918 putative nucleic acid binding site [nucleotide binding]; other site 1279365008919 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365008920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365008921 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1279365008922 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1279365008923 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1279365008924 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1279365008925 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1279365008926 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1279365008927 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1279365008928 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1279365008929 active site 1279365008930 nucleophile elbow; other site 1279365008931 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1279365008932 PA/protease or protease-like domain interface [polypeptide binding]; other site 1279365008933 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1279365008934 active site 1279365008935 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1279365008936 dimer interface [polypeptide binding]; other site 1279365008937 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1279365008938 Ligand Binding Site [chemical binding]; other site 1279365008939 Molecular Tunnel; other site 1279365008940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365008941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365008942 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365008943 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1279365008944 NodB motif; other site 1279365008945 active site 1279365008946 catalytic site [active] 1279365008947 Zn binding site [ion binding]; other site 1279365008948 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1279365008949 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1279365008950 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1279365008951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365008952 non-specific DNA binding site [nucleotide binding]; other site 1279365008953 salt bridge; other site 1279365008954 sequence-specific DNA binding site [nucleotide binding]; other site 1279365008955 Cupin domain; Region: Cupin_2; pfam07883 1279365008956 S-layer homology domain; Region: SLH; pfam00395 1279365008957 S-layer homology domain; Region: SLH; pfam00395 1279365008958 S-layer homology domain; Region: SLH; pfam00395 1279365008959 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1279365008960 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1279365008961 Haemolysin XhlA; Region: XhlA; pfam10779 1279365008962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365008963 Integrase core domain; Region: rve; pfam00665 1279365008964 transposase/IS protein; Provisional; Region: PRK09183 1279365008965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365008966 Walker A motif; other site 1279365008967 ATP binding site [chemical binding]; other site 1279365008968 Walker B motif; other site 1279365008969 arginine finger; other site 1279365008970 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 1279365008971 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1279365008972 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1279365008973 active site 1279365008974 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1279365008975 Syd protein (SUKH-2); Region: Syd; pfam07348 1279365008976 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1279365008977 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1279365008978 GAD-like domain; Region: GAD-like; pfam08887 1279365008979 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1279365008980 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1279365008981 Active_site [active] 1279365008982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1279365008983 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 1279365008984 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1279365008985 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1279365008986 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1279365008987 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1279365008988 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1279365008989 putative active site [active] 1279365008990 putative metal binding site [ion binding]; other site 1279365008991 NETI protein; Region: NETI; pfam14044 1279365008992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365008993 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365008994 putative substrate translocation pore; other site 1279365008995 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365008996 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365008997 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365008998 MarR family; Region: MarR_2; pfam12802 1279365008999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365009000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365009001 putative substrate translocation pore; other site 1279365009002 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365009003 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365009004 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1279365009005 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1279365009006 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1279365009007 SWIM zinc finger; Region: SWIM; pfam04434 1279365009008 YwiC-like protein; Region: YwiC; pfam14256 1279365009009 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1279365009010 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1279365009011 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1279365009012 Walker A/P-loop; other site 1279365009013 ATP binding site [chemical binding]; other site 1279365009014 Q-loop/lid; other site 1279365009015 ABC transporter signature motif; other site 1279365009016 Walker B; other site 1279365009017 D-loop; other site 1279365009018 H-loop/switch region; other site 1279365009019 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1279365009020 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 1279365009021 Walker A/P-loop; other site 1279365009022 ATP binding site [chemical binding]; other site 1279365009023 Q-loop/lid; other site 1279365009024 ABC transporter signature motif; other site 1279365009025 Walker B; other site 1279365009026 D-loop; other site 1279365009027 H-loop/switch region; other site 1279365009028 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1279365009029 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1279365009030 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1279365009031 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1279365009032 Predicted membrane protein [Function unknown]; Region: COG1288 1279365009033 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1279365009034 putative deacylase active site [active] 1279365009035 histidyl-tRNA synthetase; Provisional; Region: PRK12420 1279365009036 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1279365009037 dimer interface [polypeptide binding]; other site 1279365009038 motif 1; other site 1279365009039 active site 1279365009040 motif 2; other site 1279365009041 motif 3; other site 1279365009042 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1279365009043 anticodon binding site; other site 1279365009044 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365009045 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1279365009046 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1279365009047 dimer interface [polypeptide binding]; other site 1279365009048 FMN binding site [chemical binding]; other site 1279365009049 pyruvate kinase; Validated; Region: PRK06739 1279365009050 active site 1279365009051 domain interfaces; other site 1279365009052 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1279365009053 classical (c) SDRs; Region: SDR_c; cd05233 1279365009054 NAD(P) binding site [chemical binding]; other site 1279365009055 active site 1279365009056 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1279365009057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365009058 Walker A/P-loop; other site 1279365009059 ATP binding site [chemical binding]; other site 1279365009060 Q-loop/lid; other site 1279365009061 ABC transporter signature motif; other site 1279365009062 Walker B; other site 1279365009063 D-loop; other site 1279365009064 H-loop/switch region; other site 1279365009065 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 1279365009066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365009067 non-specific DNA binding site [nucleotide binding]; other site 1279365009068 salt bridge; other site 1279365009069 sequence-specific DNA binding site [nucleotide binding]; other site 1279365009070 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1279365009071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365009072 motif II; other site 1279365009073 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365009074 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365009075 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1279365009076 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1279365009077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009078 Coenzyme A binding pocket [chemical binding]; other site 1279365009079 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1279365009080 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1279365009081 nudix motif; other site 1279365009082 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1279365009083 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1279365009084 active site 1279365009085 HIGH motif; other site 1279365009086 dimer interface [polypeptide binding]; other site 1279365009087 KMSKS motif; other site 1279365009088 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 1279365009089 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1279365009090 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1279365009091 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1279365009092 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1279365009093 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1279365009094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009095 Coenzyme A binding pocket [chemical binding]; other site 1279365009096 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365009097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365009098 S-adenosylmethionine binding site [chemical binding]; other site 1279365009099 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1279365009100 CGNR zinc finger; Region: zf-CGNR; pfam11706 1279365009101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365009102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365009103 putative substrate translocation pore; other site 1279365009104 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365009105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365009106 TPR motif; other site 1279365009107 binding surface 1279365009108 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365009109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365009110 binding surface 1279365009111 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365009112 TPR motif; other site 1279365009113 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 1279365009114 hypothetical protein; Provisional; Region: PRK04164 1279365009115 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365009116 ATP synthase I chain; Region: ATP_synt_I; cl09170 1279365009117 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1279365009118 Domain of unknown function DUF21; Region: DUF21; pfam01595 1279365009119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1279365009120 Transporter associated domain; Region: CorC_HlyC; smart01091 1279365009121 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1279365009122 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1279365009123 DNA binding residues [nucleotide binding] 1279365009124 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1279365009125 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1279365009126 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1279365009127 substrate binding site; other site 1279365009128 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1279365009129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365009130 NAD(P) binding site [chemical binding]; other site 1279365009131 active site 1279365009132 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1279365009133 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1279365009134 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1279365009135 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1279365009136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365009137 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1279365009138 NAD(P) binding site [chemical binding]; other site 1279365009139 active site 1279365009140 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1279365009141 Variant SH3 domain; Region: SH3_2; pfam07653 1279365009142 peptide ligand binding site [polypeptide binding]; other site 1279365009143 Src Homology 3 domain superfamily; Region: SH3; cl17036 1279365009144 peptide ligand binding site [polypeptide binding]; other site 1279365009145 EamA-like transporter family; Region: EamA; pfam00892 1279365009146 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365009147 EamA-like transporter family; Region: EamA; pfam00892 1279365009148 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1279365009149 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1279365009150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1279365009151 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1279365009152 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1279365009153 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1279365009154 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1279365009155 N- and C-terminal domain interface [polypeptide binding]; other site 1279365009156 active site 1279365009157 catalytic site [active] 1279365009158 metal binding site [ion binding]; metal-binding site 1279365009159 carbohydrate binding site [chemical binding]; other site 1279365009160 ATP binding site [chemical binding]; other site 1279365009161 GntP family permease; Region: GntP_permease; pfam02447 1279365009162 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1279365009163 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1279365009164 active site 1279365009165 intersubunit interactions; other site 1279365009166 catalytic residue [active] 1279365009167 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1279365009168 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1279365009169 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1279365009170 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1279365009171 TPP-binding site [chemical binding]; other site 1279365009172 dimer interface [polypeptide binding]; other site 1279365009173 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1279365009174 PYR/PP interface [polypeptide binding]; other site 1279365009175 dimer interface [polypeptide binding]; other site 1279365009176 TPP binding site [chemical binding]; other site 1279365009177 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365009178 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1279365009179 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1279365009180 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1279365009181 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1279365009182 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1279365009183 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365009184 putative NAD(P) binding site [chemical binding]; other site 1279365009185 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365009186 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365009187 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1279365009188 active site 1279365009189 Zn binding site [ion binding]; other site 1279365009190 Viral enhancin protein; Region: Enhancin; pfam03272 1279365009191 Peptidase M60-like family; Region: M60-like; pfam13402 1279365009192 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1279365009193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365009194 dimerization interface [polypeptide binding]; other site 1279365009195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365009196 dimer interface [polypeptide binding]; other site 1279365009197 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1279365009198 putative CheW interface [polypeptide binding]; other site 1279365009199 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1279365009200 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1279365009201 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1279365009202 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1279365009203 catalytic motif [active] 1279365009204 Zn binding site [ion binding]; other site 1279365009205 RibD C-terminal domain; Region: RibD_C; cl17279 1279365009206 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1279365009207 dimerization interface [polypeptide binding]; other site 1279365009208 active site 1279365009209 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365009210 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1279365009211 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1279365009212 dimer interface [polypeptide binding]; other site 1279365009213 FMN binding site [chemical binding]; other site 1279365009214 hypothetical protein; Provisional; Region: PRK02487 1279365009215 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1279365009216 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1279365009217 IDEAL domain; Region: IDEAL; pfam08858 1279365009218 Transcriptional regulator; Region: Rrf2; pfam02082 1279365009219 Rrf2 family protein; Region: rrf2_super; TIGR00738 1279365009220 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1279365009221 ArsC family; Region: ArsC; pfam03960 1279365009222 putative catalytic residues [active] 1279365009223 thiol/disulfide switch; other site 1279365009224 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1279365009225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365009226 DNA-binding site [nucleotide binding]; DNA binding site 1279365009227 UTRA domain; Region: UTRA; pfam07702 1279365009228 putative oxidoreductase; Provisional; Region: PRK10206 1279365009229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1279365009230 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1279365009231 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1279365009232 putative hydrophobic ligand binding site [chemical binding]; other site 1279365009233 protein interface [polypeptide binding]; other site 1279365009234 gate; other site 1279365009235 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1279365009236 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1279365009237 putative active site [active] 1279365009238 putative catalytic triad [active] 1279365009239 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1279365009240 oxyanion hole [active] 1279365009241 active site 1279365009242 catalytic triad [active] 1279365009243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365009244 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365009245 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1279365009246 substrate binding site [chemical binding]; other site 1279365009247 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1279365009248 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1279365009249 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1279365009250 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1279365009251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009252 Coenzyme A binding pocket [chemical binding]; other site 1279365009253 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365009254 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365009255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365009256 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365009257 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1279365009258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1279365009259 acyl-activating enzyme (AAE) consensus motif; other site 1279365009260 AMP binding site [chemical binding]; other site 1279365009261 active site 1279365009262 CoA binding site [chemical binding]; other site 1279365009263 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1279365009264 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365009265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365009266 dimerization interface [polypeptide binding]; other site 1279365009267 putative DNA binding site [nucleotide binding]; other site 1279365009268 putative Zn2+ binding site [ion binding]; other site 1279365009269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365009270 dimerization interface [polypeptide binding]; other site 1279365009271 putative DNA binding site [nucleotide binding]; other site 1279365009272 putative Zn2+ binding site [ion binding]; other site 1279365009273 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1279365009274 active site 1279365009275 Glyco_18 domain; Region: Glyco_18; smart00636 1279365009276 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1279365009277 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 1279365009278 NodB motif; other site 1279365009279 putative active site [active] 1279365009280 putative catalytic site [active] 1279365009281 putative Zn binding site [ion binding]; other site 1279365009282 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1279365009283 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1279365009284 DXD motif; other site 1279365009285 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1279365009286 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1279365009287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365009288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365009289 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1279365009290 active site 1279365009291 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1279365009292 HTH domain; Region: HTH_11; pfam08279 1279365009293 WYL domain; Region: WYL; pfam13280 1279365009294 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1279365009295 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1279365009296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365009297 Walker A/P-loop; other site 1279365009298 ATP binding site [chemical binding]; other site 1279365009299 Q-loop/lid; other site 1279365009300 ABC transporter signature motif; other site 1279365009301 Walker B; other site 1279365009302 D-loop; other site 1279365009303 H-loop/switch region; other site 1279365009304 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1279365009305 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365009306 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365009307 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1279365009308 hydroxylamine reductase; Provisional; Region: PRK12310 1279365009309 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1279365009310 ACS interaction site; other site 1279365009311 CODH interaction site; other site 1279365009312 metal cluster binding site [ion binding]; other site 1279365009313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365009314 hypothetical protein; Provisional; Region: PRK06771 1279365009315 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1279365009316 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1279365009317 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365009318 active site 1279365009319 metal binding site [ion binding]; metal-binding site 1279365009320 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1279365009321 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365009322 ligand binding site [chemical binding]; other site 1279365009323 flexible hinge region; other site 1279365009324 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1279365009325 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1279365009326 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1279365009327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365009328 putative transport protein YifK; Provisional; Region: PRK10746 1279365009329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365009330 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1279365009331 putative substrate translocation pore; other site 1279365009332 Haemolysin XhlA; Region: XhlA; pfam10779 1279365009333 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1279365009334 classical (c) SDRs; Region: SDR_c; cd05233 1279365009335 NAD(P) binding site [chemical binding]; other site 1279365009336 active site 1279365009337 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1279365009338 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1279365009339 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1279365009340 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1279365009341 transmembrane helices; other site 1279365009342 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365009343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009344 Coenzyme A binding pocket [chemical binding]; other site 1279365009345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365009346 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365009347 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1279365009348 putative ligand binding residues [chemical binding]; other site 1279365009349 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1279365009350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365009351 ABC-ATPase subunit interface; other site 1279365009352 dimer interface [polypeptide binding]; other site 1279365009353 putative PBP binding regions; other site 1279365009354 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365009355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365009356 ABC-ATPase subunit interface; other site 1279365009357 dimer interface [polypeptide binding]; other site 1279365009358 putative PBP binding regions; other site 1279365009359 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1279365009360 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1279365009361 DinB superfamily; Region: DinB_2; pfam12867 1279365009362 DinB family; Region: DinB; cl17821 1279365009363 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365009364 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365009365 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1279365009366 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1279365009367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365009368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365009369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365009370 dimerization interface [polypeptide binding]; other site 1279365009371 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365009372 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1279365009373 NADP binding site [chemical binding]; other site 1279365009374 dimer interface [polypeptide binding]; other site 1279365009375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1279365009376 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1279365009377 S-adenosylmethionine binding site [chemical binding]; other site 1279365009378 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365009379 catalytic core [active] 1279365009380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009381 Coenzyme A binding pocket [chemical binding]; other site 1279365009382 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 1279365009383 MutS domain III; Region: MutS_III; pfam05192 1279365009384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365009385 Walker A/P-loop; other site 1279365009386 ATP binding site [chemical binding]; other site 1279365009387 Q-loop/lid; other site 1279365009388 ABC transporter signature motif; other site 1279365009389 Walker B; other site 1279365009390 D-loop; other site 1279365009391 H-loop/switch region; other site 1279365009392 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1279365009393 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1279365009394 active site 1279365009395 Na/Ca binding site [ion binding]; other site 1279365009396 catalytic site [active] 1279365009397 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1279365009398 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1279365009399 oligoendopeptidase F; Region: pepF; TIGR00181 1279365009400 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1279365009401 active site 1279365009402 Zn binding site [ion binding]; other site 1279365009403 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1279365009404 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1279365009405 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1279365009406 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365009407 DNA binding residues [nucleotide binding] 1279365009408 drug binding residues [chemical binding]; other site 1279365009409 dimer interface [polypeptide binding]; other site 1279365009410 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1279365009411 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1279365009412 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1279365009413 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1279365009414 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365009415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365009416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365009417 putative substrate translocation pore; other site 1279365009418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365009419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365009420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365009421 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1279365009422 putative dimerization interface [polypeptide binding]; other site 1279365009423 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 1279365009424 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1279365009425 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1279365009426 active site 1279365009427 catalytic site [active] 1279365009428 metal binding site [ion binding]; metal-binding site 1279365009429 FAD binding domain; Region: FAD_binding_3; pfam01494 1279365009430 hypothetical protein; Provisional; Region: PRK07236 1279365009431 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1279365009432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365009433 dimerization interface [polypeptide binding]; other site 1279365009434 putative DNA binding site [nucleotide binding]; other site 1279365009435 putative Zn2+ binding site [ion binding]; other site 1279365009436 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1279365009437 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1279365009438 putative NAD(P) binding site [chemical binding]; other site 1279365009439 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1279365009440 hypothetical protein; Validated; Region: PRK00029 1279365009441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365009442 TPR motif; other site 1279365009443 binding surface 1279365009444 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1279365009445 Sodium Bile acid symporter family; Region: SBF; cl17470 1279365009446 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1279365009447 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365009448 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1279365009449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365009450 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365009451 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1279365009452 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1279365009453 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1279365009454 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1279365009455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365009456 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365009457 active site residue [active] 1279365009458 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1279365009459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365009460 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1279365009461 active site 1279365009462 catalytic site [active] 1279365009463 putative metal binding site [ion binding]; other site 1279365009464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1279365009465 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1279365009466 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365009467 Interdomain contacts; other site 1279365009468 Cytokine receptor motif; other site 1279365009469 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365009470 Interdomain contacts; other site 1279365009471 Cytokine receptor motif; other site 1279365009472 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1279365009473 Fic/DOC family; Region: Fic; pfam02661 1279365009474 Fic family protein [Function unknown]; Region: COG3177 1279365009475 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365009476 Spore germination protein; Region: Spore_permease; cl17796 1279365009477 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1279365009478 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365009479 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1279365009480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365009481 Integrase core domain; Region: rve; pfam00665 1279365009482 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365009483 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365009484 putative active site [active] 1279365009485 putative NTP binding site [chemical binding]; other site 1279365009486 putative nucleic acid binding site [nucleotide binding]; other site 1279365009487 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365009488 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365009489 transposase/IS protein; Provisional; Region: PRK09183 1279365009490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365009491 Walker A motif; other site 1279365009492 ATP binding site [chemical binding]; other site 1279365009493 Walker B motif; other site 1279365009494 arginine finger; other site 1279365009495 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1279365009496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365009497 active site 1279365009498 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1279365009499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365009500 NAD(P) binding site [chemical binding]; other site 1279365009501 active site 1279365009502 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1279365009503 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1279365009504 NAD binding site [chemical binding]; other site 1279365009505 homotetramer interface [polypeptide binding]; other site 1279365009506 homodimer interface [polypeptide binding]; other site 1279365009507 substrate binding site [chemical binding]; other site 1279365009508 active site 1279365009509 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365009510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365009511 TPR motif; other site 1279365009512 binding surface 1279365009513 Tar ligand binding domain homologue; Region: TarH; pfam02203 1279365009514 Cache domain; Region: Cache_1; pfam02743 1279365009515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365009516 dimerization interface [polypeptide binding]; other site 1279365009517 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365009518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365009519 dimer interface [polypeptide binding]; other site 1279365009520 putative CheW interface [polypeptide binding]; other site 1279365009521 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 1279365009522 PKC phosphorylation site [posttranslational modification]; other site 1279365009523 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1279365009524 putative active site [active] 1279365009525 putative catalytic triad [active] 1279365009526 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 1279365009527 Peptidase M60-like family; Region: M60-like; pfam13402 1279365009528 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1279365009529 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365009530 Interdomain contacts; other site 1279365009531 Cytokine receptor motif; other site 1279365009532 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1279365009533 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1279365009534 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365009535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365009536 TPR motif; other site 1279365009537 binding surface 1279365009538 PAS domain S-box; Region: sensory_box; TIGR00229 1279365009539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365009540 putative active site [active] 1279365009541 heme pocket [chemical binding]; other site 1279365009542 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365009543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365009544 metal binding site [ion binding]; metal-binding site 1279365009545 active site 1279365009546 I-site; other site 1279365009547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365009548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365009549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365009550 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365009551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365009552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365009553 TQXA domain; Region: TQXA_dom; TIGR03934 1279365009554 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365009555 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365009556 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365009557 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365009558 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1279365009559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365009560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365009561 dimer interface [polypeptide binding]; other site 1279365009562 phosphorylation site [posttranslational modification] 1279365009563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365009564 ATP binding site [chemical binding]; other site 1279365009565 Mg2+ binding site [ion binding]; other site 1279365009566 G-X-G motif; other site 1279365009567 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1279365009568 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365009569 FOG: PKD repeat [General function prediction only]; Region: COG3291 1279365009570 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1279365009571 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1279365009572 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1279365009573 MgtC family; Region: MgtC; pfam02308 1279365009574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365009575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009576 Coenzyme A binding pocket [chemical binding]; other site 1279365009577 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1279365009578 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1279365009579 putative metal binding site [ion binding]; other site 1279365009580 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365009581 active site 1279365009582 VanW like protein; Region: VanW; pfam04294 1279365009583 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1279365009584 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1279365009585 exonuclease; Provisional; Region: PRK06722 1279365009586 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1279365009587 active site 1279365009588 catalytic site [active] 1279365009589 substrate binding site [chemical binding]; other site 1279365009590 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1279365009591 DNA-binding site [nucleotide binding]; DNA binding site 1279365009592 RNA-binding motif; other site 1279365009593 flavodoxin; Provisional; Region: PRK06703 1279365009594 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1279365009595 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1279365009596 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1279365009597 nudix motif; other site 1279365009598 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 1279365009599 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1279365009600 trimer interface [polypeptide binding]; other site 1279365009601 active site 1279365009602 substrate binding site [chemical binding]; other site 1279365009603 CoA binding site [chemical binding]; other site 1279365009604 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009605 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009606 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009607 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009608 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009609 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009610 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009611 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009612 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009613 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009614 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009615 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009616 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009617 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365009618 short chain dehydrogenase; Provisional; Region: PRK06924 1279365009619 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1279365009620 NADP binding site [chemical binding]; other site 1279365009621 homodimer interface [polypeptide binding]; other site 1279365009622 active site 1279365009623 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1279365009624 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365009625 Coenzyme A binding pocket [chemical binding]; other site 1279365009626 argininosuccinate lyase; Provisional; Region: PRK06705 1279365009627 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1279365009628 active sites [active] 1279365009629 tetramer interface [polypeptide binding]; other site 1279365009630 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365009631 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365009632 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1279365009633 active site 1279365009634 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1279365009635 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1279365009636 Na binding site [ion binding]; other site 1279365009637 Protein of unknown function (DUF997); Region: DUF997; pfam06196 1279365009638 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1279365009639 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1279365009640 NAD(P) binding site [chemical binding]; other site 1279365009641 catalytic residues [active] 1279365009642 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1279365009643 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1279365009644 NAD(P) binding site [chemical binding]; other site 1279365009645 homotetramer interface [polypeptide binding]; other site 1279365009646 homodimer interface [polypeptide binding]; other site 1279365009647 active site 1279365009648 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1279365009649 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1279365009650 Divergent PAP2 family; Region: DUF212; pfam02681 1279365009651 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1279365009652 EamA-like transporter family; Region: EamA; pfam00892 1279365009653 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1279365009654 Domain of unknown function DUF59; Region: DUF59; pfam01883 1279365009655 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1279365009656 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1279365009657 Walker A motif; other site 1279365009658 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1279365009659 MoaE interaction surface [polypeptide binding]; other site 1279365009660 MoeB interaction surface [polypeptide binding]; other site 1279365009661 thiocarboxylated glycine; other site 1279365009662 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1279365009663 MoaE homodimer interface [polypeptide binding]; other site 1279365009664 MoaD interaction [polypeptide binding]; other site 1279365009665 active site residues [active] 1279365009666 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1279365009667 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1279365009668 dimer interface [polypeptide binding]; other site 1279365009669 putative functional site; other site 1279365009670 putative MPT binding site; other site 1279365009671 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1279365009672 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1279365009673 ATP binding site [chemical binding]; other site 1279365009674 substrate interface [chemical binding]; other site 1279365009675 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1279365009676 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1279365009677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365009678 FeS/SAM binding site; other site 1279365009679 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1279365009680 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1279365009681 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1279365009682 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1279365009683 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1279365009684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1279365009685 catalytic loop [active] 1279365009686 iron binding site [ion binding]; other site 1279365009687 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1279365009688 4Fe-4S binding domain; Region: Fer4; pfam00037 1279365009689 4Fe-4S binding domain; Region: Fer4; pfam00037 1279365009690 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1279365009691 [4Fe-4S] binding site [ion binding]; other site 1279365009692 molybdopterin cofactor binding site; other site 1279365009693 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1279365009694 molybdopterin cofactor binding site; other site 1279365009695 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365009696 Spore germination protein; Region: Spore_permease; cl17796 1279365009697 Spore germination protein; Region: Spore_permease; cl17796 1279365009698 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1279365009699 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365009700 amino acid transporter; Region: 2A0306; TIGR00909 1279365009701 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1279365009702 Tubulin like; Region: Tubulin_2; pfam13809 1279365009703 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1279365009704 metal ion-dependent adhesion site (MIDAS); other site 1279365009705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365009706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1279365009707 active site 1279365009708 metal binding site [ion binding]; metal-binding site 1279365009709 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1279365009710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365009711 S-adenosylmethionine binding site [chemical binding]; other site 1279365009712 O-methyltransferase; Region: Methyltransf_2; pfam00891 1279365009713 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365009714 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365009715 peptide binding site [polypeptide binding]; other site 1279365009716 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365009717 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365009718 peptide binding site [polypeptide binding]; other site 1279365009719 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365009720 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365009721 peptide binding site [polypeptide binding]; other site 1279365009722 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1279365009723 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1279365009724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365009725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365009726 DNA binding residues [nucleotide binding] 1279365009727 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1279365009728 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365009729 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365009730 Walker A/P-loop; other site 1279365009731 ATP binding site [chemical binding]; other site 1279365009732 Q-loop/lid; other site 1279365009733 ABC transporter signature motif; other site 1279365009734 Walker B; other site 1279365009735 D-loop; other site 1279365009736 H-loop/switch region; other site 1279365009737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365009738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365009739 Predicted transcriptional regulator [Transcription]; Region: COG2378 1279365009740 HTH domain; Region: HTH_11; pfam08279 1279365009741 WYL domain; Region: WYL; pfam13280 1279365009742 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1279365009743 dimer interface [polypeptide binding]; other site 1279365009744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365009745 putative oxidoreductase; Provisional; Region: PRK11579 1279365009746 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1279365009747 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1279365009748 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1279365009749 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1279365009750 CAP-like domain; other site 1279365009751 active site 1279365009752 primary dimer interface [polypeptide binding]; other site 1279365009753 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365009754 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365009755 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365009756 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1279365009757 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1279365009758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365009759 ATP binding site [chemical binding]; other site 1279365009760 Mg2+ binding site [ion binding]; other site 1279365009761 G-X-G motif; other site 1279365009762 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1279365009763 anchoring element; other site 1279365009764 dimer interface [polypeptide binding]; other site 1279365009765 ATP binding site [chemical binding]; other site 1279365009766 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1279365009767 active site 1279365009768 putative metal-binding site [ion binding]; other site 1279365009769 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1279365009770 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1279365009771 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1279365009772 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1279365009773 protein binding site [polypeptide binding]; other site 1279365009774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365009775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365009776 active site 1279365009777 phosphorylation site [posttranslational modification] 1279365009778 intermolecular recognition site; other site 1279365009779 dimerization interface [polypeptide binding]; other site 1279365009780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365009781 DNA binding site [nucleotide binding] 1279365009782 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1279365009783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365009784 FeS/SAM binding site; other site 1279365009785 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 1279365009786 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1279365009787 effector binding site; other site 1279365009788 active site 1279365009789 Zn binding site [ion binding]; other site 1279365009790 glycine loop; other site 1279365009791 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1279365009792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1279365009793 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1279365009794 active site 1279365009795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1279365009796 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1279365009797 Probable transposase; Region: OrfB_IS605; pfam01385 1279365009798 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1279365009799 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1279365009800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365009801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365009802 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1279365009803 active site 1279365009804 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1279365009805 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1279365009806 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 1279365009807 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1279365009808 active site 1279365009809 catalytic site [active] 1279365009810 substrate binding site [chemical binding]; other site 1279365009811 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1279365009812 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1279365009813 catalytic residues [active] 1279365009814 YmzC-like protein; Region: YmzC; pfam14157 1279365009815 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365009816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365009817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365009818 Walker A/P-loop; other site 1279365009819 ATP binding site [chemical binding]; other site 1279365009820 Q-loop/lid; other site 1279365009821 ABC transporter signature motif; other site 1279365009822 Walker B; other site 1279365009823 D-loop; other site 1279365009824 H-loop/switch region; other site 1279365009825 aconitate hydratase; Validated; Region: PRK09277 1279365009826 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1279365009827 substrate binding site [chemical binding]; other site 1279365009828 ligand binding site [chemical binding]; other site 1279365009829 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1279365009830 substrate binding site [chemical binding]; other site 1279365009831 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1279365009832 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365009833 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1279365009834 NodB motif; other site 1279365009835 active site 1279365009836 catalytic site [active] 1279365009837 metal binding site [ion binding]; metal-binding site 1279365009838 Small acid-soluble spore protein P family; Region: SspP; cl12105 1279365009839 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1279365009840 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1279365009841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365009842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365009843 putative substrate translocation pore; other site 1279365009844 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1279365009845 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1279365009846 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1279365009847 nudix motif; other site 1279365009848 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1279365009849 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1279365009850 dimer interface [polypeptide binding]; other site 1279365009851 active site 1279365009852 acyl-CoA synthetase; Validated; Region: PRK07638 1279365009853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1279365009854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1279365009855 acyl-activating enzyme (AAE) consensus motif; other site 1279365009856 acyl-activating enzyme (AAE) consensus motif; other site 1279365009857 AMP binding site [chemical binding]; other site 1279365009858 active site 1279365009859 CoA binding site [chemical binding]; other site 1279365009860 BioY family; Region: BioY; pfam02632 1279365009861 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1279365009862 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1279365009863 dimer interface [polypeptide binding]; other site 1279365009864 acyl-activating enzyme (AAE) consensus motif; other site 1279365009865 putative active site [active] 1279365009866 AMP binding site [chemical binding]; other site 1279365009867 putative CoA binding site [chemical binding]; other site 1279365009868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365009869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365009870 non-specific DNA binding site [nucleotide binding]; other site 1279365009871 salt bridge; other site 1279365009872 sequence-specific DNA binding site [nucleotide binding]; other site 1279365009873 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365009874 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365009875 Coenzyme A binding pocket [chemical binding]; other site 1279365009876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365009877 Coenzyme A binding pocket [chemical binding]; other site 1279365009878 High-affinity nickel-transport protein; Region: NicO; cl00964 1279365009879 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1279365009880 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1279365009881 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1279365009882 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1279365009883 UreF; Region: UreF; pfam01730 1279365009884 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1279365009885 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1279365009886 dimer interface [polypeptide binding]; other site 1279365009887 catalytic residues [active] 1279365009888 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1279365009889 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1279365009890 subunit interactions [polypeptide binding]; other site 1279365009891 active site 1279365009892 flap region; other site 1279365009893 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1279365009894 gamma-beta subunit interface [polypeptide binding]; other site 1279365009895 alpha-beta subunit interface [polypeptide binding]; other site 1279365009896 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1279365009897 alpha-gamma subunit interface [polypeptide binding]; other site 1279365009898 beta-gamma subunit interface [polypeptide binding]; other site 1279365009899 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1279365009900 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365009901 amidase catalytic site [active] 1279365009902 Zn binding residues [ion binding]; other site 1279365009903 substrate binding site [chemical binding]; other site 1279365009904 active site 1279365009905 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1279365009906 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365009907 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365009908 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365009909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365009910 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1279365009911 dimer interface [polypeptide binding]; other site 1279365009912 putative metal binding site [ion binding]; other site 1279365009913 PAS domain S-box; Region: sensory_box; TIGR00229 1279365009914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365009915 putative active site [active] 1279365009916 heme pocket [chemical binding]; other site 1279365009917 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1279365009918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365009919 putative active site [active] 1279365009920 heme pocket [chemical binding]; other site 1279365009921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365009922 dimer interface [polypeptide binding]; other site 1279365009923 phosphorylation site [posttranslational modification] 1279365009924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365009925 ATP binding site [chemical binding]; other site 1279365009926 Mg2+ binding site [ion binding]; other site 1279365009927 G-X-G motif; other site 1279365009928 Predicted esterase [General function prediction only]; Region: COG0400 1279365009929 putative hydrolase; Provisional; Region: PRK11460 1279365009930 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1279365009931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365009932 Zn binding site [ion binding]; other site 1279365009933 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1279365009934 Zn binding site [ion binding]; other site 1279365009935 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365009936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365009937 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365009938 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1279365009939 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1279365009940 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1279365009941 active site 1279365009942 FMN binding site [chemical binding]; other site 1279365009943 substrate binding site [chemical binding]; other site 1279365009944 3Fe-4S cluster binding site [ion binding]; other site 1279365009945 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1279365009946 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1279365009947 FMN binding site [chemical binding]; other site 1279365009948 active site 1279365009949 substrate binding site [chemical binding]; other site 1279365009950 catalytic residue [active] 1279365009951 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365009952 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365009953 putative active site [active] 1279365009954 putative NTP binding site [chemical binding]; other site 1279365009955 putative nucleic acid binding site [nucleotide binding]; other site 1279365009956 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1279365009957 active site 1279365009958 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1279365009959 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1279365009960 agmatinase; Region: agmatinase; TIGR01230 1279365009961 Agmatinase-like family; Region: Agmatinase-like; cd09990 1279365009962 active site 1279365009963 oligomer interface [polypeptide binding]; other site 1279365009964 Mn binding site [ion binding]; other site 1279365009965 imidazolonepropionase; Validated; Region: PRK09356 1279365009966 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1279365009967 active site 1279365009968 urocanate hydratase; Provisional; Region: PRK05414 1279365009969 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1279365009970 active sites [active] 1279365009971 tetramer interface [polypeptide binding]; other site 1279365009972 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1279365009973 hexamer interface [polypeptide binding]; other site 1279365009974 RNA binding site [nucleotide binding]; other site 1279365009975 Histidine-zinc binding site [chemical binding]; other site 1279365009976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365009977 S-adenosylmethionine binding site [chemical binding]; other site 1279365009978 DJ-1 family protein; Region: not_thiJ; TIGR01383 1279365009979 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1279365009980 conserved cys residue [active] 1279365009981 AAA domain; Region: AAA_28; pfam13521 1279365009982 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1279365009983 active site 1279365009984 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1279365009985 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1279365009986 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1279365009987 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1279365009988 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1279365009989 EamA-like transporter family; Region: EamA; pfam00892 1279365009990 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1279365009991 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1279365009992 metal binding site [ion binding]; metal-binding site 1279365009993 dimer interface [polypeptide binding]; other site 1279365009994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365009995 Transposase; Region: HTH_Tnp_1; cl17663 1279365009996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365009997 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365009998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365009999 HTH-like domain; Region: HTH_21; pfam13276 1279365010000 Integrase core domain; Region: rve; pfam00665 1279365010001 Integrase core domain; Region: rve_2; pfam13333 1279365010002 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1279365010003 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1279365010004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365010005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365010006 Walker A/P-loop; other site 1279365010007 ATP binding site [chemical binding]; other site 1279365010008 Q-loop/lid; other site 1279365010009 ABC transporter signature motif; other site 1279365010010 Walker B; other site 1279365010011 D-loop; other site 1279365010012 H-loop/switch region; other site 1279365010013 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1279365010014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365010015 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1279365010016 putative dimerization interface [polypeptide binding]; other site 1279365010017 putative substrate binding pocket [chemical binding]; other site 1279365010018 holin-like protein; Validated; Region: PRK01658 1279365010019 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1279365010020 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1279365010021 nudix motif; other site 1279365010022 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 1279365010023 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1279365010024 Nuclease-related domain; Region: NERD; pfam08378 1279365010025 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1279365010026 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1279365010027 active site 1279365010028 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365010029 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1279365010030 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365010031 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365010032 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1279365010033 Walker A/P-loop; other site 1279365010034 ATP binding site [chemical binding]; other site 1279365010035 Q-loop/lid; other site 1279365010036 ABC transporter signature motif; other site 1279365010037 Walker B; other site 1279365010038 D-loop; other site 1279365010039 H-loop/switch region; other site 1279365010040 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365010041 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1279365010042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365010043 Walker A/P-loop; other site 1279365010044 ATP binding site [chemical binding]; other site 1279365010045 Q-loop/lid; other site 1279365010046 ABC transporter signature motif; other site 1279365010047 Walker B; other site 1279365010048 D-loop; other site 1279365010049 H-loop/switch region; other site 1279365010050 hypothetical protein; Provisional; Region: PRK01844 1279365010051 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1279365010052 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1279365010053 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1279365010054 TPP-binding site [chemical binding]; other site 1279365010055 dimer interface [polypeptide binding]; other site 1279365010056 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1279365010057 PYR/PP interface [polypeptide binding]; other site 1279365010058 dimer interface [polypeptide binding]; other site 1279365010059 TPP binding site [chemical binding]; other site 1279365010060 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365010061 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1279365010062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365010063 dimer interface [polypeptide binding]; other site 1279365010064 conserved gate region; other site 1279365010065 ABC-ATPase subunit interface; other site 1279365010066 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1279365010067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365010068 dimer interface [polypeptide binding]; other site 1279365010069 conserved gate region; other site 1279365010070 ABC-ATPase subunit interface; other site 1279365010071 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1279365010072 Walker A/P-loop; other site 1279365010073 ATP binding site [chemical binding]; other site 1279365010074 ABC transporter; Region: ABC_tran; pfam00005 1279365010075 Q-loop/lid; other site 1279365010076 ABC transporter signature motif; other site 1279365010077 Walker B; other site 1279365010078 D-loop; other site 1279365010079 H-loop/switch region; other site 1279365010080 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1279365010081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365010082 membrane-bound complex binding site; other site 1279365010083 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1279365010084 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1279365010085 active site 1279365010086 metal binding site [ion binding]; metal-binding site 1279365010087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365010088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365010089 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1279365010090 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1279365010091 hypothetical protein; Provisional; Region: PRK01546 1279365010092 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1279365010093 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1279365010094 catalytic residues [active] 1279365010095 catalytic nucleophile [active] 1279365010096 LexA repressor; Validated; Region: PRK00215 1279365010097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365010098 putative DNA binding site [nucleotide binding]; other site 1279365010099 putative Zn2+ binding site [ion binding]; other site 1279365010100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1279365010101 Catalytic site [active] 1279365010102 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1279365010103 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1279365010104 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1279365010105 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1279365010106 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365010107 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365010108 glutamine synthetase, type I; Region: GlnA; TIGR00653 1279365010109 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1279365010110 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1279365010111 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1279365010112 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365010113 DNA binding residues [nucleotide binding] 1279365010114 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1279365010115 Aluminium resistance protein; Region: Alum_res; pfam06838 1279365010116 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1279365010117 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1279365010118 HflX GTPase family; Region: HflX; cd01878 1279365010119 G1 box; other site 1279365010120 GTP/Mg2+ binding site [chemical binding]; other site 1279365010121 Switch I region; other site 1279365010122 G2 box; other site 1279365010123 G3 box; other site 1279365010124 Switch II region; other site 1279365010125 G4 box; other site 1279365010126 G5 box; other site 1279365010127 Predicted membrane protein [Function unknown]; Region: COG2860 1279365010128 UPF0126 domain; Region: UPF0126; pfam03458 1279365010129 UPF0126 domain; Region: UPF0126; pfam03458 1279365010130 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1279365010131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365010132 Walker A motif; other site 1279365010133 ATP binding site [chemical binding]; other site 1279365010134 Walker B motif; other site 1279365010135 arginine finger; other site 1279365010136 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1279365010137 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365010138 active site 1279365010139 catalytic residues [active] 1279365010140 DNA binding site [nucleotide binding] 1279365010141 Int/Topo IB signature motif; other site 1279365010142 Protein of unknown function (DUF3982); Region: DUF3982; pfam13138 1279365010143 bacterial Hfq-like; Region: Hfq; cd01716 1279365010144 hexamer interface [polypeptide binding]; other site 1279365010145 Sm1 motif; other site 1279365010146 RNA binding site [nucleotide binding]; other site 1279365010147 Sm2 motif; other site 1279365010148 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1279365010149 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1279365010150 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365010151 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365010152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1279365010153 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1279365010154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1279365010155 active site 1279365010156 phosphorylation site [posttranslational modification] 1279365010157 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1279365010158 active site 1279365010159 P-loop; other site 1279365010160 phosphorylation site [posttranslational modification] 1279365010161 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1279365010162 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1279365010163 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1279365010164 putative substrate binding site [chemical binding]; other site 1279365010165 putative ATP binding site [chemical binding]; other site 1279365010166 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1279365010167 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1279365010168 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1279365010169 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1279365010170 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1279365010171 dimer interface [polypeptide binding]; other site 1279365010172 active site 1279365010173 metal binding site [ion binding]; metal-binding site 1279365010174 Predicted membrane protein [Function unknown]; Region: COG2322 1279365010175 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1279365010176 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1279365010177 Glyco_18 domain; Region: Glyco_18; smart00636 1279365010178 putative active site [active] 1279365010179 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1279365010180 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365010181 putative active site [active] 1279365010182 putative metal binding site [ion binding]; other site 1279365010183 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1279365010184 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1279365010185 IHF dimer interface [polypeptide binding]; other site 1279365010186 IHF - DNA interface [nucleotide binding]; other site 1279365010187 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365010188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365010189 Coenzyme A binding pocket [chemical binding]; other site 1279365010190 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1279365010191 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1279365010192 metal-binding site [ion binding] 1279365010193 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1279365010194 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1279365010195 metal-binding site [ion binding] 1279365010196 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365010197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365010198 motif II; other site 1279365010199 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1279365010200 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1279365010201 metal-binding site [ion binding] 1279365010202 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1279365010203 putative homodimer interface [polypeptide binding]; other site 1279365010204 putative homotetramer interface [polypeptide binding]; other site 1279365010205 putative allosteric switch controlling residues; other site 1279365010206 putative metal binding site [ion binding]; other site 1279365010207 putative homodimer-homodimer interface [polypeptide binding]; other site 1279365010208 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1279365010209 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1279365010210 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1279365010211 Walker A/P-loop; other site 1279365010212 ATP binding site [chemical binding]; other site 1279365010213 Q-loop/lid; other site 1279365010214 ABC transporter signature motif; other site 1279365010215 Walker B; other site 1279365010216 D-loop; other site 1279365010217 H-loop/switch region; other site 1279365010218 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365010219 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365010220 ABC-ATPase subunit interface; other site 1279365010221 dimer interface [polypeptide binding]; other site 1279365010222 putative PBP binding regions; other site 1279365010223 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365010224 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365010225 ABC-ATPase subunit interface; other site 1279365010226 dimer interface [polypeptide binding]; other site 1279365010227 putative PBP binding regions; other site 1279365010228 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1279365010229 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1279365010230 putative ligand binding residues [chemical binding]; other site 1279365010231 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1279365010232 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1279365010233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365010234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365010235 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1279365010236 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1279365010237 DNA binding site [nucleotide binding] 1279365010238 active site 1279365010239 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1279365010240 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1279365010241 endonuclease III; Region: ENDO3c; smart00478 1279365010242 minor groove reading motif; other site 1279365010243 helix-hairpin-helix signature motif; other site 1279365010244 substrate binding pocket [chemical binding]; other site 1279365010245 active site 1279365010246 peptidase T; Region: peptidase-T; TIGR01882 1279365010247 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1279365010248 metal binding site [ion binding]; metal-binding site 1279365010249 dimer interface [polypeptide binding]; other site 1279365010250 hypothetical protein; Provisional; Region: PRK06764 1279365010251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365010252 catalytic core [active] 1279365010253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365010254 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1279365010255 PAS domain S-box; Region: sensory_box; TIGR00229 1279365010256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365010257 putative active site [active] 1279365010258 heme pocket [chemical binding]; other site 1279365010259 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365010260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365010261 metal binding site [ion binding]; metal-binding site 1279365010262 active site 1279365010263 I-site; other site 1279365010264 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365010265 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1279365010266 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1279365010267 active site 1279365010268 homodimer interface [polypeptide binding]; other site 1279365010269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365010270 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1279365010271 NAD(P) binding site [chemical binding]; other site 1279365010272 active site 1279365010273 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1279365010274 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1279365010275 NAD(P) binding site [chemical binding]; other site 1279365010276 homodimer interface [polypeptide binding]; other site 1279365010277 substrate binding site [chemical binding]; other site 1279365010278 active site 1279365010279 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1279365010280 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1279365010281 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1279365010282 holin-like protein; Validated; Region: PRK01658 1279365010283 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1279365010284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365010285 DNA-binding site [nucleotide binding]; DNA binding site 1279365010286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365010287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365010288 homodimer interface [polypeptide binding]; other site 1279365010289 catalytic residue [active] 1279365010290 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1279365010291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365010292 DNA-binding site [nucleotide binding]; DNA binding site 1279365010293 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1279365010294 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1279365010295 beta-galactosidase; Region: BGL; TIGR03356 1279365010296 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 1279365010297 active site 1279365010298 catalytic site [active] 1279365010299 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1279365010300 putative active site [active] 1279365010301 putative catalytic triad [active] 1279365010302 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1279365010303 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365010304 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1279365010305 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365010306 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1279365010307 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1279365010308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1279365010309 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1279365010310 Sulfatase; Region: Sulfatase; pfam00884 1279365010311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365010312 binding surface 1279365010313 TPR motif; other site 1279365010314 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1279365010315 G1 box; other site 1279365010316 GTP/Mg2+ binding site [chemical binding]; other site 1279365010317 Switch I region; other site 1279365010318 G3 box; other site 1279365010319 Switch II region; other site 1279365010320 G4 box; other site 1279365010321 G5 box; other site 1279365010322 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1279365010323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365010324 ATP binding site [chemical binding]; other site 1279365010325 Mg2+ binding site [ion binding]; other site 1279365010326 G-X-G motif; other site 1279365010327 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1279365010328 ATP binding site [chemical binding]; other site 1279365010329 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1279365010330 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1279365010331 MutS domain I; Region: MutS_I; pfam01624 1279365010332 MutS domain II; Region: MutS_II; pfam05188 1279365010333 MutS domain III; Region: MutS_III; pfam05192 1279365010334 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1279365010335 Walker A/P-loop; other site 1279365010336 ATP binding site [chemical binding]; other site 1279365010337 Q-loop/lid; other site 1279365010338 ABC transporter signature motif; other site 1279365010339 Walker B; other site 1279365010340 D-loop; other site 1279365010341 H-loop/switch region; other site 1279365010342 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1279365010343 Predicted membrane protein [Function unknown]; Region: COG4550 1279365010344 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1279365010345 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1279365010346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365010347 FeS/SAM binding site; other site 1279365010348 TRAM domain; Region: TRAM; pfam01938 1279365010349 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1279365010350 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1279365010351 TPP-binding site [chemical binding]; other site 1279365010352 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1279365010353 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1279365010354 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1279365010355 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1279365010356 dimer interface [polypeptide binding]; other site 1279365010357 PYR/PP interface [polypeptide binding]; other site 1279365010358 TPP binding site [chemical binding]; other site 1279365010359 substrate binding site [chemical binding]; other site 1279365010360 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365010361 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1279365010362 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1279365010363 active site 1279365010364 dimer interface [polypeptide binding]; other site 1279365010365 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1279365010366 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1279365010367 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1279365010368 putative active site [active] 1279365010369 metal binding site [ion binding]; metal-binding site 1279365010370 homodimer binding site [polypeptide binding]; other site 1279365010371 phosphodiesterase; Provisional; Region: PRK12704 1279365010372 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1279365010373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365010374 Zn2+ binding site [ion binding]; other site 1279365010375 Mg2+ binding site [ion binding]; other site 1279365010376 recombinase A; Provisional; Region: recA; PRK09354 1279365010377 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1279365010378 hexamer interface [polypeptide binding]; other site 1279365010379 Walker A motif; other site 1279365010380 ATP binding site [chemical binding]; other site 1279365010381 Walker B motif; other site 1279365010382 competence damage-inducible protein A; Provisional; Region: PRK00549 1279365010383 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1279365010384 putative MPT binding site; other site 1279365010385 Competence-damaged protein; Region: CinA; pfam02464 1279365010386 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1279365010387 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1279365010388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365010389 non-specific DNA binding site [nucleotide binding]; other site 1279365010390 salt bridge; other site 1279365010391 sequence-specific DNA binding site [nucleotide binding]; other site 1279365010392 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1279365010393 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1279365010394 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1279365010395 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1279365010396 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1279365010397 classical (c) SDRs; Region: SDR_c; cd05233 1279365010398 NAD(P) binding site [chemical binding]; other site 1279365010399 active site 1279365010400 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1279365010401 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1279365010402 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1279365010403 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1279365010404 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1279365010405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1279365010406 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1279365010407 TM-ABC transporter signature motif; other site 1279365010408 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1279365010409 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1279365010410 TM-ABC transporter signature motif; other site 1279365010411 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1279365010412 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1279365010413 Walker A/P-loop; other site 1279365010414 ATP binding site [chemical binding]; other site 1279365010415 Q-loop/lid; other site 1279365010416 ABC transporter signature motif; other site 1279365010417 Walker B; other site 1279365010418 D-loop; other site 1279365010419 H-loop/switch region; other site 1279365010420 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1279365010421 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1279365010422 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1279365010423 ligand binding site [chemical binding]; other site 1279365010424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365010425 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1279365010426 DNA-binding site [nucleotide binding]; DNA binding site 1279365010427 UTRA domain; Region: UTRA; pfam07702 1279365010428 Tetraspanin family; Region: Tetraspannin; pfam00335 1279365010429 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1279365010430 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365010431 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1279365010432 YlzJ-like protein; Region: YlzJ; pfam14035 1279365010433 Clp protease; Region: CLP_protease; pfam00574 1279365010434 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1279365010435 active site 1279365010436 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1279365010437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365010438 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1279365010439 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1279365010440 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1279365010441 dimer interface [polypeptide binding]; other site 1279365010442 active site 1279365010443 catalytic residue [active] 1279365010444 aspartate kinase I; Reviewed; Region: PRK08210 1279365010445 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1279365010446 nucleotide binding site [chemical binding]; other site 1279365010447 substrate binding site [chemical binding]; other site 1279365010448 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1279365010449 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1279365010450 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1279365010451 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1279365010452 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1279365010453 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1279365010454 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1279365010455 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1279365010456 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1279365010457 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1279365010458 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1279365010459 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1279365010460 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1279365010461 NodB motif; other site 1279365010462 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1279365010463 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1279365010464 RNase E interface [polypeptide binding]; other site 1279365010465 trimer interface [polypeptide binding]; other site 1279365010466 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1279365010467 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1279365010468 RNase E interface [polypeptide binding]; other site 1279365010469 trimer interface [polypeptide binding]; other site 1279365010470 active site 1279365010471 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1279365010472 putative nucleic acid binding region [nucleotide binding]; other site 1279365010473 G-X-X-G motif; other site 1279365010474 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1279365010475 RNA binding site [nucleotide binding]; other site 1279365010476 domain interface; other site 1279365010477 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1279365010478 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1279365010479 active site 1279365010480 Riboflavin kinase; Region: Flavokinase; pfam01687 1279365010481 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1279365010482 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1279365010483 RNA binding site [nucleotide binding]; other site 1279365010484 active site 1279365010485 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1279365010486 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1279365010487 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1279365010488 translation initiation factor IF-2; Region: IF-2; TIGR00487 1279365010489 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1279365010490 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1279365010491 G1 box; other site 1279365010492 putative GEF interaction site [polypeptide binding]; other site 1279365010493 GTP/Mg2+ binding site [chemical binding]; other site 1279365010494 Switch I region; other site 1279365010495 G2 box; other site 1279365010496 G3 box; other site 1279365010497 Switch II region; other site 1279365010498 G4 box; other site 1279365010499 G5 box; other site 1279365010500 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1279365010501 Translation-initiation factor 2; Region: IF-2; pfam11987 1279365010502 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1279365010503 hypothetical protein; Provisional; Region: PRK07714 1279365010504 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1279365010505 putative RNA binding cleft [nucleotide binding]; other site 1279365010506 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1279365010507 NusA N-terminal domain; Region: NusA_N; pfam08529 1279365010508 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1279365010509 RNA binding site [nucleotide binding]; other site 1279365010510 homodimer interface [polypeptide binding]; other site 1279365010511 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1279365010512 G-X-X-G motif; other site 1279365010513 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1279365010514 G-X-X-G motif; other site 1279365010515 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1279365010516 Sm and related proteins; Region: Sm_like; cl00259 1279365010517 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1279365010518 putative oligomer interface [polypeptide binding]; other site 1279365010519 putative RNA binding site [nucleotide binding]; other site 1279365010520 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1279365010521 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1279365010522 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1279365010523 generic binding surface II; other site 1279365010524 generic binding surface I; other site 1279365010525 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1279365010526 active site 1279365010527 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1279365010528 active site 1279365010529 catalytic site [active] 1279365010530 substrate binding site [chemical binding]; other site 1279365010531 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1279365010532 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1279365010533 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1279365010534 dimer interface [polypeptide binding]; other site 1279365010535 motif 1; other site 1279365010536 active site 1279365010537 motif 2; other site 1279365010538 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1279365010539 putative deacylase active site [active] 1279365010540 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1279365010541 active site 1279365010542 motif 3; other site 1279365010543 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1279365010544 anticodon binding site; other site 1279365010545 RIP metalloprotease RseP; Region: TIGR00054 1279365010546 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1279365010547 active site 1279365010548 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1279365010549 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1279365010550 protein binding site [polypeptide binding]; other site 1279365010551 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1279365010552 putative substrate binding region [chemical binding]; other site 1279365010553 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1279365010554 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1279365010555 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1279365010556 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1279365010557 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1279365010558 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1279365010559 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1279365010560 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1279365010561 catalytic residue [active] 1279365010562 putative FPP diphosphate binding site; other site 1279365010563 putative FPP binding hydrophobic cleft; other site 1279365010564 dimer interface [polypeptide binding]; other site 1279365010565 putative IPP diphosphate binding site; other site 1279365010566 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1279365010567 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1279365010568 hinge region; other site 1279365010569 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1279365010570 putative nucleotide binding site [chemical binding]; other site 1279365010571 uridine monophosphate binding site [chemical binding]; other site 1279365010572 homohexameric interface [polypeptide binding]; other site 1279365010573 elongation factor Ts; Provisional; Region: tsf; PRK09377 1279365010574 UBA/TS-N domain; Region: UBA; pfam00627 1279365010575 Elongation factor TS; Region: EF_TS; pfam00889 1279365010576 Elongation factor TS; Region: EF_TS; pfam00889 1279365010577 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1279365010578 rRNA interaction site [nucleotide binding]; other site 1279365010579 S8 interaction site; other site 1279365010580 putative laminin-1 binding site; other site 1279365010581 transcriptional repressor CodY; Validated; Region: PRK04158 1279365010582 CodY GAF-like domain; Region: CodY; pfam06018 1279365010583 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1279365010584 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1279365010585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365010586 Walker A motif; other site 1279365010587 ATP binding site [chemical binding]; other site 1279365010588 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1279365010589 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1279365010590 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1279365010591 active site 1279365010592 HslU subunit interaction site [polypeptide binding]; other site 1279365010593 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1279365010594 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1279365010595 active site 1279365010596 Int/Topo IB signature motif; other site 1279365010597 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1279365010598 Glucose inhibited division protein A; Region: GIDA; pfam01134 1279365010599 DNA topoisomerase I; Validated; Region: PRK05582 1279365010600 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1279365010601 active site 1279365010602 interdomain interaction site; other site 1279365010603 putative metal-binding site [ion binding]; other site 1279365010604 nucleotide binding site [chemical binding]; other site 1279365010605 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1279365010606 domain I; other site 1279365010607 DNA binding groove [nucleotide binding] 1279365010608 phosphate binding site [ion binding]; other site 1279365010609 domain II; other site 1279365010610 domain III; other site 1279365010611 nucleotide binding site [chemical binding]; other site 1279365010612 catalytic site [active] 1279365010613 domain IV; other site 1279365010614 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1279365010615 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1279365010616 DNA protecting protein DprA; Region: dprA; TIGR00732 1279365010617 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1279365010618 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1279365010619 CoA binding domain; Region: CoA_binding; smart00881 1279365010620 CoA-ligase; Region: Ligase_CoA; pfam00549 1279365010621 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1279365010622 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1279365010623 CoA-ligase; Region: Ligase_CoA; pfam00549 1279365010624 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1279365010625 RNA/DNA hybrid binding site [nucleotide binding]; other site 1279365010626 active site 1279365010627 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1279365010628 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1279365010629 GTP/Mg2+ binding site [chemical binding]; other site 1279365010630 G4 box; other site 1279365010631 G5 box; other site 1279365010632 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1279365010633 G1 box; other site 1279365010634 G1 box; other site 1279365010635 GTP/Mg2+ binding site [chemical binding]; other site 1279365010636 Switch I region; other site 1279365010637 G2 box; other site 1279365010638 G2 box; other site 1279365010639 G3 box; other site 1279365010640 G3 box; other site 1279365010641 Switch II region; other site 1279365010642 Switch II region; other site 1279365010643 G4 box; other site 1279365010644 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1279365010645 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1279365010646 Catalytic site [active] 1279365010647 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1279365010648 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1279365010649 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1279365010650 RimM N-terminal domain; Region: RimM; pfam01782 1279365010651 PRC-barrel domain; Region: PRC; pfam05239 1279365010652 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1279365010653 KH domain; Region: KH_4; pfam13083 1279365010654 G-X-X-G motif; other site 1279365010655 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1279365010656 signal recognition particle protein; Provisional; Region: PRK10867 1279365010657 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1279365010658 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1279365010659 P loop; other site 1279365010660 GTP binding site [chemical binding]; other site 1279365010661 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1279365010662 putative DNA-binding protein; Validated; Region: PRK00118 1279365010663 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1279365010664 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1279365010665 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1279365010666 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1279365010667 P loop; other site 1279365010668 GTP binding site [chemical binding]; other site 1279365010669 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1279365010670 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1279365010671 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1279365010672 ABC transporter signature motif; other site 1279365010673 Walker B; other site 1279365010674 D-loop; other site 1279365010675 H-loop/switch region; other site 1279365010676 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365010677 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365010678 putative active site [active] 1279365010679 putative NTP binding site [chemical binding]; other site 1279365010680 putative nucleic acid binding site [nucleotide binding]; other site 1279365010681 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1279365010682 active site 1279365010683 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1279365010684 Walker A/P-loop; other site 1279365010685 ATP binding site [chemical binding]; other site 1279365010686 Q-loop/lid; other site 1279365010687 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1279365010688 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1279365010689 dimerization interface [polypeptide binding]; other site 1279365010690 active site 1279365010691 metal binding site [ion binding]; metal-binding site 1279365010692 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1279365010693 dsRNA binding site [nucleotide binding]; other site 1279365010694 acyl carrier protein; Provisional; Region: acpP; PRK00982 1279365010695 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1279365010696 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1279365010697 NAD(P) binding site [chemical binding]; other site 1279365010698 homotetramer interface [polypeptide binding]; other site 1279365010699 homodimer interface [polypeptide binding]; other site 1279365010700 active site 1279365010701 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1279365010702 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1279365010703 putative phosphate acyltransferase; Provisional; Region: PRK05331 1279365010704 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1279365010705 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1279365010706 active site 2 [active] 1279365010707 active site 1 [active] 1279365010708 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1279365010709 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1279365010710 generic binding surface II; other site 1279365010711 ssDNA binding site; other site 1279365010712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365010713 ATP binding site [chemical binding]; other site 1279365010714 putative Mg++ binding site [ion binding]; other site 1279365010715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365010716 nucleotide binding region [chemical binding]; other site 1279365010717 ATP-binding site [chemical binding]; other site 1279365010718 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1279365010719 DAK2 domain; Region: Dak2; pfam02734 1279365010720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1279365010721 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1279365010722 Thiamine pyrophosphokinase; Region: TPK; cd07995 1279365010723 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1279365010724 active site 1279365010725 dimerization interface [polypeptide binding]; other site 1279365010726 thiamine binding site [chemical binding]; other site 1279365010727 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1279365010728 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1279365010729 substrate binding site [chemical binding]; other site 1279365010730 hexamer interface [polypeptide binding]; other site 1279365010731 metal binding site [ion binding]; metal-binding site 1279365010732 GTPase RsgA; Reviewed; Region: PRK00098 1279365010733 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1279365010734 RNA binding site [nucleotide binding]; other site 1279365010735 homodimer interface [polypeptide binding]; other site 1279365010736 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1279365010737 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1279365010738 GTP/Mg2+ binding site [chemical binding]; other site 1279365010739 G4 box; other site 1279365010740 G5 box; other site 1279365010741 G1 box; other site 1279365010742 Switch I region; other site 1279365010743 G2 box; other site 1279365010744 G3 box; other site 1279365010745 Switch II region; other site 1279365010746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1279365010747 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1279365010748 active site 1279365010749 ATP binding site [chemical binding]; other site 1279365010750 substrate binding site [chemical binding]; other site 1279365010751 activation loop (A-loop); other site 1279365010752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1279365010753 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1279365010754 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1279365010755 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1279365010756 Protein phosphatase 2C; Region: PP2C; pfam00481 1279365010757 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1279365010758 active site 1279365010759 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1279365010760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365010761 FeS/SAM binding site; other site 1279365010762 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1279365010763 NusB family; Region: NusB; pfam01029 1279365010764 putative RNA binding site [nucleotide binding]; other site 1279365010765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365010766 S-adenosylmethionine binding site [chemical binding]; other site 1279365010767 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1279365010768 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1279365010769 putative active site [active] 1279365010770 substrate binding site [chemical binding]; other site 1279365010771 putative cosubstrate binding site; other site 1279365010772 catalytic site [active] 1279365010773 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1279365010774 substrate binding site [chemical binding]; other site 1279365010775 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1279365010776 active site 1279365010777 catalytic residues [active] 1279365010778 metal binding site [ion binding]; metal-binding site 1279365010779 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1279365010780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365010781 ATP binding site [chemical binding]; other site 1279365010782 putative Mg++ binding site [ion binding]; other site 1279365010783 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1279365010784 nucleotide binding region [chemical binding]; other site 1279365010785 ATP-binding site [chemical binding]; other site 1279365010786 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1279365010787 Flavoprotein; Region: Flavoprotein; pfam02441 1279365010788 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1279365010789 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1279365010790 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1279365010791 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1279365010792 catalytic site [active] 1279365010793 G-X2-G-X-G-K; other site 1279365010794 hypothetical protein; Provisional; Region: PRK04323 1279365010795 hypothetical protein; Provisional; Region: PRK11820 1279365010796 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1279365010797 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1279365010798 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1279365010799 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1279365010800 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365010801 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1279365010802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365010803 motif II; other site 1279365010804 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1279365010805 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1279365010806 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1279365010807 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1279365010808 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1279365010809 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1279365010810 active site 1279365010811 YoqO-like protein; Region: YoqO; pfam14037 1279365010812 YoqO-like protein; Region: YoqO; pfam14037 1279365010813 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1279365010814 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1279365010815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365010816 active site 1279365010817 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1279365010818 active site 1279365010819 dimer interface [polypeptide binding]; other site 1279365010820 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1279365010821 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1279365010822 heterodimer interface [polypeptide binding]; other site 1279365010823 active site 1279365010824 FMN binding site [chemical binding]; other site 1279365010825 homodimer interface [polypeptide binding]; other site 1279365010826 substrate binding site [chemical binding]; other site 1279365010827 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1279365010828 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1279365010829 FAD binding pocket [chemical binding]; other site 1279365010830 FAD binding motif [chemical binding]; other site 1279365010831 phosphate binding motif [ion binding]; other site 1279365010832 beta-alpha-beta structure motif; other site 1279365010833 NAD binding pocket [chemical binding]; other site 1279365010834 Iron coordination center [ion binding]; other site 1279365010835 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1279365010836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1279365010837 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1279365010838 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1279365010839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1279365010840 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1279365010841 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1279365010842 IMP binding site; other site 1279365010843 dimer interface [polypeptide binding]; other site 1279365010844 interdomain contacts; other site 1279365010845 partial ornithine binding site; other site 1279365010846 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1279365010847 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1279365010848 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1279365010849 catalytic site [active] 1279365010850 subunit interface [polypeptide binding]; other site 1279365010851 dihydroorotase; Validated; Region: pyrC; PRK09357 1279365010852 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1279365010853 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1279365010854 active site 1279365010855 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1279365010856 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1279365010857 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1279365010858 uracil transporter; Provisional; Region: PRK10720 1279365010859 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1279365010860 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365010861 active site 1279365010862 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1279365010863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365010864 RNA binding surface [nucleotide binding]; other site 1279365010865 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1279365010866 active site 1279365010867 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1279365010868 lipoprotein signal peptidase; Provisional; Region: PRK14787 1279365010869 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1279365010870 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1279365010871 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1279365010872 active site 1279365010873 HIGH motif; other site 1279365010874 nucleotide binding site [chemical binding]; other site 1279365010875 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1279365010876 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1279365010877 active site 1279365010878 KMSKS motif; other site 1279365010879 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1279365010880 tRNA binding surface [nucleotide binding]; other site 1279365010881 anticodon binding site; other site 1279365010882 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1279365010883 DivIVA protein; Region: DivIVA; pfam05103 1279365010884 DivIVA domain; Region: DivI1A_domain; TIGR03544 1279365010885 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1279365010886 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1279365010887 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365010888 RNA binding surface [nucleotide binding]; other site 1279365010889 YGGT family; Region: YGGT; pfam02325 1279365010890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1279365010891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1279365010892 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1279365010893 catalytic residue [active] 1279365010894 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1279365010895 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1279365010896 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1279365010897 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1279365010898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365010899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365010900 DNA binding residues [nucleotide binding] 1279365010901 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1279365010902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365010903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365010904 DNA binding residues [nucleotide binding] 1279365010905 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1279365010906 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1279365010907 cell division protein FtsZ; Validated; Region: PRK09330 1279365010908 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1279365010909 nucleotide binding site [chemical binding]; other site 1279365010910 SulA interaction site; other site 1279365010911 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1279365010912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1279365010913 nucleotide binding site [chemical binding]; other site 1279365010914 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1279365010915 Cell division protein FtsA; Region: FtsA; pfam14450 1279365010916 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1279365010917 Cell division protein FtsQ; Region: FtsQ; pfam03799 1279365010918 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1279365010919 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365010920 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1279365010921 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1279365010922 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1279365010923 active site 1279365010924 homodimer interface [polypeptide binding]; other site 1279365010925 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1279365010926 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1279365010927 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1279365010928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1279365010929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1279365010930 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1279365010931 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1279365010932 Mg++ binding site [ion binding]; other site 1279365010933 putative catalytic motif [active] 1279365010934 putative substrate binding site [chemical binding]; other site 1279365010935 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1279365010936 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1279365010937 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1279365010938 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1279365010939 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1279365010940 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365010941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365010942 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1279365010943 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365010944 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365010945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365010946 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1279365010947 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1279365010948 Cell division protein FtsL; Region: FtsL; cl11433 1279365010949 MraW methylase family; Region: Methyltransf_5; pfam01795 1279365010950 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1279365010951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1279365010952 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1279365010953 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1279365010954 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1279365010955 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1279365010956 hypothetical protein; Provisional; Region: PRK13688 1279365010957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365010958 Coenzyme A binding pocket [chemical binding]; other site 1279365010959 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1279365010960 putative active site [active] 1279365010961 catalytic site [active] 1279365010962 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1279365010963 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1279365010964 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1279365010965 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1279365010966 hypothetical protein; Provisional; Region: PRK13670 1279365010967 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1279365010968 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1279365010969 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1279365010970 protein binding site [polypeptide binding]; other site 1279365010971 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1279365010972 hypothetical protein; Provisional; Region: PRK10279 1279365010973 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1279365010974 active site 1279365010975 nucleophile elbow; other site 1279365010976 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1279365010977 Nucleoside recognition; Region: Gate; pfam07670 1279365010978 Nucleoside recognition; Region: Gate; pfam07670 1279365010979 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1279365010980 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1279365010981 active site 1279365010982 (T/H)XGH motif; other site 1279365010983 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1279365010984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365010985 S-adenosylmethionine binding site [chemical binding]; other site 1279365010986 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1279365010987 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1279365010988 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365010989 catalytic core [active] 1279365010990 YlbE-like protein; Region: YlbE; pfam14003 1279365010991 Putative coat protein; Region: YlbD_coat; pfam14071 1279365010992 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1279365010993 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1279365010994 YugN-like family; Region: YugN; pfam08868 1279365010995 formamidase; Provisional; Region: amiF; PRK13287 1279365010996 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1279365010997 multimer interface [polypeptide binding]; other site 1279365010998 active site 1279365010999 catalytic triad [active] 1279365011000 dimer interface [polypeptide binding]; other site 1279365011001 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1279365011002 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1279365011003 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1279365011004 Subunit I/III interface [polypeptide binding]; other site 1279365011005 Subunit III/IV interface [polypeptide binding]; other site 1279365011006 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1279365011007 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1279365011008 D-pathway; other site 1279365011009 Putative ubiquinol binding site [chemical binding]; other site 1279365011010 Low-spin heme (heme b) binding site [chemical binding]; other site 1279365011011 Putative water exit pathway; other site 1279365011012 Binuclear center (heme o3/CuB) [ion binding]; other site 1279365011013 K-pathway; other site 1279365011014 Putative proton exit pathway; other site 1279365011015 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1279365011016 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1279365011017 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1279365011018 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1279365011019 Cytochrome c; Region: Cytochrom_C; pfam00034 1279365011020 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1279365011021 UbiA prenyltransferase family; Region: UbiA; pfam01040 1279365011022 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1279365011023 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1279365011024 pyruvate carboxylase; Reviewed; Region: PRK12999 1279365011025 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1279365011026 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1279365011027 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1279365011028 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1279365011029 active site 1279365011030 catalytic residues [active] 1279365011031 metal binding site [ion binding]; metal-binding site 1279365011032 homodimer binding site [polypeptide binding]; other site 1279365011033 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1279365011034 carboxyltransferase (CT) interaction site; other site 1279365011035 biotinylation site [posttranslational modification]; other site 1279365011036 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1279365011037 hypothetical protein; Provisional; Region: PRK13666 1279365011038 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1279365011039 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1279365011040 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1279365011041 putative active site [active] 1279365011042 PhoH-like protein; Region: PhoH; pfam02562 1279365011043 hypothetical protein; Provisional; Region: PRK06733 1279365011044 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1279365011045 YlaH-like protein; Region: YlaH; pfam14036 1279365011046 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1279365011047 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1279365011048 G1 box; other site 1279365011049 putative GEF interaction site [polypeptide binding]; other site 1279365011050 GTP/Mg2+ binding site [chemical binding]; other site 1279365011051 Switch I region; other site 1279365011052 G2 box; other site 1279365011053 G3 box; other site 1279365011054 Switch II region; other site 1279365011055 G4 box; other site 1279365011056 G5 box; other site 1279365011057 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1279365011058 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1279365011059 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1279365011060 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1279365011061 active site 1279365011062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1279365011063 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1279365011064 hypothetical protein; Provisional; Region: PRK04387 1279365011065 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1279365011066 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1279365011067 homodimer interface [polypeptide binding]; other site 1279365011068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011069 catalytic residue [active] 1279365011070 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1279365011071 transglutaminase; Provisional; Region: tgl; PRK03187 1279365011072 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1279365011073 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1279365011074 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1279365011075 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 1279365011076 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1279365011077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365011078 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1279365011079 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1279365011080 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1279365011081 E3 interaction surface; other site 1279365011082 lipoyl attachment site [posttranslational modification]; other site 1279365011083 e3 binding domain; Region: E3_binding; pfam02817 1279365011084 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1279365011085 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1279365011086 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1279365011087 alpha subunit interface [polypeptide binding]; other site 1279365011088 TPP binding site [chemical binding]; other site 1279365011089 heterodimer interface [polypeptide binding]; other site 1279365011090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365011091 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1279365011092 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1279365011093 TPP-binding site [chemical binding]; other site 1279365011094 heterodimer interface [polypeptide binding]; other site 1279365011095 tetramer interface [polypeptide binding]; other site 1279365011096 phosphorylation loop region [posttranslational modification] 1279365011097 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1279365011098 active site 1279365011099 catalytic residues [active] 1279365011100 metal binding site [ion binding]; metal-binding site 1279365011101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365011102 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365011103 active site 1279365011104 motif I; other site 1279365011105 motif II; other site 1279365011106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365011107 hypothetical protein; Provisional; Region: PRK13667 1279365011108 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1279365011109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365011110 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1279365011111 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1279365011112 TrkA-N domain; Region: TrkA_N; pfam02254 1279365011113 TrkA-C domain; Region: TrkA_C; pfam02080 1279365011114 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1279365011115 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1279365011116 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1279365011117 metal binding site [ion binding]; metal-binding site 1279365011118 putative dimer interface [polypeptide binding]; other site 1279365011119 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1279365011120 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1279365011121 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1279365011122 trimer interface [polypeptide binding]; other site 1279365011123 active site 1279365011124 substrate binding site [chemical binding]; other site 1279365011125 CoA binding site [chemical binding]; other site 1279365011126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365011127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365011128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365011129 dimerization interface [polypeptide binding]; other site 1279365011130 FOG: CBS domain [General function prediction only]; Region: COG0517 1279365011131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1279365011132 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1279365011133 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1279365011134 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1279365011135 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1279365011136 catalytic residues [active] 1279365011137 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 1279365011138 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365011139 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1279365011140 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1279365011141 short chain dehydrogenase; Provisional; Region: PRK07677 1279365011142 NAD(P) binding site [chemical binding]; other site 1279365011143 substrate binding site [chemical binding]; other site 1279365011144 homotetramer interface [polypeptide binding]; other site 1279365011145 active site 1279365011146 homodimer interface [polypeptide binding]; other site 1279365011147 phosphodiesterase YaeI; Provisional; Region: PRK11340 1279365011148 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1279365011149 putative active site [active] 1279365011150 putative metal binding site [ion binding]; other site 1279365011151 polyphosphate kinase; Provisional; Region: PRK05443 1279365011152 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1279365011153 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1279365011154 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1279365011155 putative domain interface [polypeptide binding]; other site 1279365011156 putative active site [active] 1279365011157 catalytic site [active] 1279365011158 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1279365011159 putative domain interface [polypeptide binding]; other site 1279365011160 putative active site [active] 1279365011161 catalytic site [active] 1279365011162 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1279365011163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1279365011164 nucleotide binding site [chemical binding]; other site 1279365011165 YkyB-like protein; Region: YkyB; pfam14177 1279365011166 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1279365011167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365011168 I-site; other site 1279365011169 active site 1279365011170 metal binding site [ion binding]; metal-binding site 1279365011171 Phage lysis protein, holin; Region: Phage_holin; cl04675 1279365011172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365011173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365011174 putative substrate translocation pore; other site 1279365011175 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365011176 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1279365011177 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1279365011178 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1279365011179 THF binding site; other site 1279365011180 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1279365011181 substrate binding site [chemical binding]; other site 1279365011182 THF binding site; other site 1279365011183 zinc-binding site [ion binding]; other site 1279365011184 Competence protein J (ComJ); Region: ComJ; pfam11033 1279365011185 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1279365011186 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 1279365011187 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1279365011188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365011189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365011190 dimer interface [polypeptide binding]; other site 1279365011191 phosphorylation site [posttranslational modification] 1279365011192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365011193 ATP binding site [chemical binding]; other site 1279365011194 Mg2+ binding site [ion binding]; other site 1279365011195 G-X-G motif; other site 1279365011196 aminotransferase A; Validated; Region: PRK07683 1279365011197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365011198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011199 homodimer interface [polypeptide binding]; other site 1279365011200 catalytic residue [active] 1279365011201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365011202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365011203 DNA binding site [nucleotide binding] 1279365011204 domain linker motif; other site 1279365011205 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1279365011206 putative dimerization interface [polypeptide binding]; other site 1279365011207 putative ligand binding site [chemical binding]; other site 1279365011208 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1279365011209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365011210 dimer interface [polypeptide binding]; other site 1279365011211 conserved gate region; other site 1279365011212 putative PBP binding loops; other site 1279365011213 ABC-ATPase subunit interface; other site 1279365011214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365011215 dimer interface [polypeptide binding]; other site 1279365011216 conserved gate region; other site 1279365011217 putative PBP binding loops; other site 1279365011218 ABC-ATPase subunit interface; other site 1279365011219 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1279365011220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1279365011221 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1279365011222 homodimer interface [polypeptide binding]; other site 1279365011223 maltodextrin glucosidase; Provisional; Region: PRK10785 1279365011224 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1279365011225 active site 1279365011226 homodimer interface [polypeptide binding]; other site 1279365011227 catalytic site [active] 1279365011228 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1279365011229 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1279365011230 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1279365011231 Ca binding site [ion binding]; other site 1279365011232 active site 1279365011233 catalytic site [active] 1279365011234 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1279365011235 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1279365011236 Walker A/P-loop; other site 1279365011237 ATP binding site [chemical binding]; other site 1279365011238 Q-loop/lid; other site 1279365011239 ABC transporter signature motif; other site 1279365011240 Walker B; other site 1279365011241 D-loop; other site 1279365011242 H-loop/switch region; other site 1279365011243 TOBE domain; Region: TOBE_2; pfam08402 1279365011244 hypothetical protein; Provisional; Region: PRK06720 1279365011245 NAD(P) binding site [chemical binding]; other site 1279365011246 RDD family; Region: RDD; pfam06271 1279365011247 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 1279365011248 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1279365011249 Predicted ATPase [General function prediction only]; Region: COG3910 1279365011250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365011251 Walker A/P-loop; other site 1279365011252 ATP binding site [chemical binding]; other site 1279365011253 Q-loop/lid; other site 1279365011254 ABC transporter signature motif; other site 1279365011255 Walker B; other site 1279365011256 D-loop; other site 1279365011257 H-loop/switch region; other site 1279365011258 putative acyltransferase; Provisional; Region: PRK05790 1279365011259 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1279365011260 dimer interface [polypeptide binding]; other site 1279365011261 active site 1279365011262 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1279365011263 nudix motif; other site 1279365011264 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 1279365011265 hypothetical protein; Validated; Region: PRK07668 1279365011266 hypothetical protein; Validated; Region: PRK07668 1279365011267 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365011268 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365011269 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1279365011270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365011271 NAD(P) binding site [chemical binding]; other site 1279365011272 active site 1279365011273 YvrJ protein family; Region: YvrJ; pfam12841 1279365011274 Helix-turn-helix domain; Region: HTH_17; cl17695 1279365011275 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1279365011276 active site 1279365011277 Int/Topo IB signature motif; other site 1279365011278 DNA binding site [nucleotide binding] 1279365011279 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365011280 active site 1279365011281 catalytic residues [active] 1279365011282 DNA binding site [nucleotide binding] 1279365011283 Int/Topo IB signature motif; other site 1279365011284 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365011285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365011286 dimerization interface [polypeptide binding]; other site 1279365011287 putative DNA binding site [nucleotide binding]; other site 1279365011288 putative Zn2+ binding site [ion binding]; other site 1279365011289 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 1279365011290 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1279365011291 tetrameric interface [polypeptide binding]; other site 1279365011292 activator binding site; other site 1279365011293 NADP binding site [chemical binding]; other site 1279365011294 substrate binding site [chemical binding]; other site 1279365011295 catalytic residues [active] 1279365011296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365011297 dimerization interface [polypeptide binding]; other site 1279365011298 putative DNA binding site [nucleotide binding]; other site 1279365011299 putative Zn2+ binding site [ion binding]; other site 1279365011300 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1279365011301 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1279365011302 putative active site [active] 1279365011303 putative FMN binding site [chemical binding]; other site 1279365011304 putative substrate binding site [chemical binding]; other site 1279365011305 putative catalytic residue [active] 1279365011306 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1279365011307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365011308 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1279365011309 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1279365011310 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365011311 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1279365011312 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1279365011313 putative active site [active] 1279365011314 catalytic triad [active] 1279365011315 putative dimer interface [polypeptide binding]; other site 1279365011316 transaminase; Reviewed; Region: PRK08068 1279365011317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365011318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011319 homodimer interface [polypeptide binding]; other site 1279365011320 catalytic residue [active] 1279365011321 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1279365011322 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1279365011323 dimer interface [polypeptide binding]; other site 1279365011324 active site 1279365011325 catalytic residue [active] 1279365011326 metal binding site [ion binding]; metal-binding site 1279365011327 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 1279365011328 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1279365011329 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1279365011330 intersubunit interface [polypeptide binding]; other site 1279365011331 active site 1279365011332 Zn2+ binding site [ion binding]; other site 1279365011333 ARD/ARD' family; Region: ARD; pfam03079 1279365011334 Cupin domain; Region: Cupin_2; pfam07883 1279365011335 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 1279365011336 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1279365011337 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1279365011338 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1279365011339 Beta-lactamase; Region: Beta-lactamase; pfam00144 1279365011340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365011341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365011342 metal binding site [ion binding]; metal-binding site 1279365011343 active site 1279365011344 I-site; other site 1279365011345 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1279365011346 dimer interface [polypeptide binding]; other site 1279365011347 FMN binding site [chemical binding]; other site 1279365011348 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 1279365011349 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1279365011350 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1279365011351 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1279365011352 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1279365011353 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1279365011354 dimerization domain swap beta strand [polypeptide binding]; other site 1279365011355 regulatory protein interface [polypeptide binding]; other site 1279365011356 active site 1279365011357 regulatory phosphorylation site [posttranslational modification]; other site 1279365011358 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1279365011359 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1279365011360 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1279365011361 active site turn [active] 1279365011362 phosphorylation site [posttranslational modification] 1279365011363 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1279365011364 HPr interaction site; other site 1279365011365 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1279365011366 active site 1279365011367 phosphorylation site [posttranslational modification] 1279365011368 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1279365011369 CAT RNA binding domain; Region: CAT_RBD; smart01061 1279365011370 PRD domain; Region: PRD; pfam00874 1279365011371 PRD domain; Region: PRD; pfam00874 1279365011372 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365011373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365011374 active site 1279365011375 motif I; other site 1279365011376 motif II; other site 1279365011377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365011378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1279365011379 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1279365011380 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1279365011381 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1279365011382 active site 1279365011383 trimer interface [polypeptide binding]; other site 1279365011384 allosteric site; other site 1279365011385 active site lid [active] 1279365011386 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1279365011387 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1279365011388 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1279365011389 active site 1279365011390 dimer interface [polypeptide binding]; other site 1279365011391 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1279365011392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365011393 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1279365011394 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1279365011395 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1279365011396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365011397 Coenzyme A binding pocket [chemical binding]; other site 1279365011398 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1279365011399 active site 1279365011400 Predicted secreted protein [Function unknown]; Region: COG4086 1279365011401 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1279365011402 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365011403 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1279365011404 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1279365011405 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365011406 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1279365011407 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1279365011408 stage V sporulation protein AD; Validated; Region: PRK08304 1279365011409 stage V sporulation protein AD; Provisional; Region: PRK12404 1279365011410 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1279365011411 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1279365011412 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1279365011413 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1279365011414 putative substrate binding site 2 [chemical binding]; other site 1279365011415 putative substrate binding site 1 [chemical binding]; other site 1279365011416 Na binding site 1 [ion binding]; other site 1279365011417 Na2 binding site [ion binding]; other site 1279365011418 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1279365011419 sporulation sigma factor SigF; Validated; Region: PRK05572 1279365011420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365011421 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1279365011422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365011423 DNA binding residues [nucleotide binding] 1279365011424 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1279365011425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365011426 ATP binding site [chemical binding]; other site 1279365011427 Mg2+ binding site [ion binding]; other site 1279365011428 G-X-G motif; other site 1279365011429 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1279365011430 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1279365011431 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365011432 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1279365011433 Predicted transcriptional regulators [Transcription]; Region: COG1725 1279365011434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365011435 DNA-binding site [nucleotide binding]; DNA binding site 1279365011436 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365011437 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365011438 Walker A/P-loop; other site 1279365011439 ATP binding site [chemical binding]; other site 1279365011440 Q-loop/lid; other site 1279365011441 ABC transporter signature motif; other site 1279365011442 Walker B; other site 1279365011443 D-loop; other site 1279365011444 H-loop/switch region; other site 1279365011445 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1279365011446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365011447 MarR family; Region: MarR; pfam01047 1279365011448 MarR family; Region: MarR_2; cl17246 1279365011449 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1279365011450 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1279365011451 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1279365011452 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1279365011453 oligomer interface [polypeptide binding]; other site 1279365011454 metal binding site [ion binding]; metal-binding site 1279365011455 metal binding site [ion binding]; metal-binding site 1279365011456 putative Cl binding site [ion binding]; other site 1279365011457 aspartate ring; other site 1279365011458 basic sphincter; other site 1279365011459 hydrophobic gate; other site 1279365011460 periplasmic entrance; other site 1279365011461 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1279365011462 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1279365011463 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1279365011464 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1279365011465 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1279365011466 phosphopentomutase; Provisional; Region: PRK05362 1279365011467 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1279365011468 YtkA-like; Region: YtkA; pfam13115 1279365011469 YtkA-like; Region: YtkA; pfam13115 1279365011470 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1279365011471 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1279365011472 active site 1279365011473 Int/Topo IB signature motif; other site 1279365011474 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1279365011475 ferric uptake regulator; Provisional; Region: fur; PRK09462 1279365011476 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1279365011477 metal binding site 2 [ion binding]; metal-binding site 1279365011478 putative DNA binding helix; other site 1279365011479 metal binding site 1 [ion binding]; metal-binding site 1279365011480 dimer interface [polypeptide binding]; other site 1279365011481 structural Zn2+ binding site [ion binding]; other site 1279365011482 Integral membrane protein DUF95; Region: DUF95; cl00572 1279365011483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365011484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365011485 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1279365011486 dimer interface [polypeptide binding]; other site 1279365011487 ADP-ribose binding site [chemical binding]; other site 1279365011488 active site 1279365011489 nudix motif; other site 1279365011490 metal binding site [ion binding]; metal-binding site 1279365011491 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1279365011492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365011493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365011494 active site 1279365011495 catalytic tetrad [active] 1279365011496 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365011497 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365011498 active site 1279365011499 catalytic tetrad [active] 1279365011500 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1279365011501 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 1279365011502 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1279365011503 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1279365011504 putative active site [active] 1279365011505 putative metal binding site [ion binding]; other site 1279365011506 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1279365011507 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1279365011508 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365011509 Predicted permease [General function prediction only]; Region: COG2056 1279365011510 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1279365011511 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1279365011512 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365011513 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365011514 DNA binding site [nucleotide binding] 1279365011515 domain linker motif; other site 1279365011516 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1279365011517 dimerization interface [polypeptide binding]; other site 1279365011518 ligand binding site [chemical binding]; other site 1279365011519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365011520 Coenzyme A binding pocket [chemical binding]; other site 1279365011521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365011522 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1279365011523 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1279365011524 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1279365011525 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1279365011526 catalytic motif [active] 1279365011527 Zn binding site [ion binding]; other site 1279365011528 RibD C-terminal domain; Region: RibD_C; cl17279 1279365011529 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1279365011530 Lumazine binding domain; Region: Lum_binding; pfam00677 1279365011531 Lumazine binding domain; Region: Lum_binding; pfam00677 1279365011532 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1279365011533 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1279365011534 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1279365011535 dimerization interface [polypeptide binding]; other site 1279365011536 active site 1279365011537 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1279365011538 homopentamer interface [polypeptide binding]; other site 1279365011539 active site 1279365011540 biotin synthase; Validated; Region: PRK06256 1279365011541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365011542 FeS/SAM binding site; other site 1279365011543 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1279365011544 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1279365011545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365011546 S-adenosylmethionine binding site [chemical binding]; other site 1279365011547 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1279365011548 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1279365011549 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1279365011550 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1279365011551 substrate-cofactor binding pocket; other site 1279365011552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011553 catalytic residue [active] 1279365011554 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1279365011555 AAA domain; Region: AAA_26; pfam13500 1279365011556 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1279365011557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365011558 inhibitor-cofactor binding pocket; inhibition site 1279365011559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011560 catalytic residue [active] 1279365011561 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1279365011562 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1279365011563 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 1279365011564 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1279365011565 active site 1279365011566 metal binding site [ion binding]; metal-binding site 1279365011567 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1279365011568 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1279365011569 active site 1279365011570 catalytic triad [active] 1279365011571 oxyanion hole [active] 1279365011572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365011573 dimerization interface [polypeptide binding]; other site 1279365011574 putative DNA binding site [nucleotide binding]; other site 1279365011575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365011576 putative Zn2+ binding site [ion binding]; other site 1279365011577 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1279365011578 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1279365011579 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1279365011580 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1279365011581 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1279365011582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365011583 inhibitor-cofactor binding pocket; inhibition site 1279365011584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011585 catalytic residue [active] 1279365011586 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1279365011587 nucleotide binding site [chemical binding]; other site 1279365011588 N-acetyl-L-glutamate binding site [chemical binding]; other site 1279365011589 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1279365011590 heterotetramer interface [polypeptide binding]; other site 1279365011591 active site pocket [active] 1279365011592 cleavage site 1279365011593 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1279365011594 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1279365011595 YqzH-like protein; Region: YqzH; pfam14164 1279365011596 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1279365011597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365011598 NAD(P) binding site [chemical binding]; other site 1279365011599 active site 1279365011600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365011601 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 1279365011602 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1279365011603 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1279365011604 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1279365011605 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1279365011606 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1279365011607 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1279365011608 putative L-serine binding site [chemical binding]; other site 1279365011609 ribonuclease Z; Region: RNase_Z; TIGR02651 1279365011610 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 1279365011611 magnesium-transporting ATPase; Provisional; Region: PRK15122 1279365011612 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1279365011613 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1279365011614 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1279365011615 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1279365011616 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1279365011617 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1279365011618 MgtC family; Region: MgtC; pfam02308 1279365011619 DNA polymerase IV; Validated; Region: PRK01810 1279365011620 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1279365011621 active site 1279365011622 DNA binding site [nucleotide binding] 1279365011623 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1279365011624 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1279365011625 peptidase T-like protein; Region: PepT-like; TIGR01883 1279365011626 metal binding site [ion binding]; metal-binding site 1279365011627 putative dimer interface [polypeptide binding]; other site 1279365011628 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365011629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365011630 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 1279365011631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1279365011632 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1279365011633 Predicted membrane protein [Function unknown]; Region: COG4129 1279365011634 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1279365011635 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1279365011636 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1279365011637 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1279365011638 Walker A/P-loop; other site 1279365011639 ATP binding site [chemical binding]; other site 1279365011640 Q-loop/lid; other site 1279365011641 ABC transporter signature motif; other site 1279365011642 Walker B; other site 1279365011643 D-loop; other site 1279365011644 H-loop/switch region; other site 1279365011645 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1279365011646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365011647 dimer interface [polypeptide binding]; other site 1279365011648 conserved gate region; other site 1279365011649 putative PBP binding loops; other site 1279365011650 ABC-ATPase subunit interface; other site 1279365011651 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1279365011652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1279365011653 substrate binding pocket [chemical binding]; other site 1279365011654 membrane-bound complex binding site; other site 1279365011655 hinge residues; other site 1279365011656 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1279365011657 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1279365011658 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1279365011659 nudix motif; other site 1279365011660 Predicted membrane protein [Function unknown]; Region: COG2323 1279365011661 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1279365011662 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1279365011663 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1279365011664 E3 interaction surface; other site 1279365011665 lipoyl attachment site [posttranslational modification]; other site 1279365011666 e3 binding domain; Region: E3_binding; pfam02817 1279365011667 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1279365011668 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1279365011669 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1279365011670 alpha subunit interface [polypeptide binding]; other site 1279365011671 TPP binding site [chemical binding]; other site 1279365011672 heterodimer interface [polypeptide binding]; other site 1279365011673 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365011674 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1279365011675 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1279365011676 tetramer interface [polypeptide binding]; other site 1279365011677 TPP-binding site [chemical binding]; other site 1279365011678 heterodimer interface [polypeptide binding]; other site 1279365011679 phosphorylation loop region [posttranslational modification] 1279365011680 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1279365011681 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1279365011682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365011683 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1279365011684 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1279365011685 nucleotide binding site [chemical binding]; other site 1279365011686 Acetokinase family; Region: Acetate_kinase; cl17229 1279365011687 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1279365011688 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1279365011689 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1279365011690 NAD binding site [chemical binding]; other site 1279365011691 Phe binding site; other site 1279365011692 phosphate butyryltransferase; Validated; Region: PRK07742 1279365011693 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1279365011694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365011695 putative active site [active] 1279365011696 heme pocket [chemical binding]; other site 1279365011697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365011698 putative active site [active] 1279365011699 heme pocket [chemical binding]; other site 1279365011700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365011701 Walker A motif; other site 1279365011702 ATP binding site [chemical binding]; other site 1279365011703 Walker B motif; other site 1279365011704 arginine finger; other site 1279365011705 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1279365011706 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1279365011707 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1279365011708 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1279365011709 active site 1279365011710 catalytic site [active] 1279365011711 metal binding site [ion binding]; metal-binding site 1279365011712 dimer interface [polypeptide binding]; other site 1279365011713 YycC-like protein; Region: YycC; pfam14174 1279365011714 hypothetical protein; Provisional; Region: PRK06770 1279365011715 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1279365011716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365011717 active site 1279365011718 phosphorylation site [posttranslational modification] 1279365011719 intermolecular recognition site; other site 1279365011720 dimerization interface [polypeptide binding]; other site 1279365011721 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1279365011722 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1279365011723 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1279365011724 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1279365011725 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1279365011726 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1279365011727 Walker A/P-loop; other site 1279365011728 ATP binding site [chemical binding]; other site 1279365011729 Q-loop/lid; other site 1279365011730 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1279365011731 ABC transporter signature motif; other site 1279365011732 Walker B; other site 1279365011733 D-loop; other site 1279365011734 H-loop/switch region; other site 1279365011735 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1279365011736 arginine repressor; Provisional; Region: PRK04280 1279365011737 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1279365011738 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1279365011739 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365011740 RNA binding surface [nucleotide binding]; other site 1279365011741 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1279365011742 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1279365011743 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1279365011744 TPP-binding site; other site 1279365011745 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1279365011746 PYR/PP interface [polypeptide binding]; other site 1279365011747 dimer interface [polypeptide binding]; other site 1279365011748 TPP binding site [chemical binding]; other site 1279365011749 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1279365011750 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1279365011751 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1279365011752 substrate binding pocket [chemical binding]; other site 1279365011753 chain length determination region; other site 1279365011754 substrate-Mg2+ binding site; other site 1279365011755 catalytic residues [active] 1279365011756 aspartate-rich region 1; other site 1279365011757 active site lid residues [active] 1279365011758 aspartate-rich region 2; other site 1279365011759 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1279365011760 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1279365011761 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1279365011762 generic binding surface II; other site 1279365011763 generic binding surface I; other site 1279365011764 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1279365011765 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1279365011766 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1279365011767 homodimer interface [polypeptide binding]; other site 1279365011768 NADP binding site [chemical binding]; other site 1279365011769 substrate binding site [chemical binding]; other site 1279365011770 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1279365011771 putative RNA binding site [nucleotide binding]; other site 1279365011772 Asp23 family; Region: Asp23; pfam03780 1279365011773 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1279365011774 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1279365011775 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1279365011776 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1279365011777 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1279365011778 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1279365011779 carboxyltransferase (CT) interaction site; other site 1279365011780 biotinylation site [posttranslational modification]; other site 1279365011781 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1279365011782 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1279365011783 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1279365011784 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1279365011785 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1279365011786 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1279365011787 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1279365011788 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1279365011789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365011790 Walker A motif; other site 1279365011791 ATP binding site [chemical binding]; other site 1279365011792 Walker B motif; other site 1279365011793 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1279365011794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365011795 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365011796 elongation factor P; Validated; Region: PRK00529 1279365011797 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1279365011798 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1279365011799 RNA binding site [nucleotide binding]; other site 1279365011800 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1279365011801 RNA binding site [nucleotide binding]; other site 1279365011802 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1279365011803 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1279365011804 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1279365011805 active site 1279365011806 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1279365011807 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1279365011808 trimer interface [polypeptide binding]; other site 1279365011809 active site 1279365011810 dimer interface [polypeptide binding]; other site 1279365011811 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1279365011812 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1279365011813 Carbon starvation protein CstA; Region: CstA; pfam02554 1279365011814 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1279365011815 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1279365011816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365011817 motif II; other site 1279365011818 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1279365011819 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1279365011820 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1279365011821 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1279365011822 Predicted transcriptional regulators [Transcription]; Region: COG1695 1279365011823 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1279365011824 hypothetical protein; Validated; Region: PRK07668 1279365011825 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1279365011826 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365011827 active site residue [active] 1279365011828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365011829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365011830 DNA binding site [nucleotide binding] 1279365011831 domain linker motif; other site 1279365011832 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1279365011833 putative dimerization interface [polypeptide binding]; other site 1279365011834 putative ligand binding site [chemical binding]; other site 1279365011835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365011836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365011837 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1279365011838 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1279365011839 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 1279365011840 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1279365011841 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1279365011842 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1279365011843 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1279365011844 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365011845 Walker A/P-loop; other site 1279365011846 ATP binding site [chemical binding]; other site 1279365011847 Q-loop/lid; other site 1279365011848 ABC transporter signature motif; other site 1279365011849 Walker B; other site 1279365011850 D-loop; other site 1279365011851 H-loop/switch region; other site 1279365011852 Predicted transcriptional regulators [Transcription]; Region: COG1725 1279365011853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365011854 DNA-binding site [nucleotide binding]; DNA binding site 1279365011855 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 1279365011856 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1279365011857 tetramer interface [polypeptide binding]; other site 1279365011858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011859 catalytic residue [active] 1279365011860 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1279365011861 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1279365011862 tetramer interface [polypeptide binding]; other site 1279365011863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011864 catalytic residue [active] 1279365011865 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1279365011866 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1279365011867 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1279365011868 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1279365011869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365011870 ATP binding site [chemical binding]; other site 1279365011871 putative Mg++ binding site [ion binding]; other site 1279365011872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365011873 nucleotide binding region [chemical binding]; other site 1279365011874 ATP-binding site [chemical binding]; other site 1279365011875 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1279365011876 YqzE-like protein; Region: YqzE; pfam14038 1279365011877 Shikimate kinase; Region: SKI; pfam01202 1279365011878 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1279365011879 ADP binding site [chemical binding]; other site 1279365011880 magnesium binding site [ion binding]; other site 1279365011881 putative shikimate binding site; other site 1279365011882 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1279365011883 ComG operon protein 7; Region: ComGG; pfam14173 1279365011884 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1279365011885 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1279365011886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1279365011887 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1279365011888 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1279365011889 Type II/IV secretion system protein; Region: T2SE; pfam00437 1279365011890 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365011891 Walker A motif; other site 1279365011892 ATP binding site [chemical binding]; other site 1279365011893 Walker B motif; other site 1279365011894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365011895 putative DNA binding site [nucleotide binding]; other site 1279365011896 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1279365011897 putative Zn2+ binding site [ion binding]; other site 1279365011898 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1279365011899 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1279365011900 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1279365011901 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 1279365011902 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1279365011903 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1279365011904 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1279365011905 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 1279365011906 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1279365011907 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1279365011908 active site 1279365011909 homodimer interface [polypeptide binding]; other site 1279365011910 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1279365011911 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1279365011912 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1279365011913 substrate binding pocket [chemical binding]; other site 1279365011914 dimer interface [polypeptide binding]; other site 1279365011915 inhibitor binding site; inhibition site 1279365011916 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1279365011917 B12 binding site [chemical binding]; other site 1279365011918 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1279365011919 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1279365011920 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1279365011921 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1279365011922 FAD binding site [chemical binding]; other site 1279365011923 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1279365011924 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1279365011925 homodimer interface [polypeptide binding]; other site 1279365011926 substrate-cofactor binding pocket; other site 1279365011927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011928 catalytic residue [active] 1279365011929 cystathionine beta-lyase; Provisional; Region: PRK08064 1279365011930 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1279365011931 homodimer interface [polypeptide binding]; other site 1279365011932 substrate-cofactor binding pocket; other site 1279365011933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365011934 catalytic residue [active] 1279365011935 Isochorismatase family; Region: Isochorismatase; pfam00857 1279365011936 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1279365011937 catalytic triad [active] 1279365011938 conserved cis-peptide bond; other site 1279365011939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365011940 dimerization interface [polypeptide binding]; other site 1279365011941 putative DNA binding site [nucleotide binding]; other site 1279365011942 putative Zn2+ binding site [ion binding]; other site 1279365011943 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1279365011944 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1279365011945 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1279365011946 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1279365011947 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1279365011948 nucleotide binding site [chemical binding]; other site 1279365011949 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1279365011950 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1279365011951 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1279365011952 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1279365011953 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1279365011954 active site 1279365011955 metal binding site [ion binding]; metal-binding site 1279365011956 substrate binding site [chemical binding]; other site 1279365011957 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1279365011958 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1279365011959 active site 1279365011960 Substrate binding site; other site 1279365011961 Mg++ binding site; other site 1279365011962 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 1279365011963 putative CoA binding site [chemical binding]; other site 1279365011964 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1279365011965 putative trimer interface [polypeptide binding]; other site 1279365011966 putative CoA binding site [chemical binding]; other site 1279365011967 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1279365011968 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1279365011969 PhoU domain; Region: PhoU; pfam01895 1279365011970 PhoU domain; Region: PhoU; pfam01895 1279365011971 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1279365011972 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1279365011973 Walker A/P-loop; other site 1279365011974 ATP binding site [chemical binding]; other site 1279365011975 Q-loop/lid; other site 1279365011976 ABC transporter signature motif; other site 1279365011977 Walker B; other site 1279365011978 D-loop; other site 1279365011979 H-loop/switch region; other site 1279365011980 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1279365011981 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1279365011982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365011983 dimer interface [polypeptide binding]; other site 1279365011984 conserved gate region; other site 1279365011985 putative PBP binding loops; other site 1279365011986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1279365011987 ABC-ATPase subunit interface; other site 1279365011988 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1279365011989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365011990 dimer interface [polypeptide binding]; other site 1279365011991 conserved gate region; other site 1279365011992 putative PBP binding loops; other site 1279365011993 ABC-ATPase subunit interface; other site 1279365011994 PBP superfamily domain; Region: PBP_like_2; cl17296 1279365011995 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365011996 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365011997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365011998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365011999 putative substrate translocation pore; other site 1279365012000 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365012001 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1279365012002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1279365012003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1279365012004 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1279365012005 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1279365012006 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1279365012007 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1279365012008 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1279365012009 metal binding site 2 [ion binding]; metal-binding site 1279365012010 putative DNA binding helix; other site 1279365012011 metal binding site 1 [ion binding]; metal-binding site 1279365012012 dimer interface [polypeptide binding]; other site 1279365012013 structural Zn2+ binding site [ion binding]; other site 1279365012014 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1279365012015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365012016 ABC-ATPase subunit interface; other site 1279365012017 dimer interface [polypeptide binding]; other site 1279365012018 putative PBP binding regions; other site 1279365012019 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1279365012020 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1279365012021 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365012022 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365012023 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365012024 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1279365012025 endonuclease IV; Provisional; Region: PRK01060 1279365012026 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1279365012027 AP (apurinic/apyrimidinic) site pocket; other site 1279365012028 DNA interaction; other site 1279365012029 Metal-binding active site; metal-binding site 1279365012030 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1279365012031 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1279365012032 ATP binding site [chemical binding]; other site 1279365012033 Mg++ binding site [ion binding]; other site 1279365012034 motif III; other site 1279365012035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365012036 nucleotide binding region [chemical binding]; other site 1279365012037 ATP-binding site [chemical binding]; other site 1279365012038 YqfQ-like protein; Region: YqfQ; pfam14181 1279365012039 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1279365012040 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1279365012041 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1279365012042 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1279365012043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1279365012044 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1279365012045 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1279365012046 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1279365012047 Family of unknown function (DUF633); Region: DUF633; pfam04816 1279365012048 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1279365012049 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1279365012050 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1279365012051 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1279365012052 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1279365012053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365012054 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1279365012055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365012056 DNA binding residues [nucleotide binding] 1279365012057 DNA primase; Validated; Region: dnaG; PRK05667 1279365012058 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1279365012059 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1279365012060 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1279365012061 active site 1279365012062 metal binding site [ion binding]; metal-binding site 1279365012063 interdomain interaction site; other site 1279365012064 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1279365012065 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1279365012066 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1279365012067 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1279365012068 HTH domain; Region: HTH_11; pfam08279 1279365012069 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1279365012070 FOG: CBS domain [General function prediction only]; Region: COG0517 1279365012071 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1279365012072 Recombination protein O N terminal; Region: RecO_N; pfam11967 1279365012073 Recombination protein O C terminal; Region: RecO_C; pfam02565 1279365012074 YqzL-like protein; Region: YqzL; pfam14006 1279365012075 GTPase Era; Reviewed; Region: era; PRK00089 1279365012076 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1279365012077 G1 box; other site 1279365012078 GTP/Mg2+ binding site [chemical binding]; other site 1279365012079 Switch I region; other site 1279365012080 G2 box; other site 1279365012081 Switch II region; other site 1279365012082 G3 box; other site 1279365012083 G4 box; other site 1279365012084 G5 box; other site 1279365012085 KH domain; Region: KH_2; pfam07650 1279365012086 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1279365012087 active site 1279365012088 catalytic motif [active] 1279365012089 Zn binding site [ion binding]; other site 1279365012090 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1279365012091 metal-binding heat shock protein; Provisional; Region: PRK00016 1279365012092 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1279365012093 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1279365012094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365012095 Zn2+ binding site [ion binding]; other site 1279365012096 Mg2+ binding site [ion binding]; other site 1279365012097 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1279365012098 PhoH-like protein; Region: PhoH; pfam02562 1279365012099 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1279365012100 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1279365012101 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1279365012102 Yqey-like protein; Region: YqeY; pfam09424 1279365012103 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1279365012104 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1279365012105 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1279365012106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365012107 FeS/SAM binding site; other site 1279365012108 TRAM domain; Region: TRAM; cl01282 1279365012109 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1279365012110 RNA methyltransferase, RsmE family; Region: TIGR00046 1279365012111 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1279365012112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365012113 S-adenosylmethionine binding site [chemical binding]; other site 1279365012114 chaperone protein DnaJ; Provisional; Region: PRK14280 1279365012115 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1279365012116 HSP70 interaction site [polypeptide binding]; other site 1279365012117 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1279365012118 substrate binding site [polypeptide binding]; other site 1279365012119 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1279365012120 Zn binding sites [ion binding]; other site 1279365012121 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1279365012122 dimer interface [polypeptide binding]; other site 1279365012123 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1279365012124 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1279365012125 nucleotide binding site [chemical binding]; other site 1279365012126 NEF interaction site [polypeptide binding]; other site 1279365012127 SBD interface [polypeptide binding]; other site 1279365012128 GrpE; Region: GrpE; pfam01025 1279365012129 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1279365012130 dimer interface [polypeptide binding]; other site 1279365012131 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1279365012132 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1279365012133 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1279365012134 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1279365012135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365012136 FeS/SAM binding site; other site 1279365012137 HemN C-terminal domain; Region: HemN_C; pfam06969 1279365012138 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365012139 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1279365012140 GTP-binding protein LepA; Provisional; Region: PRK05433 1279365012141 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1279365012142 G1 box; other site 1279365012143 putative GEF interaction site [polypeptide binding]; other site 1279365012144 GTP/Mg2+ binding site [chemical binding]; other site 1279365012145 Switch I region; other site 1279365012146 G2 box; other site 1279365012147 G3 box; other site 1279365012148 Switch II region; other site 1279365012149 G4 box; other site 1279365012150 G5 box; other site 1279365012151 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1279365012152 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1279365012153 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1279365012154 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1279365012155 germination protease; Provisional; Region: PRK02858 1279365012156 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1279365012157 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1279365012158 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1279365012159 YqzM-like protein; Region: YqzM; pfam14141 1279365012160 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1279365012161 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1279365012162 Competence protein; Region: Competence; pfam03772 1279365012163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365012164 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1279365012165 catalytic motif [active] 1279365012166 Zn binding site [ion binding]; other site 1279365012167 SLBB domain; Region: SLBB; pfam10531 1279365012168 comEA protein; Region: comE; TIGR01259 1279365012169 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1279365012170 late competence protein ComER; Validated; Region: PRK07680 1279365012171 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1279365012172 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1279365012173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365012174 S-adenosylmethionine binding site [chemical binding]; other site 1279365012175 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 1279365012176 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1279365012177 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365012178 Zn2+ binding site [ion binding]; other site 1279365012179 Mg2+ binding site [ion binding]; other site 1279365012180 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1279365012181 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1279365012182 active site 1279365012183 (T/H)XGH motif; other site 1279365012184 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1279365012185 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1279365012186 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1279365012187 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1279365012188 shikimate binding site; other site 1279365012189 NAD(P) binding site [chemical binding]; other site 1279365012190 GTPase YqeH; Provisional; Region: PRK13796 1279365012191 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1279365012192 GTP/Mg2+ binding site [chemical binding]; other site 1279365012193 G4 box; other site 1279365012194 G5 box; other site 1279365012195 G1 box; other site 1279365012196 Switch I region; other site 1279365012197 G2 box; other site 1279365012198 G3 box; other site 1279365012199 Switch II region; other site 1279365012200 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1279365012201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365012202 active site 1279365012203 motif I; other site 1279365012204 motif II; other site 1279365012205 Sporulation inhibitor A; Region: Sda; pfam08970 1279365012206 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1279365012207 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1279365012208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365012209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365012210 DNA binding residues [nucleotide binding] 1279365012211 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1279365012212 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1279365012213 dimer interface [polypeptide binding]; other site 1279365012214 FMN binding site [chemical binding]; other site 1279365012215 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1279365012216 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1279365012217 synthetase active site [active] 1279365012218 NTP binding site [chemical binding]; other site 1279365012219 metal binding site [ion binding]; metal-binding site 1279365012220 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1279365012221 dimer interface [polypeptide binding]; other site 1279365012222 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1279365012223 active site 1279365012224 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365012225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365012226 Coenzyme A binding pocket [chemical binding]; other site 1279365012227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365012228 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365012229 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1279365012230 catalytic site [active] 1279365012231 CHAT domain; Region: CHAT; cl17868 1279365012232 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1279365012233 catalytic core [active] 1279365012234 transposase/IS protein; Provisional; Region: PRK09183 1279365012235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012236 Walker A motif; other site 1279365012237 ATP binding site [chemical binding]; other site 1279365012238 Walker B motif; other site 1279365012239 arginine finger; other site 1279365012240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365012241 Integrase core domain; Region: rve; pfam00665 1279365012242 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 1279365012243 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1279365012244 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1279365012245 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1279365012246 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1279365012247 cofactor binding site; other site 1279365012248 metal binding site [ion binding]; metal-binding site 1279365012249 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1279365012250 aromatic arch; other site 1279365012251 DCoH dimer interaction site [polypeptide binding]; other site 1279365012252 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1279365012253 DCoH tetramer interaction site [polypeptide binding]; other site 1279365012254 substrate binding site [chemical binding]; other site 1279365012255 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1279365012256 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1279365012257 putative metal binding site [ion binding]; other site 1279365012258 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1279365012259 active site 1279365012260 Predicted membrane protein [Function unknown]; Region: COG2259 1279365012261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365012262 non-specific DNA binding site [nucleotide binding]; other site 1279365012263 salt bridge; other site 1279365012264 sequence-specific DNA binding site [nucleotide binding]; other site 1279365012265 Cupin domain; Region: Cupin_2; pfam07883 1279365012266 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1279365012267 active site 2 [active] 1279365012268 active site 1 [active] 1279365012269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365012270 Coenzyme A binding pocket [chemical binding]; other site 1279365012271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365012272 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365012273 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1279365012274 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1279365012275 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1279365012276 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1279365012277 Walker A/P-loop; other site 1279365012278 ATP binding site [chemical binding]; other site 1279365012279 Q-loop/lid; other site 1279365012280 ABC transporter signature motif; other site 1279365012281 Walker B; other site 1279365012282 D-loop; other site 1279365012283 H-loop/switch region; other site 1279365012284 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1279365012285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365012286 ABC-ATPase subunit interface; other site 1279365012287 dimer interface [polypeptide binding]; other site 1279365012288 putative PBP binding regions; other site 1279365012289 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365012290 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1279365012291 intersubunit interface [polypeptide binding]; other site 1279365012292 YrhC-like protein; Region: YrhC; pfam14143 1279365012293 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1279365012294 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1279365012295 putative catalytic cysteine [active] 1279365012296 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1279365012297 putative active site [active] 1279365012298 metal binding site [ion binding]; metal-binding site 1279365012299 cystathionine beta-lyase; Provisional; Region: PRK07671 1279365012300 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1279365012301 homodimer interface [polypeptide binding]; other site 1279365012302 substrate-cofactor binding pocket; other site 1279365012303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365012304 catalytic residue [active] 1279365012305 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1279365012306 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1279365012307 dimer interface [polypeptide binding]; other site 1279365012308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365012309 catalytic residue [active] 1279365012310 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1279365012311 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1279365012312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365012313 S-adenosylmethionine binding site [chemical binding]; other site 1279365012314 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1279365012315 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1279365012316 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1279365012317 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1279365012318 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365012319 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 1279365012320 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1279365012321 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1279365012322 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1279365012323 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1279365012324 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1279365012325 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1279365012326 Sugar specificity; other site 1279365012327 Pyrimidine base specificity; other site 1279365012328 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1279365012329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1279365012330 Peptidase family U32; Region: Peptidase_U32; pfam01136 1279365012331 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1279365012332 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1279365012333 Peptidase family U32; Region: Peptidase_U32; pfam01136 1279365012334 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1279365012335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365012336 S-adenosylmethionine binding site [chemical binding]; other site 1279365012337 YceG-like family; Region: YceG; pfam02618 1279365012338 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1279365012339 dimerization interface [polypeptide binding]; other site 1279365012340 hypothetical protein; Provisional; Region: PRK13678 1279365012341 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1279365012342 hypothetical protein; Provisional; Region: PRK05473 1279365012343 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1279365012344 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1279365012345 motif 1; other site 1279365012346 active site 1279365012347 motif 2; other site 1279365012348 motif 3; other site 1279365012349 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1279365012350 DHHA1 domain; Region: DHHA1; pfam02272 1279365012351 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1279365012352 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1279365012353 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1279365012354 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1279365012355 AAA domain; Region: AAA_30; pfam13604 1279365012356 Family description; Region: UvrD_C_2; pfam13538 1279365012357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365012358 TPR motif; other site 1279365012359 TPR repeat; Region: TPR_11; pfam13414 1279365012360 binding surface 1279365012361 TPR repeat; Region: TPR_11; pfam13414 1279365012362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365012363 binding surface 1279365012364 TPR motif; other site 1279365012365 TPR repeat; Region: TPR_11; pfam13414 1279365012366 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1279365012367 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1279365012368 Ligand Binding Site [chemical binding]; other site 1279365012369 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1279365012370 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1279365012371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365012372 catalytic residue [active] 1279365012373 Predicted transcriptional regulator [Transcription]; Region: COG1959 1279365012374 Transcriptional regulator; Region: Rrf2; pfam02082 1279365012375 recombination factor protein RarA; Reviewed; Region: PRK13342 1279365012376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012377 Walker A motif; other site 1279365012378 ATP binding site [chemical binding]; other site 1279365012379 Walker B motif; other site 1279365012380 arginine finger; other site 1279365012381 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1279365012382 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1279365012383 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1279365012384 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1279365012385 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1279365012386 putative ATP binding site [chemical binding]; other site 1279365012387 putative substrate interface [chemical binding]; other site 1279365012388 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1279365012389 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1279365012390 dimer interface [polypeptide binding]; other site 1279365012391 anticodon binding site; other site 1279365012392 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1279365012393 homodimer interface [polypeptide binding]; other site 1279365012394 motif 1; other site 1279365012395 active site 1279365012396 motif 2; other site 1279365012397 GAD domain; Region: GAD; pfam02938 1279365012398 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1279365012399 motif 3; other site 1279365012400 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1279365012401 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1279365012402 dimer interface [polypeptide binding]; other site 1279365012403 motif 1; other site 1279365012404 active site 1279365012405 motif 2; other site 1279365012406 motif 3; other site 1279365012407 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1279365012408 anticodon binding site; other site 1279365012409 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1279365012410 putative active site [active] 1279365012411 dimerization interface [polypeptide binding]; other site 1279365012412 putative tRNAtyr binding site [nucleotide binding]; other site 1279365012413 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1279365012414 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365012415 Zn2+ binding site [ion binding]; other site 1279365012416 Mg2+ binding site [ion binding]; other site 1279365012417 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1279365012418 synthetase active site [active] 1279365012419 NTP binding site [chemical binding]; other site 1279365012420 metal binding site [ion binding]; metal-binding site 1279365012421 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1279365012422 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1279365012423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365012424 active site 1279365012425 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1279365012426 DHH family; Region: DHH; pfam01368 1279365012427 DHHA1 domain; Region: DHHA1; pfam02272 1279365012428 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1279365012429 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1279365012430 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1279365012431 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1279365012432 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1279365012433 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1279365012434 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1279365012435 Protein export membrane protein; Region: SecD_SecF; pfam02355 1279365012436 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1279365012437 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1279365012438 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1279365012439 Predicted membrane protein [Function unknown]; Region: COG2323 1279365012440 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1279365012441 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1279365012442 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1279365012443 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1279365012444 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1279365012445 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1279365012446 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1279365012447 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1279365012448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012449 Walker A motif; other site 1279365012450 ATP binding site [chemical binding]; other site 1279365012451 Walker B motif; other site 1279365012452 arginine finger; other site 1279365012453 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1279365012454 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1279365012455 RuvA N terminal domain; Region: RuvA_N; pfam01330 1279365012456 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1279365012457 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365012458 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1279365012459 putative ligand binding residues [chemical binding]; other site 1279365012460 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1279365012461 BofC C-terminal domain; Region: BofC_C; pfam08955 1279365012462 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1279365012463 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365012464 quinolinate synthetase; Provisional; Region: PRK09375 1279365012465 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1279365012466 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1279365012467 dimerization interface [polypeptide binding]; other site 1279365012468 active site 1279365012469 L-aspartate oxidase; Provisional; Region: PRK08071 1279365012470 L-aspartate oxidase; Provisional; Region: PRK06175 1279365012471 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1279365012472 cysteine desulfurase; Provisional; Region: PRK02948 1279365012473 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1279365012474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365012475 catalytic residue [active] 1279365012476 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1279365012477 HTH domain; Region: HTH_11; pfam08279 1279365012478 3H domain; Region: 3H; pfam02829 1279365012479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1279365012480 MOSC domain; Region: MOSC; pfam03473 1279365012481 3-alpha domain; Region: 3-alpha; pfam03475 1279365012482 prephenate dehydratase; Provisional; Region: PRK11898 1279365012483 Prephenate dehydratase; Region: PDT; pfam00800 1279365012484 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1279365012485 putative L-Phe binding site [chemical binding]; other site 1279365012486 FtsX-like permease family; Region: FtsX; pfam02687 1279365012487 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365012488 FtsX-like permease family; Region: FtsX; pfam02687 1279365012489 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365012490 FtsX-like permease family; Region: FtsX; pfam02687 1279365012491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365012492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365012493 Walker A/P-loop; other site 1279365012494 ATP binding site [chemical binding]; other site 1279365012495 Q-loop/lid; other site 1279365012496 ABC transporter signature motif; other site 1279365012497 Walker B; other site 1279365012498 D-loop; other site 1279365012499 H-loop/switch region; other site 1279365012500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365012501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1279365012502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365012503 ATP binding site [chemical binding]; other site 1279365012504 Mg2+ binding site [ion binding]; other site 1279365012505 G-X-G motif; other site 1279365012506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365012507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365012508 active site 1279365012509 phosphorylation site [posttranslational modification] 1279365012510 intermolecular recognition site; other site 1279365012511 dimerization interface [polypeptide binding]; other site 1279365012512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365012513 DNA binding site [nucleotide binding] 1279365012514 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1279365012515 GTP1/OBG; Region: GTP1_OBG; pfam01018 1279365012516 Obg GTPase; Region: Obg; cd01898 1279365012517 G1 box; other site 1279365012518 GTP/Mg2+ binding site [chemical binding]; other site 1279365012519 Switch I region; other site 1279365012520 G2 box; other site 1279365012521 G3 box; other site 1279365012522 Switch II region; other site 1279365012523 G4 box; other site 1279365012524 G5 box; other site 1279365012525 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1279365012526 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1279365012527 hypothetical protein; Provisional; Region: PRK14553 1279365012528 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1279365012529 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1279365012530 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1279365012531 homodimer interface [polypeptide binding]; other site 1279365012532 oligonucleotide binding site [chemical binding]; other site 1279365012533 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1279365012534 Peptidase family M50; Region: Peptidase_M50; pfam02163 1279365012535 active site 1279365012536 putative substrate binding region [chemical binding]; other site 1279365012537 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365012538 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365012539 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1279365012540 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1279365012541 Switch I; other site 1279365012542 Switch II; other site 1279365012543 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1279365012544 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1279365012545 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1279365012546 rod shape-determining protein MreC; Provisional; Region: PRK13922 1279365012547 rod shape-determining protein MreC; Region: MreC; pfam04085 1279365012548 rod shape-determining protein MreB; Provisional; Region: PRK13927 1279365012549 MreB and similar proteins; Region: MreB_like; cd10225 1279365012550 nucleotide binding site [chemical binding]; other site 1279365012551 Mg binding site [ion binding]; other site 1279365012552 putative protofilament interaction site [polypeptide binding]; other site 1279365012553 RodZ interaction site [polypeptide binding]; other site 1279365012554 hypothetical protein; Reviewed; Region: PRK00024 1279365012555 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1279365012556 MPN+ (JAMM) motif; other site 1279365012557 Zinc-binding site [ion binding]; other site 1279365012558 Maf-like protein; Region: Maf; pfam02545 1279365012559 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1279365012560 active site 1279365012561 dimer interface [polypeptide binding]; other site 1279365012562 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1279365012563 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1279365012564 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1279365012565 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1279365012566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1279365012567 active site 1279365012568 HIGH motif; other site 1279365012569 nucleotide binding site [chemical binding]; other site 1279365012570 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1279365012571 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1279365012572 active site 1279365012573 KMSKS motif; other site 1279365012574 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1279365012575 tRNA binding surface [nucleotide binding]; other site 1279365012576 anticodon binding site; other site 1279365012577 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1279365012578 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1279365012579 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1279365012580 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1279365012581 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1279365012582 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1279365012583 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1279365012584 inhibitor-cofactor binding pocket; inhibition site 1279365012585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365012586 catalytic residue [active] 1279365012587 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1279365012588 dimer interface [polypeptide binding]; other site 1279365012589 active site 1279365012590 Schiff base residues; other site 1279365012591 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1279365012592 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1279365012593 active site 1279365012594 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1279365012595 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1279365012596 domain interfaces; other site 1279365012597 active site 1279365012598 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1279365012599 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1279365012600 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1279365012601 tRNA; other site 1279365012602 putative tRNA binding site [nucleotide binding]; other site 1279365012603 putative NADP binding site [chemical binding]; other site 1279365012604 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1279365012605 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1279365012606 MarR family; Region: MarR; pfam01047 1279365012607 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1279365012608 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1279365012609 G1 box; other site 1279365012610 GTP/Mg2+ binding site [chemical binding]; other site 1279365012611 Switch I region; other site 1279365012612 G2 box; other site 1279365012613 G3 box; other site 1279365012614 Switch II region; other site 1279365012615 G4 box; other site 1279365012616 G5 box; other site 1279365012617 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1279365012618 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1279365012619 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1279365012620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012621 Walker A motif; other site 1279365012622 ATP binding site [chemical binding]; other site 1279365012623 Walker B motif; other site 1279365012624 arginine finger; other site 1279365012625 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1279365012626 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1279365012627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012628 Walker A motif; other site 1279365012629 ATP binding site [chemical binding]; other site 1279365012630 Walker B motif; other site 1279365012631 arginine finger; other site 1279365012632 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1279365012633 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1279365012634 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1279365012635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012636 Walker A motif; other site 1279365012637 ATP binding site [chemical binding]; other site 1279365012638 Walker B motif; other site 1279365012639 arginine finger; other site 1279365012640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1279365012641 trigger factor; Provisional; Region: tig; PRK01490 1279365012642 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1279365012643 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1279365012644 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1279365012645 pentamer interface [polypeptide binding]; other site 1279365012646 dodecaamer interface [polypeptide binding]; other site 1279365012647 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1279365012648 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1279365012649 active site 1279365012650 metal binding site [ion binding]; metal-binding site 1279365012651 homotetramer interface [polypeptide binding]; other site 1279365012652 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1279365012653 active site 1279365012654 dimerization interface [polypeptide binding]; other site 1279365012655 ribonuclease PH; Reviewed; Region: rph; PRK00173 1279365012656 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1279365012657 hexamer interface [polypeptide binding]; other site 1279365012658 active site 1279365012659 Sporulation and spore germination; Region: Germane; pfam10646 1279365012660 Spore germination protein [General function prediction only]; Region: COG5401 1279365012661 Sporulation and spore germination; Region: Germane; pfam10646 1279365012662 glutamate racemase; Provisional; Region: PRK00865 1279365012663 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1279365012664 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1279365012665 potential catalytic triad [active] 1279365012666 conserved cys residue [active] 1279365012667 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365012668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365012669 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365012670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365012671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365012672 DNA binding residues [nucleotide binding] 1279365012673 dimerization interface [polypeptide binding]; other site 1279365012674 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1279365012675 putative deaminase; Validated; Region: PRK06846 1279365012676 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1279365012677 active site 1279365012678 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1279365012679 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365012680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365012681 non-specific DNA binding site [nucleotide binding]; other site 1279365012682 salt bridge; other site 1279365012683 sequence-specific DNA binding site [nucleotide binding]; other site 1279365012684 Cupin domain; Region: Cupin_2; pfam07883 1279365012685 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1279365012686 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1279365012687 amphipathic channel; other site 1279365012688 Asn-Pro-Ala signature motifs; other site 1279365012689 Predicted transcriptional regulator [Transcription]; Region: COG1959 1279365012690 Transcriptional regulator; Region: Rrf2; pfam02082 1279365012691 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1279365012692 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1279365012693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365012694 Walker A/P-loop; other site 1279365012695 ATP binding site [chemical binding]; other site 1279365012696 Q-loop/lid; other site 1279365012697 ABC transporter signature motif; other site 1279365012698 Walker B; other site 1279365012699 D-loop; other site 1279365012700 H-loop/switch region; other site 1279365012701 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1279365012702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365012703 active site 1279365012704 motif I; other site 1279365012705 motif II; other site 1279365012706 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1279365012707 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1279365012708 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1279365012709 ligand binding site [chemical binding]; other site 1279365012710 flagellar motor protein MotA; Validated; Region: PRK08124 1279365012711 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1279365012712 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1279365012713 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1279365012714 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1279365012715 active site 1279365012716 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1279365012717 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1279365012718 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1279365012719 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1279365012720 L-aspartate oxidase; Provisional; Region: PRK06175 1279365012721 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1279365012722 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1279365012723 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1279365012724 putative Iron-sulfur protein interface [polypeptide binding]; other site 1279365012725 proximal heme binding site [chemical binding]; other site 1279365012726 distal heme binding site [chemical binding]; other site 1279365012727 putative dimer interface [polypeptide binding]; other site 1279365012728 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1279365012729 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1279365012730 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1279365012731 GIY-YIG motif/motif A; other site 1279365012732 active site 1279365012733 catalytic site [active] 1279365012734 putative DNA binding site [nucleotide binding]; other site 1279365012735 metal binding site [ion binding]; metal-binding site 1279365012736 UvrB/uvrC motif; Region: UVR; pfam02151 1279365012737 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1279365012738 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365012739 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1279365012740 catalytic residues [active] 1279365012741 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1279365012742 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1279365012743 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1279365012744 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1279365012745 Ligand binding site [chemical binding]; other site 1279365012746 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1279365012747 enoyl-CoA hydratase; Provisional; Region: PRK07658 1279365012748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1279365012749 substrate binding site [chemical binding]; other site 1279365012750 oxyanion hole (OAH) forming residues; other site 1279365012751 trimer interface [polypeptide binding]; other site 1279365012752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1279365012753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365012754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365012755 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1279365012756 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1279365012757 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1279365012758 acyl-activating enzyme (AAE) consensus motif; other site 1279365012759 putative AMP binding site [chemical binding]; other site 1279365012760 putative active site [active] 1279365012761 putative CoA binding site [chemical binding]; other site 1279365012762 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1279365012763 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1279365012764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365012765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365012766 DNA binding residues [nucleotide binding] 1279365012767 DinB family; Region: DinB; pfam05163 1279365012768 DinB superfamily; Region: DinB_2; pfam12867 1279365012769 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1279365012770 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1279365012771 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1279365012772 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1279365012773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365012774 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1279365012775 Walker A/P-loop; other site 1279365012776 ATP binding site [chemical binding]; other site 1279365012777 Q-loop/lid; other site 1279365012778 ABC transporter signature motif; other site 1279365012779 Walker B; other site 1279365012780 D-loop; other site 1279365012781 H-loop/switch region; other site 1279365012782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365012783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365012784 dimer interface [polypeptide binding]; other site 1279365012785 phosphorylation site [posttranslational modification] 1279365012786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365012787 ATP binding site [chemical binding]; other site 1279365012788 Mg2+ binding site [ion binding]; other site 1279365012789 G-X-G motif; other site 1279365012790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365012791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365012792 active site 1279365012793 phosphorylation site [posttranslational modification] 1279365012794 intermolecular recognition site; other site 1279365012795 dimerization interface [polypeptide binding]; other site 1279365012796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365012797 DNA binding site [nucleotide binding] 1279365012798 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1279365012799 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1279365012800 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1279365012801 putative RNA binding site [nucleotide binding]; other site 1279365012802 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 1279365012803 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1279365012804 active site 1279365012805 catalytic site [active] 1279365012806 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1279365012807 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1279365012808 Walker A/P-loop; other site 1279365012809 ATP binding site [chemical binding]; other site 1279365012810 Q-loop/lid; other site 1279365012811 ABC transporter signature motif; other site 1279365012812 Walker B; other site 1279365012813 D-loop; other site 1279365012814 H-loop/switch region; other site 1279365012815 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365012816 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365012817 ABC-ATPase subunit interface; other site 1279365012818 dimer interface [polypeptide binding]; other site 1279365012819 putative PBP binding regions; other site 1279365012820 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1279365012821 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1279365012822 intersubunit interface [polypeptide binding]; other site 1279365012823 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365012824 heme-binding site [chemical binding]; other site 1279365012825 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365012826 heme-binding site [chemical binding]; other site 1279365012827 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365012828 heme-binding site [chemical binding]; other site 1279365012829 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365012830 heme-binding site [chemical binding]; other site 1279365012831 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365012832 heme-binding site [chemical binding]; other site 1279365012833 heme uptake protein IsdC; Region: IsdC; TIGR03656 1279365012834 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1279365012835 heme-binding site [chemical binding]; other site 1279365012836 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1279365012837 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1279365012838 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1279365012839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365012840 RNA binding surface [nucleotide binding]; other site 1279365012841 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1279365012842 probable active site [active] 1279365012843 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1279365012844 MutS domain III; Region: MutS_III; pfam05192 1279365012845 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1279365012846 Walker A/P-loop; other site 1279365012847 ATP binding site [chemical binding]; other site 1279365012848 Q-loop/lid; other site 1279365012849 ABC transporter signature motif; other site 1279365012850 Walker B; other site 1279365012851 D-loop; other site 1279365012852 H-loop/switch region; other site 1279365012853 Smr domain; Region: Smr; pfam01713 1279365012854 hypothetical protein; Provisional; Region: PRK08609 1279365012855 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1279365012856 active site 1279365012857 primer binding site [nucleotide binding]; other site 1279365012858 NTP binding site [chemical binding]; other site 1279365012859 metal binding triad [ion binding]; metal-binding site 1279365012860 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1279365012861 active site 1279365012862 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1279365012863 Colicin V production protein; Region: Colicin_V; pfam02674 1279365012864 cell division protein ZapA; Provisional; Region: PRK14126 1279365012865 ribonuclease HIII; Provisional; Region: PRK00996 1279365012866 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1279365012867 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1279365012868 RNA/DNA hybrid binding site [nucleotide binding]; other site 1279365012869 active site 1279365012870 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1279365012871 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1279365012872 putative dimer interface [polypeptide binding]; other site 1279365012873 putative anticodon binding site; other site 1279365012874 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1279365012875 homodimer interface [polypeptide binding]; other site 1279365012876 motif 1; other site 1279365012877 motif 2; other site 1279365012878 active site 1279365012879 motif 3; other site 1279365012880 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1279365012881 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1279365012882 putative tRNA-binding site [nucleotide binding]; other site 1279365012883 B3/4 domain; Region: B3_4; pfam03483 1279365012884 tRNA synthetase B5 domain; Region: B5; smart00874 1279365012885 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1279365012886 dimer interface [polypeptide binding]; other site 1279365012887 motif 1; other site 1279365012888 motif 3; other site 1279365012889 motif 2; other site 1279365012890 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1279365012891 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1279365012892 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1279365012893 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1279365012894 dimer interface [polypeptide binding]; other site 1279365012895 motif 1; other site 1279365012896 active site 1279365012897 motif 2; other site 1279365012898 motif 3; other site 1279365012899 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1279365012900 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1279365012901 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1279365012902 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1279365012903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365012904 Zn2+ binding site [ion binding]; other site 1279365012905 Mg2+ binding site [ion binding]; other site 1279365012906 CAAX protease self-immunity; Region: Abi; pfam02517 1279365012907 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1279365012908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365012909 putative substrate translocation pore; other site 1279365012910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365012911 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1279365012912 HlyD family secretion protein; Region: HlyD_3; pfam13437 1279365012913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365012914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365012915 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1279365012916 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1279365012917 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1279365012918 oligomer interface [polypeptide binding]; other site 1279365012919 active site 1279365012920 metal binding site [ion binding]; metal-binding site 1279365012921 dUTPase; Region: dUTPase_2; pfam08761 1279365012922 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1279365012923 active site 1279365012924 homodimer interface [polypeptide binding]; other site 1279365012925 metal binding site [ion binding]; metal-binding site 1279365012926 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1279365012927 23S rRNA binding site [nucleotide binding]; other site 1279365012928 L21 binding site [polypeptide binding]; other site 1279365012929 L13 binding site [polypeptide binding]; other site 1279365012930 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1279365012931 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1279365012932 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1279365012933 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1279365012934 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1279365012935 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1279365012936 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1279365012937 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1279365012938 active site 1279365012939 dimer interface [polypeptide binding]; other site 1279365012940 motif 1; other site 1279365012941 motif 2; other site 1279365012942 motif 3; other site 1279365012943 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1279365012944 anticodon binding site; other site 1279365012945 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1279365012946 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1279365012947 primosomal protein DnaI; Reviewed; Region: PRK08939 1279365012948 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1279365012949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365012950 Walker A motif; other site 1279365012951 ATP binding site [chemical binding]; other site 1279365012952 Walker B motif; other site 1279365012953 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1279365012954 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1279365012955 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1279365012956 ATP cone domain; Region: ATP-cone; pfam03477 1279365012957 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1279365012958 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1279365012959 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1279365012960 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1279365012961 dephospho-CoA kinase; Region: TIGR00152 1279365012962 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1279365012963 CoA-binding site [chemical binding]; other site 1279365012964 ATP-binding [chemical binding]; other site 1279365012965 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1279365012966 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1279365012967 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1279365012968 DNA binding site [nucleotide binding] 1279365012969 catalytic residue [active] 1279365012970 H2TH interface [polypeptide binding]; other site 1279365012971 putative catalytic residues [active] 1279365012972 turnover-facilitating residue; other site 1279365012973 intercalation triad [nucleotide binding]; other site 1279365012974 8OG recognition residue [nucleotide binding]; other site 1279365012975 putative reading head residues; other site 1279365012976 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1279365012977 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1279365012978 DNA polymerase I; Provisional; Region: PRK05755 1279365012979 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1279365012980 active site 1279365012981 metal binding site 1 [ion binding]; metal-binding site 1279365012982 putative 5' ssDNA interaction site; other site 1279365012983 metal binding site 3; metal-binding site 1279365012984 metal binding site 2 [ion binding]; metal-binding site 1279365012985 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1279365012986 putative DNA binding site [nucleotide binding]; other site 1279365012987 putative metal binding site [ion binding]; other site 1279365012988 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1279365012989 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1279365012990 active site 1279365012991 DNA binding site [nucleotide binding] 1279365012992 catalytic site [active] 1279365012993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365012994 dimerization interface [polypeptide binding]; other site 1279365012995 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1279365012996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365012997 putative active site [active] 1279365012998 heme pocket [chemical binding]; other site 1279365012999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365013000 dimer interface [polypeptide binding]; other site 1279365013001 phosphorylation site [posttranslational modification] 1279365013002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013003 ATP binding site [chemical binding]; other site 1279365013004 Mg2+ binding site [ion binding]; other site 1279365013005 G-X-G motif; other site 1279365013006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365013007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013008 active site 1279365013009 phosphorylation site [posttranslational modification] 1279365013010 intermolecular recognition site; other site 1279365013011 dimerization interface [polypeptide binding]; other site 1279365013012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365013013 DNA binding site [nucleotide binding] 1279365013014 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1279365013015 active site 2 [active] 1279365013016 active site 1 [active] 1279365013017 malate dehydrogenase; Reviewed; Region: PRK06223 1279365013018 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1279365013019 NAD(P) binding site [chemical binding]; other site 1279365013020 dimer interface [polypeptide binding]; other site 1279365013021 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365013022 substrate binding site [chemical binding]; other site 1279365013023 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1279365013024 isocitrate dehydrogenase; Validated; Region: PRK07362 1279365013025 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1279365013026 dimer interface [polypeptide binding]; other site 1279365013027 Citrate synthase; Region: Citrate_synt; pfam00285 1279365013028 active site 1279365013029 citrylCoA binding site [chemical binding]; other site 1279365013030 oxalacetate/citrate binding site [chemical binding]; other site 1279365013031 coenzyme A binding site [chemical binding]; other site 1279365013032 catalytic triad [active] 1279365013033 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1279365013034 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1279365013035 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1279365013036 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1279365013037 pyruvate kinase; Provisional; Region: PRK06354 1279365013038 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1279365013039 domain interfaces; other site 1279365013040 active site 1279365013041 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1279365013042 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1279365013043 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1279365013044 active site 1279365013045 ADP/pyrophosphate binding site [chemical binding]; other site 1279365013046 dimerization interface [polypeptide binding]; other site 1279365013047 allosteric effector site; other site 1279365013048 fructose-1,6-bisphosphate binding site; other site 1279365013049 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1279365013050 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1279365013051 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1279365013052 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1279365013053 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1279365013054 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1279365013055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365013056 DNA-binding site [nucleotide binding]; DNA binding site 1279365013057 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1279365013058 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1279365013059 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1279365013060 putative NAD(P) binding site [chemical binding]; other site 1279365013061 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1279365013062 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1279365013063 active site 1279365013064 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1279365013065 generic binding surface II; other site 1279365013066 generic binding surface I; other site 1279365013067 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1279365013068 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1279365013069 DHH family; Region: DHH; pfam01368 1279365013070 DHHA1 domain; Region: DHHA1; pfam02272 1279365013071 YtpI-like protein; Region: YtpI; pfam14007 1279365013072 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 1279365013073 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1279365013074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365013075 DNA-binding site [nucleotide binding]; DNA binding site 1279365013076 DRTGG domain; Region: DRTGG; pfam07085 1279365013077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1279365013078 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1279365013079 active site 2 [active] 1279365013080 active site 1 [active] 1279365013081 metal-dependent hydrolase; Provisional; Region: PRK00685 1279365013082 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1279365013083 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1279365013084 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1279365013085 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1279365013086 active site 1279365013087 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1279365013088 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1279365013089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365013090 Coenzyme A binding pocket [chemical binding]; other site 1279365013091 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365013092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365013093 Coenzyme A binding pocket [chemical binding]; other site 1279365013094 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1279365013095 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1279365013096 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1279365013097 hexamer interface [polypeptide binding]; other site 1279365013098 ligand binding site [chemical binding]; other site 1279365013099 putative active site [active] 1279365013100 NAD(P) binding site [chemical binding]; other site 1279365013101 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1279365013102 classical (c) SDRs; Region: SDR_c; cd05233 1279365013103 NAD(P) binding site [chemical binding]; other site 1279365013104 active site 1279365013105 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1279365013106 Ligand Binding Site [chemical binding]; other site 1279365013107 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1279365013108 argininosuccinate lyase; Provisional; Region: PRK00855 1279365013109 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1279365013110 active sites [active] 1279365013111 tetramer interface [polypeptide binding]; other site 1279365013112 argininosuccinate synthase; Provisional; Region: PRK13820 1279365013113 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1279365013114 ANP binding site [chemical binding]; other site 1279365013115 Substrate Binding Site II [chemical binding]; other site 1279365013116 Substrate Binding Site I [chemical binding]; other site 1279365013117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365013118 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365013119 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365013120 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365013121 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365013122 EcsC protein family; Region: EcsC; pfam12787 1279365013123 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1279365013124 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1279365013125 nudix motif; other site 1279365013126 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1279365013127 propionate/acetate kinase; Provisional; Region: PRK12379 1279365013128 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1279365013129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365013130 S-adenosylmethionine binding site [chemical binding]; other site 1279365013131 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1279365013132 dimer interface [polypeptide binding]; other site 1279365013133 catalytic triad [active] 1279365013134 peroxidatic and resolving cysteines [active] 1279365013135 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1279365013136 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1279365013137 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1279365013138 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1279365013139 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1279365013140 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1279365013141 active site 1279365013142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365013143 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1279365013144 dimer interface [polypeptide binding]; other site 1279365013145 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1279365013146 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1279365013147 active site 1279365013148 acyl-activating enzyme (AAE) consensus motif; other site 1279365013149 putative CoA binding site [chemical binding]; other site 1279365013150 AMP binding site [chemical binding]; other site 1279365013151 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1279365013152 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1279365013153 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1279365013154 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1279365013155 Ligand Binding Site [chemical binding]; other site 1279365013156 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1279365013157 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1279365013158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365013159 catalytic residue [active] 1279365013160 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1279365013161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365013162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365013163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1279365013164 dimerization interface [polypeptide binding]; other site 1279365013165 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365013166 EamA-like transporter family; Region: EamA; pfam00892 1279365013167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365013168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365013169 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1279365013170 GAF domain; Region: GAF_2; pfam13185 1279365013171 methionine gamma-lyase; Provisional; Region: PRK06767 1279365013172 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1279365013173 homodimer interface [polypeptide binding]; other site 1279365013174 substrate-cofactor binding pocket; other site 1279365013175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365013176 catalytic residue [active] 1279365013177 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1279365013178 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1279365013179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365013180 RNA binding surface [nucleotide binding]; other site 1279365013181 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1279365013182 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1279365013183 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1279365013184 active site 1279365013185 HIGH motif; other site 1279365013186 dimer interface [polypeptide binding]; other site 1279365013187 KMSKS motif; other site 1279365013188 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365013189 RNA binding surface [nucleotide binding]; other site 1279365013190 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1279365013191 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1279365013192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365013193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365013194 DNA binding residues [nucleotide binding] 1279365013195 maltose O-acetyltransferase; Provisional; Region: PRK10092 1279365013196 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1279365013197 active site 1279365013198 substrate binding site [chemical binding]; other site 1279365013199 trimer interface [polypeptide binding]; other site 1279365013200 CoA binding site [chemical binding]; other site 1279365013201 acetyl-CoA synthetase; Provisional; Region: PRK04319 1279365013202 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1279365013203 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1279365013204 active site 1279365013205 acyl-activating enzyme (AAE) consensus motif; other site 1279365013206 putative CoA binding site [chemical binding]; other site 1279365013207 AMP binding site [chemical binding]; other site 1279365013208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365013209 Coenzyme A binding pocket [chemical binding]; other site 1279365013210 FOG: CBS domain [General function prediction only]; Region: COG0517 1279365013211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1279365013212 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1279365013213 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1279365013214 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1279365013215 active site 1279365013216 Zn binding site [ion binding]; other site 1279365013217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365013218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365013219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013220 active site 1279365013221 phosphorylation site [posttranslational modification] 1279365013222 intermolecular recognition site; other site 1279365013223 dimerization interface [polypeptide binding]; other site 1279365013224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365013225 DNA binding site [nucleotide binding] 1279365013226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365013227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365013228 dimerization interface [polypeptide binding]; other site 1279365013229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365013230 dimer interface [polypeptide binding]; other site 1279365013231 phosphorylation site [posttranslational modification] 1279365013232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013233 ATP binding site [chemical binding]; other site 1279365013234 Mg2+ binding site [ion binding]; other site 1279365013235 G-X-G motif; other site 1279365013236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365013237 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365013238 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365013239 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1279365013240 Ankyrin repeat; Region: Ank; pfam00023 1279365013241 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1279365013242 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1279365013243 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1279365013244 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1279365013245 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1279365013246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365013247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365013248 dimer interface [polypeptide binding]; other site 1279365013249 phosphorylation site [posttranslational modification] 1279365013250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013251 ATP binding site [chemical binding]; other site 1279365013252 Mg2+ binding site [ion binding]; other site 1279365013253 G-X-G motif; other site 1279365013254 Response regulator receiver domain; Region: Response_reg; pfam00072 1279365013255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013256 active site 1279365013257 phosphorylation site [posttranslational modification] 1279365013258 intermolecular recognition site; other site 1279365013259 dimerization interface [polypeptide binding]; other site 1279365013260 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1279365013261 Histidine kinase; Region: His_kinase; pfam06580 1279365013262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013263 ATP binding site [chemical binding]; other site 1279365013264 Mg2+ binding site [ion binding]; other site 1279365013265 G-X-G motif; other site 1279365013266 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1279365013267 active site 1279365013268 catalytic site [active] 1279365013269 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365013270 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013271 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365013272 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1279365013273 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1279365013274 metal ion-dependent adhesion site (MIDAS); other site 1279365013275 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013276 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013277 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013278 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365013279 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1279365013280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013281 active site 1279365013282 phosphorylation site [posttranslational modification] 1279365013283 intermolecular recognition site; other site 1279365013284 dimerization interface [polypeptide binding]; other site 1279365013285 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1279365013286 DNA binding site [nucleotide binding] 1279365013287 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1279365013288 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1279365013289 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1279365013290 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1279365013291 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 1279365013292 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 1279365013293 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 1279365013294 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1279365013295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365013296 DNA binding site [nucleotide binding] 1279365013297 domain linker motif; other site 1279365013298 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1279365013299 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1279365013300 Chorismate mutase type II; Region: CM_2; cl00693 1279365013301 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1279365013302 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1279365013303 putative dimer interface [polypeptide binding]; other site 1279365013304 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1279365013305 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1279365013306 putative dimer interface [polypeptide binding]; other site 1279365013307 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1279365013308 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1279365013309 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1279365013310 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1279365013311 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1279365013312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365013313 Coenzyme A binding pocket [chemical binding]; other site 1279365013314 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365013315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365013316 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1279365013317 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1279365013318 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1279365013319 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1279365013320 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 1279365013321 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 1279365013322 active site 1279365013323 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1279365013324 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365013325 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1279365013326 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1279365013327 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1279365013328 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1279365013329 active site 1279365013330 metal binding site [ion binding]; metal-binding site 1279365013331 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1279365013332 putative tRNA-binding site [nucleotide binding]; other site 1279365013333 hypothetical protein; Provisional; Region: PRK13668 1279365013334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365013335 catalytic residues [active] 1279365013336 NTPase; Reviewed; Region: PRK03114 1279365013337 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1279365013338 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1279365013339 oligomer interface [polypeptide binding]; other site 1279365013340 active site 1279365013341 metal binding site [ion binding]; metal-binding site 1279365013342 Predicted small secreted protein [Function unknown]; Region: COG5584 1279365013343 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365013344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365013345 S-adenosylmethionine binding site [chemical binding]; other site 1279365013346 YtzH-like protein; Region: YtzH; pfam14165 1279365013347 Phosphotransferase enzyme family; Region: APH; pfam01636 1279365013348 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1279365013349 active site 1279365013350 substrate binding site [chemical binding]; other site 1279365013351 ATP binding site [chemical binding]; other site 1279365013352 pullulanase, type I; Region: pulA_typeI; TIGR02104 1279365013353 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1279365013354 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1279365013355 Ca binding site [ion binding]; other site 1279365013356 active site 1279365013357 catalytic site [active] 1279365013358 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1279365013359 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1279365013360 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1279365013361 dipeptidase PepV; Reviewed; Region: PRK07318 1279365013362 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1279365013363 active site 1279365013364 metal binding site [ion binding]; metal-binding site 1279365013365 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1279365013366 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1279365013367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365013368 RNA binding surface [nucleotide binding]; other site 1279365013369 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1279365013370 active site 1279365013371 uracil binding [chemical binding]; other site 1279365013372 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1279365013373 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1279365013374 HI0933-like protein; Region: HI0933_like; pfam03486 1279365013375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365013376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365013377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365013378 putative substrate translocation pore; other site 1279365013379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365013380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365013381 dimerization interface [polypeptide binding]; other site 1279365013382 putative DNA binding site [nucleotide binding]; other site 1279365013383 putative Zn2+ binding site [ion binding]; other site 1279365013384 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1279365013385 putative hydrophobic ligand binding site [chemical binding]; other site 1279365013386 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 1279365013387 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1279365013388 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1279365013389 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1279365013390 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1279365013391 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1279365013392 NAD binding site [chemical binding]; other site 1279365013393 homodimer interface [polypeptide binding]; other site 1279365013394 active site 1279365013395 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1279365013396 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1279365013397 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1279365013398 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1279365013399 MoaE interaction surface [polypeptide binding]; other site 1279365013400 MoeB interaction surface [polypeptide binding]; other site 1279365013401 thiocarboxylated glycine; other site 1279365013402 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1279365013403 MoaE homodimer interface [polypeptide binding]; other site 1279365013404 MoaD interaction [polypeptide binding]; other site 1279365013405 active site residues [active] 1279365013406 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1279365013407 Walker A motif; other site 1279365013408 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1279365013409 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1279365013410 dimer interface [polypeptide binding]; other site 1279365013411 putative functional site; other site 1279365013412 putative MPT binding site; other site 1279365013413 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1279365013414 trimer interface [polypeptide binding]; other site 1279365013415 dimer interface [polypeptide binding]; other site 1279365013416 putative active site [active] 1279365013417 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1279365013418 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1279365013419 ATP binding site [chemical binding]; other site 1279365013420 substrate interface [chemical binding]; other site 1279365013421 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1279365013422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365013423 FeS/SAM binding site; other site 1279365013424 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1279365013425 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365013426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1279365013427 active site residue [active] 1279365013428 homoserine O-acetyltransferase; Provisional; Region: PRK06765 1279365013429 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1279365013430 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1279365013431 Spore germination protein; Region: Spore_permease; pfam03845 1279365013432 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1279365013433 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1279365013434 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1279365013435 putative nucleotide binding site [chemical binding]; other site 1279365013436 putative metal binding site [ion binding]; other site 1279365013437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1279365013438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365013439 Coenzyme A binding pocket [chemical binding]; other site 1279365013440 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1279365013441 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1279365013442 HIGH motif; other site 1279365013443 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1279365013444 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1279365013445 active site 1279365013446 KMSKS motif; other site 1279365013447 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1279365013448 tRNA binding surface [nucleotide binding]; other site 1279365013449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365013450 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365013451 putative substrate translocation pore; other site 1279365013452 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1279365013453 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365013454 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1279365013455 TrkA-C domain; Region: TrkA_C; pfam02080 1279365013456 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1279365013457 Int/Topo IB signature motif; other site 1279365013458 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365013459 FtsX-like permease family; Region: FtsX; pfam02687 1279365013460 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365013461 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365013462 Walker A/P-loop; other site 1279365013463 ATP binding site [chemical binding]; other site 1279365013464 Q-loop/lid; other site 1279365013465 ABC transporter signature motif; other site 1279365013466 Walker B; other site 1279365013467 D-loop; other site 1279365013468 H-loop/switch region; other site 1279365013469 Predicted membrane protein [Function unknown]; Region: COG2311 1279365013470 Protein of unknown function (DUF418); Region: DUF418; cl12135 1279365013471 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1279365013472 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1279365013473 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1279365013474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365013475 FeS/SAM binding site; other site 1279365013476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365013477 S-adenosylmethionine binding site [chemical binding]; other site 1279365013478 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1279365013479 aspartate racemase; Region: asp_race; TIGR00035 1279365013480 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1279365013481 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1279365013482 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1279365013483 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1279365013484 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1279365013485 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365013486 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365013487 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1279365013488 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1279365013489 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1279365013490 trimer interface [polypeptide binding]; other site 1279365013491 putative metal binding site [ion binding]; other site 1279365013492 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1279365013493 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1279365013494 active site 1279365013495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1279365013496 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1279365013497 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1279365013498 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1279365013499 GTP binding site; other site 1279365013500 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1279365013501 MPT binding site; other site 1279365013502 trimer interface [polypeptide binding]; other site 1279365013503 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365013504 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365013505 Coenzyme A binding pocket [chemical binding]; other site 1279365013506 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1279365013507 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1279365013508 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1279365013509 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1279365013510 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1279365013511 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1279365013512 active site 1279365013513 substrate-binding site [chemical binding]; other site 1279365013514 metal-binding site [ion binding] 1279365013515 ATP binding site [chemical binding]; other site 1279365013516 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1279365013517 EamA-like transporter family; Region: EamA; pfam00892 1279365013518 EamA-like transporter family; Region: EamA; pfam00892 1279365013519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1279365013520 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1279365013521 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1279365013522 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1279365013523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365013524 motif II; other site 1279365013525 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1279365013526 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1279365013527 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1279365013528 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1279365013529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365013530 motif II; other site 1279365013531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365013532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013533 ATP binding site [chemical binding]; other site 1279365013534 Mg2+ binding site [ion binding]; other site 1279365013535 G-X-G motif; other site 1279365013536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365013537 dimer interface [polypeptide binding]; other site 1279365013538 phosphorylation site [posttranslational modification] 1279365013539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013540 ATP binding site [chemical binding]; other site 1279365013541 Mg2+ binding site [ion binding]; other site 1279365013542 G-X-G motif; other site 1279365013543 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1279365013544 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1279365013545 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1279365013546 Sulfatase; Region: Sulfatase; pfam00884 1279365013547 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1279365013548 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 1279365013549 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 1279365013550 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1279365013551 NMT1-like family; Region: NMT1_2; pfam13379 1279365013552 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1279365013553 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1279365013554 Walker A/P-loop; other site 1279365013555 ATP binding site [chemical binding]; other site 1279365013556 Q-loop/lid; other site 1279365013557 ABC transporter signature motif; other site 1279365013558 Walker B; other site 1279365013559 D-loop; other site 1279365013560 H-loop/switch region; other site 1279365013561 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1279365013562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365013563 dimer interface [polypeptide binding]; other site 1279365013564 conserved gate region; other site 1279365013565 putative PBP binding loops; other site 1279365013566 ABC-ATPase subunit interface; other site 1279365013567 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1279365013568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365013569 motif II; other site 1279365013570 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1279365013571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1279365013572 nudix motif; other site 1279365013573 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 1279365013574 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1279365013575 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1279365013576 Haemolytic domain; Region: Haemolytic; pfam01809 1279365013577 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1279365013578 active site clefts [active] 1279365013579 zinc binding site [ion binding]; other site 1279365013580 dimer interface [polypeptide binding]; other site 1279365013581 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1279365013582 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1279365013583 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1279365013584 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1279365013585 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1279365013586 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1279365013587 putative active site [active] 1279365013588 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365013589 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365013590 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365013591 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365013592 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1279365013593 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1279365013594 Predicted membrane protein [Function unknown]; Region: COG3766 1279365013595 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1279365013596 hypothetical protein; Provisional; Region: PRK12473 1279365013597 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1279365013598 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1279365013599 G1 box; other site 1279365013600 GTP/Mg2+ binding site [chemical binding]; other site 1279365013601 Switch I region; other site 1279365013602 G2 box; other site 1279365013603 G3 box; other site 1279365013604 Switch II region; other site 1279365013605 G4 box; other site 1279365013606 G5 box; other site 1279365013607 Nucleoside recognition; Region: Gate; pfam07670 1279365013608 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1279365013609 Nucleoside recognition; Region: Gate; pfam07670 1279365013610 FeoA domain; Region: FeoA; pfam04023 1279365013611 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 1279365013612 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1279365013613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365013614 dimerization interface [polypeptide binding]; other site 1279365013615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365013616 dimer interface [polypeptide binding]; other site 1279365013617 phosphorylation site [posttranslational modification] 1279365013618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013619 ATP binding site [chemical binding]; other site 1279365013620 Mg2+ binding site [ion binding]; other site 1279365013621 G-X-G motif; other site 1279365013622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365013623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013624 active site 1279365013625 phosphorylation site [posttranslational modification] 1279365013626 intermolecular recognition site; other site 1279365013627 dimerization interface [polypeptide binding]; other site 1279365013628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365013629 DNA binding site [nucleotide binding] 1279365013630 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1279365013631 active site 1279365013632 catalytic site [active] 1279365013633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365013634 active site 1279365013635 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1279365013636 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1279365013637 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1279365013638 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1279365013639 active site 1279365013640 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1279365013641 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365013642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365013643 S-adenosylmethionine binding site [chemical binding]; other site 1279365013644 FtsX-like permease family; Region: FtsX; pfam02687 1279365013645 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365013646 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365013647 Walker A/P-loop; other site 1279365013648 ATP binding site [chemical binding]; other site 1279365013649 Q-loop/lid; other site 1279365013650 ABC transporter signature motif; other site 1279365013651 Walker B; other site 1279365013652 D-loop; other site 1279365013653 H-loop/switch region; other site 1279365013654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1279365013655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1279365013656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1279365013657 Predicted integral membrane protein [Function unknown]; Region: COG5658 1279365013658 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1279365013659 SdpI/YhfL protein family; Region: SdpI; pfam13630 1279365013660 Predicted integral membrane protein [Function unknown]; Region: COG5658 1279365013661 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1279365013662 SdpI/YhfL protein family; Region: SdpI; pfam13630 1279365013663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365013664 dimerization interface [polypeptide binding]; other site 1279365013665 putative DNA binding site [nucleotide binding]; other site 1279365013666 putative Zn2+ binding site [ion binding]; other site 1279365013667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365013668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013669 active site 1279365013670 phosphorylation site [posttranslational modification] 1279365013671 intermolecular recognition site; other site 1279365013672 dimerization interface [polypeptide binding]; other site 1279365013673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365013674 DNA binding site [nucleotide binding] 1279365013675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365013676 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1279365013677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013678 ATP binding site [chemical binding]; other site 1279365013679 Mg2+ binding site [ion binding]; other site 1279365013680 G-X-G motif; other site 1279365013681 FtsX-like permease family; Region: FtsX; pfam02687 1279365013682 FtsX-like permease family; Region: FtsX; pfam02687 1279365013683 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365013684 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365013685 Walker A/P-loop; other site 1279365013686 ATP binding site [chemical binding]; other site 1279365013687 Q-loop/lid; other site 1279365013688 ABC transporter signature motif; other site 1279365013689 Walker B; other site 1279365013690 D-loop; other site 1279365013691 H-loop/switch region; other site 1279365013692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365013693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365013694 GntP family permease; Region: GntP_permease; pfam02447 1279365013695 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1279365013696 Transposase; Region: HTH_Tnp_1; cl17663 1279365013697 putative transposase OrfB; Reviewed; Region: PHA02517 1279365013698 HTH-like domain; Region: HTH_21; pfam13276 1279365013699 Integrase core domain; Region: rve; pfam00665 1279365013700 Integrase core domain; Region: rve_2; pfam13333 1279365013701 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1279365013702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1279365013703 DNA-binding site [nucleotide binding]; DNA binding site 1279365013704 UTRA domain; Region: UTRA; pfam07702 1279365013705 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1279365013706 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1279365013707 substrate binding site [chemical binding]; other site 1279365013708 ATP binding site [chemical binding]; other site 1279365013709 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1279365013710 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1279365013711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365013712 catalytic residue [active] 1279365013713 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1279365013714 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1279365013715 active site 1279365013716 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1279365013717 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1279365013718 dimerization interface [polypeptide binding]; other site 1279365013719 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1279365013720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365013721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365013722 dimer interface [polypeptide binding]; other site 1279365013723 phosphorylation site [posttranslational modification] 1279365013724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365013725 ATP binding site [chemical binding]; other site 1279365013726 Mg2+ binding site [ion binding]; other site 1279365013727 G-X-G motif; other site 1279365013728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365013729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365013730 active site 1279365013731 phosphorylation site [posttranslational modification] 1279365013732 intermolecular recognition site; other site 1279365013733 dimerization interface [polypeptide binding]; other site 1279365013734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365013735 DNA binding site [nucleotide binding] 1279365013736 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1279365013737 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1279365013738 active site 1279365013739 octamer interface [polypeptide binding]; other site 1279365013740 Probable transposase; Region: OrfB_IS605; pfam01385 1279365013741 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1279365013742 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1279365013743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1279365013744 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1279365013745 Probable transposase; Region: OrfB_IS605; pfam01385 1279365013746 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1279365013747 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1279365013748 catalytic residues [active] 1279365013749 catalytic nucleophile [active] 1279365013750 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1279365013751 DNA binding residues [nucleotide binding] 1279365013752 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1279365013753 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1279365013754 acyl-activating enzyme (AAE) consensus motif; other site 1279365013755 putative active site [active] 1279365013756 putative AMP binding site [chemical binding]; other site 1279365013757 putative CoA binding site [chemical binding]; other site 1279365013758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1279365013759 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1279365013760 substrate binding site [chemical binding]; other site 1279365013761 oxyanion hole (OAH) forming residues; other site 1279365013762 trimer interface [polypeptide binding]; other site 1279365013763 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1279365013764 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1279365013765 nucleophilic elbow; other site 1279365013766 catalytic triad; other site 1279365013767 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1279365013768 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1279365013769 dimer interface [polypeptide binding]; other site 1279365013770 tetramer interface [polypeptide binding]; other site 1279365013771 PYR/PP interface [polypeptide binding]; other site 1279365013772 TPP binding site [chemical binding]; other site 1279365013773 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1279365013774 TPP-binding site; other site 1279365013775 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1279365013776 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1279365013777 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1279365013778 UbiA prenyltransferase family; Region: UbiA; pfam01040 1279365013779 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1279365013780 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1279365013781 DNA-binding site [nucleotide binding]; DNA binding site 1279365013782 RNA-binding motif; other site 1279365013783 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1279365013784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365013785 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365013786 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1279365013787 active site flap/lid [active] 1279365013788 nucleophilic elbow; other site 1279365013789 catalytic triad [active] 1279365013790 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1279365013791 homodimer interface [polypeptide binding]; other site 1279365013792 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1279365013793 active site pocket [active] 1279365013794 glycogen synthase; Provisional; Region: glgA; PRK00654 1279365013795 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1279365013796 ADP-binding pocket [chemical binding]; other site 1279365013797 homodimer interface [polypeptide binding]; other site 1279365013798 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1279365013799 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1279365013800 ligand binding site; other site 1279365013801 oligomer interface; other site 1279365013802 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1279365013803 dimer interface [polypeptide binding]; other site 1279365013804 N-terminal domain interface [polypeptide binding]; other site 1279365013805 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1279365013806 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1279365013807 ligand binding site; other site 1279365013808 oligomer interface; other site 1279365013809 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1279365013810 dimer interface [polypeptide binding]; other site 1279365013811 N-terminal domain interface [polypeptide binding]; other site 1279365013812 sulfate 1 binding site; other site 1279365013813 glycogen branching enzyme; Provisional; Region: PRK12313 1279365013814 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1279365013815 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1279365013816 active site 1279365013817 catalytic site [active] 1279365013818 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1279365013819 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1279365013820 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1279365013821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365013822 NAD binding site [chemical binding]; other site 1279365013823 dimer interface [polypeptide binding]; other site 1279365013824 substrate binding site [chemical binding]; other site 1279365013825 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1279365013826 MgtC family; Region: MgtC; pfam02308 1279365013827 Ion channel; Region: Ion_trans_2; pfam07885 1279365013828 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1279365013829 TrkA-N domain; Region: TrkA_N; pfam02254 1279365013830 YugN-like family; Region: YugN; pfam08868 1279365013831 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1279365013832 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1279365013833 active site 1279365013834 dimer interface [polypeptide binding]; other site 1279365013835 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1279365013836 dimer interface [polypeptide binding]; other site 1279365013837 active site 1279365013838 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1279365013839 general stress protein 13; Validated; Region: PRK08059 1279365013840 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1279365013841 RNA binding site [nucleotide binding]; other site 1279365013842 hypothetical protein; Validated; Region: PRK07682 1279365013843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365013844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365013845 homodimer interface [polypeptide binding]; other site 1279365013846 catalytic residue [active] 1279365013847 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1279365013848 AsnC family; Region: AsnC_trans_reg; pfam01037 1279365013849 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1279365013850 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1279365013851 dimerization interface [polypeptide binding]; other site 1279365013852 ligand binding site [chemical binding]; other site 1279365013853 NADP binding site [chemical binding]; other site 1279365013854 catalytic site [active] 1279365013855 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1279365013856 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365013857 nucleophilic elbow; other site 1279365013858 catalytic triad; other site 1279365013859 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1279365013860 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1279365013861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1279365013862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365013863 homodimer interface [polypeptide binding]; other site 1279365013864 catalytic residue [active] 1279365013865 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1279365013866 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1279365013867 E-class dimer interface [polypeptide binding]; other site 1279365013868 P-class dimer interface [polypeptide binding]; other site 1279365013869 active site 1279365013870 Cu2+ binding site [ion binding]; other site 1279365013871 Zn2+ binding site [ion binding]; other site 1279365013872 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1279365013873 Kinase associated protein B; Region: KapB; pfam08810 1279365013874 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1279365013875 active site 1279365013876 catalytic site [active] 1279365013877 substrate binding site [chemical binding]; other site 1279365013878 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1279365013879 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1279365013880 transmembrane helices; other site 1279365013881 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1279365013882 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1279365013883 active site 1279365013884 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1279365013885 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1279365013886 motif 1; other site 1279365013887 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1279365013888 active site 1279365013889 motif 2; other site 1279365013890 motif 3; other site 1279365013891 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1279365013892 anticodon binding site; other site 1279365013893 putative transposase OrfB; Reviewed; Region: PHA02517 1279365013894 HTH-like domain; Region: HTH_21; pfam13276 1279365013895 Integrase core domain; Region: rve; pfam00665 1279365013896 Integrase core domain; Region: rve_2; pfam13333 1279365013897 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1279365013898 CoenzymeA binding site [chemical binding]; other site 1279365013899 subunit interaction site [polypeptide binding]; other site 1279365013900 PHB binding site; other site 1279365013901 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1279365013902 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1279365013903 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1279365013904 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1279365013905 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1279365013906 active site 1279365013907 tetramer interface; other site 1279365013908 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1279365013909 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1279365013910 active site 1279365013911 substrate binding site [chemical binding]; other site 1279365013912 metal binding site [ion binding]; metal-binding site 1279365013913 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1279365013914 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1279365013915 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1279365013916 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1279365013917 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1279365013918 interface (dimer of trimers) [polypeptide binding]; other site 1279365013919 Substrate-binding/catalytic site; other site 1279365013920 Zn-binding sites [ion binding]; other site 1279365013921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1279365013922 Putative membrane protein; Region: YuiB; pfam14068 1279365013923 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1279365013924 nudix motif; other site 1279365013925 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1279365013926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365013927 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1279365013928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365013929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365013930 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013931 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013932 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013933 Domain of unknown function DUF11; Region: DUF11; cl17728 1279365013934 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365013935 Domain of unknown function DUF11; Region: DUF11; pfam01345 1279365013936 Domain of unknown function DUF11; Region: DUF11; cl17728 1279365013937 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365013938 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1279365013939 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013940 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013941 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013942 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013943 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013944 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1279365013945 Domain of unknown function DUF11; Region: DUF11; pfam01345 1279365013946 Domain of unknown function DUF11; Region: DUF11; pfam01345 1279365013947 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1279365013948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1279365013949 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365013950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365013951 putative substrate translocation pore; other site 1279365013952 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365013953 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1279365013954 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1279365013955 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365013956 Replication-relaxation; Region: Replic_Relax; pfam13814 1279365013957 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1279365013958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365013959 non-specific DNA binding site [nucleotide binding]; other site 1279365013960 salt bridge; other site 1279365013961 sequence-specific DNA binding site [nucleotide binding]; other site 1279365013962 hypothetical protein; Region: PHA02436 1279365013963 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365013964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365013965 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365013966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365013967 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365013968 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365013969 HTH-like domain; Region: HTH_21; pfam13276 1279365013970 Integrase core domain; Region: rve; pfam00665 1279365013971 Integrase core domain; Region: rve_2; pfam13333 1279365013972 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365013973 amidase catalytic site [active] 1279365013974 Zn binding residues [ion binding]; other site 1279365013975 substrate binding site [chemical binding]; other site 1279365013976 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365013977 Holin family; Region: Phage_holin_4; pfam05105 1279365013978 Haemolysin XhlA; Region: XhlA; pfam10779 1279365013979 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365013980 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 1279365013981 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1279365013982 Phage tail protein; Region: Sipho_tail; pfam05709 1279365013983 Phage tail protein; Region: Sipho_tail; cl17486 1279365013984 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1279365013985 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365013986 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1279365013987 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1279365013988 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1279365013989 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1279365013990 oligomerization interface [polypeptide binding]; other site 1279365013991 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365013992 Phage capsid family; Region: Phage_capsid; pfam05065 1279365013993 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1279365013994 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1279365013995 oligomer interface [polypeptide binding]; other site 1279365013996 active site residues [active] 1279365013997 Phage-related protein [Function unknown]; Region: COG4695 1279365013998 Phage portal protein; Region: Phage_portal; pfam04860 1279365013999 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365014000 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1279365014001 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1279365014002 HNH endonuclease; Region: HNH; pfam01844 1279365014003 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1279365014004 Int/Topo IB signature motif; other site 1279365014005 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1279365014006 YjcQ protein; Region: YjcQ; pfam09639 1279365014007 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1279365014008 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 1279365014009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1279365014010 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 1279365014011 phosphoinositide binding site [chemical binding]; other site 1279365014012 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1279365014013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365014014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365014015 DNA binding residues [nucleotide binding] 1279365014016 ORF6C domain; Region: ORF6C; pfam10552 1279365014017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365014018 salt bridge; other site 1279365014019 non-specific DNA binding site [nucleotide binding]; other site 1279365014020 sequence-specific DNA binding site [nucleotide binding]; other site 1279365014021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365014022 non-specific DNA binding site [nucleotide binding]; other site 1279365014023 salt bridge; other site 1279365014024 sequence-specific DNA binding site [nucleotide binding]; other site 1279365014025 integrase; Provisional; Region: int; PHA02601 1279365014026 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1279365014027 Int/Topo IB signature motif; other site 1279365014028 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1279365014029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365014030 Transposase; Region: HTH_Tnp_1; cl17663 1279365014031 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365014032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1279365014033 HTH-like domain; Region: HTH_21; pfam13276 1279365014034 Integrase core domain; Region: rve; pfam00665 1279365014035 Integrase core domain; Region: rve_2; pfam13333 1279365014036 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1279365014037 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1279365014038 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1279365014039 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1279365014040 hypothetical protein; Provisional; Region: PRK13669 1279365014041 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1279365014042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365014043 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1279365014044 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365014045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365014046 Walker A/P-loop; other site 1279365014047 ATP binding site [chemical binding]; other site 1279365014048 Q-loop/lid; other site 1279365014049 ABC transporter signature motif; other site 1279365014050 Walker B; other site 1279365014051 D-loop; other site 1279365014052 H-loop/switch region; other site 1279365014053 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1279365014054 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1279365014055 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1279365014056 PhnA protein; Region: PhnA; pfam03831 1279365014057 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1279365014058 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1279365014059 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1279365014060 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1279365014061 active site 1279365014062 NTP binding site [chemical binding]; other site 1279365014063 metal binding triad [ion binding]; metal-binding site 1279365014064 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1279365014065 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1279365014066 NifU-like domain; Region: NifU; pfam01106 1279365014067 spore coat protein YutH; Region: spore_yutH; TIGR02905 1279365014068 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1279365014069 tetramer interfaces [polypeptide binding]; other site 1279365014070 binuclear metal-binding site [ion binding]; other site 1279365014071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365014072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365014073 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1279365014074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365014075 active site 1279365014076 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1279365014077 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1279365014078 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1279365014079 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1279365014080 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1279365014081 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1279365014082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365014083 active site 1279365014084 motif I; other site 1279365014085 motif II; other site 1279365014086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365014087 Predicted transcriptional regulator [Transcription]; Region: COG2345 1279365014088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365014089 putative Zn2+ binding site [ion binding]; other site 1279365014090 putative DNA binding site [nucleotide binding]; other site 1279365014091 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1279365014092 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1279365014093 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1279365014094 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1279365014095 putative active site [active] 1279365014096 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1279365014097 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1279365014098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365014099 RNA binding surface [nucleotide binding]; other site 1279365014100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1279365014101 Coenzyme A binding pocket [chemical binding]; other site 1279365014102 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1279365014103 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1279365014104 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1279365014105 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1279365014106 DNA binding residues [nucleotide binding] 1279365014107 dimer interface [polypeptide binding]; other site 1279365014108 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1279365014109 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1279365014110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1279365014111 catalytic core [active] 1279365014112 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1279365014113 putative deacylase active site [active] 1279365014114 lipoyl synthase; Provisional; Region: PRK05481 1279365014115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1279365014116 FeS/SAM binding site; other site 1279365014117 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365014118 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365014119 sporulation protein YunB; Region: spo_yunB; TIGR02832 1279365014120 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1279365014121 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1279365014122 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1279365014123 active site 1279365014124 metal binding site [ion binding]; metal-binding site 1279365014125 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1279365014126 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1279365014127 FeS assembly protein SufB; Region: sufB; TIGR01980 1279365014128 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1279365014129 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1279365014130 trimerization site [polypeptide binding]; other site 1279365014131 active site 1279365014132 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1279365014133 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1279365014134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1279365014135 catalytic residue [active] 1279365014136 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1279365014137 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1279365014138 FeS assembly protein SufD; Region: sufD; TIGR01981 1279365014139 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1279365014140 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1279365014141 Walker A/P-loop; other site 1279365014142 ATP binding site [chemical binding]; other site 1279365014143 Q-loop/lid; other site 1279365014144 ABC transporter signature motif; other site 1279365014145 Walker B; other site 1279365014146 D-loop; other site 1279365014147 H-loop/switch region; other site 1279365014148 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1279365014149 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1279365014150 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1279365014151 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1279365014152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1279365014153 ABC-ATPase subunit interface; other site 1279365014154 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1279365014155 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1279365014156 Walker A/P-loop; other site 1279365014157 ATP binding site [chemical binding]; other site 1279365014158 Q-loop/lid; other site 1279365014159 ABC transporter signature motif; other site 1279365014160 Walker B; other site 1279365014161 D-loop; other site 1279365014162 H-loop/switch region; other site 1279365014163 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1279365014164 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1279365014165 catalytic residues [active] 1279365014166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1279365014167 putative active site [active] 1279365014168 putative metal binding site [ion binding]; other site 1279365014169 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1279365014170 lipoyl attachment site [posttranslational modification]; other site 1279365014171 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1279365014172 ArsC family; Region: ArsC; pfam03960 1279365014173 putative ArsC-like catalytic residues; other site 1279365014174 putative TRX-like catalytic residues [active] 1279365014175 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1279365014176 active site 1279365014177 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1279365014178 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1279365014179 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1279365014180 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1279365014181 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365014182 NAD binding site [chemical binding]; other site 1279365014183 dimer interface [polypeptide binding]; other site 1279365014184 substrate binding site [chemical binding]; other site 1279365014185 Coat F domain; Region: Coat_F; pfam07875 1279365014186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365014187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365014188 WHG domain; Region: WHG; pfam13305 1279365014189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1279365014190 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1279365014191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1279365014192 active site 1279365014193 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1279365014194 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1279365014195 dimer interface [polypeptide binding]; other site 1279365014196 active site 1279365014197 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1279365014198 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1279365014199 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1279365014200 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1279365014201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1279365014202 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1279365014203 substrate binding site [chemical binding]; other site 1279365014204 oxyanion hole (OAH) forming residues; other site 1279365014205 YuzL-like protein; Region: YuzL; pfam14115 1279365014206 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365014207 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1279365014208 Proline dehydrogenase; Region: Pro_dh; cl03282 1279365014209 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1279365014210 Domain of unknown function DUF77; Region: DUF77; pfam01910 1279365014211 Cache domain; Region: Cache_1; pfam02743 1279365014212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365014213 dimerization interface [polypeptide binding]; other site 1279365014214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365014215 dimer interface [polypeptide binding]; other site 1279365014216 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365014217 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365014218 dimer interface [polypeptide binding]; other site 1279365014219 putative CheW interface [polypeptide binding]; other site 1279365014220 Predicted transcriptional regulators [Transcription]; Region: COG1378 1279365014221 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1279365014222 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1279365014223 C-terminal domain interface [polypeptide binding]; other site 1279365014224 sugar binding site [chemical binding]; other site 1279365014225 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1279365014226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365014227 putative substrate translocation pore; other site 1279365014228 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1279365014229 Spore germination protein; Region: Spore_permease; cl17796 1279365014230 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1279365014231 OxaA-like protein precursor; Validated; Region: PRK01622 1279365014232 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1279365014233 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365014234 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1279365014235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1279365014236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365014237 hypothetical protein; Provisional; Region: PRK06758 1279365014238 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1279365014239 active site 1279365014240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365014241 non-specific DNA binding site [nucleotide binding]; other site 1279365014242 salt bridge; other site 1279365014243 sequence-specific DNA binding site [nucleotide binding]; other site 1279365014244 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365014245 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365014246 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 1279365014247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1279365014248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1279365014249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365014250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365014251 active site 1279365014252 phosphorylation site [posttranslational modification] 1279365014253 intermolecular recognition site; other site 1279365014254 dimerization interface [polypeptide binding]; other site 1279365014255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365014256 DNA binding site [nucleotide binding] 1279365014257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365014258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365014259 dimer interface [polypeptide binding]; other site 1279365014260 phosphorylation site [posttranslational modification] 1279365014261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365014262 ATP binding site [chemical binding]; other site 1279365014263 Mg2+ binding site [ion binding]; other site 1279365014264 G-X-G motif; other site 1279365014265 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1279365014266 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1279365014267 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1279365014268 active site 1279365014269 HIGH motif; other site 1279365014270 KMSKS motif; other site 1279365014271 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1279365014272 tRNA binding surface [nucleotide binding]; other site 1279365014273 anticodon binding site; other site 1279365014274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365014275 S-adenosylmethionine binding site [chemical binding]; other site 1279365014276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365014277 dimerization interface [polypeptide binding]; other site 1279365014278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365014279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365014280 dimer interface [polypeptide binding]; other site 1279365014281 putative CheW interface [polypeptide binding]; other site 1279365014282 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1279365014283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365014284 dimerization interface [polypeptide binding]; other site 1279365014285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365014286 dimer interface [polypeptide binding]; other site 1279365014287 putative CheW interface [polypeptide binding]; other site 1279365014288 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1279365014289 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365014290 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365014291 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1279365014292 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1279365014293 active site 1279365014294 Zn binding site [ion binding]; other site 1279365014295 Pirin-related protein [General function prediction only]; Region: COG1741 1279365014296 Pirin; Region: Pirin; pfam02678 1279365014297 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1279365014298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1279365014299 MarR family; Region: MarR_2; pfam12802 1279365014300 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 1279365014301 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1279365014302 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1279365014303 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1279365014304 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365014305 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1279365014306 TrkA-C domain; Region: TrkA_C; pfam02080 1279365014307 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365014308 amino acid carrier protein; Region: agcS; TIGR00835 1279365014309 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1279365014310 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1279365014311 dimerization interface [polypeptide binding]; other site 1279365014312 DPS ferroxidase diiron center [ion binding]; other site 1279365014313 ion pore; other site 1279365014314 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1279365014315 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1279365014316 metal binding site [ion binding]; metal-binding site 1279365014317 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1279365014318 Ferritin-like domain; Region: Ferritin; pfam00210 1279365014319 ferroxidase diiron center [ion binding]; other site 1279365014320 Predicted membrane protein [Function unknown]; Region: COG2311 1279365014321 Protein of unknown function (DUF418); Region: DUF418; cl12135 1279365014322 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1279365014323 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365014324 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365014325 Nucleoside recognition; Region: Gate; pfam07670 1279365014326 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365014327 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365014328 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365014329 Nucleoside recognition; Region: Gate; pfam07670 1279365014330 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365014331 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365014332 amino acid carrier protein; Region: agcS; TIGR00835 1279365014333 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1279365014334 amino acid carrier protein; Region: agcS; TIGR00835 1279365014335 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1279365014336 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1279365014337 NAD binding site [chemical binding]; other site 1279365014338 substrate binding site [chemical binding]; other site 1279365014339 putative active site [active] 1279365014340 Peptidase M60-like family; Region: M60-like; pfam13402 1279365014341 TQXA domain; Region: TQXA_dom; TIGR03934 1279365014342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1279365014343 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1279365014344 active site 1279365014345 catalytic tetrad [active] 1279365014346 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1279365014347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365014348 putative substrate translocation pore; other site 1279365014349 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365014350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365014351 dimerization interface [polypeptide binding]; other site 1279365014352 putative DNA binding site [nucleotide binding]; other site 1279365014353 putative Zn2+ binding site [ion binding]; other site 1279365014354 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1279365014355 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1279365014356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365014357 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1279365014358 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1279365014359 active site 1279365014360 HIGH motif; other site 1279365014361 dimer interface [polypeptide binding]; other site 1279365014362 KMSKS motif; other site 1279365014363 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1279365014364 RNA binding surface [nucleotide binding]; other site 1279365014365 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 1279365014366 FAD binding domain; Region: FAD_binding_4; pfam01565 1279365014367 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1279365014368 SET domain; Region: SET; pfam00856 1279365014369 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 1279365014370 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365014371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365014372 dimer interface [polypeptide binding]; other site 1279365014373 putative CheW interface [polypeptide binding]; other site 1279365014374 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1279365014375 putative phosphate binding site [ion binding]; other site 1279365014376 camphor resistance protein CrcB; Provisional; Region: PRK14219 1279365014377 camphor resistance protein CrcB; Provisional; Region: PRK14205 1279365014378 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 1279365014379 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1279365014380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365014381 H+ Antiporter protein; Region: 2A0121; TIGR00900 1279365014382 putative substrate translocation pore; other site 1279365014383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365014384 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365014385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365014386 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365014387 ABC transporter; Region: ABC_tran_2; pfam12848 1279365014388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365014389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1279365014390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1279365014391 Coenzyme A binding pocket [chemical binding]; other site 1279365014392 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1279365014393 Nuclease-related domain; Region: NERD; pfam08378 1279365014394 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1279365014395 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1279365014396 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1279365014397 Walker A/P-loop; other site 1279365014398 ATP binding site [chemical binding]; other site 1279365014399 Q-loop/lid; other site 1279365014400 ABC transporter signature motif; other site 1279365014401 Walker B; other site 1279365014402 D-loop; other site 1279365014403 H-loop/switch region; other site 1279365014404 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365014405 ABC-ATPase subunit interface; other site 1279365014406 dimer interface [polypeptide binding]; other site 1279365014407 putative PBP binding regions; other site 1279365014408 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1279365014409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365014410 ABC-ATPase subunit interface; other site 1279365014411 dimer interface [polypeptide binding]; other site 1279365014412 putative PBP binding regions; other site 1279365014413 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1279365014414 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1279365014415 putative ligand binding residues [chemical binding]; other site 1279365014416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365014417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365014418 active site 1279365014419 phosphorylation site [posttranslational modification] 1279365014420 intermolecular recognition site; other site 1279365014421 dimerization interface [polypeptide binding]; other site 1279365014422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365014423 DNA binding site [nucleotide binding] 1279365014424 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365014425 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365014426 putative active site [active] 1279365014427 putative NTP binding site [chemical binding]; other site 1279365014428 putative nucleic acid binding site [nucleotide binding]; other site 1279365014429 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365014430 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365014431 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1279365014432 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1279365014433 SmpB-tmRNA interface; other site 1279365014434 ribonuclease R; Region: RNase_R; TIGR02063 1279365014435 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1279365014436 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1279365014437 RNB domain; Region: RNB; pfam00773 1279365014438 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1279365014439 RNA binding site [nucleotide binding]; other site 1279365014440 Esterase/lipase [General function prediction only]; Region: COG1647 1279365014441 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1279365014442 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1279365014443 holin-like protein; Validated; Region: PRK01658 1279365014444 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 1279365014445 active site 1279365014446 enolase; Provisional; Region: eno; PRK00077 1279365014447 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1279365014448 dimer interface [polypeptide binding]; other site 1279365014449 metal binding site [ion binding]; metal-binding site 1279365014450 substrate binding pocket [chemical binding]; other site 1279365014451 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1279365014452 phosphoglyceromutase; Provisional; Region: PRK05434 1279365014453 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1279365014454 triosephosphate isomerase; Provisional; Region: PRK14565 1279365014455 substrate binding site [chemical binding]; other site 1279365014456 dimer interface [polypeptide binding]; other site 1279365014457 catalytic triad [active] 1279365014458 Phosphoglycerate kinase; Region: PGK; pfam00162 1279365014459 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1279365014460 substrate binding site [chemical binding]; other site 1279365014461 hinge regions; other site 1279365014462 ADP binding site [chemical binding]; other site 1279365014463 catalytic site [active] 1279365014464 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1279365014465 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1279365014466 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1279365014467 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1279365014468 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1279365014469 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1279365014470 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1279365014471 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1279365014472 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1279365014473 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1279365014474 Helix-turn-helix domain; Region: HTH_36; pfam13730 1279365014475 WYL domain; Region: WYL; cl14852 1279365014476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1279365014477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365014478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365014479 TPR motif; other site 1279365014480 binding surface 1279365014481 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365014482 amidase catalytic site [active] 1279365014483 Zn binding residues [ion binding]; other site 1279365014484 substrate binding site [chemical binding]; other site 1279365014485 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014486 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014487 Holin family; Region: Phage_holin_4; pfam05105 1279365014488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365014489 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365014490 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365014491 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1279365014492 Laminin Domain II; Region: Laminin_II; pfam06009 1279365014493 Phage tail protein; Region: Sipho_tail; pfam05709 1279365014494 Phage tail protein; Region: Sipho_tail; cl17486 1279365014495 Phage-related protein [Function unknown]; Region: COG5412 1279365014496 membrane protein P6; Region: PHA01399 1279365014497 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 1279365014498 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1279365014499 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1279365014500 Protein of unknown function (DUF2578); Region: DUF2578; pfam10843 1279365014501 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1279365014502 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1279365014503 oligomer interface [polypeptide binding]; other site 1279365014504 active site residues [active] 1279365014505 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1279365014506 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1279365014507 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1279365014508 Phage terminase, small subunit; Region: Terminase_4; cl01525 1279365014509 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1279365014510 HNH endonuclease; Region: HNH; pfam01844 1279365014511 active site 1279365014512 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 1279365014513 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1279365014514 Recombination protein U; Region: RecU; pfam03838 1279365014515 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1279365014516 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1279365014517 galactokinase; Region: PLN02865 1279365014518 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1279365014519 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1279365014520 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1279365014521 ORF6C domain; Region: ORF6C; pfam10552 1279365014522 Domain of unknown function (DUF771); Region: DUF771; cl09962 1279365014523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365014524 non-specific DNA binding site [nucleotide binding]; other site 1279365014525 salt bridge; other site 1279365014526 sequence-specific DNA binding site [nucleotide binding]; other site 1279365014527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365014528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365014529 non-specific DNA binding site [nucleotide binding]; other site 1279365014530 salt bridge; other site 1279365014531 sequence-specific DNA binding site [nucleotide binding]; other site 1279365014532 Domain of unknown function (DUF955); Region: DUF955; cl01076 1279365014533 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1279365014534 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1279365014535 Int/Topo IB signature motif; other site 1279365014536 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1279365014537 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1279365014538 stage V sporulation protein AD; Provisional; Region: PRK12404 1279365014539 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1279365014540 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1279365014541 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1279365014542 Predicted membrane protein [Function unknown]; Region: COG2323 1279365014543 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1279365014544 Clp protease; Region: CLP_protease; pfam00574 1279365014545 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1279365014546 oligomer interface [polypeptide binding]; other site 1279365014547 active site residues [active] 1279365014548 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1279365014549 dimerization domain swap beta strand [polypeptide binding]; other site 1279365014550 regulatory protein interface [polypeptide binding]; other site 1279365014551 active site 1279365014552 regulatory phosphorylation site [posttranslational modification]; other site 1279365014553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1279365014554 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1279365014555 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1279365014556 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1279365014557 phosphate binding site [ion binding]; other site 1279365014558 putative substrate binding pocket [chemical binding]; other site 1279365014559 dimer interface [polypeptide binding]; other site 1279365014560 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1279365014561 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1279365014562 putative active site [active] 1279365014563 nucleotide binding site [chemical binding]; other site 1279365014564 nudix motif; other site 1279365014565 putative metal binding site [ion binding]; other site 1279365014566 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1279365014567 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1279365014568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1279365014569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1279365014570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365014571 binding surface 1279365014572 TPR motif; other site 1279365014573 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365014574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365014575 binding surface 1279365014576 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1279365014577 TPR motif; other site 1279365014578 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1279365014579 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1279365014580 trimer interface [polypeptide binding]; other site 1279365014581 active site 1279365014582 substrate binding site [chemical binding]; other site 1279365014583 CoA binding site [chemical binding]; other site 1279365014584 pyrophosphatase PpaX; Provisional; Region: PRK13288 1279365014585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365014586 active site 1279365014587 motif I; other site 1279365014588 motif II; other site 1279365014589 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1279365014590 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1279365014591 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1279365014592 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1279365014593 Hpr binding site; other site 1279365014594 active site 1279365014595 homohexamer subunit interaction site [polypeptide binding]; other site 1279365014596 Predicted membrane protein [Function unknown]; Region: COG1950 1279365014597 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 1279365014598 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1279365014599 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1279365014600 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1279365014601 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1279365014602 excinuclease ABC subunit B; Provisional; Region: PRK05298 1279365014603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365014604 ATP binding site [chemical binding]; other site 1279365014605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365014606 nucleotide binding region [chemical binding]; other site 1279365014607 ATP-binding site [chemical binding]; other site 1279365014608 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1279365014609 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 1279365014610 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1279365014611 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365014612 DNA binding residues [nucleotide binding] 1279365014613 dimer interface [polypeptide binding]; other site 1279365014614 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1279365014615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365014616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365014617 non-specific DNA binding site [nucleotide binding]; other site 1279365014618 salt bridge; other site 1279365014619 sequence-specific DNA binding site [nucleotide binding]; other site 1279365014620 Predicted membrane protein [Function unknown]; Region: COG2855 1279365014621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365014622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365014623 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1279365014624 putative dimerization interface [polypeptide binding]; other site 1279365014625 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1279365014626 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365014627 DNA binding residues [nucleotide binding] 1279365014628 putative dimer interface [polypeptide binding]; other site 1279365014629 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1279365014630 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1279365014631 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365014632 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365014633 ABC transporter; Region: ABC_tran_2; pfam12848 1279365014634 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365014635 hypothetical protein; Provisional; Region: PRK12855 1279365014636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1279365014637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1279365014638 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1279365014639 Walker A/P-loop; other site 1279365014640 ATP binding site [chemical binding]; other site 1279365014641 Q-loop/lid; other site 1279365014642 ABC transporter signature motif; other site 1279365014643 Walker B; other site 1279365014644 D-loop; other site 1279365014645 H-loop/switch region; other site 1279365014646 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1279365014647 protein binding site [polypeptide binding]; other site 1279365014648 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1279365014649 C-terminal peptidase (prc); Region: prc; TIGR00225 1279365014650 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1279365014651 protein binding site [polypeptide binding]; other site 1279365014652 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1279365014653 Catalytic dyad [active] 1279365014654 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1279365014655 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1279365014656 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1279365014657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365014658 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1279365014659 Walker A/P-loop; other site 1279365014660 ATP binding site [chemical binding]; other site 1279365014661 Q-loop/lid; other site 1279365014662 ABC transporter signature motif; other site 1279365014663 Walker B; other site 1279365014664 D-loop; other site 1279365014665 H-loop/switch region; other site 1279365014666 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1279365014667 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1279365014668 peptide chain release factor 2; Provisional; Region: PRK06746 1279365014669 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1279365014670 RF-1 domain; Region: RF-1; pfam00472 1279365014671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1279365014672 nucleotide binding region [chemical binding]; other site 1279365014673 ATP-binding site [chemical binding]; other site 1279365014674 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1279365014675 SEC-C motif; Region: SEC-C; pfam02810 1279365014676 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1279365014677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365014678 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1279365014679 Walker A/P-loop; other site 1279365014680 ATP binding site [chemical binding]; other site 1279365014681 Q-loop/lid; other site 1279365014682 ABC transporter signature motif; other site 1279365014683 Walker B; other site 1279365014684 D-loop; other site 1279365014685 H-loop/switch region; other site 1279365014686 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1279365014687 30S subunit binding site; other site 1279365014688 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1279365014689 DNA-binding site [nucleotide binding]; DNA binding site 1279365014690 RNA-binding motif; other site 1279365014691 comF family protein; Region: comF; TIGR00201 1279365014692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365014693 active site 1279365014694 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1279365014695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365014696 ATP binding site [chemical binding]; other site 1279365014697 putative Mg++ binding site [ion binding]; other site 1279365014698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365014699 nucleotide binding region [chemical binding]; other site 1279365014700 ATP-binding site [chemical binding]; other site 1279365014701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1279365014702 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1279365014703 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1279365014704 NlpC/P60 family; Region: NLPC_P60; pfam00877 1279365014705 Predicted transcriptional regulators [Transcription]; Region: COG1733 1279365014706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365014707 dimerization interface [polypeptide binding]; other site 1279365014708 putative DNA binding site [nucleotide binding]; other site 1279365014709 putative Zn2+ binding site [ion binding]; other site 1279365014710 EDD domain protein, DegV family; Region: DegV; TIGR00762 1279365014711 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1279365014712 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1279365014713 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1279365014714 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1279365014715 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1279365014716 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1279365014717 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1279365014718 active site 1279365014719 homodimer interface [polypeptide binding]; other site 1279365014720 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1279365014721 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1279365014722 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1279365014723 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1279365014724 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1279365014725 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1279365014726 Mg++ binding site [ion binding]; other site 1279365014727 putative catalytic motif [active] 1279365014728 substrate binding site [chemical binding]; other site 1279365014729 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1279365014730 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1279365014731 NodB motif; other site 1279365014732 active site 1279365014733 catalytic site [active] 1279365014734 Zn binding site [ion binding]; other site 1279365014735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365014736 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1279365014737 Walker A motif; other site 1279365014738 ATP binding site [chemical binding]; other site 1279365014739 Walker B motif; other site 1279365014740 arginine finger; other site 1279365014741 Transcriptional antiterminator [Transcription]; Region: COG3933 1279365014742 PRD domain; Region: PRD; pfam00874 1279365014743 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1279365014744 active pocket/dimerization site; other site 1279365014745 active site 1279365014746 phosphorylation site [posttranslational modification] 1279365014747 PRD domain; Region: PRD; pfam00874 1279365014748 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 1279365014749 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1279365014750 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1279365014751 Chromate transporter; Region: Chromate_transp; pfam02417 1279365014752 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1279365014753 putative active site [active] 1279365014754 YdjC motif; other site 1279365014755 Mg binding site [ion binding]; other site 1279365014756 putative homodimer interface [polypeptide binding]; other site 1279365014757 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1279365014758 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1279365014759 NAD binding site [chemical binding]; other site 1279365014760 sugar binding site [chemical binding]; other site 1279365014761 divalent metal binding site [ion binding]; other site 1279365014762 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365014763 dimer interface [polypeptide binding]; other site 1279365014764 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1279365014765 active site 1279365014766 methionine cluster; other site 1279365014767 phosphorylation site [posttranslational modification] 1279365014768 metal binding site [ion binding]; metal-binding site 1279365014769 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1279365014770 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1279365014771 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1279365014772 active site 1279365014773 P-loop; other site 1279365014774 phosphorylation site [posttranslational modification] 1279365014775 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1279365014776 methionine cluster; other site 1279365014777 active site 1279365014778 phosphorylation site [posttranslational modification] 1279365014779 metal binding site [ion binding]; metal-binding site 1279365014780 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1279365014781 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1279365014782 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1279365014783 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1279365014784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1279365014785 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1279365014786 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1279365014787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1279365014788 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1279365014789 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1279365014790 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1279365014791 Predicted membrane protein [Function unknown]; Region: COG1511 1279365014792 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1279365014793 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1279365014794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1279365014795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1279365014796 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1279365014797 putative dimerization interface [polypeptide binding]; other site 1279365014798 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1279365014799 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1279365014800 arsenical pump membrane protein; Provisional; Region: PRK15445 1279365014801 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1279365014802 transmembrane helices; other site 1279365014803 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1279365014804 ThiC-associated domain; Region: ThiC-associated; pfam13667 1279365014805 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1279365014806 L-lactate permease; Region: Lactate_perm; cl00701 1279365014807 glycolate transporter; Provisional; Region: PRK09695 1279365014808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1279365014809 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1279365014810 Probable transposase; Region: OrfB_IS605; pfam01385 1279365014811 Tic20-like protein; Region: Tic20; pfam09685 1279365014812 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1279365014813 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1279365014814 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1279365014815 Sulfatase; Region: Sulfatase; pfam00884 1279365014816 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1279365014817 homodimer interface [polypeptide binding]; other site 1279365014818 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1279365014819 substrate-cofactor binding pocket; other site 1279365014820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365014821 catalytic residue [active] 1279365014822 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014823 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014824 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014825 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014826 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014827 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1279365014828 NlpC/P60 family; Region: NLPC_P60; pfam00877 1279365014829 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1279365014830 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1279365014831 Nucleoside recognition; Region: Gate; pfam07670 1279365014832 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1279365014833 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1279365014834 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1279365014835 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1279365014836 DXD motif; other site 1279365014837 BCCT family transporter; Region: BCCT; pfam02028 1279365014838 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014839 Bacterial SH3 domain; Region: SH3_3; pfam08239 1279365014840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1279365014841 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 1279365014842 Predicted membrane protein [Function unknown]; Region: COG4640 1279365014843 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1279365014844 Double zinc ribbon; Region: DZR; pfam12773 1279365014845 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1279365014846 Double zinc ribbon; Region: DZR; pfam12773 1279365014847 SNF2 Helicase protein; Region: DUF3670; pfam12419 1279365014848 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1279365014849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1279365014850 ATP binding site [chemical binding]; other site 1279365014851 putative Mg++ binding site [ion binding]; other site 1279365014852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365014853 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1279365014854 nucleotide binding region [chemical binding]; other site 1279365014855 ATP-binding site [chemical binding]; other site 1279365014856 Predicted integral membrane protein [Function unknown]; Region: COG5652 1279365014857 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 1279365014858 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1279365014859 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1279365014860 ComK protein; Region: ComK; cl11560 1279365014861 RNA polymerase factor sigma-70; Validated; Region: PRK06759 1279365014862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365014863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365014864 DNA binding residues [nucleotide binding] 1279365014865 Yip1 domain; Region: Yip1; cl17815 1279365014866 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1279365014867 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1279365014868 FtsX-like permease family; Region: FtsX; pfam02687 1279365014869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1279365014870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1279365014871 Walker A/P-loop; other site 1279365014872 ATP binding site [chemical binding]; other site 1279365014873 Q-loop/lid; other site 1279365014874 ABC transporter signature motif; other site 1279365014875 Walker B; other site 1279365014876 D-loop; other site 1279365014877 H-loop/switch region; other site 1279365014878 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1279365014879 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1279365014880 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1279365014881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365014882 putative substrate translocation pore; other site 1279365014883 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1279365014884 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1279365014885 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 1279365014886 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1279365014887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365014888 dimerization interface [polypeptide binding]; other site 1279365014889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365014890 dimer interface [polypeptide binding]; other site 1279365014891 phosphorylation site [posttranslational modification] 1279365014892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365014893 ATP binding site [chemical binding]; other site 1279365014894 Mg2+ binding site [ion binding]; other site 1279365014895 G-X-G motif; other site 1279365014896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365014897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365014898 active site 1279365014899 phosphorylation site [posttranslational modification] 1279365014900 intermolecular recognition site; other site 1279365014901 dimerization interface [polypeptide binding]; other site 1279365014902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365014903 DNA binding site [nucleotide binding] 1279365014904 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1279365014905 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1279365014906 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1279365014907 UDP-glucose 4-epimerase; Region: PLN02240 1279365014908 NAD binding site [chemical binding]; other site 1279365014909 homodimer interface [polypeptide binding]; other site 1279365014910 active site 1279365014911 substrate binding site [chemical binding]; other site 1279365014912 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1279365014913 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1279365014914 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1279365014915 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1279365014916 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1279365014917 active site 1279365014918 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1279365014919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1279365014920 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1279365014921 O-Antigen ligase; Region: Wzy_C; pfam04932 1279365014922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365014923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1279365014924 active site 1279365014925 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1279365014926 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1279365014927 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1279365014928 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1279365014929 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1279365014930 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1279365014931 active site 1279365014932 tetramer interface; other site 1279365014933 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1279365014934 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1279365014935 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1279365014936 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1279365014937 Chain length determinant protein; Region: Wzz; cl15801 1279365014938 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1279365014939 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1279365014940 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1279365014941 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1279365014942 MreB and similar proteins; Region: MreB_like; cd10225 1279365014943 nucleotide binding site [chemical binding]; other site 1279365014944 Mg binding site [ion binding]; other site 1279365014945 putative protofilament interaction site [polypeptide binding]; other site 1279365014946 RodZ interaction site [polypeptide binding]; other site 1279365014947 Stage III sporulation protein D; Region: SpoIIID; cl17560 1279365014948 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365014949 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365014950 CcmB protein; Region: CcmB; cl17444 1279365014951 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1279365014952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365014953 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365014954 Walker A/P-loop; other site 1279365014955 ATP binding site [chemical binding]; other site 1279365014956 Q-loop/lid; other site 1279365014957 ABC transporter signature motif; other site 1279365014958 Walker B; other site 1279365014959 D-loop; other site 1279365014960 H-loop/switch region; other site 1279365014961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1279365014962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1279365014963 Q-loop/lid; other site 1279365014964 ABC transporter signature motif; other site 1279365014965 Walker B; other site 1279365014966 D-loop; other site 1279365014967 H-loop/switch region; other site 1279365014968 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1279365014969 LytTr DNA-binding domain; Region: LytTR; pfam04397 1279365014970 Stage II sporulation protein; Region: SpoIID; pfam08486 1279365014971 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1279365014972 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1279365014973 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1279365014974 hinge; other site 1279365014975 active site 1279365014976 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1279365014977 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1279365014978 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1279365014979 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1279365014980 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1279365014981 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1279365014982 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1279365014983 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1279365014984 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1279365014985 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1279365014986 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1279365014987 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1279365014988 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1279365014989 4Fe-4S binding domain; Region: Fer4; cl02805 1279365014990 4Fe-4S binding domain; Region: Fer4; pfam00037 1279365014991 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1279365014992 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1279365014993 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 1279365014994 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1279365014995 NADH dehydrogenase subunit C; Validated; Region: PRK07735 1279365014996 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1279365014997 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1279365014998 NADH dehydrogenase subunit A; Validated; Region: PRK07756 1279365014999 PAS domain S-box; Region: sensory_box; TIGR00229 1279365015000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365015001 putative active site [active] 1279365015002 heme pocket [chemical binding]; other site 1279365015003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365015004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365015005 metal binding site [ion binding]; metal-binding site 1279365015006 active site 1279365015007 I-site; other site 1279365015008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365015009 Protein of unknown function (DUF975); Region: DUF975; cl10504 1279365015010 Protein of unknown function (DUF975); Region: DUF975; cl10504 1279365015011 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1279365015012 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1279365015013 gamma subunit interface [polypeptide binding]; other site 1279365015014 epsilon subunit interface [polypeptide binding]; other site 1279365015015 LBP interface [polypeptide binding]; other site 1279365015016 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1279365015017 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1279365015018 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1279365015019 alpha subunit interaction interface [polypeptide binding]; other site 1279365015020 Walker A motif; other site 1279365015021 ATP binding site [chemical binding]; other site 1279365015022 Walker B motif; other site 1279365015023 inhibitor binding site; inhibition site 1279365015024 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1279365015025 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1279365015026 core domain interface [polypeptide binding]; other site 1279365015027 delta subunit interface [polypeptide binding]; other site 1279365015028 epsilon subunit interface [polypeptide binding]; other site 1279365015029 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1279365015030 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1279365015031 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1279365015032 beta subunit interaction interface [polypeptide binding]; other site 1279365015033 Walker A motif; other site 1279365015034 ATP binding site [chemical binding]; other site 1279365015035 Walker B motif; other site 1279365015036 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1279365015037 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1279365015038 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1279365015039 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1279365015040 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1279365015041 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1279365015042 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1279365015043 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1279365015044 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1279365015045 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1279365015046 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 1279365015047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1279365015048 active site 1279365015049 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1279365015050 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1279365015051 dimer interface [polypeptide binding]; other site 1279365015052 active site 1279365015053 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1279365015054 folate binding site [chemical binding]; other site 1279365015055 hypothetical protein; Provisional; Region: PRK13690 1279365015056 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1279365015057 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1279365015058 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1279365015059 active site 1279365015060 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1279365015061 HPr interaction site; other site 1279365015062 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1279365015063 active site 1279365015064 phosphorylation site [posttranslational modification] 1279365015065 Predicted membrane protein [Function unknown]; Region: COG2259 1279365015066 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1279365015067 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 1279365015068 Predicted membrane protein [Function unknown]; Region: COG1971 1279365015069 Domain of unknown function DUF; Region: DUF204; pfam02659 1279365015070 Domain of unknown function DUF; Region: DUF204; pfam02659 1279365015071 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1279365015072 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1279365015073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1279365015074 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1279365015075 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1279365015076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365015077 S-adenosylmethionine binding site [chemical binding]; other site 1279365015078 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1279365015079 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1279365015080 RF-1 domain; Region: RF-1; pfam00472 1279365015081 thymidine kinase; Provisional; Region: PRK04296 1279365015082 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1279365015083 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1279365015084 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1279365015085 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1279365015086 RNA binding site [nucleotide binding]; other site 1279365015087 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1279365015088 multimer interface [polypeptide binding]; other site 1279365015089 Walker A motif; other site 1279365015090 ATP binding site [chemical binding]; other site 1279365015091 Walker B motif; other site 1279365015092 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1279365015093 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1279365015094 putative active site [active] 1279365015095 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1279365015096 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1279365015097 hinge; other site 1279365015098 active site 1279365015099 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1279365015100 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1279365015101 intersubunit interface [polypeptide binding]; other site 1279365015102 active site 1279365015103 zinc binding site [ion binding]; other site 1279365015104 Na+ binding site [ion binding]; other site 1279365015105 Response regulator receiver domain; Region: Response_reg; pfam00072 1279365015106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365015107 active site 1279365015108 phosphorylation site [posttranslational modification] 1279365015109 intermolecular recognition site; other site 1279365015110 dimerization interface [polypeptide binding]; other site 1279365015111 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1279365015112 CTP synthetase; Validated; Region: pyrG; PRK05380 1279365015113 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1279365015114 Catalytic site [active] 1279365015115 active site 1279365015116 UTP binding site [chemical binding]; other site 1279365015117 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1279365015118 active site 1279365015119 putative oxyanion hole; other site 1279365015120 catalytic triad [active] 1279365015121 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1279365015122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365015123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365015124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1279365015125 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1279365015126 FAD binding site [chemical binding]; other site 1279365015127 homotetramer interface [polypeptide binding]; other site 1279365015128 substrate binding pocket [chemical binding]; other site 1279365015129 catalytic base [active] 1279365015130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1279365015131 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1279365015132 FAD binding site [chemical binding]; other site 1279365015133 homotetramer interface [polypeptide binding]; other site 1279365015134 substrate binding pocket [chemical binding]; other site 1279365015135 catalytic base [active] 1279365015136 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1279365015137 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1279365015138 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1279365015139 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1279365015140 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1279365015141 dimer interface [polypeptide binding]; other site 1279365015142 active site 1279365015143 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1279365015144 4Fe-4S binding domain; Region: Fer4; cl02805 1279365015145 Cysteine-rich domain; Region: CCG; pfam02754 1279365015146 Cysteine-rich domain; Region: CCG; pfam02754 1279365015147 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1279365015148 PLD-like domain; Region: PLDc_2; pfam13091 1279365015149 putative active site [active] 1279365015150 catalytic site [active] 1279365015151 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1279365015152 PLD-like domain; Region: PLDc_2; pfam13091 1279365015153 putative active site [active] 1279365015154 catalytic site [active] 1279365015155 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365015156 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365015157 putative active site [active] 1279365015158 putative NTP binding site [chemical binding]; other site 1279365015159 putative nucleic acid binding site [nucleotide binding]; other site 1279365015160 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365015161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015162 UV-endonuclease UvdE; Region: UvdE; cl10036 1279365015163 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 1279365015164 PAS domain S-box; Region: sensory_box; TIGR00229 1279365015165 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365015166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365015167 metal binding site [ion binding]; metal-binding site 1279365015168 active site 1279365015169 I-site; other site 1279365015170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1279365015171 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 1279365015172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365015173 non-specific DNA binding site [nucleotide binding]; other site 1279365015174 salt bridge; other site 1279365015175 sequence-specific DNA binding site [nucleotide binding]; other site 1279365015176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365015177 TPR repeat; Region: TPR_11; pfam13414 1279365015178 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1279365015179 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1279365015180 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1279365015181 active site 1279365015182 Zn binding site [ion binding]; other site 1279365015183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365015184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365015185 active site 1279365015186 phosphorylation site [posttranslational modification] 1279365015187 intermolecular recognition site; other site 1279365015188 dimerization interface [polypeptide binding]; other site 1279365015189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365015190 DNA binding residues [nucleotide binding] 1279365015191 dimerization interface [polypeptide binding]; other site 1279365015192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365015193 Histidine kinase; Region: HisKA_3; pfam07730 1279365015194 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1279365015195 ATP binding site [chemical binding]; other site 1279365015196 Mg2+ binding site [ion binding]; other site 1279365015197 G-X-G motif; other site 1279365015198 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1279365015199 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1279365015200 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365015201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1279365015202 Walker A/P-loop; other site 1279365015203 ATP binding site [chemical binding]; other site 1279365015204 Q-loop/lid; other site 1279365015205 ABC transporter signature motif; other site 1279365015206 Walker B; other site 1279365015207 D-loop; other site 1279365015208 H-loop/switch region; other site 1279365015209 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1279365015210 active site 1279365015211 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1279365015212 Collagen binding domain; Region: Collagen_bind; pfam05737 1279365015213 Collagen binding domain; Region: Collagen_bind; pfam05737 1279365015214 Collagen binding domain; Region: Collagen_bind; pfam05737 1279365015215 Collagen binding domain; Region: Collagen_bind; pfam05737 1279365015216 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015217 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015218 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015219 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015220 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015221 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015222 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015223 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1279365015224 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015225 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015226 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015227 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015228 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015229 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1279365015230 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015231 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015232 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015233 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015234 Cna protein B-type domain; Region: Cna_B; pfam05738 1279365015235 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1279365015236 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1279365015237 PA/protease or protease-like domain interface [polypeptide binding]; other site 1279365015238 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1279365015239 Peptidase family M28; Region: Peptidase_M28; pfam04389 1279365015240 metal binding site [ion binding]; metal-binding site 1279365015241 putative transposase OrfB; Reviewed; Region: PHA02517 1279365015242 HTH-like domain; Region: HTH_21; pfam13276 1279365015243 Integrase core domain; Region: rve; pfam00665 1279365015244 Integrase core domain; Region: rve_2; pfam13333 1279365015245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1279365015246 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365015247 Helix-turn-helix domain; Region: HTH_28; pfam13518 1279365015248 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 1279365015249 RNA polymerase sigma factor; Provisional; Region: PRK12522 1279365015250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1279365015251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1279365015252 DNA binding residues [nucleotide binding] 1279365015253 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1279365015254 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1279365015255 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1279365015256 active site 1279365015257 HIGH motif; other site 1279365015258 KMSK motif region; other site 1279365015259 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1279365015260 tRNA binding surface [nucleotide binding]; other site 1279365015261 anticodon binding site; other site 1279365015262 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1279365015263 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1279365015264 putative dimer interface [polypeptide binding]; other site 1279365015265 catalytic triad [active] 1279365015266 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1279365015267 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1279365015268 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1279365015269 agmatinase; Region: agmatinase; TIGR01230 1279365015270 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1279365015271 putative active site [active] 1279365015272 Mn binding site [ion binding]; other site 1279365015273 spermidine synthase; Provisional; Region: PRK00811 1279365015274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365015275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365015276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1279365015277 putative substrate translocation pore; other site 1279365015278 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1279365015279 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1279365015280 DNA binding residues [nucleotide binding] 1279365015281 putative dimer interface [polypeptide binding]; other site 1279365015282 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1279365015283 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1279365015284 catalytic site [active] 1279365015285 active site 1279365015286 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1279365015287 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1279365015288 active site 1279365015289 Transglycosylase; Region: Transgly; pfam00912 1279365015290 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1279365015291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1279365015292 YwhD family; Region: YwhD; pfam08741 1279365015293 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1279365015294 Peptidase family M50; Region: Peptidase_M50; pfam02163 1279365015295 active site 1279365015296 putative substrate binding region [chemical binding]; other site 1279365015297 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1279365015298 active site 1 [active] 1279365015299 dimer interface [polypeptide binding]; other site 1279365015300 hexamer interface [polypeptide binding]; other site 1279365015301 active site 2 [active] 1279365015302 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1279365015303 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1279365015304 Zn2+ binding site [ion binding]; other site 1279365015305 Mg2+ binding site [ion binding]; other site 1279365015306 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1279365015307 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1279365015308 intersubunit interface [polypeptide binding]; other site 1279365015309 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1279365015310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1279365015311 Walker A/P-loop; other site 1279365015312 ATP binding site [chemical binding]; other site 1279365015313 Q-loop/lid; other site 1279365015314 ABC transporter signature motif; other site 1279365015315 Walker B; other site 1279365015316 D-loop; other site 1279365015317 H-loop/switch region; other site 1279365015318 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1279365015319 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365015320 ABC-ATPase subunit interface; other site 1279365015321 dimer interface [polypeptide binding]; other site 1279365015322 putative PBP binding regions; other site 1279365015323 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1279365015324 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1279365015325 ABC-ATPase subunit interface; other site 1279365015326 dimer interface [polypeptide binding]; other site 1279365015327 putative PBP binding regions; other site 1279365015328 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1279365015329 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1279365015330 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1279365015331 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1279365015332 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1279365015333 putative heme peroxidase; Provisional; Region: PRK12276 1279365015334 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1279365015335 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1279365015336 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1279365015337 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1279365015338 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1279365015339 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1279365015340 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1279365015341 Ion channel; Region: Ion_trans_2; pfam07885 1279365015342 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1279365015343 TrkA-N domain; Region: TrkA_N; pfam02254 1279365015344 TrkA-C domain; Region: TrkA_C; pfam02080 1279365015345 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1279365015346 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1279365015347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365015348 motif II; other site 1279365015349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365015350 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1279365015351 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1279365015352 ligand binding site [chemical binding]; other site 1279365015353 active site 1279365015354 UGI interface [polypeptide binding]; other site 1279365015355 catalytic site [active] 1279365015356 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1279365015357 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1279365015358 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1279365015359 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1279365015360 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1279365015361 Walker A/P-loop; other site 1279365015362 ATP binding site [chemical binding]; other site 1279365015363 Q-loop/lid; other site 1279365015364 ABC transporter signature motif; other site 1279365015365 Walker B; other site 1279365015366 D-loop; other site 1279365015367 H-loop/switch region; other site 1279365015368 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1279365015369 active site 1279365015370 catalytic triad [active] 1279365015371 oxyanion hole [active] 1279365015372 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1279365015373 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1279365015374 DNA binding site [nucleotide binding] 1279365015375 domain linker motif; other site 1279365015376 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1279365015377 putative dimerization interface [polypeptide binding]; other site 1279365015378 putative ligand binding site [chemical binding]; other site 1279365015379 Predicted membrane protein [Function unknown]; Region: COG2364 1279365015380 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1279365015381 homoserine dehydrogenase; Provisional; Region: PRK06349 1279365015382 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1279365015383 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1279365015384 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1279365015385 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1279365015386 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1279365015387 proposed active site lysine [active] 1279365015388 conserved cys residue [active] 1279365015389 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 1279365015390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1279365015391 homodimer interface [polypeptide binding]; other site 1279365015392 substrate-cofactor binding pocket; other site 1279365015393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1279365015394 catalytic residue [active] 1279365015395 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1279365015396 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1279365015397 Cl- selectivity filter; other site 1279365015398 Cl- binding residues [ion binding]; other site 1279365015399 pore gating glutamate residue; other site 1279365015400 dimer interface [polypeptide binding]; other site 1279365015401 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1279365015402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1279365015403 active site 1279365015404 motif I; other site 1279365015405 motif II; other site 1279365015406 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1279365015407 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1279365015408 ligand binding site [chemical binding]; other site 1279365015409 flexible hinge region; other site 1279365015410 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1279365015411 azoreductase; Provisional; Region: PRK13556 1279365015412 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365015413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365015414 active site 1279365015415 phosphorylation site [posttranslational modification] 1279365015416 intermolecular recognition site; other site 1279365015417 dimerization interface [polypeptide binding]; other site 1279365015418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1279365015419 DNA binding residues [nucleotide binding] 1279365015420 dimerization interface [polypeptide binding]; other site 1279365015421 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1279365015422 GAF domain; Region: GAF; pfam01590 1279365015423 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1279365015424 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1279365015425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1279365015426 Histidine kinase; Region: HisKA_3; pfam07730 1279365015427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365015428 ATP binding site [chemical binding]; other site 1279365015429 Mg2+ binding site [ion binding]; other site 1279365015430 G-X-G motif; other site 1279365015431 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1279365015432 dimer interface [polypeptide binding]; other site 1279365015433 substrate binding site [chemical binding]; other site 1279365015434 ATP binding site [chemical binding]; other site 1279365015435 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1279365015436 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1279365015437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1279365015438 metal binding site [ion binding]; metal-binding site 1279365015439 active site 1279365015440 I-site; other site 1279365015441 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1279365015442 carbon starvation protein A; Provisional; Region: PRK15015 1279365015443 Carbon starvation protein CstA; Region: CstA; pfam02554 1279365015444 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1279365015445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365015446 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1279365015447 active site 1279365015448 phosphorylation site [posttranslational modification] 1279365015449 intermolecular recognition site; other site 1279365015450 dimerization interface [polypeptide binding]; other site 1279365015451 LytTr DNA-binding domain; Region: LytTR; pfam04397 1279365015452 benzoate transport; Region: 2A0115; TIGR00895 1279365015453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365015454 putative substrate translocation pore; other site 1279365015455 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1279365015456 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1279365015457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1279365015458 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1279365015459 Predicted membrane protein [Function unknown]; Region: COG2860 1279365015460 UPF0126 domain; Region: UPF0126; pfam03458 1279365015461 UPF0126 domain; Region: UPF0126; pfam03458 1279365015462 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1279365015463 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1279365015464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365015465 dimer interface [polypeptide binding]; other site 1279365015466 putative CheW interface [polypeptide binding]; other site 1279365015467 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1279365015468 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1279365015469 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365015470 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1279365015471 Ligand binding site; other site 1279365015472 Putative Catalytic site; other site 1279365015473 DXD motif; other site 1279365015474 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1279365015475 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1279365015476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1279365015477 active site 1279365015478 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1279365015479 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1279365015480 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1279365015481 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1279365015482 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1279365015483 DXD motif; other site 1279365015484 Putative Catalytic site; other site 1279365015485 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1279365015486 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365015487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365015488 ABC transporter; Region: ABC_tran_2; pfam12848 1279365015489 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1279365015490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1279365015491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1279365015492 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1279365015493 Protein export membrane protein; Region: SecD_SecF; cl14618 1279365015494 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1279365015495 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1279365015496 SelR domain; Region: SelR; pfam01641 1279365015497 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1279365015498 antiholin-like protein LrgB; Provisional; Region: PRK04288 1279365015499 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1279365015500 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1279365015501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365015502 active site 1279365015503 phosphorylation site [posttranslational modification] 1279365015504 intermolecular recognition site; other site 1279365015505 dimerization interface [polypeptide binding]; other site 1279365015506 LytTr DNA-binding domain; Region: LytTR; pfam04397 1279365015507 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1279365015508 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1279365015509 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1279365015510 Histidine kinase; Region: His_kinase; pfam06580 1279365015511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365015512 ATP binding site [chemical binding]; other site 1279365015513 Mg2+ binding site [ion binding]; other site 1279365015514 G-X-G motif; other site 1279365015515 benzoate transport; Region: 2A0115; TIGR00895 1279365015516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1279365015517 putative substrate translocation pore; other site 1279365015518 BCCT family transporter; Region: BCCT; pfam02028 1279365015519 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1279365015520 active site 1279365015521 dimer interface [polypeptide binding]; other site 1279365015522 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1279365015523 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1279365015524 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1279365015525 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1279365015526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1279365015527 NAD(P) binding site [chemical binding]; other site 1279365015528 active site 1279365015529 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1279365015530 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1279365015531 UDP-glucose 4-epimerase; Region: PLN02240 1279365015532 NAD binding site [chemical binding]; other site 1279365015533 homodimer interface [polypeptide binding]; other site 1279365015534 active site 1279365015535 substrate binding site [chemical binding]; other site 1279365015536 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1279365015537 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1279365015538 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1279365015539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1279365015540 putative Mg++ binding site [ion binding]; other site 1279365015541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1279365015542 nucleotide binding region [chemical binding]; other site 1279365015543 ATP-binding site [chemical binding]; other site 1279365015544 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1279365015545 RNA binding site [nucleotide binding]; other site 1279365015546 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365015547 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365015548 putative active site [active] 1279365015549 putative NTP binding site [chemical binding]; other site 1279365015550 putative nucleic acid binding site [nucleotide binding]; other site 1279365015551 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365015552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015553 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1279365015554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1279365015555 ATP binding site [chemical binding]; other site 1279365015556 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1279365015557 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1279365015558 active site 1279365015559 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365015560 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1279365015561 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1279365015562 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1279365015563 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1279365015564 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1279365015565 GAF domain; Region: GAF_2; pfam13185 1279365015566 GAF domain; Region: GAF_3; pfam13492 1279365015567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365015568 PAS domain; Region: PAS_9; pfam13426 1279365015569 putative active site [active] 1279365015570 heme pocket [chemical binding]; other site 1279365015571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365015572 dimer interface [polypeptide binding]; other site 1279365015573 phosphorylation site [posttranslational modification] 1279365015574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365015575 ATP binding site [chemical binding]; other site 1279365015576 Mg2+ binding site [ion binding]; other site 1279365015577 G-X-G motif; other site 1279365015578 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1279365015579 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1279365015580 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1279365015581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1279365015582 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1279365015583 protein binding site [polypeptide binding]; other site 1279365015584 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1279365015585 YycH protein; Region: YycI; pfam09648 1279365015586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1279365015587 YycH protein; Region: YycH; pfam07435 1279365015588 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1279365015589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1279365015590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1279365015591 dimerization interface [polypeptide binding]; other site 1279365015592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1279365015593 putative active site [active] 1279365015594 heme pocket [chemical binding]; other site 1279365015595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1279365015596 dimer interface [polypeptide binding]; other site 1279365015597 phosphorylation site [posttranslational modification] 1279365015598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365015599 ATP binding site [chemical binding]; other site 1279365015600 Mg2+ binding site [ion binding]; other site 1279365015601 G-X-G motif; other site 1279365015602 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1279365015603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1279365015604 active site 1279365015605 phosphorylation site [posttranslational modification] 1279365015606 intermolecular recognition site; other site 1279365015607 dimerization interface [polypeptide binding]; other site 1279365015608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1279365015609 DNA binding site [nucleotide binding] 1279365015610 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1279365015611 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1279365015612 GDP-binding site [chemical binding]; other site 1279365015613 ACT binding site; other site 1279365015614 IMP binding site; other site 1279365015615 replicative DNA helicase; Provisional; Region: PRK05748 1279365015616 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1279365015617 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1279365015618 Walker A motif; other site 1279365015619 ATP binding site [chemical binding]; other site 1279365015620 Walker B motif; other site 1279365015621 DNA binding loops [nucleotide binding] 1279365015622 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1279365015623 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1279365015624 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1279365015625 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1279365015626 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1279365015627 DHH family; Region: DHH; pfam01368 1279365015628 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1279365015629 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1279365015630 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1279365015631 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1279365015632 dimer interface [polypeptide binding]; other site 1279365015633 ssDNA binding site [nucleotide binding]; other site 1279365015634 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1279365015635 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1279365015636 GTP-binding protein YchF; Reviewed; Region: PRK09601 1279365015637 YchF GTPase; Region: YchF; cd01900 1279365015638 G1 box; other site 1279365015639 GTP/Mg2+ binding site [chemical binding]; other site 1279365015640 Switch I region; other site 1279365015641 G2 box; other site 1279365015642 Switch II region; other site 1279365015643 G3 box; other site 1279365015644 G4 box; other site 1279365015645 G5 box; other site 1279365015646 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1279365015647 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1279365015648 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1279365015649 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1279365015650 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1279365015651 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1279365015652 ParB-like nuclease domain; Region: ParB; smart00470 1279365015653 KorB domain; Region: KorB; pfam08535 1279365015654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1279365015655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1279365015656 P-loop; other site 1279365015657 Magnesium ion binding site [ion binding]; other site 1279365015658 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1279365015659 Magnesium ion binding site [ion binding]; other site 1279365015660 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1279365015661 ParB-like nuclease domain; Region: ParBc; pfam02195 1279365015662 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1279365015663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1279365015664 S-adenosylmethionine binding site [chemical binding]; other site 1279365015665 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1279365015666 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1279365015667 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1279365015668 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1279365015669 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1279365015670 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1279365015671 G1 box; other site 1279365015672 GTP/Mg2+ binding site [chemical binding]; other site 1279365015673 Switch I region; other site 1279365015674 G2 box; other site 1279365015675 Switch II region; other site 1279365015676 G3 box; other site 1279365015677 G4 box; other site 1279365015678 G5 box; other site 1279365015679 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1279365015680 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1279365015681 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1279365015682 G-X-X-G motif; other site 1279365015683 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1279365015684 RxxxH motif; other site 1279365015685 OxaA-like protein precursor; Validated; Region: PRK02944 1279365015686 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1279365015687 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1279365015688 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1279365015689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365015690 Integrase core domain; Region: rve; pfam00665 1279365015691 transposase/IS protein; Provisional; Region: PRK09183 1279365015692 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015693 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015694 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1279365015695 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1279365015696 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1279365015697 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1279365015698 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365015699 active site 1279365015700 catalytic residues [active] 1279365015701 DNA binding site [nucleotide binding] 1279365015702 Int/Topo IB signature motif; other site 1279365015703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365015704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1279365015705 Walker A motif; other site 1279365015706 ATP binding site [chemical binding]; other site 1279365015707 Walker B motif; other site 1279365015708 arginine finger; other site 1279365015709 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1279365015710 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1279365015711 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1279365015712 NlpC/P60 family; Region: NLPC_P60; pfam00877 1279365015713 Domain of unknown function DUF87; Region: DUF87; pfam01935 1279365015714 AAA-like domain; Region: AAA_10; pfam12846 1279365015715 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365015716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365015717 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365015718 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1279365015719 Mg binding site [ion binding]; other site 1279365015720 nucleotide binding site [chemical binding]; other site 1279365015721 putative protofilament interface [polypeptide binding]; other site 1279365015722 MobA/MobL family; Region: MobA_MobL; pfam03389 1279365015723 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365015724 ATP binding site [chemical binding]; other site 1279365015725 Walker B motif; other site 1279365015726 DNA topoisomerase III; Provisional; Region: PRK07726 1279365015727 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1279365015728 active site 1279365015729 putative interdomain interaction site [polypeptide binding]; other site 1279365015730 putative metal-binding site [ion binding]; other site 1279365015731 putative nucleotide binding site [chemical binding]; other site 1279365015732 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1279365015733 domain I; other site 1279365015734 DNA binding groove [nucleotide binding] 1279365015735 phosphate binding site [ion binding]; other site 1279365015736 domain II; other site 1279365015737 domain III; other site 1279365015738 nucleotide binding site [chemical binding]; other site 1279365015739 catalytic site [active] 1279365015740 domain IV; other site 1279365015741 AAA domain; Region: AAA_31; pfam13614 1279365015742 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1279365015743 AAA domain; Region: AAA_31; pfam13614 1279365015744 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1279365015745 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365015746 Walker A motif; other site 1279365015747 ATP binding site [chemical binding]; other site 1279365015748 Walker B motif; other site 1279365015749 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365015750 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365015751 CARDB; Region: CARDB; pfam07705 1279365015752 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1279365015753 putative active site [active] 1279365015754 catalytic site [active] 1279365015755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1279365015756 binding surface 1279365015757 TPR motif; other site 1279365015758 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1279365015759 putative active site [active] 1279365015760 chaperone protein DnaJ; Provisional; Region: PRK14279 1279365015761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1279365015762 dimerization interface [polypeptide binding]; other site 1279365015763 putative DNA binding site [nucleotide binding]; other site 1279365015764 putative Zn2+ binding site [ion binding]; other site 1279365015765 Helix-turn-helix domain; Region: HTH_17; pfam12728 1279365015766 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1279365015767 S-layer homology domain; Region: SLH; pfam00395 1279365015768 S-layer homology domain; Region: SLH; pfam00395 1279365015769 S-layer homology domain; Region: SLH; pfam00395 1279365015770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365015771 non-specific DNA binding site [nucleotide binding]; other site 1279365015772 salt bridge; other site 1279365015773 sequence-specific DNA binding site [nucleotide binding]; other site 1279365015774 MAEBL; Provisional; Region: PTZ00121 1279365015775 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365015776 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365015777 putative active site [active] 1279365015778 putative NTP binding site [chemical binding]; other site 1279365015779 putative nucleic acid binding site [nucleotide binding]; other site 1279365015780 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1279365015781 active site 1279365015782 AAA-like domain; Region: AAA_10; pfam12846 1279365015783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1279365015784 putative Mg++ binding site [ion binding]; other site 1279365015785 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 1279365015786 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365015787 Type II/IV secretion system protein; Region: T2SE; pfam00437 1279365015788 Walker A motif; other site 1279365015789 ATP binding site [chemical binding]; other site 1279365015790 Walker B motif; other site 1279365015791 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1279365015792 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1279365015793 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1279365015794 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1279365015795 P-loop; other site 1279365015796 Magnesium ion binding site [ion binding]; other site 1279365015797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1279365015798 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1279365015799 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1279365015800 peptide binding site [polypeptide binding]; other site 1279365015801 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1279365015802 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1279365015803 DNA binding residues [nucleotide binding] 1279365015804 YolD-like protein; Region: YolD; pfam08863 1279365015805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1279365015806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1279365015807 Transposase domain (DUF772); Region: DUF772; pfam05598 1279365015808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015809 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1279365015810 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1279365015811 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1279365015812 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1279365015813 catalytic residues [active] 1279365015814 catalytic nucleophile [active] 1279365015815 Presynaptic Site I dimer interface [polypeptide binding]; other site 1279365015816 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1279365015817 Synaptic Flat tetramer interface [polypeptide binding]; other site 1279365015818 Synaptic Site I dimer interface [polypeptide binding]; other site 1279365015819 DNA binding site [nucleotide binding] 1279365015820 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365015821 active site 1279365015822 catalytic residues [active] 1279365015823 DNA binding site [nucleotide binding] 1279365015824 Int/Topo IB signature motif; other site 1279365015825 CAAX protease self-immunity; Region: Abi; pfam02517 1279365015826 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1279365015827 DNA topoisomerase III; Provisional; Region: PRK07726 1279365015828 active site 1279365015829 putative interdomain interaction site [polypeptide binding]; other site 1279365015830 putative metal-binding site [ion binding]; other site 1279365015831 putative nucleotide binding site [chemical binding]; other site 1279365015832 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1279365015833 domain I; other site 1279365015834 DNA binding groove [nucleotide binding] 1279365015835 phosphate binding site [ion binding]; other site 1279365015836 domain II; other site 1279365015837 domain III; other site 1279365015838 nucleotide binding site [chemical binding]; other site 1279365015839 catalytic site [active] 1279365015840 domain IV; other site 1279365015841 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1279365015842 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1279365015843 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 1279365015844 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1279365015845 Toprim-like; Region: Toprim_2; pfam13155 1279365015846 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1279365015847 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1279365015848 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1279365015849 Replication protein; Region: Rep_1; cl02412 1279365015850 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 1279365015851 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1279365015852 AAA domain; Region: AAA_30; pfam13604 1279365015853 Family description; Region: UvrD_C_2; pfam13538 1279365015854 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1279365015855 Replication protein; Region: Rep_1; cl02412 1279365015856 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1279365015857 transposase/IS protein; Provisional; Region: PRK09183 1279365015858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365015859 Walker A motif; other site 1279365015860 ATP binding site [chemical binding]; other site 1279365015861 Walker B motif; other site 1279365015862 arginine finger; other site 1279365015863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365015864 Integrase core domain; Region: rve; pfam00665 1279365015865 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1279365015866 delta endotoxin; Region: Endotoxin_M; pfam00555 1279365015867 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 1279365015868 putative metal binding site [ion binding]; other site 1279365015869 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1279365015870 amidase catalytic site [active] 1279365015871 Zn binding residues [ion binding]; other site 1279365015872 substrate binding site [chemical binding]; other site 1279365015873 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1279365015874 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1279365015875 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365015877 Integrase core domain; Region: rve; pfam00665 1279365015878 transposase/IS protein; Provisional; Region: PRK09183 1279365015879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365015880 Walker A motif; other site 1279365015881 ATP binding site [chemical binding]; other site 1279365015882 Walker B motif; other site 1279365015883 arginine finger; other site 1279365015884 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1279365015885 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1279365015886 catalytic residues [active] 1279365015887 catalytic nucleophile [active] 1279365015888 Presynaptic Site I dimer interface [polypeptide binding]; other site 1279365015889 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1279365015890 Synaptic Flat tetramer interface [polypeptide binding]; other site 1279365015891 Synaptic Site I dimer interface [polypeptide binding]; other site 1279365015892 DNA binding site [nucleotide binding] 1279365015893 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1279365015894 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1279365015895 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015896 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015897 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1279365015898 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1279365015899 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1279365015900 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1279365015901 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365015902 active site 1279365015903 catalytic residues [active] 1279365015904 DNA binding site [nucleotide binding] 1279365015905 Int/Topo IB signature motif; other site 1279365015906 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015907 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1279365015909 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1279365015910 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1279365015911 putative active site [active] 1279365015912 putative NTP binding site [chemical binding]; other site 1279365015913 putative nucleic acid binding site [nucleotide binding]; other site 1279365015914 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1279365015915 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365015916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365015917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365015918 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365015919 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1279365015920 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1279365015921 active site 1279365015922 catalytic residues [active] 1279365015923 DNA binding site [nucleotide binding] 1279365015924 Int/Topo IB signature motif; other site 1279365015925 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1279365015926 Mg binding site [ion binding]; other site 1279365015927 nucleotide binding site [chemical binding]; other site 1279365015928 putative protofilament interface [polypeptide binding]; other site 1279365015929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1279365015930 Integrase core domain; Region: rve; pfam00665 1279365015931 transposase/IS protein; Provisional; Region: PRK09183 1279365015932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1279365015933 Walker A motif; other site 1279365015934 ATP binding site [chemical binding]; other site 1279365015935 Walker B motif; other site 1279365015936 arginine finger; other site 1279365015937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1279365015938 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1279365015939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1279365015940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1279365015941 ATP binding site [chemical binding]; other site 1279365015942 Mg2+ binding site [ion binding]; other site 1279365015943 G-X-G motif; other site 1279365015944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1279365015945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1279365015946 active site 1279365015947 phosphorylation site [posttranslational modification] 1279365015948 intermolecular recognition site; other site 1279365015949 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1279365015950 DNA binding residues [nucleotide binding] 1279365015951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365015952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365015953 non-specific DNA binding site [nucleotide binding]; other site 1279365015954 salt bridge; other site 1279365015955 sequence-specific DNA binding site [nucleotide binding]; other site 1279365015956 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1279365015957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365015958 sequence-specific DNA binding site [nucleotide binding]; other site 1279365015959 salt bridge; other site 1279365015960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1279365015961 non-specific DNA binding site [nucleotide binding]; other site 1279365015962 salt bridge; other site 1279365015963 sequence-specific DNA binding site [nucleotide binding]; other site 1279365015964 S-layer homology domain; Region: SLH; pfam00395 1279365015965 S-layer homology domain; Region: SLH; pfam00395 1279365015966 S-layer homology domain; Region: SLH; pfam00395 1279365015967 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1279365015968 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1279365015969 AAA domain; Region: AAA_31; pfam13614 1279365015970 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1279365015971 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1279365015972 Walker A motif; other site 1279365015973 ATP binding site [chemical binding]; other site 1279365015974 Walker B motif; other site 1279365015975 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1279365015976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365015977 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365015978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365015979 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 1279365015980 AAA-like domain; Region: AAA_10; pfam12846 1279365015981 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1279365015982 Replication-relaxation; Region: Replic_Relax; pfam13814 1279365015983 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1279365015984 TcpE family; Region: TcpE; pfam12648 1279365015985 AAA-like domain; Region: AAA_10; pfam12846 1279365015986 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1279365015987 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1279365015988 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1279365015989 Peptidase family M23; Region: Peptidase_M23; pfam01551 1279365015990 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1279365015991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1279365015992 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1279365015993 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1279365015994 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1279365015995 Interdomain contacts; other site 1279365015996 Cytokine receptor motif; other site 1279365015997 Replication initiation factor; Region: Rep_trans; pfam02486